Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4r8w_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 10.A N ASN 313.A OD1 no hydrogen 2.912 N/A GLY 13.A N GLU 25.A OE1 no hydrogen 2.968 N/A THR 14.A N VAL 26.A O no hydrogen 2.880 N/A LYS 15.A NZ GLY 23.A O no hydrogen 3.029 N/A VAL 16.A N VAL 24.A O no hydrogen 2.827 N/A THR 18.A N GLU 21.A O no hydrogen 3.034 N/A THR 18.A OG1 GLU 21.A O no hydrogen 3.278 N/A GLU 21.A N THR 18.A OG1 no hydrogen 2.948 N/A GLY 23.A N ASN 17.A OD1 no hydrogen 3.164 N/A VAL 24.A N VAL 16.A O no hydrogen 2.888 N/A VAL 26.A N THR 14.A O no hydrogen 2.718 N/A VAL 27.A N MET 311.A O no hydrogen 2.832 N/A THR 30.A N LEU 307.A O no hydrogen 2.875 N/A THR 32.A N GLU 31.A OE2 no hydrogen 2.530 N/A VAL 33.A N GLU 31.A OE2 no hydrogen 2.527 N/A GLU 34.A N PHE 285.A O no hydrogen 2.723 N/A ARG 35.A NH1 GLU 31.A OE1 no hydrogen 3.183 N/A ARG 35.A NH1 ARG 303.A O no hydrogen 2.931 N/A THR 36.A N GLU 34.A OE2 no hydrogen 2.914 N/A ASN 37.A ND2 GLY 276.A O no hydrogen 3.583 N/A ILE 38.A N THR 278.A O no hydrogen 3.021 N/A ARG 40.A N ILE 38.A O no hydrogen 2.573 N/A ARG 40.A NE ASP 265.A OD2 no hydrogen 2.879 N/A ILE 41.A N GLN 263.A O no hydrogen 2.927 N/A CYS 42.A N THR 278.A OG1 no hydrogen 3.002 N/A SER 43.A N ASP 265.A O no hydrogen 2.942 N/A LYS 44.A N CYS 268.A O no hydrogen 3.082 N/A LYS 44.A NZ ASN 267.A O no hydrogen 3.227 N/A LYS 46.A N SER 43.A O no hydrogen 3.300 N/A LYS 46.A NZ GLY 270.A O no hydrogen 3.026 N/A LYS 46.A NZ ASP 271.A OD1 no hydrogen 3.284 N/A LYS 46.A NZ TYR 273.A OH no hydrogen 3.214 N/A ARG 47.A N ASP 75.A OD2 no hydrogen 2.930 N/A THR 48.A OG1 LYS 46.A O no hydrogen 3.147 N/A VAL 49.A N LEU 76.A O no hydrogen 2.929 N/A LEU 51.A N ILE 78.A O no hydrogen 2.999 N/A GLY 52.A N ASP 50.A OD1 no hydrogen 3.113 N/A CYS 54.A N LEU 51.A O no hydrogen 2.753 N/A CYS 54.A SG GLY 55.A O no hydrogen 3.324 N/A GLY 55.A N SER 84.A O no hydrogen 3.098 N/A LEU 57.A N ASP 85.A OD1 no hydrogen 3.114 N/A GLY 58.A N GLY 55.A O no hydrogen 2.565 N/A THR 59.A N LEU 56.A O no hydrogen 3.399 N/A THR 59.A OG1 LEU 56.A O no hydrogen 2.946 N/A ILE 60.A N LEU 57.A O no hydrogen 2.978 N/A GLY 62.A N GLY 58.A O no hydrogen 2.509 N/A GLN 65.A N GLN 65.A OE1 no hydrogen 2.738 N/A CYS 66.A N PRO 63.A O no hydrogen 2.671 N/A CYS 66.A SG GLY 55.A O no hydrogen 3.672 N/A ASP 67.A N PRO 64.A O no hydrogen 3.369 N/A PHE 69.A N CYS 66.A O no hydrogen 3.043 