Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4esx_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 8.A N THR 6.A OG1 no hydrogen 3.080 N/A LYS 8.A NZ ASP 39.A OD1 no hydrogen 3.352 N/A LYS 8.A NZ ASP 39.A OD2 no hydrogen 2.691 N/A ILE 9.A N ASP 39.A O no hydrogen 2.908 N/A THR 10.A N ASP 61.A OD2 no hydrogen 3.090 N/A THR 10.A OG1 ASP 61.A OD2 no hydrogen 3.433 N/A PHE 11.A N ALA 41.A O no hydrogen 2.859 N/A LEU 12.A N MET 62.A O no hydrogen 2.911 N/A LEU 13.A N LEU 43.A O no hydrogen 2.967 N/A ASN 14.A ND2 TYR 20.A OH no hydrogen 3.148 N/A ALA 18.A N HIS 21.A ND1 no hydrogen 2.974 N/A HIS 21.A N ALA 18.A O no hydrogen 3.089 N/A HIS 21.A NE2 ASN 14.A OD1 no hydrogen 2.865 N/A ILE 22.A N PRO 19.A O no hydrogen 3.184 N/A VAL 24.A N HIS 21.A O no hydrogen 3.114 N/A TYR 25.A N HIS 21.A O no hydrogen 3.424 N/A TYR 25.A OH GLU 44.A OE1 no hydrogen 2.757 N/A LEU 26.A N ILE 22.A O no hydrogen 2.737 N/A ALA 27.A N PRO 23.A O no hydrogen 3.115 N/A ILE 29.A N TYR 25.A O no hydrogen 2.825 N/A LYS 30.A N LEU 26.A O no hydrogen 2.863 N/A LYS 30.A NZ GLU 243.A OE1 no hydrogen 2.647 N/A LYS 30.A NZ GLU 243.A OE2 no hydrogen 3.010 N/A GLY 31.A N ASN 28.A O no hydrogen 3.160 N/A TYR 32.A N ALA 27.A O no hydrogen 2.744 N/A PHE 33.A N ALA 27.A O no hydrogen 3.276 N/A ASP 35.A N GLY 31.A O no hydrogen 2.923 N/A GLU 36.A N PHE 33.A O no hydrogen 2.866 N/A ASN 37.A N LYS 34.A O no hydrogen 2.864 N/A LEU 38.A N PHE 33.A O no hydrogen 2.823 N/A ALA 41.A N ILE 9.A O no hydrogen 2.718 N/A LEU 43.A N PHE 11.A O no hydrogen 2.732 N/A SER 49.A N ASN 47.A OD1 no hydrogen 2.998 N/A ASP 50.A N ASN 47.A O no hydrogen 2.916 N/A VAL 51.A N PRO 48.A O no hydrogen 3.225 N/A LEU 54.A N ASP 50.A O no hydrogen 3.257 N/A VAL 55.A N VAL 51.A O no hydrogen 2.955 N/A GLY 56.A N THR 52.A O no hydrogen 2.694 N/A SER 57.A N GLU 53.A O no hydrogen 2.925 N/A SER 57.A OG GLU 53.A O no hydrogen 2.766 N/A SER 57.A OG LEU 54.A O no hydrogen 3.177 N/A GLY 58.A N VAL 55.A O no hydrogen 3.022 N/A LYS 59.A N SER 57.A OG no hydrogen 3.321 N/A VAL 60.A N LEU 54.A O no hydrogen 2.909 N/A ASP 61.A N THR 10.A OG1 no hydrogen 3.010 N/A MET 62.A N THR 10.A O no hydrogen 3.038 N/A GLY 63.A N ILE 206.A O no hydrogen 2.942 N/A LEU 64.A N LEU 12.A O no hydrogen 3.007 N/A MET 66.A N THR 202.A O no hydrogen 2.901 N/A VAL 67.A