Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4e6a_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 2.A NH2 PRO 83.A O no hydrogen 2.981 N/A TYR 6.A N VAL 16.A O no hydrogen 3.063 N/A TYR 6.A OH TYR 20.A O no hydrogen 2.799 N/A LEU 10.A N THR 12.A O no hydrogen 3.002 N/A TRP 14.A N GLN 8.A O no hydrogen 2.662 N/A GLU 15.A N TYR 94.A OH no hydrogen 3.023 N/A VAL 16.A N TYR 6.A O no hydrogen 3.223 N/A GLU 18.A N THR 4.A O no hydrogen 2.830 N/A ARG 19.A NE ASP 34.A OD1 no hydrogen 2.742 N/A ARG 19.A NH2 ASP 34.A OD1 no hydrogen 3.225 N/A ARG 19.A NH2 ASP 34.A OD2 no hydrogen 2.689 N/A TYR 20.A N PRO 17.A O no hydrogen 3.021 N/A TYR 20.A OH ASP 79.A OD2 no hydrogen 2.590 N/A GLN 21.A N PHE 33.A O no hydrogen 2.846 N/A GLN 21.A NE2 GLU 18.A O no hydrogen 2.839 N/A SER 24.A N ALA 31.A O no hydrogen 3.153 N/A VAL 26.A N VAL 29.A O no hydrogen 2.971 N/A SER 28.A N LYS 45.A O no hydrogen 3.245 N/A CYS 30.A N VAL 43.A O no hydrogen 2.850 N/A ALA 31.A N SER 24.A O no hydrogen 3.006 N/A ALA 32.A N VAL 41.A O no hydrogen 2.784 N/A PHE 33.A N GLN 21.A O no hydrogen 2.771 N/A ASP 34.A N LEU 39.A O no hydrogen 2.993 N/A THR 35.A N ARG 19.A O no hydrogen 2.766 N/A THR 35.A OG1 ARG 19.A O no hydrogen 3.026 N/A LYS 36.A N ASP 34.A OD1 no hydrogen 3.214 N/A THR 37.A N ASP 34.A O no hydrogen 3.138 N/A THR 37.A OG1 ASP 34.A OD2 no hydrogen 2.655 N/A GLY 38.A N ASP 34.A O no hydrogen 2.754 N/A LEU 39.A N THR 37.A OG1 no hydrogen 3.352 N/A VAL 41.A N ALA 32.A O no hydrogen 2.830 N/A ALA 42.A N THR 97.A O no hydrogen 2.869 N/A VAL 43.A N CYS 30.A O no hydrogen 2.838 N/A LYS 44.A N LEU 95.A O no hydrogen 2.723 N/A LYS 44.A NZ GLU 62.A OE1 no hydrogen 2.927 N/A LYS 45.A N SER 28.A O no hydrogen 2.938 N/A LYS 45.A NZ ILE 13.A O no hydrogen 2.879 N/A LEU 46.A N VAL 93.A O no hydrogen 3.048 N/A ARG 48.A NH1 GLN 51.A OE1 no hydrogen 3.291 N/A GLN 51.A N ARG 48.A O no hydrogen 3.324 N/A SER 52.A OG HIS 55.A ND1 no hydrogen 2.788 N/A HIS 55.A N SER 52.A OG no hydrogen 3.279 N/A HIS 55.A ND1 SER 52.A OG no hydrogen 2.788 N/A ALA 56.A N SER 52.A O no hydrogen 2.966 N/A LYS 57.A N ILE 53.A O no hydrogen 2.930 N/A LYS 57.A NZ GLU 301.A O no hydrogen 2.536 N/A ARG 58.A N ILE 54.A O no hydrogen 2.984 N/A THR 59.A N HIS 55.A O no hydrogen 2.808 N/A THR 59.A OG1 PRO 49.A O no hydrogen 2.697 N/A THR 59.A OG1 HIS 55.A O no hydrogen 2.942 N/A TYR 60.A