Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4n2x_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 2.A OG LEU 4.A O no hydrogen 3.393 N/A GLN 9.A NE2 PHE 7.A O no hydrogen 2.796 N/A VAL 10.A N ARG 40.A O no hydrogen 2.816 N/A ASP 11.A N GLN 14.A OE1 no hydrogen 2.849 N/A GLN 14.A N ASP 11.A O no hydrogen 2.832 N/A ALA 20.A N LYS 16.A O no hydrogen 3.104 N/A GLU 21.A N GLY 17.A O no hydrogen 3.106 N/A VAL 22.A N GLN 18.A O no hydrogen 2.937 N/A TYR 23.A N LEU 19.A O no hydrogen 2.849 N/A TYR 23.A OH VAL 10.A O no hydrogen 2.641 N/A ASP 24.A N ALA 20.A O no hydrogen 2.862 N/A ASP 25.A N GLU 21.A O no hydrogen 2.802 N/A ILE 26.A N VAL 22.A O no hydrogen 2.681 N/A HIS 27.A N TYR 23.A O no hydrogen 2.955 N/A HIS 27.A ND1 VAL 32.A O no hydrogen 2.763 N/A ASN 28.A N ASP 24.A O no hydrogen 2.787 N/A THR 29.A N ASP 25.A O no hydrogen 2.648 N/A THR 29.A OG1 ASP 25.A O no hydrogen 2.839 N/A THR 29.A OG1 ASP 25.A OD1 no hydrogen 2.874 N/A MET 30.A N ILE 26.A O no hydrogen 2.874 N/A ARG 31.A NE GLY 152.A O no hydrogen 2.914 N/A ARG 31.A NH1 THR 297.A OG1 no hydrogen 2.761 N/A VAL 32.A N HIS 27.A O no hydrogen 2.944 N/A VAL 35.A N HIS 12.A NE2 no hydrogen 2.722 N/A ALA 36.A N TYR 117.A OH no hydrogen 3.125 N/A ARG 40.A N ALA 36.A O no hydrogen 2.994 N/A ARG 40.A NE GLN 9.A OE1 no hydrogen 2.742 N/A ARG 40.A NH1 VAL 35.A O no hydrogen 2.675 N/A ARG 40.A NH1 SER 190.A OG no hydrogen 2.780 N/A ARG 40.A NH2 GLN 9.A OE1 no hydrogen 2.808 N/A VAL 41.A N PHE 37.A O no hydrogen 2.752 N/A MET 42.A N GLY 38.A O no hydrogen 2.748 N/A SER 43.A N ILE 39.A O no hydrogen 2.740 N/A SER 43.A OG ILE 39.A O no hydrogen 2.624 N/A GLN 44.A N VAL 41.A O no hydrogen 3.159 N/A PHE 45.A N MET 42.A O no hydrogen 3.085 N/A PHE 48.A N PRO 46.A O no hydrogen 2.675 N/A ASP 51.A N HIS 47.A O no hydrogen 2.772 N/A ALA 52.A N PHE 48.A O no hydrogen 2.706 N/A TRP 53.A N ILE 49.A O no hydrogen 2.755 N/A TRP 53.A NE1 ASP 25.A OD2 no hydrogen 2.882 N/A ALA 54.A N PRO 50.A O no hydrogen 2.942 N/A ALA 55.A N ASP 51.A O no hydrogen 3.172 N/A LEU 56.A N ALA 52.A O no hydrogen 2.874 N/A LYS 57.A N TRP 53.A O no hydrogen 2.788 N/A LYS 57.A NZ ASP 25.A OD1 no hydrogen 3.105 N/A LYS 57.A NZ ASP 25.A OD2 no hydrogen 2.713 N/A ASN 59.A N LEU 56.A O no hydrogen 2.634 N/A ASN 59.A ND2 ALA 55.A O no hydrogen 2.891 N/A ASN 59.A ND2 PRO 240.A O no hydrogen 3.328 N/A ILE 60.A N LEU 56.A O no hydrogen 2.732 N/A GLU 61.A N LYS 57.A O no