Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4wc2_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLN 4.A NE2 GLU 8.A OE2 no hydrogen 2.684 N/A ILE 5.A N MET 1.A O no hydrogen 3.079 N/A ALA 6.A N VAL 2.A O no hydrogen 2.884 N/A LYS 7.A N GLY 3.A O no hydrogen 2.925 N/A GLU 8.A N GLN 4.A O no hydrogen 2.918 N/A MET 9.A N ILE 5.A O no hydrogen 3.019 N/A GLY 10.A N LYS 7.A O no hydrogen 3.172 N/A LEU 11.A N ALA 6.A O no hydrogen 2.753 N/A ARG 12.A NE TYR 14.A OH no hydrogen 2.866 N/A ARG 12.A NH1 GLU 108.A OE2 no hydrogen 3.032 N/A ARG 12.A NH2 TYR 14.A OH no hydrogen 3.174 N/A ARG 12.A NH2 ASP 109.A OD2 no hydrogen 3.122 N/A ALA 13.A N ASN 106.A OD1 no hydrogen 2.534 N/A TYR 14.A N VAL 35.A O no hydrogen 2.913 N/A ILE 15.A N ILE 103.A O no hydrogen 2.885 N/A VAL 16.A N ASP 33.A O no hydrogen 2.900 N/A GLY 17.A N MET 101.A O no hydrogen 3.256 N/A VAL 20.A N GLY 17.A O no hydrogen 2.921 N/A ARG 21.A N GLY 17.A O no hydrogen 3.390 N/A ARG 21.A NE ASP 22.A OD1 no hydrogen 3.344 N/A ARG 21.A NH1 ASN 99.A OD1 no hydrogen 2.396 N/A ARG 21.A NH2 ASP 22.A OD1 no hydrogen 3.219 N/A ARG 21.A NH2 ASP 22.A OD2 no hydrogen 3.519 N/A ASP 22.A N GLY 18.A O no hydrogen 2.827 N/A ILE 23.A N VAL 19.A O no hydrogen 3.084 N/A LEU 24.A N VAL 20.A O no hydrogen 2.954 N/A LEU 25.A N ARG 21.A O no hydrogen 2.817 N/A GLY 26.A N ILE 23.A O no hydrogen 2.885 N/A LYS 27.A N ASP 22.A O no hydrogen 2.539 N/A VAL 32.A N LYS 72.A O no hydrogen 2.884 N/A PHE 34.A N GLU 74.A O no hydrogen 2.663 N/A VAL 35.A N TYR 14.A O no hydrogen 2.874 N/A VAL 36.A N ALA 76.A O no hydrogen 2.807 N/A GLU 37.A N ARG 12.A O no hydrogen 2.920 N/A GLU 42.A N ASN 39.A OD1 no hydrogen 2.657 N/A ALA 44.A N ALA 40.A O no hydrogen 2.919 N/A LYS 45.A N ILE 41.A O no hydrogen 2.884 N/A GLU 46.A N GLU 42.A O no hydrogen 2.912 N/A LEU 47.A N LEU 43.A O no hydrogen 2.920 N/A ALA 48.A N ALA 44.A O no hydrogen 2.898 N/A ARG 49.A N LYS 45.A O no hydrogen 2.906 N/A ARG 49.A NE GLU 46.A OE1 no hydrogen 3.484 N/A ARG 49.A NH2 GLU 46.A OE2 no hydrogen 2.721 N/A ARG 50.A N GLU 46.A O no hydrogen 2.895 N/A ARG 50.A NE GLU 46.A OE2 no hydrogen 3.200 N/A ARG 50.A NH1 GLU 8.A OE2 no hydrogen 3.504 N/A ARG 50.A NH2 GLU 8.A OE2 no hydrogen 3.122 N/A HIS 51.A N LEU 47.A O no hydrogen 2.952 N/A HIS 51.A ND1 LEU 47.A O no hydrogen 2.898 N/A GLY 52.A N ARG 49.A O no hydrogen 3.153 N/A VAL 53.A N ALA 48.A O no hydrogen 2.787 N/A HIS 56.A N HIS 65.A O no hydrogen 2.877 N/A PHE 58.A N THR 63.A O no hydrogen 