Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4op4_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 3.A OG GLU 248.A OE2 no hydrogen 2.723 N/A ALA 7.A N SER 3.A O no hydrogen 2.903 N/A LEU 8.A N PRO 4.A O no hydrogen 3.007 N/A ALA 9.A N VAL 5.A O no hydrogen 2.999 N/A LYS 10.A N LEU 6.A O no hydrogen 2.882 N/A LYS 10.A NZ ASP 2.A OD2 no hydrogen 2.821 N/A GLU 11.A N ALA 7.A O no hydrogen 3.146 N/A LEU 12.A N LEU 8.A O no hydrogen 2.993 N/A ILE 13.A N ALA 9.A O no hydrogen 2.917 N/A SER 14.A N LYS 10.A O no hydrogen 3.161 N/A SER 14.A OG GLU 11.A O no hydrogen 2.739 N/A ARG 15.A N LEU 12.A O no hydrogen 2.986 N/A ARG 15.A NH1 ALA 23.A O no hydrogen 3.510 N/A SER 17.A N ARG 15.A O no hydrogen 2.802 N/A SER 17.A OG ARG 15.A O no hydrogen 3.402 N/A SER 17.A OG THR 68.A O no hydrogen 2.956 N/A THR 19.A N VAL 70.A O no hydrogen 3.147 N/A THR 19.A OG1 ASP 69.A OD2 no hydrogen 2.393 N/A THR 19.A OG1 VAL 70.A O no hydrogen 3.269 N/A ALA 21.A N VAL 18.A O no hydrogen 2.680 N/A CYS 25.A N ASP 22.A O no hydrogen 3.201 N/A CYS 25.A SG LEU 12.A O no hydrogen 3.876 N/A CYS 25.A SG ASP 22.A O no hydrogen 3.533 N/A GLN 26.A N ASP 22.A OD2 no hydrogen 3.071 N/A GLN 26.A NE2 THR 49.A O no hydrogen 3.039 N/A GLN 26.A NE2 THR 68.A OG1 no hydrogen 2.987 N/A LEU 28.A N GLY 24.A O no hydrogen 3.309 N/A MET 29.A N CYS 25.A O no hydrogen 3.143 N/A ILE 30.A N GLN 26.A O no hydrogen 2.737 N/A GLU 31.A N ASP 27.A O no hydrogen 3.009 N/A ARG 32.A N LEU 28.A O no hydrogen 3.346 N/A ARG 32.A NE GLU 113.A OE2 no hydrogen 2.555 N/A ARG 32.A NH1 GLU 113.A OE1 no hydrogen 2.932 N/A ARG 32.A NH1 GLU 113.A OE2 no hydrogen 3.414 N/A LEU 33.A N MET 29.A O no hydrogen 3.074 N/A LYS 34.A N ILE 30.A O no hydrogen 2.892 N/A ALA 35.A N GLU 31.A O no hydrogen 3.416 N/A LEU 36.A N LEU 33.A O no hydrogen 2.964 N/A GLY 37.A N LYS 34.A O no hydrogen 3.371 N/A PHE 38.A N LEU 33.A O no hydrogen 3.130 N/A GLU 39.A N ARG 54.A O no hydrogen 2.959 N/A GLU 41.A N.A TRP 52.A O no hydrogen 2.763 N/A GLU 41.A N.B TRP 52.A O no hydrogen 2.766 N/A SER 42.A OG ASN 50.A O no hydrogen 3.371 N/A MET 43.A N ASN 50.A O no hydrogen 2.923 N/A PHE 45.A N THR 48.A O no hydrogen 2.983 N/A THR 48.A N PHE 45.A O no hydrogen 3.002 N/A THR 48.A OG1 PHE 45.A O no hydrogen 3.035 N/A THR 49.A N SER 132.A OG no hydrogen 3.328 N/A ASN 50.A N MET 43.A O no hydrogen 2.946 N/A ASN 50.A ND2 MET 43.A O no hydrogen 2.735 N/A PHE 51.A N ILE 130.A O no hydrogen 2.755 