Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4mkr_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 3.A N ILE 31.A O no hydrogen 3.154 N/A ASN 5.A N GLY 29.A O no hydrogen 3.004 N/A ASN 5.A ND2 GLU 101.A OE2 no hydrogen 3.469 N/A ASN 5.A ND2 TYR 103.A O no hydrogen 3.391 N/A LYS 6.A N GLU 102.A OE1 no hydrogen 2.716 N/A GLN 7.A N VAL 26.A O no hydrogen 3.168 N/A GLN 7.A NE2 GLU 101.A OE2 no hydrogen 2.841 N/A VAL 8.A N TRP 100.A O no hydrogen 2.849 N/A LEU 9.A N GLU 24.A O no hydrogen 2.890 N/A LEU 10.A N ALA 70.A O no hydrogen 3.157 N/A LYS 11.A N ASP 22.A O no hydrogen 2.966 N/A ILE 14.A N MET 59.A O no hydrogen 2.791 N/A LYS 19.A N ASP 22.A OD2 no hydrogen 2.754 N/A ASP 22.A N LYS 19.A O no hydrogen 2.854 N/A MET 23.A N GLU 20.A O no hydrogen 3.291 N/A GLU 24.A N LEU 9.A O no hydrogen 2.946 N/A VAL 26.A N GLN 7.A O no hydrogen 2.939 N/A THR 28.A OG1 THR 28.A O no hydrogen 2.538 N/A ILE 31.A N VAL 3.A O no hydrogen 3.000 N/A LEU 33.A N VAL 1.A O no hydrogen 3.240 N/A VAL 35.A N ASP 82.A OD2 no hydrogen 3.058 N/A SER 39.A N PRO 36.A O no hydrogen 3.219 N/A SER 39.A OG PRO 36.A O no hydrogen 2.918 N/A VAL 42.A N ILE 106.A O no hydrogen 3.209 N/A LEU 43.A N ASP 82.A O no hydrogen 2.888 N/A LEU 44.A N SER 104.A O no hydrogen 2.901 N/A LYS 45.A N LYS 79.A O no hydrogen 2.747 N/A ASN 46.A N GLU 102.A O no hydrogen 3.017 N/A ASN 46.A ND2 GLU 101.A O no hydrogen 2.914 N/A ASN 46.A ND2 SER 104.A OG no hydrogen 3.122 N/A LEU 47.A N VAL 77.A O no hydrogen 2.871 N/A TYR 48.A N VAL 77.A O no hydrogen 3.351 N/A LEU 49.A N VAL 324.A O no hydrogen 2.840 N/A SER 50.A N PHE 75.A O no hydrogen 2.989 N/A SER 50.A OG ASP 52.A OD1 no hydrogen 2.302 N/A SER 50.A OG ASP 52.A OD2 no hydrogen 2.887 N/A SER 50.A OG THR 126.A O no hydrogen 3.339 N/A CYS 51.A N GLN 322.A O no hydrogen 3.311 N/A MET 55.A N ASP 52.A O no hydrogen 3.001 N/A ARG 56.A N PRO 53.A O no hydrogen 3.269 N/A MET 57.A N TYR 54.A O no hydrogen 3.279 N/A ARG 58.A NE ASP 64.A O no hydrogen 2.821 N/A ARG 58.A NH1 THR 73.A OG1 no hydrogen 3.223 N/A ARG 58.A NH2 ASP 64.A O no hydrogen 3.225 N/A MET 59.A N ARG 56.A O no hydrogen 3.152 N/A THR 60.A N MET 57.A O no hydrogen 3.212 N/A THR 60.A OG1 ILE 14.A O no hydrogen 2.658 N/A PHE 66.A N ARG 58.A O no hydrogen 2.834 N/A GLY 69.A N LEU 10.A O no hydrogen 2.862 N/A ALA 70.A N VAL 67.A O no hydrogen 3.192 N/A ILE 72.A N VAL 8.A O no hydrogen 2.731 N/A GLY 74.A N ILE 98.A O no hydrogen 2.935 N/A GLY 76.A N GLY 96.A O no hydrogen 3.038 N/A VAL 77.A N TYR 48.A O no hydrogen 2.937 N/A GLY 78.A N VAL 94.A O no hydrogen 2.745 N/A LYS 79.A N LYS 45.A O no hydrogen 2.838 N/A VAL 80.A N ASP 92.A O no hydrogen 2.774 N/A VAL 81.A N LEU 43.A O no hydrogen 3.070 N/A SER 83.A OG PHE 88.A