Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4hfm_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 4.A N ILE 31.A O no hydrogen 2.971 N/A ASN 6.A N VAL 29.A O no hydrogen 2.605 N/A ASN 6.A ND2 GLU 99.A OE1 no hydrogen 3.238 N/A ASN 6.A ND2 TYR 101.A O no hydrogen 3.266 N/A LYS 7.A N GLU 100.A OE1 no hydrogen 2.871 N/A LYS 7.A NZ ASN 28.A OD1 no hydrogen 3.554 N/A GLN 8.A N LYS 27.A O no hydrogen 2.644 N/A GLN 8.A NE2 GLU 99.A OE1 no hydrogen 2.977 N/A VAL 9.A N TRP 98.A O no hydrogen 2.769 N/A ILE 10.A N GLU 25.A O no hydrogen 2.724 N/A LEU 11.A N SER 68.A O no hydrogen 3.213 N/A LYS 12.A N ASP 23.A O no hydrogen 2.794 N/A LYS 12.A NZ SER 22.A O no hydrogen 2.707 N/A VAL 15.A N MET 59.A O no hydrogen 2.786 N/A GLY 17.A N GLU 252.A OE2 no hydrogen 2.992 N/A LYS 20.A N ASP 23.A OD2 no hydrogen 2.852 N/A GLU 21.A N GLU 21.A OE1 no hydrogen 2.756 N/A ASP 23.A N LYS 20.A O no hydrogen 2.973 N/A MET 24.A N GLU 21.A O no hydrogen 2.979 N/A GLU 25.A N ILE 10.A O no hydrogen 3.042 N/A LYS 27.A N GLN 8.A O no hydrogen 2.882 N/A VAL 29.A N ASN 6.A O no hydrogen 3.039 N/A ILE 31.A N VAL 4.A O no hydrogen 2.922 N/A LEU 33.A N GLU 2.A O no hydrogen 2.907 N/A LYS 34.A N LYS 32.A O no hydrogen 3.034 N/A SER 39.A N PRO 36.A O no hydrogen 3.000 N/A SER 39.A OG PRO 36.A O no hydrogen 3.014 N/A ASN 40.A ND2 GLY 82.A O no hydrogen 2.794 N/A ASP 41.A N SER 39.A OG no hydrogen 3.319 N/A VAL 42.A N ILE 104.A O.A no hydrogen 2.840 N/A VAL 42.A N ILE 104.A O.B no hydrogen 2.924 N/A VAL 43.A N GLU 80.A O no hydrogen 2.853 N/A VAL 44.A N SER 102.A O no hydrogen 2.812 N/A LYS 45.A N LYS 77.A O no hydrogen 2.793 N/A ASN 46.A N GLU 100.A O no hydrogen 2.956 N/A ASN 46.A ND2 THR 96.A OG1 no hydrogen 2.676 N/A LEU 47.A N VAL 75.A O no hydrogen 2.806 N/A TYR 48.A N VAL 75.A O no hydrogen 3.214 N/A LEU 49.A N VAL 329.A O no hydrogen 2.854 N/A SER 50.A N TYR 73.A O no hydrogen 2.876 N/A SER 50.A OG ASP 52.A OD1 no hydrogen 2.891 N/A SER 50.A OG ASP 52.A OD2 no hydrogen 2.805 N/A CYS 51.A N GLN 327.A O no hydrogen 3.011 N/A MET 55.A N ASP 52.A O no hydrogen 3.088 N/A ARG 56.A N PRO 53.A O no hydrogen 3.090 N/A ARG 56.A NE GLY 17.A O no hydrogen 3.171 N/A ARG 56.A NH1 ARG 56.A O no hydrogen 2.939 N/A ARG 56.A NH2 VAL 15.A O no hydrogen 3.493 N/A ARG 56.A NH2 GLY 17.A O no hydrogen 2.782 N/A SER 57.A N TYR 54.A O no hydrogen 3.013 N/A ARG 58.A N MET 55.A O no hydrogen 2.993 N/A ARG 58.A NE GLU 62.A O no hydrogen 2.668 N/A ARG 58.A NH2 GLU 62.A O no hydrogen 