Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4e4m_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASP 6.A N ASP 4.A OD1 no hydrogen 3.370 N/A THR 8.A N ASP 6.A OD1 no hydrogen 3.405 N/A THR 8.A OG1 ASP 6.A OD1 no hydrogen 2.582 N/A GLN 9.A N ASP 6.A O no hydrogen 3.140 N/A GLN 9.A NE2 ASP 6.A OD2 no hydrogen 2.769 N/A PHE 10.A N VAL 82.A O no hydrogen 2.814 N/A GLU 11.A N TYR 34.A OH no hydrogen 2.847 N/A ARG 13.A NH2 GLU 11.A OE2 no hydrogen 3.546 N/A HIS 14.A N GLU 11.A O no hydrogen 2.882 N/A LEU 15.A N GLU 12.A O no hydrogen 3.157 N/A LYS 16.A N ARG 33.A O no hydrogen 2.929 N/A LEU 18.A N MET 31.A O no hydrogen 2.894 N/A GLN 19.A N MET 31.A O no hydrogen 3.189 N/A GLN 19.A NE2 GLN 20.A O no hydrogen 3.371 N/A GLN 20.A NE2 SER 28.A OG no hydrogen 2.579 N/A LEU 21.A N VAL 29.A O no hydrogen 2.967 N/A GLY 22.A N VAL 29.A O no hydrogen 3.119 N/A GLY 24.A N GLY 27.A O no hydrogen 3.214 N/A ASN 25.A N ASP 160.A OD2 no hydrogen 2.773 N/A ASN 25.A ND2 ASP 142.A OD2 no hydrogen 2.794 N/A ASN 25.A ND2 ASP 160.A OD1 no hydrogen 2.826 N/A GLY 27.A N GLY 24.A O no hydrogen 2.967 N/A SER 28.A N LYS 49.A O no hydrogen 2.933 N/A VAL 29.A N GLY 22.A O no hydrogen 2.791 N/A GLU 30.A N VAL 47.A O no hydrogen 2.912 N/A MET 31.A N GLN 19.A O no hydrogen 2.684 N/A CYS 32.A N VAL 45.A O no hydrogen 2.833 N/A ARG 33.A N LYS 16.A O no hydrogen 2.897 N/A ARG 33.A NE GLY 42.A O no hydrogen 3.302 N/A TYR 34.A N GLU 43.A O no hydrogen 2.921 N/A ASP 35.A N HIS 14.A O no hydrogen 3.154 N/A GLN 38.A N ASP 35.A O no hydrogen 3.203 N/A GLN 38.A NE2 ASP 35.A O no hydrogen 3.316 N/A ASN 40.A N ASP 35.A OD2 no hydrogen 2.804 N/A THR 41.A N ASP 39.A OD1 no hydrogen 3.232 N/A THR 41.A OG1 ASP 39.A OD1 no hydrogen 2.699 N/A THR 41.A OG1 ASP 39.A OD2 no hydrogen 2.713 N/A VAL 45.A N CYS 32.A O no hydrogen 2.753 N/A ALA 46.A N MET 95.A O no hydrogen 3.064 N/A VAL 47.A N GLU 30.A O no hydrogen 2.862 N/A LYS 48.A N LEU 93.A O no hydrogen 2.914 N/A LYS 48.A NZ ASN 25.A O no hydrogen 3.165 N/A LYS 48.A NZ GLU 64.A OE1 no hydrogen 2.778 N/A LYS 48.A NZ GLU 64.A OE2 no hydrogen 2.989 N/A LYS 49.A N SER 28.A O no hydrogen 2.911 N/A LYS 49.A NZ GLU 30.A OE2 no hydrogen 2.950 N/A GLN 51.A N PHE 26.A O no hydrogen 3.382 N/A SER 53.A OG THR 54.A O no hydrogen 3.493 N/A HIS 57.A N THR 54.A OG1 no hydrogen 3.181 N/A LEU 58.A N THR 54.A O no hydrogen 3.051 N/A ARG 59.A N GLU 55.A O no hydrogen 3.218 N/A ARG 59.A NE GLU 62.A OE2 no hydrogen 3.457 N/A ASP 60.A N GLU 56.A O no hydrogen 3.018 N/A PHE 61.A N HIS 57.A O no hydrogen 2.804 N/A GLU 62.A N LEU 58.A O no hydrogen 2.830 N/A ARG 63.A N ARG 59.A O