Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4frz_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 4.A N MET 1.A O no hydrogen 3.315 N/A ILE 5.A N ILE 313.A O no hydrogen 3.150 N/A ARG 6.A N THR 284.A O no hydrogen 2.987 N/A VAL 7.A N ASP 50.A OD1 no hydrogen 2.685 N/A TYR 8.A N MET 286.A O no hydrogen 2.946 N/A TYR 8.A OH ASP 65.A O no hydrogen 2.789 N/A CYS 9.A N ARG 51.A O no hydrogen 2.786 N/A CYS 9.A SG VAL 288.A O no hydrogen 3.819 N/A ARG 10.A N VAL 288.A O no hydrogen 3.230 N/A ARG 10.A NH1 GLN 59.A OE1 no hydrogen 2.818 N/A ARG 10.A NH1 THR 94.A OG1 no hydrogen 3.076 N/A ARG 10.A NH2 ALA 57.A O no hydrogen 3.505 N/A ARG 10.A NH2 GLN 59.A OE1 no hydrogen 2.809 N/A ILE 11.A N PHE 53.A O no hydrogen 2.873 N/A ARG 12.A N VAL 290.A O no hydrogen 3.169 N/A ARG 12.A NE GLY 88.A O no hydrogen 2.554 N/A ARG 12.A NH1 PRO 13.A O no hydrogen 2.868 N/A ARG 12.A NH1 GLU 18.A OE1 no hydrogen 2.809 N/A ARG 12.A NH2 GLU 18.A OE2 no hydrogen 2.588 N/A ASN 15.A N GLU 18.A OE1 no hydrogen 3.462 N/A LYS 17.A N ASN 15.A OD1 no hydrogen 3.314 N/A SER 19.A N ASN 15.A O no hydrogen 2.811 N/A SER 20.A N GLU 16.A O no hydrogen 2.981 N/A SER 20.A OG GLU 16.A O no hydrogen 2.996 N/A SER 20.A OG LYS 17.A O no hydrogen 2.829 N/A GLU 21.A N LYS 17.A O no hydrogen 3.154 N/A GLU 21.A N GLU 18.A O no hydrogen 2.968 N/A ARG 22.A N SER 19.A O no hydrogen 2.838 N/A ARG 22.A NH1 ARG 22.A O no hydrogen 3.301 N/A MET 26.A N PRO 292.A O no hydrogen 2.796 N/A THR 28.A N GLU 36.A O no hydrogen 3.131 N/A VAL 30.A N THR 34.A O no hydrogen 3.061 N/A PHE 33.A N ASP 31.A OD1 no hydrogen 2.674 N/A THR 34.A N ASP 31.A O no hydrogen 3.344 N/A THR 34.A OG1 ASP 31.A OD1 no hydrogen 2.984 N/A THR 34.A OG1 ASP 31.A OD2 no hydrogen 3.274 N/A VAL 35.A N HIS 47.A O no hydrogen 3.301 N/A GLU 36.A N THR 28.A O no hydrogen 3.221 N/A HIS 37.A N LYS 45.A O no hydrogen 3.199 N/A LYS 45.A N HIS 37.A O no hydrogen 2.956 N/A HIS 47.A N VAL 35.A O no hydrogen 2.988 N/A TYR 49.A N PHE 33.A O no hydrogen 2.989 N/A TYR 49.A OH LEU 304.A O no hydrogen 2.675 N/A TYR 49.A OH SER 308.A OG no hydrogen 3.314 N/A ASP 50.A N VAL 7.A O no hydrogen 2.894 N/A ARG 51.A NE GLU 32.A O no hydrogen 3.223 N/A VAL 52.A N GLU 32.A O no hydrogen 3.310 N/A PHE 53.A N CYS 9.A O no hydrogen 2.483 N/A ARG 56.A N ASP 54.A OD2 no hydrogen 2.652 N/A ALA 57.A N ASP 54.A O no hydrogen 3.097 N/A SER 58.A N ASP 61.A OD2 no hydrogen 2.889 N/A GLN 59.A NE2 PHE 93.A O no hydrogen 2.702 N/A GLN 