Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4f6l_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ALA 2.A N TYR 197.A OH no hydrogen 2.945 N/A LEU 7.A N PRO 4.A O no hydrogen 3.368 N/A GLU 9.A N ASN 6.A O no hydrogen 3.068 N/A LEU 10.A N ASN 6.A O no hydrogen 3.222 N/A GLN 11.A N LEU 7.A O no hydrogen 3.009 N/A GLN 11.A NE2 TYR 182.A O no hydrogen 3.077 N/A LYS 12.A N SER 8.A O no hydrogen 3.234 N/A ILE 13.A N LEU 10.A O no hydrogen 3.005 N/A VAL 14.A N LEU 10.A O no hydrogen 3.367 N/A MET 15.A N GLN 11.A O no hydrogen 3.416 N/A SER 16.A N LYS 12.A O no hydrogen 3.193 N/A ARG 17.A N ILE 13.A O no hydrogen 2.919 N/A TYR 18.A N VAL 14.A O no hydrogen 2.816 N/A ASN 19.A N MET 15.A O no hydrogen 3.069 N/A LEU 20.A N ARG 17.A O no hydrogen 3.134 N/A GLY 21.A N TYR 18.A O no hydrogen 3.214 N/A SER 26.A N LEU 23.A O no hydrogen 2.979 N/A SER 26.A OG ASN 279.A O no hydrogen 2.859 N/A SER 28.A OG ASN 279.A OD1 no hydrogen 3.435 N/A HIS 29.A NE2 GLN 277.A OE1 no hydrogen 2.952 N/A ARG 30.A N GLN 277.A O no hydrogen 2.741 N/A ARG 30.A NH2 ASP 115.A O no hydrogen 3.150 N/A THR 35.A N ARG 58.A O no hydrogen 3.290 N/A THR 35.A OG1 SER 56.A OG no hydrogen 2.964 N/A LEU 36.A N THR 116.A O no hydrogen 2.920 N/A LEU 37.A N TYR 60.A O no hydrogen 2.958 N/A THR 38.A N ILE 118.A O no hydrogen 3.385 N/A THR 38.A OG1 HIS 119.A ND1 no hydrogen 2.975 N/A THR 41.A OG1 ALA 40.A O no hydrogen 2.915 N/A GLY 42.A N GLY 39.A O no hydrogen 2.896 N/A ALA 46.A N GLY 42.A O no hydrogen 3.414 N/A ALA 46.A N PHE 43.A O no hydrogen 3.060 N/A TYR 47.A N PHE 43.A O no hydrogen 3.377 N/A LEU 48.A N GLY 45.A O no hydrogen 3.149 N/A ILE 49.A N GLY 45.A O no hydrogen 3.088 N/A ALA 51.A N TYR 47.A O no hydrogen 3.287 N/A ALA 51.A N LEU 48.A O no hydrogen 3.229 N/A LEU 52.A N LEU 48.A O no hydrogen 3.157 N/A GLN 53.A NE2 ASN 94.A OD1 no hydrogen 2.775 N/A SER 56.A OG GLY 33.A O no hydrogen 2.636 N/A SER 56.A OG THR 35.A OG1 no hydrogen 2.964 N/A HIS 57.A N GLY 33.A O no hydrogen 2.836 N/A ILE 59.A N ASN 94.A O no hydrogen 3.474 N/A TYR 60.A N THR 35.A O no hydrogen 2.827 N/A CYS 61.A N GLU 96.A O no hydrogen 2.921 N/A PHE 62.A N LEU 37.A O no hydrogen 2.853 N/A ILE 63.A N ILE 98.A O no hydrogen 3.233 N/A ARG 64.A NH1 ASP 101.A O no hydrogen 2.766 N/A ALA 65.A N GLY 100.A O no hydrogen 3.371 N/A ILE 70.A N ASN 67.A OD1 no hydrogen 3.378 N/A ALA 71.A N ASN 67.A O no hydrogen 3.246 N/A TRP 72.A N GLU 68.A O no hydrogen 3.131 N/A TYR 73.A N GLU 69.A O no hydrogen 3.231 N/A LYS 74.A N ILE 70.A O no hydrogen 2.828 N/A LYS 74.A NZ ARG 64.A O no hydrogen 3.075 N/A LEU 75.A N ALA 71.A O no hydrogen 3.111 N/A MET 76.A N TRP 72.A O no hydrogen 2.818 N/A THR 77.A N TYR 73.A O no hydrogen 3.035 N/A THR 