Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4tw0_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 7.A N THR 181.A OG1 no hydrogen 2.818 N/A THR 11.A N ARG 8.A O no hydrogen 3.247 N/A THR 11.A OG1 ARG 8.A O no hydrogen 2.906 N/A PHE 14.A N THR 11.A OG1 no hydrogen 3.170 N/A ASP 15.A N THR 11.A O no hydrogen 2.661 N/A TRP 17.A N PHE 14.A O no hydrogen 2.959 N/A TYR 25.A N SER 378.A O no hydrogen 3.391 N/A TYR 25.A OH GLU 84.A OE2 no hydrogen 3.312 N/A THR 26.A N TYR 55.A O no hydrogen 3.006 N/A THR 26.A OG1 GLU 57.A OE2 no hydrogen 2.384 N/A GLN 27.A N ASN 376.A O no hydrogen 2.966 N/A PHE 28.A N TYR 53.A O no hydrogen 2.886 N/A TYR 29.A N TYR 374.A O no hydrogen 2.880 N/A PHE 30.A N VAL 50.A O no hydrogen 2.714 N/A PHE 31.A N VAL 372.A O no hydrogen 2.908 N/A ASN 32.A N GLU 48.A O no hydrogen 2.513 N/A VAL 33.A N ARG 98.A O no hydrogen 3.002 N/A THR 34.A N ARG 46.A O no hydrogen 3.044 N/A THR 34.A OG1 ARG 46.A O no hydrogen 2.686 N/A ASN 35.A ND2 THR 44.A O no hydrogen 3.331 N/A GLU 38.A N GLU 38.A OE1 no hydrogen 2.767 N/A ILE 39.A N ASN 35.A O no hydrogen 3.098 N/A LEU 40.A N PRO 36.A O no hydrogen 3.261 N/A ARG 41.A N GLU 37.A O no hydrogen 3.045 N/A GLY 42.A N ILE 39.A O no hydrogen 3.215 N/A GLU 43.A N GLU 38.A O no hydrogen 2.843 N/A ARG 46.A N ASN 35.A OD1 no hydrogen 2.682 N/A VAL 47.A N GLU 318.A O no hydrogen 3.364 N/A GLU 48.A N ASN 32.A O no hydrogen 2.785 N/A VAL 50.A N PHE 30.A O no hydrogen 2.771 N/A TYR 53.A N PHE 28.A O no hydrogen 2.850 N/A TYR 53.A OH ASP 95.A OD2 no hydrogen 3.153 N/A THR 54.A N SER 88.A OG no hydrogen 2.541 N/A THR 54.A OG1 GLN 87.A O no hydrogen 3.160 N/A TYR 55.A N THR 26.A O no hydrogen 2.761 N/A ARG 56.A N VAL 82.A O no hydrogen 2.755 N/A ARG 56.A NE TYR 25.A OH no hydrogen 3.411 N/A GLU 57.A N VAL 24.A O no hydrogen 3.061 N/A LEU 58.A N ALA 80.A O no hydrogen 3.100 N/A ASN 60.A N ASN 78.A O no hydrogen 3.224 N/A LYS 61.A N GLU 18.A O no hydrogen 3.262 N/A GLN 65.A N SER 74.A O no hydrogen 3.401 N/A GLY 67.A N THR 72.A O no hydrogen 3.272 N/A GLY 70.A N GLY 67.A O no hydrogen 2.917 N/A THR 71.A N ASP 68.A O no hydrogen 3.176 N/A ILE 73.A N PHE 179.A O no hydrogen 2.971 N/A SER 74.A N GLN 65.A O no hydrogen 3.336 N/A SER 74.A OG GLN 65.A O no hydrogen 3.467 N/A ALA 75.A N TYR 177.A O no hydrogen 3.067 N/A VAL 76.A N ALA 62.A O no hydrogen 3.007 N/A ASN 78.A N ASN 60.A O no hydrogen 3.290 N/A LYS 79.A N THR 172.A O no hydrogen 3.180 N/A LYS 79.A NZ GLU 57.A OE1 no hydrogen 3.164 N/A LYS 79.A NZ GLU 