2.824 N/A GLU 60.A N GLU 60.A OE2 no hydrogen 2.751 N/A THR 63.A N PHE 58.A O no hydrogen 2.941 N/A ALA 64.A N PHE 75.A O no hydrogen 2.881 N/A HIS 65.A N HIS 56.A O no hydrogen 2.936 N/A LEU 66.A N LEU 73.A O no hydrogen 2.940 N/A ILE 68.A N LEU 71.A O no hydrogen 2.907 N/A LEU 71.A N ILE 68.A O no hydrogen 2.903 N/A LYS 72.A N TRP 30.A O no hydrogen 2.685 N/A LEU 73.A N LEU 66.A O no hydrogen 2.864 N/A GLU 74.A N VAL 32.A O no hydrogen 2.980 N/A PHE 75.A N ALA 64.A O no hydrogen 2.899 N/A ALA 76.A N PHE 34.A O no hydrogen 2.901 N/A THR 77.A N GLY 62.A O no hydrogen 3.298 N/A THR 77.A OG1 GLY 62.A O no hydrogen 3.083 N/A ALA 78.A N VAL 36.A O no hydrogen 3.004 N/A ARG 79.A N ASP 90.A OD2 no hydrogen 3.119 N/A ARG 79.A NH1 GLU 81.A O no hydrogen 3.518 N/A ARG 80.A NE GLU 89.A OE2 no hydrogen 3.420 N/A ARG 80.A NH1 GLU 83.A O no hydrogen 3.058 N/A ARG 80.A NH2 PRO 84.A O no hydrogen 3.085 N/A ARG 80.A NH2 GLU 89.A OE2 no hydrogen 3.326 N/A SER 86.A N GLU 89.A OE1 no hydrogen 3.268 N/A LEU 87.A N GLU 37.A OE2 no hydrogen 3.314 N/A GLU 89.A N SER 86.A OG no hydrogen 3.317 N/A ASP 90.A N SER 86.A O no hydrogen 3.186 N/A LEU 91.A N LEU 87.A O no hydrogen 2.906 N/A ILE 92.A N LYS 88.A O no hydrogen 2.918 N/A ARG 93.A NE ARG 79.A O no hydrogen 3.318 N/A ARG 93.A NE ASP 90.A OD2 no hydrogen 3.470 N/A ARG 93.A NH2 ASP 90.A OD2 no hydrogen 3.365 N/A ARG 94.A N LEU 91.A O no hydrogen 3.143 N/A ARG 94.A NH2 ASP 90.A OD1 no hydrogen 2.909 N/A PHE 96.A N ASP 95.A OD1 no hydrogen 2.510 N/A THR 97.A N ARG 129.A O no hydrogen 3.046 N/A THR 97.A OG1 ASP 122.A OD2 no hydrogen 2.645 N/A ASN 99.A N PHE 96.A O no hydrogen 2.763 N/A ASN 99.A ND2 ASP 95.A OD1 no hydrogen 3.148 N/A ASN 99.A ND2 ASP 95.A OD2 no hydrogen 3.285 N/A ALA 100.A N THR 97.A O no hydrogen 2.969 N/A ALA 102.A N ILE 114.A O no hydrogen 3.026 N/A ILE 103.A N ILE 15.A O no hydrogen 2.886 N/A SER 104.A N THR 112.A O no hydrogen 2.950 N/A SER 104.A OG ASP 109.A OD1 no hydrogen 2.736 N/A SER 104.A OG ASP 109.A OD2 no hydrogen 2.827 N/A VAL 105.A N ALA 13.A O no hydrogen 3.399 N/A ASN 106.A N SER 104.A OG no hydrogen 3.161 N/A GLU 108.A N GLU 108.A OE1 no hydrogen 2.597 N/A GLY 111.A N SER 104.A O no hydrogen 2.957 N/A THR 112.A N ASP 109.A O no hydrogen 3.048 N/A THR 112.A OG1 ASP 109.A O no hydrogen 2.484 N/A ILE 114.A N ALA 102.A O no hydrogen 2.507 N/A GLY 119.A N ASP 115.A OD1 no hydrogen 2.911 N/A LEU 120.A N ASP 115.A OD2 no hydrogen 2.857 N/A ASP 122.A N GLY 118.A O no hydrogen 