no hydrogen 3.139 N/A GLU 64.A N ASP 60.A O no hydrogen 2.971 N/A ILE 65.A N PHE 61.A O no hydrogen 2.924 N/A GLU 66.A N GLU 62.A O no hydrogen 3.167 N/A ILE 67.A N ARG 63.A O no hydrogen 2.851 N/A LEU 68.A N GLU 64.A O no hydrogen 2.796 N/A LYS 69.A N ILE 65.A O no hydrogen 2.933 N/A SER 70.A N GLU 66.A O no hydrogen 3.056 N/A SER 70.A OG GLU 66.A O no hydrogen 3.345 N/A SER 70.A OG ILE 67.A O no hydrogen 2.442 N/A SER 70.A OG TYR 138.A OH no hydrogen 2.612 N/A LEU 71.A N LEU 68.A O no hydrogen 3.184 N/A GLN 72.A N TYR 132.A OH no hydrogen 2.899 N/A ASN 75.A N HIS 73.A ND1 no hydrogen 3.029 N/A ILE 76.A N HIS 73.A O no hydrogen 3.212 N/A VAL 77.A N ILE 158.A O no hydrogen 3.139 N/A LYS 78.A N GLU 96.A OE1 no hydrogen 2.920 N/A LYS 80.A N ILE 94.A O no hydrogen 2.888 N/A GLY 81.A N ILE 94.A O no hydrogen 3.178 N/A VAL 82.A N THR 8.A O no hydrogen 2.696 N/A CYS 83.A N LYS 92.A O no hydrogen 2.872 N/A CYS 83.A SG PHE 10.A O no hydrogen 3.398 N/A ALA 86.A N GLU 12.A OE2 no hydrogen 2.723 N/A GLY 87.A N GLU 12.A OE1 no hydrogen 3.177 N/A ARG 88.A N TYR 84.A O no hydrogen 3.085 N/A ARG 89.A N SER 85.A O no hydrogen 2.964 N/A ARG 89.A N ALA 86.A O no hydrogen 3.216 N/A ARG 89.A NE ALA 86.A O no hydrogen 3.112 N/A ARG 89.A NH2 ALA 86.A O no hydrogen 3.091 N/A LYS 92.A N CYS 83.A O no hydrogen 2.933 N/A LEU 93.A N LYS 48.A O no hydrogen 3.067 N/A ILE 94.A N GLY 81.A O no hydrogen 2.849 N/A MET 95.A N ALA 46.A O no hydrogen 2.754 N/A GLU 96.A N LYS 78.A O no hydrogen 2.947 N/A GLY 101.A N LEU 98.A O no hydrogen 3.099 N/A SER 102.A OG ASP 105.A OD1 no hydrogen 3.007 N/A LEU 103.A N ILE 148.A O no hydrogen 2.879 N/A ARG 104.A N THR 145.A O no hydrogen 3.264 N/A ASP 105.A N SER 102.A OG no hydrogen 3.205 N/A TYR 106.A N SER 102.A O no hydrogen 2.920 N/A LEU 107.A N LEU 103.A O no hydrogen 2.750 N/A GLN 108.A N ARG 104.A O no hydrogen 3.301 N/A LYS 109.A N ASP 105.A O no hydrogen 2.922 N/A HIS 110.A N TYR 106.A O no hydrogen 2.928 N/A ARG 113.A N HIS 110.A O no hydrogen 3.164 N/A ARG 113.A NH2 TYR 106.A OH no hydrogen 3.266 N/A ILE 114.A N LYS 111.A O no hydrogen 3.066 N/A LYS 118.A N ASP 115.A OD1 no hydrogen 3.156 N/A LYS 118.A NZ GLU 153.A O no hydrogen 2.763 N/A LYS 118.A NZ ASN 154.A OD1 no hydrogen 2.314 N/A LEU 119.A N ASP 115.A O no hydrogen 3.045 N/A LEU 120.A N HIS 116.A O no hydrogen 2.959 N/A GLN 121.A N ILE 117.A O no hydrogen 2.882 N/A TYR 122.A N LYS 118.A O no hydrogen 2.910 N/A TYR 122.A OH GLU 153.A O no hydrogen 2.650 N/A THR 123.A N LEU 119.A O no hydrogen 2.918 N/A THR 123.A OG1 LEU 119.A O no hydrogen 2.819 N/A SER 124.A N LEU 120.A O no hydrogen 2.848 N/A