Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4tw2_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 7.A N THR 181.A OG1 no hydrogen 2.545 N/A THR 11.A N ARG 8.A O no hydrogen 3.062 N/A THR 11.A OG1 LYS 4.A O no hydrogen 2.721 N/A SER 16.A N GLU 12.A O no hydrogen 3.486 N/A TRP 17.A N ALA 13.A O no hydrogen 2.704 N/A GLU 18.A N PHE 14.A O no hydrogen 2.763 N/A LYS 19.A N ASP 15.A O no hydrogen 2.908 N/A TYR 25.A N SER 378.A O no hydrogen 2.842 N/A THR 26.A N TYR 55.A O no hydrogen 2.903 N/A THR 26.A OG1 GLU 57.A OE2 no hydrogen 2.170 N/A GLN 27.A N ASN 376.A O no hydrogen 3.029 N/A PHE 28.A N TYR 53.A O no hydrogen 3.029 N/A TYR 29.A N TYR 374.A O no hydrogen 2.810 N/A PHE 30.A N VAL 50.A O no hydrogen 2.795 N/A PHE 31.A N VAL 372.A O no hydrogen 2.803 N/A ASN 32.A N GLU 48.A O no hydrogen 2.731 N/A VAL 33.A N ARG 98.A O no hydrogen 2.769 N/A THR 34.A N ARG 46.A O no hydrogen 2.900 N/A THR 34.A OG1 ARG 46.A O no hydrogen 2.889 N/A ASN 35.A ND2 THR 44.A O no hydrogen 2.853 N/A GLU 38.A N GLU 38.A OE1 no hydrogen 2.701 N/A ILE 39.A N ASN 35.A O no hydrogen 3.009 N/A LEU 40.A N PRO 36.A O no hydrogen 3.012 N/A ARG 41.A N GLU 37.A O no hydrogen 3.276 N/A ARG 41.A N GLU 38.A O no hydrogen 3.231 N/A GLY 42.A N ILE 39.A O no hydrogen 2.821 N/A GLU 43.A N GLU 38.A O no hydrogen 2.897 N/A ARG 46.A N ASN 35.A OD1 no hydrogen 2.793 N/A VAL 47.A N GLU 318.A O no hydrogen 3.117 N/A GLU 48.A N ASN 32.A O no hydrogen 2.786 N/A VAL 50.A N PHE 30.A O no hydrogen 2.710 N/A TYR 53.A N PHE 28.A O no hydrogen 3.021 N/A TYR 53.A OH ASP 95.A OD2 no hydrogen 2.541 N/A THR 54.A N SER 88.A OG no hydrogen 2.583 N/A THR 54.A OG1 GLN 27.A OE1 no hydrogen 3.522 N/A THR 54.A OG1 GLN 87.A O no hydrogen 2.737 N/A TYR 55.A N THR 26.A O no hydrogen 3.021 N/A ARG 56.A N VAL 82.A O no hydrogen 2.787 N/A ARG 56.A NE GLU 84.A OE2 no hydrogen 3.006 N/A GLU 57.A N VAL 24.A O no hydrogen 2.728 N/A LEU 58.A N ALA 80.A O no hydrogen 2.856 N/A ARG 59.A NE GLU 57.A OE1 no hydrogen 2.724 N/A ARG 59.A NH1 ASP 218.A OD1 no hydrogen 3.054 N/A ARG 59.A NH2 GLU 57.A OE1 no hydrogen 2.722 N/A LYS 61.A N GLU 18.A O no hydrogen 3.011 N/A LYS 61.A NZ TRP 17.A O no hydrogen 2.892 N/A ALA 62.A N VAL 76.A O no hydrogen 2.935 N/A GLN 65.A N SER 74.A O no hydrogen 3.043 N/A GLY 67.A N THR 72.A O no hydrogen 2.913 N/A GLY 70.A N GLY 67.A O no hydrogen 3.425 N/A THR 71.A N ASP 68.A O no hydrogen 2.883 N/A THR 71.A OG1 ASP 68.A O no hydrogen 2.443 N/A THR 72.A N GLY 67.A O no hydrogen 3.050 N/A ILE 73.A N PHE 179.A O no hydrogen 