2.932 N/A MET 59.A N ARG 56.A O no hydrogen 3.050 N/A ARG 60.A N SER 57.A O no hydrogen 3.417 N/A ARG 60.A NH2 TYR 249.A O no hydrogen 2.981 N/A ARG 60.A NH2 LEU 251.A O no hydrogen 2.951 N/A SER 63.A OG ARG 60.A O no hydrogen 3.336 N/A SER 63.A OG PHE 64.A O no hydrogen 3.300 N/A PHE 64.A N ARG 58.A O no hydrogen 2.768 N/A GLY 67.A N LEU 11.A O no hydrogen 2.774 N/A SER 68.A N ALA 65.A O no hydrogen 2.929 N/A ILE 70.A N VAL 9.A O no hydrogen 2.940 N/A GLY 72.A N THR 96.A O no hydrogen 3.068 N/A GLY 74.A N GLY 94.A O no hydrogen 2.933 N/A VAL 75.A N TYR 48.A O no hydrogen 2.794 N/A ALA 76.A N VAL 92.A O no hydrogen 2.823 N/A LYS 77.A N LYS 45.A O no hydrogen 2.864 N/A VAL 78.A N ASP 90.A O no hydrogen 2.805 N/A LEU 79.A N VAL 43.A O no hydrogen 2.772 N/A GLU 80.A N VAL 43.A O no hydrogen 3.395 N/A SER 81.A OG ASP 83.A O no hydrogen 2.761 N/A SER 81.A OG PHE 86.A O no hydrogen 2.888 N/A GLY 82.A N ASP 41.A O no hydrogen 2.724 N/A ASP 83.A N SER 81.A OG no hydrogen 2.962 N/A LYS 85.A N ASP 83.A OD1 no hydrogen 2.844 N/A PHE 86.A N ASP 83.A O no hydrogen 2.908 N/A GLN 87.A N ASP 90.A OD2 no hydrogen 3.009 N/A LYS 88.A NZ LEU 79.A O no hydrogen 3.138 N/A GLY 89.A N VAL 78.A O no hydrogen 2.784 N/A ASP 90.A N GLN 87.A O no hydrogen 3.058 N/A VAL 92.A N ALA 76.A O no hydrogen 2.903 N/A TRP 93.A N PHE 109.A O no hydrogen 2.879 N/A TRP 93.A NE1 TYR 282.A OH no hydrogen 2.954 N/A GLY 94.A N GLY 74.A O no hydrogen 3.237 N/A THR 96.A N GLY 72.A O no hydrogen 2.908 N/A THR 96.A OG1 SER 102.A OG no hydrogen 3.265 N/A GLY 97.A N SER 102.A OG no hydrogen 3.051 N/A TRP 98.A N ILE 70.A O no hydrogen 2.816 N/A GLU 99.A N GLY 97.A O no hydrogen 2.896 N/A GLU 100.A N LYS 7.A O no hydrogen 3.018 N/A TYR 101.A N ASN 6.A OD1 no hydrogen 2.979 N/A SER 102.A N VAL 44.A O no hydrogen 2.970 N/A SER 102.A OG ASN 46.A OD1 no hydrogen 2.977 N/A SER 102.A OG THR 96.A OG1 no hydrogen 3.265 N/A SER 102.A OG GLU 99.A OE2 no hydrogen 2.673 N/A ILE 104.A N.A VAL 42.A O no hydrogen 2.747 N/A ILE 104.A N.B VAL 42.A O no hydrogen 2.754 N/A THR 105.A OG1.A ASP 41.A OD1 no hydrogen 3.080 N/A PHE 109.A N TRP 93.A O no hydrogen 2.785 N/A LYS 110.A NZ LYS 85.A O no hydrogen 2.832 N/A LYS 110.A NZ GLN 87.A OE1 no hydrogen 2.788 N/A LYS 110.A NZ ASP 90.A OD2 no hydrogen 2.990 N/A ILE 111.A N LEU 91.A O no hydrogen 2.819 N/A ASP 115.A N ASP 113.A OD1 no hydrogen 2.952 N/A SER 119.A OG GLU 302.A OE1 no hydrogen 3.233 N/A SER 119.A OG GLU 302.A OE2 no hydrogen 2.528 N/A TYR 120.A