N ALA 56.A O no hydrogen 2.947 N/A ARG 61.A N LYS 57.A O no hydrogen 2.712 N/A ARG 61.A NE GLU 301.A OE1 no hydrogen 3.360 N/A ARG 61.A NE GLU 301.A OE2 no hydrogen 2.597 N/A ARG 61.A NH2 GLU 301.A OE1 no hydrogen 2.853 N/A GLU 62.A N ARG 58.A O no hydrogen 2.903 N/A LEU 63.A N THR 59.A O no hydrogen 3.120 N/A ARG 64.A N TYR 60.A O no hydrogen 2.879 N/A ARG 64.A NH1 TYR 60.A OH no hydrogen 2.885 N/A ARG 64.A NH2 ASP 297.A O no hydrogen 2.953 N/A LEU 65.A N ARG 61.A O no hydrogen 3.104 N/A LEU 66.A N GLU 62.A O no hydrogen 3.043 N/A LYS 67.A N LEU 63.A O no hydrogen 3.015 N/A LYS 67.A NZ GLU 317.A O no hydrogen 2.640 N/A LYS 67.A NZ GLU 317.A OE1 no hydrogen 2.736 N/A LYS 67.A NZ SER 320.A OG no hydrogen 3.056 N/A HIS 68.A N ARG 64.A O no hydrogen 3.095 N/A HIS 68.A N LEU 65.A O no hydrogen 2.919 N/A HIS 68.A NE2 ASP 294.A O no hydrogen 2.926 N/A MET 69.A N LEU 65.A O no hydrogen 3.214 N/A LYS 70.A N TYR 129.A OH no hydrogen 2.787 N/A ASN 73.A N HIS 71.A ND1 no hydrogen 2.975 N/A ASN 73.A ND2 GLN 122.A OE1 no hydrogen 3.462 N/A ASN 73.A ND2 LEU 153.A O no hydrogen 3.145 N/A VAL 74.A N HIS 71.A O no hydrogen 3.164 N/A ILE 75.A N ILE 155.A O no hydrogen 2.812 N/A LEU 78.A N VAL 96.A O no hydrogen 2.758 N/A ASP 79.A N VAL 96.A O no hydrogen 3.388 N/A PHE 81.A N TYR 94.A O no hydrogen 3.059 N/A THR 82.A OG1 ASP 92.A O no hydrogen 2.648 N/A ALA 84.A N THR 82.A OG1 no hydrogen 3.336 N/A ARG 85.A N GLU 89.A OE1 no hydrogen 3.114 N/A GLU 89.A N SER 86.A OG no hydrogen 3.246 N/A PHE 90.A N LEU 87.A O no hydrogen 3.151 N/A TYR 94.A N PHE 81.A O no hydrogen 2.988 N/A LEU 95.A N LYS 44.A O no hydrogen 2.899 N/A VAL 96.A N ASP 79.A O no hydrogen 2.877 N/A THR 97.A N ALA 42.A O no hydrogen 2.985 N/A LEU 99.A N ARG 40.A O no hydrogen 3.074 N/A LEU 104.A N PRO 142.A O no hydrogen 3.267 N/A LEU 104.A N LEU 145.A O no hydrogen 2.903 N/A ASN 105.A N ASP 103.A OD1 no hydrogen 2.689 N/A ASN 106.A N ASP 103.A OD1 no hydrogen 3.258 N/A VAL 108.A N LEU 104.A O no hydrogen 3.264 N/A HIS 115.A N THR 112.A OG1 no hydrogen 3.209 N/A VAL 116.A N THR 112.A O no hydrogen 2.984 N/A GLN 117.A N ASP 113.A O no hydrogen 2.893 N/A GLN 117.A NE2 ASP 113.A OD2 no hydrogen 2.937 N/A PHE 118.A N ASP 114.A O no hydrogen 3.197 N/A LEU 119.A N HIS 115.A O no hydrogen 3.025 N/A ILE 120.A N VAL 116.A O no hydrogen 2.907 N/A TYR 121.A N GLN 117.A O no hydrogen 2.869 