2.660 N/A SER 74.A N GLN 65.A O no hydrogen 2.838 N/A ALA 75.A N TYR 177.A O no hydrogen 2.816 N/A VAL 76.A N ALA 62.A O no hydrogen 2.935 N/A ASN 78.A N ASN 60.A O no hydrogen 3.072 N/A LYS 79.A N THR 172.A O no hydrogen 3.071 N/A LYS 79.A NZ GLU 377.A OE2 no hydrogen 3.540 N/A ALA 80.A N LEU 58.A O no hydrogen 3.116 N/A TYR 81.A N ASN 170.A OD1 no hydrogen 2.763 N/A VAL 82.A N ARG 56.A O no hydrogen 2.802 N/A GLU 84.A N THR 54.A O no hydrogen 2.828 N/A ARG 85.A NH1 ARG 85.A O no hydrogen 3.019 N/A SER 88.A N ARG 85.A O no hydrogen 3.004 N/A SER 88.A OG GLU 84.A O no hydrogen 2.537 N/A VAL 89.A N PRO 52.A O no hydrogen 2.763 N/A ILE 94.A N ASP 91.A O no hydrogen 2.941 N/A ASP 95.A N ASP 91.A O no hydrogen 2.780 N/A ILE 97.A N HIS 135.A O no hydrogen 2.885 N/A ARG 98.A N ASN 32.A OD1 no hydrogen 2.727 N/A ARG 98.A NE VAL 33.A O no hydrogen 3.175 N/A ARG 98.A NH2 VAL 33.A O no hydrogen 3.528 N/A THR 99.A N VAL 133.A O no hydrogen 3.002 N/A LEU 100.A N THR 99.A OG1 no hydrogen 2.596 N/A ASN 101.A N LEU 131.A O no hydrogen 2.448 N/A ASN 101.A ND2 LYS 130.A O no hydrogen 3.372 N/A VAL 104.A N ASN 101.A OD1 no hydrogen 3.427 N/A LEU 105.A N ASN 101.A O no hydrogen 3.311 N/A THR 106.A N ILE 102.A O no hydrogen 2.893 N/A THR 106.A OG1 ILE 102.A O no hydrogen 2.448 N/A VAL 107.A N PRO 103.A O no hydrogen 2.992 N/A ILE 108.A N VAL 104.A O no hydrogen 3.006 N/A GLU 109.A N LEU 105.A O no hydrogen 3.130 N/A TRP 110.A N THR 106.A O no hydrogen 2.889 N/A TRP 110.A NE1 ASN 295.A O no hydrogen 3.015 N/A SER 111.A N ILE 108.A O no hydrogen 2.755 N/A SER 111.A OG ILE 108.A O no hydrogen 2.514 N/A GLN 112.A N ILE 108.A O no hydrogen 3.028 N/A PHE 115.A N TRP 110.A O no hydrogen 3.326 N/A GLU 118.A N HIS 114.A ND1 no hydrogen 2.638 N/A MET 123.A N ILE 120.A O no hydrogen 2.875 N/A LYS 125.A N GLU 121.A O no hydrogen 3.309 N/A ALA 126.A N ALA 122.A O no hydrogen 2.908 N/A TYR 127.A N MET 123.A O no hydrogen 2.624 N/A VAL 133.A N THR 99.A O no hydrogen 2.727 N/A HIS 135.A N ILE 97.A O no hydrogen 3.289 N/A THR 136.A N GLU 139.A OE1 no hydrogen 3.225 N/A VAL 137.A N ASP 95.A O no hydrogen 3.157 N/A ASP 138.A N PRO 92.A O no hydrogen 2.944 N/A GLU 139.A N THR 136.A OG1 no hydrogen 2.943 N/A LEU 140.A N THR 136.A O no hydrogen 2.858 N/A LEU 141.A N VAL 137.A O no hydrogen 2.901 N/A TRP 142.A N ASP 138.A O no hydrogen 2.924 N/A TRP 142.A NE1 TYR 55.A OH no hydrogen 3.198 N/A GLY 143.A N GLU 139.A O no hydrogen 2.961 N/A TYR 144.A N PHE 163.A O no hydrogen 2.925 N/A ASP 146.A N PRO 161.A O no hydrogen 