N/A TRP 52.A N GLU 41.A O.A no hydrogen 3.003 N/A TRP 52.A N GLU 41.A O.B no hydrogen 2.981 N/A ALA 53.A N PHE 128.A O no hydrogen 2.930 N/A ARG 54.A N GLU 39.A O no hydrogen 2.976 N/A ARG 54.A NE GLY 56.A O no hydrogen 2.813 N/A ARG 54.A NH1 GLU 152.A OE2 no hydrogen 2.943 N/A ARG 54.A NH2 SER 125.A OG no hydrogen 2.666 N/A ARG 55.A N ILE 126.A O no hydrogen 2.826 N/A ARG 55.A NE HIS 122.A NE2 no hydrogen 2.940 N/A ARG 55.A NH2 PRO 120.A O no hydrogen 3.539 N/A GLN 58.A NE2 THR 57.A OG1 no hydrogen 3.178 N/A LEU 61.A N ASP 155.A OD2 no hydrogen 2.708 N/A PHE 62.A N SER 125.A O no hydrogen 2.953 N/A VAL 63.A N MET 156.A O no hydrogen 2.818 N/A PHE 64.A N GLY 127.A O no hydrogen 2.954 N/A ALA 65.A N ILE 158.A O no hydrogen 2.913 N/A GLY 66.A N LEU 129.A O no hydrogen 3.224 N/A HIS 67.A ND1 ASP 69.A O no hydrogen 2.815 N/A HIS 67.A NE2 ASP 100.A OD1 no hydrogen 3.028 N/A THR 68.A N THR 131.A O no hydrogen 2.827 N/A THR 68.A OG1 ASP 22.A OD1 no hydrogen 2.774 N/A THR 68.A OG1 THR 131.A O no hydrogen 3.067 N/A VAL 70.A N SER 17.A O no hydrogen 2.976 N/A GLN 78.A N PRO 75.A O no hydrogen 2.910 N/A TRP 79.A N LEU 76.A O no hydrogen 3.077 N/A TRP 79.A NE1 ALA 73.A O no hydrogen 2.755 N/A HIS 80.A N ASN 239.A OD1 no hydrogen 2.759 N/A GLU 85.A N PRO 82.A O no hydrogen 2.945 N/A THR 87.A N HIS 94.A O no hydrogen 3.144 N/A THR 87.A OG1 GLU 85.A O no hydrogen 2.537 N/A ILE 89.A N PHE 92.A O no hydrogen 3.000 N/A PHE 92.A N ILE 89.A O no hydrogen 2.957 N/A LEU 93.A N VAL 242.A O no hydrogen 2.918 N/A HIS 94.A N THR 87.A O no hydrogen 2.836 N/A GLY 95.A N GLU 240.A O no hydrogen 2.835 N/A ARG 96.A N PRO 83.A O no hydrogen 2.940 N/A ARG 96.A NE VAL 71.A O no hydrogen 3.026 N/A ARG 96.A NE PRO 72.A O no hydrogen 3.177 N/A ARG 96.A NH1 LYS 237.A O no hydrogen 2.721 N/A ARG 96.A NH1 GLU 240.A OE2 no hydrogen 2.898 N/A ARG 96.A NH2 PRO 72.A O no hydrogen 2.873 N/A ARG 96.A NH2 LYS 237.A O no hydrogen 3.307 N/A GLY 97.A N GLU 240.A OE2 no hydrogen 2.958 N/A ALA 98.A N GLY 95.A O no hydrogen 2.996 N/A ALA 99.A N GLU 240.A OE1 no hydrogen 2.780 N/A ASP 100.A N GLU 240.A OE1 no hydrogen 2.849 N/A LYS 102.A N GLY 97.A O no hydrogen 2.773 N/A LYS 102.A NZ LEU 12.A O no hydrogen 2.908 N/A LYS 102.A NZ SER 17.A OG no hydrogen 2.912 N/A SER 104.A OG GLY 160.A O no hydrogen 2.748 N/A LEU 105.A N MET 101.A O no hydrogen 3.192 N/A ALA 106.A N LYS 102.A O no hydrogen 3.053 N/A CYS 107.A N GLY 103.A O no hydrogen 3.011 