N PRO 117.A O no hydrogen 2.995 N/A TYR 121.A N LEU 118.A O no hydrogen 3.052 N/A TYR 121.A OH ASP 113.A O no hydrogen 2.721 N/A THR 122.A N SER 119.A O no hydrogen 2.979 N/A THR 122.A OG1 SER 119.A O no hydrogen 2.752 N/A GLY 123.A N TYR 120.A O no hydrogen 2.903 N/A LEU 125.A N TYR 120.A O no hydrogen 2.859 N/A GLY 126.A N GLY 123.A O no hydrogen 2.817 N/A GLY 129.A N GLY 123.A O no hydrogen 2.925 N/A MET 130.A N GLY 126.A O no hydrogen 3.098 N/A THR 131.A N MET 127.A O no hydrogen 2.908 N/A THR 131.A OG1 MET 127.A O no hydrogen 2.724 N/A ALA 132.A N PRO 128.A O no hydrogen 3.005 N/A TYR 133.A N GLY 129.A O no hydrogen 2.928 N/A ALA 134.A N MET 130.A O no hydrogen 2.822 N/A GLY 135.A N THR 131.A O no hydrogen 2.823 N/A PHE 136.A N ALA 132.A O no hydrogen 2.959 N/A HIS 137.A N TYR 133.A O no hydrogen 2.881 N/A HIS 137.A ND1.A GLU 138.A OE2 no hydrogen 2.781 N/A GLU 138.A N ALA 134.A O no hydrogen 2.962 N/A VAL 139.A N ALA 134.A O no hydrogen 3.148 N/A CYS 140.A N GLY 135.A O no hydrogen 3.106 N/A CYS 140.A SG GLY 135.A O no hydrogen 3.464 N/A LYS 143.A N GLU 146.A OE1 no hydrogen 2.936 N/A GLY 145.A N GLY 169.A O no hydrogen 3.017 N/A GLU 146.A N LYS 143.A O no hydrogen 3.163 N/A THR 147.A N ASP 216.A OD2 no hydrogen 2.824 N/A THR 147.A OG1 GLY 214.A O no hydrogen 2.735 N/A THR 147.A OG1 ASP 216.A OD2 no hydrogen 3.340 N/A VAL 148.A N TYR 171.A O no hydrogen 2.748 N/A PHE 149.A N ILE 217.A O no hydrogen 2.869 N/A VAL 150.A N VAL 173.A O no hydrogen 3.015 N/A SER 151.A N PHE 219.A O no hydrogen 3.340 N/A SER 151.A OG TYR 218.A OH no hydrogen 2.676 N/A SER 151.A OG GLU 220.A OE1 no hydrogen 3.549 N/A ALA 153.A N SER 175.A O no hydrogen 3.059 N/A GLY 155.A N ALA 152.A O no hydrogen 3.142 N/A GLN 159.A N GLY 155.A O no hydrogen 3.027 N/A LEU 160.A N VAL 157.A O no hydrogen 3.120 N/A VAL 161.A N VAL 157.A O no hydrogen 3.005 N/A GLY 162.A N GLY 158.A O no hydrogen 3.092 N/A GLN 163.A NE2 GLN 159.A O no hydrogen 3.041 N/A GLN 163.A NE2 VAL 299.A O no hydrogen 2.840 N/A PHE 164.A N LEU 160.A O no hydrogen 2.890 N/A ALA 165.A N VAL 161.A O no hydrogen 2.926 N/A LYS 166.A N GLY 162.A O no hydrogen 2.932 N/A LYS 166.A NZ CYS 170.A O no hydrogen 3.063 N/A LYS 166.A NZ ASP 192.A OD1 no hydrogen 3.120 N/A LYS 166.A NZ ASP 192.A OD2 no hydrogen 2.856 N/A MET 167.A N GLN 163.A O no hydrogen 2.923 N/A LEU 168.A N PHE 164.A O no hydrogen 3.260 N/A LEU 168.A N ALA 165.A O no hydrogen 3.124 N/A GLY 169.A N LYS 166.A O no hydrogen 2.913 N/A CYS 170.A