Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4x2l_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLY 1.A N ILE 172.A O no hydrogen 2.824 N/A PHE 3.A N ASP 173.A OD2 no hydrogen 2.974 N/A GLU 5.A N GLU 5.A OE1 no hydrogen 2.752 N/A MET 6.A N PHE 3.A O no hydrogen 3.182 N/A VAL 7.A N VAL 4.A O no hydrogen 3.426 N/A ASP 8.A N SER 166.A OG no hydrogen 2.756 N/A ASN 9.A ND2 HIS 93.A O no hydrogen 2.851 N/A ASN 9.A ND2 MET 167.A O no hydrogen 3.038 N/A LEU 10.A N GLY 165.A O no hydrogen 3.126 N/A ARG 11.A N TYR 19.A O no hydrogen 3.039 N/A ARG 11.A NH1 ASP 8.A OD2 no hydrogen 2.803 N/A ARG 11.A NH2 ASP 8.A O no hydrogen 3.066 N/A ARG 11.A NH2 ASP 8.A OD1 no hydrogen 3.419 N/A ARG 11.A NH2 ASP 8.A OD2 no hydrogen 3.309 N/A ARG 11.A NH2 LEU 10.A O no hydrogen 2.844 N/A GLN 16.A N LYS 13.A O no hydrogen 2.833 N/A TYR 18.A OH GLU 325.A OE1 no hydrogen 2.721 N/A TYR 19.A N ARG 11.A O no hydrogen 2.868 N/A VAL 20.A N ILE 33.A O no hydrogen 2.817 N/A MET 22.A N LEU 31.A O no hydrogen 2.802 N/A THR 23.A N SER 90.A O no hydrogen 2.852 N/A THR 23.A OG1 SER 90.A OG no hydrogen 2.753 N/A VAL 24.A N.A GLN 29.A O no hydrogen 2.915 N/A VAL 24.A N.B GLN 29.A O no hydrogen 2.921 N/A GLY 25.A N LEU 88.A O no hydrogen 2.861 N/A SER 26.A N SER 61.A OG no hydrogen 2.966 N/A SER 26.A OG THR 63.A OG1 no hydrogen 2.862 N/A GLN 29.A N VAL 24.A O.A no hydrogen 2.828 N/A GLN 29.A N VAL 24.A O.B no hydrogen 2.906 N/A GLN 29.A NE2 GLN 57.A O no hydrogen 2.956 N/A LEU 31.A N MET 22.A O no hydrogen 2.862 N/A ASN 32.A N GLU 120.A OE2 no hydrogen 2.814 N/A ASN 32.A ND2 ASN 118.A O no hydrogen 2.900 N/A ILE 33.A N VAL 20.A O no hydrogen 2.854 N/A LEU 34.A N GLY 121.A O no hydrogen 2.926 N/A VAL 35.A N TYR 18.A O no hydrogen 2.736 N/A ASP 36.A N LEU 123.A O no hydrogen 3.030 N/A THR 37.A N SER 222.A OG no hydrogen 3.022 N/A THR 37.A OG1 VAL 220.A O no hydrogen 2.937 N/A GLY 38.A N ASP 36.A OD1 no hydrogen 3.039 N/A SER 39.A OG ASP 36.A OD2 no hydrogen 2.578 N/A SER 40.A OG TYR 127.A O no hydrogen 2.632 N/A ASN 41.A ND2 ARG 132.A O no hydrogen 3.105 N/A ALA 43.A N ILE 122.A O no hydrogen 3.145 N/A VAL 44.A N ALA 104.A O no hydrogen 2.927 N/A GLY 45.A N GLU 120.A O no hydrogen 2.771 N/A ALA 46.A N ILE 106.A O no hydrogen 3.071 N/A HIS 49.A N ALA 47.A O no hydrogen 2.727 N/A PHE 51.A N HIS 49.A ND1 no hydrogen 3.082 N/A LEU 52.A N HIS 49.A O no hydrogen 3.193 N/A ARG 54.A NE THR 30.A O no hydrogen 3.337 N/A TYR 56.A N GLY 45.A O no hydrogen 2.778 N/A TYR 56.A OH ASP 87.A OD2 no hydrogen 2.615 N/A GLN 