Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4h2x_B.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 4.A N ASP 2.A OD1 no hydrogen 2.778 N/A ASP 5.A N ASP 2.A O no hydrogen 3.116 N/A HIS 6.A ND1 PRO 3.A O no hydrogen 2.840 N/A LEU 7.A N LEU 4.A O no hydrogen 2.814 N/A ALA 8.A N ASP 5.A O no hydrogen 3.157 N/A LYS 10.A N LEU 7.A O no hydrogen 3.057 N/A LEU 11.A N LEU 7.A O no hydrogen 3.327 N/A LEU 11.A N ALA 8.A O no hydrogen 3.220 N/A PHE 12.A N ALA 8.A O no hydrogen 2.921 N/A HIS 13.A N ALA 22.A O no hydrogen 3.005 N/A GLY 16.A N SER 14.A OG no hydrogen 3.119 N/A GLY 19.A N TYR 21.A OH no hydrogen 3.327 N/A VAL 20.A N SER 17.A O no hydrogen 3.027 N/A ALA 22.A N HIS 13.A O no hydrogen 2.980 N/A THR 24.A N LEU 11.A O no hydrogen 2.971 N/A THR 24.A OG1 LYS 10.A O no hydrogen 2.763 N/A THR 24.A OG1 LEU 11.A O no hydrogen 3.102 N/A TYR 27.A N THR 24.A OG1 no hydrogen 3.407 N/A TYR 27.A OH ASP 269.A O no hydrogen 3.240 N/A TYR 27.A OH ASP 269.A OD1 no hydrogen 2.538 N/A GLU 28.A N THR 24.A O no hydrogen 2.981 N/A SER 29.A N ALA 25.A O no hydrogen 2.957 N/A SER 29.A OG ALA 25.A O no hydrogen 3.540 N/A SER 29.A OG LEU 26.A O no hydrogen 2.686 N/A ILE 30.A N TYR 27.A O no hydrogen 3.054 N/A VAL 31.A N TYR 27.A O no hydrogen 3.095 N/A GLU 32.A N GLU 28.A O no hydrogen 2.943 N/A ARG 33.A N SER 29.A O no hydrogen 3.045 N/A ARG 33.A NE.A LEU 294.A O no hydrogen 2.911 N/A ARG 33.A NH2.A LEU 294.A O no hydrogen 3.485 N/A LEU 34.A N ILE 30.A O no hydrogen 2.902 N/A ALA 35.A N VAL 31.A O no hydrogen 2.965 N/A ALA 36.A N GLU 32.A O no hydrogen 3.004 N/A LEU 37.A N ARG 33.A O no hydrogen 2.914 N/A ILE 38.A N LEU 34.A O no hydrogen 2.952 N/A THR 39.A N ALA 35.A O no hydrogen 2.977 N/A THR 39.A OG1 ALA 35.A O no hydrogen 2.948 N/A SER 40.A N ALA 36.A O no hydrogen 2.932 N/A SER 40.A OG LEU 37.A O no hydrogen 2.563 N/A HIS 41.A N ILE 38.A O no hydrogen 3.094 N/A ARG 42.A N THR 39.A O no hydrogen 2.976 N/A ARG 42.A NH1 ASP 136.A OD2 no hydrogen 2.756 N/A THR 46.A OG1 GLU 43.A O no hydrogen 2.776 N/A GLU 47.A N ARG 134.A O no hydrogen 2.911 N/A LEU 49.A N ASP 136.A O no hydrogen 2.797 N/A ARG 50.A NH1 LEU 49.A O no hydrogen 2.868 N/A ARG 50.A NH1 ASP 136.A O no hydrogen 2.992 N/A ARG 50.A NH1 ASP 136.A OD1 no hydrogen 2.938 N/A ARG 50.A NH2 ASP 136.A OD1 no hydrogen 3.104 N/A ARG 50.A NH2 ASP 136.A OD2 no hydrogen 3.570 N/A PHE 51.A N