3.009 N/A LEU 149.A N ASP 146.A OD1 no hydrogen 2.759 N/A SER 150.A N ASP 146.A O no hydrogen 2.956 N/A SER 150.A OG ASP 146.A O no hydrogen 2.146 N/A LEU 151.A N GLU 147.A O no hydrogen 3.141 N/A ILE 152.A N ILE 148.A O no hydrogen 3.136 N/A HIS 153.A N LEU 149.A O no hydrogen 2.869 N/A HIS 153.A ND1 ILE 159.A O no hydrogen 3.079 N/A ARG 156.A N ILE 152.A O no hydrogen 2.593 N/A ARG 156.A NE ASP 158.A OD1 no hydrogen 2.656 N/A ARG 156.A NE ASP 158.A OD2 no hydrogen 3.325 N/A ARG 156.A NH2 ASP 158.A OD2 no hydrogen 3.083 N/A ILE 159.A N ARG 156.A O no hydrogen 2.873 N/A SER 160.A OG TYR 162.A O no hydrogen 3.531 N/A TYR 162.A N SER 160.A OG no hydrogen 3.119 N/A PHE 163.A N TYR 144.A O no hydrogen 2.998 N/A LEU 165.A N LEU 140.A O no hydrogen 2.922 N/A PHE 166.A N LEU 141.A O no hydrogen 2.738 N/A TYR 167.A N GLY 164.A O no hydrogen 3.288 N/A LYS 169.A N PHE 166.A O no hydrogen 2.824 N/A GLY 171.A N LYS 79.A O no hydrogen 2.858 N/A THR 172.A OG1 GLU 168.A O no hydrogen 3.213 N/A ASN 173.A ND2 ASN 78.A OD1 no hydrogen 3.208 N/A ASP 174.A N ASP 174.A OD1 no hydrogen 2.556 N/A GLY 175.A N ASN 173.A OD1 no hydrogen 2.806 N/A ASP 176.A N ASN 196.A OD1 no hydrogen 3.063 N/A TYR 177.A N ALA 75.A O no hydrogen 3.052 N/A TYR 177.A OH ASP 174.A OD2 no hydrogen 2.772 N/A PHE 179.A N ILE 73.A O no hydrogen 2.395 N/A LEU 180.A N LYS 191.A O no hydrogen 2.559 N/A THR 181.A N THR 71.A O no hydrogen 2.839 N/A THR 181.A OG1 LEU 7.A O no hydrogen 3.347 N/A GLY 182.A N THR 181.A OG1 no hydrogen 2.675 N/A SER 185.A N ASP 184.A OD1 no hydrogen 2.717 N/A LEU 187.A N SER 185.A OG no hydrogen 3.127 N/A ASN 188.A N SER 185.A O no hydrogen 3.275 N/A PHE 189.A N TYR 186.A O no hydrogen 3.290 N/A THR 190.A OG1 THR 190.A O no hydrogen 2.678 N/A LYS 191.A N LEU 180.A O no hydrogen 3.150 N/A LYS 191.A N ASN 188.A O no hydrogen 3.270 N/A ILE 192.A N GLY 214.A O no hydrogen 3.146 N/A VAL 193.A N VAL 178.A O no hydrogen 3.340 N/A TRP 195.A N LYS 198.A O no hydrogen 3.037 N/A TRP 195.A NE1 ASP 174.A O no hydrogen 3.035 N/A ASN 196.A N ASP 176.A O no hydrogen 2.675 N/A LYS 198.A N TRP 195.A O no hydrogen 3.055 N/A LYS 198.A NZ ASP 202.A OD2 no hydrogen 2.749 N/A LEU 201.A N ASN 210.A O no hydrogen 2.834 N/A TRP 204.A N ASN 210.A OD1 no hydrogen 2.742 N/A TRP 204.A NE1 CYS 238.A O no hydrogen 2.798 N/A ILE 205.A N GLY 274.A O no hydrogen 3.116 N/A CYS 209.A N THR 206.A OG1 no hydrogen 2.818 N/A CYS 209.A SG THR 206.A OG1 no hydrogen 2.959 N/A CYS 209.A SG ASP 271.A O no hydrogen 3.462 N/A ASN 210.A N THR 206.A O