59.A NE2 ASN 101.A O no hydrogen 3.663 N/A ASP 61.A N SER 58.A OG no hydrogen 3.200 N/A ILE 62.A N SER 58.A O no hydrogen 3.110 N/A PHE 63.A N GLN 59.A O no hydrogen 3.053 N/A GLU 64.A N ASP 60.A O no hydrogen 2.975 N/A ASP 65.A N ILE 62.A O no hydrogen 2.832 N/A THR 66.A N PHE 63.A O no hydrogen 3.169 N/A LYS 67.A NZ GLU 111.A OE1 no hydrogen 3.392 N/A LEU 69.A N THR 66.A O no hydrogen 3.109 N/A VAL 70.A N LYS 67.A O no hydrogen 3.223 N/A GLN 71.A NE2 ASP 75.A OD2 no hydrogen 2.834 N/A SER 72.A N TYR 68.A O no hydrogen 3.102 N/A SER 72.A OG TYR 68.A O no hydrogen 3.564 N/A ALA 73.A N LEU 69.A O no hydrogen 3.014 N/A VAL 74.A N VAL 70.A O no hydrogen 3.244 N/A ASP 75.A N SER 72.A O no hydrogen 2.966 N/A GLY 76.A N ALA 73.A O no hydrogen 2.992 N/A TYR 77.A N SER 72.A O no hydrogen 3.377 N/A ASN 78.A ND2 ASP 276.A OD2 no hydrogen 2.949 N/A VAL 79.A N LYS 226.A O no hydrogen 2.701 N/A CYS 80.A N LYS 283.A O no hydrogen 2.924 N/A ILE 81.A N SER 228.A O no hydrogen 2.993 N/A PHE 82.A N LEU 285.A O no hydrogen 3.129 N/A ALA 83.A N VAL 230.A O no hydrogen 3.004 N/A TYR 84.A N PHE 287.A O no hydrogen 2.819 N/A THR 87.A N GLU 236.A OE2 no hydrogen 2.848 N/A THR 87.A OG1 GLU 236.A OE1 no hydrogen 2.939 N/A THR 87.A OG1 GLU 236.A OE2 no hydrogen 3.063 N/A SER 89.A N GLN 86.A O no hydrogen 3.040 N/A SER 89.A OG GLN 86.A O no hydrogen 2.362 N/A SER 89.A OG ASN 289.A O no hydrogen 3.121 N/A LYS 91.A NZ GLY 85.A O no hydrogen 3.248 N/A LYS 91.A NZ GLN 86.A O no hydrogen 3.435 N/A THR 92.A OG1 ASP 231.A OD2 no hydrogen 2.798 N/A THR 94.A N GLY 90.A O no hydrogen 3.133 N/A THR 94.A OG1 GLY 90.A O no hydrogen 2.679 N/A ILE 95.A N LYS 91.A O no hydrogen 2.924 N/A TYR 96.A N THR 92.A O no hydrogen 2.673 N/A GLY 97.A N THR 92.A O no hydrogen 2.820 N/A HIS 98.A N ASN 101.A O no hydrogen 3.116 N/A GLY 103.A N TYR 96.A O no hydrogen 2.839 N/A LEU 104.A N THR 94.A O no hydrogen 2.998 N/A THR 105.A N ILE 95.A O no hydrogen 2.715 N/A THR 105.A OG1 ILE 95.A O no hydrogen 2.975 N/A ARG 107.A N LEU 104.A O no hydrogen 3.217 N/A ARG 107.A NE PRO 102.A O no hydrogen 2.555 N/A ARG 107.A NH2 PRO 102.A O no hydrogen 2.727 N/A ALA 108.A N LEU 104.A O no hydrogen 2.834 N/A THR 109.A N THR 105.A O no hydrogen 2.853 N/A THR 109.A OG1 THR 105.A O no hydrogen 2.818 N/A GLU 111.A N ARG 107.A O no hydrogen 3.149 N/A LEU 112.A N ALA 108.A O no hydrogen 2.979 N/A PHE 113.A N THR 109.A O no hydrogen 3.320 N/A ASN 114.A N LYS 110.A O no hydrogen 2.957 N/A ASN 