Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4ixr_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 6.A N ASN 3.A OD1 no hydrogen 3.206 N/A ARG 7.A N ASN 3.A O no hydrogen 2.820 N/A PHE 8.A N LEU 4.A O no hydrogen 2.797 N/A CYS 9.A N TRP 5.A O no hydrogen 2.948 N/A CYS 9.A SG TRP 5.A O no hydrogen 3.105 N/A ASN 10.A N GLU 6.A O no hydrogen 3.205 N/A ASN 10.A ND2 GLU 6.A O no hydrogen 2.250 N/A TRP 11.A N ARG 7.A O no hydrogen 2.853 N/A VAL 12.A N PHE 8.A O no hydrogen 2.982 N/A THR 13.A N CYS 9.A O no hydrogen 3.109 N/A SER 14.A N TRP 11.A O no hydrogen 3.134 N/A ASP 16.A N SER 14.A OG no hydrogen 3.114 N/A ASN 17.A ND2 TRP 11.A O no hydrogen 2.966 N/A ARG 18.A NH1 ARG 18.A O no hydrogen 2.630 N/A TYR 20.A OH GLU 123.A OE2 no hydrogen 2.374 N/A TRP 23.A N GLU 123.A OE1 no hydrogen 3.044 N/A TRP 23.A N GLU 123.A OE2 no hydrogen 2.924 N/A PHE 24.A N GLU 123.A OE1 no hydrogen 3.493 N/A VAL 26.A N GLY 22.A O no hydrogen 3.191 N/A VAL 26.A N TRP 23.A O no hydrogen 3.305 N/A ILE 27.A N PHE 24.A O no hydrogen 3.078 N/A MET 28.A N PHE 24.A O no hydrogen 2.771 N/A ILE 29.A N GLY 25.A O no hydrogen 2.896 N/A THR 31.A N ILE 27.A O no hydrogen 3.344 N/A THR 31.A OG1 ILE 27.A O no hydrogen 2.790 N/A THR 31.A OG1 MET 28.A O no hydrogen 2.686 N/A LEU 32.A N MET 28.A O no hydrogen 2.764 N/A LEU 33.A N ILE 29.A O no hydrogen 3.210 N/A ALA 34.A N PRO 30.A O no hydrogen 3.058 N/A ALA 35.A N THR 31.A O no hydrogen 3.128 N/A THR 36.A N LEU 32.A O no hydrogen 2.969 N/A ILE 37.A N LEU 33.A O no hydrogen 3.049 N/A CYS 38.A N ALA 34.A O no hydrogen 2.917 N/A PHE 39.A N ALA 35.A O no hydrogen 2.893 N/A VAL 40.A N THR 36.A O no hydrogen 2.872 N/A ILE 41.A N ILE 37.A O no hydrogen 3.162 N/A ALA 42.A N CYS 38.A O no hydrogen 2.969 N/A PHE 43.A N PHE 39.A O no hydrogen 2.823 N/A ALA 45.A N ILE 41.A O no hydrogen 2.819 N/A ALA 46.A N ALA 42.A O no hydrogen 2.814 N/A VAL 49.A N VAL 58.A O no hydrogen 2.810 N/A ASP 50.A N TYR 98.A O no hydrogen 3.162 N/A ILE 51.A N VAL 49.A O no hydrogen 2.840 N/A GLY 53.A N ASP 50.A O no hydrogen 3.240 N/A ARG 55.A N ASP 50.A OD2 no hydrogen 2.864 N/A GLU 56.A N ASP 50.A OD1 no hydrogen 2.655 N/A VAL 58.A N VAL 49.A O no hydrogen 2.608 N/A SER 59.A OG TYR 64.A O no hydrogen 3.434 N/A SER 61.A OG ILE 44.A O no hydrogen 3.259 N/A SER 61.A OG ALA 46.A O no hydrogen 2.778 N/A LEU 62.A N PHE 