no hydrogen 3.294 N/A ASN 210.A N ASP 207.A O no hydrogen 3.260 N/A ASN 210.A ND2 TRP 204.A O no hydrogen 2.412 N/A MET 211.A N LYS 208.A O no hydrogen 3.148 N/A ASN 213.A N SER 240.A OG no hydrogen 2.996 N/A THR 215.A N TYR 231.A O no hydrogen 3.120 N/A THR 215.A OG1 SER 219.A O no hydrogen 2.764 N/A GLY 217.A N THR 215.A OG1 no hydrogen 3.087 N/A ASP 218.A N ASP 216.A OD2 no hydrogen 3.376 N/A PHE 220.A N GLY 338.A O no hydrogen 3.186 N/A HIS 221.A NE2 GLU 228.A OE2 no hydrogen 2.846 N/A LEU 223.A N LEU 336.A O no hydrogen 2.836 N/A ILE 224.A N PRO 335.A O no hydrogen 2.889 N/A THR 225.A N GLU 228.A OE1 no hydrogen 2.509 N/A THR 225.A OG1 ASP 227.A OD2 no hydrogen 2.634 N/A THR 225.A OG1 GLU 228.A OE1 no hydrogen 2.485 N/A LYS 226.A NZ TYR 248.A OH no hydrogen 3.361 N/A GLU 228.A N THR 225.A O no hydrogen 3.054 N/A LEU 230.A N ILE 243.A O no hydrogen 3.113 N/A VAL 232.A N VAL 241.A O no hydrogen 2.628 N/A PHE 233.A N THR 215.A O no hydrogen 2.636 N/A PHE 237.A N PRO 234.A O no hydrogen 2.665 N/A CYS 238.A N SER 235.A O no hydrogen 2.785 N/A CYS 238.A SG SER 235.A O no hydrogen 3.697 N/A CYS 238.A SG ASP 236.A O no hydrogen 3.744 N/A ARG 239.A NE SER 240.A O no hydrogen 2.963 N/A ARG 239.A NH1 SER 240.A O no hydrogen 3.094 N/A ARG 239.A NH2 ILE 265.A O no hydrogen 3.176 N/A SER 240.A OG MET 211.A O no hydrogen 2.956 N/A VAL 241.A N VAL 232.A O no hydrogen 2.870 N/A ILE 243.A N LEU 230.A O no hydrogen 2.779 N/A THR 244.A N LYS 260.A O no hydrogen 2.949 N/A SER 246.A N ARG 258.A O no hydrogen 2.615 N/A SER 246.A OG ASP 247.A OD1 no hydrogen 2.795 N/A SER 246.A OG ASP 247.A OD2 no hydrogen 2.951 N/A ASP 247.A N ARG 258.A O no hydrogen 3.423 N/A GLU 249.A N ALA 256.A O no hydrogen 2.526 N/A VAL 251.A N LEU 254.A O no hydrogen 2.888 N/A LEU 254.A N VAL 251.A O no hydrogen 2.998 N/A ALA 256.A N GLU 249.A O no hydrogen 2.545 N/A PHE 257.A N ILE 333.A O no hydrogen 2.852 N/A ARG 258.A N ASP 247.A O no hydrogen 2.805 N/A ARG 258.A NE ASP 332.A OD1 no hydrogen 2.420 N/A ARG 258.A NE ASP 332.A OD2 no hydrogen 3.316 N/A ARG 258.A NH2 ASP 332.A OD2 no hydrogen 3.153 N/A TYR 259.A N VAL 331.A O no hydrogen 2.797 N/A TYR 259.A OH GLU 228.A O no hydrogen 2.854 N/A LYS 260.A N THR 244.A O no hydrogen 3.004 N/A LYS 260.A NZ GLU 328.A OE1 no hydrogen 3.032 N/A VAL 261.A N THR 329.A O no hydrogen 3.024 N/A GLU 264.A N GLU 264.A OE1 no hydrogen 2.760 N/A ILE 265.A N PRO 262.A O no hydrogen 3.426 N/A ASN 268.A N SER 285.A OG no hydrogen 2.633 N/A ASN 272.A ND2 GLU 264.A O no hydrogen 2.684 N/A ASN 