Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4i8x_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASP 5.A N ALA 2.A O no hydrogen 2.882 N/A GLN 6.A N ALA 2.A O no hydrogen 2.997 N/A LEU 7.A N LEU 3.A O no hydrogen 2.969 N/A ILE 8.A N LYS 4.A O no hydrogen 2.807 N/A ASN 10.A ND2 LEU 12.A O no hydrogen 2.918 N/A LYS 13.A NZ GLU 15.A OE2 no hydrogen 2.557 N/A GLN 19.A N ASP 45.A OD2 no hydrogen 3.072 N/A GLN 19.A NE2 VAL 17.A O no hydrogen 3.271 N/A ASN 20.A N ASP 45.A OD1 no hydrogen 2.853 N/A ASN 20.A N ASP 45.A OD2 no hydrogen 3.336 N/A LYS 21.A NZ GLU 46.A OE2 no hydrogen 2.896 N/A LYS 21.A NZ VAL 84.A O no hydrogen 2.594 N/A LYS 21.A NZ ALA 86.A O no hydrogen 2.971 N/A ILE 22.A N GLU 46.A O no hydrogen 2.948 N/A THR 23.A N LEU 90.A O no hydrogen 2.901 N/A THR 23.A OG1 SER 88.A OG no hydrogen 2.677 N/A VAL 24.A N ALA 48.A O no hydrogen 2.869 N/A VAL 25.A N ILE 92.A O no hydrogen 2.780 N/A GLY 26.A N VAL 50.A O no hydrogen 2.751 N/A VAL 27.A N ASP 51.A OD2 no hydrogen 2.857 N/A MET 32.A N GLY 28.A O no hydrogen 3.037 N/A ALA 33.A N ALA 29.A O no hydrogen 3.109 N/A CYS 34.A N VAL 30.A O no hydrogen 3.058 N/A CYS 34.A SG VAL 30.A O no hydrogen 3.252 N/A ALA 35.A N GLY 31.A O no hydrogen 2.975 N/A ILE 36.A N MET 32.A O no hydrogen 2.981 N/A SER 37.A N ALA 33.A O no hydrogen 3.070 N/A SER 37.A OG ALA 33.A O no hydrogen 2.841 N/A ILE 38.A N CYS 34.A O no hydrogen 2.876 N/A LEU 39.A N ALA 35.A O no hydrogen 2.816 N/A MET 40.A N ILE 36.A O no hydrogen 2.917 N/A LYS 41.A N SER 37.A O no hydrogen 3.154 N/A LYS 41.A N ILE 38.A O no hydrogen 3.257 N/A LYS 41.A NZ GLU 250.A OE1 no hydrogen 3.036 N/A ASP 42.A N LEU 39.A O no hydrogen 3.274 N/A ASP 45.A N ASN 20.A O no hydrogen 2.961 N/A LEU 47.A N LYS 75.A O no hydrogen 2.961 N/A ALA 48.A N ILE 22.A O no hydrogen 3.010 N/A LEU 49.A N VAL 77.A O no hydrogen 2.880 N/A VAL 50.A N VAL 24.A O no hydrogen 3.119 N/A MET 53.A N ASP 51.A OD1 no hydrogen 2.958 N/A LYS 56.A NZ GLU 60.A OE2 no hydrogen 2.818 N/A LEU 57.A N MET 53.A O no hydrogen 2.979 N/A LYS 58.A N GLU 54.A O no hydrogen 2.964 N/A GLY 59.A N ASP 55.A O no hydrogen 2.934 N/A GLU 60.A N LYS 56.A O no hydrogen 2.967 N/A MET 61.A N LEU 57.A O no hydrogen 3.012 N/A MET 62.A N LYS 58.A O no hydrogen 2.996 N/A ASP 63.A N GLY 59.A O no hydrogen 2.995 N/A LEU 64.A N GLU 60.A O no hydrogen 3.106 N/A GLN 65.A N MET 61.A O no hydrogen 2.835 N/A GLN 65.A NE2 ILE 76.A O no hydrogen 3.070 N/A HIS 66.A N MET 62.A O no hydrogen 2.945 N/A GLY 67.A N LEU 64.A O no hydrogen 2.870 N/A SER 68.A N GLN 65.A O no hydrogen 2.947 N/A SER 68.A OG GLN 65.A O no hydrogen 2.557 N/A PHE 70.A N GLY 67.A O no hydrogen 2.798 N/A LEU 71.A N SER 68.A O no hydrogen 2.976 N/A THR 73.A OG1 ALA 44.A O no hydrogen 3.215 