N PHE 200.A O no hydrogen 3.311 N/A THR 69.A N ALA 65.A O no hydrogen 2.971 N/A THR 69.A OG1 ALA 65.A O no hydrogen 2.906 N/A LEU 70.A N MET 66.A O no hydrogen 2.830 N/A ALA 71.A N VAL 67.A O no hydrogen 2.923 N/A ALA 72.A N HIS 68.A O no hydrogen 2.878 N/A LYS 73.A NZ ASP 209.A OD2 no hydrogen 2.830 N/A ALA 74.A N LEU 70.A O no hydrogen 3.127 N/A ARG 75.A N ALA 71.A O no hydrogen 2.906 N/A ARG 75.A N ALA 72.A O no hydrogen 3.097 N/A ARG 75.A NH1 GLU 118.A OE1 no hydrogen 3.191 N/A ARG 75.A NH1 GLU 118.A OE2 no hydrogen 3.121 N/A ARG 75.A NH2 GLU 118.A OE2 no hydrogen 2.922 N/A GLY 76.A N LYS 73.A O no hydrogen 3.040 N/A PHE 77.A N ALA 72.A O no hydrogen 2.910 N/A THR 80.A N ALA 207.A O no hydrogen 2.976 N/A THR 80.A OG1 ASP 209.A OD1 no hydrogen 2.532 N/A SER 81.A N ASN 298.A O no hydrogen 2.842 N/A SER 81.A OG GLY 83.A O no hydrogen 3.435 N/A SER 81.A OG ASN 273.A OD1 no hydrogen 2.746 N/A ILE 82.A N TYR 205.A O no hydrogen 2.837 N/A SER 84.A N LEU 271.A O no hydrogen 2.717 N/A SER 84.A OG ASP 87.A OD1 no hydrogen 2.975 N/A LEU 85.A N ILE 203.A O no hydrogen 2.945 N/A LEU 86.A N ILE 203.A O no hydrogen 3.147 N/A ASP 87.A N TYR 266.A O no hydrogen 2.809 N/A GLU 88.A N THR 202.A OG1 no hydrogen 2.857 N/A THR 91.A OG1 PRO 89.A O no hydrogen 2.958 N/A GLY 92.A N GLY 161.A O no hydrogen 2.952 N/A ILE 93.A N LEU 187.A O no hydrogen 2.832 N/A CYS 94.A N GLY 159.A O no hydrogen 2.656 N/A CYS 94.A SG GLY 92.A O no hydrogen 3.910 N/A TYR 95.A N LYS 185.A O no hydrogen 2.875 N/A GLU 97.A N ASP 183.A O no hydrogen 2.752 N/A GLY 98.A N GLU 97.A OE1 no hydrogen 3.236 N/A SER 99.A N LEU 96.A O no hydrogen 3.340 N/A SER 99.A OG LEU 96.A O no hydrogen 2.936 N/A THR 102.A N SER 107.A OG no hydrogen 2.925 N/A ASP 104.A N THR 102.A OG1 no hydrogen 3.024 N/A GLN 106.A N ASP 104.A OD2 no hydrogen 3.064 N/A GLN 106.A NE2 TYR 131.A O no hydrogen 3.241 N/A SER 107.A N ASP 104.A O no hydrogen 3.073 N/A SER 107.A OG THR 102.A O no hydrogen 3.490 N/A SER 107.A OG ASP 104.A O no hydrogen 2.853 N/A LEU 108.A N PHE 105.A O no hydrogen 2.970 N/A LYS 109.A N GLN 106.A O no hydrogen 3.281 N/A GLY 110.A N ASP 137.A O no hydrogen 2.603 N/A LYS 111.A N LEU 108.A O no hydrogen 3.005 N/A LYS 111.A NZ SER 99.A O no hydrogen 3.187 N/A ARG 112.A N ASP 157.A OD2 no hydrogen 2.802 N/A ARG 112.A NE THR 155.A O