114.A N GLU 111.A O no hydrogen 3.092 N/A ILE 115.A N GLU 111.A O no hydrogen 2.964 N/A LEU 116.A N LEU 112.A O no hydrogen 3.011 N/A LYS 117.A N PHE 113.A O no hydrogen 3.116 N/A ARG 118.A N ASN 114.A O no hydrogen 3.051 N/A ASP 119.A N ILE 115.A O no hydrogen 3.134 N/A SER 120.A N LYS 117.A O no hydrogen 3.504 N/A SER 120.A OG LEU 116.A O no hydrogen 2.751 N/A ARG 122.A N ASP 119.A O no hydrogen 2.943 N/A PHE 123.A N ASP 119.A O no hydrogen 2.967 N/A SER 124.A N ILE 215.A O no hydrogen 3.006 N/A SER 126.A N GLU 213.A O no hydrogen 3.003 N/A LYS 128.A N VAL 211.A O no hydrogen 3.434 N/A ALA 129.A N ILE 171.A O no hydrogen 2.890 N/A TYR 130.A N SER 209.A O no hydrogen 2.959 N/A VAL 132.A N ILE 207.A O no hydrogen 2.901 N/A GLU 133.A N VAL 140.A O no hydrogen 3.062 N/A LEU 134.A N HIS 205.A O no hydrogen 2.989 N/A TYR 135.A N THR 138.A O no hydrogen 2.933 N/A THR 138.A OG1 GLN 136.A O no hydrogen 3.156 N/A VAL 140.A N GLU 133.A O no hydrogen 2.877 N/A LEU 142.A N MET 131.A O no hydrogen 3.014 N/A LEU 143.A N ASP 141.A OD2 no hydrogen 2.919 N/A LYS 156.A N PHE 164.A O no hydrogen 3.064 N/A LYS 156.A NZ GLU 154.A OE1 no hydrogen 3.404 N/A LYS 156.A NZ GLU 166.A OE2 no hydrogen 3.435 N/A LYS 157.A N VAL 350.A O no hydrogen 2.973 N/A ASP 158.A N MET 162.A O no hydrogen 2.882 N/A LYS 160.A N ASP 158.A OD2 no hydrogen 2.671 N/A GLY 161.A N ASP 158.A O no hydrogen 3.024 N/A MET 162.A N ASP 158.A OD2 no hydrogen 2.937 N/A VAL 163.A N ASP 276.A OD2 no hydrogen 3.229 N/A PHE 164.A N LYS 156.A O no hydrogen 2.667 N/A GLU 166.A N GLU 154.A O no hydrogen 3.061 N/A THR 169.A N ASP 141.A OD1 no hydrogen 2.658 N/A THR 169.A OG1 ASP 141.A OD1 no hydrogen 2.583 N/A ILE 171.A N ALA 129.A O no hydrogen 2.707 N/A ILE 173.A N LEU 127.A O no hydrogen 2.639 N/A SER 174.A N GLU 178.A OE1 no hydrogen 3.328 N/A THR 175.A N GLU 178.A OE1 no hydrogen 3.411 N/A LEU 179.A N LEU 176.A O no hydrogen 2.971 N/A MET 181.A N GLU 177.A O no hydrogen 3.168 N/A ILE 182.A N GLU 178.A O no hydrogen 3.268 N/A LEU 183.A N LEU 179.A O no hydrogen 3.026 N/A GLU 184.A N MET 181.A O no hydrogen 3.169 N/A ARG 185.A N MET 181.A O no hydrogen 3.031 N/A GLY 186.A N ILE 182.A O no hydrogen 2.866 N/A SER 187.A N LEU 183.A O no hydrogen 3.198 N/A SER 187.A OG LEU 183.A O no hydrogen 2.223 N/A GLU 188.A N GLU 184.A O no hydrogen 3.453 N/A ARG 189.A N GLY 186.A O no hydrogen 3.292 N/A ARG 189.A NH1 LEU 144.A O no hydrogen 2.343 N/A ARG 190.A N SER 187.A O no hydrogen 