Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4x2z_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 2.A N LEU 18.A O no hydrogen 2.987 N/A LYS 2.A NZ ALA 40.A O no hydrogen 2.636 N/A LYS 2.A NZ VAL 43.A O no hydrogen 2.564 N/A THR 3.A N ASP 45.A OD1 no hydrogen 2.676 N/A ILE 4.A N ILE 16.A O no hydrogen 2.856 N/A TYR 5.A N GLU 47.A O no hydrogen 2.968 N/A LEU 6.A N ARG 14.A O no hydrogen 2.875 N/A THR 7.A N LEU 49.A O no hydrogen 2.955 N/A THR 7.A OG1 LYS 12.A O no hydrogen 2.730 N/A ASP 9.A N THR 7.A OG1 no hydrogen 3.183 N/A GLY 10.A N THR 7.A OG1 no hydrogen 2.691 N/A VAL 11.A N ASP 9.A OD1 no hydrogen 2.806 N/A LYS 12.A N ASP 9.A OD1 no hydrogen 2.937 N/A ARG 14.A N LEU 6.A O no hydrogen 2.963 N/A ILE 16.A N ILE 4.A O no hydrogen 2.978 N/A LEU 18.A N LYS 2.A O no hydrogen 2.655 N/A LYS 19.A N ASP 22.A OD2 no hydrogen 2.887 N/A ASP 22.A N LYS 19.A O no hydrogen 2.981 N/A GLN 26.A NE2 SER 23.A O no hydrogen 3.282 N/A PHE 27.A N LEU 24.A O no hydrogen 3.029 N/A GLY 28.A N GLY 25.A O no hydrogen 3.017 N/A GLN 29.A NE2 VAL 30.A O no hydrogen 3.022 N/A TYR 31.A N TYR 50.A O no hydrogen 2.734 N/A LYS 33.A NZ TYR 50.A OH no hydrogen 2.944 N/A LYS 33.A NZ ASP 132.A OD1 no hydrogen 2.997 N/A ASN 34.A N LEU 76.A O no hydrogen 2.811 N/A ASN 34.A ND2 GLN 78.A O no hydrogen 2.927 N/A ASN 34.A ND2 THR 131.A OG1 no hydrogen 2.870 N/A LYS 35.A NZ ASP 42.A O no hydrogen 3.140 N/A LYS 35.A NZ GLU 47.A OE1 no hydrogen 2.838 N/A LYS 35.A NZ GLU 47.A OE2 no hydrogen 3.404 N/A PHE 38.A N ASP 42.A OD2 no hydrogen 2.782 N/A THR 39.A N ASP 42.A OD2 no hydrogen 2.913 N/A ASP 41.A N THR 39.A OG1 no hydrogen 3.248 N/A ASP 42.A N THR 39.A O no hydrogen 2.750 N/A VAL 43.A N ALA 40.A O no hydrogen 3.353 N/A GLU 44.A N GLU 47.A OE1 no hydrogen 2.792 N/A LYS 46.A N THR 3.A O no hydrogen 2.685 N/A GLU 47.A N GLU 44.A O no hydrogen 3.126 N/A LEU 49.A N TYR 5.A O no hydrogen 2.810 N/A TYR 50.A N TYR 31.A O no hydrogen 2.704 N/A VAL 51.A N THR 7.A O no hydrogen 2.968 N/A THR 53.A OG1 GLU 8.A OE1 no hydrogen 3.038 N/A ASP 55.A N THR 53.A OG1 no hydrogen 3.061 N/A SER 57.A N ASP 55.A OD1 no hydrogen 3.158 N/A SER 57.A OG ASP 55.A OD1 no hydrogen 2.915 N/A SER 57.A OG ASP 55.A OD2 no hydrogen 2.824 N/A LEU 59.A N ASP 55.A O no hydrogen 3.032 N/A GLU 60.A N LYS 56.A O no hydrogen 2.893 N/A TYR 61.A N SER 57.A O no hydrogen 2.835 N/A TYR 61.A OH GLU 120.A OE1 no hydrogen 3.302 N/A TYR 62.A N ILE 58.A O no hydrogen 2.933 N/A TYR 62.A OH ASP 9.A O no