ALA 138.A O no hydrogen 2.983 N/A MET 55.A N VAL 109.A O no hydrogen 2.860 N/A ARG 57.A N ASP 107.A O no hydrogen 2.896 N/A ARG 57.A NE ALA 106.A O no hydrogen 3.053 N/A ARG 57.A NH1 GLU 61.A OE2 no hydrogen 2.921 N/A ARG 57.A NH2 ALA 106.A O no hydrogen 3.189 N/A GLN 59.A N SER 56.A OG no hydrogen 3.011 N/A LEU 60.A N SER 56.A O no hydrogen 3.079 N/A GLU 61.A N ARG 57.A O no hydrogen 2.888 N/A LYS 62.A N ALA 58.A O no hydrogen 3.041 N/A SER 63.A N GLN 59.A O no hydrogen 3.061 N/A SER 63.A N LEU 60.A O no hydrogen 3.234 N/A SER 63.A OG.A GLN 59.A O no hydrogen 3.392 N/A SER 63.A OG.B LEU 60.A O no hydrogen 2.611 N/A GLY 64.A N GLU 61.A O no hydrogen 3.031 N/A TYR 65.A N LEU 60.A O no hydrogen 3.393 N/A LYS 67.A N GLY 64.A O no hydrogen 3.224 N/A SER 68.A N TYR 65.A O no hydrogen 3.236 N/A SER 68.A OG GLY 64.A O no hydrogen 3.498 N/A PHE 69.A N TYR 65.A O no hydrogen 2.865 N/A ASN 71.A N ASN 71.A OD1 no hydrogen 2.542 N/A LEU 72.A N PHE 69.A O no hydrogen 2.970 N/A CYS 75.A SG.A VAL 76.A O no hydrogen 3.668 N/A CYS 75.A SG.A LEU 108.A O no hydrogen 3.746 N/A VAL 76.A N LEU 108.A O no hydrogen 3.003 N/A GLY 78.A N SER 104.A O no hydrogen 2.923 N/A HIS 80.A ND1 SER 104.A OG no hydrogen 2.651 N/A THR 82.A N GLU 85.A OE1 no hydrogen 2.843 N/A GLU 85.A N THR 82.A OG1 no hydrogen 3.253 N/A ILE 86.A N THR 82.A O no hydrogen 2.938 N/A ASN 87.A N GLU 83.A O no hydrogen 2.946 N/A ALA 88.A N ARG 84.A O no hydrogen 2.937 N/A ALA 89.A N GLU 85.A O no hydrogen 3.007 N/A VAL 90.A N ILE 86.A O no hydrogen 2.994 N/A SER 91.A N ASN 87.A O no hydrogen 2.850 N/A SER 91.A OG ASN 87.A O no hydrogen 2.958 N/A ARG 92.A N ALA 88.A O no hydrogen 2.831 N/A ARG 92.A NH2 THR 101.A OG1 no hydrogen 3.011 N/A ARG 92.A NH2 SER 102.A OG no hydrogen 2.846 N/A PHE 93.A N ALA 89.A O no hydrogen 3.188 N/A ASP 94.A N VAL 90.A O no hydrogen 3.056 N/A ALA 95.A N SER 91.A O no hydrogen 3.133 N/A ALA 95.A N ARG 92.A O no hydrogen 3.067 N/A GLY 96.A N PHE 93.A O no hydrogen 3.238 N/A GLY 97.A N ARG 92.A O no hydrogen 2.729 N/A THR 100.A N ASP 98.A OD1 no hydrogen 3.013 N/A THR 100.A OG1 ASP 98.A OD1 no hydrogen 2.505 N/A THR 100.A OG1 ASP 98.A OD2 no hydrogen 3.281 N/A THR 101.A OG1 ASP 98.A O no hydrogen 3.277 N/A SER 102.A N TRP 99.A O no hydrogen 3.177 N/A LEU 103.A N THR 100.A O no hydrogen 2.981 N/A SER 104.A N GLY 78.A O no hydrogen 2.940 N/A SER 104.A OG HIS 80.A