Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4tvi_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): TRP 4.A N LEU 117.A O no hydrogen 2.865 N/A THR 5.A N ARG 12.A O no hydrogen 2.684 N/A TYR 6.A N LEU 115.A O no hydrogen 2.828 N/A TYR 7.A N GLU 10.A O no hydrogen 2.979 N/A LYS 8.A NZ ASP 112.A OD2 no hydrogen 2.815 N/A GLU 10.A N TYR 7.A O no hydrogen 3.264 N/A ARG 12.A N THR 5.A O no hydrogen 2.639 N/A ARG 12.A NE TYR 7.A O no hydrogen 2.991 N/A ARG 12.A NH2 TYR 7.A O no hydrogen 2.971 N/A GLY 14.A N MET 3.A O no hydrogen 3.131 N/A ARG 17.A NE ASP 15.A OD2 no hydrogen 2.818 N/A ARG 17.A NH2 ASP 15.A OD1 no hydrogen 2.630 N/A ARG 17.A NH2 ASP 15.A OD2 no hydrogen 3.345 N/A GLY 20.A N SER 23.A OG no hydrogen 2.798 N/A SER 23.A N GLY 20.A O no hydrogen 3.131 N/A SER 23.A OG GLU 97.A OE1 no hydrogen 2.725 N/A SER 23.A OG GLU 97.A OE2 no hydrogen 3.518 N/A GLN 24.A N GLU 97.A O no hydrogen 2.974 N/A GLN 24.A NE2 VAL 104.A O no hydrogen 2.788 N/A ALA 25.A N ALA 96.A O no hydrogen 3.001 N/A THR 26.A N SER 23.A O no hydrogen 3.059 N/A THR 26.A OG1 GLY 20.A O no hydrogen 2.572 N/A LEU 28.A N GLN 24.A O no hydrogen 2.946 N/A GLY 29.A N ALA 25.A O no hydrogen 3.107 N/A SER 30.A OG GLN 24.A OE1 no hydrogen 2.767 N/A VAL 32.A N TYR 94.A O no hydrogen 2.801 N/A ASP 34.A N PRO 92.A O no hydrogen 3.120 N/A GLY 35.A N ASP 34.A OD1 no hydrogen 2.788 N/A ALA 36.A N ILE 90.A O no hydrogen 2.788 N/A ARG 37.A NE MET 246.A O no hydrogen 2.837 N/A ARG 37.A NH1 ILE 120.A O no hydrogen 2.931 N/A ARG 37.A NH2 ILE 120.A O no hydrogen 3.039 N/A ARG 37.A NH2 PRO 121.A O no hydrogen 3.525 N/A LEU 38.A N VAL 88.A O no hydrogen 2.709 N/A PHE 39.A N VAL 42.A O no hydrogen 3.036 N/A GLU 40.A N ASP 87.A OD1 no hydrogen 3.335 N/A VAL 42.A N PHE 39.A O no hydrogen 2.969 N/A LEU 46.A N THR 43.A O no hydrogen 3.232 N/A ARG 48.A N ASP 47.A OD1 no hydrogen 2.870 N/A ARG 48.A NH1 GLN 211.A OE1 no hydrogen 2.903 N/A ARG 48.A NH2 GLN 211.A OE1 no hydrogen 2.830 N/A HIS 49.A N ASP 45.A O no hydrogen 3.023 N/A HIS 49.A ND1 ASP 34.A OD1 no hydrogen 2.846 N/A SER 50.A N LEU 46.A O no hydrogen 2.942 N/A SER 50.A OG LEU 46.A O no hydrogen 2.704 N/A ALA 51.A N ASP 47.A O no hydrogen 3.046 N/A ARG 52.A N ARG 48.A O no hydrogen 3.023 N/A ARG 52.A NE ASP 34.A OD2 no hydrogen 2.699 N/A ARG 52.A NH2 ASP 34.A OD1 no hydrogen 2.973 N/A ARG 52.A NH2 ASP 34.A OD2 no hydrogen 3.465 N/A ALA 53.A N HIS 49.A O no hydrogen 3.392 N/A ASN 54.A ND2 LEU 66.A O no hydrogen 2.845 N/A ASP 55.A N ALA 51.A O no hydrogen 3.249 N/A SER 56.A N ARG 52.A O no hydrogen 2.771 