Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4lxh_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): MET 1.A N GLU 3.A OE1 no hydrogen 3.268 N/A MET 1.A N GLU 3.A OE2 no hydrogen 2.503 N/A GLU 3.A N GLU 3.A OE1 no hydrogen 2.859 N/A GLN 4.A N GLN 4.A OE1 no hydrogen 2.844 N/A PHE 5.A N PHE 2.A O no hydrogen 3.267 N/A SER 7.A OG HIS 18.A NE2 no hydrogen 2.695 N/A LYS 8.A N TYR 19.A O no hydrogen 2.860 N/A LYS 8.A NZ GLU 21.A OE2 no hydrogen 2.662 N/A ILE 10.A N THR 17.A O no hydrogen 3.204 N/A CYS 12.A N ILE 15.A O no hydrogen 2.710 N/A CYS 12.A SG THR 17.A OG1 no hydrogen 3.247 N/A GLY 14.A N ASP 11.A OD2 no hydrogen 3.355 N/A ILE 15.A N CYS 12.A O no hydrogen 2.818 N/A ARG 16.A N ASP 69.A OD2 no hydrogen 2.923 N/A THR 17.A N ILE 10.A O no hydrogen 2.881 N/A THR 17.A OG1 ILE 15.A O no hydrogen 3.058 N/A THR 17.A OG1 HIS 86.A NE2 no hydrogen 2.796 N/A HIS 18.A N THR 68.A OG1 no hydrogen 3.043 N/A HIS 18.A ND1 ASP 61.A OD2 no hydrogen 2.725 N/A HIS 18.A NE2 SER 7.A OG no hydrogen 2.695 N/A TYR 19.A N LYS 8.A O no hydrogen 2.946 N/A ILE 20.A N ALA 59.A O no hydrogen 2.890 N/A MET 22.A N VAL 57.A O no hydrogen 2.973 N/A LEU 28.A N ARG 56.A O no hydrogen 2.919 N/A VAL 29.A N CYS 100.A O no hydrogen 2.853 N/A LEU 30.A N ILE 58.A O no hydrogen 2.805 N/A VAL 31.A N ILE 102.A O no hydrogen 2.783 N/A HIS 32.A ND1 GLY 33.A O no hydrogen 2.707 N/A GLY 33.A N ASN 43.A OD1 no hydrogen 3.125 N/A ALA 38.A N GLY 35.A O no hydrogen 3.097 N/A GLY 40.A N ASP 61.A OD1 no hydrogen 2.903 N/A ARG 41.A NE TYR 179.A OH no hydrogen 3.216 N/A ARG 41.A NH2 TYR 179.A OH no hydrogen 3.338 N/A SER 42.A N ASP 39.A OD1 no hydrogen 2.720 N/A SER 42.A OG ASP 39.A O no hydrogen 3.178 N/A SER 42.A OG ASP 39.A OD1 no hydrogen 2.675 N/A ASN 43.A N ASP 39.A O no hydrogen 3.147 N/A PHE 44.A N GLY 40.A O no hydrogen 2.875 N/A ALA 45.A N ARG 41.A O no hydrogen 2.963 N/A ASN 47.A N PHE 44.A O no hydrogen 3.051 N/A ASN 47.A ND2 MET 258.A O no hydrogen 2.946 N/A PHE 48.A N PHE 44.A O no hydrogen 3.297 N/A PHE 51.A N ASN 47.A O no hydrogen 2.919 N/A ALA 52.A N PHE 48.A O no hydrogen 3.031 N/A ARG 53.A N ILE 50.A O no hydrogen 3.210 N/A HIS 54.A N PHE 51.A O no hydrogen 3.041 N/A MET 55.A N PHE 51.A O no hydrogen 2.877 N/A ARG 56.A N ASP 26.A O no hydrogen 2.917 N/A ARG 56.A NE GLU 21.A OE1 no hydrogen 2.718 N/A ARG 56.A NH2 GLU 21.A OE2 no hydrogen 3.372 N/A VAL 57.A