43.A O no hydrogen 2.919 N/A LEU 63.A N ILE 44.A O no hydrogen 2.855 N/A TYR 64.A N SER 61.A O no hydrogen 3.067 N/A GLY 65.A N LEU 62.A O no hydrogen 3.104 N/A ASN 66.A N SER 61.A O no hydrogen 3.269 N/A ASN 66.A N LEU 62.A O no hydrogen 3.371 N/A ASN 66.A ND2 SER 59.A O no hydrogen 3.214 N/A ASN 66.A ND2 SER 61.A O no hydrogen 3.276 N/A ASN 66.A ND2 TYR 64.A O no hydrogen 3.659 N/A ASN 67.A N THR 70.A OG1 no hydrogen 3.066 N/A THR 70.A N ASN 67.A OD1 no hydrogen 2.868 N/A THR 70.A OG1 ASN 66.A OD1 no hydrogen 2.853 N/A THR 70.A OG1 ASN 67.A O no hydrogen 3.260 N/A THR 70.A OG1 ASN 67.A OD1 no hydrogen 3.016 N/A GLY 71.A N ASN 67.A O no hydrogen 2.555 N/A ALA 72.A N GLY 60.A O no hydrogen 2.489 N/A VAL 73.A N LEU 165.A O no hydrogen 2.934 N/A SER 77.A N ASN 99.A O no hydrogen 2.931 N/A SER 77.A OG ASP 50.A O no hydrogen 3.476 N/A ALA 79.A N SER 77.A OG no hydrogen 2.958 N/A ILE 80.A N SER 77.A O no hydrogen 3.272 N/A GLY 81.A N SER 77.A O no hydrogen 3.349 N/A HIS 83.A N ILE 80.A O no hydrogen 3.026 N/A TYR 85.A N GLN 104.A OE1 no hydrogen 2.910 N/A TYR 85.A OH GLU 95.A OE2 no hydrogen 2.771 N/A GLU 89.A N PRO 86.A O no hydrogen 3.008 N/A ALA 90.A N ILE 87.A O no hydrogen 3.106 N/A ALA 91.A N GLU 95.A OE1 no hydrogen 3.155 N/A ALA 91.A N GLU 95.A OE2 no hydrogen 3.397 N/A TRP 96.A N SER 92.A O no hydrogen 2.996 N/A LEU 97.A N LEU 93.A O no hydrogen 2.708 N/A TYR 98.A N ASP 94.A O no hydrogen 3.146 N/A TYR 98.A N GLU 95.A O no hydrogen 3.136 N/A ASN 99.A N GLU 95.A O no hydrogen 3.078 N/A ASN 99.A ND2 GLU 95.A O no hydrogen 2.729 N/A GLY 101.A N TRP 96.A O no hydrogen 2.707 N/A TYR 103.A OH MET 163.A O no hydrogen 2.933 N/A GLN 104.A NE2 HIS 83.A O no hydrogen 3.240 N/A ILE 106.A N PRO 102.A O no hydrogen 2.908 N/A ILE 107.A N TYR 103.A O no hydrogen 2.954 N/A PHE 108.A N GLN 104.A O no hydrogen 2.979 N/A HIS 109.A N LEU 105.A O no hydrogen 3.315 N/A HIS 109.A ND1 LEU 105.A O no hydrogen 2.526 N/A PHE 110.A N ILE 106.A O no hydrogen 2.720 N/A LEU 111.A N ILE 107.A O no hydrogen 2.944 N/A LEU 112.A N PHE 108.A O no hydrogen 3.019 N/A GLY 113.A N HIS 109.A O no hydrogen 2.967 N/A ALA 114.A N PHE 110.A O no hydrogen 2.554 N/A SER 115.A N LEU 111.A O no hydrogen 3.098 N/A SER 115.A N LEU 112.A O no hydrogen 3.082 N/A SER 115.A OG LEU 111.A O no hydrogen 2.582 N/A CYS 116.A N LEU 112.A O no hydrogen 3.087 