N/A CYS 107.A SG GLY 103.A O no hydrogen 3.311 N/A CYS 107.A SG LEU 247.A O no hydrogen 3.205 N/A CYS 107.A SG THR 251.A OG1 no hydrogen 3.185 N/A MET 108.A N SER 104.A O no hydrogen 2.809 N/A ILE 109.A N LEU 105.A O no hydrogen 3.042 N/A VAL 110.A N ALA 106.A O no hydrogen 3.082 N/A ALA 111.A N CYS 107.A O no hydrogen 2.988 N/A VAL 112.A N MET 108.A O no hydrogen 3.042 N/A GLU 113.A N ILE 109.A O no hydrogen 2.955 N/A ARG 114.A N VAL 110.A O no hydrogen 2.747 N/A PHE 115.A N ALA 111.A O no hydrogen 2.838 N/A ILE 116.A N VAL 112.A O no hydrogen 2.731 N/A ALA 117.A N GLU 113.A O no hydrogen 3.094 N/A GLU 118.A N ARG 114.A O no hydrogen 3.102 N/A HIS 119.A N PHE 115.A O no hydrogen 2.665 N/A HIS 122.A N HIS 119.A O no hydrogen 3.186 N/A HIS 122.A ND1 GLN 123.A O no hydrogen 2.878 N/A GLN 123.A N LEU 262.A O no hydrogen 2.967 N/A SER 125.A N PRO 60.A O no hydrogen 2.836 N/A SER 125.A OG GLN 58.A O no hydrogen 2.778 N/A ILE 126.A N ARG 55.A O no hydrogen 2.832 N/A GLY 127.A N PHE 62.A O no hydrogen 2.756 N/A PHE 128.A N ALA 53.A O no hydrogen 2.891 N/A LEU 129.A N PHE 64.A O no hydrogen 2.936 N/A ILE 130.A N PHE 51.A O no hydrogen 2.867 N/A THR 131.A N GLY 66.A O no hydrogen 3.110 N/A SER 132.A OG PRO 20.A O no hydrogen 3.005 N/A SER 132.A OG THR 49.A O no hydrogen 3.269 N/A GLU 134.A N ASP 69.A OD1 no hydrogen 3.298 N/A GLU 135.A N ASP 69.A OD2 no hydrogen 3.081 N/A GLY 136.A N ASP 133.A O no hydrogen 3.138 N/A GLY 139.A N ASP 133.A OD2 no hydrogen 2.769 N/A THR 140.A OG1 ASP 214.A OD2 no hydrogen 3.185 N/A ARG 142.A N ASN 138.A O no hydrogen 3.065 N/A VAL 143.A N GLY 139.A O no hydrogen 3.071 N/A VAL 144.A N THR 140.A O no hydrogen 2.818 N/A GLU 145.A N VAL 141.A O no hydrogen 2.935 N/A THR 146.A N ARG 142.A O no hydrogen 3.233 N/A THR 146.A OG1 ARG 142.A O no hydrogen 2.808 N/A LEU 147.A N VAL 143.A O no hydrogen 3.053 N/A MET 148.A N VAL 144.A O no hydrogen 2.948 N/A ALA 149.A N GLU 145.A O no hydrogen 2.939 N/A ARG 150.A N LEU 147.A O no hydrogen 3.202 N/A ARG 150.A NE GLU 152.A OE1 no hydrogen 2.854 N/A ARG 150.A NH1 GLU 41.A OE1.B no hydrogen 3.065 N/A ARG 150.A NH1 GLU 41.A OE2.A no hydrogen 3.189 N/A ARG 150.A NH2 GLU 41.A OE2.A no hydrogen 3.482 N/A ARG 150.A NH2 GLU 41.A OE2.B no hydrogen 2.903 N/A ARG 150.A NH2 GLU 152.A OE1 no hydrogen 2.863 N/A ASN 151.A N MET 148.A O no hydrogen 2.818 N/A GLU 152.A N LEU 147.A O no hydrogen 2.748 N/A ASP 155.A N LEU 61.A O no hydrogen 2.880 N/A