3.248 N/A HIS 191.A N GLU 133.A OE1 no hydrogen 2.959 N/A HIS 191.A N GLU 133.A OE2 no hydrogen 3.279 N/A SER 193.A N GLU 199.A O no hydrogen 2.810 N/A SER 193.A OG ASN 196.A O no hydrogen 2.255 N/A SER 193.A OG GLU 199.A O no hydrogen 2.911 N/A ASN 196.A N SER 193.A OG no hydrogen 2.960 N/A ASN 198.A N ASN 196.A OD1 no hydrogen 2.910 N/A GLU 199.A N ASN 196.A O no hydrogen 3.319 N/A SER 201.A N HIS 191.A O no hydrogen 2.953 N/A ARG 203.A N SER 201.A OG no hydrogen 2.959 N/A SER 204.A OG SER 201.A O no hydrogen 3.217 N/A HIS 205.A N LEU 134.A O no hydrogen 2.854 N/A LEU 206.A N ASP 231.A O no hydrogen 2.976 N/A ILE 207.A N VAL 132.A O no hydrogen 2.943 N/A LEU 208.A N PHE 229.A O no hydrogen 2.967 N/A SER 209.A N TYR 130.A O no hydrogen 2.962 N/A VAL 210.A N LEU 227.A O no hydrogen 2.838 N/A VAL 211.A N LYS 128.A O no hydrogen 2.900 N/A ILE 212.A N GLY 225.A O no hydrogen 2.836 N/A GLU 213.A N SER 126.A O no hydrogen 3.260 N/A SER 214.A N ALA 223.A O no hydrogen 2.797 N/A ILE 215.A N SER 124.A O no hydrogen 3.022 N/A ASP 216.A N SER 221.A O no hydrogen 2.794 N/A LEU 217.A N ARG 122.A O no hydrogen 2.850 N/A GLN 218.A N ASP 216.A OD1 no hydrogen 2.970 N/A THR 219.A N ASP 216.A O no hydrogen 3.081 N/A GLN 220.A N ASP 216.A O no hydrogen 2.674 N/A GLN 220.A NE2 LEU 217.A O no hydrogen 3.085 N/A SER 221.A OG SER 322.A O no hydrogen 2.990 N/A ALA 222.A N SER 322.A O no hydrogen 2.845 N/A ALA 223.A N SER 214.A O no hydrogen 2.883 N/A ARG 224.A N HIS 320.A O no hydrogen 3.023 N/A GLY 225.A N ILE 212.A O no hydrogen 2.727 N/A LYS 226.A N TYR 77.A O no hydrogen 3.086 N/A LYS 226.A NZ TYR 130.A OH no hydrogen 2.992 N/A LYS 226.A NZ VAL 163.A O no hydrogen 3.016 N/A LEU 227.A N VAL 210.A O no hydrogen 2.972 N/A SER 228.A N VAL 79.A O no hydrogen 2.866 N/A PHE 229.A N LEU 208.A O no hydrogen 2.769 N/A VAL 230.A N ILE 81.A O no hydrogen 2.876 N/A ASP 231.A N LEU 206.A O no hydrogen 2.924 N/A ALA 233.A N HIS 205.A ND1 no hydrogen 3.206 N/A GLY 234.A N SER 202.A O no hydrogen 2.839 N/A SER 235.A N GLY 85.A O no hydrogen 3.116 N/A GLU 236.A N GLU 236.A OE2 no hydrogen 2.741 N/A ARG 237.A N GLU 299.A OE2 no hydrogen 3.029 N/A LYS 239.A NZ ARG 237.A O no hydrogen 3.182 N/A SER 241.A OG TYR 135.A O no hydrogen 2.803 N/A SER 241.A OG ARG 203.A O no hydrogen 3.530 N/A LYS 244.A N GLN 240.A O no hydrogen 2.727 N/A SER 245.A N SER 241.A O no hydrogen 2.521 N/A SER 245.A OG HIS 205.A NE2 no hydrogen 2.927 N/A SER 245.A OG SER 241.A O no