hydrogen 2.964 N/A THR 62.A OG1 ASN 59.A O no hydrogen 3.240 N/A ARG 63.A N GLU 147.A O no hydrogen 2.741 N/A ARG 63.A NH1 ASP 67.A OD1 no hydrogen 2.889 N/A ARG 63.A NH2 THR 297.A O no hydrogen 2.710 N/A TYR 64.A N ASP 145.A O no hydrogen 2.831 N/A TYR 64.A OH HIS 233.A O no hydrogen 2.611 N/A ALA 65.A N THR 62.A OG1 no hydrogen 2.960 N/A GLU 66.A N THR 62.A O no hydrogen 2.942 N/A ASP 67.A N ARG 63.A O no hydrogen 2.728 N/A GLY 68.A N TYR 64.A O no hydrogen 2.996 N/A ALA 69.A N ALA 65.A O no hydrogen 2.913 N/A ASP 70.A N GLU 66.A O no hydrogen 2.788 N/A LEU 71.A N ASP 67.A O no hydrogen 2.814 N/A ILE 72.A N GLY 68.A O no hydrogen 2.888 N/A ARG 73.A N ALA 69.A O no hydrogen 2.760 N/A ARG 73.A NE ASN 111.A O no hydrogen 2.719 N/A ARG 73.A NH1 ASP 70.A OD1 no hydrogen 2.782 N/A ARG 73.A NH2 TYR 112.A O no hydrogen 2.820 N/A LEU 74.A N ASP 70.A O no hydrogen 2.771 N/A ASN 75.A N LEU 71.A O no hydrogen 3.144 N/A ASN 75.A N ILE 72.A O no hydrogen 2.964 N/A ASN 75.A ND2 LEU 71.A O no hydrogen 2.828 N/A SER 76.A N ARG 73.A O no hydrogen 3.138 N/A SER 76.A OG ILE 72.A O no hydrogen 2.684 N/A GLY 80.A N VAL 78.A O no hydrogen 2.761 N/A THR 87.A N ASN 85.A OD1 no hydrogen 2.765 N/A THR 87.A OG1 ASN 85.A OD1 no hydrogen 2.724 N/A LYS 89.A NZ.A ASP 208.A OD1 no hydrogen 3.315 N/A LYS 89.A NZ.A ASP 208.A OD2 no hydrogen 2.622 N/A LYS 89.A NZ.B ASN 85.A O no hydrogen 3.382 N/A LEU 90.A N PRO 86.A O no hydrogen 2.906 N/A LEU 91.A N THR 87.A O no hydrogen 2.799 N/A ARG 92.A N PRO 88.A O no hydrogen 2.867 N/A LEU 93.A N LYS 89.A O no hydrogen 2.960 N/A GLY 94.A N LEU 91.A O no hydrogen 2.803 N/A TRP 95.A N LEU 90.A O no hydrogen 2.940 N/A TRP 95.A NE1 ASP 200.A OD2 no hydrogen 2.866 N/A LYS 99.A N THR 96.A OG1 no hydrogen 2.905 N/A ILE 100.A N THR 96.A O no hydrogen 2.934 N/A GLU 101.A N GLU 97.A O no hydrogen 2.852 N/A GLU 102.A N SER 98.A O no hydrogen 2.861 N/A LEU 103.A N LYS 99.A O no hydrogen 2.938 N/A LYS 104.A N ILE 100.A O no hydrogen 2.796 N/A LYS 104.A NZ GLU 101.A OE2 no hydrogen 2.976 N/A THR 105.A N GLU 101.A O no hydrogen 2.844 N/A THR 105.A OG1 GLU 101.A O no hydrogen 2.964 N/A ALA 106.A N GLU 102.A O no hydrogen 2.872 N/A LEU 107.A N LEU 103.A O no hydrogen 2.856 N/A ASP 108.A N LYS 104.A O no hydrogen 2.809 N/A LEU 109.A N THR 105.A O no hydrogen 2.846 N/A LEU 110.A N ALA 106.A O no hydrogen 2.948 N/A ASN 111.A N LEU 107.A O no hydrogen 2.684 N/A ASN 111.A ND2 ILE 278.A O no hydrogen 