3.231 N/A LEU 123.A N GLY 119.A O no hydrogen 2.885 N/A LYS 124.A N LEU 120.A O no hydrogen 2.917 N/A LYS 124.A NZ ASP 125.A OD1 no hydrogen 2.858 N/A ASP 125.A N ARG 121.A O no hydrogen 2.799 N/A VAL 127.A N ASP 122.A O no hydrogen 2.702 N/A ILE 128.A N LYS 156.A O no hydrogen 2.754 N/A ARG 129.A NE ASP 122.A OD1 no hydrogen 3.481 N/A ARG 129.A NE ASP 122.A OD2 no hydrogen 3.275 N/A VAL 130.A N THR 161.A OG1 no hydrogen 3.222 N/A HIS 132.A NE2 GLU 138.A OE1 no hydrogen 2.773 N/A SER 135.A N HIS 132.A O no hydrogen 3.036 N/A GLU 138.A N VAL 134.A O no hydrogen 2.764 N/A ASP 139.A N SER 135.A O no hydrogen 3.188 N/A ARG 142.A N ASP 139.A O no hydrogen 2.858 N/A ARG 142.A NH1 SER 135.A OG no hydrogen 2.817 N/A ILE 143.A N PRO 140.A O no hydrogen 2.938 N/A LEU 144.A N VAL 141.A O no hydrogen 2.922 N/A ARG 145.A N VAL 141.A O no hydrogen 3.187 N/A ARG 145.A NE ASP 95.A OD2 no hydrogen 3.189 N/A ARG 145.A NH2 ASP 95.A OD2 no hydrogen 2.978 N/A ALA 146.A N ARG 142.A O no hydrogen 2.757 N/A ARG 148.A N LEU 144.A O no hydrogen 2.915 N/A PHE 149.A N ARG 145.A O no hydrogen 2.894 N/A ALA 150.A N ALA 146.A O no hydrogen 2.791 N/A GLY 151.A N LEU 147.A O no hydrogen 2.583 N/A ARG 152.A N ARG 148.A O no hydrogen 2.654 N/A ARG 152.A NE GLU 192.A OE1 no hydrogen 3.352 N/A ARG 152.A NE GLU 192.A OE2 no hydrogen 2.797 N/A ARG 152.A NH2 GLU 192.A OE2 no hydrogen 2.802 N/A LEU 153.A N PHE 149.A O no hydrogen 2.719 N/A PHE 155.A N ALA 150.A O no hydrogen 3.219 N/A LYS 156.A N LYS 126.A O no hydrogen 2.978 N/A SER 158.A N ILE 128.A O no hydrogen 3.030 N/A THR 161.A OG1 ILE 128.A O no hydrogen 3.456 N/A GLU 162.A N SER 158.A O no hydrogen 2.730 N/A LYS 163.A N ARG 159.A O no hydrogen 2.934 N/A LEU 164.A N SER 160.A O no hydrogen 2.890 N/A LEU 165.A N THR 161.A O no hydrogen 2.903 N/A LYS 166.A N GLU 162.A O no hydrogen 2.950 N/A GLN 167.A N LYS 163.A O no hydrogen 2.912 N/A ALA 168.A N LEU 164.A O no hydrogen 2.893 N/A VAL 169.A N LEU 165.A O no hydrogen 2.932 N/A ASN 170.A N LYS 166.A O no hydrogen 2.912 N/A LEU 171.A N GLN 167.A O no hydrogen 3.001 N/A GLY 172.A N VAL 169.A O no hydrogen 2.936 N/A LEU 173.A N ALA 168.A O no hydrogen 3.469 N/A LYS 175.A N GLY 172.A O no hydrogen 2.923 N/A LYS 175.A NZ GLU 210.A O no hydrogen 3.264 N/A GLU 176.A N LEU 173.A O no hydrogen 3.084 N/A ALA 177.A N LEU 173.A O no hydrogen 2.985 N/A ARG 179.A NE GLU 269.A OE1 no hydrogen 2.780 N/A ARG 179.A NH1 ILE 211.A O no hydrogen 2.647 N/A ARG 179.A NH2 ILE 211.A O no hydrogen 