N/A TYR 121.A OH GLU 290.A OE2 no hydrogen 2.525 N/A GLN 122.A N PHE 118.A O no hydrogen 3.136 N/A GLN 122.A NE2 PHE 118.A O no hydrogen 3.314 N/A GLN 122.A NE2 CYS 151.A O no hydrogen 3.297 N/A ILE 123.A N LEU 119.A O no hydrogen 3.057 N/A LEU 124.A N ILE 120.A O no hydrogen 3.024 N/A ARG 125.A N TYR 121.A O no hydrogen 2.816 N/A ARG 125.A NE ASP 289.A O no hydrogen 2.874 N/A ARG 125.A NH1 GLU 72.A OE1 no hydrogen 3.078 N/A ARG 125.A NH1 ASN 73.A OD1 no hydrogen 2.831 N/A ARG 125.A NH2 GLU 72.A OE2 no hydrogen 3.517 N/A ARG 125.A NH2 ASP 289.A O no hydrogen 2.976 N/A ARG 125.A NH2 ASP 289.A OD1 no hydrogen 3.193 N/A GLY 126.A N GLN 122.A O no hydrogen 3.012 N/A LEU 127.A N ILE 123.A O no hydrogen 2.774 N/A LYS 128.A N LEU 124.A O no hydrogen 2.867 N/A LYS 128.A NZ GLU 290.A O no hydrogen 2.670 N/A TYR 129.A N ARG 125.A O no hydrogen 3.396 N/A TYR 129.A OH HIS 68.A O no hydrogen 3.370 N/A ILE 130.A N GLY 126.A O no hydrogen 3.018 N/A HIS 131.A N LEU 127.A O no hydrogen 2.870 N/A HIS 131.A NE2 ASP 178.A OD2 no hydrogen 2.913 N/A SER 132.A N LYS 128.A O no hydrogen 2.969 N/A SER 132.A OG TYR 129.A O no hydrogen 2.653 N/A ALA 133.A N ILE 130.A O no hydrogen 3.162 N/A ASP 134.A N HIS 131.A O no hydrogen 3.025 N/A ILE 135.A N ILE 130.A O no hydrogen 3.307 N/A HIS 137.A N ASP 178.A OD2 no hydrogen 2.745 N/A HIS 137.A NE2 LEU 156.A O no hydrogen 2.937 N/A ARG 138.A N ASP 178.A OD1 no hydrogen 2.732 N/A ASP 139.A N HIS 137.A ND1 no hydrogen 3.134 N/A LYS 141.A NZ ASP 139.A OD2 no hydrogen 2.853 N/A ASN 144.A N LYS 141.A O no hydrogen 2.883 N/A ASN 144.A ND2 ASP 139.A O no hydrogen 2.519 N/A LEU 145.A N PRO 142.A O no hydrogen 3.227 N/A ALA 146.A N LYS 154.A O no hydrogen 3.003 N/A VAL 147.A N ALA 102.A O no hydrogen 3.250 N/A ASN 148.A N GLU 152.A O no hydrogen 3.027 N/A ASN 148.A ND2 GLU 152.A OE1 no hydrogen 2.814 N/A CYS 151.A N ASN 148.A O no hydrogen 3.217 N/A CYS 151.A SG HIS 115.A NE2 no hydrogen 3.379 N/A GLU 152.A N ASN 148.A OD1 no hydrogen 2.882 N/A LEU 153.A N GLN 122.A OE1 no hydrogen 2.828 N/A LYS 154.A N ALA 146.A O no hydrogen 2.773 N/A LYS 154.A NZ GLU 72.A O no hydrogen 2.903 N/A ILE 155.A N ASN 73.A O no hydrogen 2.762 N/A LEU 156.A N ASN 144.A O no hydrogen 2.886 N/A ARG 159.A NE GLN 204.A OE1 no hydrogen 3.191 N/A ARG 159.A NH2 GLY 198.A O no hydrogen 2.525 N/A TRP 160.A NE1 GLY 198.A O no hydrogen 2.832 N/A