N MET 22.A O no hydrogen 2.957 N/A ILE 58.A N LEU 28.A O no hydrogen 2.848 N/A ALA 59.A N ILE 20.A O no hydrogen 2.913 N/A ASP 61.A N HIS 18.A O no hydrogen 2.884 N/A MET 62.A N HIS 32.A NE2 no hydrogen 2.885 N/A VAL 63.A N HIS 86.A ND1 no hydrogen 3.198 N/A GLY 64.A N ASP 69.A O no hydrogen 3.350 N/A PHE 65.A N MET 62.A O no hydrogen 2.810 N/A GLN 67.A N ASP 61.A OD2 no hydrogen 3.184 N/A THR 68.A N PHE 65.A O no hydrogen 3.107 N/A THR 68.A OG1 ASP 61.A O no hydrogen 2.631 N/A ASP 69.A N ARG 16.A O no hydrogen 2.800 N/A ALA 74.A N ASP 72.A OD1 no hydrogen 3.047 N/A GLY 75.A N ASP 72.A O no hydrogen 3.045 N/A TYR 78.A OH PRO 71.A O no hydrogen 2.515 N/A GLN 80.A NE2 THR 84.A OG1 no hydrogen 3.177 N/A GLN 80.A NE2 THR 110.A OG1 no hydrogen 3.057 N/A ALA 82.A N THR 79.A OG1 no hydrogen 3.023 N/A ARG 83.A N THR 79.A O no hydrogen 3.224 N/A ARG 83.A NE GLN 80.A OE1 no hydrogen 2.977 N/A ARG 83.A NH2 GLN 80.A OE1 no hydrogen 2.894 N/A THR 84.A N GLN 80.A O no hydrogen 2.932 N/A THR 84.A OG1 GLN 80.A O no hydrogen 3.172 N/A ASP 85.A N ALA 81.A O no hydrogen 3.033 N/A HIS 86.A N ALA 82.A O no hydrogen 3.054 N/A HIS 86.A NE2 THR 17.A OG1 no hydrogen 2.796 N/A LEU 87.A N ARG 83.A O no hydrogen 2.915 N/A ILE 88.A N THR 84.A O no hydrogen 3.036 N/A SER 89.A N ASP 85.A O no hydrogen 2.898 N/A SER 89.A OG ASP 13.A OD2 no hydrogen 3.043 N/A PHE 90.A N HIS 86.A O no hydrogen 2.793 N/A ILE 91.A N LEU 87.A O no hydrogen 2.982 N/A LYS 92.A N ILE 88.A O no hydrogen 3.140 N/A ALA 93.A N SER 89.A O no hydrogen 2.667 N/A LEU 94.A N PHE 90.A O no hydrogen 2.979 N/A GLY 95.A N LYS 92.A O no hydrogen 2.876 N/A LEU 96.A N ILE 91.A O no hydrogen 3.205 N/A ILE 99.A N LEU 121.A O no hydrogen 2.801 N/A CYS 100.A N PRO 27.A O no hydrogen 3.034 N/A LEU 101.A N ARG 124.A O no hydrogen 2.894 N/A ILE 102.A N VAL 29.A O no hydrogen 2.972 N/A GLY 103.A N VAL 126.A O no hydrogen 3.035 N/A ASN 104.A N VAL 31.A O no hydrogen 3.121 N/A ASN 104.A ND2 ASN 43.A OD1 no hydrogen 3.461 N/A ALA 105.A N MET 128.A O no hydrogen 3.235 N/A GLY 108.A N ASN 104.A O no hydrogen 3.174 N/A THR 109.A N ALA 105.A O no hydrogen 2.961 N/A THR 109.A OG1 ALA 131.A O no hydrogen 2.323 N/A THR 110.A N MET 106.A O no hydrogen 3.052 N/A THR 110.A OG1 MET 106.A O no hydrogen 2.913 N/A ALA 111.A N GLY 107.A O no hydrogen 2.800 N/A CYS 112.A N GLY 108.A O no hydrogen 2.799 N/A GLY 113.A N THR 109.A O