77.A OG1 TYR 73.A O no hydrogen 2.932 N/A ASN 78.A ND2 GLY 42.A O no hydrogen 3.266 N/A LEU 79.A N LEU 75.A O no hydrogen 3.157 N/A ASN 80.A N MET 76.A O no hydrogen 2.883 N/A ASP 81.A N ASN 78.A O no hydrogen 3.215 N/A PHE 83.A N LEU 79.A O no hydrogen 3.036 N/A SER 84.A OG THR 87.A OG1 no hydrogen 2.749 N/A THR 87.A N SER 84.A OG no hydrogen 3.313 N/A THR 87.A OG1 SER 84.A O no hydrogen 3.233 N/A THR 87.A OG1 SER 84.A OG no hydrogen 2.749 N/A VAL 88.A N SER 84.A O no hydrogen 3.011 N/A GLU 89.A N GLU 85.A O no hydrogen 3.289 N/A MET 91.A N THR 87.A O no hydrogen 3.438 N/A LEU 92.A N VAL 88.A O no hydrogen 2.958 N/A LEU 92.A N GLU 89.A O no hydrogen 2.978 N/A SER 93.A N MET 90.A O no hydrogen 3.098 N/A SER 93.A OG MET 90.A O no hydrogen 2.489 N/A ASN 94.A ND2 HIS 57.A O no hydrogen 3.433 N/A GLU 96.A N ILE 59.A O no hydrogen 2.913 N/A ILE 98.A N CYS 61.A O no hydrogen 2.885 N/A GLY 100.A N ILE 63.A O no hydrogen 3.148 N/A ASN 113.A ND2 HIS 151.A O no hydrogen 2.845 N/A MET 114.A N HIS 151.A ND1 no hydrogen 3.034 N/A ASP 115.A N ASN 34.A O no hydrogen 3.131 N/A THR 116.A N ASN 34.A O no hydrogen 3.368 N/A THR 116.A OG1 LEU 32.A O no hydrogen 3.162 N/A ILE 117.A N ARG 154.A O no hydrogen 2.856 N/A ILE 118.A N LEU 36.A O no hydrogen 3.038 N/A HIS 119.A N ILE 156.A O no hydrogen 2.949 N/A HIS 119.A ND1 THR 38.A OG1 no hydrogen 2.975 N/A ALA 120.A N THR 38.A OG1 no hydrogen 2.918 N/A GLY 121.A N THR 38.A OG1 no hydrogen 3.019 N/A GLN 139.A N LYS 135.A O no hydrogen 3.113 N/A GLY 140.A N VAL 136.A O no hydrogen 2.758 N/A THR 141.A N ASN 137.A O no hydrogen 2.766 N/A THR 141.A N VAL 138.A O no hydrogen 3.179 N/A VAL 142.A N VAL 138.A O no hydrogen 2.806 N/A ASP 143.A N GLN 139.A O no hydrogen 3.069 N/A VAL 144.A N THR 141.A O no hydrogen 2.930 N/A ILE 145.A N THR 141.A O no hydrogen 3.122 N/A ARG 146.A N VAL 142.A O no hydrogen 3.219 N/A LEU 147.A N ASP 143.A O no hydrogen 3.342 N/A ALA 148.A N VAL 144.A O no hydrogen 2.795 N/A ALA 148.A N ILE 145.A O no hydrogen 2.836 N/A GLN 149.A N ILE 145.A O no hydrogen 3.006 N/A GLN 150.A N ARG 146.A O no hydrogen 3.317 N/A HIS 152.A N GLN 149.A O no hydrogen 2.993 N/A ALA 153.A N ALA 148.A O no hydrogen 2.945 N/A ARG 154.A N ASP 115.A O no hydrogen 2.712 N/A ARG 154.A NE ASP 211.A OD2 no hydrogen 3.052 N/A ARG 154.A NH1 ALA 276.A O no hydrogen 2.766 N/A ARG 154.A NH1 VAL 278.A O no hydrogen 3.525 N/A LEU 155.A N ASP 211.A O no hydrogen 3.070 N/A ILE 156.A N ILE 117.A O no hydrogen 2.656 N/A TYR 157.A N ARG 213.A O no hydrogen 3.007 N/A VAL 158.A N HIS 119.A O no hydrogen 3.132 N/A SER 159.A N VAL 215.A O no hydrogen 2.988 N/A SER 159.A OG THR 160.A O no hydrogen 3.390 N/A SER 159.A OG GLU 199.A OE2 no hydrogen 2.714 N/A THR 