Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4i1c_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 5.A N PHE 1.A O no hydrogen 3.389 N/A ASP 6.A N SER 160.A OG no hydrogen 2.889 N/A ASN 7.A N MET 4.A O no hydrogen 3.323 N/A ASN 7.A ND2 MET 161.A O no hydrogen 2.867 N/A LEU 8.A N GLY 159.A O no hydrogen 2.983 N/A ARG 9.A N TYR 17.A O no hydrogen 3.138 N/A LYS 11.A N GLY 15.A O no hydrogen 3.077 N/A GLN 14.A N LYS 11.A O no hydrogen 3.289 N/A GLY 15.A N LYS 11.A O no hydrogen 2.579 N/A TYR 16.A OH CYS 157.A O no hydrogen 2.553 N/A TYR 16.A OH GLU 326.A OE1 no hydrogen 2.650 N/A TYR 17.A N ARG 9.A O no hydrogen 2.903 N/A VAL 18.A N ILE 31.A O no hydrogen 2.726 N/A MET 20.A N LEU 29.A O no hydrogen 3.018 N/A THR 21.A N SER 88.A O no hydrogen 2.933 N/A THR 21.A OG1 THR 28.A OG1 no hydrogen 2.874 N/A VAL 22.A N GLN 27.A O no hydrogen 2.745 N/A GLY 23.A N LEU 86.A O no hydrogen 2.801 N/A SER 24.A N THR 61.A OG1 no hydrogen 2.974 N/A GLN 27.A N VAL 22.A O no hydrogen 2.958 N/A GLN 27.A NE2 GLN 55.A O no hydrogen 2.813 N/A THR 28.A OG1 THR 21.A OG1 no hydrogen 2.874 N/A LEU 29.A N MET 20.A O no hydrogen 2.859 N/A ASN 30.A N GLU 118.A OE2 no hydrogen 2.673 N/A ASN 30.A ND2 ASN 116.A O no hydrogen 3.309 N/A ILE 31.A N VAL 18.A O no hydrogen 2.868 N/A LEU 32.A N GLY 119.A O no hydrogen 2.770 N/A VAL 33.A N TYR 16.A O no hydrogen 2.804 N/A ASP 34.A N LEU 121.A O no hydrogen 2.923 N/A THR 35.A N SER 216.A OG no hydrogen 2.890 N/A THR 35.A OG1 VAL 214.A O no hydrogen 2.777 N/A GLY 36.A N ASP 34.A OD2 no hydrogen 3.013 N/A SER 37.A OG ASP 34.A OD1 no hydrogen 2.308 N/A SER 38.A OG TYR 125.A O no hydrogen 2.539 N/A ASN 39.A ND2 ARG 130.A O no hydrogen 2.776 N/A ALA 41.A N ILE 120.A O no hydrogen 3.060 N/A VAL 42.A N ALA 102.A O no hydrogen 2.848 N/A GLY 43.A N GLU 118.A O no hydrogen 2.720 N/A ALA 44.A N ILE 104.A O no hydrogen 2.880 N/A PHE 49.A N HIS 47.A ND1 no hydrogen 2.864 N/A LEU 50.A N HIS 47.A O no hydrogen 3.190 N/A ARG 52.A NE GLU 118.A OE2 no hydrogen 2.897 N/A ARG 52.A NH2 GLU 118.A OE1 no hydrogen 2.928 N/A ARG 52.A NH2 GLU 118.A OE2 no hydrogen 3.504 N/A TYR 54.A N GLY 43.A O no hydrogen 2.761 N/A TYR 54.A OH ASP 85.A OD2 no hydrogen 2.539 N/A GLN 55.A N GLN 27.A OE1 no hydrogen 2.632 N/A GLN 57.A N GLN 57.A OE1 no hydrogen 2.777 N/A LEU 58.A N GLN 55.A O no hydrogen 3.186 N/A SER 59.A N ARG 56.A O no hydrogen 3.081 N/A SER 59.A OG ASP 85.A OD1 no hydrogen 3.366 N/A SER 59.A OG ASP 85.A OD2 no