ND1 no hydrogen 2.651 N/A ALA 106.A N VAL 76.A O no hydrogen 2.825 N/A VAL 109.A N MET 55.A O no hydrogen 2.913 N/A LEU 110.A N GLY 74.A O no hydrogen 2.889 N/A SER 111.A N PRO 53.A O no hydrogen 3.006 N/A CYS 115.A N GLU 160.A OE2 no hydrogen 3.151 N/A CYS 115.A SG TYR 119.A OH no hydrogen 3.617 N/A VAL 118.A N CYS 115.A O no hydrogen 2.811 N/A ALA 122.A N VAL 118.A O no hydrogen 2.906 N/A ALA 123.A N TYR 119.A O no hydrogen 2.858 N/A SER 124.A N PRO 120.A O no hydrogen 3.035 N/A SER 124.A OG ILE 121.A O no hydrogen 2.701 N/A ARG 125.A N ALA 122.A O no hydrogen 3.016 N/A ARG 125.A NH1 GLU 47.A OE1 no hydrogen 2.577 N/A ARG 125.A NH2 GLU 47.A OE1 no hydrogen 3.308 N/A ARG 125.A NH2 GLU 47.A OE2 no hydrogen 2.535 N/A GLY 126.A N ALA 123.A O no hydrogen 3.329 N/A LEU 128.A N GLN 252.A O no hydrogen 2.833 N/A GLY 132.A N PRO 129.A O no hydrogen 2.906 N/A LEU 133.A N ILE 164.A O no hydrogen 2.785 N/A ARG 134.A NH1 GLU 43.A OE1 no hydrogen 3.140 N/A ARG 134.A NH1 ALA 44.A O no hydrogen 2.897 N/A ARG 134.A NH2 ALA 44.A O no hydrogen 3.245 N/A PHE 135.A N VAL 162.A O no hydrogen 2.915 N/A ASP 136.A N GLU 47.A O no hydrogen 2.900 N/A VAL 137.A N GLU 160.A O no hydrogen 2.773 N/A ALA 139.A N MET 158.A O no hydrogen 3.117 N/A CYS 141.A N PHE 156.A O no hydrogen 2.765 N/A CYS 141.A SG ALA 139.A O no hydrogen 3.757 N/A PHE 142.A N SER 111.A O no hydrogen 2.779 N/A ARG 143.A N GLN 154.A O no hydrogen 3.024 N/A ARG 143.A NE PRO 112.A O no hydrogen 2.935 N/A ARG 143.A NH2 PRO 112.A O no hydrogen 2.994 N/A ARG 144.A N.A LEU 72.A O no hydrogen 2.781 N/A ARG 144.A N.B LEU 72.A O no hydrogen 2.795 N/A GLU 145.A N ARG 143.A O no hydrogen 2.823 N/A LYS 148.A NZ ASP 18.A OD1 no hydrogen 3.089 N/A LYS 148.A NZ ASP 18.A OD2 no hydrogen 3.216 N/A HIS 149.A N SER 147.A OG no hydrogen 3.018 N/A ARG 152.A N HIS 149.A O no hydrogen 2.987 N/A ARG 152.A NH1 GLU 145.A OE1 no hydrogen 2.705 N/A GLN 154.A N GLY 19.A O no hydrogen 2.814 N/A GLN 154.A NE2 ASP 18.A O no hydrogen 2.772 N/A PHE 156.A N CYS 141.A O no hydrogen 3.030 N/A ARG 157.A N ASP 269.A OD2 no hydrogen 2.979 N/A ARG 157.A NE ASP 269.A OD2 no hydrogen 3.205 N/A ARG 157.A NH1 GLU 28.A OE2.A no hydrogen 2.248 N/A ARG 157.A NH2 GLU 28.A OE1.A no hydrogen 2.833 N/A ARG 157.A NH2 GLU 28.A OE2.A no hydrogen 2.723 N/A ARG 157.A NH2 ASP 269.A OD1 no hydrogen 3.373 N/A MET 158.A N ALA 139.A O no hydrogen 