57.A N GLN 29.A OE1 no hydrogen 2.809 N/A ARG 58.A NH1 GLU 83.A OE1 no hydrogen 2.725 N/A ARG 58.A NH2 GLU 83.A OE1 no hydrogen 3.004 N/A GLN 59.A N GLN 59.A OE1 no hydrogen 2.919 N/A GLN 59.A NE2 GLN 57.A OE1 no hydrogen 3.504 N/A LEU 60.A N GLN 57.A O no hydrogen 3.131 N/A SER 61.A N ARG 58.A O no hydrogen 2.809 N/A SER 61.A OG ASP 87.A OD1 no hydrogen 3.326 N/A SER 61.A OG ASP 87.A OD2 no hydrogen 2.935 N/A SER 62.A N SER 26.A O no hydrogen 3.092 N/A SER 62.A OG SER 26.A O no hydrogen 3.308 N/A THR 63.A OG1 SER 26.A OG no hydrogen 2.862 N/A THR 63.A OG1 SER 61.A OG no hydrogen 3.352 N/A THR 63.A OG1 ASP 87.A OD1 no hydrogen 2.773 N/A ARG 65.A N THR 86.A O no hydrogen 2.840 N/A LEU 67.A N LEU 84.A O no hydrogen 3.199 N/A ARG 68.A N ASP 66.A OD1 no hydrogen 3.007 N/A ARG 68.A NH2 ASP 66.A OD2 no hydrogen 3.452 N/A VAL 71.A N GLY 82.A O no hydrogen 3.001 N/A VAL 73.A N TRP 80.A O no hydrogen 2.672 N/A TYR 75.A N GLY 78.A O no hydrogen 3.245 N/A LYS 79.A NZ GLU 81.A OE1 no hydrogen 3.338 N/A TRP 80.A N VAL 73.A O no hydrogen 3.060 N/A TRP 80.A NE1 TYR 75.A OH no hydrogen 2.804 N/A GLU 81.A N GLU 108.A O no hydrogen 2.793 N/A GLY 82.A N VAL 71.A O no hydrogen 2.937 N/A GLU 83.A N ALA 105.A O no hydrogen 2.862 N/A LEU 84.A N LYS 69.A O no hydrogen 2.874 N/A GLY 85.A N ILE 103.A O no hydrogen 3.100 N/A THR 86.A N ARG 65.A O no hydrogen 2.866 N/A ASP 87.A N ALA 101.A O no hydrogen 3.282 N/A LEU 88.A N ASP 87.A OD1 no hydrogen 2.755 N/A VAL 89.A N VAL 99.A O no hydrogen 2.786 N/A SER 90.A N THR 23.A O no hydrogen 2.986 N/A SER 90.A OG THR 23.A OG1 no hydrogen 2.753 N/A VAL 97.A N PRO 95.A O no hydrogen 2.939 N/A VAL 99.A N VAL 89.A O no hydrogen 2.979 N/A ARG 100.A N GLN 147.A OE1 no hydrogen 2.921 N/A ARG 100.A NH1 THR 63.A O no hydrogen 2.982 N/A ARG 100.A NH1 THR 86.A OG1 no hydrogen 2.903 N/A ARG 100.A NH2 THR 63.A O no hydrogen 2.776 N/A ALA 101.A N ASP 87.A O no hydrogen 3.131 N/A ASN 102.A ND2 GLU 138.A O no hydrogen 2.949 N/A ILE 103.A N GLY 85.A O no hydrogen 2.784 N/A ALA 104.A N PHE 42.A O no hydrogen 2.894 N/A ALA 105.A N GLU 83.A O no hydrogen 2.876 N/A ILE 106.A N VAL 44.A O no hydrogen 2.861 N/A THR 107.A N GLU 81.A O no hydrogen 2.991 N/A THR 107.A OG1 GLU 81.A O no hydrogen 3.502 N/A GLU 108.A N GLU 81.A O no hydrogen 3.220 N/A ASP 110.A N LYS 79.A O no hydrogen 2.798 N/A SER 117.A N ILE 114.A O no hydrogen 3.121 N/A SER 117.A OG ILE 114.A O no hydrogen 2.711 N/A TRP 119.A NE1 GLN 16.A O no hydrogen 3.005 N/A GLU 120.A N ASN 32.A O no hydrogen 2.883 N/A ILE 122.A