O no hydrogen 2.735 N/A SER 84.A N ALA 41.A O no hydrogen 3.055 N/A SER 84.A OG SER 39.A O no hydrogen 2.921 N/A SER 84.A OG ALA 41.A O no hydrogen 3.513 N/A HIS 85.A N SER 83.A OG no hydrogen 3.232 N/A ASP 87.A N HIS 85.A ND1 no hydrogen 3.191 N/A PHE 88.A N HIS 85.A O no hydrogen 3.426 N/A LYS 89.A N ASP 92.A OD2 no hydrogen 2.984 N/A LYS 89.A NZ ASP 92.A OD1 no hydrogen 2.840 N/A GLY 91.A N VAL 80.A O no hydrogen 2.734 N/A ASP 92.A N LYS 89.A O no hydrogen 3.059 N/A VAL 94.A N GLY 78.A O no hydrogen 2.895 N/A TRP 95.A N PHE 113.A O no hydrogen 3.018 N/A TRP 95.A NE1 TYR 277.A OH no hydrogen 3.203 N/A GLY 96.A N GLY 76.A O no hydrogen 3.090 N/A ILE 98.A N GLY 74.A O no hydrogen 2.926 N/A GLY 99.A N SER 104.A OG no hydrogen 3.130 N/A TRP 100.A N ILE 72.A O no hydrogen 2.541 N/A GLU 102.A N LYS 6.A O no hydrogen 3.314 N/A TYR 103.A N ASN 5.A OD1 no hydrogen 2.745 N/A SER 104.A N LEU 44.A O no hydrogen 3.088 N/A SER 104.A OG GLU 101.A OE1 no hydrogen 2.483 N/A ILE 106.A N VAL 42.A O no hydrogen 2.689 N/A GLN 110.A N GLN 110.A OE1 no hydrogen 2.953 N/A GLY 111.A N LYS 108.A O no hydrogen 3.067 N/A LEU 112.A N PRO 109.A O no hydrogen 2.945 N/A PHE 113.A N TRP 95.A O no hydrogen 2.817 N/A LYS 114.A NZ ASP 87.A O no hydrogen 3.404 N/A ILE 115.A N TYR 93.A O no hydrogen 2.935 N/A HIS 117.A ND1 GLU 119.A OE2 no hydrogen 2.675 N/A GLU 119.A N GLU 119.A OE1 no hydrogen 2.813 N/A ILE 120.A N HIS 117.A O no hydrogen 3.326 N/A SER 123.A OG GLU 297.A OE1 no hydrogen 3.352 N/A SER 123.A OG GLU 297.A OE2 no hydrogen 2.656 N/A TYR 124.A N PRO 121.A O no hydrogen 2.938 N/A TYR 125.A N LEU 122.A O no hydrogen 3.197 N/A TYR 125.A OH GLU 281.A OE2 no hydrogen 2.973 N/A THR 126.A N SER 123.A O no hydrogen 2.981 N/A THR 126.A OG1 SER 123.A O no hydrogen 2.656 N/A GLY 127.A N TYR 124.A O no hydrogen 2.971 N/A ILE 128.A N TYR 295.A OH no hydrogen 3.464 N/A LEU 129.A N TYR 124.A O no hydrogen 2.855 N/A GLY 130.A N GLY 127.A O no hydrogen 2.312 N/A GLY 133.A N GLY 127.A O no hydrogen 3.322 N/A LEU 134.A N GLY 130.A O no hydrogen 2.858 N/A THR 135.A N MET 131.A O no hydrogen 2.811 N/A THR 135.A OG1 MET 131.A O no hydrogen 2.756 N/A ALA 136.A N VAL 132.A O no hydrogen 3.181 N/A TYR 137.A N GLY 133.A O no hydrogen 3.076 N/A TYR 137.A OH GLU 279.A OE1 no hydrogen 2.800 N/A VAL 138.A N LEU 134.A O no hydrogen 3.128 N/A GLY 139.A N THR 135.A O no hydrogen 2.942 N/A PHE 140.A N ALA 136.A O no hydrogen 2.925 N/A TYR 141.A N TYR 137.A O no hydrogen 2.858 N/A ASP 142.A N VAL 138.A O no hydrogen 3.140 N/A ILE 143.A N VAL 138.A O no hydrogen 3.269 N/A CYS 144.A N GLY 139.A O no hydrogen 3.204 N/A CYS 144.A SG GLY 139.A O no hydrogen 3.217 N/A SER 145.A N ASP 142.A O no hydrogen 3.377 N/A LYS 147.A N GLU 150.A