N/A PHE 72.A N PHE 69.A O no hydrogen 3.092 N/A ALA 74.A N GLY 106.A O no hydrogen 2.790 N/A ASP 75.A N ARG 47.A O no hydrogen 2.847 N/A LEU 76.A N ARG 47.A O no hydrogen 3.197 N/A ILE 77.A N MET 256.A O no hydrogen 2.834 N/A ILE 78.A N VAL 49.A O no hydrogen 2.894 N/A GLU 79.A N ILE 258.A O no hydrogen 2.874 N/A ARG 80.A NE ASP 50.A OD1 no hydrogen 2.998 N/A ARG 80.A NE ASP 50.A OD2 no hydrogen 3.082 N/A ARG 80.A NH1 SER 260.A O no hydrogen 2.918 N/A ARG 80.A NH1 VAL 262.A O no hydrogen 2.811 N/A ARG 80.A NH2 ASP 50.A OD2 no hydrogen 2.719 N/A ARG 80.A NH2 VAL 262.A O no hydrogen 2.865 N/A GLU 82.A N GLU 82.A OE1 no hydrogen 2.772 N/A GLY 83.A N ARG 80.A O no hydrogen 2.896 N/A SER 84.A OG VAL 86.A O no hydrogen 2.965 N/A VAL 86.A N SER 84.A OG no hydrogen 3.412 N/A CYS 87.A N TYR 137.A OH no hydrogen 3.152 N/A LYS 91.A N ILE 221.A O no hydrogen 3.151 N/A VAL 93.A N PHE 223.A O no hydrogen 2.965 N/A LEU 98.A N ASN 94.A O no hydrogen 3.408 N/A ARG 99.A N GLU 95.A O no hydrogen 3.055 N/A ARG 99.A NH1 GLU 95.A OE1 no hydrogen 2.637 N/A ARG 99.A NH1 GLU 96.A OE1 no hydrogen 3.465 N/A ARG 99.A NH2 ASP 85.A OD2 no hydrogen 2.965 N/A ARG 99.A NH2 GLU 95.A OE1 no hydrogen 3.134 N/A GLN 100.A N GLU 96.A O no hydrogen 3.267 N/A ILE 101.A N ALA 97.A O no hydrogen 3.196 N/A LEU 102.A N LEU 98.A O no hydrogen 2.974 N/A ARG 103.A N ARG 99.A O no hydrogen 2.819 N/A ARG 103.A NH1 GLU 96.A OE2 no hydrogen 3.447 N/A GLU 104.A N GLN 100.A O no hydrogen 3.385 N/A GLU 104.A N ILE 101.A O no hydrogen 3.218 N/A SER 105.A N LEU 102.A O no hydrogen 3.320 N/A SER 105.A OG LEU 102.A O no hydrogen 2.495 N/A GLY 106.A N SER 255.A OG no hydrogen 2.814 N/A GLY 107.A N SER 105.A OG no hydrogen 3.227 N/A ILE 108.A N PHE 72.A O no hydrogen 3.044 N/A ASP 109.A N PHE 250.A O no hydrogen 2.906 N/A LYS 110.A N GLU 71.A OE1 no hydrogen 3.163 N/A LYS 110.A NZ THR 59.A O no hydrogen 2.856 N/A LYS 110.A NZ LEU 70.A O no hydrogen 2.748 N/A LYS 110.A NZ GLU 139.A OE2 no hydrogen 2.385 N/A GLU 111.A N ALA 248.A O no hydrogen 2.881 N/A MET 113.A N ASP 246.A O no hydrogen 3.097 N/A SER 118.A OG TYR 117.A O no hydrogen 2.720 N/A THR 122.A OG1 THR 122.A O no hydrogen 2.516 N/A GLY 124.A N TRP 142.A O no hydrogen 3.366 N/A THR 126.A N SER 135.A O no hydrogen 2.924 N/A ALA 128.A N THR 126.A OG1 no hydrogen 2.969 N/A CYS 129.A N THR 126.A O no hydrogen 3.263 N/A ARG 131.A N GLY 133.A O no hydrogen 3.179 N/A ARG 131.A NE