N ALA 43.A O no hydrogen 2.787 N/A LEU 123.A N LEU 34.A O no hydrogen 2.739 N/A GLY 124.A N ASN 41.A O no hydrogen 2.830 N/A LEU 125.A N ASP 36.A O no hydrogen 2.864 N/A ALA 126.A N SER 39.A O no hydrogen 2.949 N/A TYR 127.A N TRP 190.A O no hydrogen 2.889 N/A ILE 130.A N TYR 127.A O no hydrogen 3.156 N/A ALA 131.A N ALA 128.A O no hydrogen 2.834 N/A ARG 132.A N ASN 41.A OD1 no hydrogen 2.835 N/A SER 136.A N ASP 134.A OD1 no hydrogen 3.067 N/A SER 136.A OG ASP 134.A OD1 no hydrogen 2.642 N/A LEU 137.A N ASP 134.A O no hydrogen 3.208 N/A SER 143.A N PRO 139.A O no hydrogen 3.217 N/A SER 143.A OG GLU 138.A OE2 no hydrogen 2.660 N/A SER 143.A OG PRO 139.A O no hydrogen 3.438 N/A LEU 144.A N PHE 140.A O no hydrogen 2.843 N/A VAL 145.A N PHE 141.A O no hydrogen 2.988 N/A LYS 146.A N ASP 142.A O no hydrogen 3.047 N/A LYS 146.A NZ GLU 138.A OE1 no hydrogen 2.929 N/A GLN 147.A N SER 143.A O no hydrogen 3.070 N/A GLN 147.A NE2 ARG 100.A O no hydrogen 2.857 N/A THR 148.A OG1 LEU 144.A O no hydrogen 2.677 N/A VAL 150.A N THR 148.A OG1 no hydrogen 3.195 N/A LEU 153.A N PRO 151.A O no hydrogen 2.745 N/A PHE 154.A N PHE 331.A O no hydrogen 3.395 N/A SER 155.A N ILE 168.A O no hydrogen 2.908 N/A SER 155.A OG GLY 171.A O no hydrogen 2.871 N/A SER 155.A OG TYR 328.A OH no hydrogen 2.641 N/A LEU 156.A N VAL 329.A O no hydrogen 2.866 N/A GLN 157.A N SER 166.A O no hydrogen 2.845 N/A GLN 157.A NE2 LEU 176.A O no hydrogen 2.965 N/A CYS 159.A N GLY 164.A O no hydrogen 2.972 N/A CYS 159.A SG GLN 157.A OE1 no hydrogen 3.320 N/A VAL 163.A N GLY 12.A O no hydrogen 2.982 N/A GLY 165.A N LEU 10.A O no hydrogen 3.249 N/A SER 166.A N GLN 157.A O no hydrogen 2.816 N/A MET 167.A N ASN 9.A OD1 no hydrogen 2.801 N/A ILE 168.A N SER 155.A O no hydrogen 2.987 N/A GLY 170.A N LEU 153.A O no hydrogen 2.798 N/A ASP 173.A N TYR 328.A OH no hydrogen 2.994 N/A HIS 174.A N GLY 1.A O no hydrogen 3.422 N/A HIS 174.A ND1 TYR 177.A OH no hydrogen 2.773 N/A SER 175.A N ASP 173.A OD1 no hydrogen 3.257 N/A SER 175.A OG ASP 173.A OD1 no hydrogen 2.607 N/A LEU 176.A N ASP 173.A O no hydrogen 3.079 N/A TYR 177.A OH HIS 174.A ND1 no hydrogen 2.773 N/A THR 178.A N VAL 342.A O no hydrogen 2.893 N/A SER 180.A OG LEU 181.A O no hydrogen 3.479 N/A TRP 182.A N PHE 340.A O no hydrogen 2.803 N/A THR 184.A N ILE 338.A O no hydrogen 2.815 N/A THR 184.A OG1 MET 281.A O no hydrogen 2.643 N/A ILE 186.A N LYS 336.A O no hydrogen 3.015 N/A ARG 187.A N GLU 193.A O no hydrogen 2.836 N/A ARG 187.A NH1 GLU 193.A OE2 no hydrogen 3.249 N/A ARG 