Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4i12_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASP 3.A N SER 157.A OG no hydrogen 2.876 N/A ASN 4.A ND2 HIS 88.A O no hydrogen 2.889 N/A ASN 4.A ND2 MET 158.A O no hydrogen 2.719 N/A LEU 5.A N GLY 156.A O no hydrogen 2.999 N/A ARG 6.A N TYR 14.A O no hydrogen 3.150 N/A LYS 8.A N GLY 12.A O no hydrogen 3.234 N/A GLN 11.A N LYS 8.A O no hydrogen 3.440 N/A GLY 12.A N LYS 8.A O no hydrogen 2.645 N/A TYR 13.A OH CYS 154.A O no hydrogen 2.906 N/A TYR 13.A OH GLU 319.A OE1 no hydrogen 2.557 N/A TYR 14.A N ARG 6.A O no hydrogen 2.913 N/A VAL 15.A N ILE 28.A O no hydrogen 2.806 N/A MET 17.A N LEU 26.A O no hydrogen 2.934 N/A THR 18.A N SER 85.A O no hydrogen 2.904 N/A THR 18.A OG1 SER 85.A O no hydrogen 3.225 N/A VAL 19.A N GLN 24.A O no hydrogen 2.744 N/A GLY 20.A N LEU 83.A O no hydrogen 2.763 N/A SER 21.A N THR 58.A OG1 no hydrogen 3.080 N/A GLN 24.A N VAL 19.A O no hydrogen 2.975 N/A GLN 24.A NE2 GLN 52.A O no hydrogen 2.865 N/A LEU 26.A N MET 17.A O no hydrogen 2.813 N/A ASN 27.A N GLU 115.A OE2 no hydrogen 2.823 N/A ASN 27.A ND2 ASN 113.A O no hydrogen 3.306 N/A ILE 28.A N VAL 15.A O no hydrogen 2.931 N/A LEU 29.A N GLY 116.A O no hydrogen 2.840 N/A VAL 30.A N TYR 13.A O no hydrogen 2.806 N/A ASP 31.A N LEU 118.A O no hydrogen 2.945 N/A THR 32.A N SER 213.A OG no hydrogen 2.923 N/A THR 32.A OG1 VAL 211.A O no hydrogen 2.841 N/A GLY 33.A N ASP 31.A OD2 no hydrogen 2.895 N/A SER 34.A OG ASP 31.A OD1 no hydrogen 2.564 N/A SER 35.A OG TYR 122.A O no hydrogen 2.547 N/A ASN 36.A ND2 ARG 127.A O no hydrogen 2.827 N/A ALA 38.A N ILE 117.A O no hydrogen 3.008 N/A VAL 39.A N ALA 99.A O no hydrogen 2.809 N/A GLY 40.A N GLU 115.A O no hydrogen 2.711 N/A ALA 41.A N ILE 101.A O no hydrogen 2.955 N/A PHE 46.A N HIS 44.A ND1 no hydrogen 2.966 N/A LEU 47.A N HIS 44.A O no hydrogen 2.943 N/A TYR 51.A N GLY 40.A O no hydrogen 2.750 N/A TYR 51.A OH ASP 82.A OD2 no hydrogen 2.619 N/A GLN 52.A N GLN 24.A OE1 no hydrogen 2.734 N/A GLN 54.A N GLN 54.A OE1 no hydrogen 2.766 N/A GLN 54.A NE2 GLN 52.A OE1 no hydrogen 3.406 N/A LEU 55.A N GLN 52.A O no hydrogen 3.059 N/A SER 56.A N ARG 53.A O no hydrogen 3.052 N/A SER 56.A OG THR 58.A OG1 no hydrogen 3.217 N/A SER 56.A OG ASP 82.A OD1 no hydrogen 3.295 N/A SER 56.A OG ASP 82.A OD2 no hydrogen 2.618 N/A SER 57.A N SER 21.A O no hydrogen 2.803 N/A SER 57.A OG SER 21.A O no hydrogen 2.505 N/A THR 58.A