hydrogen 2.594 N/A GLY 63.A N LEU 59.A O no hydrogen 2.779 N/A LEU 64.A N LEU 59.A O no hydrogen 3.157 N/A LYS 68.A N ASP 65.A OD1 no hydrogen 2.766 N/A TYR 69.A N ASP 65.A O no hydrogen 2.943 N/A TYR 69.A OH GLU 8.A O no hydrogen 2.610 N/A VAL 70.A N ALA 66.A O no hydrogen 3.159 N/A ILE 71.A N GLN 67.A O no hydrogen 3.280 N/A TYR 72.A N LYS 68.A O no hydrogen 2.804 N/A LEU 73.A N TYR 69.A O no hydrogen 2.988 N/A GLN 74.A N VAL 70.A O no hydrogen 2.953 N/A THR 75.A N ILE 71.A O no hydrogen 3.051 N/A THR 75.A N TYR 72.A O no hydrogen 3.051 N/A THR 75.A OG1 ILE 71.A O no hydrogen 2.806 N/A LEU 76.A N TYR 72.A O no hydrogen 3.233 N/A LEU 76.A N LEU 73.A O no hydrogen 3.170 N/A GLN 78.A N THR 75.A O no hydrogen 3.187 N/A LYS 79.A NZ TRP 80.A O no hydrogen 3.077 N/A ASN 81.A ND2 GLU 92.A OE1 no hydrogen 3.188 N/A GLN 83.A N ILE 90.A O no hydrogen 2.895 N/A ARG 85.A N PHE 88.A O no hydrogen 2.707 N/A ARG 85.A NH2 ASP 272.A O no hydrogen 3.084 N/A ASN 87.A N ASN 87.A OD1 no hydrogen 2.465 N/A PHE 88.A N ARG 85.A O no hydrogen 2.819 N/A LEU 89.A N GLN 108.A OE1 no hydrogen 2.785 N/A ILE 90.A N GLN 83.A O no hydrogen 2.689 N/A LEU 91.A N SER 101.A OG no hydrogen 3.391 N/A GLU 92.A N ASN 81.A O no hydrogen 2.929 N/A ARG 94.A N ASN 97.A OD1 no hydrogen 3.157 N/A ARG 94.A NH1 GLN 78.A OE1 no hydrogen 3.050 N/A ARG 94.A NH1 ASP 95.A OD2 no hydrogen 2.777 N/A ARG 94.A NH2 GLN 78.A OE1 no hydrogen 3.127 N/A ARG 94.A NH2 LYS 79.A O no hydrogen 2.833 N/A ASN 97.A N ARG 94.A O no hydrogen 3.178 N/A ASN 97.A ND2 GLU 92.A O no hydrogen 3.014 N/A CYS 98.A SG HIS 261.A ND1 no hydrogen 3.313 N/A TRP 99.A NE1 ASP 147.A O no hydrogen 3.034 N/A SER 101.A N ASN 97.A O no hydrogen 2.957 N/A SER 101.A OG LEU 91.A O no hydrogen 3.505 N/A SER 102.A N CYS 98.A O no hydrogen 2.844 N/A SER 102.A OG CYS 98.A O no hydrogen 2.719 N/A ALA 103.A N TRP 99.A O no hydrogen 3.299 N/A ILE 104.A N ILE 100.A O no hydrogen 3.007 N/A VAL 105.A N SER 101.A O no hydrogen 3.047 N/A LEU 106.A N SER 102.A O no hydrogen 3.082 N/A LEU 107.A N ALA 103.A O no hydrogen 3.055 N/A GLN 108.A N ILE 104.A O no hydrogen 3.305 N/A GLN 108.A NE2 LEU 89.A O no hydrogen 2.874 N/A GLN 108.A NE2 ILE 104.A O no hydrogen 3.005 N/A ALA 109.A N VAL 105.A O no hydrogen 3.002 N/A ALA 110.A N LEU 106.A O no hydrogen 3.039 N/A LYS 111.A N GLN 108.A O no hydrogen 2.973 N/A ILE 112.A N LEU 107.A O no hydrogen 3.114 N/A LYS 115.A N HIS 161.A O no hydrogen 2.786 N/A THR 119.A N GLY 116.A O no hydrogen 3.221 