no hydrogen 2.918 N/A ALA 114.A N THR 110.A O no hydrogen 2.967 N/A ALA 115.A N ALA 111.A O no hydrogen 2.878 N/A LEU 116.A N CYS 112.A O no hydrogen 2.836 N/A LYS 117.A N GLY 113.A O no hydrogen 2.998 N/A LYS 117.A NZ ASP 85.A OD1 no hydrogen 2.650 N/A ALA 118.A N ALA 114.A O no hydrogen 2.737 N/A GLU 120.A N GLU 120.A OE1 no hydrogen 2.778 N/A LEU 121.A N ALA 118.A O no hydrogen 3.242 N/A ILE 122.A N PRO 119.A O no hydrogen 3.160 N/A ASP 123.A N ILE 99.A O no hydrogen 2.790 N/A ARG 124.A N ILE 99.A O no hydrogen 3.389 N/A LEU 125.A N PRO 218.A O no hydrogen 3.117 N/A VAL 126.A N LEU 101.A O no hydrogen 2.765 N/A LEU 127.A N LEU 220.A O no hydrogen 2.881 N/A MET 128.A N GLY 103.A O no hydrogen 2.937 N/A GLY 129.A N LEU 222.A O no hydrogen 3.017 N/A ALA 131.A N ALA 105.A O no hydrogen 3.070 N/A VAL 132.A N ALA 130.A O no hydrogen 2.877 N/A ASN 133.A ND2 LYS 234.A O no hydrogen 3.300 N/A ILE 134.A N LEU 205.A O no hydrogen 2.817 N/A SER 135.A N ASP 138.A OD2 no hydrogen 2.947 N/A SER 135.A OG ASP 138.A OD2 no hydrogen 2.944 N/A ASP 138.A N SER 135.A OG no hydrogen 3.005 N/A MET 139.A N SER 135.A O no hydrogen 2.965 N/A ALA 141.A N ASP 138.A O no hydrogen 3.290 N/A LEU 146.A N ARG 143.A O no hydrogen 2.868 N/A ALA 147.A N ASP 144.A O no hydrogen 3.136 N/A MET 150.A N LEU 146.A O no hydrogen 2.931 N/A SER 151.A N ALA 147.A O no hydrogen 3.121 N/A SER 151.A OG ALA 147.A O no hydrogen 2.435 N/A TYR 152.A OH SER 184.A OG no hydrogen 3.046 N/A SER 155.A N ASP 153.A OD1 no hydrogen 2.704 N/A SER 155.A OG ASP 153.A OD1 no hydrogen 2.378 N/A SER 155.A OG ASP 153.A OD2 no hydrogen 2.963 N/A SER 155.A OG GLU 157.A OE1 no hydrogen 3.021 N/A GLY 158.A N SER 155.A OG no hydrogen 3.112 N/A MET 159.A N SER 155.A O no hydrogen 2.906 N/A ARG 160.A N GLU 156.A O no hydrogen 3.018 N/A ARG 160.A NH2 ASP 174.A OD1 no hydrogen 2.981 N/A LYS 161.A N GLY 158.A O no hydrogen 3.063 N/A ILE 162.A N GLY 158.A O no hydrogen 3.136 N/A ILE 163.A N MET 159.A O no hydrogen 3.005 N/A ALA 164.A N ARG 160.A O no hydrogen 2.986 N/A ALA 165.A N LYS 161.A O no hydrogen 2.858 N/A LEU 166.A N ILE 162.A O no hydrogen 2.985 N/A THR 167.A OG1 ILE 163.A O no hydrogen 2.845 N/A HIS 168.A N GLU 260.A OE1 no hydrogen 2.884 N/A ILE 176.A N THR 173.A OG1 no hydrogen 3.306 N/A VAL 177.A N THR 173.A O no hydrogen 2.896 N/A HIS 178.A N ASP 174.A O no hydrogen 2.810 N/A TYR 179.A N ASP 