N ALA 165.A O no hydrogen 2.996 N/A CYS 170.A SG LYS 143.A O no hydrogen 3.714 N/A TYR 171.A N GLU 146.A O no hydrogen 3.019 N/A TYR 171.A OH TYR 210.A O no hydrogen 2.749 N/A VAL 172.A N ASP 192.A OD2 no hydrogen 2.863 N/A VAL 173.A N VAL 148.A O no hydrogen 2.897 N/A GLY 174.A N GLU 193.A O no hydrogen 3.218 N/A SER 175.A N VAL 150.A O no hydrogen 3.135 N/A ALA 176.A N PHE 195.A O no hydrogen 3.097 N/A LYS 181.A N SER 178.A OG no hydrogen 3.162 N/A LYS 181.A NZ GLY 321.A O no hydrogen 2.966 N/A LYS 181.A NZ ASN 323.A O no hydrogen 2.786 N/A VAL 182.A N SER 178.A O no hydrogen 2.955 N/A ASP 183.A N LYS 179.A O no hydrogen 2.873 N/A LEU 184.A N GLU 180.A O no hydrogen 3.045 N/A LEU 185.A N LYS 181.A O no hydrogen 2.941 N/A LYS 186.A N VAL 182.A O no hydrogen 3.239 N/A SER 187.A N ASP 183.A O no hydrogen 2.733 N/A SER 187.A OG ASP 183.A O no hydrogen 2.932 N/A LYS 188.A N LEU 184.A O no hydrogen 2.819 N/A PHE 189.A N LEU 184.A O no hydrogen 3.096 N/A PHE 191.A N LEU 185.A O no hydrogen 2.957 N/A ASP 192.A N VAL 172.A O no hydrogen 2.870 N/A GLU 193.A N VAL 172.A O no hydrogen 3.330 N/A PHE 195.A N GLY 174.A O no hydrogen 3.072 N/A TYR 197.A N ALA 176.A O no hydrogen 3.113 N/A LYS 198.A N ASN 196.A OD1 no hydrogen 2.937 N/A LYS 198.A NZ GLY 177.A O no hydrogen 3.017 N/A GLU 199.A N ASN 196.A O no hydrogen 3.092 N/A GLU 200.A N TYR 197.A O no hydrogen 3.418 N/A SER 204.A OG ASP 202.A OD1.A no hydrogen 2.713 N/A SER 204.A OG ASP 202.A OD2.B no hydrogen 2.573 N/A ALA 205.A N ASP 202.A OD1.A no hydrogen 3.103 N/A ALA 205.A N ASP 202.A OD2.B no hydrogen 2.870 N/A ALA 206.A N ASP 202.A O no hydrogen 2.934 N/A LEU 207.A N LEU 203.A O no hydrogen 2.908 N/A LYS 208.A N SER 204.A O no hydrogen 3.029 N/A LYS 208.A NZ PRO 212.A O no hydrogen 3.255 N/A ARG 209.A N ALA 205.A O no hydrogen 3.015 N/A ARG 209.A NH1 GLU 200.A OE1 no hydrogen 3.040 N/A ARG 209.A NH2 GLU 200.A OE1 no hydrogen 3.439 N/A ARG 209.A NH2 GLU 200.A OE2 no hydrogen 2.669 N/A ARG 209.A NH2 TYR 210.A OH no hydrogen 3.137 N/A TYR 210.A N ALA 206.A O no hydrogen 3.188 N/A PHE 211.A N LEU 207.A O no hydrogen 2.711 N/A GLY 214.A N PHE 211.A O no hydrogen 3.000 N/A ILE 215.A N ASN 233.A O no hydrogen 2.847 N/A ASP 216.A N THR 147.A OG1 no hydrogen 2.988 N/A ILE 217.A N THR 147.A O no hydrogen 3.028 N/A TYR 218.A N ARG 239.A O no hydrogen 2.890 N/A TYR 218.A OH SER 151.A OG no hydrogen 2.676 N/A TYR 218.A OH GLU 220.A OE1 no hydrogen 2.430 N/A PHE 219.A N PHE 149.A O no hydrogen 2.905 