Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4x3o_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 5.A N SER 228.A OG.A no hydrogen 2.952 N/A ARG 6.A NE LEU 8.A O no hydrogen 3.044 N/A ARG 6.A NH2 ASP 9.A O no hydrogen 3.388 N/A THR 12.A OG1 GLU 10.A OE2 no hydrogen 2.714 N/A GLU 14.A N GLU 14.A OE1 no hydrogen 2.832 N/A GLY 15.A N THR 12.A OG1 no hydrogen 3.031 N/A VAL 16.A N THR 12.A O no hydrogen 3.009 N/A ALA 17.A N LEU 13.A O no hydrogen 2.882 N/A ARG 18.A N GLU 14.A O no hydrogen 3.085 N/A ARG 18.A NE ASP 9.A OD1 no hydrogen 3.348 N/A ARG 18.A NE ASP 9.A OD2 no hydrogen 2.795 N/A ARG 18.A NH2 ASP 9.A OD1 no hydrogen 2.940 N/A TYR 19.A N GLY 15.A O no hydrogen 3.018 N/A TYR 19.A OH ASP 204.A O no hydrogen 2.664 N/A MET 20.A N VAL 16.A O no hydrogen 2.845 N/A GLN 21.A N ALA 17.A O no hydrogen 3.127 N/A GLN 21.A NE2 LEU 278.A O no hydrogen 2.835 N/A SER 22.A N TYR 19.A O no hydrogen 3.071 N/A SER 22.A OG TYR 19.A O no hydrogen 2.689 N/A CYS 25.A N SER 22.A O no hydrogen 3.331 N/A ARG 26.A N.A ASP 204.A OD2 no hydrogen 2.925 N/A ARG 26.A N.B ASP 204.A OD2 no hydrogen 2.879 N/A ARG 26.A NE.A CYS 25.A O no hydrogen 3.287 N/A ARG 26.A NH2.A SER 22.A O no hydrogen 3.305 N/A ARG 27.A N.A ASP 204.A OD2 no hydrogen 2.982 N/A ARG 27.A N.B ASP 204.A OD2 no hydrogen 2.993 N/A ARG 27.A NE.B ASP 204.A OD2 no hydrogen 3.175 N/A ARG 27.A NH2.B ASP 204.A OD1 no hydrogen 3.163 N/A VAL 28.A N LEU 109.A O no hydrogen 2.809 N/A ILE 29.A N LEU 205.A O no hydrogen 2.961 N/A CYS 30.A N ARG 112.A O no hydrogen 2.997 N/A LEU 31.A N LEU 207.A O.A no hydrogen 2.901 N/A LEU 31.A N LEU 207.A O.B no hydrogen 2.739 N/A VAL 32.A N TYR 114.A O no hydrogen 2.983 N/A GLY 33.A N MET 209.A O no hydrogen 3.137 N/A GLY 35.A N GLY 210.A O no hydrogen 2.820 N/A ILE 36.A N GLY 33.A O no hydrogen 3.061 N/A SER 37.A N ALA 34.A O no hydrogen 3.055 N/A SER 37.A OG ASP 119.A OD2 no hydrogen 2.784 N/A THR 38.A OG1 GLY 35.A O no hydrogen 3.315 N/A SER 39.A OG.A ASP 268.A OD2 no hydrogen 2.782 N/A SER 39.A OG.B ASP 268.A OD2 no hydrogen 3.251 N/A ALA 40.A N SER 37.A O no hydrogen 2.988 N/A GLY 41.A N THR 38.A O no hydrogen 3.091 N/A ILE 42.A N SER 37.A O no hydrogen 3.345 N/A SER 47.A N ASP 44.A OD1 no hydrogen 3.051 N/A SER 47.A OG ASP 44.A OD1 no hydrogen 3.265 N/A SER 47.A OG ASP 44.A OD2 no hydrogen 2.486 N/A SER 49.A N ASP 54.A OD2 no hydrogen 2.690 N/A THR 50.A N PRO 48.A O no hydrogen 2.789 N/A GLY 51.A N SER 47.A O no hydrogen 2.883 N/A LEU 52.A