ASP 67.A OD2 no hydrogen 2.745 N/A ARG 131.A NH1 SER 135.A OG no hydrogen 3.011 N/A ARG 131.A NH1 PHE 136.A O no hydrogen 2.715 N/A ARG 131.A NH2 GLY 62.A O no hydrogen 3.211 N/A ARG 131.A NH2 ASP 67.A OD1 no hydrogen 2.440 N/A ARG 131.A NH2 ASP 67.A OD2 no hydrogen 3.199 N/A SER 135.A N THR 126.A O no hydrogen 3.230 N/A SER 135.A N CYS 129.A O no hydrogen 2.602 N/A PHE 136.A N SER 135.A OG no hydrogen 2.541 N/A TYR 137.A OH TYR 88.A O no hydrogen 2.945 N/A ALA 138.A N GLY 62.A O no hydrogen 2.704 N/A GLU 139.A N THR 61.A O no hydrogen 3.140 N/A MET 140.A N TYR 137.A O no hydrogen 3.080 N/A LYS 141.A N ALA 244.A O no hydrogen 2.846 N/A TRP 142.A NE1 TYR 186.A OH no hydrogen 3.171 N/A SER 145.A N LEU 185.A O no hydrogen 3.129 N/A SER 145.A OG ALA 151.A O no hydrogen 3.354 N/A SER 145.A OG LEU 185.A O no hydrogen 3.178 N/A SER 145.A OG TYR 186.A O no hydrogen 3.337 N/A ASN 149.A ND2 ASP 148.A O no hydrogen 3.317 N/A MET 155.A N PHE 238.A O no hydrogen 2.782 N/A LYS 157.A N PHE 236.A O no hydrogen 2.851 N/A LYS 157.A NZ THR 116.A O no hydrogen 3.005 N/A SER 158.A OG VAL 234.A O no hydrogen 3.363 N/A TYR 159.A N VAL 234.A O no hydrogen 2.943 N/A TYR 159.A OH GLU 111.A OE1 no hydrogen 2.607 N/A ASN 161.A N ASP 232.A O no hydrogen 3.034 N/A ASN 161.A ND2 SER 165.A O no hydrogen 2.915 N/A ASN 161.A ND2 LEU 228.A O no hydrogen 3.224 N/A ARG 163.A N ASN 161.A OD1 no hydrogen 3.344 N/A ARG 163.A NH1 ASP 109.A OD2 no hydrogen 3.541 N/A ARG 163.A NH1 GLU 111.A OE2 no hydrogen 3.301 N/A ARG 163.A NH2 ASP 109.A OD2 no hydrogen 3.564 N/A SER 165.A OG PRO 166.A O no hydrogen 3.514 N/A ALA 167.A N LEU 228.A O no hydrogen 2.729 N/A LEU 168.A N SER 249.A O no hydrogen 2.817 N/A ILE 169.A N LEU 226.A O no hydrogen 2.875 N/A TRP 171.A N HIS 224.A O no hydrogen 3.043 N/A GLY 172.A N ILE 243.A O no hydrogen 2.844 N/A ILE 173.A N ASP 222.A O no hydrogen 2.897 N/A HIS 174.A N ALA 241.A O no hydrogen 3.167 N/A HIS 174.A NE2 TYR 88.A OH no hydrogen 3.196 N/A HIS 175.A N ARG 220.A O no hydrogen 2.729 N/A HIS 175.A NE2 ASP 222.A OD2 no hydrogen 2.568 N/A VAL 177.A N GLU 181.A OE1 no hydrogen 2.689 N/A GLU 181.A N SER 178.A OG no hydrogen 3.393 N/A GLN 182.A N SER 178.A O no hydrogen 3.439 N/A THR 183.A N THR 179.A O no hydrogen 3.229 N/A THR 183.A OG1 THR 179.A O no hydrogen 3.330 N/A THR 183.A OG1 ALA 180.A O no hydrogen 2.662 N/A LYS 184.A N ALA 180.A O no hydrogen 3.132 N/A LEU 185.A N GLU 181.A