N SER 56.A OG no hydrogen 3.304 N/A THR 58.A OG1 SER 56.A OG no hydrogen 3.217 N/A THR 58.A OG1 ASP 82.A OD1 no hydrogen 2.653 N/A TYR 59.A N SER 56.A O no hydrogen 3.460 N/A ARG 60.A N THR 81.A O no hydrogen 2.822 N/A LEU 62.A N LEU 79.A O no hydrogen 2.996 N/A ARG 63.A N ASP 61.A OD1 no hydrogen 2.631 N/A VAL 66.A N GLY 77.A O no hydrogen 3.072 N/A VAL 68.A N TRP 75.A O no hydrogen 2.743 N/A TYR 70.A N GLY 73.A O no hydrogen 2.946 N/A LYS 74.A N ASP 105.A O no hydrogen 2.837 N/A LYS 74.A NZ TYR 67.A OH no hydrogen 3.258 N/A TRP 75.A N VAL 68.A O no hydrogen 3.110 N/A GLU 76.A N GLU 103.A O no hydrogen 2.995 N/A GLY 77.A N VAL 66.A O no hydrogen 3.087 N/A GLU 78.A N ALA 100.A O no hydrogen 2.920 N/A LEU 79.A N LYS 64.A O no hydrogen 2.969 N/A GLY 80.A N ILE 98.A O no hydrogen 3.090 N/A THR 81.A N ARG 60.A O no hydrogen 2.869 N/A ASP 82.A N ALA 96.A O no hydrogen 3.132 N/A LEU 83.A N ASP 82.A OD1 no hydrogen 2.791 N/A VAL 84.A N VAL 94.A O no hydrogen 2.745 N/A SER 85.A N THR 18.A O no hydrogen 2.849 N/A SER 85.A OG THR 18.A OG1 no hydrogen 2.358 N/A VAL 94.A N VAL 84.A O no hydrogen 2.873 N/A ARG 95.A N GLN 142.A OE1 no hydrogen 2.906 N/A ARG 95.A NH1 THR 58.A O no hydrogen 3.138 N/A ARG 95.A NH1 THR 81.A OG1 no hydrogen 2.592 N/A ARG 95.A NH2 THR 58.A O no hydrogen 2.668 N/A ALA 96.A N ASP 82.A O no hydrogen 2.976 N/A ILE 98.A N GLY 80.A O no hydrogen 2.884 N/A ALA 99.A N PHE 37.A O no hydrogen 2.779 N/A ALA 100.A N GLU 78.A O no hydrogen 2.869 N/A ILE 101.A N VAL 39.A O no hydrogen 2.856 N/A THR 102.A N GLU 76.A O no hydrogen 3.029 N/A GLU 103.A N GLU 76.A O no hydrogen 3.474 N/A ASP 105.A N LYS 74.A O no hydrogen 2.932 N/A SER 112.A OG ILE 109.A O no hydrogen 2.771 N/A TRP 114.A NE1 GLN 11.A O no hydrogen 2.833 N/A GLU 115.A N ASN 27.A O no hydrogen 2.915 N/A ILE 117.A N ALA 38.A O no hydrogen 2.766 N/A LEU 118.A N LEU 29.A O no hydrogen 2.769 N/A GLY 119.A N ASN 36.A O no hydrogen 2.818 N/A LEU 120.A N ASP 31.A O no hydrogen 2.800 N/A ALA 121.A N SER 34.A O no hydrogen 2.957 N/A TYR 122.A N TRP 181.A O no hydrogen 2.967 N/A ILE 125.A N TYR 122.A O no hydrogen 3.382 N/A ALA 126.A N ALA 123.A O no hydrogen 2.934 N/A ARG 127.A N ASN 36.A OD1 no hydrogen 2.778 N/A ARG 127.A NH2 ILE 125.A O no hydrogen 2.738 N/A SER 131.A N ASP 129.A OD2 no hydrogen 2.668 N/A SER 131.A OG ASP 129.A OD2 no hydrogen 2.353 N/A LEU 132.A N ASP 129.A O no hydrogen 3.263 N/A SER 138.A N PRO 134.A O no