SER 124.A OG ASP 288.A OD1 no hydrogen 2.613 N/A SER 124.A OG ASP 288.A OD2 no hydrogen 3.415 N/A GLN 125.A N GLN 121.A O no hydrogen 3.071 N/A GLN 125.A NE2 ASN 154.A O no hydrogen 2.889 N/A ILE 126.A N TYR 122.A O no hydrogen 2.930 N/A CYS 127.A N THR 123.A O no hydrogen 3.097 N/A CYS 127.A SG THR 123.A O no hydrogen 3.531 N/A LYS 128.A N SER 124.A O no hydrogen 3.048 N/A LYS 128.A NZ SER 124.A OG no hydrogen 3.059 N/A LYS 128.A NZ ASP 288.A OD2 no hydrogen 2.590 N/A GLY 129.A N GLN 125.A O no hydrogen 2.985 N/A MET 130.A N ILE 126.A O no hydrogen 2.942 N/A GLU 131.A N CYS 127.A O no hydrogen 2.678 N/A TYR 132.A N LYS 128.A O no hydrogen 3.003 N/A LEU 133.A N GLY 129.A O no hydrogen 3.016 N/A GLY 134.A N MET 130.A O no hydrogen 3.070 N/A THR 135.A N TYR 132.A O no hydrogen 3.176 N/A THR 135.A OG1 TYR 132.A O no hydrogen 2.605 N/A LYS 136.A N LEU 133.A O no hydrogen 3.171 N/A ARG 137.A N GLY 134.A O no hydrogen 3.138 N/A ARG 137.A NH1 GLU 172.A OE1 no hydrogen 3.506 N/A ARG 137.A NH2 GLU 172.A OE1 no hydrogen 3.228 N/A TYR 138.A N LEU 133.A O no hydrogen 3.113 N/A TYR 138.A OH SER 70.A OG no hydrogen 2.612 N/A ILE 139.A N LYS 165.A O no hydrogen 2.676 N/A HIS 140.A N ASP 200.A OD2 no hydrogen 2.846 N/A HIS 140.A NE2 GLY 159.A O no hydrogen 2.765 N/A ARG 141.A N ASP 200.A OD1 no hydrogen 3.063 N/A ARG 141.A NE LEU 163.A O no hydrogen 2.893 N/A ARG 141.A NH1 GLU 176.A OE1 no hydrogen 3.528 N/A ARG 141.A NH2 GLU 176.A OE1 no hydrogen 2.991 N/A ASP 142.A N HIS 140.A ND1 no hydrogen 3.228 N/A THR 145.A N GLU 210.A OE2 no hydrogen 3.063 N/A THR 145.A OG1 GLU 210.A OE1 no hydrogen 2.560 N/A ARG 146.A NH2 ASP 142.A OD1 no hydrogen 3.348 N/A ASN 147.A N ALA 144.A O no hydrogen 2.951 N/A ASN 147.A ND2 ASP 142.A O no hydrogen 2.756 N/A ILE 148.A N THR 145.A O no hydrogen 3.339 N/A LEU 149.A N LYS 157.A O no hydrogen 2.552 N/A VAL 150.A N GLY 101.A O no hydrogen 2.927 N/A GLU 151.A N ARG 155.A O no hydrogen 2.916 N/A ASN 152.A N ARG 155.A O no hydrogen 3.482 N/A ASN 154.A N ASN 152.A OD1 no hydrogen 2.874 N/A ARG 155.A N ASN 152.A O no hydrogen 3.330 N/A VAL 156.A N GLN 125.A OE1 no hydrogen 2.885 N/A LYS 157.A N LEU 149.A O no hydrogen 2.618 N/A LYS 157.A NZ GLU 96.A OE1 no hydrogen 2.760 N/A LYS 157.A NZ GLU 96.A OE2 no hydrogen 3.553 N/A ILE 158.A N ASN 75.A O no hydrogen 2.787 N/A GLY 159.A N ASN 147.A O no hydrogen 2.807 N/A GLY 162.A N ASP 160.A OD1 no hydrogen 2.960 N/A THR 164.A N PHE 161.A O no hydrogen 3.083 N/A THR 164.A OG1 HIS 140.A O no hydrogen 3.247 N/A THR 164.A OG1 PHE 161.A O no hydrogen 3.229 N/A LYS 165.A N ILE 139.A O no hydrogen 2.905 N/A LEU 167.A N