377.A OE2 no hydrogen 2.854 N/A ALA 80.A N LEU 58.A O no hydrogen 3.128 N/A TYR 81.A N ASN 170.A OD1 no hydrogen 2.847 N/A VAL 82.A N ARG 56.A O no hydrogen 2.803 N/A GLU 84.A N THR 54.A O no hydrogen 3.227 N/A ARG 85.A NH1 ARG 85.A O no hydrogen 3.496 N/A SER 88.A OG GLU 84.A O no hydrogen 2.871 N/A VAL 89.A N PRO 52.A O no hydrogen 2.872 N/A LYS 93.A N ASP 91.A OD2 no hydrogen 3.214 N/A ILE 94.A N ASP 91.A O no hydrogen 2.820 N/A ASP 95.A N ASP 91.A O no hydrogen 2.859 N/A ILE 97.A N HIS 135.A O no hydrogen 2.510 N/A ARG 98.A N ASN 32.A OD1 no hydrogen 2.772 N/A ARG 98.A NE VAL 33.A O no hydrogen 3.021 N/A ARG 98.A NH2 VAL 33.A O no hydrogen 2.798 N/A THR 99.A N VAL 133.A O no hydrogen 2.795 N/A ASN 101.A N LEU 131.A O no hydrogen 2.892 N/A ASN 101.A ND2 ASP 146.A OD2 no hydrogen 3.273 N/A VAL 104.A N ASN 101.A OD1 no hydrogen 3.435 N/A LEU 105.A N ASN 101.A O no hydrogen 3.355 N/A THR 106.A N ILE 102.A O no hydrogen 2.629 N/A THR 106.A OG1 ILE 102.A O no hydrogen 3.038 N/A VAL 107.A N PRO 103.A O no hydrogen 2.885 N/A ILE 108.A N VAL 104.A O no hydrogen 2.981 N/A GLU 109.A N LEU 105.A O no hydrogen 3.378 N/A TRP 110.A N THR 106.A O no hydrogen 2.669 N/A SER 111.A OG ILE 108.A O no hydrogen 2.790 N/A ARG 117.A N VAL 113.A O no hydrogen 2.682 N/A GLU 118.A N HIS 114.A O no hydrogen 2.965 N/A ILE 119.A N PHE 115.A O no hydrogen 2.897 N/A ILE 120.A N LEU 116.A O no hydrogen 2.752 N/A GLU 121.A N ARG 117.A O no hydrogen 2.960 N/A ALA 122.A N GLU 118.A O no hydrogen 3.173 N/A MET 123.A N ILE 119.A O no hydrogen 3.250 N/A LYS 125.A N GLU 121.A O no hydrogen 3.404 N/A ALA 126.A N ALA 122.A O no hydrogen 3.105 N/A TYR 127.A N MET 123.A O no hydrogen 2.862 N/A GLN 129.A N LEU 124.A O no hydrogen 3.093 N/A VAL 133.A N THR 99.A O no hydrogen 2.609 N/A HIS 135.A N ILE 97.A O no hydrogen 2.923 N/A VAL 137.A N ASP 95.A O no hydrogen 2.948 N/A ASP 138.A N PRO 92.A O no hydrogen 2.404 N/A GLU 139.A N THR 136.A O no hydrogen 2.591 N/A GLU 139.A N THR 136.A OG1 no hydrogen 3.064 N/A LEU 140.A N THR 136.A O no hydrogen 3.069 N/A LEU 141.A N VAL 137.A O no hydrogen 3.150 N/A TRP 142.A N ASP 138.A O no hydrogen 2.965 N/A TRP 142.A NE1 TYR 55.A OH no hydrogen 3.125 N/A TYR 144.A N PHE 163.A O no hydrogen 2.805 N/A ILE 148.A N ASP 146.A OD1 no hydrogen 2.987 N/A SER 150.A N ASP 146.A O no hydrogen 2.791 N/A LEU 151.A N ILE 148.A O no hydrogen 3.204 N/A ILE 152.A N ILE 148.A O no hydrogen 3.249 N/A HIS 153.A N LEU 149.A O no hydrogen 3.152 N/A PHE 155.A N ILE 152.A O no hydrogen 