hydrogen 3.221 N/A SER 138.A OG GLU 133.A OE2 no hydrogen 2.654 N/A SER 138.A OG PRO 134.A O no hydrogen 3.406 N/A LEU 139.A N PHE 135.A O no hydrogen 2.829 N/A VAL 140.A N PHE 136.A O no hydrogen 2.996 N/A LYS 141.A N ASP 137.A O no hydrogen 2.938 N/A GLN 142.A N SER 138.A O no hydrogen 3.035 N/A GLN 142.A NE2 ARG 95.A O no hydrogen 2.863 N/A THR 143.A N LEU 139.A O no hydrogen 3.180 N/A THR 143.A OG1 LEU 139.A O no hydrogen 2.626 N/A VAL 145.A N THR 143.A OG1 no hydrogen 3.279 N/A LEU 148.A N PRO 146.A O no hydrogen 2.920 N/A PHE 149.A N PHE 325.A O no hydrogen 3.281 N/A SER 150.A N ILE 159.A O no hydrogen 2.827 N/A SER 150.A OG TYR 322.A OH no hydrogen 3.034 N/A LEU 151.A N VAL 323.A O no hydrogen 2.807 N/A GLN 152.A N SER 157.A O no hydrogen 2.740 N/A GLN 152.A NE2 SER 337.A OG no hydrogen 3.341 N/A SER 157.A N GLN 152.A O no hydrogen 2.757 N/A SER 157.A OG GLN 152.A OE1 no hydrogen 3.283 N/A MET 158.A N ASN 4.A OD1 no hydrogen 2.732 N/A ILE 159.A N SER 150.A O no hydrogen 3.027 N/A GLY 161.A N LEU 148.A O no hydrogen 2.726 N/A ASP 164.A N TYR 322.A OH no hydrogen 3.047 N/A HIS 165.A ND1 TYR 168.A OH no hydrogen 2.590 N/A SER 166.A N ASP 164.A OD2 no hydrogen 2.855 N/A SER 166.A OG ASP 164.A OD2 no hydrogen 2.727 N/A LEU 167.A N ASP 164.A O no hydrogen 3.128 N/A TYR 168.A OH HIS 165.A ND1 no hydrogen 2.590 N/A THR 169.A N VAL 336.A O no hydrogen 3.140 N/A TRP 173.A N PHE 334.A O no hydrogen 2.955 N/A THR 175.A N ILE 332.A O no hydrogen 2.875 N/A THR 175.A OG1 MET 272.A O no hydrogen 2.630 N/A ILE 177.A N LYS 330.A O no hydrogen 2.774 N/A ARG 178.A N GLU 184.A O no hydrogen 2.773 N/A ARG 178.A NH1 GLU 184.A OE2 no hydrogen 2.876 N/A ARG 178.A NH1 TYR 360.A O no hydrogen 3.042 N/A ARG 178.A NH2 TYR 360.A O no hydrogen 3.218 N/A ARG 179.A NE GLU 124.A OE1 no hydrogen 3.527 N/A ARG 179.A NH1 GLU 124.A OE2 no hydrogen 2.021 N/A TRP 181.A N ARG 179.A O no hydrogen 3.171 N/A TRP 181.A N TYR 182.A O no hydrogen 3.082 N/A TRP 181.A NE1 GLU 184.A OE1 no hydrogen 2.836 N/A TYR 183.A OH LEU 120.A O no hydrogen 2.575 N/A VAL 185.A N SER 209.A O no hydrogen 2.784 N/A ILE 187.A N ASN 205.A OD1 no hydrogen 2.704 N/A VAL 188.A N TYR 270.A O no hydrogen 2.768 N/A ARG 189.A NE GLU 191.A OE2 no hydrogen 2.847 N/A ARG 189.A NH2 GLU 191.A OE2 no hydrogen 2.748 N/A GLU 191.A N SER 268.A O no hydrogen 3.053 N/A ILE 192.A N GLN 195.A O no hydrogen 2.852 N/A ASN 193.A N VAL 266.A O no hydrogen 3.021 N/A