N/A THR 119.A OG1 PHE 114.A O no hydrogen 2.729 N/A THR 119.A OG1 GLY 116.A O no hydrogen 3.569 N/A ALA 121.A N PHE 117.A O no hydrogen 3.386 N/A TRP 122.A N LEU 118.A O no hydrogen 2.897 N/A ALA 123.A N THR 119.A O no hydrogen 3.094 N/A LYS 124.A N GLU 120.A O no hydrogen 2.836 N/A LYS 124.A NZ ASP 132.A OD2 no hydrogen 2.986 N/A LEU 125.A N ALA 121.A O no hydrogen 2.960 N/A LEU 126.A N TRP 122.A O no hydrogen 2.848 N/A GLY 127.A N ALA 123.A O no hydrogen 2.963 N/A GLY 128.A N LEU 125.A O no hydrogen 2.814 N/A ASP 129.A N LYS 124.A O no hydrogen 2.827 N/A THR 131.A N ASP 129.A OD1 no hydrogen 3.330 N/A THR 131.A OG1 ASP 129.A OD1 no hydrogen 2.807 N/A VAL 134.A N PRO 130.A O no hydrogen 2.905 N/A ALA 135.A N THR 131.A O no hydrogen 3.034 N/A TRP 136.A N ASP 132.A O no hydrogen 3.061 N/A TRP 136.A NE1 TYR 62.A O no hydrogen 2.738 N/A CYS 137.A N PHE 133.A O no hydrogen 3.014 N/A CYS 137.A SG PHE 133.A O no hydrogen 3.345 N/A TYR 138.A N VAL 134.A O no hydrogen 3.152 N/A ALA 139.A N ALA 135.A O no hydrogen 3.076 N/A SER 140.A N TRP 136.A O no hydrogen 2.913 N/A SER 140.A OG CYS 137.A O no hydrogen 2.884 N/A CYS 141.A N TYR 138.A O no hydrogen 3.107 N/A CYS 141.A SG CYS 137.A O no hydrogen 3.823 N/A CYS 141.A SG SER 140.A OG no hydrogen 3.683 N/A THR 142.A N ALA 139.A O no hydrogen 2.942 N/A ALA 143.A N TYR 138.A O no hydrogen 2.876 N/A LYS 144.A N ASP 147.A OD2 no hydrogen 2.870 N/A ASP 147.A N LYS 144.A O no hydrogen 2.904 N/A ASN 152.A N ASP 150.A OD1 no hydrogen 2.843 N/A ASN 152.A ND2 ILE 287.A O no hydrogen 2.885 N/A LEU 154.A N ASP 150.A O no hydrogen 3.170 N/A LEU 155.A N ALA 151.A O no hydrogen 2.970 N/A ALA 156.A N ASN 152.A O no hydrogen 2.952 N/A ASN 157.A N TRP 153.A O no hydrogen 2.916 N/A ASN 157.A ND2 SER 140.A OG no hydrogen 3.078 N/A LEU 158.A N LEU 154.A O no hydrogen 2.897 N/A ALA 159.A N LEU 155.A O no hydrogen 2.809 N/A HIS 161.A N LEU 158.A O no hydrogen 2.842 N/A PHE 162.A N ALA 159.A O no hydrogen 3.116 N/A ASP 163.A N ARG 113.A O no hydrogen 2.636 N/A TYR 166.A N ALA 164.A O no hydrogen 2.881 N/A TYR 166.A OH ALA 159.A O no hydrogen 2.788 N/A TYR 166.A OH TYR 229.A OH no hydrogen 2.328 N/A ASN 168.A N ASP 165.A OD1 no hydrogen 3.412 N/A ALA 169.A N TYR 166.A O no hydrogen 3.285 N/A PHE 170.A N SER 226.A O no hydrogen 2.880 N/A LEU 171.A N LEU 186.A O no hydrogen 2.843 N/A LYS 172.A N GLU 224.A O no hydrogen 2.752 N/A LYS 173.A N TYR 184.A O no hydrogen 2.931 N/A LYS 173.A NZ ASP 220.A OD1 no hydrogen 2.767 