2.921 N/A ARG 179.A NH2 GLU 269.A OE1 no hydrogen 3.116 N/A ARG 181.A NH2 ASP 139.A OD2 no hydrogen 2.389 N/A LEU 182.A N PRO 178.A O no hydrogen 3.410 N/A ILE 183.A N ARG 179.A O no hydrogen 2.929 N/A ASN 184.A N GLY 180.A O no hydrogen 2.894 N/A GLU 185.A N ARG 181.A O no hydrogen 2.910 N/A ILE 186.A N LEU 182.A O no hydrogen 2.929 N/A LYS 187.A N ILE 183.A O no hydrogen 2.885 N/A LYS 187.A NZ SER 271.A OG no hydrogen 2.680 N/A LEU 188.A N ASN 184.A O no hydrogen 2.913 N/A ALA 189.A N GLU 185.A O no hydrogen 2.904 N/A LEU 190.A N ILE 186.A O no hydrogen 2.942 N/A ARG 191.A N LEU 188.A O no hydrogen 3.323 N/A GLU 192.A N ALA 189.A O no hydrogen 2.982 N/A GLU 197.A N ARG 194.A O no hydrogen 2.721 N/A GLU 197.A N GLU 197.A OE1 no hydrogen 2.602 N/A ILE 198.A N ARG 194.A O no hydrogen 3.262 N/A LEU 199.A N PHE 195.A O no hydrogen 2.871 N/A GLU 200.A N LEU 196.A O no hydrogen 2.923 N/A LEU 201.A N GLU 197.A O no hydrogen 2.960 N/A TYR 202.A N ILE 198.A O no hydrogen 2.850 N/A ARG 203.A N LEU 199.A O no hydrogen 2.914 N/A ARG 203.A NE GLU 200.A OE1 no hydrogen 3.291 N/A ARG 203.A NH2 GLU 200.A OE1 no hydrogen 2.963 N/A LYS 204.A N GLU 200.A O no hydrogen 2.910 N/A LYS 204.A NZ TYR 205.A OH no hydrogen 3.268 N/A TYR 205.A N LEU 201.A O no hydrogen 2.927 N/A ARG 206.A N ARG 203.A O no hydrogen 3.356 N/A VAL 207.A N TYR 202.A O no hydrogen 3.180 N/A GLU 209.A N GLU 209.A OE1 no hydrogen 2.575 N/A GLU 210.A N VAL 207.A O no hydrogen 3.218 N/A ILE 211.A N VAL 207.A O no hydrogen 3.244 N/A ILE 212.A N LEU 208.A O no hydrogen 2.905 N/A PHE 215.A N ILE 212.A O no hydrogen 3.355 N/A VAL 221.A N ASN 218.A OD1 no hydrogen 3.037 N/A GLN 223.A N GLU 219.A O no hydrogen 2.915 N/A GLN 223.A NE2 GLU 219.A OE2 no hydrogen 3.468 N/A LYS 224.A N LYS 220.A O no hydrogen 2.917 N/A LEU 225.A N VAL 221.A O no hydrogen 2.879 N/A TYR 226.A N LEU 222.A O no hydrogen 2.968 N/A TYR 226.A OH GLU 200.A OE2 no hydrogen 2.994 N/A ALA 227.A N GLN 223.A O no hydrogen 2.904 N/A LEU 228.A N LYS 224.A O no hydrogen 2.910 N/A ARG 229.A N LEU 225.A O no hydrogen 2.905 N/A ARG 229.A NH1 GLU 197.A OE1 no hydrogen 3.240 N/A ARG 229.A NH2 GLU 197.A OE2 no hydrogen 2.440 N/A LYS 230.A N TYR 226.A O no hydrogen 2.963 N/A VAL 231.A N ALA 227.A O no hydrogen 2.953 N/A VAL 232.A N LEU 228.A O no hydrogen 2.876 N/A ASP 233.A N ARG 229.A O no hydrogen 2.900 N/A TRP 234.A N LYS 230.A O no hydrogen 2.964 N/A HIS 235.A N VAL 231.A O no hydrogen 2.895 N/A HIS 235.A ND1 TYR 246.A OH no