no hydrogen 2.967 N/A ARG 112.A NH2 THR 155.A O no hydrogen 2.895 N/A ILE 113.A N VAL 139.A O no hydrogen 2.867 N/A GLY 114.A N CYS 158.A O no hydrogen 2.746 N/A TYR 115.A N VAL 141.A O no hydrogen 2.803 N/A LYS 121.A NZ ASP 125.A OD2 no hydrogen 2.848 N/A ILE 122.A N GLU 118.A O no hydrogen 3.443 N/A GLN 123.A N PHE 119.A O no hydrogen 2.826 N/A GLN 123.A NE2 TYR 284.A OH no hydrogen 3.353 N/A VAL 124.A N GLY 120.A O no hydrogen 2.927 N/A ASP 125.A N LYS 121.A O no hydrogen 2.790 N/A GLU 126.A N ILE 122.A O no hydrogen 3.055 N/A LEU 127.A N GLN 123.A O no hydrogen 3.043 N/A THR 128.A N VAL 124.A O no hydrogen 3.233 N/A THR 128.A N ASP 125.A O no hydrogen 3.339 N/A THR 128.A OG1 ASP 125.A O no hydrogen 2.725 N/A THR 128.A OG1 MET 133.A O no hydrogen 3.428 N/A HIS 130.A N LEU 127.A O no hydrogen 2.901 N/A HIS 130.A NE2 GLU 126.A OE2 no hydrogen 2.588 N/A TYR 131.A N THR 128.A O no hydrogen 2.841 N/A TYR 131.A OH LEU 192.A O no hydrogen 2.932 N/A MET 133.A N THR 128.A O no hydrogen 2.945 N/A THR 134.A N ASP 137.A OD2 no hydrogen 2.911 N/A ASP 136.A N THR 134.A OG1 no hydrogen 3.046 N/A ASP 137.A N THR 134.A O no hydrogen 2.953 N/A TYR 138.A OH ASP 125.A OD1 no hydrogen 2.732 N/A VAL 139.A N LYS 111.A O no hydrogen 2.915 N/A VAL 141.A N ILE 113.A O no hydrogen 2.894 N/A ARG 142.A NE GLY 117.A O no hydrogen 3.028 N/A ARG 142.A NH2 ASN 47.A OD1 no hydrogen 2.987 N/A ARG 142.A NH2 SER 49.A OG no hydrogen 2.853 N/A CYS 143.A N TYR 115.A O no hydrogen 2.701 N/A CYS 143.A SG VAL 141.A O no hydrogen 3.441 N/A GLY 144.A N VAL 116.A O no hydrogen 2.929 N/A ASN 146.A N CYS 143.A O no hydrogen 3.266 N/A ASN 146.A ND2 TYR 150.A OH no hydrogen 3.364 N/A LYS 149.A NZ GLU 153.A OE2 no hydrogen 2.677 N/A TYR 150.A N ASN 146.A O no hydrogen 2.964 N/A ILE 151.A N VAL 147.A O no hydrogen 3.013 N/A LEU 152.A N ALA 148.A O no hydrogen 3.066 N/A GLU 153.A N LYS 149.A O no hydrogen 2.824 N/A GLY 154.A N ILE 151.A O no hydrogen 2.984 N/A THR 155.A N TYR 150.A O no hydrogen 3.018 N/A ILE 156.A N TYR 150.A O no hydrogen 3.421 N/A ASP 157.A N ARG 112.A O no hydrogen 2.860 N/A CYS 158.A SG ARG 112.A O no hydrogen 3.988 N/A GLY 159.A N CYS 94.A O no hydrogen 2.932 N/A ILE 160.A N GLY 114.A O no hydrogen 2.909 N/A GLY 161.A N GLY 92.A O no hydrogen 2.941 N/A ILE 162.A N GLN 166.A OE1 no hydrogen 3.010 