N/A CYS 116.A SG LEU 112.A O no hydrogen 3.676 N/A TYR 117.A N GLY 113.A O no hydrogen 2.720 N/A GLY 119.A N SER 115.A O no hydrogen 2.968 N/A ARG 120.A N CYS 116.A O no hydrogen 2.711 N/A GLN 121.A N TYR 117.A O no hydrogen 3.141 N/A TRP 122.A N GLY 119.A O no hydrogen 3.335 N/A GLU 123.A N GLY 119.A O no hydrogen 3.260 N/A LEU 124.A N ARG 120.A O no hydrogen 3.059 N/A SER 125.A OG TRP 122.A O no hydrogen 2.491 N/A TYR 126.A N TRP 122.A O no hydrogen 2.863 N/A ARG 127.A N GLU 123.A O no hydrogen 2.863 N/A ARG 127.A NE TYR 20.A OH no hydrogen 3.059 N/A ARG 127.A NH2 GLU 123.A OE2 no hydrogen 3.461 N/A LEU 128.A N LEU 124.A O no hydrogen 3.044 N/A GLY 129.A N TYR 126.A O no hydrogen 3.341 N/A MET 130.A N SER 125.A O no hydrogen 3.021 N/A ILE 134.A N PRO 132.A O no hydrogen 2.471 N/A VAL 136.A N TRP 133.A O no hydrogen 3.078 N/A ALA 137.A N TRP 133.A O no hydrogen 3.256 N/A ALA 137.A N ILE 134.A O no hydrogen 3.017 N/A TYR 138.A N ILE 134.A O no hydrogen 3.278 N/A TYR 138.A OH ALA 114.A O no hydrogen 3.394 N/A SER 139.A N VAL 136.A O no hydrogen 3.314 N/A SER 139.A OG VAL 136.A O no hydrogen 2.773 N/A LEU 142.A N TYR 138.A O no hydrogen 3.293 N/A ALA 143.A N SER 139.A O no hydrogen 2.844 N/A SER 144.A N ALA 140.A O no hydrogen 3.265 N/A SER 144.A N PRO 141.A O no hydrogen 3.293 N/A SER 144.A OG ALA 140.A O no hydrogen 3.030 N/A ALA 145.A N PRO 141.A O no hydrogen 3.246 N/A PHE 146.A N LEU 142.A O no hydrogen 2.908 N/A ALA 147.A N ALA 143.A O no hydrogen 3.097 N/A VAL 148.A N SER 144.A O no hydrogen 2.869 N/A PHE 149.A N ALA 145.A O no hydrogen 2.895 N/A LEU 150.A N PHE 146.A O no hydrogen 2.800 N/A ILE 151.A N PHE 146.A O no hydrogen 2.865 N/A TYR 152.A N ALA 147.A O no hydrogen 2.982 N/A TYR 152.A OH HIS 181.A NE2 no hydrogen 2.685 N/A ILE 154.A N LEU 150.A O no hydrogen 3.053 N/A GLY 155.A N ILE 151.A O no hydrogen 2.900 N/A GLN 156.A N TYR 152.A O no hydrogen 2.811 N/A GLN 156.A NE2 ALA 335.A O no hydrogen 3.310 N/A GLY 157.A N PRO 153.A O no hydrogen 2.664 N/A GLY 157.A N ILE 154.A O no hydrogen 3.262 N/A SER 158.A N PRO 153.A O no hydrogen 2.955 N/A SER 158.A OG ASN 78.A OD1 no hydrogen 3.125 N/A SER 158.A OG SER 160.A OG no hydrogen 2.660 N/A PHE 159.A N GLY 81.A O no hydrogen 3.046 N/A SER 160.A N SER 158.A OG no hydrogen 3.079 N/A SER 160.A OG ASN 78.A OD1 no hydrogen 3.278 N/A SER 160.A OG SER 