N ASP 44.A O no hydrogen 2.753 N/A TYR 53.A N PHE 45.A O no hydrogen 3.037 N/A TYR 53.A OH GLU 65.A OE1 no hydrogen 2.962 N/A ASP 54.A N GLY 51.A O no hydrogen 3.066 N/A ASN 55.A N LEU 52.A O no hydrogen 2.825 N/A ASN 55.A ND2 SER 49.A O no hydrogen 2.854 N/A ASN 55.A ND2 GLY 51.A O no hydrogen 2.865 N/A LYS 58.A NZ GLU 86.A OE2 no hydrogen 2.774 N/A TYR 59.A N LEU 56.A O no hydrogen 3.072 N/A TYR 63.A OH GLU 69.A OE1 no hydrogen 2.563 N/A ALA 66.A N TYR 63.A O no hydrogen 3.198 N/A PHE 68.A N GLU 65.A O no hydrogen 3.123 N/A GLU 69.A N ALA 66.A O no hydrogen 3.067 N/A ILE 70.A N PHE 184.A O no hydrogen 3.006 N/A PHE 73.A N GLU 69.A O no hydrogen 3.003 N/A LYS 74.A N.A ILE 70.A O no hydrogen 2.909 N/A LYS 74.A N.B ILE 70.A O no hydrogen 2.953 N/A LYS 75.A N SER 71.A O no hydrogen 3.273 N/A HIS 76.A N TYR 72.A O no hydrogen 2.857 N/A GLU 78.A N GLU 78.A OE1 no hydrogen 2.818 N/A PHE 81.A N PRO 77.A O no hydrogen 3.201 N/A ALA 82.A N GLU 78.A O no hydrogen 2.892 N/A LEU 83.A N PRO 79.A O no hydrogen 2.881 N/A ALA 84.A N PHE 80.A O no hydrogen 2.856 N/A LYS 85.A N PHE 81.A O no hydrogen 3.111 N/A LYS 85.A NZ PHE 163.A O no hydrogen 3.086 N/A LYS 85.A NZ GLU 165.A OE2 no hydrogen 2.727 N/A GLU 86.A N ALA 82.A O no hydrogen 3.141 N/A LEU 87.A N LEU 83.A O no hydrogen 2.985 N/A TYR 88.A N ALA 84.A O no hydrogen 2.903 N/A GLN 91.A NE2 ASP 296.A OD1 no hydrogen 2.969 N/A LYS 93.A NZ ASP 296.A OD1 no hydrogen 2.698 N/A LYS 93.A NZ ASP 296.A OD2 no hydrogen 3.229 N/A THR 95.A N HIS 98.A ND1 no hydrogen 3.132 N/A THR 95.A OG1 ILE 36.A O no hydrogen 3.153 N/A THR 95.A OG1 HIS 98.A ND1 no hydrogen 2.849 N/A THR 95.A OG1 ASP 268.A OD1 no hydrogen 3.428 N/A CYS 97.A N.A ASP 268.A OD1 no hydrogen 3.098 N/A CYS 97.A N.B ASP 268.A OD1 no hydrogen 3.124 N/A CYS 97.A SG.B ASP 268.A OD1 no hydrogen 3.193 N/A HIS 98.A N THR 95.A OG1 no hydrogen 3.293 N/A HIS 98.A ND1 THR 95.A OG1 no hydrogen 2.849 N/A TYR 99.A N THR 95.A O no hydrogen 3.050 N/A PHE 100.A N ILE 96.A O no hydrogen 2.873 N/A MET 101.A N CYS 97.A O.A no hydrogen 3.222 N/A MET 101.A N CYS 97.A O.B no hydrogen 3.201 N/A ARG 102.A N HIS 98.A O no hydrogen 3.063 N/A ARG 102.A NE ASP 106.A OD1 no hydrogen 3.367 N/A ARG 102.A NE ASP 106.A OD2 no hydrogen 2.907 N/A ARG 102.A NH1 ALA 125.A O no hydrogen 2.895 N/A LEU 103.A N TYR 99.A O no hydrogen 2.939 N/A LEU 104.A N PHE 100.A O no hydrogen 2.975 N/A LYS 105.A N MET 101.A O no hydrogen 3.017 N/A LYS 105.A NZ GLU 128.A OE1 no hydrogen 