MET 156.A N LEU 61.A O no hydrogen 3.037 N/A CYS 157.A N GLN 224.A O no hydrogen 2.740 N/A CYS 157.A SG VAL 63.A O no hydrogen 3.826 N/A ILE 158.A N VAL 63.A O no hydrogen 2.863 N/A VAL 159.A N VAL 226.A O no hydrogen 2.992 N/A GLY 160.A N ALA 65.A O no hydrogen 3.285 N/A SER 163.A OG VAL 171.A O no hydrogen 2.872 N/A SER 164.A N PRO 230.A O no hydrogen 3.186 N/A SER 164.A OG GLY 229.A O no hydrogen 2.659 N/A THR 165.A N ASP 170.A OD1 no hydrogen 2.786 N/A LEU 166.A N ASP 170.A OD2 no hydrogen 2.804 N/A ALA 167.A N ASP 170.A OD2 no hydrogen 3.006 N/A VAL 168.A N ASP 246.A OD2 no hydrogen 3.082 N/A GLY 169.A N SER 164.A OG no hydrogen 2.809 N/A ASP 170.A N ALA 167.A O no hydrogen 3.087 N/A VAL 172.A N ALA 205.A O no hydrogen 3.008 N/A LYS 173.A N GLU 227.A O no hydrogen 3.132 N/A LYS 173.A NZ GLU 227.A OE2 no hydrogen 3.541 N/A ASN 174.A N LEU 207.A O no hydrogen 2.752 N/A GLY 175.A N VAL 225.A O no hydrogen 2.844 N/A ARG 176.A NE THR 208.A O no hydrogen 3.425 N/A ARG 176.A NH2 THR 208.A OG1 no hydrogen 3.408 N/A ARG 177.A NE GLY 222.A O no hydrogen 2.731 N/A ARG 177.A NH1 THR 183.A O no hydrogen 2.713 N/A GLY 178.A N ALA 219.A O no hydrogen 2.918 N/A GLY 179.A N ARG 176.A O no hydrogen 2.949 N/A GLY 180.A N ARG 177.A O no hydrogen 3.039 N/A PHE 181.A N GLY 178.A O no hydrogen 3.209 N/A LEU 182.A N ARG 177.A O no hydrogen 3.446 N/A GLY 186.A N ASP 184.A OD1 no hydrogen 3.036 N/A GLU 187.A N THR 185.A OG1 no hydrogen 3.400 N/A LEU 188.A N GLN 224.A OE1 no hydrogen 3.027 N/A ALA 190.A N GLY 186.A O no hydrogen 2.927 N/A ALA 191.A N GLU 187.A O no hydrogen 3.116 N/A VAL 192.A N LEU 188.A O no hydrogen 2.863 N/A VAL 193.A N LEU 189.A O no hydrogen 2.809 N/A ALA 194.A N ALA 190.A O no hydrogen 2.956 N/A ALA 195.A N ALA 191.A O no hydrogen 2.994 N/A VAL 196.A N VAL 192.A O no hydrogen 2.855 N/A GLU 197.A N VAL 193.A O no hydrogen 2.868 N/A GLU 198.A N ALA 194.A O no hydrogen 3.032 N/A VAL 199.A N ALA 195.A O no hydrogen 3.160 N/A ASN 200.A N VAL 196.A O no hydrogen 2.926 N/A ASN 200.A ND2 VAL 168.A O no hydrogen 2.906 N/A HIS 201.A N GLU 197.A O no hydrogen 2.714 N/A GLN 202.A NE2.B ALA 203.A O no hydrogen 2.802 N/A ALA 205.A N ASP 170.A O no hydrogen 2.737 N/A LEU 207.A N VAL 172.A O no hydrogen 3.001 N/A GLY 215.A N THR 212.A OG1 no hydrogen 3.053 N/A ARG 216.A N THR 212.A O no hydrogen 3.041 N/A ARG 216.A NH2 GLY 210.A O.B no hydrogen 3.008 N/A ARG 216.A NH2 GLY 211.A O.A no hydrogen 2.955 N/A