GLN 195.A N ILE 192.A O no hydrogen 2.948 N/A LEU 197.A N VAL 190.A O no hydrogen 2.977 N/A LYS 198.A N ASP 196.A OD1 no hydrogen 2.992 N/A MET 199.A N TYR 204.A OH no hydrogen 3.362 N/A CYS 201.A SG GLU 356.A OE2 no hydrogen 3.697 N/A LYS 202.A N ASP 200.A OD1 no hydrogen 3.222 N/A LYS 202.A NZ ASP 357.A O no hydrogen 2.590 N/A LYS 202.A NZ GLY 359.A O no hydrogen 2.834 N/A GLU 203.A N ASP 200.A O no hydrogen 2.974 N/A TYR 204.A N CYS 201.A O no hydrogen 3.131 N/A ASN 205.A N LYS 202.A O no hydrogen 3.059 N/A ASN 205.A ND2 ILE 187.A O no hydrogen 2.970 N/A ASN 205.A ND2 CYS 358.A O no hydrogen 2.853 N/A LYS 208.A NZ ASP 207.A OD2 no hydrogen 3.381 N/A LYS 208.A NZ THR 309.A O no hydrogen 2.939 N/A SER 209.A OG ASN 205.A OD1 no hydrogen 2.896 N/A ILE 210.A N THR 311.A O no hydrogen 3.036 N/A VAL 211.A N TYR 183.A O no hydrogen 3.043 N/A ASP 212.A N MET 313.A O no hydrogen 3.100 N/A SER 213.A N THR 32.A OG1 no hydrogen 2.920 N/A SER 213.A OG VAL 30.A O no hydrogen 2.808 N/A GLY 214.A N ASP 212.A OD1 no hydrogen 2.875 N/A THR 215.A N ASP 212.A O no hydrogen 3.191 N/A THR 215.A OG1 ASP 212.A OD2 no hydrogen 2.580 N/A THR 216.A OG1 SER 9.A O no hydrogen 2.936 N/A ASN 217.A ND2 SER 305.A OG no hydrogen 3.305 N/A LEU 218.A N ALA 303.A O no hydrogen 3.031 N/A ARG 219.A N VAL 312.A O no hydrogen 2.910 N/A LEU 220.A N SER 305.A O no hydrogen 2.996 N/A PHE 225.A N PRO 221.A O no hydrogen 2.737 N/A GLU 226.A N LYS 222.A O no hydrogen 2.997 N/A ALA 227.A N LYS 223.A O no hydrogen 3.098 N/A ALA 228.A N VAL 224.A O no hydrogen 2.874 N/A VAL 229.A N PHE 225.A O no hydrogen 2.856 N/A LYS 230.A N GLU 226.A O no hydrogen 2.973 N/A SER 231.A N ALA 227.A O no hydrogen 3.109 N/A ILE 232.A N ALA 228.A O no hydrogen 2.886 N/A LYS 233.A N VAL 229.A O no hydrogen 2.760 N/A ALA 234.A N LYS 230.A O no hydrogen 3.019 N/A ALA 235.A N SER 231.A O no hydrogen 3.112 N/A SER 236.A N ILE 232.A O no hydrogen 3.015 N/A SER 236.A N LYS 233.A O no hydrogen 2.757 N/A SER 236.A OG ILE 232.A O no hydrogen 2.868 N/A SER 236.A OG LYS 233.A O no hydrogen 3.258 N/A SER 237.A OG ALA 234.A O no hydrogen 3.317 N/A GLU 239.A N SER 236.A O no hydrogen 2.891 N/A PHE 245.A N PRO 242.A O no hydrogen 3.046 N/A LEU 247.A N ASP 243.A O no hydrogen 3.108 N/A GLY 248.A N PHE 245.A O no hydrogen 3.006 N/A GLU 249.A N GLY 244.A O no hydrogen 2.811 N/A VAL 252.A N TYR 300.A O no hydrogen 3.039 N/A TRP 254.A N ASP 298.A O no hydrogen 2.927 N/A