hydrogen 3.263 N/A SER 245.A OG ILE 242.A O no hydrogen 2.829 N/A LEU 246.A N ILE 242.A O no hydrogen 2.763 N/A ALA 248.A N LYS 244.A O no hydrogen 3.112 N/A LEU 249.A N SER 245.A O no hydrogen 2.991 N/A GLY 250.A N LEU 246.A O no hydrogen 2.768 N/A ASP 251.A N SER 247.A O no hydrogen 3.374 N/A VAL 252.A N ALA 248.A O no hydrogen 2.884 N/A ILE 253.A N LEU 249.A O no hydrogen 2.901 N/A GLY 254.A N GLY 250.A O no hydrogen 2.932 N/A ALA 255.A N ASP 251.A O no hydrogen 3.133 N/A LEU 256.A N VAL 252.A O no hydrogen 3.190 N/A SER 257.A N ILE 253.A O no hydrogen 2.991 N/A SER 257.A OG THR 312.A OG1 no hydrogen 2.955 N/A SER 258.A N GLY 254.A O no hydrogen 2.963 N/A SER 258.A OG GLY 254.A O no hydrogen 3.083 N/A GLY 259.A N LEU 256.A O no hydrogen 3.143 N/A ASN 260.A N ALA 255.A O no hydrogen 2.895 N/A ILE 263.A N GLU 354.A O no hydrogen 2.998 N/A TYR 265.A N ILE 263.A O no hydrogen 2.728 N/A TYR 265.A OH LEU 278.A O no hydrogen 2.664 N/A ARG 266.A N GLU 354.A OE2 no hydrogen 2.923 N/A ARG 266.A NE ILE 352.A O no hydrogen 2.751 N/A ARG 266.A NH1 ILE 352.A O no hydrogen 3.546 N/A ASN 267.A N PRO 264.A O no hydrogen 3.249 N/A HIS 268.A N THR 271.A OG1 no hydrogen 3.242 N/A LYS 269.A NZ ASP 137.A O no hydrogen 2.726 N/A LEU 270.A N HIS 268.A ND1 no hydrogen 3.099 N/A THR 271.A OG1 TYR 265.A O no hydrogen 2.439 N/A THR 271.A OG1 HIS 268.A O no hydrogen 2.805 N/A MET 272.A N HIS 268.A O no hydrogen 3.348 N/A LEU 273.A N LYS 269.A O no hydrogen 2.882 N/A MET 274.A N LEU 270.A O no hydrogen 2.958 N/A SER 275.A N MET 272.A O no hydrogen 3.041 N/A SER 275.A OG THR 271.A O no hydrogen 3.007 N/A SER 275.A OG MET 272.A O no hydrogen 2.339 N/A SER 277.A N ASP 276.A OD1 no hydrogen 2.793 N/A SER 277.A OG ASP 276.A OD1 no hydrogen 3.425 N/A LEU 278.A N MET 274.A O no hydrogen 3.224 N/A GLY 279.A N ASN 315.A OD1 no hydrogen 2.583 N/A ASN 281.A ND2 LYS 160.A O no hydrogen 2.778 N/A ALA 282.A N GLY 280.A O no hydrogen 3.149 N/A LYS 283.A N ASN 78.A O no hydrogen 2.793 N/A LYS 283.A NZ SER 72.A OG no hydrogen 2.945 N/A THR 284.A OG1 SER 277.A O no hydrogen 2.711 N/A LEU 285.A N CYS 80.A O no hydrogen 2.914 N/A MET 286.A N ARG 6.A O no hydrogen 2.967 N/A PHE 287.A N PHE 82.A O no hydrogen 2.791 N/A VAL 288.A N TYR 8.A O no hydrogen 2.937 N/A ASN 289.A N TYR 84.A O no hydrogen 2.836 N/A ASN 289.A ND2 THR 94.A OG1 no hydrogen 2.833 N/A VAL 290.A N ARG 10.A O no hydrogen 3.146 N/A SER 291.A OG GLU 18.A OE2 no hydrogen 3.122 N/A ALA 293.A N SER 