ARG 216.A NH2 GLY 211.A O.B no hydrogen 2.874 N/A PHE 217.A N SER 213.A O no hydrogen 2.846 N/A ILE 218.A N ASP 214.A O no hydrogen 3.203 N/A ALA 219.A N GLY 215.A O no hydrogen 3.048 N/A GLN 220.A N ARG 216.A O no hydrogen 2.906 N/A MET 221.A N PHE 217.A O no hydrogen 3.082 N/A GLY 222.A N ALA 219.A O no hydrogen 2.803 N/A ALA 223.A N ILE 218.A O no hydrogen 3.328 N/A GLN 224.A N ASP 155.A O no hydrogen 3.048 N/A VAL 226.A N CYS 157.A O no hydrogen 3.062 N/A GLU 227.A N LYS 173.A O no hydrogen 2.732 N/A LEU 228.A N VAL 159.A O no hydrogen 3.185 N/A GLY 229.A N SER 163.A OG no hydrogen 3.168 N/A ASN 232.A N SER 164.A O no hydrogen 3.036 N/A ASN 232.A ND2 PRO 162.A O no hydrogen 2.907 N/A THR 234.A OG1 CYS 241.A O no hydrogen 3.440 N/A ILE 235.A N ASN 232.A O no hydrogen 3.375 N/A HIS 236.A NE2 GLU 135.A OE2 no hydrogen 3.066 N/A LYS 237.A N THR 234.A O no hydrogen 3.310 N/A LYS 237.A NZ ALA 233.A O no hydrogen 2.889 N/A LYS 237.A NZ ILE 235.A O no hydrogen 3.360 N/A ASN 239.A ND2 GLN 78.A O no hydrogen 3.135 N/A CYS 241.A N THR 234.A OG1 no hydrogen 3.011 N/A VAL 242.A N LEU 93.A O no hydrogen 2.980 N/A ILE 244.A N GLY 91.A O no hydrogen 2.982 N/A ASP 246.A N ARG 243.A O no hydrogen 2.895 N/A LEU 247.A N ARG 243.A O no hydrogen 3.275 N/A LEU 247.A N ILE 244.A O no hydrogen 2.784 N/A GLU 248.A N ILE 244.A O no hydrogen 3.136 N/A LYS 249.A N ALA 245.A O no hydrogen 3.093 N/A LYS 249.A NZ ASN 200.A OD1 no hydrogen 3.093 N/A LEU 250.A N ASP 246.A O no hydrogen 2.952 N/A THR 251.A N LEU 247.A O no hydrogen 3.080 N/A THR 251.A OG1 LEU 247.A O no hydrogen 2.959 N/A ASP 252.A N GLU 248.A O no hydrogen 3.144 N/A MET 253.A N LYS 249.A O no hydrogen 2.866 N/A TYR 254.A N LEU 250.A O no hydrogen 2.882 N/A TYR 254.A OH LEU 228.A O no hydrogen 2.880 N/A GLN 255.A N THR 251.A O no hydrogen 2.922 N/A LYS 256.A N ASP 252.A O no hydrogen 2.808 N/A LYS 256.A NZ GLU 198.A OE1.A no hydrogen 3.226 N/A LYS 256.A NZ GLU 198.A OE2.B no hydrogen 2.473 N/A THR 257.A N MET 253.A O no hydrogen 2.925 N/A THR 257.A OG1 MET 253.A O no hydrogen 2.786 N/A LEU 258.A N TYR 254.A O no hydrogen 3.060 N/A ASN 259.A N GLN 255.A O no hydrogen 2.910 N/A HIS 260.A N LYS 256.A O no hydrogen 3.060 N/A HIS 260.A NE2 GLU 198.A OE2.A no hydrogen 2.779 N/A LEU 261.A N THR 257.A O no hydrogen 3.088 N/A LEU 261.A N LEU 258.A O no hydrogen 3.126 N/A LEU 262.A N LEU 258.A O no hydrogen 2.759 N/A GLY 263.A N ASN 259.A O no hydrogen 2.906 N/A