3.081 N/A TYR 112.A N ASP 108.A O no hydrogen 2.820 N/A TYR 112.A OH GLU 66.A OE2 no hydrogen 2.459 N/A GLY 113.A N LEU 109.A O no hydrogen 2.994 N/A ASN 114.A N LEU 110.A O no hydrogen 2.743 N/A ASN 114.A ND2 ASP 191.A OD1 no hydrogen 2.708 N/A LYS 116.A NZ MET 30.A O no hydrogen 2.807 N/A LYS 116.A NZ GLU 66.A OE1 no hydrogen 2.748 N/A TYR 117.A N GLY 113.A O no hydrogen 2.802 N/A TYR 117.A OH TRP 34.A O no hydrogen 2.534 N/A LEU 118.A N ASN 114.A O no hydrogen 2.846 N/A ILE 119.A N PRO 115.A O no hydrogen 3.095 N/A LEU 120.A N LYS 116.A O no hydrogen 2.862 N/A ILE 121.A N TYR 117.A O no hydrogen 2.751 N/A THR 122.A N LEU 118.A O no hydrogen 2.908 N/A THR 122.A OG1 LEU 118.A O no hydrogen 2.632 N/A THR 122.A OG1 ASN 268.A OD1 no hydrogen 3.408 N/A ALA 123.A N ILE 119.A O no hydrogen 2.846 N/A PHE 124.A N LEU 120.A O no hydrogen 2.877 N/A ASN 125.A N ILE 121.A O no hydrogen 2.738 N/A ASN 125.A ND2 GLU 126.A OE2 no hydrogen 2.860 N/A GLU 126.A N THR 122.A O no hydrogen 2.816 N/A ALA 127.A N ALA 123.A O no hydrogen 2.850 N/A TRP 128.A N PHE 124.A O no hydrogen 3.001 N/A TRP 128.A NE1 THR 261.A OG1 no hydrogen 2.783 N/A HIS 129.A N ASN 125.A O no hydrogen 3.341 N/A HIS 129.A N GLU 126.A O no hydrogen 3.092 N/A GLU 130.A N ALA 127.A O no hydrogen 2.825 N/A ARG 131.A N GLU 126.A O no hydrogen 2.881 N/A ARG 131.A NE GLU 126.A OE1 no hydrogen 2.649 N/A ARG 131.A NH2 GLU 126.A OE2 no hydrogen 2.941 N/A GLY 134.A N ASP 132.A OD1 no hydrogen 2.934 N/A GLY 135.A N PHE 237.A O no hydrogen 2.850 N/A ARG 136.A NH2 GLU 130.A O no hydrogen 2.802 N/A LYS 140.A NZ ASP 238.A O no hydrogen 2.867 N/A LEU 141.A N ASP 238.A OD1 no hydrogen 2.732 N/A ARG 144.A NE GLU 147.A OE1 no hydrogen 3.299 N/A ARG 144.A NE GLU 147.A OE2 no hydrogen 2.730 N/A ARG 144.A NH2 GLU 147.A OE1 no hydrogen 2.727 N/A ARG 144.A NH2 GLU 147.A OE2 no hydrogen 3.400 N/A ASP 145.A N ARG 142.A O no hydrogen 3.027 N/A GLU 147.A N ARG 144.A O no hydrogen 2.923 N/A ILE 149.A N GLU 61.A O no hydrogen 2.822 N/A TYR 151.A OH ASP 25.A OD1 no hydrogen 2.629 N/A GLY 152.A N ASN 28.A O no hydrogen 2.723 N/A SER 156.A OG ASN 155.A O no hydrogen 2.499 N/A VAL 157.A N PRO 154.A O no hydrogen 2.941 N/A LYS 159.A NZ ASP 24.A OD1 no hydrogen 2.984 N/A PHE 160.A N PRO 33.A O no hydrogen 2.821 N/A LEU 163.A N ARG 193.A O no hydrogen 2.744 N/A LYS 167.A N ASP 164.A O no hydrogen 3.069 N/A LYS 167.A N ASP 164.A OD1 no hydrogen 3.259 N/A ALA 168.A N