160.A N SER 159.A OG no hydrogen 2.354 N/A THR 160.A OG1 SER 162.A OG no hydrogen 2.402 N/A ILE 161.A N VAL 217.A O no hydrogen 2.809 N/A SER 162.A N THR 160.A OG1 no hydrogen 2.879 N/A SER 162.A OG THR 160.A OG1 no hydrogen 2.402 N/A VAL 163.A N THR 160.A O no hydrogen 3.028 N/A GLY 164.A N ILE 161.A O no hydrogen 3.203 N/A PHE 167.A N GLN 338.A O no hydrogen 2.809 N/A THR 171.A OG1 ASP 168.A O no hydrogen 3.520 N/A THR 171.A OG1 ASP 168.A OD1 no hydrogen 2.592 N/A PHE 176.A N MET 341.A O no hydrogen 2.999 N/A SER 177.A N ASP 180.A OD2 no hydrogen 3.040 N/A SER 177.A OG ASP 180.A OD2 no hydrogen 2.949 N/A GLU 178.A N GLU 178.A OE1 no hydrogen 2.695 N/A ASP 180.A N SER 177.A O no hydrogen 2.837 N/A LYS 183.A N GLN 185.A OE1 no hydrogen 2.763 N/A LYS 183.A NZ ASP 173.A OD1 no hydrogen 2.360 N/A LYS 183.A NZ THR 175.A O no hydrogen 2.420 N/A GLN 185.A N GLN 185.A OE1 no hydrogen 2.614 N/A GLN 185.A NE2 VAL 163.A O no hydrogen 3.529 N/A GLN 185.A NE2 VAL 181.A O no hydrogen 3.251 N/A LEU 186.A N TYR 166.A O no hydrogen 3.054 N/A THR 192.A N SER 189.A OG no hydrogen 3.125 N/A ARG 193.A N SER 189.A O no hydrogen 3.143 N/A SER 194.A N PRO 190.A O no hydrogen 3.246 N/A SER 194.A N TYR 191.A O no hydrogen 3.063 N/A SER 194.A OG TYR 191.A O no hydrogen 3.345 N/A LYS 195.A N TYR 191.A O no hydrogen 3.034 N/A PHE 196.A N THR 192.A O no hydrogen 2.950 N/A TYR 197.A N ARG 193.A O no hydrogen 3.297 N/A SER 198.A N SER 194.A O no hydrogen 3.112 N/A SER 198.A OG TYR 157.A OH no hydrogen 2.573 N/A SER 198.A OG SER 194.A O no hydrogen 2.652 N/A LEU 200.A N PHE 196.A O no hydrogen 3.161 N/A LYS 201.A N TYR 197.A O no hydrogen 2.860 N/A VAL 202.A N SER 198.A O no hydrogen 2.721 N/A LEU 203.A N GLU 199.A O no hydrogen 3.026 N/A GLU 204.A N LEU 200.A O no hydrogen 2.971 N/A VAL 206.A N VAL 202.A O no hydrogen 3.061 N/A VAL 206.A N LEU 203.A O no hydrogen 2.940 N/A ASN 207.A N LEU 203.A O no hydrogen 3.122 N/A ARG 213.A N LEU 155.A O no hydrogen 3.091 N/A ARG 213.A NH1 LEU 275.A O no hydrogen 3.539 N/A ARG 213.A NH1 VAL 278.A O no hydrogen 3.309 N/A ARG 213.A NH2 ASP 211.A OD1 no hydrogen 3.547 N/A ILE 214.A N ILE 283.A O no hydrogen 2.709 N/A VAL 215.A N TYR 157.A O no hydrogen 3.008 N/A ARG 216.A N TYR 285.A O no hydrogen 2.725 N/A ARG 216.A NE GLU 199.A OE1 no hydrogen 3.358 N/A ARG 216.A NE GLU 199.A OE2 no hydrogen 3.053 N/A ARG 216.A NH1 ASP 180.A O no hydrogen 3.209 N/A ARG 216.A NH1 HIS 286.A NE2 no hydrogen 3.104 N/A ARG 216.A NH2 ASP 180.A O no hydrogen 3.019 N/A ARG 216.A NH2 GLU 199.A OE1 no hydrogen 2.710 N/A VAL 217.A N SER 159.A O no hydrogen 3.090 N/A ASN 219.A ND2 ASP 261.A O no hydrogen 3.278 N/A THR 221.A N SER 263.A O no hydrogen 3.051 N/A THR 221.A OG1 SER 222.A