TRP 254.A NE1 GLU 239.A OE2 no hydrogen 2.995 N/A GLY 257.A N ASP 298.A OD2 no hydrogen 2.451 N/A THR 258.A N GLN 255.A O no hydrogen 2.890 N/A THR 258.A OG1 GLN 255.A O no hydrogen 2.843 N/A THR 259.A OG1 TYR 300.A OH no hydrogen 3.198 N/A TRP 261.A N THR 259.A O no hydrogen 2.943 N/A ILE 263.A N PRO 260.A O no hydrogen 3.001 N/A PHE 264.A N TRP 261.A O no hydrogen 2.876 N/A VAL 266.A N ASN 193.A OD1 no hydrogen 3.104 N/A ILE 267.A N ILE 284.A O no hydrogen 2.935 N/A SER 268.A N GLU 191.A O no hydrogen 2.907 N/A SER 268.A OG THR 283.A OG1 no hydrogen 2.600 N/A LEU 269.A N ILE 282.A O no hydrogen 2.901 N/A TYR 270.A N ARG 189.A O no hydrogen 2.909 N/A TYR 270.A OH GLU 191.A OE1 no hydrogen 2.905 N/A TYR 270.A OH GLU 191.A OE2 no hydrogen 2.972 N/A LEU 271.A N PHE 280.A O no hydrogen 2.784 N/A MET 272.A N ILE 186.A O no hydrogen 3.014 N/A GLY 273.A N GLN 278.A O no hydrogen 2.708 N/A GLN 278.A N VAL 275.A O no hydrogen 3.040 N/A SER 279.A N PHE 350.A O no hydrogen 2.837 N/A PHE 280.A N LEU 271.A O no hydrogen 3.071 N/A ARG 281.A N GLU 347.A O no hydrogen 2.814 N/A ARG 281.A NE GLU 347.A OE2 no hydrogen 2.981 N/A ARG 281.A NH1 TYR 270.A OH no hydrogen 2.749 N/A ARG 281.A NH2 GLU 347.A OE2 no hydrogen 2.955 N/A ILE 282.A N LEU 269.A O no hydrogen 2.839 N/A THR 283.A N ALA 345.A O no hydrogen 2.925 N/A THR 283.A OG1 SER 268.A OG no hydrogen 2.600 N/A ILE 284.A N ILE 267.A O no hydrogen 2.591 N/A LEU 285.A N GLN 288.A OE1 no hydrogen 3.130 N/A GLN 287.A N GLN 287.A OE1 no hydrogen 2.913 N/A GLN 288.A N LEU 285.A O no hydrogen 2.904 N/A GLN 288.A NE2 VAL 316.A O no hydrogen 3.095 N/A TYR 289.A N LEU 285.A O no hydrogen 3.439 N/A TYR 289.A OH PRO 265.A O no hydrogen 2.484 N/A LEU 290.A N PRO 286.A O no hydrogen 2.802 N/A ARG 291.A N LYS 301.A O no hydrogen 2.913 N/A ARG 291.A NE SER 9.A OG no hydrogen 3.020 N/A ARG 291.A NH1 GLN 288.A O no hydrogen 2.886 N/A VAL 293.A N CYS 299.A O no hydrogen 3.187 N/A GLN 296.A N GLN 296.A OE1 no hydrogen 2.815 N/A ASP 298.A N TRP 254.A O no hydrogen 2.885 N/A TYR 300.A N VAL 252.A O no hydrogen 2.874 N/A TYR 300.A OH THR 259.A OG1 no hydrogen 3.198 N/A LYS 301.A N ARG 291.A O no hydrogen 2.850 N/A ALA 303.A N TYR 289.A O no hydrogen 2.770 N/A SER 305.A N LEU 218.A O no hydrogen 3.049 N/A SER 307.A N LEU 220.A O no hydrogen 2.756 N/A SER 307.A OG GLY 310.A O no hydrogen 2.545 N/A THR 309.A N SER 307.A OG no hydrogen 3.039 N/A THR 311.A N LYS 208.A O no