O no hydrogen 2.992 N/A TYR 186.A N GLN 182.A O no hydrogen 2.802 N/A TYR 186.A OH HIS 174.A ND1 no hydrogen 2.893 N/A GLY 187.A N GLN 182.A O no hydrogen 3.322 N/A LYS 191.A NZ ASN 239.A O no hydrogen 2.850 N/A LEU 192.A N ASN 239.A OD1 no hydrogen 2.630 N/A VAL 193.A N PHE 204.A O no hydrogen 3.139 N/A THR 194.A N SER 237.A O no hydrogen 2.863 N/A VAL 195.A N GLN 202.A O no hydrogen 2.973 N/A GLY 196.A N THR 235.A O no hydrogen 3.178 N/A SER 197.A N TYR 200.A O no hydrogen 3.059 N/A SER 197.A OG ASP 232.A OD2 no hydrogen 3.107 N/A SER 198.A N ASP 232.A OD2 no hydrogen 3.250 N/A SER 198.A OG ASP 232.A OD1 no hydrogen 2.717 N/A TYR 200.A N SER 197.A OG no hydrogen 3.156 N/A GLN 202.A N VAL 195.A O no hydrogen 3.136 N/A PHE 204.A N VAL 193.A O no hydrogen 2.720 N/A GLY 209.A N SER 176.A O no hydrogen 3.158 N/A ARG 211.A NH2 SER 207.A O no hydrogen 2.355 N/A VAL 214.A N LEU 217.A O no hydrogen 2.900 N/A ASN 215.A ND2 CYS 87.A O no hydrogen 2.893 N/A LEU 217.A N VAL 214.A O no hydrogen 3.215 N/A SER 218.A OG ARG 211.A O no hydrogen 2.905 N/A ARG 220.A N HIS 175.A O no hydrogen 2.945 N/A ARG 220.A NH1 LEU 217.A O no hydrogen 3.276 N/A ARG 220.A NH1 GLY 219.A O no hydrogen 2.791 N/A ARG 220.A NH2 PRO 212.A O no hydrogen 2.559 N/A ILE 221.A N PRO 89.A O no hydrogen 3.230 N/A ASP 222.A N ILE 173.A O no hydrogen 2.947 N/A PHE 223.A N LYS 91.A O no hydrogen 2.918 N/A HIS 224.A N TRP 171.A O no hydrogen 3.008 N/A TRP 225.A NE1 VAL 93.A O no hydrogen 3.011 N/A LEU 226.A N ILE 169.A O no hydrogen 2.978 N/A LEU 228.A N ALA 167.A O no hydrogen 2.870 N/A ASN 231.A N ASN 161.A O no hydrogen 2.744 N/A ASP 232.A N ASN 229.A O no hydrogen 2.991 N/A THR 233.A N ASP 232.A OD1 no hydrogen 2.633 N/A VAL 234.A N TYR 159.A O no hydrogen 2.956 N/A THR 235.A N GLY 196.A O no hydrogen 3.081 N/A PHE 236.A N LYS 157.A O no hydrogen 2.658 N/A SER 237.A N THR 194.A O no hydrogen 2.965 N/A SER 237.A OG THR 194.A OG1 no hydrogen 3.192 N/A PHE 238.A N MET 155.A O no hydrogen 2.976 N/A ASN 239.A ND2 ASN 190.A O no hydrogen 3.062 N/A ILE 243.A N GLY 172.A O no hydrogen 2.675 N/A ALA 244.A N LYS 141.A O no hydrogen 3.077 N/A ASP 246.A N GLU 139.A O no hydrogen 2.667 N/A ALA 248.A N GLU 111.A O no hydrogen 2.785 N/A SER 249.A N LEU 168.A O no hydrogen 3.121 N/A PHE 250.A N ASP 109.A O no hydrogen 3.118 N/A ARG 252.A N GLY 107.A O no hydrogen 3.111 N/A ARG 252.A NE PHE 72.A O no hydrogen 3.035 N/A ARG 252.A NE