2.945 N/A ARG 159.A N PHE 266.A O no hydrogen 3.129 N/A ARG 159.A NE ASP 136.A OD1 no hydrogen 2.773 N/A ARG 159.A NH1 ALA 35.A O no hydrogen 3.262 N/A ARG 159.A NH1 THR 39.A OG1 no hydrogen 3.286 N/A ARG 159.A NH2 THR 39.A OG1 no hydrogen 2.824 N/A ARG 159.A NH2 ASP 136.A OD1 no hydrogen 3.364 N/A ARG 159.A NH2 ASP 136.A OD2 no hydrogen 2.756 N/A GLU 160.A N VAL 137.A O no hydrogen 2.765 N/A TYR 161.A N VAL 264.A O no hydrogen 2.958 N/A TYR 161.A OH ILE 38.A O no hydrogen 2.868 N/A VAL 162.A N PHE 135.A O no hydrogen 2.830 N/A CYS 163.A N GLY 262.A O no hydrogen 2.864 N/A CYS 163.A SG ASP 169.A O no hydrogen 3.882 N/A ILE 164.A N LEU 133.A O no hydrogen 2.840 N/A GLY 165.A N HIS 260.A O no hydrogen 2.994 N/A THR 166.A N ASP 169.A OD2 no hydrogen 2.948 N/A ASP 169.A N THR 166.A OG1 no hydrogen 3.092 N/A VAL 170.A N THR 166.A O no hydrogen 3.139 N/A SER 171.A N PRO 167.A O no hydrogen 2.914 N/A SER 171.A OG PRO 167.A O no hydrogen 3.240 N/A ASP 172.A N ASP 168.A O no hydrogen 3.062 N/A PHE 173.A N ASP 169.A O no hydrogen 3.113 N/A ARG 174.A N VAL 170.A O no hydrogen 2.949 N/A ARG 174.A NH1 GLN 217.A O no hydrogen 3.225 N/A ARG 174.A NH1 PHE 238.A O no hydrogen 3.377 N/A ARG 174.A NH2 GLN 217.A O no hydrogen 3.121 N/A GLU 175.A N SER 171.A O no hydrogen 3.043 N/A ARG 176.A N ASP 172.A O no hydrogen 2.844 N/A ARG 176.A NE GLU 43.A OE2 no hydrogen 2.824 N/A ARG 176.A NH1 ASP 172.A OD2 no hydrogen 2.816 N/A ARG 176.A NH2 GLU 43.A OE1 no hydrogen 2.839 N/A ARG 176.A NH2 GLU 43.A OE2 no hydrogen 3.378 N/A TRP 177.A N PHE 173.A O no hydrogen 3.033 N/A MET 178.A N ARG 174.A O no hydrogen 2.893 N/A VAL 179.A N GLU 175.A O no hydrogen 3.230 N/A ARG 180.A N ARG 176.A O no hydrogen 3.047 N/A ARG 180.A NH1 GLU 43.A OE2 no hydrogen 2.714 N/A ARG 180.A NH2 GLU 43.A OE2 no hydrogen 3.169 N/A ALA 181.A N TRP 177.A O no hydrogen 2.788 N/A GLN 182.A N MET 178.A O no hydrogen 3.439 N/A GLN 182.A NE2 MET 178.A O no hydrogen 2.991 N/A ALA 183.A N VAL 179.A O no hydrogen 3.066 N/A ILE 184.A N ARG 180.A O no hydrogen 2.997 N/A ALA 185.A N ALA 181.A O no hydrogen 2.932 N/A ARG 186.A N GLN 182.A O no hydrogen 2.968 N/A ASP 187.A N ALA 183.A O no hydrogen 2.957 N/A LEU 188.A N ILE 184.A O no hydrogen 2.937 N/A LEU 188.A N ALA 185.A O no hydrogen 3.281 N/A GLY 189.A N ARG 186.A O no hydrogen 2.915 N/A LEU 190.A N ALA 185.A O no hydrogen 2.931 N/A ARG 