TYR 161.A OH GLU 188.A OE1 no hydrogen 2.591 N/A ARG 162.A N ARG 159.A O no hydrogen 3.362 N/A GLU 165.A N GLU 165.A OE1 no hydrogen 2.691 N/A ILE 166.A N ALA 163.A O no hydrogen 3.184 N/A MET 167.A N ALA 163.A O no hydrogen 2.946 N/A LEU 168.A N PRO 164.A O no hydrogen 2.871 N/A TRP 170.A N GLU 165.A O no hydrogen 2.949 N/A ASN 174.A ND2 SER 266.A O no hydrogen 3.502 N/A GLN 175.A NE2 HIS 131.A O no hydrogen 2.809 N/A THR 176.A N ASN 174.A OD1 no hydrogen 2.892 N/A THR 176.A OG1 ASN 174.A OD1 no hydrogen 2.391 N/A THR 176.A OG1 SER 266.A O no hydrogen 3.442 N/A VAL 177.A N ASN 174.A O no hydrogen 3.321 N/A ASP 178.A N GLN 175.A O no hydrogen 3.177 N/A TRP 180.A N THR 176.A O no hydrogen 3.215 N/A SER 181.A N VAL 177.A O no hydrogen 3.396 N/A SER 181.A OG TYR 161.A O no hydrogen 2.620 N/A SER 181.A OG VAL 177.A O no hydrogen 3.456 N/A VAL 182.A N ASP 178.A O no hydrogen 2.914 N/A GLY 183.A N ILE 179.A O no hydrogen 2.959 N/A CYS 184.A N TRP 180.A O no hydrogen 3.018 N/A CYS 184.A SG TRP 160.A O no hydrogen 3.973 N/A CYS 184.A SG TRP 180.A O no hydrogen 3.570 N/A ILE 185.A N SER 181.A O no hydrogen 2.983 N/A MET 186.A N VAL 182.A O no hydrogen 2.787 N/A ALA 187.A N GLY 183.A O no hydrogen 2.960 N/A GLU 188.A N CYS 184.A O no hydrogen 3.182 N/A LEU 189.A N ILE 185.A O no hydrogen 2.971 N/A LEU 190.A N MET 186.A O no hydrogen 3.051 N/A LEU 190.A N ALA 187.A O no hydrogen 3.187 N/A THR 191.A N ALA 187.A O no hydrogen 3.166 N/A THR 191.A OG1 ALA 187.A O no hydrogen 3.120 N/A GLY 192.A N GLU 188.A O no hydrogen 2.818 N/A ARG 193.A N THR 191.A OG1 no hydrogen 3.148 N/A GLY 198.A N PHE 196.A O no hydrogen 2.782 N/A GLY 198.A N GLN 204.A OE1 no hydrogen 3.072 N/A THR 199.A N ASP 203.A OD2 no hydrogen 2.896 N/A THR 199.A OG1 ASP 203.A OD2 no hydrogen 3.267 N/A ASP 203.A N ASP 200.A OD1 no hydrogen 2.761 N/A GLN 204.A N ASP 200.A O no hydrogen 2.916 N/A GLN 204.A NE2 TRP 160.A O no hydrogen 3.646 N/A GLN 204.A NE2 PHE 196.A O no hydrogen 2.891 N/A LEU 205.A N HIS 201.A O no hydrogen 3.108 N/A LYS 206.A N ILE 202.A O no hydrogen 2.993 N/A LEU 207.A N ASP 203.A O no hydrogen 3.027 N/A ILE 208.A N GLN 204.A O no hydrogen 3.011 N/A LEU 209.A N LEU 205.A O no hydrogen 2.838 N/A ARG 210.A N LYS 206.A O no hydrogen 3.030 N/A LEU 211.A N ILE 208.A O no hydrogen 3.066 N/A VAL 212.A N ILE 208.A O no hydrogen 2.871 N/A GLY 213.A N LEU 209.A O