ARG 137.A O no hydrogen 2.986 N/A GLN 169.A N LEU 167.A O no hydrogen 2.677 N/A ASP 170.A N PRO 168.A O no hydrogen 2.996 N/A VAL 174.A N SER 193.A O no hydrogen 3.116 N/A TRP 184.A N PRO 181.A O no hydrogen 3.164 N/A TRP 184.A NE1 GLU 210.A OE2 no hydrogen 2.976 N/A TYR 185.A N ILE 182.A O no hydrogen 3.176 N/A GLU 188.A N GLU 188.A OE1 no hydrogen 2.689 N/A SER 189.A N ALA 186.A O no hydrogen 3.028 N/A SER 189.A OG LYS 194.A O no hydrogen 2.729 N/A LEU 190.A N ALA 186.A O no hydrogen 3.083 N/A THR 191.A N PRO 187.A O no hydrogen 2.854 N/A THR 191.A OG1 PRO 187.A O no hydrogen 2.984 N/A GLU 192.A N GLU 188.A O no hydrogen 2.934 N/A SER 193.A N SER 189.A O no hydrogen 3.188 N/A LYS 194.A N GLU 188.A O no hydrogen 3.212 N/A SER 196.A N SER 199.A OG no hydrogen 2.930 N/A SER 199.A N SER 196.A OG no hydrogen 3.251 N/A SER 199.A OG SER 196.A O no hydrogen 2.954 N/A ASP 200.A N SER 196.A O no hydrogen 3.214 N/A VAL 201.A N VAL 197.A O no hydrogen 2.976 N/A TRP 202.A N ALA 198.A O no hydrogen 2.977 N/A SER 203.A N SER 199.A O no hydrogen 3.030 N/A SER 203.A OG TRP 184.A O no hydrogen 2.764 N/A SER 203.A OG SER 199.A O no hydrogen 2.966 N/A PHE 204.A N ASP 200.A O no hydrogen 2.758 N/A GLY 205.A N VAL 201.A O no hydrogen 3.010 N/A VAL 206.A N TRP 202.A O no hydrogen 3.338 N/A VAL 207.A N SER 203.A O no hydrogen 2.915 N/A LEU 208.A N PHE 204.A O no hydrogen 2.774 N/A TYR 209.A N GLY 205.A O no hydrogen 3.012 N/A TYR 209.A OH LYS 219.A O no hydrogen 2.434 N/A GLU 210.A N VAL 206.A O no hydrogen 2.838 N/A LEU 211.A N VAL 207.A O no hydrogen 2.915 N/A PHE 212.A N LEU 208.A O no hydrogen 3.152 N/A THR 213.A N TYR 209.A O no hydrogen 2.995 N/A THR 213.A N GLU 210.A O no hydrogen 3.161 N/A THR 213.A OG1 TYR 209.A O no hydrogen 3.528 N/A THR 213.A OG1 GLU 210.A O no hydrogen 2.702 N/A TYR 214.A N LEU 211.A O no hydrogen 3.178 N/A ILE 215.A N THR 213.A OG1 no hydrogen 3.392 N/A SER 218.A OG LYS 217.A O no hydrogen 2.496 N/A ALA 223.A N SER 220.A OG no hydrogen 3.338 N/A GLU 224.A N SER 220.A O no hydrogen 2.924 N/A PHE 225.A N PRO 221.A O no hydrogen 2.848 N/A MET 226.A N PRO 222.A O no hydrogen 2.864 N/A ARG 227.A N ALA 223.A O no hydrogen 2.909 N/A MET 228.A N GLU 224.A O no hydrogen 2.945 N/A ILE 229.A N PHE 225.A O no hydrogen 2.776 N/A GLY 230.A N MET 226.A O no hydrogen 2.606 N/A LYS 233.A N GLY 230.A O no hydrogen 3.050 N/A LYS 233.A NZ ILE 229.A O no hydrogen 3.301 N/A LYS 233.A NZ ASP 232.A OD1 no hydrogen 3.565 N/A ILE 238.A N GLY 235.A O no hydrogen 3.281 N/A PHE 240.A N GLN 236.A O no hydrogen 2.985 N/A HIS 241.A N MET 237.A O no hydrogen 3.127 N/A LEU 242.A N ILE 238.A