N/A SER 56.A OG ARG 52.A O no hydrogen 3.269 N/A ALA 57.A N ALA 53.A O no hydrogen 2.993 N/A ARG 58.A N ASN 54.A O no hydrogen 3.089 N/A ARG 58.A NH2 ASP 55.A OD1 no hydrogen 3.419 N/A ALA 59.A N ASP 55.A O no hydrogen 2.923 N/A LEU 60.A N ALA 57.A O no hydrogen 2.991 N/A GLY 61.A N ARG 58.A O no hydrogen 3.015 N/A LEU 62.A N ALA 57.A O no hydrogen 2.894 N/A GLU 63.A N THR 111.A OG1 no hydrogen 2.974 N/A LEU 66.A N TYR 94.A OH no hydrogen 3.158 N/A SER 67.A N ASP 70.A OD2 no hydrogen 3.064 N/A ASP 70.A N SER 67.A OG no hydrogen 2.998 N/A ILE 71.A N SER 67.A O no hydrogen 3.119 N/A GLU 72.A N ALA 68.A O no hydrogen 3.050 N/A ALA 73.A N ASN 69.A O no hydrogen 2.858 N/A LEU 74.A N ASP 70.A O no hydrogen 2.843 N/A ALA 75.A N ILE 71.A O no hydrogen 2.865 N/A ARG 76.A N GLU 72.A O no hydrogen 3.009 N/A ARG 76.A NE GLU 72.A OE2 no hydrogen 3.449 N/A ARG 76.A NH1 THR 43.A OG1 no hydrogen 2.990 N/A ARG 76.A NH2 GLU 72.A OE2 no hydrogen 2.916 N/A GLU 77.A N ALA 73.A O no hydrogen 3.108 N/A GLY 78.A N LEU 74.A O no hydrogen 2.934 N/A LEU 79.A N ALA 75.A O no hydrogen 2.955 N/A LYS 80.A N GLU 77.A O no hydrogen 3.144 N/A LYS 81.A N GLY 78.A O no hydrogen 2.931 N/A PHE 82.A N LEU 79.A O no hydrogen 3.094 N/A THR 86.A OG1 ALA 83.A O no hydrogen 2.837 N/A VAL 88.A N LEU 38.A O no hydrogen 2.849 N/A TYR 89.A N GLU 118.A O no hydrogen 2.777 N/A ILE 90.A N ALA 36.A O no hydrogen 2.909 N/A ARG 91.A N CYS 116.A O no hydrogen 2.910 N/A ARG 91.A NH1 TYR 89.A OH no hydrogen 3.505 N/A MET 93.A N ALA 114.A O no hydrogen 2.796 N/A TYR 94.A N VAL 32.A O no hydrogen 3.064 N/A TYR 94.A OH ASN 54.A OD1 no hydrogen 2.793 N/A TRP 95.A N ASP 112.A O no hydrogen 3.250 N/A TRP 95.A NE1 GLU 97.A OE2 no hydrogen 2.904 N/A ALA 96.A N SER 30.A OG no hydrogen 3.163 N/A GLU 97.A N SER 110.A O no hydrogen 3.097 N/A GLU 98.A N SER 110.A OG no hydrogen 2.949 N/A ASP 100.A N ALA 105.A O no hydrogen 2.843 N/A SER 102.A N ASP 100.A OD1 no hydrogen 2.793 N/A SER 102.A OG ASP 100.A OD1 no hydrogen 2.480 N/A THR 103.A N ASP 100.A O no hydrogen 2.887 N/A VAL 104.A N SER 102.A O no hydrogen 2.623 N/A ALA 105.A N SER 102.A OG no hydrogen 3.111 N/A LEU 107.A N GLU 98.A O no hydrogen 2.848 N/A SER 110.A N LEU 107.A O no hydrogen 2.822 N/A SER 110.A OG GLU 98.A O no hydrogen 3.258 N/A SER 110.A OG LEU 107.A O no hydrogen 2.548 N/A THR 111.A N ALA 108.A O no hydrogen 3.012 N/A THR 111.A OG1 ALA 108.A O no hydrogen 2.592 N/A ASP 112.A N TRP 95.A O no hydrogen 2.874 N/A PHE 113.A N ASP 112.A OD1 no hydrogen 2.704 N/A ALA 114.A N MET 93.A O no hydrogen 3.002 N/A