3.183 N/A ARG 156.A N ILE 152.A O no hydrogen 2.625 N/A ARG 156.A NE ASP 158.A OD1 no hydrogen 3.161 N/A ARG 156.A NE ASP 158.A OD2 no hydrogen 2.938 N/A ILE 159.A N ARG 156.A O no hydrogen 3.093 N/A PHE 163.A N TYR 144.A O no hydrogen 2.942 N/A LEU 165.A N LEU 140.A O no hydrogen 2.588 N/A PHE 166.A N LEU 141.A O no hydrogen 2.706 N/A GLY 171.A N LYS 79.A O no hydrogen 2.850 N/A THR 172.A OG1 GLU 168.A O no hydrogen 3.249 N/A ASN 173.A ND2 ASN 78.A OD1 no hydrogen 3.444 N/A GLY 175.A N ASN 173.A OD1 no hydrogen 2.898 N/A ASP 176.A N ASN 196.A OD1 no hydrogen 3.289 N/A TYR 177.A N ALA 75.A O no hydrogen 2.734 N/A TYR 177.A OH ASP 174.A OD1 no hydrogen 2.516 N/A TYR 177.A OH SER 235.A OG no hydrogen 2.429 N/A VAL 178.A N GLU 194.A O no hydrogen 3.019 N/A PHE 179.A N ILE 73.A O no hydrogen 2.644 N/A LEU 180.A N LYS 191.A O no hydrogen 2.952 N/A THR 181.A N THR 71.A O no hydrogen 3.069 N/A THR 181.A OG1 LEU 7.A O no hydrogen 2.800 N/A LEU 187.A N SER 185.A OG no hydrogen 3.387 N/A ASN 188.A ND2 ASP 184.A OD2 no hydrogen 2.690 N/A LYS 191.A N ASN 188.A O no hydrogen 3.071 N/A ILE 192.A N GLY 214.A O no hydrogen 3.201 N/A VAL 193.A N VAL 178.A O no hydrogen 3.418 N/A TRP 195.A N LYS 198.A O no hydrogen 3.018 N/A ASN 196.A N ASP 176.A O no hydrogen 3.095 N/A LYS 198.A N TRP 195.A O no hydrogen 2.782 N/A SER 200.A OG LEU 201.A O no hydrogen 3.439 N/A LEU 201.A N ASN 210.A O no hydrogen 2.647 N/A TRP 204.A N ASN 210.A OD1 no hydrogen 2.843 N/A ILE 205.A N GLY 274.A O no hydrogen 3.060 N/A LYS 208.A NZ ASP 271.A O no hydrogen 3.405 N/A CYS 209.A N THR 206.A OG1 no hydrogen 3.396 N/A CYS 209.A SG THR 206.A OG1 no hydrogen 2.478 N/A ASN 210.A N THR 206.A O no hydrogen 3.004 N/A ASN 210.A ND2 THR 206.A O no hydrogen 2.420 N/A MET 211.A N LYS 208.A O no hydrogen 3.153 N/A ASN 213.A N SER 240.A OG no hydrogen 3.323 N/A THR 215.A N TYR 231.A O no hydrogen 3.161 N/A THR 215.A OG1 SER 219.A O no hydrogen 2.840 N/A GLY 217.A N THR 215.A OG1 no hydrogen 2.672 N/A ASP 218.A N ASP 216.A OD1 no hydrogen 3.259 N/A PHE 220.A N GLY 338.A O no hydrogen 3.069 N/A LEU 223.A N LEU 336.A O no hydrogen 2.742 N/A THR 225.A N GLU 228.A OE1 no hydrogen 2.755 N/A THR 225.A OG1 GLU 228.A OE1 no hydrogen 2.899 N/A LEU 230.A N ILE 243.A O no hydrogen 3.263 N/A VAL 232.A N VAL 241.A O no hydrogen 2.621 N/A PHE 233.A N THR 215.A O no hydrogen 2.871 N/A SER 235.A OG TYR 177.A OH no hydrogen 2.429 N/A CYS 238.A N SER 235.A O no hydrogen 2.819 N/A CYS 238.A SG ASP 236.A O no hydrogen 3.973 N/A