OE1 no hydrogen 2.958 N/A GLY 149.A N GLY 173.A O no hydrogen 2.845 N/A GLU 150.A N LYS 147.A O no hydrogen 3.236 N/A ARG 151.A N ASP 220.A OD2 no hydrogen 3.027 N/A ARG 151.A NH1 ASP 220.A OD2 no hydrogen 2.983 N/A VAL 152.A N TYR 175.A O no hydrogen 2.792 N/A PHE 153.A N ILE 221.A O no hydrogen 2.835 N/A VAL 154.A N VAL 177.A O no hydrogen 3.016 N/A SER 155.A N PHE 223.A O no hydrogen 3.442 N/A SER 155.A OG TYR 222.A OH no hydrogen 2.960 N/A SER 155.A OG PHE 223.A O no hydrogen 3.415 N/A GLY 159.A N ALA 156.A O no hydrogen 2.621 N/A GLN 163.A N GLY 159.A O no hydrogen 3.129 N/A GLN 163.A NE2 ALA 158.A O no hydrogen 2.828 N/A VAL 165.A N VAL 161.A O no hydrogen 2.906 N/A GLY 166.A N GLY 162.A O no hydrogen 2.942 N/A GLN 167.A NE2 GLN 163.A O no hydrogen 2.863 N/A GLN 167.A NE2 LYS 294.A O no hydrogen 3.382 N/A PHE 168.A N ILE 164.A O no hydrogen 2.966 N/A ALA 169.A N VAL 165.A O no hydrogen 2.851 N/A LYS 170.A N GLY 166.A O no hydrogen 2.757 N/A LYS 170.A NZ CYS 174.A O no hydrogen 3.007 N/A LYS 170.A NZ ASP 196.A OD1 no hydrogen 2.719 N/A LYS 170.A NZ ASP 196.A OD2 no hydrogen 2.471 N/A GLN 171.A N GLN 167.A O no hydrogen 2.889 N/A PHE 172.A N ALA 169.A O no hydrogen 3.132 N/A GLY 173.A N LYS 170.A O no hydrogen 2.936 N/A CYS 174.A N ALA 169.A O no hydrogen 2.963 N/A CYS 174.A SG LYS 147.A O no hydrogen 3.716 N/A TYR 175.A N GLU 150.A O no hydrogen 2.826 N/A TYR 175.A OH TYR 214.A O no hydrogen 3.189 N/A VAL 176.A N ASP 196.A OD2 no hydrogen 2.905 N/A VAL 177.A N VAL 152.A O no hydrogen 2.940 N/A GLY 178.A N GLU 197.A O no hydrogen 2.993 N/A SER 179.A N VAL 154.A O no hydrogen 2.932 N/A ALA 180.A N PHE 199.A O no hydrogen 3.051 N/A LYS 185.A N SER 182.A OG no hydrogen 3.265 N/A LYS 185.A NZ GLY 316.A O no hydrogen 3.385 N/A LYS 185.A NZ ASN 318.A O no hydrogen 2.619 N/A VAL 186.A N SER 182.A O no hydrogen 2.988 N/A ASN 187.A N ASP 183.A O no hydrogen 3.038 N/A LEU 188.A N GLU 184.A O no hydrogen 3.238 N/A LEU 189.A N LYS 185.A O no hydrogen 3.161 N/A LYS 190.A N VAL 186.A O no hydrogen 3.496 N/A THR 191.A N ASN 187.A O no hydrogen 2.760 N/A THR 191.A OG1 ASN 187.A O no hydrogen 3.172 N/A LYS 192.A N LEU 188.A O no hydrogen 2.633 N/A PHE 193.A N LEU 188.A O no hydrogen 3.047 N/A PHE 195.A N LEU 189.A O no hydrogen 2.799 N/A GLU 197.A N VAL 176.A O no hydrogen 3.251 N/A ALA 198.A N GLU 197.A OE1 no hydrogen 3.136 N/A PHE 199.A N GLY 178.A O no hydrogen 3.138 N/A ASN 200.A ND2 ASP 183.A OD1 no hydrogen 3.041 N/A TYR 201.A N ALA 180.A O no hydrogen 2.921 N/A LYS 202.A N ASN 200.A OD1 no hydrogen 2.979 N/A LYS 202.A NZ GLY 181.A O no hydrogen 3.462 N/A LYS 203.A N ASN 200.A O no hydrogen 3.039 N/A GLU 204.A N TYR 201.A O no hydrogen 3.426 N/A LYS 209.A N ASP 206.A OD1 no