LEU 115.A N TYR 6.A O no hydrogen 3.001 N/A CYS 116.A N ARG 91.A O no hydrogen 2.957 N/A CYS 116.A SG THR 5.A OG1 no hydrogen 3.540 N/A LEU 117.A N TRP 4.A O no hydrogen 2.747 N/A GLU 118.A N TYR 89.A O no hydrogen 2.951 N/A ALA 119.A N ALA 2.A O no hydrogen 2.810 N/A ILE 120.A N ASP 87.A O no hydrogen 2.896 N/A MET 122.A N ASP 87.A OD2 no hydrogen 2.765 N/A PHE 128.A N PRO 251.A O no hydrogen 3.176 N/A THR 129.A N HIS 168.A ND1 no hydrogen 2.976 N/A THR 129.A OG1 HIS 168.A ND1 no hydrogen 3.134 N/A ILE 130.A N GLY 254.A O no hydrogen 2.709 N/A THR 131.A N ASN 169.A O no hydrogen 3.153 N/A THR 131.A OG1 ASP 256.A OD1 no hydrogen 2.732 N/A THR 133.A OG1 GLU 161.A OE1 no hydrogen 2.707 N/A SER 134.A N GLU 161.A OE1 no hydrogen 2.870 N/A SER 134.A OG GLU 161.A OE1 no hydrogen 3.450 N/A SER 134.A OG GLU 161.A OE2 no hydrogen 2.722 N/A PHE 135.A N THR 133.A OG1 no hydrogen 3.206 N/A ARG 137.A N THR 173.A O no hydrogen 2.905 N/A ARG 137.A NE THR 203.A O no hydrogen 2.906 N/A ARG 137.A NH2 THR 203.A O no hydrogen 3.134 N/A VAL 142.A N TYR 139.A O no hydrogen 2.945 N/A MET 143.A N TYR 139.A O no hydrogen 3.069 N/A VAL 145.A N MET 143.A O no hydrogen 2.766 N/A ALA 149.A N LEU 31.A O no hydrogen 2.968 N/A LEU 151.A N ALA 148.A O no hydrogen 3.176 N/A TYR 152.A N ALA 149.A O no hydrogen 3.227 N/A ASN 154.A ND2 ARG 136.A O no hydrogen 3.138 N/A ASN 155.A ND2 ALA 183.A O no hydrogen 2.666 N/A ALA 156.A N TYR 152.A O no hydrogen 2.848 N/A ARG 157.A N PRO 153.A O no hydrogen 3.191 N/A ARG 157.A NE ASN 154.A OD1 no hydrogen 2.968 N/A ARG 157.A NH2 ASN 154.A OD1 no hydrogen 3.071 N/A MET 158.A N ASN 154.A O no hydrogen 3.288 N/A LEU 159.A N ASN 155.A O no hydrogen 3.041 N/A ARG 160.A N ALA 156.A O no hydrogen 2.818 N/A GLU 161.A N ARG 157.A O no hydrogen 2.873 N/A ALA 162.A N MET 158.A O no hydrogen 2.876 N/A LYS 163.A N LEU 159.A O no hydrogen 2.832 N/A ALA 164.A N ARG 160.A O no hydrogen 2.926 N/A LYS 165.A N GLU 161.A O no hydrogen 3.060 N/A LYS 165.A N ALA 162.A O no hydrogen 2.972 N/A LYS 165.A NZ THR 132.A O no hydrogen 2.990 N/A GLY 166.A N LYS 163.A O no hydrogen 3.064 N/A PHE 167.A N ALA 162.A O no hydrogen 2.870 N/A HIS 168.A N THR 129.A OG1 no hydrogen 3.236 N/A ASN 169.A N THR 129.A O no hydrogen 3.088 N/A ASN 169.A ND2 THR 184.A OG1 no hydrogen 2.935 N/A ALA 170.A N ASN 169.A OD1 no hydrogen 2.572 N/A LEU 171.A N THR 131.A O no hydrogen 2.776 N/A VAL 172.A N GLU 181.A O no hydrogen 2.773 N/A THR 173.A OG1 ASP 174.A O no hydrogen 3.291 N/A ASP 174.A N ASN 178.A O no hydrogen 2.835 N/A GLY 177.A N ASP 174.A O no