187.A NH1 TYR 370.A O no hydrogen 2.916 N/A ARG 187.A NH2 TYR 370.A O no hydrogen 3.054 N/A TRP 190.A N ARG 188.A O no hydrogen 3.156 N/A TRP 190.A N TYR 191.A O no hydrogen 3.371 N/A TRP 190.A NE1 GLU 193.A OE1 no hydrogen 3.067 N/A TYR 192.A OH LEU 125.A O no hydrogen 2.671 N/A GLU 193.A N TYR 191.A O no hydrogen 2.916 N/A VAL 194.A N SER 218.A O no hydrogen 2.882 N/A ILE 196.A N ASN 214.A OD1 no hydrogen 2.854 N/A VAL 197.A N TYR 279.A O no hydrogen 2.781 N/A ARG 198.A NE GLU 200.A OE2 no hydrogen 3.030 N/A ARG 198.A NH1 GLU 200.A OE2 no hydrogen 2.818 N/A GLU 200.A N SER 277.A O no hydrogen 3.019 N/A ILE 201.A N GLN 204.A O no hydrogen 2.893 N/A ASN 202.A N VAL 275.A O no hydrogen 2.934 N/A GLN 204.A N ILE 201.A O no hydrogen 3.149 N/A LEU 206.A N VAL 199.A O no hydrogen 3.094 N/A LYS 207.A N ASP 205.A OD1 no hydrogen 2.986 N/A LYS 207.A NZ ASP 205.A O no hydrogen 3.142 N/A LYS 211.A N ASP 209.A OD1 no hydrogen 3.225 N/A LYS 211.A NZ GLY 369.A O no hydrogen 3.113 N/A GLU 212.A N ASP 209.A O no hydrogen 2.997 N/A TYR 213.A N CYS 210.A O no hydrogen 3.124 N/A ASN 214.A N LYS 211.A O no hydrogen 3.364 N/A ASN 214.A ND2 ILE 196.A O no hydrogen 2.803 N/A ASN 214.A ND2 CYS 210.A O no hydrogen 3.075 N/A ASN 214.A ND2 CYS 368.A O no hydrogen 2.913 N/A LYS 217.A NZ THR 315.A O no hydrogen 2.763 N/A SER 218.A OG ASN 214.A OD1 no hydrogen 2.722 N/A ILE 219.A N THR 317.A O no hydrogen 2.953 N/A VAL 220.A N TYR 192.A O no hydrogen 3.059 N/A ASP 221.A N MET 319.A O no hydrogen 2.953 N/A SER 222.A N THR 37.A OG1 no hydrogen 3.051 N/A SER 222.A OG VAL 35.A O no hydrogen 2.826 N/A GLY 223.A N ASP 221.A OD1 no hydrogen 2.837 N/A THR 224.A N ASP 221.A O no hydrogen 3.442 N/A THR 224.A OG1 ASP 221.A OD2 no hydrogen 2.666 N/A ASN 226.A ND2 SER 311.A OG no hydrogen 2.799 N/A LEU 227.A N ALA 309.A O no hydrogen 3.120 N/A ARG 228.A N VAL 318.A O no hydrogen 2.964 N/A LEU 229.A N SER 311.A O no hydrogen 2.788 N/A LYS 231.A NZ GLN 312.A OE1 no hydrogen 3.120 N/A LYS 232.A NZ GLU 212.A OE2 no hydrogen 2.900 N/A PHE 234.A N PRO 230.A O no hydrogen 2.793 N/A GLU 235.A N LYS 231.A O no hydrogen 2.809 N/A ALA 236.A N LYS 232.A O no hydrogen 3.139 N/A ALA 237.A N VAL 233.A O no hydrogen 2.806 N/A VAL 238.A N PHE 234.A O no hydrogen 2.805 N/A LYS 239.A N GLU 235.A O no hydrogen 2.976 N/A SER 240.A N ALA 236.A O no hydrogen 3.077 N/A ILE 241.A N ALA 237.A O no hydrogen 2.767 N/A LYS 242.A N VAL 238.A O no hydrogen 2.693 N/A ALA 243.A N LYS 239.A O no hydrogen 3.191 N/A ALA 244.A N SER 240.A O no hydrogen 