158.A OG no hydrogen 2.660 N/A ASP 161.A N SER 158.A O no hydrogen 3.411 N/A GLY 162.A N PHE 159.A O no hydrogen 3.107 N/A MET 163.A N VAL 148.A O no hydrogen 3.374 N/A LEU 165.A N VAL 73.A O no hydrogen 3.141 N/A SER 168.A N ILE 69.A O no hydrogen 3.033 N/A SER 168.A OG ILE 69.A O no hydrogen 2.871 N/A THR 170.A N GLY 166.A O no hydrogen 2.961 N/A THR 170.A N ILE 167.A O no hydrogen 2.851 N/A THR 170.A OG1 GLY 166.A O no hydrogen 2.398 N/A PHE 171.A N ILE 167.A O no hydrogen 3.219 N/A ASN 172.A N SER 168.A O no hydrogen 3.052 N/A PHE 173.A N GLY 169.A O no hydrogen 3.291 N/A MET 174.A N THR 170.A O no hydrogen 3.220 N/A ILE 175.A N PHE 171.A O no hydrogen 2.988 N/A VAL 176.A N ASN 172.A O no hydrogen 2.998 N/A PHE 177.A N PHE 173.A O no hydrogen 2.955 N/A GLN 178.A N MET 174.A O no hydrogen 2.846 N/A GLN 178.A NE2 ASN 182.A OD1 no hydrogen 2.736 N/A GLN 178.A NE2 ASN 316.A OD1 no hydrogen 2.892 N/A ALA 179.A N ILE 175.A O no hydrogen 3.184 N/A GLU 180.A N VAL 176.A O no hydrogen 2.927 N/A HIS 181.A N PHE 177.A O no hydrogen 2.768 N/A HIS 181.A ND1 ASN 289.A OD1 no hydrogen 2.541 N/A HIS 181.A NE2 TYR 152.A OH no hydrogen 2.685 N/A ASN 182.A N GLN 178.A O no hydrogen 2.718 N/A ASN 182.A ND2 PHE 291.A O no hydrogen 3.335 N/A LEU 184.A N GLN 178.A OE1 no hydrogen 3.145 N/A MET 185.A N ASN 182.A O no hydrogen 3.093 N/A HIS 186.A N ILE 183.A O no hydrogen 2.987 N/A PHE 188.A N HIS 186.A ND1 no hydrogen 3.078 N/A GLN 190.A N HIS 186.A O no hydrogen 3.082 N/A LEU 191.A N PRO 187.A O no hydrogen 2.831 N/A GLY 192.A N PHE 188.A O no hydrogen 3.121 N/A VAL 193.A N HIS 189.A O no hydrogen 3.102 N/A ALA 194.A N GLN 190.A O no hydrogen 3.093 N/A GLY 195.A N LEU 191.A O no hydrogen 2.961 N/A VAL 196.A N GLY 192.A O no hydrogen 2.819 N/A PHE 197.A N VAL 193.A O no hydrogen 2.519 N/A GLY 198.A N ALA 194.A O no hydrogen 2.841 N/A GLY 199.A N GLY 195.A O no hydrogen 2.862 N/A ALA 200.A N VAL 196.A O no hydrogen 3.083 N/A LEU 201.A N PHE 197.A O no hydrogen 2.765 N/A PHE 202.A N GLY 198.A O no hydrogen 2.522 N/A CYS 203.A N GLY 199.A O no hydrogen 2.670 N/A ALA 204.A N ALA 200.A O no hydrogen 3.119 N/A MET 205.A N LEU 201.A O no hydrogen 2.729 N/A HIS 206.A N PHE 202.A O no hydrogen 2.685 N/A GLY 207.A N CYS 203.A O no hydrogen 3.089 N/A SER 208.A N ALA 204.A O no hydrogen 2.953 N/A SER 208.A OG ALA 204.A O no hydrogen 