ILE 165.A O no hydrogen 2.968 N/A SER 169.A OG THR 172.A OG1 no hydrogen 3.239 N/A ARG 171.A NE GLU 203.A OE1 no hydrogen 3.419 N/A ARG 171.A NE GLU 203.A OE2 no hydrogen 2.764 N/A ARG 171.A NH2 GLU 203.A OE1 no hydrogen 2.810 N/A THR 172.A N SER 169.A OG no hydrogen 2.902 N/A THR 172.A OG1 SER 169.A OG no hydrogen 3.239 N/A THR 172.A OG1 GLY 196.A O no hydrogen 2.929 N/A GLN 173.A N SER 169.A O no hydrogen 2.801 N/A GLN 173.A NE2 ILE 165.A O no hydrogen 2.793 N/A THR 174.A N ASP 170.A O no hydrogen 2.682 N/A THR 174.A OG1 ASP 170.A O no hydrogen 2.753 N/A VAL 175.A N ARG 171.A O no hydrogen 3.000 N/A LEU 176.A N THR 172.A O no hydrogen 2.949 N/A ARG 177.A N GLN 173.A O no hydrogen 2.792 N/A ARG 177.A NE ASP 178.A OD1 no hydrogen 2.635 N/A ARG 177.A NH2 ASP 178.A OD1 no hydrogen 2.854 N/A ASP 178.A N THR 174.A O no hydrogen 2.761 N/A ILE 179.A N VAL 175.A O no hydrogen 2.784 N/A ARG 180.A N LEU 176.A O no hydrogen 2.776 N/A ARG 180.A NE ASP 181.A OD1 no hydrogen 2.804 N/A ARG 180.A NH2 ASP 181.A OD1 no hydrogen 2.989 N/A ARG 180.A NH2 ASP 181.A OD2 no hydrogen 3.218 N/A ASP 181.A N ARG 177.A O no hydrogen 2.803 N/A ALA 182.A N ASP 178.A O no hydrogen 2.814 N/A PHE 183.A N ARG 180.A O no hydrogen 3.285 N/A LEU 184.A N ASP 181.A O no hydrogen 2.963 N/A HIS 185.A N ARG 180.A O no hydrogen 2.821 N/A HIS 185.A NE2 ASP 273.A OD2 no hydrogen 2.825 N/A HIS 186.A N HIS 186.A ND1 no hydrogen 2.856 N/A HIS 186.A NE2 TYR 267.A OH no hydrogen 2.603 N/A TYR 192.A N ALA 189.A O no hydrogen 2.857 N/A ARG 193.A N ALA 189.A O no hydrogen 3.261 N/A ARG 193.A NE LEU 163.A O no hydrogen 2.794 N/A ARG 193.A NH1 GLN 9.A OE1 no hydrogen 3.300 N/A ARG 193.A NH1 ASP 11.A OD1 no hydrogen 2.983 N/A ARG 193.A NH2 ASP 11.A OD1 no hydrogen 2.999 N/A ARG 193.A NH2 LEU 163.A O no hydrogen 2.938 N/A VAL 194.A N SER 190.A O no hydrogen 2.889 N/A VAL 194.A N ASP 191.A O no hydrogen 3.178 N/A LEU 195.A N ASP 191.A O no hydrogen 2.768 N/A TRP 198.A N LEU 195.A O no hydrogen 2.736 N/A TYR 201.A N ASP 200.A OD1 no hydrogen 2.899 N/A LEU 202.A N TRP 198.A O no hydrogen 2.930 N/A GLU 203.A N PRO 199.A O no hydrogen 2.846 N/A ILE 204.A N ASP 200.A O no hydrogen 3.287 N/A ALA 205.A N TYR 201.A O no hydrogen 2.726 N/A LEU 206.A N LEU 202.A O no hydrogen 2.717 N/A ARG 207.A N GLU 203.A O no hydrogen 2.976 N/A ASP 208.A N ILE 204.A O no hydrogen 2.722 N/A SER 209.A N ALA 205.A O no hydrogen 2.798 N/A LEU 210.A N ALA 205.A O no