ARG 239.A NE SER 240.A O no hydrogen 3.114 N/A ARG 239.A NH1 SER 240.A O no hydrogen 3.154 N/A ARG 239.A NH2 ILE 265.A O no hydrogen 2.984 N/A SER 240.A OG MET 211.A O no hydrogen 2.859 N/A VAL 241.A N VAL 232.A O no hydrogen 2.708 N/A ILE 243.A N LEU 230.A O no hydrogen 2.871 N/A THR 244.A N LYS 260.A O no hydrogen 3.158 N/A SER 246.A N ARG 258.A O no hydrogen 2.686 N/A GLU 249.A N ALA 256.A O no hydrogen 2.860 N/A VAL 251.A N LEU 254.A O no hydrogen 3.266 N/A GLN 252.A NE2 ILE 381.A O no hydrogen 3.496 N/A LEU 254.A N VAL 251.A O no hydrogen 3.182 N/A ALA 256.A N GLU 249.A O no hydrogen 2.481 N/A PHE 257.A N ILE 333.A O no hydrogen 2.825 N/A ARG 258.A N ASP 247.A O no hydrogen 2.845 N/A ARG 258.A NE ASP 332.A OD1 no hydrogen 3.295 N/A TYR 259.A N VAL 331.A O no hydrogen 2.840 N/A TYR 259.A OH GLU 228.A O no hydrogen 3.034 N/A LEU 266.A N ALA 263.A O no hydrogen 3.160 N/A ASN 268.A N SER 285.A OG no hydrogen 3.229 N/A ASN 272.A ND2 GLU 264.A O no hydrogen 2.618 N/A ASN 272.A ND2 ALA 267.A O no hydrogen 3.397 N/A PHE 275.A N ASN 272.A O no hydrogen 3.262 N/A CYS 276.A N ALA 273.A O no hydrogen 3.216 N/A CYS 276.A SG ALA 273.A O no hydrogen 3.610 N/A GLU 279.A N ILE 277.A O no hydrogen 2.416 N/A ASN 281.A N PRO 278.A O no hydrogen 3.049 N/A CYS 282.A SG ASN 268.A OD1 no hydrogen 3.571 N/A GLY 286.A N LEU 266.A O no hydrogen 2.572 N/A LEU 288.A N MET 301.A O no hydrogen 2.795 N/A VAL 290.A N ILE 299.A O no hydrogen 3.198 N/A SER 291.A N ASN 289.A OD1 no hydrogen 3.200 N/A SER 291.A OG ASN 289.A OD1 no hydrogen 2.631 N/A CYS 293.A SG VAL 290.A O no hydrogen 3.303 N/A LYS 294.A N VAL 290.A O no hydrogen 3.125 N/A LYS 294.A NZ ASP 236.A OD2 no hydrogen 3.391 N/A ILE 299.A N ALA 297.A O no hydrogen 2.871 N/A ILE 300.A N ASN 350.A O no hydrogen 2.790 N/A SER 302.A N GLN 348.A O no hydrogen 3.413 N/A HIS 305.A N GLN 348.A OE1 no hydrogen 2.542 N/A PHE 306.A N PHE 303.A O no hydrogen 2.718 N/A TYR 307.A N PRO 304.A O no hydrogen 3.280 N/A GLN 308.A NE2 PRO 262.A O no hydrogen 3.066 N/A ALA 309.A N PHE 306.A O no hydrogen 2.765 N/A ASP 310.A N SER 285.A O no hydrogen 2.865 N/A ARG 312.A NH2 LEU 283.A O no hydrogen 3.076 N/A PHE 313.A N ASP 310.A O no hydrogen 2.709 N/A SER 315.A N GLU 311.A O no hydrogen 2.773 N/A SER 315.A OG GLU 311.A O no hydrogen 2.786 N/A ALA 316.A N PHE 313.A O no hydrogen 3.057 N/A GLU 318.A N PRO 45.A O no hydrogen 3.275 N/A HIS 321.A N HIS 305.A ND1 no hydrogen 3.018 N/A ASN 323.A N HIS 327.A ND1 no hydrogen 3.133 N/A GLN 324.A NE2 GLU 