291.A OG no hydrogen 3.306 N/A SER 295.A OG GLU 23.A OE1 no hydrogen 2.967 N/A SER 295.A OG GLU 23.A OE2 no hydrogen 3.357 N/A ASN 296.A ND2 GLU 18.A OE2 no hydrogen 2.819 N/A ASN 296.A ND2 SER 291.A OG no hydrogen 2.561 N/A LEU 297.A N GLU 294.A O no hydrogen 3.205 N/A THR 300.A N ASN 296.A O no hydrogen 2.751 N/A THR 300.A OG1 SER 291.A O no hydrogen 3.084 N/A THR 300.A OG1 ASN 296.A O no hydrogen 3.256 N/A TYR 301.A N LEU 297.A O no hydrogen 2.800 N/A ASN 302.A N ASP 298.A O no hydrogen 3.141 N/A SER 303.A N GLU 299.A O no hydrogen 2.951 N/A SER 303.A OG GLU 299.A O no hydrogen 3.275 N/A LEU 304.A N THR 300.A O no hydrogen 3.114 N/A LEU 305.A N TYR 301.A O no hydrogen 3.133 N/A TYR 306.A N ASN 302.A O no hydrogen 2.916 N/A TYR 306.A OH LEU 246.A O no hydrogen 3.348 N/A ALA 307.A N SER 303.A O no hydrogen 2.928 N/A SER 308.A N LEU 304.A O no hydrogen 2.954 N/A SER 308.A OG TYR 49.A OH no hydrogen 3.314 N/A SER 308.A OG LEU 304.A O no hydrogen 3.125 N/A ARG 309.A N LEU 305.A O no hydrogen 3.089 N/A ARG 309.A N TYR 306.A O no hydrogen 3.054 N/A VAL 310.A N TYR 306.A O no hydrogen 3.240 N/A ARG 311.A N ALA 307.A O no hydrogen 2.980 N/A ARG 311.A NE ASP 50.A OD1 no hydrogen 3.312 N/A ARG 311.A NE ASP 50.A OD2 no hydrogen 3.230 N/A ARG 311.A NH2 ASP 50.A OD2 no hydrogen 2.844 N/A THR 312.A N ARG 309.A O no hydrogen 3.240 N/A THR 312.A OG1 SER 257.A OG no hydrogen 2.955 N/A THR 312.A OG1 ARG 309.A O no hydrogen 2.910 N/A ILE 313.A N VAL 310.A O no hydrogen 2.946 N/A ASN 315.A N GLY 3.A O no hydrogen 2.788 N/A ASN 315.A ND2 SER 277.A O no hydrogen 2.628 N/A ASN 315.A ND2 ALA 282.A O no hydrogen 3.150 N/A ASP 316.A N GLY 280.A O no hydrogen 3.396 N/A SER 318.A OG LYS 319.A O no hydrogen 3.530 N/A HIS 320.A N GLY 76.A O no hydrogen 2.913 N/A SER 322.A N ALA 222.A O no hydrogen 2.760 N/A VAL 327.A N SER 323.A O no hydrogen 3.008 N/A ARG 328.A N LYS 324.A O no hydrogen 2.966 N/A LEU 329.A N GLU 325.A O no hydrogen 3.013 N/A LYS 330.A N MET 326.A O no hydrogen 3.136 N/A LYS 331.A N VAL 327.A O no hydrogen 3.189 N/A LEU 332.A N LEU 329.A O no hydrogen 2.971 N/A VAL 333.A N LEU 329.A O no hydrogen 2.989 N/A ALA 334.A N LYS 330.A O no hydrogen 2.820 N/A TYR 335.A N LYS 331.A O no hydrogen 2.874 N/A TRP 336.A N LEU 332.A O no hydrogen 2.849 N/A LYS 337.A N VAL 333.A O no hydrogen 2.995 N/A LYS 337.A NZ GLU 346.A O no hydrogen 2.746 N/A GLN 339.A N TRP 336.A O no hydrogen 2.841 N/A VAL 350.A N LYS 157.A O no hydrogen 2.958 N/A