N/A VAL 77.A N LEU 47.A O no hydrogen 2.852 N/A GLY 79.A N LEU 49.A O no hydrogen 3.278 N/A LYS 80.A NZ GLU 54.A OE1 no hydrogen 3.416 N/A LYS 80.A NZ GLU 54.A OE2 no hydrogen 3.443 N/A SER 83.A N ASP 81.A OD1 no hydrogen 2.971 N/A SER 83.A OG ASP 81.A OD1 no hydrogen 2.400 N/A VAL 84.A N ASP 81.A O no hydrogen 3.494 N/A THR 85.A N TYR 82.A O no hydrogen 2.917 N/A THR 85.A OG1 TYR 82.A O no hydrogen 2.613 N/A ALA 86.A N SER 83.A O no hydrogen 3.096 N/A ASN 87.A N TYR 116.A O no hydrogen 2.921 N/A SER 88.A N SER 117.A OG no hydrogen 2.840 N/A SER 88.A OG THR 23.A OG1 no hydrogen 2.677 N/A SER 88.A OG THR 85.A O no hydrogen 2.609 N/A LYS 89.A N LYS 21.A O no hydrogen 2.815 N/A LYS 89.A NZ GLN 19.A O no hydrogen 2.666 N/A VAL 91.A N LYS 121.A O no hydrogen 3.000 N/A ILE 92.A N THR 23.A O no hydrogen 2.755 N/A ILE 93.A N LEU 123.A O no hydrogen 2.716 N/A THR 94.A N VAL 25.A O no hydrogen 2.784 N/A THR 94.A OG1 VAL 25.A O no hydrogen 2.635 N/A THR 94.A OG1 GLY 26.A O no hydrogen 3.033 N/A GLN 100.A NE2 ASN 104.A OD1 no hydrogen 3.518 N/A GLN 100.A NE2 GLN 320.A O no hydrogen 3.086 N/A ARG 101.A N LEU 98.A O no hydrogen 2.798 N/A VAL 103.A N VAL 99.A O no hydrogen 2.719 N/A ASN 104.A N GLN 100.A O no hydrogen 2.959 N/A ILE 105.A N ARG 101.A O no hydrogen 2.805 N/A PHE 106.A N ASN 102.A O no hydrogen 2.630 N/A LYS 107.A N VAL 103.A O no hydrogen 2.715 N/A PHE 108.A N ILE 105.A O no hydrogen 2.739 N/A ILE 109.A N ILE 105.A O no hydrogen 3.064 N/A ILE 110.A N PHE 106.A O no hydrogen 2.952 N/A ASN 112.A N PHE 108.A O no hydrogen 3.414 N/A VAL 113.A N ILE 109.A O no hydrogen 2.865 N/A VAL 114.A N ILE 110.A O no hydrogen 2.794 N/A LYS 115.A N PRO 111.A O no hydrogen 2.926 N/A LYS 115.A NZ TYR 116.A OH no hydrogen 3.318 N/A TYR 116.A N VAL 113.A O no hydrogen 3.270 N/A SER 117.A N VAL 113.A O no hydrogen 2.924 N/A CYS 120.A N SER 117.A O no hydrogen 3.493 N/A CYS 120.A SG SER 117.A O no hydrogen 3.483 N/A CYS 120.A SG LYS 121.A O no hydrogen 3.680 N/A LYS 121.A N LYS 89.A O no hydrogen 2.923 N/A LYS 121.A NZ LYS 89.A O no hydrogen 3.123 N/A LEU 122.A N ARG 146.A O no hydrogen 2.696 N/A LEU 123.A N VAL 91.A O no hydrogen 2.990 N/A VAL 124.A N ILE 148.A O no hydrogen 2.764 N/A VAL 125.A N ILE 93.A O no hydrogen 2.915 N/A SER 126.A OG ILE 93.A O no hydrogen 3.332 N/A SER 126.A OG ALA 95.A O no hydrogen 2.614 N/A LEU 132.A N PRO 128.A O no hydrogen 2.998 N/A THR 133.A N VAL 129.A O no hydrogen 2.985 N/A THR 133.A OG1 VAL 129.A O no hydrogen 2.641 N/A TYR 134.A N ASP 130.A O no hydrogen 3.372 N/A VAL 135.A N ILE 131.A O no hydrogen 2.880 N/A ALA 136.A N LEU 132.A O no hydrogen 2.785 N/A TRP 137.A N THR 133.A O no hydrogen 2.865 N/A LYS 138.A N TYR 134.A O no hydrogen 2.863 N/A ILE 139.A N VAL 135.A O no