175.A O no hydrogen 2.846 N/A TYR 179.A OH ASP 39.A OD2 no hydrogen 2.464 N/A ARG 180.A N ILE 176.A O no hydrogen 3.040 N/A HIS 181.A N VAL 177.A O no hydrogen 2.905 N/A HIS 181.A NE2 GLY 154.A O no hydrogen 2.759 N/A GLU 182.A N HIS 178.A O no hydrogen 2.960 N/A ALA 183.A N TYR 179.A O no hydrogen 2.927 N/A SER 184.A N ARG 180.A O no hydrogen 3.059 N/A SER 184.A N HIS 181.A O no hydrogen 3.226 N/A SER 184.A OG TYR 152.A OH no hydrogen 3.046 N/A SER 184.A OG HIS 181.A O no hydrogen 2.641 N/A LEU 185.A N GLU 182.A O no hydrogen 2.874 N/A ARG 186.A N ALA 183.A O no hydrogen 3.356 N/A ARG 186.A NH1 THR 189.A OG1 no hydrogen 2.927 N/A THR 189.A N ARG 186.A O no hydrogen 3.184 N/A THR 189.A OG1 ARG 186.A O no hydrogen 3.486 N/A THR 190.A N ARG 186.A O no hydrogen 3.096 N/A THR 190.A OG1 ARG 186.A O no hydrogen 3.112 N/A TYR 193.A N THR 189.A O no hydrogen 2.940 N/A LYS 194.A N THR 190.A O no hydrogen 3.010 N/A ALA 195.A N ALA 191.A O no hydrogen 3.047 N/A THR 196.A N ALA 192.A O no hydrogen 2.835 N/A THR 196.A OG1 ALA 192.A O no hydrogen 2.906 N/A MET 197.A N TYR 193.A O no hydrogen 2.953 N/A GLY 198.A N LYS 194.A O no hydrogen 3.030 N/A TRP 199.A N ALA 195.A O no hydrogen 2.974 N/A ALA 200.A N THR 196.A O no hydrogen 3.079 N/A LYS 201.A N MET 197.A O no hydrogen 2.814 N/A GLN 202.A N GLY 198.A O no hydrogen 3.158 N/A ASN 203.A N TRP 199.A O no hydrogen 2.825 N/A ASN 203.A ND2 TRP 199.A O no hydrogen 2.639 N/A LEU 205.A N ILE 134.A O no hydrogen 2.908 N/A TYR 207.A N VAL 132.A O no hydrogen 2.923 N/A TYR 207.A OH THR 109.A O no hydrogen 2.823 N/A SER 208.A N GLN 211.A OE1 no hydrogen 2.660 N/A SER 208.A OG GLN 211.A OE1 no hydrogen 3.243 N/A GLN 211.A N SER 208.A OG no hydrogen 2.717 N/A LEU 212.A N SER 208.A O no hydrogen 2.890 N/A ALA 213.A N PRO 209.A O no hydrogen 3.058 N/A SER 214.A N GLN 211.A O no hydrogen 2.786 N/A SER 214.A OG GLU 210.A O no hydrogen 3.381 N/A SER 214.A OG GLN 211.A O no hydrogen 2.182 N/A LEU 215.A N LEU 212.A O no hydrogen 3.253 N/A LEU 220.A N LEU 125.A O no hydrogen 2.911 N/A VAL 221.A N ILE 246.A O no hydrogen 2.827 N/A LEU 222.A N LEU 127.A O no hydrogen 2.944 N/A GLY 223.A N HIS 248.A O no hydrogen 3.055 N/A LYS 225.A N PHE 250.A O no hydrogen 2.824 N/A ASN 226.A N CYS 253.A O no hydrogen 2.856 N/A ASP 227.A N GLY 224.A O no hydrogen 3.336 N/A MET 229.A N ASP 227.A OD1 no hydrogen 2.749 N/A VAL 230.A N ASP 