hydrogen 2.899 N/A LEU 210.A N LEU 206.A O no hydrogen 3.301 N/A ALA 211.A N LEU 206.A O no hydrogen 2.671 N/A VAL 213.A N LEU 210.A O no hydrogen 3.044 N/A ALA 214.A N LEU 210.A O no hydrogen 2.912 N/A SER 216.A N VAL 213.A O no hydrogen 2.995 N/A SER 216.A OG VAL 213.A O no hydrogen 2.621 N/A SER 216.A OG GLU 218.A OE1 no hydrogen 3.492 N/A TYR 219.A N SER 216.A OG no hydrogen 3.008 N/A TYR 219.A OH ASP 273.A O no hydrogen 2.588 N/A ASP 220.A N SER 216.A O no hydrogen 2.906 N/A GLU 221.A N ALA 217.A O no hydrogen 2.728 N/A THR 222.A N GLU 218.A O no hydrogen 3.063 N/A THR 222.A OG1 GLU 218.A O no hydrogen 2.808 N/A ALA 223.A N TYR 219.A O no hydrogen 2.812 N/A ARG 224.A N ASP 220.A O no hydrogen 2.774 N/A ARG 224.A NE GLU 221.A OE1 no hydrogen 2.725 N/A ARG 224.A NE GLU 221.A OE2 no hydrogen 3.410 N/A ARG 224.A NH2 GLU 221.A OE1 no hydrogen 3.542 N/A ARG 224.A NH2 GLU 221.A OE2 no hydrogen 2.675 N/A ARG 225.A N GLU 221.A O no hydrogen 2.816 N/A ARG 225.A NE ASN 75.A O no hydrogen 2.905 N/A ARG 225.A NH2 ASN 75.A O no hydrogen 3.149 N/A ARG 225.A NH2 THR 222.A OG1 no hydrogen 3.228 N/A ILE 226.A N THR 222.A O no hydrogen 2.855 N/A ARG 227.A N ALA 223.A O no hydrogen 2.788 N/A LYS 228.A N ARG 224.A O no hydrogen 2.885 N/A ILE 229.A N ARG 225.A O no hydrogen 2.942 N/A ALA 230.A N ILE 226.A O no hydrogen 2.891 N/A ARG 231.A N ARG 227.A O no hydrogen 2.869 N/A GLU 232.A N LYS 228.A O no hydrogen 2.839 N/A HIS 233.A N ILE 229.A O no hydrogen 2.854 N/A HIS 233.A NE2 TYR 64.A O no hydrogen 2.654 N/A VAL 234.A N ALA 230.A O no hydrogen 3.101 N/A LYS 235.A N GLU 232.A O no hydrogen 3.079 N/A LYS 235.A NZ GLU 232.A OE1.B no hydrogen 3.232 N/A GLY 236.A N HIS 233.A O no hydrogen 2.914 N/A PHE 237.A N VAL 234.A O no hydrogen 3.085 N/A ALA 241.A N THR 133.A OG1 no hydrogen 2.787 N/A TRP 245.A N TRP 128.A O no hydrogen 2.976 N/A ARG 246.A NH1 GLU 130.A OE1 no hydrogen 3.373 N/A ARG 246.A NH1 GLU 130.A OE2 no hydrogen 2.953 N/A ASP 247.A N ALA 244.A O no hydrogen 2.896 N/A MET 248.A N TRP 245.A O no hydrogen 2.754 N/A THR 249.A OG1 GLU 250.A OE1 no hydrogen 3.233 N/A LYS 251.A N MET 248.A O no hydrogen 2.952 N/A LYS 251.A NZ ASP 51.A OD2 no hydrogen 2.536 N/A LEU 252.A N MET 248.A O no hydrogen 2.857 N/A SER 253.A N GLN 256.A OE1 no hydrogen 2.862 N/A GLN 256.A N SER 253.A OG no hydrogen 3.049 N/A ILE 257.A N SER 253.A O no hydrogen 2.733 N/A ALA 258.A N ALA 254.A O no hydrogen 2.818 N/A GLY 259.A N