N/A GLU 220.A N ALA 241.A O no hydrogen 3.031 N/A ASN 221.A N SER 151.A OG no hydrogen 3.048 N/A VAL 222.A N GLU 220.A OE1 no hydrogen 2.970 N/A GLY 223.A N GLU 220.A OE1 no hydrogen 2.767 N/A LEU 227.A N GLY 224.A O no hydrogen 3.013 N/A ASP 228.A N GLY 224.A O no hydrogen 3.412 N/A ALA 229.A N LYS 225.A O no hydrogen 3.045 N/A VAL 230.A N MET 226.A O no hydrogen 2.970 N/A LEU 231.A N LEU 227.A O no hydrogen 2.952 N/A ASN 233.A N VAL 230.A O no hydrogen 2.791 N/A ASN 233.A ND2 SER 204.A O no hydrogen 3.143 N/A ASN 233.A ND2 ALA 229.A O no hydrogen 2.911 N/A MET 234.A N LEU 231.A O no hydrogen 3.383 N/A LYS 235.A N ILE 215.A O no hydrogen 2.844 N/A LYS 235.A NZ ASP 216.A OD2 no hydrogen 3.194 N/A TYR 237.A N LYS 266.A O no hydrogen 2.831 N/A GLY 238.A N LYS 235.A O no hydrogen 3.044 N/A ARG 239.A N ASP 216.A O no hydrogen 2.803 N/A ARG 239.A NE TYR 237.A O no hydrogen 3.045 N/A ARG 239.A NH1 CYS 140.A O no hydrogen 3.289 N/A ARG 239.A NH1 GLU 146.A OE1 no hydrogen 2.971 N/A ARG 239.A NH1 GLU 146.A OE2 no hydrogen 3.372 N/A ARG 239.A NH2 GLU 146.A OE2 no hydrogen 2.938 N/A ILE 240.A N ARG 269.A O no hydrogen 2.810 N/A ALA 241.A N TYR 218.A O no hydrogen 3.011 N/A VAL 242.A N GLU 271.A O no hydrogen 2.771 N/A CYS 243.A N GLU 220.A O no hydrogen 2.967 N/A GLY 244.A N GLU 220.A O no hydrogen 2.922 N/A MET 245.A N TYR 249.A OH no hydrogen 3.096 N/A ILE 246.A N ASN 221.A O no hydrogen 3.102 N/A SER 247.A N VAL 222.A O no hydrogen 3.038 N/A SER 247.A OG VAL 222.A O no hydrogen 2.602 N/A SER 247.A OG GLN 248.A OE1 no hydrogen 3.121 N/A GLN 248.A N MET 245.A O no hydrogen 2.854 N/A TYR 249.A N ILE 246.A O no hydrogen 3.317 N/A ASN 250.A ND2 GLY 17.A O no hydrogen 3.341 N/A LEU 251.A N GLN 248.A O no hydrogen 3.199 N/A HIS 258.A N ASP 228.A OD1 no hydrogen 3.174 N/A HIS 258.A N ASP 228.A OD2 no hydrogen 2.763 N/A ASN 259.A N ASP 228.A OD1 no hydrogen 2.853 N/A ASN 259.A ND2 ASP 228.A O no hydrogen 2.910 N/A CYS 262.A N ASN 259.A O no hydrogen 3.046 N/A CYS 262.A SG LEU 231.A O no hydrogen 3.619 N/A CYS 262.A SG ASN 259.A O no hydrogen 3.516 N/A LEU 263.A N LEU 260.A O no hydrogen 2.901 N/A ILE 264.A N PHE 261.A O no hydrogen 2.973 N/A THR 265.A N PHE 261.A O no hydrogen 3.426 N/A THR 265.A OG1 CYS 262.A O no hydrogen 3.415 N/A LYS 266.A N CYS 262.A O no hydrogen 2.916 N/A LYS 266.A NZ MET 234.A O no hydrogen 2.999 N/A ARG 267.A N ILE 264.A O no hydrogen 3.203 N/A ARG 267.A NH1 THR 265.A O no hydrogen 2.935 N/A ILE 268.A N LEU 263.A O no hydrogen 