hydrogen 2.585 N/A SER 60.A N SER 24.A O no hydrogen 2.778 N/A SER 60.A OG SER 24.A O no hydrogen 2.806 N/A THR 61.A OG1 ASP 85.A OD1 no hydrogen 2.707 N/A TYR 62.A N SER 59.A OG no hydrogen 3.121 N/A ARG 63.A N THR 84.A O no hydrogen 2.957 N/A LEU 65.A N LEU 82.A O no hydrogen 2.875 N/A ARG 66.A N ASP 64.A OD1 no hydrogen 2.528 N/A VAL 69.A N GLY 80.A O no hydrogen 2.922 N/A VAL 71.A N TRP 78.A O no hydrogen 2.647 N/A TYR 73.A N GLY 76.A O no hydrogen 2.920 N/A GLY 76.A N TYR 73.A O no hydrogen 3.400 N/A LYS 77.A N ASP 108.A O no hydrogen 2.962 N/A LYS 77.A NZ GLU 79.A OE1 no hydrogen 2.751 N/A LYS 77.A NZ GLU 106.A OE1 no hydrogen 2.618 N/A TRP 78.A N VAL 71.A O no hydrogen 2.886 N/A GLU 79.A N GLU 106.A O no hydrogen 2.938 N/A GLY 80.A N VAL 69.A O no hydrogen 3.143 N/A GLU 81.A N ALA 103.A O no hydrogen 3.135 N/A LEU 82.A N LYS 67.A O no hydrogen 2.663 N/A THR 84.A N ARG 63.A O no hydrogen 2.982 N/A ASP 85.A N ALA 99.A O no hydrogen 3.030 N/A LEU 86.A N ASP 85.A OD1 no hydrogen 2.861 N/A VAL 87.A N VAL 97.A O no hydrogen 2.746 N/A SER 88.A N THR 21.A O no hydrogen 2.952 N/A GLY 92.A N ILE 89.A O no hydrogen 2.726 N/A VAL 95.A N PRO 93.A O no hydrogen 2.823 N/A VAL 97.A N VAL 87.A O no hydrogen 2.847 N/A ARG 98.A N GLN 145.A OE1 no hydrogen 2.773 N/A ARG 98.A NH1 THR 61.A O no hydrogen 3.137 N/A ARG 98.A NH1 THR 84.A OG1 no hydrogen 2.754 N/A ARG 98.A NH2 THR 61.A O no hydrogen 2.939 N/A ALA 99.A N ASP 85.A O no hydrogen 2.927 N/A ILE 101.A N GLY 83.A O no hydrogen 2.975 N/A ALA 102.A N PHE 40.A O no hydrogen 2.827 N/A ALA 103.A N GLU 81.A O no hydrogen 2.969 N/A ILE 104.A N VAL 42.A O no hydrogen 2.773 N/A THR 105.A N GLU 79.A O no hydrogen 2.895 N/A GLU 106.A N GLU 79.A O no hydrogen 3.475 N/A ASP 108.A N LYS 77.A O no hydrogen 2.817 N/A LYS 109.A NZ ASP 108.A OD2 no hydrogen 3.170 N/A SER 115.A OG ILE 112.A O no hydrogen 2.795 N/A TRP 117.A NE1 GLN 14.A O no hydrogen 2.786 N/A GLU 118.A N ASN 30.A O no hydrogen 2.645 N/A ILE 120.A N ALA 41.A O no hydrogen 2.799 N/A LEU 121.A N LEU 32.A O no hydrogen 2.739 N/A GLY 122.A N ASN 39.A O no hydrogen 2.925 N/A LEU 123.A N ASP 34.A O no hydrogen 2.809 N/A ALA 124.A N SER 37.A O no hydrogen 2.706 N/A TYR 125.A N TRP 184.A O no hydrogen 2.989 N/A ILE 128.A N TYR 125.A O no hydrogen 3.172 N/A ALA 129.A N ALA 126.A O no hydrogen 3.134 N/A ARG 130.A N ASN 39.A OD1 no hydrogen 2.869 N/A SER 134.A N ASP 132.A OD2 no hydrogen 2.744 N/A SER 134.A OG ASP 132.A OD2 