193.A N LEU 223.A O no hydrogen 3.014 N/A ARG 193.A NH1 ASP 195.A OD2 no hydrogen 3.163 N/A ASP 195.A N GLU 221.A O no hydrogen 3.089 N/A TYR 196.A N ASP 195.A OD1 no hydrogen 2.925 N/A ALA 197.A N LYS 219.A O no hydrogen 2.802 N/A ASP 199.A N GLN 213.A OE1 no hydrogen 2.656 N/A PHE 202.A N SER 68.A O no hydrogen 2.913 N/A GLY 206.A N GLY 203.A O no hydrogen 2.965 N/A LYS 207.A N GLY 203.A O no hydrogen 3.285 N/A LYS 207.A N ARG 204.A O no hydrogen 3.001 N/A LEU 209.A N ALA 205.A O no hydrogen 3.399 N/A ALA 210.A N GLY 206.A O no hydrogen 2.837 N/A ASN 211.A N LYS 207.A O no hydrogen 2.921 N/A ASN 212.A N MET 208.A O no hydrogen 2.865 N/A GLN 213.A N LEU 209.A O no hydrogen 2.929 N/A GLN 213.A NE2 ASP 199.A OD2 no hydrogen 3.003 N/A ARG 214.A N ALA 210.A O no hydrogen 3.069 N/A ASP 215.A N ASN 211.A O no hydrogen 2.877 N/A GLN 216.A N ASN 212.A O no hydrogen 2.880 N/A GLN 216.A NE2 ASN 212.A O no hydrogen 3.053 N/A GLN 217.A N ARG 214.A O no hydrogen 2.990 N/A LEU 218.A N GLN 213.A O no hydrogen 3.032 N/A LYS 219.A NZ ASP 199.A OD1 no hydrogen 2.710 N/A LYS 219.A NZ ASN 239.A OD1 no hydrogen 3.176 N/A PHE 220.A N PHE 238.A O no hydrogen 2.912 N/A GLU 221.A N ASP 195.A O no hydrogen 2.824 N/A LEU 222.A N MET 236.A O no hydrogen 2.941 N/A LEU 223.A N ARG 193.A O no hydrogen 2.765 N/A ILE 224.A N THR 233.A O no hydrogen 2.866 N/A SER 228.A OG GLU 230.A OE1 no hydrogen 3.454 N/A GLN 231.A N SER 228.A OG no hydrogen 2.882 N/A THR 233.A N ILE 224.A O no hydrogen 2.669 N/A THR 233.A OG1 ASP 151.A OD2 no hydrogen 2.678 N/A CYS 235.A N LEU 222.A O no hydrogen 2.932 N/A CYS 235.A SG THR 233.A O no hydrogen 3.554 N/A SER 237.A N ALA 265.A O no hydrogen 2.997 N/A PHE 238.A N PHE 220.A O no hydrogen 2.790 N/A ASN 239.A N CYS 263.A O no hydrogen 2.804 N/A ASN 239.A ND2 SER 237.A OG no hydrogen 3.089 N/A ASN 239.A ND2 CYS 263.A O no hydrogen 3.435 N/A TYR 240.A N LEU 218.A O no hydrogen 2.716 N/A HIS 241.A N THR 261.A O no hydrogen 2.969 N/A HIS 241.A ND1 THR 261.A OG1 no hydrogen 2.892 N/A ARG 242.A NE.A GLN 216.A OE1 no hydrogen 2.936 N/A ARG 242.A NH2.A GLN 216.A OE1 no hydrogen 2.511 N/A HIS 244.A N HIS 241.A O no hydrogen 3.121 N/A THR 247.A N GLU 243.A O no hydrogen 2.758 N/A THR 247.A OG1 GLU 243.A O no hydrogen 2.776 N/A THR 248.A N HIS 244.A O no hydrogen 3.087 N/A THR 248.A OG1 HIS 244.A O no hydrogen 2.924 N/A TRP 249.A N PHE 