GLU 255.A O no hydrogen 2.804 N/A LEU 260.A N GLN 256.A O no hydrogen 2.819 N/A THR 261.A N ILE 257.A O no hydrogen 2.897 N/A THR 261.A OG1 ILE 257.A O no hydrogen 2.628 N/A GLY 262.A N ALA 258.A O no hydrogen 3.062 N/A LEU 263.A N GLY 259.A O no hydrogen 2.854 N/A LEU 264.A N LEU 260.A O no hydrogen 2.715 N/A PHE 265.A N THR 261.A O no hydrogen 3.019 N/A MET 266.A N GLY 262.A O no hydrogen 2.766 N/A TYR 267.A N LEU 263.A O no hydrogen 2.761 N/A ASN 268.A N LEU 264.A O no hydrogen 2.832 N/A ARG 269.A N PHE 265.A O no hydrogen 3.087 N/A PHE 270.A N MET 266.A O no hydrogen 2.744 N/A ILE 271.A N TYR 267.A O no hydrogen 2.868 N/A ASP 273.A N ARG 269.A O no hydrogen 2.923 N/A ILE 274.A N PHE 270.A O no hydrogen 2.758 N/A THR 275.A N ILE 271.A O no hydrogen 2.730 N/A THR 275.A OG1 ILE 271.A O no hydrogen 2.614 N/A ILE 276.A N ALA 272.A O no hydrogen 3.092 N/A ALA 277.A N ASP 273.A O no hydrogen 2.901 N/A ILE 278.A N ILE 274.A O no hydrogen 2.974 N/A ILE 279.A N THR 275.A O no hydrogen 3.184 N/A ARG 280.A N ILE 276.A O no hydrogen 2.851 N/A ARG 280.A NE SER 209.A O no hydrogen 2.737 N/A ARG 280.A NH2 PRO 81.A O no hydrogen 2.919 N/A LEU 281.A N ALA 277.A O no hydrogen 2.909 N/A LYS 282.A N ILE 278.A O no hydrogen 2.959 N/A LYS 282.A NZ ASP 108.A OD1 no hydrogen 2.712 N/A LYS 282.A NZ ASP 108.A OD2 no hydrogen 3.487 N/A LYS 282.A NZ ASP 290.A OD2 no hydrogen 2.764 N/A GLN 283.A N ILE 279.A O no hydrogen 2.767 N/A ALA 284.A N ARG 280.A O no hydrogen 3.087 N/A ALA 284.A N LEU 281.A O no hydrogen 3.166 N/A SER 286.A N LYS 282.A O no hydrogen 2.818 N/A SER 286.A OG LYS 282.A O no hydrogen 3.039 N/A SER 286.A OG GLY 287.A O no hydrogen 3.353 N/A SER 286.A OG ASP 290.A OD2 no hydrogen 2.581 N/A GLY 287.A N SER 286.A OG no hydrogen 2.707 N/A ALA 291.A N GLY 287.A O no hydrogen 2.936 N/A THR 292.A N PRO 288.A O no hydrogen 2.928 N/A THR 292.A N GLU 289.A O no hydrogen 3.359 N/A THR 292.A OG1 PRO 288.A O no hydrogen 2.624 N/A ALA 293.A N ASP 290.A O no hydrogen 3.242 N/A ASN 294.A ND2 GLU 66.A OE2 no hydrogen 3.191 N/A ASN 294.A ND2 ASP 70.A OD1 no hydrogen 2.750 N/A LYS 295.A NZ ASP 108.A OD1 no hydrogen 3.568 N/A LYS 295.A NZ ASP 108.A OD2 no hydrogen 2.957 N/A LYS 295.A NZ ASP 290.A OD1 no hydrogen 2.825 N/A TYR 296.A N ASN 294.A OD1 no hydrogen 2.931 N/A THR 297.A N ASN 294.A OD1 no hydrogen 2.828 N/A THR 297.A OG1 TYR 112.A OH no hydrogen 2.735 N/A ASN 298.A ND2 ASN 294.A O no hydrogen 2.869 N/A