hydrogen 2.911 N/A ASN 178.A N ASP 174.A OD1 no hydrogen 3.002 N/A VAL 179.A N LEU 229.A O no hydrogen 2.731 N/A ALA 180.A N VAL 172.A O no hydrogen 2.781 N/A GLU 181.A N VAL 172.A O no hydrogen 3.460 N/A THR 182.A N SER 185.A O no hydrogen 2.787 N/A THR 182.A OG1 SER 185.A O no hydrogen 3.184 N/A THR 182.A OG1 SER 185.A OG no hydrogen 2.962 N/A ALA 183.A N ASN 169.A OD1 no hydrogen 3.025 N/A THR 184.A N THR 182.A OG1 no hydrogen 3.055 N/A SER 185.A OG THR 182.A OG1 no hydrogen 2.962 N/A ASN 186.A ND2 LEU 205.A O no hydrogen 2.886 N/A PHE 188.A N PHE 241.A O no hydrogen 2.733 N/A MET 189.A N PHE 196.A O no hydrogen 2.752 N/A VAL 190.A N GLU 239.A O no hydrogen 2.771 N/A ARG 191.A N GLU 194.A O no hydrogen 2.813 N/A ARG 191.A NH1 ASP 233.A OD1 no hydrogen 3.077 N/A ARG 191.A NH1 GLU 236.A OE1 no hydrogen 2.946 N/A GLY 192.A N ASP 238.A OD2 no hydrogen 2.966 N/A GLU 194.A N ARG 191.A O no hydrogen 3.036 N/A VAL 195.A N SER 223.A O no hydrogen 2.896 N/A PHE 196.A N MET 189.A O no hydrogen 2.731 N/A THR 197.A N HIS 225.A O no hydrogen 3.047 N/A THR 197.A OG1 VAL 187.A O no hydrogen 2.678 N/A VAL 199.A N THR 227.A O no hydrogen 2.888 N/A ASN 201.A ND2 ASP 174.A OD2 no hydrogen 3.031 N/A THR 203.A N ASN 201.A OD1 no hydrogen 3.136 N/A THR 203.A OG1 ASN 201.A OD1 no hydrogen 2.711 N/A GLY 207.A N ASN 186.A OD1 no hydrogen 3.044 N/A ARG 210.A NH1 GLU 226.A OE1 no hydrogen 3.173 N/A ARG 210.A NH2 PRO 198.A O no hydrogen 3.264 N/A ARG 210.A NH2 GLU 226.A OE1 no hydrogen 2.496 N/A GLN 211.A N GLY 207.A O no hydrogen 3.100 N/A GLN 211.A NE2 ASN 206.A O no hydrogen 2.863 N/A GLN 211.A NE2 GLY 207.A O no hydrogen 3.305 N/A ARG 212.A N ILE 208.A O no hydrogen 3.118 N/A ARG 212.A NE ASP 45.A OD2 no hydrogen 3.130 N/A ARG 212.A NH2 ASP 45.A OD1 no hydrogen 2.757 N/A VAL 213.A N THR 209.A O no hydrogen 2.926 N/A ILE 214.A N ARG 210.A O no hydrogen 2.980 N/A LYS 215.A N GLN 211.A O no hydrogen 2.985 N/A LYS 215.A NZ GLU 219.A OE2 no hydrogen 2.967 N/A LEU 216.A N ARG 212.A O no hydrogen 2.925 N/A LEU 217.A N VAL 213.A O no hydrogen 2.842 N/A ARG 218.A N ILE 214.A O no hydrogen 2.999 N/A ARG 218.A NE VAL 224.A O no hydrogen 3.324 N/A ARG 218.A NH2 VAL 224.A O no hydrogen 2.793 N/A ARG 218.A NH2 GLU 226.A OE2 no hydrogen 3.423 N/A GLU 219.A N LYS 215.A O no hydrogen 3.064 N/A ALA 220.A N LEU 216.A O no hydrogen 3.023 N/A ALA 220.A N LEU 217.A O no hydrogen 3.068 N/A GLY 221.A N ARG 218.A O no hydrogen 3.034 N/A VAL 222.A N LEU 217.A O no hydrogen 2.923 N/A HIS 225.A N VAL 195.A O no hydrogen 2.754 N/A HIS 225.A NE2 GLU 194.A OE2 no