N/A GLU 163.A N PHE 90.A O no hydrogen 2.716 N/A ILE 165.A N ILE 162.A O no hydrogen 3.209 N/A GLN 167.A N ILE 162.A O no hydrogen 3.474 N/A GLN 167.A NE2 ALA 184.A O no hydrogen 3.068 N/A GLU 169.A N ILE 165.A O no hydrogen 3.082 N/A LEU 170.A N GLN 166.A O no hydrogen 3.083 N/A GLU 171.A N GLN 167.A O no hydrogen 2.926 N/A GLU 172.A N VAL 168.A O no hydrogen 2.920 N/A ALA 173.A N GLU 169.A O no hydrogen 3.148 N/A LEU 174.A N LEU 170.A O no hydrogen 2.906 N/A LYS 175.A N GLU 171.A O no hydrogen 3.171 N/A LYS 175.A NZ GLU 172.A OE2 no hydrogen 3.346 N/A GLU 176.A N GLU 172.A O no hydrogen 2.956 N/A GLN 177.A N LEU 174.A O no hydrogen 2.915 N/A GLY 178.A N LYS 175.A O no hydrogen 2.976 N/A LYS 179.A N LEU 174.A O no hydrogen 2.834 N/A LYS 179.A NZ GLN 177.A OE1 no hydrogen 2.719 N/A ASN 182.A N ASP 180.A OD1 no hydrogen 2.951 N/A ASN 182.A ND2 ASP 180.A OD1 no hydrogen 3.233 N/A ASP 183.A N ASP 180.A O no hydrogen 3.100 N/A ALA 184.A N SER 181.A O no hydrogen 3.097 N/A LYS 185.A N TYR 95.A O no hydrogen 2.984 N/A LYS 185.A NZ ASN 182.A O no hydrogen 3.080 N/A LEU 187.A N ILE 93.A O no hydrogen 2.906 N/A ARG 188.A NE ASP 190.A OD1 no hydrogen 2.877 N/A ARG 188.A NH1 ASP 190.A OD2 no hydrogen 3.040 N/A ILE 189.A N THR 91.A O no hydrogen 2.999 N/A LEU 192.A N ARG 188.A O no hydrogen 3.044 N/A ALA 193.A N ILE 189.A O no hydrogen 2.871 N/A GLU 194.A N LYS 191.A O no hydrogen 3.187 N/A LEU 195.A N ASP 190.A O no hydrogen 2.798 N/A CYS 198.A SG THR 91.A O no hydrogen 3.661 N/A CYS 201.A N CYS 198.A O no hydrogen 3.028 N/A THR 202.A N CYS 199.A O no hydrogen 3.244 N/A THR 202.A OG1 CYS 199.A O no hydrogen 3.561 N/A ILE 203.A N LEU 86.A O no hydrogen 2.933 N/A TYR 205.A N GLY 83.A O no hydrogen 2.913 N/A ILE 206.A N GLY 63.A O no hydrogen 2.778 N/A ALA 207.A N THR 80.A O no hydrogen 2.990 N/A ASN 208.A N ASP 61.A O no hydrogen 3.066 N/A ASN 208.A ND2 VAL 55.A O no hydrogen 2.968 N/A ASP 209.A N PRO 78.A O no hydrogen 3.081 N/A PHE 211.A N ASN 208.A OD1 no hydrogen 2.953 N/A ILE 212.A N ASN 208.A O no hydrogen 2.970 N/A ALA 213.A N ASP 209.A O no hydrogen 2.993 N/A GLU 214.A N LYS 210.A O no hydrogen 2.985 N/A ASN 215.A N PHE 211.A O no hydrogen 2.827 N/A ASN 215.A ND2 PHE 211.A O no hydrogen 2.968 N/A VAL 219.A N ASN 215.A O no hydrogen 3.209 N/A LYS 220.A N PRO 216.A O no hydrogen 