272.A ND2 ALA 267.A O no hydrogen 3.039 N/A ALA 273.A N SER 270.A O no hydrogen 3.171 N/A PHE 275.A N ASN 272.A O no hydrogen 3.030 N/A CYS 276.A N ALA 273.A O no hydrogen 3.155 N/A CYS 276.A SG ASN 272.A O no hydrogen 3.780 N/A CYS 282.A SG ASN 268.A OD1 no hydrogen 3.124 N/A SER 285.A N ASP 310.A OD2 no hydrogen 3.296 N/A GLY 286.A N LEU 266.A O no hydrogen 2.717 N/A LEU 288.A N MET 301.A O no hydrogen 2.855 N/A VAL 290.A N ILE 299.A O no hydrogen 3.294 N/A SER 291.A N ASN 289.A OD1 no hydrogen 3.075 N/A SER 291.A OG ALA 297.A O no hydrogen 3.176 N/A CYS 293.A SG VAL 290.A O no hydrogen 3.031 N/A LYS 294.A N VAL 290.A O no hydrogen 3.022 N/A LYS 294.A N SER 291.A O no hydrogen 3.287 N/A LYS 294.A NZ ASP 236.A O no hydrogen 3.079 N/A GLY 296.A N SER 291.A O no hydrogen 2.845 N/A ILE 299.A N ALA 297.A O no hydrogen 2.732 N/A ILE 300.A N ASN 350.A O no hydrogen 2.801 N/A MET 301.A N LEU 288.A O no hydrogen 2.835 N/A SER 302.A N GLN 348.A O no hydrogen 3.174 N/A SER 302.A OG PHE 303.A O no hydrogen 3.046 N/A HIS 305.A N GLN 348.A OE1 no hydrogen 2.750 N/A HIS 305.A NE2 GLU 49.A OE1 no hydrogen 2.851 N/A PHE 306.A N PHE 303.A O no hydrogen 2.954 N/A TYR 307.A N PRO 304.A O no hydrogen 3.058 N/A GLN 308.A NE2 VAL 261.A O no hydrogen 3.173 N/A ASP 310.A N SER 285.A O no hydrogen 2.916 N/A ARG 312.A NH2 LEU 283.A O no hydrogen 2.412 N/A PHE 313.A N ASP 310.A O no hydrogen 3.091 N/A SER 315.A N GLU 311.A O no hydrogen 2.744 N/A SER 315.A OG GLU 311.A O no hydrogen 3.010 N/A ALA 316.A N ARG 312.A O no hydrogen 3.090 N/A ILE 317.A N VAL 314.A O no hydrogen 3.358 N/A GLU 318.A N PRO 45.A O no hydrogen 2.770 N/A HIS 321.A N HIS 305.A ND1 no hydrogen 3.135 N/A ASN 323.A N HIS 327.A ND1 no hydrogen 3.016 N/A ASN 323.A ND2 ASP 326.A OD2 no hydrogen 2.951 N/A ASP 326.A N ASN 323.A OD1 no hydrogen 2.864 N/A HIS 327.A N ASN 323.A O no hydrogen 2.997 N/A GLU 328.A N GLN 324.A O no hydrogen 2.966 N/A PHE 330.A N ALA 344.A O no hydrogen 3.053 N/A VAL 331.A N TYR 259.A O no hydrogen 2.601 N/A ASP 332.A N LYS 342.A O no hydrogen 2.623 N/A ILE 333.A N PHE 257.A O no hydrogen 2.942 N/A ASN 334.A N ILE 339.A O no hydrogen 2.746 N/A ASN 334.A ND2 PRO 255.A O no hydrogen 3.493 N/A THR 337.A N ASN 334.A OD1 no hydrogen 2.867 N/A THR 337.A OG1 ASN 334.A OD1 no hydrogen 2.403 N/A LEU 341.A N ASP 332.A O no hydrogen 2.861 N/A ALA 343.A N VAL 379.A O no hydrogen 3.143 N/A ALA 344.A N PHE 330.A O no hydrogen 3.007 N/A LYS 345.A N GLU 377.A O no hydrogen 2.835 N/A LYS 345.A NZ GLY 217.A O no hydrogen 2.822 N/A