O no hydrogen 3.064 N/A SER 222.A OG TRP 228.A O no hydrogen 3.562 N/A TYR 224.A N ASP 266.A OD1 no hydrogen 3.035 N/A ASN 225.A N ASP 266.A OD2 no hydrogen 3.437 N/A ARG 227.A NH1 ASP 81.A O no hydrogen 3.179 N/A HIS 229.A ND1 TYR 372.A OH no hydrogen 3.302 N/A MET 230.A N TYR 372.A OH no hydrogen 3.337 N/A ARG 231.A N TYR 82.A OH no hydrogen 3.290 N/A ARG 231.A NH1 ASP 81.A OD2 no hydrogen 3.430 N/A ILE 233.A N MET 230.A O no hydrogen 3.185 N/A LYS 234.A NZ ILE 376.A O no hydrogen 2.559 N/A THR 235.A N ASN 232.A O no hydrogen 3.080 N/A THR 235.A OG1 ASN 232.A O no hydrogen 3.037 N/A ASN 236.A N ILE 233.A O no hydrogen 3.354 N/A PHE 238.A N ASN 236.A OD1 no hydrogen 3.422 N/A SER 239.A OG ASN 236.A O no hydrogen 3.486 N/A VAL 241.A N PHE 238.A O no hydrogen 3.249 N/A MET 242.A N PHE 238.A O no hydrogen 3.339 N/A MET 242.A N SER 239.A O no hydrogen 3.241 N/A LEU 245.A N MET 242.A O no hydrogen 3.146 N/A ILE 251.A N GLU 308.A O no hydrogen 3.333 N/A ALA 256.A N GLY 252.A O no hydrogen 3.122 N/A MET 258.A N MET 255.A O no hydrogen 3.446 N/A VAL 260.A N MET 293.A O no hydrogen 2.878 N/A SER 263.A OG ASP 261.A OD1 no hydrogen 3.494 N/A VAL 265.A N THR 221.A O no hydrogen 3.183 N/A THR 267.A OG1 ASP 266.A OD1 no hydrogen 3.379 N/A THR 268.A N PHE 264.A O no hydrogen 3.059 N/A THR 268.A OG1 PHE 264.A O no hydrogen 2.970 N/A ALA 269.A N VAL 265.A O no hydrogen 2.838 N/A ARG 270.A N ASP 266.A O no hydrogen 2.902 N/A GLN 271.A N THR 267.A O no hydrogen 2.817 N/A ILE 272.A N THR 268.A O no hydrogen 3.019 N/A VAL 273.A N ALA 269.A O no hydrogen 3.102 N/A ALA 274.A N ARG 270.A O no hydrogen 3.104 N/A LEU 275.A N GLN 271.A O no hydrogen 2.895 N/A ALA 276.A N ILE 272.A O no hydrogen 3.194 N/A ALA 276.A N VAL 273.A O no hydrogen 3.370 N/A GLN 277.A N ALA 274.A O no hydrogen 3.403 N/A GLN 277.A NE2 VAL 273.A O no hydrogen 3.314 N/A ASN 279.A N ASN 279.A OD1 no hydrogen 2.483 N/A THR 280.A OG1 GLN 282.A OE1 no hydrogen 2.878 N/A THR 280.A OG1 TYR 285.A OH no hydrogen 3.328 N/A GLN 282.A N GLN 282.A OE1 no hydrogen 2.510 N/A GLN 282.A NE2 GLY 21.A O no hydrogen 2.586 N/A TYR 285.A N ILE 214.A O no hydrogen 2.770 N/A TYR 285.A OH THR 280.A OG1 no hydrogen 3.328 N/A TYR 285.A OH GLN 282.A O no hydrogen 3.034 N/A HIS 286.A N THR 347.A OG1 no hydrogen 2.961 N/A HIS 286.A ND1 ASP 343.A O no hydrogen 3.051 N/A VAL 287.A N ARG 216.A O no hydrogen 3.023 N/A SER 289.A N SER 263.A OG no hydrogen 3.182 N/A ASN 291.A N SER 289.A OG no hydrogen 3.378 N/A MET 293.A N VAL 260.A O no hydrogen 3.377 N/A VAL 295.A N MET 258.A O no hydrogen 3.221 N/A SER 297.A OG PRO 294.A O no hydrogen 3.348 N/A LEU 298.A N VAL 295.A O no hydrogen 3.214 N/A LEU 299.A N VAL 295.A O no hydrogen 3.093 N/A LEU 299.A