3.097 N/A SER 245.A N ILE 241.A O no hydrogen 2.830 N/A SER 245.A OG ILE 241.A O no hydrogen 2.693 N/A SER 245.A OG LYS 242.A O no hydrogen 3.565 N/A SER 246.A N ALA 243.A O no hydrogen 3.354 N/A SER 246.A OG ALA 243.A O no hydrogen 2.946 N/A PHE 254.A N PRO 251.A O no hydrogen 3.214 N/A LEU 256.A N GLY 253.A O no hydrogen 3.243 N/A GLY 257.A N PHE 254.A O no hydrogen 2.944 N/A GLU 258.A N GLY 253.A O no hydrogen 2.996 N/A VAL 261.A N TYR 306.A O no hydrogen 3.236 N/A TRP 263.A N ASP 304.A O no hydrogen 3.128 N/A THR 267.A N GLN 264.A O no hydrogen 3.219 N/A THR 268.A OG1 TYR 306.A OH no hydrogen 3.296 N/A PHE 273.A N TRP 270.A O no hydrogen 2.937 N/A VAL 275.A N ASN 202.A OD1 no hydrogen 3.030 N/A ILE 276.A N ILE 293.A O no hydrogen 2.968 N/A SER 277.A N GLU 200.A O no hydrogen 2.844 N/A SER 277.A OG THR 292.A OG1 no hydrogen 2.674 N/A LEU 278.A N ILE 291.A O no hydrogen 2.923 N/A TYR 279.A N ARG 198.A O no hydrogen 2.852 N/A TYR 279.A OH GLU 200.A OE1 no hydrogen 3.284 N/A TYR 279.A OH GLU 200.A OE2 no hydrogen 2.798 N/A LEU 280.A N PHE 289.A O no hydrogen 2.880 N/A MET 281.A N ILE 195.A O no hydrogen 3.106 N/A GLY 282.A N GLN 287.A O no hydrogen 2.885 N/A ASN 286.A ND2 THR 362.A O no hydrogen 3.424 N/A GLN 287.A N VAL 284.A O no hydrogen 3.042 N/A SER 288.A N PHE 360.A O no hydrogen 2.812 N/A SER 288.A OG THR 362.A OG1 no hydrogen 2.846 N/A PHE 289.A N LEU 280.A O no hydrogen 3.214 N/A ARG 290.A N GLU 357.A O no hydrogen 2.729 N/A ARG 290.A NH1 TYR 279.A OH no hydrogen 2.771 N/A ARG 290.A NH2 GLU 357.A OE2 no hydrogen 3.046 N/A ILE 291.A N LEU 278.A O no hydrogen 2.911 N/A THR 292.A N ALA 355.A O no hydrogen 2.802 N/A THR 292.A OG1 SER 277.A OG no hydrogen 2.674 N/A ILE 293.A N ILE 276.A O no hydrogen 2.813 N/A LEU 294.A N GLN 297.A OE1 no hydrogen 3.033 N/A GLN 296.A N GLN 296.A OE1 no hydrogen 2.803 N/A GLN 296.A NE2 ASP 349.A OD2 no hydrogen 2.863 N/A GLN 297.A N LEU 294.A O no hydrogen 2.911 N/A GLN 297.A NE2 VAL 347.A O no hydrogen 3.038 N/A TYR 298.A OH PRO 274.A O no hydrogen 2.645 N/A LEU 299.A N PRO 295.A O no hydrogen 2.726 N/A ARG 300.A N LYS 307.A O no hydrogen 2.851 N/A ARG 300.A NH2 SER 14.A OG no hydrogen 3.348 N/A VAL 302.A N CYS 305.A O no hydrogen 2.793 N/A ASP 304.A N TRP 263.A O no hydrogen 3.477 N/A TYR 306.A N VAL 261.A O no hydrogen 2.843 N/A TYR 306.A OH THR 268.A OG1 no hydrogen 3.296 N/A LYS 307.A N ARG 300.A O no hydrogen 2.783 N/A ALA 309.A N TYR 298.A O no hydrogen 2.791 N/A SER 311.A N LEU 227.A O no hydrogen 3.114 N/A SER 313.A OG THR 