no hydrogen 2.530 N/A THR 214.A N MET 238.A O no hydrogen 3.037 N/A THR 214.A OG1 MET 238.A O no hydrogen 3.180 N/A LEU 219.A N GLY 216.A O no hydrogen 2.617 N/A LEU 220.A N GLY 216.A O no hydrogen 3.070 N/A LYS 221.A N ALA 217.A O no hydrogen 3.079 N/A LYS 222.A N LEU 219.A O no hydrogen 2.817 N/A LYS 222.A NZ ASP 265.A OD1 no hydrogen 3.096 N/A LYS 222.A NZ ASP 265.A OD2 no hydrogen 2.613 N/A LYS 222.A NZ ASP 267.A OD2 no hydrogen 2.665 N/A ILE 223.A N LEU 220.A O no hydrogen 3.286 N/A SER 227.A OG SER 225.A OG no hydrogen 3.231 N/A ALA 228.A N SER 225.A OG no hydrogen 3.076 N/A ARG 229.A N SER 225.A O no hydrogen 2.874 N/A ARG 229.A NH1 ILE 223.A O no hydrogen 2.631 N/A ASN 230.A N GLU 226.A O no hydrogen 2.724 N/A ASN 230.A ND2 GLU 226.A OE2 no hydrogen 3.053 N/A TYR 231.A N SER 227.A O no hydrogen 2.836 N/A ILE 232.A N ALA 228.A O no hydrogen 3.039 N/A GLN 233.A N ARG 229.A O no hydrogen 3.036 N/A SER 234.A N ASN 230.A O no hydrogen 3.073 N/A SER 234.A OG ASN 230.A O no hydrogen 3.474 N/A SER 234.A OG TYR 231.A O no hydrogen 2.637 N/A LEU 235.A N ILE 232.A O no hydrogen 3.008 N/A LYS 240.A NZ GLU 259.A OE1 no hydrogen 2.249 N/A MET 241.A N LEU 211.A O no hydrogen 3.141 N/A ASN 245.A N ASN 242.A O no hydrogen 3.262 N/A VAL 246.A N PHE 243.A O no hydrogen 2.666 N/A PHE 247.A N PHE 243.A O no hydrogen 2.897 N/A ALA 250.A N PHE 247.A O no hydrogen 3.197 N/A ASN 251.A ND2 ASP 113.A OD2 no hydrogen 2.738 N/A LEU 253.A N ASN 251.A OD1 no hydrogen 2.965 N/A ALA 254.A N ASN 251.A O no hydrogen 2.994 N/A VAL 255.A N ASN 251.A O no hydrogen 3.169 N/A ASP 256.A N PRO 252.A O no hydrogen 3.092 N/A LEU 257.A N LEU 253.A O no hydrogen 3.047 N/A LEU 258.A N ALA 254.A O no hydrogen 2.804 N/A GLU 259.A N VAL 255.A O no hydrogen 2.951 N/A LYS 260.A N ASP 256.A O no hydrogen 3.253 N/A LYS 260.A N LEU 257.A O no hydrogen 2.955 N/A LYS 260.A NZ ASP 256.A OD2 no hydrogen 3.375 N/A MET 261.A N LEU 257.A O no hydrogen 3.062 N/A MET 261.A N LEU 258.A O no hydrogen 3.227 N/A LEU 262.A N LEU 258.A O no hydrogen 2.898 N/A ASP 267.A N ASP 265.A OD1 no hydrogen 3.010 N/A LYS 268.A N ASP 265.A O no hydrogen 3.052 N/A ARG 269.A N SER 266.A O no hydrogen 3.302 N/A ARG 269.A NE VAL 263.A O no hydrogen 2.845 N/A ARG 269.A NH1 GLU 165.A OE2 no hydrogen 2.740 N/A ARG 269.A NH1 THR 176.A O no hydrogen 3.010 N/A ARG 269.A NH2 GLU 165.A OE1 no hydrogen 