2.867 N/A SER 208.A OG MET 205.A O no hydrogen 2.864 N/A LEU 209.A N MET 205.A O no hydrogen 3.061 N/A VAL 210.A N HIS 206.A O no hydrogen 3.085 N/A THR 211.A N GLY 207.A O no hydrogen 3.065 N/A SER 212.A N SER 208.A O no hydrogen 2.697 N/A SER 212.A OG SER 208.A O no hydrogen 2.821 N/A SER 212.A OG LEU 209.A O no hydrogen 2.597 N/A SER 213.A N VAL 210.A O no hydrogen 2.980 N/A SER 213.A OG LEU 209.A O no hydrogen 3.095 N/A SER 213.A OG VAL 210.A O no hydrogen 3.352 N/A SER 213.A OG ASN 238.A O no hydrogen 3.467 N/A ILE 215.A N THR 236.A O no hydrogen 3.426 N/A THR 219.A OG1 GLU 222.A OE1 no hydrogen 3.136 N/A ASN 225.A N SER 223.A OG no hydrogen 3.253 N/A TYR 226.A N SER 223.A O no hydrogen 3.382 N/A TYR 228.A N ASN 225.A O no hydrogen 3.196 N/A LYS 229.A N GLN 232.A OE1 no hydrogen 3.204 N/A GLN 232.A NE2 GLU 234.A O no hydrogen 3.171 N/A THR 236.A N GLU 235.A OE2 no hydrogen 2.842 N/A ASN 238.A N SER 213.A O no hydrogen 2.805 N/A ALA 241.A N ASN 238.A O no hydrogen 3.090 N/A ALA 241.A N ASN 238.A OD1 no hydrogen 3.235 N/A ALA 242.A N ASN 238.A O no hydrogen 2.883 N/A HIS 243.A N ILE 239.A O no hydrogen 3.005 N/A HIS 243.A ND1 SER 255.A OG no hydrogen 2.820 N/A GLY 244.A N VAL 240.A O no hydrogen 3.127 N/A TYR 245.A N ALA 241.A O no hydrogen 3.204 N/A PHE 246.A N ALA 242.A O no hydrogen 3.070 N/A GLY 247.A N HIS 243.A O no hydrogen 2.801 N/A ARG 248.A N TYR 245.A O no hydrogen 2.908 N/A ARG 248.A NH1 GLY 244.A O no hydrogen 3.113 N/A LEU 249.A N TYR 245.A O no hydrogen 3.004 N/A LEU 249.A N PHE 246.A O no hydrogen 3.275 N/A ILE 250.A N PHE 246.A O no hydrogen 3.514 N/A ALA 254.A N PHE 251.A O no hydrogen 2.757 N/A SER 255.A OG HIS 243.A ND1 no hydrogen 2.820 N/A ARG 260.A N ASN 258.A OD1 no hydrogen 2.873 N/A SER 261.A N ASN 258.A OD1 no hydrogen 3.343 N/A LEU 262.A N ASN 258.A O no hydrogen 2.813 N/A HIS 263.A N SER 259.A O no hydrogen 2.986 N/A HIS 263.A ND1 SER 259.A O no hydrogen 2.534 N/A PHE 264.A N ARG 260.A O no hydrogen 3.175 N/A PHE 265.A N SER 261.A O no hydrogen 3.257 N/A LEU 266.A N LEU 262.A O no hydrogen 2.853 N/A ALA 267.A N HIS 263.A O no hydrogen 3.085 N/A ALA 267.A N PHE 264.A O no hydrogen 3.048 N/A ALA 268.A N PHE 264.A O no hydrogen 2.651 N/A TRP 269.A N PHE 265.A O no hydrogen 3.195 N/A TRP 269.A NE1 ALA 194.A O no hydrogen 3.055 N/A VAL 271.A N ALA 267.A O no hydrogen 3.478 