315.A OG1 no hydrogen 3.164 N/A SER 313.A OG GLY 316.A O no hydrogen 2.839 N/A THR 315.A N SER 313.A OG no hydrogen 2.965 N/A THR 315.A OG1 SER 313.A OG no hydrogen 3.164 N/A THR 317.A N LYS 217.A O no hydrogen 2.799 N/A THR 317.A OG1 TYR 213.A O no hydrogen 2.630 N/A VAL 318.A N ARG 228.A O no hydrogen 2.808 N/A MET 319.A N ILE 219.A O no hydrogen 2.744 N/A ALA 321.A N THR 224.A O no hydrogen 2.902 N/A VAL 322.A N THR 225.A O no hydrogen 2.995 N/A MET 324.A N GLY 320.A O no hydrogen 3.050 N/A GLU 325.A N ALA 321.A O no hydrogen 2.891 N/A GLY 326.A N ILE 323.A O no hydrogen 3.075 N/A PHE 327.A N MET 324.A O no hydrogen 3.242 N/A TYR 328.A N ALA 341.A O no hydrogen 2.769 N/A VAL 329.A N LEU 156.A O no hydrogen 3.072 N/A VAL 330.A N GLY 339.A O no hydrogen 2.755 N/A PHE 331.A N PHE 154.A O no hydrogen 2.804 N/A ASP 332.A N ARG 337.A O no hydrogen 2.893 N/A ARG 333.A NE ASN 152.A OD1 no hydrogen 2.935 N/A ARG 333.A NH1 TYR 192.A OH no hydrogen 2.802 N/A ARG 333.A NH2 ASP 142.A OD1 no hydrogen 2.738 N/A ALA 334.A N ASN 152.A O no hydrogen 2.874 N/A ARG 335.A N ASP 332.A OD1 no hydrogen 3.092 N/A LYS 336.A N ARG 333.A O no hydrogen 3.223 N/A ARG 337.A N ASP 332.A O no hydrogen 3.081 N/A ARG 337.A NE ASP 332.A OD2 no hydrogen 2.742 N/A ARG 337.A NH1 GLU 283.A OE2 no hydrogen 2.830 N/A ARG 337.A NH2 ASP 332.A OD2 no hydrogen 3.060 N/A ILE 338.A N THR 184.A O no hydrogen 2.824 N/A GLY 339.A N VAL 330.A O no hydrogen 2.794 N/A PHE 340.A N TRP 182.A O no hydrogen 2.795 N/A ALA 341.A N TYR 328.A O no hydrogen 3.188 N/A SER 343.A N GLY 326.A O no hydrogen 3.305 N/A ALA 344.A N LEU 176.A O no hydrogen 2.912 N/A CYS 345.A N SER 343.A OG no hydrogen 3.375 N/A CYS 345.A SG SER 343.A OG no hydrogen 3.407 N/A HIS 346.A ND1 SER 343.A O no hydrogen 3.219 N/A HIS 348.A ND1 ASP 349.A O no hydrogen 3.032 N/A ASP 349.A N ARG 352.A O no hydrogen 3.523 N/A PHE 351.A N ASP 349.A OD1 no hydrogen 3.171 N/A ARG 352.A N ASP 349.A OD1 no hydrogen 2.893 N/A ARG 352.A NH1 PHE 273.A O no hydrogen 2.838 N/A ARG 352.A NH2 PHE 273.A O no hydrogen 2.760 N/A ALA 354.A N HIS 346.A NE2 no hydrogen 2.932 N/A ALA 355.A N THR 292.A O no hydrogen 3.256 N/A GLU 357.A N ARG 290.A O no hydrogen 2.876 N/A PHE 360.A N SER 288.A O no hydrogen 2.954 N/A THR 362.A N ASN 286.A O no hydrogen 2.823 N/A THR 362.A OG1 SER 288.A OG no hydrogen 2.846 N/A ASP 367.A N ASP 364.A O no hydrogen 2.861 N/A CYS 368.A N MET 365.A O no hydrogen 3.122 N/A CYS 368.A SG MET 365.A O no hydrogen 3.456 N/A GLY 369.A N GLU 366.A O no hydrogen 3.242 N/A