328.A OE1 no hydrogen 3.307 N/A ASP 326.A N ASN 323.A OD1 no hydrogen 2.691 N/A HIS 327.A N ASN 323.A O no hydrogen 2.983 N/A GLU 328.A N GLN 324.A O no hydrogen 3.276 N/A VAL 331.A N TYR 259.A O no hydrogen 2.830 N/A ASP 332.A N LYS 342.A O no hydrogen 2.567 N/A ILE 333.A N PHE 257.A O no hydrogen 3.264 N/A ASN 334.A N ILE 339.A O no hydrogen 2.750 N/A ASN 334.A ND2 PRO 255.A O no hydrogen 3.576 N/A THR 337.A N ASN 334.A OD1 no hydrogen 2.948 N/A THR 337.A OG1 ASN 334.A OD1 no hydrogen 2.960 N/A GLY 338.A N ASN 334.A O no hydrogen 2.889 N/A ILE 339.A N THR 337.A OG1 no hydrogen 3.056 N/A LEU 341.A N ASP 332.A O no hydrogen 2.838 N/A ALA 343.A N VAL 379.A O no hydrogen 3.239 N/A ALA 344.A N PHE 330.A O no hydrogen 3.305 N/A LYS 345.A N GLU 377.A O no hydrogen 2.545 N/A ARG 346.A N THR 329.A OG1 no hydrogen 3.212 N/A ARG 346.A NE GLU 328.A O no hydrogen 2.835 N/A GLN 348.A N SER 302.A O no hydrogen 2.495 N/A GLN 348.A NE2 ASN 350.A OD1 no hydrogen 3.251 N/A ILE 349.A N MET 373.A O no hydrogen 2.792 N/A ASN 350.A N ILE 300.A O no hydrogen 2.830 N/A ASN 350.A ND2 ILE 300.A O no hydrogen 2.768 N/A ASN 350.A ND2 SER 302.A OG no hydrogen 2.493 N/A ILE 351.A N PHE 370.A O no hydrogen 2.612 N/A TYR 352.A N PRO 298.A O no hydrogen 3.084 N/A VAL 353.A N MET 368.A O no hydrogen 3.083 N/A LYS 355.A NZ GLY 363.A O no hydrogen 3.470 N/A LEU 356.A N THR 362.A OG1 no hydrogen 3.062 N/A THR 362.A N PHE 359.A O no hydrogen 3.424 N/A THR 362.A OG1 PHE 359.A O no hydrogen 2.926 N/A ASP 364.A N LEU 40.A O no hydrogen 2.862 N/A ILE 365.A N THR 362.A O no hydrogen 3.414 N/A MET 368.A N VAL 353.A O no hydrogen 2.945 N/A PHE 370.A N ILE 351.A O no hydrogen 3.120 N/A VAL 372.A N ILE 349.A O no hydrogen 2.745 N/A MET 373.A N ILE 349.A O no hydrogen 3.323 N/A TYR 374.A N TYR 29.A O no hydrogen 2.978 N/A TYR 374.A OH GLU 49.A OE1 no hydrogen 3.181 N/A LEU 375.A N PHE 347.A O no hydrogen 3.276 N/A ASN 376.A N GLN 27.A O no hydrogen 2.986 N/A GLU 377.A N LYS 345.A O no hydrogen 2.607 N/A SER 378.A N TYR 25.A O no hydrogen 2.712 N/A SER 378.A OG TYR 25.A O no hydrogen 2.900 N/A THR 385.A N ASP 382.A OD2 no hydrogen 3.330 N/A ALA 386.A N LYS 383.A O no hydrogen 3.094 N/A SER 387.A N LYS 383.A O no hydrogen 3.471 N/A SER 387.A OG GLU 384.A O no hydrogen 3.252 N/A LEU 389.A N THR 385.A O no hydrogen 3.329 N/A LYS 390.A N ALA 386.A O no hydrogen 2.834 N/A SER 391.A N SER 387.A O no hydrogen 2.567 N/A MET 392.A N ARG 388.A O no hydrogen 3.164 N/A ILE 393.A N LEU 389.A O no hydrogen 3.005 N/A