hydrogen 3.010 N/A SER 140.A N ALA 136.A O no hydrogen 2.918 N/A SER 140.A OG TRP 137.A O no hydrogen 2.855 N/A GLY 141.A N TRP 137.A O no hydrogen 3.275 N/A PHE 142.A N SER 140.A OG no hydrogen 2.826 N/A ASN 145.A ND2 ASN 287.A O no hydrogen 2.874 N/A ARG 146.A N PRO 143.A O no hydrogen 3.029 N/A ARG 146.A NH1 PRO 118.A O no hydrogen 3.507 N/A ARG 146.A NH1 CYS 120.A O no hydrogen 2.694 N/A VAL 147.A N LYS 144.A O no hydrogen 3.291 N/A ILE 148.A N LEU 122.A O no hydrogen 2.751 N/A GLY 149.A N SER 263.A O no hydrogen 3.012 N/A SER 150.A N VAL 124.A O no hydrogen 2.906 N/A SER 150.A OG VAL 124.A O no hydrogen 3.443 N/A CYS 152.A N SER 279.A OG no hydrogen 2.819 N/A CYS 152.A SG GLY 180.A O no hydrogen 3.928 N/A CYS 152.A SG SER 279.A OG no hydrogen 3.693 N/A ASN 153.A N SER 150.A O no hydrogen 3.092 N/A SER 156.A N CYS 152.A O no hydrogen 2.880 N/A SER 156.A OG CYS 152.A O no hydrogen 3.112 N/A ALA 157.A N ASN 153.A O no hydrogen 3.108 N/A ARG 158.A N LEU 154.A O no hydrogen 2.714 N/A ARG 158.A NH2 ASP 155.A OD2 no hydrogen 3.103 N/A PHE 159.A N ASP 155.A O no hydrogen 2.790 N/A ARG 160.A N SER 156.A O no hydrogen 2.791 N/A ARG 160.A NE ALA 171.A O no hydrogen 3.379 N/A ARG 160.A NE CYS 174.A O no hydrogen 2.697 N/A ARG 160.A NH2 ALA 171.A O no hydrogen 3.192 N/A ARG 160.A NH2 CYS 174.A O no hydrogen 3.495 N/A TYR 161.A N ALA 157.A O no hydrogen 2.932 N/A LEU 162.A N ARG 158.A O no hydrogen 2.969 N/A MET 163.A N PHE 159.A O no hydrogen 2.835 N/A GLY 164.A N ARG 160.A O no hydrogen 2.967 N/A GLU 165.A N TYR 161.A O no hydrogen 2.974 N/A ARG 166.A N LEU 162.A O no hydrogen 3.237 N/A ARG 166.A NH1 GLU 214.A O no hydrogen 2.889 N/A LEU 167.A N MET 163.A O no hydrogen 3.071 N/A LEU 167.A N GLY 164.A O no hydrogen 3.280 N/A GLY 168.A N GLY 164.A O no hydrogen 2.776 N/A VAL 169.A N GLY 164.A O no hydrogen 3.209 N/A LEU 172.A N HIS 170.A ND1 no hydrogen 2.826 N/A SER 173.A N HIS 170.A O no hydrogen 2.952 N/A CYS 174.A N ALA 171.A O no hydrogen 2.996 N/A CYS 174.A SG VAL 169.A O no hydrogen 3.964 N/A CYS 174.A SG HIS 170.A O no hydrogen 3.537 N/A HIS 175.A N ASN 194.A O no hydrogen 2.995 N/A ILE 178.A N SER 156.A OG no hydrogen 3.145 N/A LEU 179.A N VAL 187.A O no hydrogen 2.858 N/A GLY 180.A N SER 279.A O no hydrogen 2.900 N/A HIS 182.A N ASP 130.A OD2 no hydrogen 2.836 N/A SER 186.A N GLY 183.A O no hydrogen 2.967 N/A SER 186.A OG GLY 183.A O no hydrogen 3.033 N/A VAL 187.A N LEU 179.A O no hydrogen 2.668 N/A VAL 189.A N TRP 177.A O no hydrogen 2.987 N/A GLY 192.A N VAL 189.A O no hydrogen 3.085 N/A MET 193.A N TRP 190.A O no hydrogen 3.268 N/A ASN 194.A N HIS 175.A O no hydrogen 3.058 N/A VAL 198.A N VAL 195.A O no hydrogen 2.870 N/A SER 199.A OG THR 202.A OG1 no hydrogen 3.172 N/A LEU 200.A