227.A OD1 no hydrogen 3.113 N/A LYS 234.A N PRO 231.A O no hydrogen 2.862 N/A LYS 234.A NZ ASN 133.A O no hydrogen 2.826 N/A LYS 234.A NZ ASP 138.A OD2 no hydrogen 2.656 N/A VAL 235.A N PRO 231.A O no hydrogen 3.329 N/A ILE 236.A N VAL 232.A O no hydrogen 2.816 N/A ASP 237.A N ARG 233.A O no hydrogen 2.945 N/A GLN 238.A N LYS 234.A O no hydrogen 3.074 N/A GLN 238.A NE2 ALA 130.A O no hydrogen 2.886 N/A GLN 238.A NE2 ASN 133.A OD1 no hydrogen 3.398 N/A ILE 239.A N VAL 235.A O no hydrogen 2.963 N/A LEU 240.A N ILE 236.A O no hydrogen 2.874 N/A ALA 241.A N ASP 237.A O no hydrogen 2.816 N/A ALA 241.A N GLN 238.A O no hydrogen 3.211 N/A ILE 242.A N GLN 238.A O no hydrogen 3.030 N/A GLN 244.A N GLN 244.A OE1 no hydrogen 2.639 N/A GLN 244.A NE2 LEU 215.A O no hydrogen 2.707 N/A GLN 244.A NE2 MET 217.A O no hydrogen 2.974 N/A ALA 245.A N ILE 242.A O no hydrogen 3.044 N/A ILE 246.A N VAL 219.A O no hydrogen 2.922 N/A HIS 248.A N VAL 221.A O no hydrogen 2.914 N/A PHE 250.A N GLY 223.A O no hydrogen 2.876 N/A CYS 253.A N ASN 226.A OD1 no hydrogen 3.110 N/A CYS 253.A SG GLY 254.A O no hydrogen 3.622 N/A GLY 254.A N GLU 260.A OE1 no hydrogen 2.947 N/A HIS 255.A N LEU 166.A O no hydrogen 2.746 N/A HIS 255.A ND1 ASP 227.A OD2 no hydrogen 2.511 N/A TRP 256.A N GLU 260.A OE2 no hydrogen 2.878 N/A ILE 259.A N TRP 256.A O no hydrogen 3.021 N/A GLU 260.A N TRP 256.A O no hydrogen 2.765 N/A TYR 261.A N VAL 257.A O no hydrogen 2.927 N/A TYR 261.A OH ASN 252.A O no hydrogen 2.632 N/A GLU 264.A N GLU 263.A OE1 no hydrogen 3.156 N/A PHE 265.A N TYR 261.A O no hydrogen 2.806 N/A CYS 266.A N PRO 262.A O no hydrogen 2.903 N/A CYS 266.A SG ASN 47.A O no hydrogen 3.976 N/A CYS 266.A SG PRO 262.A O no hydrogen 3.217 N/A THR 267.A N GLU 263.A O no hydrogen 2.852 N/A THR 267.A OG1 GLU 263.A O no hydrogen 3.107 N/A GLN 268.A N GLU 264.A O no hydrogen 3.019 N/A GLN 268.A NE2 GLU 264.A OE2 no hydrogen 2.771 N/A THR 269.A N PHE 265.A O no hydrogen 3.137 N/A THR 269.A OG1 PHE 265.A O no hydrogen 2.868 N/A THR 269.A OG1 CYS 266.A O no hydrogen 3.227 N/A LEU 270.A N CYS 266.A O no hydrogen 2.762 N/A HIS 271.A N THR 267.A O no hydrogen 2.915 N/A PHE 272.A N GLN 268.A O no hydrogen 3.061 N/A PHE 273.A N THR 269.A O no hydrogen 2.857 N/A GLY 274.A N HIS 271.A O no hydrogen 2.902 N/A LYS 275.A N LEU 270.A O no hydrogen 2.998 N/A LYS 275.A NZ ASP 26.A OD2 no hydrogen 3.277 N/A