ARG 346.A N THR 329.A OG1 no hydrogen 3.066 N/A ARG 346.A NE GLU 328.A O no hydrogen 2.634 N/A ARG 346.A NH2 GLU 328.A O no hydrogen 2.908 N/A GLN 348.A N SER 302.A O no hydrogen 2.532 N/A GLN 348.A NE2 ASN 350.A OD1 no hydrogen 2.577 N/A ILE 349.A N MET 373.A O no hydrogen 2.599 N/A ASN 350.A N ILE 300.A O no hydrogen 2.901 N/A ASN 350.A ND2 ILE 300.A O no hydrogen 2.988 N/A ASN 350.A ND2 SER 302.A OG no hydrogen 2.771 N/A ILE 351.A N PHE 370.A O no hydrogen 2.628 N/A TYR 352.A N PRO 298.A O no hydrogen 3.003 N/A VAL 353.A N MET 368.A O no hydrogen 3.151 N/A LYS 355.A NZ ASP 357.A OD1 no hydrogen 3.135 N/A LYS 355.A NZ GLY 363.A O no hydrogen 3.478 N/A LEU 356.A N THR 362.A OG1 no hydrogen 2.762 N/A PHE 359.A N LEU 356.A O no hydrogen 3.277 N/A GLU 361.A N GLU 361.A OE1 no hydrogen 2.854 N/A THR 362.A N PHE 359.A O no hydrogen 3.142 N/A THR 362.A OG1 LEU 356.A O no hydrogen 2.685 N/A THR 362.A OG1 PHE 359.A O no hydrogen 2.667 N/A GLY 363.A N VAL 360.A O no hydrogen 2.961 N/A ASP 364.A N LEU 40.A O no hydrogen 2.799 N/A ILE 365.A N THR 362.A O no hydrogen 3.062 N/A ARG 366.A NE GLY 42.A O no hydrogen 2.658 N/A ARG 366.A NH2 GLY 42.A O no hydrogen 3.368 N/A MET 368.A N VAL 353.A O no hydrogen 3.117 N/A PHE 370.A N ILE 351.A O no hydrogen 2.665 N/A VAL 372.A N ILE 349.A O no hydrogen 3.011 N/A MET 373.A N ILE 349.A O no hydrogen 3.342 N/A TYR 374.A N TYR 29.A O no hydrogen 2.893 N/A TYR 374.A OH GLU 49.A OE1 no hydrogen 3.095 N/A LEU 375.A N PHE 347.A O no hydrogen 3.190 N/A ASN 376.A N GLN 27.A O no hydrogen 2.996 N/A GLU 377.A N LYS 345.A O no hydrogen 2.837 N/A SER 378.A N TYR 25.A O no hydrogen 2.739 N/A SER 378.A OG TYR 25.A O no hydrogen 3.391 N/A VAL 379.A N ALA 343.A O no hydrogen 3.272 N/A HIS 380.A ND1 ILE 381.A O no hydrogen 3.001 N/A ILE 381.A N LEU 341.A O no hydrogen 2.968 N/A THR 385.A N ASP 382.A OD2 no hydrogen 2.896 N/A THR 385.A OG1 ASP 382.A O no hydrogen 3.218 N/A THR 385.A OG1 ASP 382.A OD1 no hydrogen 2.614 N/A ALA 386.A N ASP 382.A O no hydrogen 3.102 N/A SER 387.A N LYS 383.A O no hydrogen 2.680 N/A SER 387.A OG LYS 383.A O no hydrogen 3.109 N/A ARG 388.A N GLU 384.A O no hydrogen 3.373 N/A LEU 389.A N THR 385.A O no hydrogen 2.871 N/A LYS 390.A N ALA 386.A O no hydrogen 2.742 N/A SER 391.A N SER 387.A O no hydrogen 3.017 N/A SER 391.A OG SER 387.A O no hydrogen 3.254 N/A SER 391.A OG ARG 388.A O no hydrogen 3.085 N/A MET 392.A N ARG 388.A O no hydrogen 3.076 N/A ILE 393.A N LEU 389.A O no hydrogen 3.067 N/A ASN 394.A N SER 391.A O no hydrogen 3.088 N/A