no hydrogen 2.314 N/A LEU 135.A N ASP 132.A O no hydrogen 3.386 N/A SER 141.A N PRO 137.A O no hydrogen 3.077 N/A SER 141.A OG GLU 136.A OE2 no hydrogen 2.481 N/A SER 141.A OG PRO 137.A O no hydrogen 3.383 N/A LEU 142.A N PHE 138.A O no hydrogen 2.919 N/A VAL 143.A N PHE 139.A O no hydrogen 3.087 N/A LYS 144.A N ASP 140.A O no hydrogen 3.008 N/A LYS 144.A NZ GLU 136.A OE1 no hydrogen 2.764 N/A GLN 145.A N SER 141.A O no hydrogen 2.830 N/A GLN 145.A NE2 ARG 98.A O no hydrogen 2.773 N/A THR 146.A N VAL 143.A O no hydrogen 3.297 N/A THR 146.A OG1 LEU 142.A O no hydrogen 2.687 N/A HIS 147.A N VAL 143.A O no hydrogen 3.172 N/A VAL 148.A N THR 146.A OG1 no hydrogen 3.169 N/A LEU 151.A N PRO 149.A O no hydrogen 2.975 N/A PHE 152.A N PHE 332.A O no hydrogen 3.301 N/A SER 153.A N ILE 162.A O no hydrogen 2.817 N/A SER 153.A OG TYR 329.A OH no hydrogen 2.821 N/A LEU 154.A N VAL 330.A O no hydrogen 2.742 N/A GLN 155.A N SER 160.A O no hydrogen 2.867 N/A SER 160.A N GLN 155.A O no hydrogen 2.966 N/A SER 160.A OG GLN 155.A OE1 no hydrogen 3.305 N/A MET 161.A N ASN 7.A OD1 no hydrogen 2.991 N/A ILE 162.A N SER 153.A O no hydrogen 2.899 N/A GLY 164.A N LEU 151.A O no hydrogen 2.846 N/A ASP 167.A N TYR 329.A OH no hydrogen 2.997 N/A SER 169.A N ASP 167.A OD2 no hydrogen 2.854 N/A SER 169.A OG ASP 167.A OD2 no hydrogen 2.633 N/A LEU 170.A N ASP 167.A O no hydrogen 3.130 N/A TYR 171.A OH HIS 168.A ND1 no hydrogen 2.755 N/A THR 172.A N VAL 343.A O no hydrogen 3.284 N/A TRP 176.A N PHE 341.A O no hydrogen 3.052 N/A THR 178.A N ILE 339.A O no hydrogen 2.829 N/A THR 178.A OG1 MET 275.A O no hydrogen 2.577 N/A ILE 180.A N LYS 337.A O no hydrogen 2.699 N/A ARG 181.A N GLU 187.A O no hydrogen 2.873 N/A ARG 181.A NH1 GLU 187.A OE2 no hydrogen 3.050 N/A ARG 181.A NH1 TYR 365.A O no hydrogen 2.774 N/A ARG 181.A NH2 TYR 365.A O no hydrogen 3.293 N/A TRP 184.A N ARG 182.A O no hydrogen 3.138 N/A TRP 184.A N TYR 185.A O no hydrogen 3.099 N/A TRP 184.A NE1 GLU 187.A OE1 no hydrogen 2.752 N/A TYR 186.A OH LEU 123.A O no hydrogen 2.645 N/A VAL 188.A N SER 212.A O no hydrogen 2.647 N/A ILE 190.A N ASN 208.A OD1 no hydrogen 2.927 N/A VAL 191.A N TYR 273.A O no hydrogen 2.641 N/A ARG 192.A NE GLU 194.A OE2 no hydrogen 2.610 N/A ARG 192.A NH2 GLU 194.A OE2 no hydrogen 2.148 N/A GLU 194.A N SER 271.A O no hydrogen 3.025 N/A ILE 195.A N GLN 198.A O no hydrogen 2.821 N/A ASN 196.A N VAL 269.A O no hydrogen 2.912 N/A GLN 198.A N ILE 195.A O no