N LYS 296.A O no hydrogen 3.084 N/A GLU 300.A N LYS 296.A O no hydrogen 3.166 N/A CYS 301.A N LEU 298.A O no hydrogen 3.395 N/A CYS 301.A SG SER 297.A O no hydrogen 3.694 N/A LYS 303.A N LEU 299.A O no hydrogen 3.297 N/A LYS 303.A NZ LEU 246.A O no hydrogen 2.981 N/A LYS 305.A NZ ASP 249.A OD2 no hydrogen 2.397 N/A LEU 309.A N GLU 308.A OE1 no hydrogen 3.395 N/A VAL 310.A N ILE 251.A O no hydrogen 3.410 N/A SER 314.A N SER 311.A OG no hydrogen 3.169 N/A SER 314.A OG SER 311.A O no hydrogen 3.512 N/A PHE 315.A N ASP 312.A O no hydrogen 3.251 N/A ASN 316.A N ASP 312.A O no hydrogen 3.081 N/A LEU 319.A N PHE 315.A O no hydrogen 2.862 N/A GLN 320.A N ASN 316.A O no hydrogen 3.322 N/A LYS 321.A N GLU 317.A O no hydrogen 3.350 N/A GLN 322.A N LEU 319.A O no hydrogen 3.399 N/A ASP 323.A N GLN 320.A O no hydrogen 3.161 N/A THR 327.A OG1 ASP 244.A OD2 no hydrogen 2.657 N/A THR 327.A OG1 MET 324.A O no hydrogen 3.115 N/A GLY 329.A N GLU 326.A O no hydrogen 3.174 N/A LEU 330.A N GLU 326.A O no hydrogen 3.176 N/A THR 331.A N ILE 328.A O no hydrogen 3.272 N/A SER 332.A N ILE 328.A O no hydrogen 3.057 N/A GLU 336.A N SER 332.A O no hydrogen 3.130 N/A GLN 338.A N PHE 167.A O no hydrogen 2.795 N/A ALA 340.A N THR 165.A O no hydrogen 2.954 N/A ASP 343.A N PHE 176.A O no hydrogen 2.659 N/A THR 344.A OG1 HIS 286.A O no hydrogen 3.479 N/A THR 344.A OG1 THR 344.A O no hydrogen 2.549 N/A THR 345.A N ASP 343.A OD1 no hydrogen 3.401 N/A THR 345.A OG1 ASP 343.A OD1 no hydrogen 3.124 N/A THR 347.A N GLU 178.A OE2 no hydrogen 3.329 N/A THR 347.A OG1 GLU 178.A OE2 no hydrogen 3.188 N/A LEU 348.A N THR 344.A O no hydrogen 3.095 N/A LYS 349.A N THR 345.A O no hydrogen 2.957 N/A MET 351.A N THR 347.A O no hydrogen 2.812 N/A ASN 352.A N LYS 349.A O no hydrogen 3.290 N/A HIS 353.A N ILE 350.A O no hydrogen 2.520 N/A GLU 356.A N SER 355.A OG no hydrogen 2.336 N/A THR 362.A OG1 ASN 363.A OD1 no hydrogen 3.496 N/A THR 362.A OG1 ASN 364.A OD1 no hydrogen 2.500 N/A TRP 365.A NE1 TYR 224.A O no hydrogen 3.251 N/A LEU 366.A N THR 362.A O no hydrogen 3.385 N/A TYR 367.A N ASN 363.A O no hydrogen 3.336 N/A HIS 368.A N ASN 364.A O no hydrogen 2.993 N/A TRP 369.A N TRP 365.A O no hydrogen 2.712 N/A ALA 370.A N LEU 366.A O no hydrogen 2.414 N/A GLN 371.A N TYR 367.A O no hydrogen 2.914 N/A TYR 372.A N HIS 368.A O no hydrogen 2.987 N/A TYR 372.A OH HIS 229.A ND1 no hydrogen 3.302 N/A ILE 373.A N TRP 369.A O no hydrogen 3.302 N/A LYS 374.A N ALA 370.A O no hydrogen 2.890 N/A THR 375.A N GLN 371.A O no hydrogen 2.928 N/A THR 375.A OG1 GLN 371.A O no hydrogen 3.021 N/A THR 375.A OG1 TYR 372.A O no hydrogen 2.944 N/A ILE 376.A N TYR 372.A O no hydrogen 3.074 N/A ASN 378.A N THR 375.A O no hydrogen 3.152 N/A