ILE 108.A O no hydrogen 2.710 N/A ARG 252.A NH2 GLU 71.A O no hydrogen 3.242 N/A ARG 252.A NH2 ILE 108.A O no hydrogen 3.057 N/A GLY 253.A N SER 105.A O no hydrogen 2.840 N/A SER 255.A OG ARG 103.A O no hydrogen 2.779 N/A MET 256.A N ASP 75.A O no hydrogen 2.950 N/A ILE 258.A N ILE 77.A O no hydrogen 2.856 N/A GLN 259.A NE2 GLU 79.A OE2 no hydrogen 3.547 N/A SER 260.A N GLU 79.A O no hydrogen 3.322 N/A SER 260.A OG SER 275.A O no hydrogen 3.039 N/A GLY 261.A N SER 275.A O no hydrogen 3.202 N/A VAL 262.A N SER 260.A OG no hydrogen 3.294 N/A ASP 265.A N ILE 41.A O no hydrogen 2.892 N/A ASN 267.A N ASP 265.A OD1 no hydrogen 2.942 N/A CYS 268.A SG ASP 265.A O no hydrogen 3.734 N/A CYS 272.A SG VAL 293.A O no hydrogen 3.972 N/A TYR 273.A N VAL 293.A O no hydrogen 3.068 N/A TYR 273.A OH CYS 42.A O no hydrogen 2.471 N/A HIS 274.A N GLY 277.A O no hydrogen 2.960 N/A HIS 274.A NE2 ASN 37.A OD1 no hydrogen 2.701 N/A GLY 276.A N HIS 274.A ND1 no hydrogen 3.365 N/A GLY 277.A N HIS 274.A O no hydrogen 3.223 N/A THR 278.A N ILE 38.A O no hydrogen 2.758 N/A THR 278.A OG1 ARG 40.A O no hydrogen 2.553 N/A ILE 279.A N CYS 272.A O no hydrogen 2.898 N/A SER 281.A OG GLU 34.A OE1 no hydrogen 2.811 N/A LEU 283.A N SER 281.A OG no hydrogen 3.027 N/A PHE 285.A N THR 32.A O no hydrogen 3.395 N/A GLN 286.A N ARG 298.A O no hydrogen 2.935 N/A GLN 286.A NE2 ASP 289.A O no hydrogen 2.640 N/A ASN 287.A N GLU 34.A O no hydrogen 3.213 N/A ASN 287.A ND2 VAL 300.A O no hydrogen 2.549 N/A ASN 287.A ND2 LYS 301.A O no hydrogen 3.167 N/A ILE 288.A N GLN 286.A OE1 no hydrogen 2.885 N/A ASP 289.A N GLN 286.A OE1 no hydrogen 2.963 N/A ARG 291.A N ASP 289.A OD2 no hydrogen 2.781 N/A ALA 292.A N ASP 289.A O no hydrogen 3.235 N/A VAL 293.A N TYR 273.A O no hydrogen 3.043 N/A LYS 295.A N ASP 271.A O no hydrogen 2.824 N/A CYS 296.A SG VAL 293.A O no hydrogen 3.216 N/A ARG 298.A N PRO 284.A O no hydrogen 2.914 N/A VAL 300.A N GLN 286.A O no hydrogen 2.949 N/A GLN 302.A N GLN 302.A OE1 no hydrogen 2.527 N/A SER 304.A OG GLU 31.A OE1 no hydrogen 2.810 N/A LEU 305.A N GLU 31.A OE2 no hydrogen 3.269 N/A LEU 307.A N THR 30.A O no hydrogen 2.923 N/A THR 309.A N ASN 28.A O no hydrogen 2.820 N/A THR 309.A OG1 ASN 28.A O no hydrogen 2.904 N/A LYS 312.A NZ ASN 313.A O no hydrogen 3.559 N/A ASN 313.A N GLU 25.A O no hydrogen 2.894 N/A ASN 313.A ND2 VAL 10.A O no hydrogen 2.704 N/A ASN 313.A ND2 GLU 25.A OE1 no hydrogen 2.920 N/A