hydrogen 2.895 N/A THR 311.A OG1 TYR 204.A O no hydrogen 2.739 N/A VAL 312.A N ARG 219.A O no hydrogen 2.838 N/A MET 313.A N ILE 210.A O no hydrogen 2.852 N/A ALA 315.A N THR 215.A O no hydrogen 2.687 N/A VAL 316.A N THR 216.A O no hydrogen 2.977 N/A ILE 317.A N GLY 314.A O no hydrogen 3.084 N/A MET 318.A N GLY 314.A O no hydrogen 3.061 N/A GLU 319.A N ALA 315.A O no hydrogen 2.944 N/A PHE 321.A N MET 318.A O no hydrogen 2.997 N/A TYR 322.A N ALA 335.A O no hydrogen 2.840 N/A TYR 322.A OH SER 150.A OG no hydrogen 3.034 N/A VAL 323.A N LEU 151.A O no hydrogen 3.045 N/A VAL 324.A N GLY 333.A O no hydrogen 2.837 N/A PHE 325.A N PHE 149.A O no hydrogen 2.740 N/A ASP 326.A N ARG 331.A O no hydrogen 2.922 N/A ARG 327.A N PHE 325.A O no hydrogen 3.018 N/A ARG 327.A NE ASN 147.A OD1 no hydrogen 3.053 N/A ARG 327.A NH1 TYR 183.A OH no hydrogen 3.031 N/A ARG 327.A NH2 ASP 137.A OD2 no hydrogen 2.936 N/A ALA 328.A N ASN 147.A O no hydrogen 3.061 N/A ARG 329.A N ASP 326.A OD1 no hydrogen 3.160 N/A LYS 330.A N ARG 327.A O no hydrogen 3.085 N/A ARG 331.A N ASP 326.A O no hydrogen 3.122 N/A ARG 331.A NE ASP 326.A OD2 no hydrogen 2.887 N/A ARG 331.A NH1 GLU 274.A OE2 no hydrogen 2.983 N/A ARG 331.A NH2 ASP 326.A OD2 no hydrogen 3.260 N/A ILE 332.A N THR 175.A O no hydrogen 2.816 N/A GLY 333.A N VAL 324.A O no hydrogen 2.785 N/A PHE 334.A N TRP 173.A O no hydrogen 2.816 N/A ALA 335.A N TYR 322.A O no hydrogen 3.069 N/A SER 337.A N GLY 320.A O no hydrogen 3.335 N/A ALA 338.A N LEU 167.A O no hydrogen 3.050 N/A CYS 339.A SG SER 337.A OG no hydrogen 3.338 N/A ARG 342.A NH1 PHE 264.A O no hydrogen 3.091 N/A ARG 342.A NH2 TRP 261.A O no hydrogen 3.193 N/A ALA 345.A N THR 283.A O no hydrogen 3.444 N/A GLU 347.A N ARG 281.A O no hydrogen 3.051 N/A PHE 350.A N SER 279.A O no hydrogen 2.856 N/A THR 352.A N ASN 277.A O no hydrogen 2.684 N/A CYS 358.A SG GLU 356.A O no hydrogen 3.947 N/A GLY 359.A N ASP 357.A OD1 no hydrogen 3.124 N/A THR 365.A OG1 SER 368.A OG no hydrogen 2.631 N/A SER 368.A N THR 365.A OG1 no hydrogen 2.961 N/A SER 368.A OG THR 365.A OG1 no hydrogen 2.631 N/A ARG 369.A N THR 365.A O no hydrogen 3.141 N/A ARG 369.A NH1 GLN 364.A O no hydrogen 3.038 N/A ARG 369.A NH1 GLN 364.A OE1 no hydrogen 2.870 N/A ARG 369.A NH2 ASP 366.A OD1 no hydrogen 3.058 N/A SER 370.A N ASP 366.A O no hydrogen 2.707 N/A SER 370.A OG GLU 367.A O no hydrogen 2.565 N/A HIS 371.A NE2 GLU 367.A OE2 no hydrogen 3.301 N/A