N/A VAL 272.A N ALA 268.A O no hydrogen 2.861 N/A GLY 273.A N TRP 269.A O no hydrogen 2.899 N/A VAL 274.A N PRO 270.A O no hydrogen 2.740 N/A TRP 275.A N VAL 271.A O no hydrogen 2.905 N/A TRP 275.A NE1 SER 139.A OG no hydrogen 2.915 N/A PHE 276.A N VAL 272.A O no hydrogen 3.211 N/A THR 277.A N GLY 273.A O no hydrogen 3.254 N/A ALA 278.A N VAL 274.A O no hydrogen 2.835 N/A LEU 279.A N TRP 275.A O no hydrogen 2.962 N/A GLY 280.A N PHE 276.A O no hydrogen 2.633 N/A ILE 281.A N THR 277.A O no hydrogen 3.273 N/A SER 282.A N ALA 278.A O no hydrogen 3.136 N/A SER 282.A OG ALA 278.A O no hydrogen 3.074 N/A THR 283.A N LEU 279.A O no hydrogen 2.803 N/A THR 283.A N GLY 280.A O no hydrogen 3.151 N/A THR 283.A OG1 LEU 279.A O no hydrogen 3.053 N/A MET 284.A N GLY 280.A O no hydrogen 2.865 N/A PHE 286.A N THR 283.A O no hydrogen 2.982 N/A GLY 290.A N HIS 181.A O no hydrogen 3.261 N/A PHE 291.A N MET 185.A O no hydrogen 2.795 N/A ASN 294.A N ASN 292.A OD1 no hydrogen 3.199 N/A HIS 295.A N ASP 310.A OD2 no hydrogen 3.205 N/A ASP 299.A N ASN 303.A O no hydrogen 2.923 N/A LYS 301.A N ASP 299.A OD1 no hydrogen 3.318 N/A GLY 302.A N ASP 299.A OD1 no hydrogen 2.976 N/A ASN 303.A ND2 ASP 299.A OD2 no hydrogen 3.412 N/A ILE 305.A N VAL 297.A O no hydrogen 3.044 N/A THR 307.A N ASP 310.A OD1 no hydrogen 2.881 N/A THR 307.A OG1 ASP 310.A OD1 no hydrogen 3.040 N/A ASP 310.A N THR 307.A O no hydrogen 3.192 N/A ILE 311.A N THR 307.A O no hydrogen 3.401 N/A ILE 312.A N TRP 308.A O no hydrogen 2.926 N/A ASN 313.A N ALA 309.A O no hydrogen 3.189 N/A ARG 314.A N ASP 310.A O no hydrogen 3.063 N/A ALA 315.A N ILE 311.A O no hydrogen 3.438 N/A ASN 316.A N ILE 312.A O no hydrogen 2.973 N/A ASN 316.A ND2 ASN 182.A OD1 no hydrogen 3.587 N/A LEU 317.A N ASN 313.A O no hydrogen 2.895 N/A GLY 318.A N ARG 314.A O no hydrogen 3.296 N/A MET 319.A N ALA 315.A O no hydrogen 3.301 N/A GLU 320.A N ASN 316.A O no hydrogen 2.839 N/A VAL 321.A N LEU 317.A O no hydrogen 2.436 N/A MET 322.A N GLY 318.A O no hydrogen 3.260 N/A MET 322.A N MET 319.A O no hydrogen 3.248 N/A HIS 323.A N MET 319.A O no hydrogen 2.979 N/A HIS 323.A ND1 GLU 320.A O no hydrogen 2.426 N/A ASN 326.A ND2 GLU 56.A OE1 no hydrogen 3.046 N/A ALA 327.A N GLU 324.A O no hydrogen 3.005 N/A HIS 328.A ND1 GLU 324.A O no hydrogen 3.198 N/A HIS 328.A NE2 ASP 333.A OD2 no hydrogen 3.065 N/A