3.096 N/A ARG 269.A NH2 GLU 165.A OE2 no hydrogen 3.417 N/A ARG 269.A NH2 VAL 263.A O no hydrogen 2.977 N/A ARG 269.A NH2 LEU 264.A O no hydrogen 3.033 N/A ILE 270.A N LYS 260.A O no hydrogen 3.121 N/A GLN 274.A N THR 271.A OG1 no hydrogen 3.176 N/A ALA 275.A N THR 271.A O no hydrogen 2.889 N/A LEU 276.A N ALA 272.A O no hydrogen 3.084 N/A ALA 277.A N GLN 274.A O no hydrogen 3.149 N/A HIS 278.A N ALA 275.A O no hydrogen 3.121 N/A HIS 278.A NE2 ASP 256.A OD2 no hydrogen 2.600 N/A TYR 280.A N HIS 278.A ND1 no hydrogen 3.168 N/A TYR 280.A OH ASP 113.A OD1 no hydrogen 2.774 N/A PHE 281.A N HIS 278.A O no hydrogen 2.961 N/A ALA 282.A N ALA 279.A O no hydrogen 2.774 N/A GLN 283.A NE2 ASP 114.A OD1 no hydrogen 3.109 N/A GLN 283.A NE2 GLN 117.A OE1 no hydrogen 2.488 N/A TYR 284.A N PHE 281.A O no hydrogen 2.865 N/A TYR 284.A OH ASP 114.A O no hydrogen 2.991 N/A HIS 285.A N PHE 281.A O no hydrogen 2.979 N/A HIS 285.A ND1 GLU 290.A OE2 no hydrogen 2.728 N/A ASP 286.A N GLU 290.A OE2 no hydrogen 3.142 N/A ASP 288.A N ASP 286.A OD1 no hydrogen 3.145 N/A ASP 289.A N ASP 286.A O no hydrogen 2.954 N/A ALA 293.A N SER 132.A OG no hydrogen 2.773 N/A GLN 298.A NE2 ASP 134.A O no hydrogen 3.204 N/A GLN 298.A NE2 TYR 296.A O no hydrogen 3.650 N/A SER 299.A N ASP 297.A OD1 no hydrogen 2.951 N/A SER 299.A OG ASP 297.A OD1 no hydrogen 2.623 N/A GLU 301.A N GLN 298.A O no hydrogen 2.942 N/A SER 302.A N SER 299.A O no hydrogen 2.954 N/A SER 302.A OG SER 299.A O no hydrogen 2.983 N/A ARG 303.A N PHE 300.A O no hydrogen 2.879 N/A ARG 303.A NH2 SER 299.A OG no hydrogen 2.919 N/A LEU 306.A N GLU 309.A OE1 no hydrogen 3.010 N/A GLU 309.A N LEU 306.A O no hydrogen 2.886 N/A TRP 310.A N LEU 306.A O no hydrogen 3.167 N/A LYS 311.A N ILE 307.A O no hydrogen 2.972 N/A SER 312.A N ASP 308.A O no hydrogen 3.052 N/A LEU 313.A N GLU 309.A O no hydrogen 2.947 N/A THR 314.A N TRP 310.A O no hydrogen 2.947 N/A THR 314.A OG1 TRP 310.A O no hydrogen 2.802 N/A TYR 315.A N LYS 311.A O no hydrogen 2.990 N/A ASP 316.A N SER 312.A O no hydrogen 2.923 N/A GLU 317.A N LEU 313.A O no hydrogen 3.171 N/A VAL 318.A N THR 314.A O no hydrogen 2.946 N/A ILE 319.A N TYR 315.A O no hydrogen 2.927 N/A SER 320.A N ASP 316.A O no hydrogen 3.019 N/A SER 320.A OG ASP 316.A O no hydrogen 3.170 N/A SER 320.A OG GLU 317.A O no hydrogen 3.437 N/A PHE 321.A N VAL 318.A O no hydrogen 3.159 N/A