hydrogen 2.873 N/A THR 227.A N THR 197.A O no hydrogen 3.209 N/A LYS 230.A N ASP 233.A OD2 no hydrogen 2.730 N/A LYS 230.A NZ GLY 177.A O no hydrogen 3.434 N/A GLU 232.A N GLU 232.A OE1 no hydrogen 2.523 N/A ASP 233.A N LYS 230.A O no hydrogen 2.984 N/A ARG 235.A N ILE 231.A O no hydrogen 3.009 N/A ARG 235.A NH1 ASP 256.A OD2 no hydrogen 2.844 N/A ARG 235.A NH2 ASP 256.A OD2 no hydrogen 3.241 N/A GLU 236.A N GLU 232.A O no hydrogen 3.290 N/A GLU 236.A N ASP 233.A O no hydrogen 3.226 N/A ALA 237.A N PHE 234.A O no hydrogen 3.315 N/A ASP 238.A N VAL 190.A O no hydrogen 2.788 N/A GLU 239.A N VAL 190.A O no hydrogen 3.269 N/A PHE 241.A N PHE 188.A O no hydrogen 3.012 N/A SER 242.A N VAL 250.A O no hydrogen 2.657 N/A SER 242.A OG VAL 250.A O no hydrogen 3.461 N/A THR 243.A N ASN 186.A O no hydrogen 3.140 N/A GLY 244.A N LYS 248.A O no hydrogen 3.285 N/A ASN 245.A ND2 ALA 36.A O no hydrogen 3.139 N/A LYS 248.A N GLY 244.A O no hydrogen 2.867 N/A LYS 248.A NZ ASN 245.A O no hydrogen 3.103 N/A LYS 248.A NZ ASN 245.A OD1 no hydrogen 3.117 N/A VAL 249.A N SER 247.A O no hydrogen 2.659 N/A VAL 250.A N SER 242.A O no hydrogen 2.872 N/A ILE 252.A N ILE 240.A O no hydrogen 2.754 N/A ILE 253.A N PHE 128.A O no hydrogen 2.848 N/A PHE 255.A N ARG 258.A O no hydrogen 2.890 N/A ASP 256.A N ILE 130.A O no hydrogen 2.949 N/A ARG 258.A N PHE 255.A O no hydrogen 3.037 N/A ARG 258.A NH1 ALA 237.A O no hydrogen 2.490 N/A LEU 260.A N ILE 253.A O no hydrogen 2.919 N/A VAL 265.A N GLU 239.A OE2 no hydrogen 2.972 N/A THR 266.A N GLU 239.A OE1 no hydrogen 2.831 N/A THR 266.A OG1 GLU 239.A OE1 no hydrogen 2.775 N/A LYS 267.A N GLY 263.A O no hydrogen 3.069 N/A ARG 268.A N LEU 264.A O no hydrogen 2.864 N/A ALA 269.A N VAL 265.A O no hydrogen 2.908 N/A ARG 270.A N THR 266.A O no hydrogen 2.977 N/A ARG 270.A NE GLU 124.A OE1.A no hydrogen 3.109 N/A ARG 270.A NH1 SER 247.A O no hydrogen 3.007 N/A ARG 270.A NH1 VAL 249.A O no hydrogen 2.908 N/A ARG 270.A NH2 GLU 124.A OE2.A no hydrogen 2.744 N/A ALA 271.A N LYS 267.A O no hydrogen 2.835 N/A LEU 272.A N ARG 268.A O no hydrogen 2.752 N/A TYR 273.A N ALA 269.A O no hydrogen 3.015 N/A TRP 274.A N ARG 270.A O no hydrogen 3.074 N/A TRP 274.A NE1 GLU 40.A OE2 no hydrogen 2.939 N/A GLU 275.A N ALA 271.A O no hydrogen 2.991 N/A TRP 276.A N LEU 272.A O no hydrogen 3.152 N/A ALA 277.A N TYR 273.A O no hydrogen 2.872 N/A HIS 278.A N TRP 274.A O no hydrogen 3.075 N/A HIS 278.A N GLU 275.A O no hydrogen 3.233 N/A HIS 278.A NE2 GLU 40.A OE1 no hydrogen 2.772 N/A ALA 279.A N TRP 276.A O no hydrogen 3.089 N/A