2.854 N/A LYS 105.A NZ ASP 131.A OD2 no hydrogen 2.676 N/A ASP 106.A N ARG 102.A O no hydrogen 2.868 N/A LYS 107.A N LEU 103.A O no hydrogen 2.875 N/A LYS 107.A NZ GLU 283.A OE1 no hydrogen 3.562 N/A LYS 107.A NZ GLU 283.A OE2 no hydrogen 2.600 N/A GLY 108.A N LYS 105.A O no hydrogen 3.037 N/A LEU 109.A N LEU 104.A O no hydrogen 2.918 N/A LEU 110.A N LEU 104.A O no hydrogen 3.200 N/A LEU 111.A N VAL 28.A O no hydrogen 2.788 N/A ARG 112.A NE ASP 199.A OD2 no hydrogen 2.828 N/A ARG 112.A NH1 GLU 130.A O no hydrogen 2.644 N/A ARG 112.A NH2 ASP 199.A OD1 no hydrogen 2.855 N/A ARG 112.A NH2 ASP 199.A OD2 no hydrogen 3.529 N/A CYS 113.A N ASP 131.A O no hydrogen 2.803 N/A TYR 114.A N CYS 30.A O no hydrogen 2.814 N/A TYR 114.A OH ASP 199.A OD2 no hydrogen 2.659 N/A THR 115.A N VAL 133.A O no hydrogen 2.851 N/A THR 115.A OG1 GLU 122.A OE2 no hydrogen 2.678 N/A GLN 116.A N VAL 32.A O no hydrogen 2.995 N/A GLN 116.A NE2 VAL 32.A O no hydrogen 3.406 N/A GLN 116.A NE2 THR 211.A OG1 no hydrogen 2.952 N/A ASN 117.A N THR 115.A OG1 no hydrogen 2.967 N/A ASN 117.A ND2 GLY 33.A O no hydrogen 3.027 N/A THR 120.A OG1 ASP 119.A O no hydrogen 2.590 N/A LEU 121.A N ASP 119.A OD1 no hydrogen 2.981 N/A GLU 122.A N GLU 122.A OE1 no hydrogen 2.884 N/A ARG 123.A NE GLU 134.A OE2 no hydrogen 2.785 N/A ARG 123.A NH2 GLU 134.A OE1 no hydrogen 2.921 N/A ILE 124.A N THR 120.A O no hydrogen 3.123 N/A ALA 125.A N LEU 121.A O no hydrogen 2.936 N/A GLY 126.A N ARG 123.A O no hydrogen 2.989 N/A LEU 127.A N GLU 122.A O no hydrogen 3.020 N/A GLU 128.A N ASP 131.A OD2 no hydrogen 2.781 N/A GLU 130.A N GLU 130.A OE1 no hydrogen 2.869 N/A ASP 131.A N GLU 128.A O no hydrogen 2.954 N/A LEU 132.A N GLN 129.A O no hydrogen 3.442 N/A VAL 133.A N CYS 113.A O no hydrogen 2.826 N/A ALA 135.A N THR 115.A O no hydrogen 2.857 N/A GLY 137.A N GLU 134.A O no hydrogen 3.077 N/A THR 138.A N ASP 180.A O no hydrogen 2.890 N/A PHE 139.A N ILE 118.A O no hydrogen 3.074 N/A TYR 140.A N THR 138.A OG1 no hydrogen 2.885 N/A THR 141.A OG1 ASP 180.A OD2 no hydrogen 2.601 N/A SER 142.A N TYR 153.A O no hydrogen 2.937 N/A HIS 143.A N LYS 178.A O no hydrogen 2.940 N/A HIS 143.A ND1 ASP 180.A OD1 no hydrogen 2.722 N/A CYS 144.A N HIS 151.A O.A no hydrogen 2.970 N/A CYS 144.A N HIS 151.A O.B no hydrogen 2.882 N/A VAL 145.A N LEU 176.A O no hydrogen 2.910 N/A SER 146.A OG.B SER 175.A OG no hydrogen 2.557 N/A CYS 149.A N SER 146.A O.A no hydrogen 2.947 N/A CYS 149.A N SER 146.A O.B no hydrogen 