N MET 193.A O no hydrogen 3.018 N/A LYS 201.A NZ PRO 205.A O no hydrogen 3.136 N/A LYS 201.A NZ LEU 207.A O no hydrogen 2.829 N/A THR 202.A N SER 199.A OG no hydrogen 3.164 N/A THR 202.A OG1 SER 199.A OG no hydrogen 3.172 N/A LEU 203.A N SER 199.A O no hydrogen 3.297 N/A HIS 204.A N LEU 200.A O no hydrogen 2.838 N/A HIS 204.A NE2 ASP 212.A OD1 no hydrogen 2.840 N/A LEU 207.A N HIS 204.A O no hydrogen 2.771 N/A GLY 208.A N ASP 212.A OD2 no hydrogen 3.159 N/A THR 209.A N GLU 206.A O no hydrogen 2.951 N/A THR 209.A OG1 GLU 206.A O no hydrogen 2.746 N/A THR 209.A OG1 GLU 206.A OE2 no hydrogen 2.997 N/A ASP 212.A N THR 209.A O no hydrogen 3.235 N/A GLU 214.A N ASP 212.A OD1 no hydrogen 2.897 N/A GLN 215.A N ASP 212.A O no hydrogen 2.973 N/A GLN 215.A NE2 ASP 210.A O no hydrogen 3.642 N/A GLN 215.A NE2 ASP 212.A O no hydrogen 2.927 N/A TRP 216.A N ASP 212.A OD2 no hydrogen 3.104 N/A TRP 216.A NE1 GLU 214.A OE2 no hydrogen 2.935 N/A LYS 217.A NZ ASP 210.A OD2 no hydrogen 3.425 N/A GLN 218.A N GLN 215.A O no hydrogen 2.849 N/A VAL 219.A N TRP 216.A O no hydrogen 2.828 N/A LYS 221.A N LYS 217.A O no hydrogen 3.237 N/A LYS 221.A NZ ASP 225.A OD2 no hydrogen 3.288 N/A GLN 222.A N GLN 218.A O no hydrogen 2.697 N/A VAL 223.A N VAL 219.A O no hydrogen 2.923 N/A VAL 224.A N HIS 220.A O no hydrogen 2.894 N/A ASP 225.A N LYS 221.A O no hydrogen 2.920 N/A SER 226.A N VAL 223.A O no hydrogen 3.130 N/A SER 226.A OG VAL 223.A O no hydrogen 2.681 N/A GLU 229.A N ASP 225.A O no hydrogen 2.955 N/A VAL 230.A N SER 226.A O no hydrogen 2.839 N/A ILE 231.A N ALA 227.A O no hydrogen 2.820 N/A LYS 232.A N TYR 228.A O no hydrogen 2.990 N/A LEU 233.A N VAL 230.A O no hydrogen 2.993 N/A LYS 234.A N VAL 230.A O no hydrogen 2.873 N/A LYS 234.A NZ THR 238.A OG1 no hydrogen 3.204 N/A GLY 235.A N ILE 231.A O no hydrogen 2.644 N/A GLY 242.A N THR 238.A O no hydrogen 2.887 N/A LEU 243.A N TRP 239.A O no hydrogen 2.926 N/A SER 244.A N ALA 240.A O no hydrogen 2.963 N/A SER 244.A OG ALA 240.A O no hydrogen 3.279 N/A SER 244.A OG ILE 241.A O no hydrogen 2.740 N/A VAL 245.A N ILE 241.A O no hydrogen 2.977 N/A ALA 246.A N GLY 242.A O no hydrogen 2.978 N/A ASP 247.A N LEU 243.A O no hydrogen 3.104 N/A LEU 248.A N SER 244.A O no hydrogen 3.378 N/A ALA 249.A N VAL 245.A O no hydrogen 2.876 N/A GLU 250.A N ALA 246.A O no hydrogen 2.899 N/A SER 251.A N ASP 247.A O no hydrogen 3.289 N/A SER 251.A OG HIS 260.A NE2 no hydrogen 2.701 N/A ILE 252.A N LEU 248.A O no hydrogen 3.157 N/A MET 253.A N ALA 249.A O no hydrogen 2.892 N/A LYS 254.A N GLU 250.A O no hydrogen 3.043 N/A LYS 254.A NZ GLU 250.A OE2 no hydrogen 2.968 N/A ASN 255.A N ILE 252.A O no hydrogen 3.208 N/A LEU 256.A N SER 251.A O no hydrogen 2.862 N/A ARG 257.A NH1 SER 290.A OG no