N/A ARG 174.A N GLU 221.A O no hydrogen 2.748 N/A ARG 174.A NE GLU 221.A OE2 no hydrogen 3.386 N/A ARG 174.A NH2 GLU 221.A OE2 no hydrogen 3.472 N/A VAL 175.A N LYS 182.A O no hydrogen 2.744 N/A SER 176.A N THR 219.A O no hydrogen 2.863 N/A CYS 177.A N GLY 180.A O no hydrogen 3.051 N/A GLY 180.A N CYS 177.A O no hydrogen 3.088 N/A LYS 182.A N VAL 175.A O no hydrogen 2.730 N/A TYR 184.A N LYS 173.A O no hydrogen 3.120 N/A TYR 184.A OH ASP 220.A OD2 no hydrogen 2.676 N/A LEU 186.A N LEU 171.A O no hydrogen 2.785 N/A ARG 187.A NH2 GLU 185.A OE1 no hydrogen 3.487 N/A GLY 188.A N ALA 169.A O no hydrogen 3.076 N/A ALA 191.A N GLY 188.A O no hydrogen 3.118 N/A CYS 192.A N LEU 189.A O no hydrogen 3.034 N/A CYS 192.A SG GLY 188.A O no hydrogen 3.426 N/A ILE 193.A N LEU 189.A O no hydrogen 3.306 N/A GLN 194.A N LEU 231.A O no hydrogen 2.740 N/A GLN 194.A NE2 GLU 190.A O no hydrogen 3.063 N/A GLN 194.A NE2 ALA 191.A O no hydrogen 3.696 N/A GLN 194.A NE2 ILE 193.A O no hydrogen 3.136 N/A VAL 196.A N PHE 233.A O no hydrogen 2.837 N/A THR 199.A OG1 THR 199.A O no hydrogen 2.679 N/A ASN 200.A N ALA 198.A O no hydrogen 3.109 N/A ASN 200.A ND2 ASP 242.A O no hydrogen 2.976 N/A LEU 201.A N ASP 244.A OD2 no hydrogen 2.689 N/A HIS 203.A N ASN 200.A OD1 no hydrogen 3.215 N/A HIS 203.A ND1 ASN 200.A OD1 no hydrogen 3.042 N/A PHE 204.A N ASN 200.A O no hydrogen 3.108 N/A LYS 205.A N LEU 201.A O no hydrogen 2.854 N/A GLN 207.A N ASP 220.A O no hydrogen 2.833 N/A GLN 207.A NE2 HIS 203.A O no hydrogen 3.630 N/A GLN 207.A NE2 PHE 204.A O no hydrogen 3.179 N/A SER 209.A N ASN 218.A O no hydrogen 3.144 N/A SER 209.A OG ASN 210.A O no hydrogen 3.470 N/A ASN 210.A N SER 209.A OG no hydrogen 2.641 N/A ASN 210.A ND2 GLY 215.A O no hydrogen 2.357 N/A CYS 211.A N ALA 216.A O no hydrogen 2.886 N/A ASN 218.A N SER 209.A O no hydrogen 2.978 N/A THR 219.A N SER 176.A O no hydrogen 2.953 N/A ASP 220.A N GLN 207.A O no hydrogen 2.883 N/A GLU 221.A N ARG 174.A O no hydrogen 2.871 N/A VAL 222.A N LYS 205.A O no hydrogen 2.868 N/A ILE 223.A N LYS 172.A O no hydrogen 2.869 N/A GLU 224.A N LYS 172.A O no hydrogen 3.240 N/A ALA 225.A N PHE 295.A O no hydrogen 2.894 N/A SER 226.A N PHE 170.A O no hydrogen 2.920 N/A LEU 227.A N PHE 293.A O no hydrogen 2.778 N/A TYR 229.A OH TYR 166.A OH no hydrogen 2.328 N/A LEU 230.A N TYR 290.A O no hydrogen 2.773 N/A LEU 231.A N CYS 192.A O no hydrogen 2.729 N/A LEU 232.A N ALA 289.A O no hydrogen 2.898 N/A PHE 233.A N GLN 194.A O no