3.135 N/A LYS 221.A N GLN 217.A O no hydrogen 2.945 N/A LYS 221.A NZ GLU 36.A O no hydrogen 2.824 N/A PHE 222.A N ALA 218.A O no hydrogen 2.881 N/A LEU 223.A N VAL 219.A O no hydrogen 3.008 N/A LYS 224.A N LYS 220.A O no hydrogen 2.949 N/A ALA 225.A N LYS 221.A O no hydrogen 2.986 N/A ILE 226.A N PHE 222.A O no hydrogen 2.925 N/A LYS 227.A N LEU 223.A O no hydrogen 2.857 N/A LYS 227.A NZ ASP 231.A OD1 no hydrogen 3.050 N/A LYS 227.A NZ ASP 231.A OD2 no hydrogen 3.221 N/A ARG 228.A N LYS 224.A O no hydrogen 2.958 N/A ARG 228.A NH1 ASP 35.A OD2 no hydrogen 2.970 N/A ALA 229.A N ALA 225.A O no hydrogen 3.017 N/A THR 230.A N ILE 226.A O no hydrogen 2.782 N/A THR 230.A OG1 ILE 226.A O no hydrogen 2.750 N/A ASP 231.A N LYS 227.A O no hydrogen 2.874 N/A TYR 232.A N ARG 228.A O no hydrogen 3.261 N/A MET 233.A N ALA 229.A O no hydrogen 2.945 N/A LEU 234.A N THR 230.A O no hydrogen 3.002 N/A ALA 235.A N ASP 231.A O no hydrogen 3.010 N/A HIS 236.A N TYR 232.A O no hydrogen 2.657 N/A GLU 239.A N GLU 239.A OE1 no hydrogen 2.735 N/A ALA 240.A N HIS 236.A O no hydrogen 2.894 N/A TRP 241.A N PRO 237.A O no hydrogen 2.824 N/A TRP 241.A NE1 THR 257.A OG1 no hydrogen 3.026 N/A ALA 242.A N ARG 238.A O no hydrogen 3.040 N/A GLU 243.A N GLU 239.A O no hydrogen 2.992 N/A TYR 244.A N ALA 240.A O no hydrogen 2.979 N/A TYR 244.A OH ALA 18.A O no hydrogen 2.962 N/A GLY 245.A N TRP 241.A O no hydrogen 2.930 N/A ASN 246.A N ALA 242.A O no hydrogen 2.978 N/A PHE 247.A N TYR 244.A O no hydrogen 3.066 N/A LYS 248.A N TYR 244.A O no hydrogen 2.838 N/A LYS 248.A NZ GLU 44.A OE1 no hydrogen 2.941 N/A LYS 248.A NZ GLU 44.A OE2 no hydrogen 3.387 N/A MET 251.A N LYS 248.A O no hydrogen 2.826 N/A GLN 252.A N PRO 249.A O no hydrogen 2.832 N/A THR 253.A N THR 250.A O no hydrogen 3.387 N/A THR 253.A OG1 THR 250.A O no hydrogen 3.297 N/A ASN 256.A N THR 253.A OG1 no hydrogen 2.987 N/A ASN 256.A ND2 THR 250.A O no hydrogen 2.884 N/A THR 257.A N THR 253.A O no hydrogen 3.012 N/A THR 257.A OG1 THR 253.A O no hydrogen 2.854 N/A LYS 258.A N ASP 254.A O no hydrogen 3.016 N/A LYS 258.A NZ GLU 172.A OE1 no hydrogen 3.349 N/A LYS 259.A N LEU 255.A O no hydrogen 2.999 N/A LYS 259.A NZ GLU 169.A OE1 no hydrogen 2.761 N/A PHE 260.A N ASN 256.A O no hydrogen 2.889 N/A GLN 261.A N THR 257.A O no hydrogen 3.048 N/A ARG 262.A