hydrogen 3.210 N/A ARG 257.A NH2 ASP 291.A OD1 no hydrogen 3.092 N/A ARG 258.A NE SER 251.A OG no hydrogen 2.941 N/A ARG 258.A NH1 ASP 247.A OD2 no hydrogen 2.826 N/A ARG 258.A NH1 SER 251.A OG no hydrogen 2.860 N/A ARG 258.A NH2 ASP 247.A OD2 no hydrogen 3.227 N/A HIS 260.A N CYS 282.A O no hydrogen 2.986 N/A HIS 260.A NE2 SER 251.A OG no hydrogen 2.701 N/A SER 263.A N GLY 149.A O no hydrogen 2.891 N/A SER 263.A OG ASP 130.A OD1 no hydrogen 2.727 N/A THR 264.A N LEU 278.A O no hydrogen 2.971 N/A LEU 266.A N VAL 276.A O no hydrogen 3.092 N/A GLY 268.A N ILE 272.A O no hydrogen 2.893 N/A LEU 269.A N LEU 266.A O no hydrogen 2.991 N/A TYR 270.A OH VAL 293.A O no hydrogen 2.589 N/A ILE 272.A N LEU 269.A O no hydrogen 2.885 N/A VAL 276.A N GLU 274.A O no hydrogen 3.129 N/A LEU 278.A N THR 264.A O no hydrogen 3.242 N/A SER 279.A N GLY 180.A O no hydrogen 2.960 N/A VAL 280.A N ILE 262.A O no hydrogen 3.241 N/A CYS 282.A N HIS 260.A O no hydrogen 2.795 N/A CYS 282.A SG ILE 262.A O no hydrogen 3.692 N/A CYS 282.A SG VAL 280.A O no hydrogen 3.337 N/A VAL 283.A N ASP 291.A O no hydrogen 2.797 N/A LEU 284.A N ARG 258.A O no hydrogen 2.962 N/A GLY 285.A N GLY 288.A O no hydrogen 3.027 N/A GLN 286.A N ASN 255.A OD1 no hydrogen 2.904 N/A GLY 288.A N GLY 285.A O no hydrogen 2.824 N/A ILE 289.A N ASN 145.A O no hydrogen 2.995 N/A SER 290.A N VAL 283.A O no hydrogen 3.406 N/A SER 290.A OG ASP 291.A OD1 no hydrogen 2.567 N/A VAL 293.A N PRO 281.A O no hydrogen 2.824 N/A VAL 295.A N TYR 270.A OH no hydrogen 2.864 N/A THR 298.A N GLU 301.A OE2 no hydrogen 2.848 N/A GLU 301.A N THR 298.A OG1 no hydrogen 3.003 N/A GLU 302.A N THR 298.A O no hydrogen 2.885 N/A ALA 303.A N SER 299.A O no hydrogen 3.128 N/A HIS 304.A N GLU 300.A O no hydrogen 3.043 N/A HIS 304.A N GLU 301.A O no hydrogen 3.153 N/A HIS 304.A NE2 SER 185.A O no hydrogen 2.865 N/A LEU 305.A N GLU 301.A O no hydrogen 3.149 N/A LYS 306.A N GLU 302.A O no hydrogen 3.007 N/A LYS 307.A N ALA 303.A O no hydrogen 3.122 N/A SER 308.A N HIS 304.A O no hydrogen 3.193 N/A SER 308.A OG GLU 181.A OE1 no hydrogen 3.074 N/A SER 308.A OG HIS 304.A O no hydrogen 3.392 N/A ALA 309.A N LEU 305.A O no hydrogen 2.950 N/A ASP 310.A N LYS 306.A O no hydrogen 3.027 N/A THR 311.A N LYS 307.A O no hydrogen 2.820 N/A THR 311.A OG1 LYS 307.A O no hydrogen 2.828 N/A LEU 312.A N SER 308.A O no hydrogen 2.823 N/A TRP 313.A N ALA 309.A O no hydrogen 2.816 N/A GLY 314.A N ASP 310.A O no hydrogen 2.924 N/A ILE 315.A N THR 311.A O no hydrogen 3.356 N/A GLN 316.A N LEU 312.A O no hydrogen 2.830 N/A GLN 316.A NE2 ASP 275.A O no hydrogen 2.778 N/A LYS 317.A N TRP 313.A O no hydrogen 2.729 N/A GLU 318.A N ILE 315.A O no hydrogen 3.032 N/A GLN 320.A N GLN 100.A OE1 no hydrogen 3.012 N/A