245.A O no hydrogen 3.015 N/A TRP 249.A NE1 SER 63.A OG.A no hydrogen 3.100 N/A GLY 250.A N THR 247.A O no hydrogen 3.312 N/A ILE 251.A N GLY 246.A O no hydrogen 2.843 N/A GLN 252.A NE2 GLY 256.A O no hydrogen 2.591 N/A ASP 253.A N GLU 257.A O no hydrogen 2.905 N/A ASN 255.A N ASP 253.A OD1 no hydrogen 2.702 N/A GLY 256.A N ASP 253.A O no hydrogen 2.987 N/A GLU 257.A N ASP 253.A OD1 no hydrogen 3.189 N/A ALA 259.A N ILE 251.A O no hydrogen 2.922 N/A HIS 260.A N GLY 165.A O no hydrogen 2.689 N/A HIS 260.A ND1 TYR 240.A OH no hydrogen 2.629 N/A THR 261.A N ARG 242.A O no hydrogen 3.085 N/A THR 261.A OG1 HIS 241.A ND1 no hydrogen 2.892 N/A GLY 262.A N CYS 163.A O no hydrogen 3.072 N/A CYS 263.A N ASN 239.A O no hydrogen 2.991 N/A CYS 263.A SG GLU 160.A OE1 no hydrogen 3.244 N/A VAL 264.A N TYR 161.A O no hydrogen 2.845 N/A ALA 265.A N SER 237.A O no hydrogen 2.869 N/A PHE 266.A N ARG 159.A O no hydrogen 2.721 N/A GLY 267.A N CYS 235.A O no hydrogen 2.962 N/A MET 268.A N ARG 157.A O no hydrogen 3.116 N/A ARG 270.A NE ASP 151.A O no hydrogen 2.760 N/A ARG 270.A NH1 ALA 234.A O no hydrogen 2.877 N/A ARG 270.A NH2 ASP 151.A O no hydrogen 3.085 N/A LEU 271.A N GLY 267.A O no hydrogen 2.913 N/A ALA 272.A N MET 268.A O no hydrogen 2.943 N/A VAL 273.A N ASP 269.A O no hydrogen 2.942 N/A ALA 274.A N ARG 270.A O no hydrogen 2.881 N/A MET 275.A N LEU 271.A O no hydrogen 2.905 N/A PHE 276.A N ALA 272.A O no hydrogen 3.052 N/A HIS 277.A N VAL 273.A O no hydrogen 2.780 N/A THR 278.A N ALA 274.A O no hydrogen 2.882 N/A THR 278.A OG1 ALA 274.A O no hydrogen 2.703 N/A HIS 279.A N MET 275.A O no hydrogen 2.903 N/A HIS 279.A NE2 LEU 188.A O no hydrogen 2.889 N/A GLY 280.A N PHE 276.A O no hydrogen 2.822 N/A SER 284.A N ASP 282.A OD1 no hydrogen 3.171 N/A SER 284.A OG ASP 282.A OD1 no hydrogen 2.656 N/A SER 284.A OG ASP 282.A OD2 no hydrogen 3.546 N/A ALA 285.A N ASP 282.A O no hydrogen 3.081 N/A TRP 286.A N LEU 283.A O no hydrogen 3.074 N/A TRP 286.A NE1 GLY 280.A O no hydrogen 2.758 N/A ARG 291.A N PRO 287.A O no hydrogen 3.023 N/A ARG 291.A NH1 LEU 283.A O no hydrogen 2.869 N/A ASP 292.A N ALA 288.A O no hydrogen 2.827 N/A ILE 293.A N LYS 289.A O no hydrogen 2.995 N/A LEU 294.A N VAL 290.A O no hydrogen 3.075 N/A LEU 294.A N ARG 291.A O no hydrogen 3.270 N/A GLY 295.A N ASP 292.A O no hydrogen 3.079 N/A LEU 296.A N ARG 291.A O no hydrogen 2.878 N/A