hydrogen 2.950 N/A ALA 236.A N VAL 232.A O no hydrogen 2.891 N/A LEU 237.A N TRP 234.A O no hydrogen 2.999 N/A GLU 238.A N TRP 234.A O no hydrogen 2.948 N/A PHE 239.A N HIS 235.A O no hydrogen 2.956 N/A GLU 241.A N GLU 241.A OE1 no hydrogen 2.689 N/A GLU 242.A N PHE 239.A O no hydrogen 2.494 N/A ARG 243.A N SER 240.A O no hydrogen 3.444 N/A ARG 243.A NE ALA 236.A O no hydrogen 3.160 N/A ARG 243.A NH2 ALA 236.A O no hydrogen 2.582 N/A TYR 246.A OH HIS 235.A ND1 no hydrogen 2.950 N/A LEU 249.A N TYR 246.A O no hydrogen 2.923 N/A LEU 251.A N GLY 247.A O no hydrogen 2.944 N/A LEU 252.A N TRP 248.A O no hydrogen 2.895 N/A ILE 253.A N LEU 249.A O no hydrogen 2.915 N/A LEU 254.A N TYR 250.A O no hydrogen 2.934 N/A ILE 255.A N LEU 251.A O no hydrogen 3.152 N/A SER 256.A N ILE 253.A O no hydrogen 3.336 N/A SER 256.A OG ILE 253.A O no hydrogen 2.466 N/A SER 256.A OG ASN 257.A OD1 no hydrogen 3.291 N/A LEU 258.A N ILE 255.A O no hydrogen 2.981 N/A GLY 263.A N ASP 259.A O no hydrogen 2.863 N/A LYS 264.A N TYR 260.A O no hydrogen 2.903 N/A LYS 264.A NZ GLU 268.A OE2 no hydrogen 3.337 N/A HIS 265.A N GLU 261.A O no hydrogen 2.925 N/A PHE 266.A N ARG 262.A O no hydrogen 2.896 N/A LEU 267.A N GLY 263.A O no hydrogen 2.919 N/A GLU 268.A N LYS 264.A O no hydrogen 2.902 N/A GLU 269.A N HIS 265.A O no hydrogen 2.917 N/A MET 270.A N PHE 266.A O no hydrogen 2.809 N/A SER 271.A N GLU 268.A O no hydrogen 3.104 N/A SER 271.A OG MET 270.A O no hydrogen 2.472 N/A ALA 272.A N LEU 267.A O no hydrogen 3.274 N/A VAL 276.A N PRO 273.A O no hydrogen 3.138 N/A ARG 277.A N PRO 273.A O no hydrogen 3.322 N/A GLU 278.A N SER 274.A O no hydrogen 2.914 N/A THR 279.A N TRP 275.A O no hydrogen 2.905 N/A THR 279.A OG1 TRP 275.A O no hydrogen 2.590 N/A THR 279.A OG1 SER 313.A OG no hydrogen 2.477 N/A TYR 280.A N VAL 276.A O no hydrogen 2.905 N/A LYS 281.A N ARG 277.A O no hydrogen 2.910 N/A LYS 281.A NZ TYR 260.A OH no hydrogen 3.043 N/A PHE 282.A N GLU 278.A O no hydrogen 2.909 N/A MET 283.A N THR 279.A O no hydrogen 2.881 N/A LYS 284.A N TYR 280.A O no hydrogen 2.902 N/A LYS 284.A NZ SER 256.A O no hydrogen 3.004 N/A LEU 287.A N PHE 282.A O no hydrogen 2.800 N/A SER 289.A OG LYS 286.A O no hydrogen 2.964 N/A LEU 290.A N LYS 286.A O no hydrogen 2.915 N/A LYS 291.A N LEU 287.A O no hydrogen 2.894 N/A LYS 291.A NZ GLU 321.A OE2 no hydrogen 2.665 N/A GLU 292.A N GLY 288.A O no hydrogen 2.922 N/A GLU 293.A N SER 289.A O no hydrogen 2.905 N/A LEU 294.A N LEU 290.A O no hydrogen 