hydrogen 3.283 N/A ALA 210.A N ASP 206.A O no hydrogen 3.067 N/A LEU 211.A N LEU 207.A O no hydrogen 2.960 N/A LYS 212.A N THR 208.A O no hydrogen 3.060 N/A LYS 212.A NZ PRO 216.A O no hydrogen 3.034 N/A ARG 213.A N LYS 209.A O no hydrogen 3.036 N/A ARG 213.A NH1 GLU 204.A OE1 no hydrogen 2.843 N/A ARG 213.A NH2 GLU 204.A OE1 no hydrogen 3.520 N/A ARG 213.A NH2 GLU 204.A OE2 no hydrogen 2.766 N/A ARG 213.A NH2 TYR 214.A OH no hydrogen 3.171 N/A TYR 214.A N ALA 210.A O no hydrogen 3.272 N/A PHE 215.A N LEU 211.A O no hydrogen 2.895 N/A PHE 215.A N LYS 212.A O no hydrogen 3.218 N/A GLY 218.A N PHE 215.A O no hydrogen 2.939 N/A ILE 219.A N ASN 237.A O no hydrogen 2.733 N/A ASP 220.A N ARG 151.A O no hydrogen 3.051 N/A ILE 221.A N ARG 151.A O no hydrogen 2.976 N/A TYR 222.A N ARG 243.A O no hydrogen 2.854 N/A TYR 222.A OH SER 155.A OG no hydrogen 2.960 N/A TYR 222.A OH GLU 224.A OE2 no hydrogen 2.518 N/A PHE 223.A N PHE 153.A O no hydrogen 2.902 N/A GLU 224.A N ALA 245.A O no hydrogen 2.848 N/A ASN 225.A N SER 155.A OG no hydrogen 3.128 N/A ASN 225.A ND2 SER 155.A O no hydrogen 2.790 N/A VAL 226.A N GLU 224.A OE2 no hydrogen 2.886 N/A GLY 227.A N GLU 224.A OE2 no hydrogen 2.758 N/A GLU 232.A N GLY 228.A O no hydrogen 3.087 N/A ALA 233.A N PRO 229.A O no hydrogen 2.818 N/A VAL 234.A N MET 230.A O no hydrogen 2.936 N/A LEU 235.A N LEU 231.A O no hydrogen 2.917 N/A HIS 236.A N GLU 232.A O no hydrogen 3.083 N/A ASN 237.A N ALA 233.A O no hydrogen 3.267 N/A ASN 237.A ND2 THR 208.A O no hydrogen 2.975 N/A ASN 237.A ND2 ALA 233.A O no hydrogen 2.956 N/A MET 238.A N LEU 235.A O no hydrogen 3.284 N/A ARG 239.A N ILE 219.A O no hydrogen 2.687 N/A ARG 239.A NE GLU 217.A O no hydrogen 2.806 N/A ARG 239.A NH1 ASP 220.A OD1 no hydrogen 2.798 N/A LYS 241.A N LYS 261.A O no hydrogen 2.722 N/A GLY 242.A N ARG 239.A O no hydrogen 3.164 N/A ARG 243.A N ASP 220.A O no hydrogen 2.774 N/A ARG 243.A NE CYS 144.A O no hydrogen 3.051 N/A ARG 243.A NH1 LYS 241.A O no hydrogen 2.536 N/A ILE 244.A N ARG 264.A O no hydrogen 2.855 N/A ALA 245.A N TYR 222.A O no hydrogen 2.992 N/A ALA 246.A N GLU 266.A O no hydrogen 2.736 N/A CYS 247.A N GLU 224.A O no hydrogen 2.913 N/A CYS 247.A SG ASN 225.A OD1 no hydrogen 3.618 N/A GLY 248.A N GLU 224.A O no hydrogen 3.132 N/A HIS 253.A N GLU 232.A OE2 no hydrogen 3.210 N/A HIS 253.A ND1 GLU 232.A OE2 no hydrogen 2.929 N/A LEU 257.A N ASN 254.A O no hydrogen 3.123 N/A ILE 258.A N LEU 255.A O no hydrogen 2.765 N/A VAL 259.A N PHE 256.A O no hydrogen 2.996 N/A LYS 261.A N LEU 257.A O no hydrogen 3.005 N/A LYS 261.A NZ LEU 235.A O no hydrogen 2.851 N/A LYS 261.A NZ HIS 236.A O no hydrogen 3.019 N/A LYS 261.A NZ MET 238.A O no hydrogen 2.941 N/A ARG 262.A N VAL 259.A O no