hydrogen 2.999 N/A GLN 198.A NE2 ASN 196.A O no hydrogen 3.689 N/A LEU 200.A N VAL 193.A O no hydrogen 2.990 N/A LYS 201.A N ASP 199.A OD1 no hydrogen 3.083 N/A MET 202.A N TYR 207.A OH no hydrogen 3.384 N/A LYS 205.A N ASP 203.A OD1 no hydrogen 3.201 N/A LYS 205.A NZ ASP 362.A O no hydrogen 2.627 N/A LYS 205.A NZ GLY 364.A O no hydrogen 2.835 N/A GLU 206.A N ASP 203.A O no hydrogen 2.705 N/A TYR 207.A N CYS 204.A O no hydrogen 3.000 N/A ASN 208.A N LYS 205.A O no hydrogen 3.068 N/A ASN 208.A ND2 ILE 190.A O no hydrogen 2.976 N/A ASN 208.A ND2 CYS 363.A O no hydrogen 2.772 N/A LYS 211.A NZ ASP 210.A OD2 no hydrogen 3.467 N/A LYS 211.A NZ THR 316.A O no hydrogen 3.014 N/A SER 212.A OG ASN 208.A OD1 no hydrogen 2.761 N/A ILE 213.A N THR 318.A O no hydrogen 3.081 N/A VAL 214.A N TYR 186.A O no hydrogen 3.054 N/A ASP 215.A N MET 320.A O no hydrogen 3.088 N/A SER 216.A N THR 35.A OG1 no hydrogen 3.028 N/A SER 216.A OG VAL 33.A O no hydrogen 2.970 N/A GLY 217.A N ASP 215.A OD1 no hydrogen 2.823 N/A THR 218.A N ASP 215.A O no hydrogen 3.200 N/A THR 218.A OG1 ASP 215.A OD2 no hydrogen 2.674 N/A THR 219.A OG1 SER 12.A O no hydrogen 2.686 N/A ASN 220.A ND2 SER 312.A OG no hydrogen 2.818 N/A LEU 221.A N ALA 310.A O no hydrogen 3.147 N/A ARG 222.A N VAL 319.A O no hydrogen 2.900 N/A ARG 222.A NH1 GLN 313.A O no hydrogen 2.889 N/A LEU 223.A N SER 312.A O no hydrogen 3.110 N/A PHE 228.A N PRO 224.A O no hydrogen 2.876 N/A GLU 229.A N LYS 225.A O no hydrogen 3.091 N/A ALA 230.A N LYS 226.A O no hydrogen 3.110 N/A ALA 231.A N VAL 227.A O no hydrogen 2.928 N/A VAL 232.A N PHE 228.A O no hydrogen 2.762 N/A LYS 233.A N GLU 229.A O no hydrogen 2.985 N/A SER 234.A N ALA 230.A O no hydrogen 3.087 N/A ILE 235.A N ALA 231.A O no hydrogen 2.711 N/A LYS 236.A N VAL 232.A O no hydrogen 2.876 N/A ALA 237.A N LYS 233.A O no hydrogen 3.018 N/A ALA 238.A N SER 234.A O no hydrogen 3.197 N/A SER 239.A N LYS 236.A O no hydrogen 3.288 N/A SER 239.A OG ILE 235.A O no hydrogen 3.450 N/A SER 240.A N ALA 237.A O no hydrogen 3.384 N/A SER 240.A OG ALA 237.A O no hydrogen 3.159 N/A GLU 242.A N SER 239.A O no hydrogen 2.973 N/A PHE 248.A N PRO 245.A O no hydrogen 2.991 N/A LEU 250.A N ASP 246.A O no hydrogen 2.942 N/A GLY 251.A N PHE 248.A O no hydrogen 3.054 N/A GLU 252.A N GLY 247.A O no hydrogen 2.690 N/A VAL 255.A N TYR 307.A O no hydrogen 3.192 N/A TRP 257.A N ASP 305.A O no hydrogen 2.978 N/A TRP 257.A NE1 GLU 242.A OE2 no hydrogen 2.606 N/A