N LYS 258.A O no hydrogen 3.190 N/A ARG 262.A NE GLU 163.A OE2 no hydrogen 3.087 N/A ARG 262.A NH1 GLU 171.A OE1 no hydrogen 3.450 N/A ARG 262.A NH1 GLU 171.A OE2 no hydrogen 2.765 N/A ARG 262.A NH2 GLU 171.A OE1 no hydrogen 2.835 N/A CYS 263.A N LYS 259.A O no hydrogen 2.839 N/A CYS 263.A SG LYS 259.A O no hydrogen 3.304 N/A TYR 264.A OH LEU 234.A O no hydrogen 2.612 N/A TYR 266.A N CYS 263.A O no hydrogen 2.821 N/A TYR 266.A OH GLU 163.A OE1 no hydrogen 2.684 N/A SER 268.A N LEU 85.A O no hydrogen 3.039 N/A LEU 271.A N SER 268.A OG no hydrogen 2.858 N/A TYR 272.A N SER 270.A OG no hydrogen 3.199 N/A TYR 272.A OH TRP 306.A O no hydrogen 2.573 N/A ASN 273.A N ASN 301.A OD1 no hydrogen 2.800 N/A ASN 273.A ND2 ASN 301.A OD1 no hydrogen 3.218 N/A TRP 278.A N VAL 274.A O no hydrogen 3.209 N/A TRP 278.A NE1 ASN 273.A OD1 no hydrogen 3.080 N/A ARG 279.A N HIS 275.A O no hydrogen 3.175 N/A LYS 280.A N ARG 276.A O no hydrogen 3.021 N/A VAL 281.A N ASP 277.A O no hydrogen 3.012 N/A ASN 282.A N TRP 278.A O no hydrogen 2.813 N/A ASN 282.A ND2 TYR 295.A O no hydrogen 2.989 N/A ASN 283.A N ARG 279.A O no hydrogen 3.218 N/A TYR 284.A N LYS 280.A O no hydrogen 3.009 N/A GLY 285.A N VAL 281.A O no hydrogen 2.891 N/A LYS 286.A N ASN 282.A O no hydrogen 2.964 N/A LYS 286.A NZ GLU 293.A O no hydrogen 3.082 N/A LYS 286.A NZ TYR 295.A O no hydrogen 3.320 N/A ARG 287.A N ASN 283.A O no hydrogen 2.908 N/A ARG 287.A NE GLU 126.A OE2 no hydrogen 3.169 N/A ARG 287.A NH1 ALA 193.A O no hydrogen 2.967 N/A ARG 287.A NH2 GLU 126.A OE1 no hydrogen 3.136 N/A ARG 287.A NH2 ALA 193.A O no hydrogen 3.373 N/A LEU 288.A N TYR 284.A O no hydrogen 2.835 N/A ASP 289.A N.A LYS 286.A O no hydrogen 2.855 N/A ASP 289.A N.B LYS 286.A O no hydrogen 2.875 N/A ILE 290.A N GLY 285.A O no hydrogen 3.010 N/A LEU 291.A N GLY 285.A O no hydrogen 3.129 N/A TYR 295.A N PRO 292.A O no hydrogen 3.082 N/A ASN 298.A N ASN 298.A OD1 no hydrogen 2.562 N/A ASN 298.A ND2 THR 69.A O no hydrogen 2.764 N/A ASN 298.A ND2 VAL 79.A O no hydrogen 2.958 N/A THR 300.A N SER 81.A O no hydrogen 2.836 N/A THR 300.A OG1 GLU 302.A OE1 no hydrogen 3.236 N/A ASN 301.A ND2 ASN 273.A O no hydrogen 3.308 N/A GLU 302.A N THR 300.A OG1 no hydrogen 3.209 N/A LEU 304.A N ASN 301.A O no hydrogen 3.196 N/A TRP 306.A NE1 SER 270.A O no hydrogen 2.740 N/A