2.962 N/A ARG 150.A N SER 146.A O.A no hydrogen 3.043 N/A ARG 150.A N SER 146.A O.B no hydrogen 3.041 N/A HIS 151.A ND1.A ASP 172.A OD2 no hydrogen 2.440 N/A TYR 153.A N SER 142.A O no hydrogen 2.828 N/A TRP 157.A N PRO 154.A O no hydrogen 3.065 N/A TRP 157.A NE1 GLU 171.A OE2 no hydrogen 2.893 N/A MET 158.A N PRO 154.A O no hydrogen 3.176 N/A LYS 159.A N LEU 155.A O no hydrogen 2.754 N/A GLU 160.A N SER 156.A O no hydrogen 3.241 N/A LYS 161.A N TRP 157.A O no hydrogen 3.207 N/A LYS 161.A NZ GLU 160.A OE1 no hydrogen 3.425 N/A ILE 162.A N MET 158.A O no hydrogen 2.963 N/A PHE 163.A N LYS 159.A O no hydrogen 2.937 N/A SER 164.A N GLU 160.A O no hydrogen 3.001 N/A SER 164.A OG GLU 160.A O no hydrogen 2.821 N/A SER 164.A OG GLU 160.A OE2 no hydrogen 2.738 N/A GLU 165.A N ILE 162.A O no hydrogen 3.263 N/A VAL 166.A N LYS 161.A O no hydrogen 3.126 N/A CYS 170.A N SER 175.A O no hydrogen 2.778 N/A CYS 170.A SG TYR 153.A OH no hydrogen 3.168 N/A GLU 171.A N TYR 153.A OH no hydrogen 2.823 N/A CYS 173.A SG SER 175.A OG no hydrogen 3.141 N/A GLN 174.A N CYS 170.A O no hydrogen 2.801 N/A SER 175.A OG SER 146.A OG.B no hydrogen 2.557 N/A VAL 177.A N PRO 168.A O no hydrogen 2.964 N/A LYS 178.A N HIS 143.A O no hydrogen 2.948 N/A LYS 178.A NZ PRO 179.A O no hydrogen 2.990 N/A LYS 178.A NZ ILE 181.A O no hydrogen 2.773 N/A ASP 180.A N THR 141.A O no hydrogen 2.960 N/A ILE 181.A N PRO 179.A O no hydrogen 2.732 N/A VAL 182.A N HIS 136.A O no hydrogen 2.858 N/A PHE 183.A N GLU 186.A OE1 no hydrogen 2.945 N/A PHE 184.A N PHE 68.A O no hydrogen 2.849 N/A GLU 186.A N PHE 183.A O no hydrogen 3.025 N/A ARG 191.A NH2 GLN 129.A OE1 no hydrogen 2.790 N/A PHE 192.A N PRO 189.A O no hydrogen 3.022 N/A PHE 193.A N ALA 190.A O no hydrogen 3.013 N/A SER 194.A N ALA 190.A O no hydrogen 3.124 N/A SER 194.A OG ALA 190.A O no hydrogen 3.545 N/A SER 194.A OG ARG 191.A O no hydrogen 3.339 N/A CYS 195.A N ARG 191.A O no hydrogen 2.941 N/A CYS 195.A SG ARG 191.A O no hydrogen 3.209 N/A MET 196.A N PHE 192.A O no hydrogen 2.966 N/A GLN 197.A N.A PHE 193.A O no hydrogen 3.046 N/A GLN 197.A N.B PHE 193.A O no hydrogen 3.025 N/A SER 198.A N SER 194.A O no hydrogen 3.448 N/A SER 198.A N CYS 195.A O no hydrogen 3.168 N/A ASP 199.A N CYS 195.A O no hydrogen 2.764 N/A PHE 200.A N MET 196.A O no hydrogen 3.357 N/A LEU 201.A N SER 198.A O no hydrogen 3.277 N/A LYS 202.A N ASP 199.A O no hydrogen 3.207 N/A ASP 204.A N ARG 27.A O.A no hydrogen 2.857 N/A ASP 204.A N ARG 27.A