ALA 259.A N GLN 303.A O no hydrogen 3.115 N/A GLY 260.A N ASP 305.A OD2 no hydrogen 2.829 N/A THR 261.A N GLN 258.A O no hydrogen 2.776 N/A THR 261.A OG1 GLN 258.A O no hydrogen 3.105 N/A THR 262.A OG1 TYR 307.A OH no hydrogen 3.316 N/A ILE 266.A N PRO 263.A O no hydrogen 2.954 N/A PHE 267.A N TRP 264.A O no hydrogen 2.556 N/A ILE 270.A N ILE 287.A O no hydrogen 3.085 N/A SER 271.A N GLU 194.A O no hydrogen 2.977 N/A SER 271.A OG THR 286.A OG1 no hydrogen 2.625 N/A LEU 272.A N ILE 285.A O no hydrogen 3.012 N/A TYR 273.A N ARG 192.A O no hydrogen 2.888 N/A TYR 273.A OH GLU 194.A OE1 no hydrogen 3.086 N/A TYR 273.A OH GLU 194.A OE2 no hydrogen 2.796 N/A LEU 274.A N PHE 283.A O no hydrogen 2.664 N/A MET 275.A N ILE 189.A O no hydrogen 2.782 N/A GLY 276.A N GLN 281.A O no hydrogen 2.797 N/A GLN 281.A N VAL 278.A O no hydrogen 2.946 N/A SER 282.A N PHE 355.A O no hydrogen 2.713 N/A PHE 283.A N LEU 274.A O no hydrogen 3.014 N/A ARG 284.A N GLU 352.A O no hydrogen 2.866 N/A ARG 284.A NE GLU 352.A OE1 no hydrogen 2.981 N/A ARG 284.A NH1 GLU 352.A OE1 no hydrogen 3.040 N/A ARG 284.A NH2 TYR 273.A OH no hydrogen 2.904 N/A ILE 285.A N LEU 272.A O no hydrogen 2.811 N/A THR 286.A N ALA 350.A O no hydrogen 2.796 N/A THR 286.A OG1 SER 271.A OG no hydrogen 2.625 N/A ILE 287.A N ILE 270.A O no hydrogen 2.584 N/A LEU 288.A N GLN 291.A OE1 no hydrogen 3.097 N/A GLN 290.A N GLN 290.A OE1 no hydrogen 2.890 N/A GLN 291.A N LEU 288.A O no hydrogen 2.708 N/A GLN 291.A NE2 VAL 323.A O no hydrogen 3.396 N/A TYR 292.A N LEU 288.A O no hydrogen 3.227 N/A TYR 292.A OH PRO 268.A O no hydrogen 2.661 N/A LEU 293.A N PRO 289.A O no hydrogen 2.659 N/A ARG 294.A N LYS 308.A O no hydrogen 2.799 N/A ARG 294.A NE GLN 291.A O no hydrogen 3.059 N/A ARG 294.A NH2 GLN 291.A O no hydrogen 3.453 N/A VAL 296.A N CYS 306.A O no hydrogen 3.011 N/A ASP 305.A N TRP 257.A O no hydrogen 2.963 N/A TYR 307.A N VAL 255.A O no hydrogen 2.828 N/A TYR 307.A OH THR 262.A OG1 no hydrogen 3.316 N/A LYS 308.A N ARG 294.A O no hydrogen 2.621 N/A LYS 308.A NZ GLY 251.A O no hydrogen 2.966 N/A ALA 310.A N TYR 292.A O no hydrogen 2.649 N/A SER 312.A N LEU 221.A O no hydrogen 3.145 N/A SER 314.A OG GLY 317.A O no hydrogen 2.571 N/A THR 316.A N SER 314.A OG no hydrogen 2.976 N/A THR 318.A N LYS 211.A O no hydrogen 2.948 N/A THR 318.A OG1 TYR 207.A O no hydrogen 2.705 N/A VAL 319.A N ARG 222.A O no hydrogen 2.947 N/A MET 320.A N ILE 213.A O no hydrogen 2.906 N/A ALA 322.A