hydrogen 2.987 N/A ALA 234.A N ILE 287.A O no hydrogen 2.866 N/A THR 235.A N VAL 196.A O no hydrogen 2.858 N/A THR 235.A OG1 VAL 196.A O no hydrogen 3.084 N/A THR 235.A OG1 ASP 236.A OD2 no hydrogen 2.884 N/A ALA 239.A N TYR 286.A O no hydrogen 3.092 N/A VAL 241.A N SER 284.A O no hydrogen 3.456 N/A CYS 243.A N LYS 282.A O no hydrogen 2.996 N/A CYS 243.A SG LYS 282.A O no hydrogen 3.605 N/A CYS 243.A SG TYR 286.A OH no hydrogen 3.342 N/A ALA 247.A N ASP 244.A O no hydrogen 3.337 N/A THR 250.A N GLN 265.A O no hydrogen 2.893 N/A VAL 251.A N THR 288.A O no hydrogen 2.942 N/A VAL 252.A N TYR 263.A O no hydrogen 2.725 N/A PHE 253.A N PRO 285.A O no hydrogen 3.039 N/A VAL 254.A N HIS 261.A O no hydrogen 2.988 N/A SER 256.A N SER 259.A O no hydrogen 3.073 N/A SER 259.A N SER 256.A OG no hydrogen 3.301 N/A HIS 261.A N VAL 254.A O no hydrogen 2.920 N/A HIS 261.A NE2 ASP 272.A OD1 no hydrogen 2.715 N/A HIS 261.A NE2 ASP 272.A OD2 no hydrogen 2.988 N/A TYR 263.A N VAL 252.A O no hydrogen 3.012 N/A THR 264.A N PHE 271.A O no hydrogen 3.407 N/A THR 264.A OG1 SER 102.A O no hydrogen 2.615 N/A GLN 265.A N THR 250.A O no hydrogen 2.821 N/A GLN 265.A NE2 GLY 281.A O no hydrogen 3.042 N/A ALA 266.A N GLN 269.A O no hydrogen 2.908 N/A GLN 269.A N ALA 266.A O no hydrogen 2.714 N/A GLN 269.A NE2 ASP 86.A OD2 no hydrogen 2.890 N/A PHE 271.A N THR 264.A O no hydrogen 2.761 N/A ASN 273.A ND2 LEU 91.A O no hydrogen 2.765 N/A ASN 273.A ND2 ASN 97.A OD1 no hydrogen 3.214 N/A LEU 274.A N ASP 272.A OD1 no hydrogen 2.998 N/A ALA 275.A N ASP 272.A OD1 no hydrogen 3.126 N/A ARG 278.A N ALA 275.A O no hydrogen 3.349 N/A ARG 278.A NE ASP 272.A OD2 no hydrogen 2.493 N/A ARG 278.A NH2 ASP 272.A OD2 no hydrogen 3.053 N/A GLY 281.A N GLN 265.A OE1 no hydrogen 2.879 N/A SER 284.A N VAL 241.A O no hydrogen 3.389 N/A SER 284.A OG GLY 281.A O no hydrogen 2.577 N/A TYR 286.A N ALA 239.A O no hydrogen 3.220 N/A TYR 286.A OH LYS 282.A O no hydrogen 2.835 N/A ILE 287.A N VAL 251.A O no hydrogen 2.966 N/A THR 288.A OG1 ASN 152.A OD1 no hydrogen 2.640 N/A ALA 289.A N LEU 232.A O no hydrogen 3.130 N/A TYR 290.A OH ASP 244.A OD2 no hydrogen 2.498 N/A ARG 292.A N PRO 228.A O no hydrogen 2.789 N/A PHE 293.A N LEU 227.A O no hydrogen 2.889 N/A PHE 295.A N ALA 225.A O no hydrogen 2.846 N/A LYS 296.A NZ GLU 298.A OE2 no hydrogen 2.762 N/A ASN 297.A N ILE 223.A O no hydrogen 2.925 N/A THR 299.A N ASN 297.A OD1 no hydrogen 3.259 N/A THR 299.A OG1 ASN 297.A OD1 no hydrogen 3.220 N/A