hydrogen 3.196 N/A ARG 262.A NE GLY 260.A O no hydrogen 3.360 N/A ARG 262.A NH2 GLY 260.A O no hydrogen 2.992 N/A ILE 263.A N ILE 258.A O no hydrogen 3.019 N/A ARG 264.A N GLY 242.A O no hydrogen 3.214 N/A ARG 264.A NH1 ILE 143.A O no hydrogen 2.861 N/A ARG 264.A NH1 GLU 266.A OE2 no hydrogen 2.851 N/A ARG 264.A NH2 ILE 143.A O no hydrogen 2.905 N/A GLU 266.A N ILE 244.A O no hydrogen 2.998 N/A PHE 268.A N ALA 246.A O no hydrogen 3.210 N/A ASP 272.A N LEU 269.A O no hydrogen 3.146 N/A HIS 273.A N VAL 270.A O no hydrogen 2.781 N/A SER 276.A N HIS 273.A O no hydrogen 2.918 N/A TYR 277.A N TYR 274.A O no hydrogen 2.953 N/A TYR 277.A OH LEU 129.A O no hydrogen 3.258 N/A PHE 280.A N SER 276.A O no hydrogen 3.106 N/A GLU 281.A N TYR 277.A O no hydrogen 2.797 N/A GLU 282.A N PRO 278.A O no hydrogen 3.199 N/A LYS 283.A N GLU 279.A O no hydrogen 3.002 N/A VAL 284.A N PHE 280.A O no hydrogen 3.055 N/A VAL 285.A N GLU 281.A O no hydrogen 2.956 N/A GLN 286.A N GLU 282.A O no hydrogen 3.191 N/A GLN 286.A NE2 GLU 290.A OE2 no hydrogen 3.155 N/A LEU 287.A N LYS 283.A O no hydrogen 2.961 N/A ILE 288.A N VAL 284.A O no hydrogen 2.990 N/A LYS 289.A N VAL 285.A O no hydrogen 2.852 N/A LYS 289.A NZ GLU 119.A OE2 no hydrogen 2.996 N/A GLU 290.A N GLN 286.A O no hydrogen 2.785 N/A GLU 291.A N ILE 288.A O no hydrogen 3.239 N/A LYS 292.A N LEU 287.A O no hydrogen 2.792 N/A LYS 294.A N GLN 167.A OE1 no hydrogen 2.857 N/A ASP 298.A N LYS 321.A O no hydrogen 2.649 N/A VAL 300.A N VAL 323.A O no hydrogen 2.908 N/A GLY 302.A N VAL 325.A O no hydrogen 2.822 N/A ASN 305.A N GLY 302.A O no hydrogen 2.994 N/A ASN 305.A ND2 GLU 301.A O no hydrogen 2.788 N/A ALA 306.A N LEU 303.A O no hydrogen 2.819 N/A ALA 309.A N ASN 305.A O no hydrogen 2.992 N/A LEU 310.A N ALA 306.A O no hydrogen 2.924 N/A ILE 311.A N PRO 307.A O no hydrogen 3.130 N/A GLY 312.A N ALA 308.A O no hydrogen 2.792 N/A LEU 313.A N ALA 309.A O no hydrogen 2.875 N/A PHE 314.A N LEU 310.A O no hydrogen 2.954 N/A GLU 315.A N ILE 311.A O no hydrogen 3.058 N/A GLU 315.A N GLY 312.A O no hydrogen 3.174 N/A GLY 316.A N LEU 313.A O no hydrogen 2.793 N/A ARG 317.A N GLY 312.A O no hydrogen 3.052 N/A ASN 318.A ND2 GLY 320.A O no hydrogen 3.171 N/A VAL 319.A N ASP 298.A OD2 no hydrogen 3.057 N/A LYS 321.A N LEU 296.A O no hydrogen 3.179 N/A LYS 321.A NZ SER 50.A OG no hydrogen 2.369 N/A LYS 321.A NZ ASP 52.A OD1 no hydrogen 2.591 N/A LYS 321.A NZ GLN 322.A O no hydrogen 3.171 N/A GLN 322.A NE2 ASP 298.A OD1 no hydrogen 3.330 N/A VAL 323.A N ASP 298.A O no hydrogen 2.752 N/A VAL 324.A N LEU 49.A O no hydrogen 2.680 N/A VAL 325.A N VAL 300.A O no hydrogen 2.895 N/A VAL 326.A N LEU 47.A O no hydrogen 2.709 N/A SER 327.A N LEU 47.A O no hydrogen 3.408 N/A