N THR 218.A O no hydrogen 2.832 N/A VAL 323.A N THR 219.A O no hydrogen 2.898 N/A ILE 324.A N GLY 321.A O no hydrogen 3.150 N/A MET 325.A N GLY 321.A O no hydrogen 3.097 N/A GLU 326.A N ALA 322.A O no hydrogen 3.044 N/A PHE 328.A N MET 325.A O no hydrogen 2.916 N/A TYR 329.A N ALA 342.A O no hydrogen 2.791 N/A TYR 329.A OH SER 153.A OG no hydrogen 2.821 N/A VAL 330.A N LEU 154.A O no hydrogen 3.036 N/A VAL 331.A N GLY 340.A O no hydrogen 2.729 N/A PHE 332.A N PHE 152.A O no hydrogen 2.853 N/A ASP 333.A N ARG 338.A O no hydrogen 2.762 N/A ARG 334.A N PHE 332.A O no hydrogen 2.968 N/A ARG 334.A NE ASN 150.A OD1 no hydrogen 2.993 N/A ARG 334.A NH1 TYR 186.A OH no hydrogen 2.986 N/A ARG 334.A NH2 ASP 140.A OD2 no hydrogen 2.898 N/A ALA 335.A N ASN 150.A O no hydrogen 3.022 N/A ARG 336.A N ASP 333.A O no hydrogen 3.107 N/A ARG 336.A NH1 ASP 333.A OD1 no hydrogen 2.733 N/A ARG 336.A NH1 ASP 333.A OD2 no hydrogen 3.125 N/A LYS 337.A N ARG 334.A O no hydrogen 3.110 N/A ARG 338.A N ASP 333.A O no hydrogen 3.156 N/A ARG 338.A NE ASP 333.A OD2 no hydrogen 2.958 N/A ARG 338.A NH1 GLU 277.A OE2 no hydrogen 2.832 N/A ARG 338.A NH2 ASP 333.A OD2 no hydrogen 3.091 N/A ILE 339.A N THR 178.A O no hydrogen 2.894 N/A GLY 340.A N VAL 331.A O no hydrogen 2.611 N/A PHE 341.A N TRP 176.A O no hydrogen 2.815 N/A ALA 342.A N TYR 329.A O no hydrogen 2.932 N/A SER 344.A N GLY 327.A O no hydrogen 3.299 N/A ALA 345.A N LEU 170.A O no hydrogen 2.789 N/A CYS 346.A SG SER 344.A OG no hydrogen 3.476 N/A ARG 347.A NH1 PHE 267.A O no hydrogen 3.202 N/A THR 348.A OG1 ALA 349.A O no hydrogen 3.298 N/A ALA 350.A N THR 286.A O no hydrogen 3.330 N/A GLU 352.A N ARG 284.A O no hydrogen 2.988 N/A PHE 355.A N SER 282.A O no hydrogen 2.938 N/A THR 357.A N ASN 280.A O no hydrogen 2.851 N/A CYS 363.A SG GLU 361.A O no hydrogen 3.811 N/A GLY 364.A N ASP 362.A OD1 no hydrogen 3.174 N/A THR 370.A OG1 SER 373.A OG no hydrogen 2.422 N/A SER 373.A N THR 370.A OG1 no hydrogen 3.008 N/A SER 373.A OG THR 370.A OG1 no hydrogen 2.422 N/A ARG 374.A N THR 370.A O no hydrogen 3.240 N/A ARG 374.A NE ASP 371.A OD2 no hydrogen 3.372 N/A ARG 374.A NH1 GLN 369.A O no hydrogen 3.302 N/A ARG 374.A NH1 GLN 369.A OE1 no hydrogen 2.558 N/A ARG 374.A NH2 ASP 371.A OD2 no hydrogen 3.230 N/A SER 375.A N ASP 371.A O no hydrogen 2.685 N/A SER 375.A OG ASP 371.A O no hydrogen 3.394 N/A SER 375.A OG GLU 372.A O no hydrogen 2.576 N/A HIS 376.A ND1 GLU 372.A O no hydrogen 3.256 N/A