2.888 N/A LYS 295.A N LYS 291.A O no hydrogen 2.916 N/A LYS 295.A NZ GLU 292.A OE2 no hydrogen 3.177 N/A LYS 296.A N GLU 293.A O no hydrogen 3.129 N/A LYS 296.A NZ GLU 292.A O no hydrogen 3.066 N/A ALA 297.A N LEU 294.A O no hydrogen 3.274 N/A ASN 300.A N ASN 367.A OD1 no hydrogen 3.188 N/A TYR 301.A OH GLU 359.A OE1 no hydrogen 2.345 N/A TYR 304.A N ASN 300.A O no hydrogen 2.916 N/A ARG 305.A N TYR 301.A O no hydrogen 2.895 N/A LEU 306.A N GLU 302.A O no hydrogen 2.921 N/A LEU 307.A N VAL 303.A O no hydrogen 2.907 N/A LEU 307.A N TYR 304.A O no hydrogen 3.051 N/A LYS 308.A N TYR 304.A O no hydrogen 2.905 N/A LEU 310.A N LEU 307.A O no hydrogen 2.631 N/A SER 313.A OG THR 279.A OG1 no hydrogen 2.477 N/A LEU 316.A N THR 312.A O no hydrogen 2.919 N/A LEU 317.A N SER 313.A O no hydrogen 2.914 N/A LEU 318.A N VAL 314.A O no hydrogen 2.894 N/A MET 319.A N LEU 315.A O no hydrogen 2.923 N/A LEU 320.A N LEU 317.A O no hydrogen 3.362 N/A GLU 321.A N LEU 318.A O no hydrogen 3.198 N/A LYS 325.A N GLU 322.A O no hydrogen 3.346 N/A LYS 325.A NZ GLU 322.A OE2 no hydrogen 3.563 N/A ILE 328.A N LEU 324.A O no hydrogen 2.900 N/A LYS 329.A N LYS 325.A O no hydrogen 2.913 N/A LEU 330.A N GLU 326.A O no hydrogen 2.902 N/A TYR 331.A N LYS 327.A O no hydrogen 2.922 N/A LEU 332.A N ILE 328.A O no hydrogen 2.899 N/A GLU 333.A N LYS 329.A O no hydrogen 2.944 N/A LYS 334.A NZ GLU 333.A O no hydrogen 3.252 N/A LEU 335.A N LEU 330.A O no hydrogen 3.001 N/A ARG 336.A N TYR 331.A O no hydrogen 3.342 N/A ARG 336.A NH2 GLU 242.A OE2 no hydrogen 2.929 N/A LYS 337.A N LYS 334.A O no hydrogen 3.151 N/A GLU 346.A N LYS 342.A O no hydrogen 2.901 N/A GLU 347.A N GLU 343.A O no hydrogen 2.918 N/A LEU 348.A N LYS 344.A O no hydrogen 2.894 N/A LYS 349.A N ILE 345.A O no hydrogen 2.912 N/A LYS 350.A N GLU 347.A O no hydrogen 3.301 N/A GLU 356.A N LYS 352.A O no hydrogen 2.923 N/A ARG 357.A N GLU 353.A O no hydrogen 2.898 N/A ILE 358.A N LEU 354.A O no hydrogen 2.906 N/A GLU 359.A N GLY 355.A O no hydrogen 2.915 N/A GLU 360.A N GLU 356.A O no hydrogen 2.921 N/A LEU 361.A N ARG 357.A O no hydrogen 2.899 N/A LYS 362.A N ILE 358.A O no hydrogen 2.897 N/A LYS 362.A NZ TYR 304.A OH no hydrogen 2.481 N/A LYS 362.A NZ GLU 359.A OE1 no hydrogen 3.382 N/A LYS 362.A NZ GLU 359.A OE2 no hydrogen 3.059 N/A ARG 363.A N GLU 359.A O no hydrogen 2.920 N/A GLU 364.A N GLU 360.A O no hydrogen 2.927 N/A ILE 365.A N LEU 361.A O no hydrogen 2.898 N/A MET 366.A N LYS 362.A O no hydrogen 2.910 N/A