3.027 N/A ARG 269.A N GLY 238.A O no hydrogen 3.066 N/A ARG 269.A NH1 VAL 139.A O no hydrogen 2.795 N/A ARG 269.A NH1 GLU 271.A OE1 no hydrogen 2.864 N/A ARG 269.A NH2 VAL 139.A O no hydrogen 2.970 N/A GLU 271.A N ILE 240.A O no hydrogen 2.937 N/A ASP 277.A N LEU 274.A O no hydrogen 2.902 N/A TYR 278.A N VAL 275.A O no hydrogen 2.871 N/A LEU 281.A N TYR 278.A O no hydrogen 2.839 N/A TYR 282.A N TYR 279.A O no hydrogen 2.927 N/A TYR 282.A OH LEU 125.A O no hydrogen 2.594 N/A TYR 285.A N LEU 281.A O no hydrogen 2.985 N/A TYR 285.A OH ILE 124.A O no hydrogen 2.746 N/A LEU 286.A N TYR 282.A O no hydrogen 2.918 N/A GLU 287.A N PRO 283.A O no hydrogen 2.960 N/A MET 288.A N LYS 284.A O no hydrogen 2.993 N/A VAL 289.A N TYR 285.A O no hydrogen 2.700 N/A ILE 290.A N LEU 286.A O no hydrogen 3.080 N/A ILE 293.A N VAL 289.A O no hydrogen 2.865 N/A LYS 294.A N ILE 290.A O no hydrogen 2.985 N/A LYS 294.A NZ ASP 113.A OD2 no hydrogen 2.894 N/A ALA 295.A N PRO 291.A O no hydrogen 2.920 N/A GLY 296.A N ILE 293.A O no hydrogen 2.985 N/A LYS 297.A N GLN 292.A O no hydrogen 2.841 N/A VAL 298.A N GLN 292.A O no hydrogen 3.286 N/A VAL 299.A N GLN 163.A OE1 no hydrogen 2.871 N/A TYR 300.A OH ALA 156.A O no hydrogen 2.917 N/A ASP 303.A N LYS 326.A O no hydrogen 2.782 N/A ALA 305.A N VAL 328.A O no hydrogen 2.862 N/A GLY 307.A N MET 330.A O no hydrogen 2.752 N/A GLU 309.A N GLU 309.A OE1 no hydrogen 2.791 N/A SER 310.A N GLY 307.A O no hydrogen 2.890 N/A SER 310.A OG HIS 306.A O no hydrogen 3.031 N/A ALA 311.A N LEU 308.A O no hydrogen 2.890 N/A ALA 314.A N SER 310.A O no hydrogen 3.013 N/A LEU 315.A N ALA 311.A O no hydrogen 2.897 N/A VAL 316.A N PRO 312.A O no hydrogen 3.016 N/A GLY 317.A N THR 313.A O no hydrogen 2.998 N/A LEU 318.A N LEU 315.A O no hydrogen 3.200 N/A PHE 319.A N VAL 316.A O no hydrogen 3.074 N/A SER 320.A N GLY 317.A O no hydrogen 3.218 N/A SER 320.A OG GLY 317.A O no hydrogen 3.499 N/A GLY 321.A N LEU 318.A O no hydrogen 3.274 N/A ARG 322.A N GLY 317.A O no hydrogen 2.883 N/A ILE 324.A N ASP 303.A OD1 no hydrogen 2.984 N/A LYS 326.A N VAL 301.A O no hydrogen 3.230 N/A LYS 326.A NZ SER 50.A OG no hydrogen 2.606 N/A LYS 326.A NZ GLN 327.A O no hydrogen 2.862 N/A GLN 327.A NE2 VAL 328.A O no hydrogen 3.208 N/A VAL 328.A N ASP 303.A O no hydrogen 2.795 N/A VAL 329.A N LEU 49.A O no hydrogen 2.777 N/A MET 330.A N ALA 305.A O no hydrogen 2.737 N/A VAL 331.A N LEU 47.A O no hydrogen 2.770 N/A ARG 333.A NE SER 332.A O no hydrogen 2.777 N/A