O no hydrogen 3.020 N/A ILE 243.A N VAL 239.A O no hydrogen 2.986 N/A GLU 244.A N PHE 240.A O no hydrogen 3.112 N/A LEU 245.A N HIS 241.A O no hydrogen 2.741 N/A LEU 246.A N LEU 242.A O no hydrogen 2.825 N/A LYS 247.A N ILE 243.A O no hydrogen 2.787 N/A ASN 248.A ND2 GLU 244.A O no hydrogen 3.165 N/A ASN 249.A N LEU 246.A O no hydrogen 3.124 N/A GLY 250.A N LEU 245.A O no hydrogen 2.789 N/A ARG 251.A NE TRP 270.A O no hydrogen 3.152 N/A ARG 251.A NH1 LEU 246.A O no hydrogen 2.913 N/A ARG 251.A NH1 GLY 250.A O no hydrogen 2.826 N/A ARG 251.A NH2 TRP 270.A O no hydrogen 3.140 N/A ARG 251.A NH2 ASN 272.A OD1 no hydrogen 2.832 N/A ARG 254.A NE CYS 258.A O no hydrogen 2.875 N/A CYS 258.A N PRO 255.A O no hydrogen 3.102 N/A CYS 258.A SG PRO 259.A O no hydrogen 3.641 N/A ILE 262.A N PRO 259.A O no hydrogen 2.919 N/A TYR 263.A N PRO 259.A O no hydrogen 3.086 N/A TYR 263.A OH LEU 252.A O no hydrogen 2.609 N/A MET 264.A N ASP 260.A O no hydrogen 2.871 N/A ILE 265.A N ILE 262.A O no hydrogen 3.055 N/A MET 266.A N ILE 262.A O no hydrogen 3.220 N/A THR 267.A N TYR 263.A O no hydrogen 2.946 N/A THR 267.A OG1 TYR 263.A O no hydrogen 3.442 N/A GLU 268.A N MET 264.A O no hydrogen 3.043 N/A CYS 269.A N ILE 265.A O no hydrogen 3.056 N/A CYS 269.A SG ILE 265.A O no hydrogen 3.316 N/A TRP 270.A N MET 266.A O no hydrogen 2.902 N/A ASN 271.A ND2 GLN 276.A OE1 no hydrogen 3.314 N/A ASN 272.A ND2 LEU 246.A O no hydrogen 3.415 N/A ASN 273.A N ASN 271.A OD1 no hydrogen 2.952 N/A GLN 276.A N ASN 273.A O no hydrogen 2.967 N/A ARG 277.A N VAL 274.A O no hydrogen 3.388 N/A ARG 277.A NE ASN 271.A O no hydrogen 2.708 N/A ARG 277.A NH1 GLU 188.A OE2 no hydrogen 3.054 N/A ARG 277.A NH1 ALA 198.A O no hydrogen 3.000 N/A ARG 277.A NH2 GLU 188.A OE1 no hydrogen 3.110 N/A ARG 277.A NH2 ASN 271.A O no hydrogen 2.987 N/A SER 279.A N ASP 282.A OD2 no hydrogen 3.208 N/A ASP 282.A N SER 279.A OG no hydrogen 3.111 N/A LEU 283.A N SER 279.A O no hydrogen 3.074 N/A ALA 284.A N PHE 280.A O no hydrogen 2.988 N/A LEU 285.A N ARG 281.A O no hydrogen 3.110 N/A ARG 286.A N ASP 282.A O no hydrogen 2.941 N/A ARG 286.A NH1 GLU 268.A OE1 no hydrogen 3.365 N/A ARG 286.A NH1 GLU 268.A OE2 no hydrogen 2.950 N/A VAL 287.A N LEU 283.A O no hydrogen 2.849 N/A ASP 288.A N ALA 284.A O no hydrogen 2.850 N/A GLN 289.A N LEU 285.A O no hydrogen 2.864 N/A ILE 290.A N ARG 286.A O no hydrogen 2.955 N/A ARG 291.A N VAL 287.A O no hydrogen 2.927 N/A ARG 291.A NH1 ASP 288.A OD1 no hydrogen 2.756 N/A ASP 292.A N ASP 288.A O no hydrogen 2.798 N/A ASN 293.A N GLN 289.A O no hydrogen 2.826 N/A MET 294.A N ILE 290.A O no hydrogen 2.956 N/A