O.B no hydrogen 2.793 N/A LEU 205.A N ARG 27.A O.A no hydrogen 3.284 N/A LEU 205.A N ARG 27.A O.B no hydrogen 3.409 N/A LEU 206.A N.A PRO 230.A O no hydrogen 3.004 N/A LEU 206.A N.B PRO 230.A O no hydrogen 3.016 N/A LEU 207.A N.A ILE 29.A O no hydrogen 2.875 N/A LEU 207.A N.B ILE 29.A O no hydrogen 2.869 N/A VAL 208.A N LEU 232.A O no hydrogen 2.800 N/A MET 209.A N LEU 31.A O no hydrogen 2.885 N/A GLY 210.A N ILE 234.A O no hydrogen 3.248 N/A LEU 213.A N THR 211.A OG1 no hydrogen 3.096 N/A ALA 219.A N VAL 215.A O no hydrogen 2.909 N/A SER 220.A N GLN 216.A OE1 no hydrogen 3.062 N/A SER 220.A N PRO 217.A O no hydrogen 3.119 N/A SER 220.A OG PRO 217.A O no hydrogen 2.618 N/A LEU 221.A N PHE 218.A O no hydrogen 2.940 N/A ILE 222.A N ALA 219.A O no hydrogen 3.400 N/A SER 223.A N.A SER 220.A O no hydrogen 3.017 N/A SER 223.A N.B SER 220.A O no hydrogen 3.019 N/A SER 223.A OG.A SER 220.A O no hydrogen 2.763 N/A LYS 224.A N LEU 221.A O no hydrogen 3.074 N/A SER 228.A OG.A GLN 3.A O no hydrogen 2.681 N/A SER 228.A OG.A GLU 5.A O no hydrogen 3.484 N/A SER 228.A OG.A GLU 5.A OE2 no hydrogen 3.567 N/A THR 229.A N PRO 226.A O no hydrogen 2.992 N/A THR 229.A OG1 VAL 203.A O no hydrogen 2.966 N/A THR 229.A OG1 PRO 226.A O no hydrogen 3.467 N/A ARG 231.A N ARG 259.A O no hydrogen 3.005 N/A ARG 231.A NE ASP 260.A OD1 no hydrogen 2.810 N/A ARG 231.A NH1 ILE 222.A O no hydrogen 2.850 N/A ARG 231.A NH1 GLY 248.A O no hydrogen 2.810 N/A ARG 231.A NH2 GLY 248.A O no hydrogen 3.411 N/A ARG 231.A NH2 GLY 249.A O no hydrogen 3.020 N/A ARG 231.A NH2 ASP 260.A OD1 no hydrogen 3.452 N/A ARG 231.A NH2 ASP 260.A OD2 no hydrogen 2.863 N/A LEU 232.A N LEU 206.A O.A no hydrogen 2.875 N/A LEU 232.A N LEU 206.A O.B no hydrogen 2.954 N/A LEU 233.A N VAL 261.A O no hydrogen 2.818 N/A ILE 234.A N VAL 208.A O no hydrogen 2.855 N/A ASN 235.A N TRP 263.A O no hydrogen 3.187 N/A ASN 235.A ND2 GLU 237.A O.A no hydrogen 2.930 N/A ASN 235.A ND2 GLU 237.A O.B no hydrogen 2.909 N/A LYS 238.A NZ ASP 253.A OD1 no hydrogen 3.510 N/A LYS 238.A NZ ASP 253.A OD2 no hydrogen 2.672 N/A GLN 241.A N.A GLN 241.A OE1.A no hydrogen 2.882 N/A PHE 245.A N ASP 243.A OD2 no hydrogen 2.916 N/A LEU 246.A N ASP 243.A OD2 no hydrogen 2.965 N/A GLY 247.A N ASP 243.A O no hydrogen 2.987 N/A MET 250.A N.A GLY 240.A O no hydrogen 2.807 N/A MET 250.A N.B GLY 240.A O no hydrogen 2.816 N/A ASP 251.A N ASP 260.A OD2 no hydrogen 2.800 N/A SER 254.A N ASP 251.A OD1 no hydrogen 2.894 N/A SER 254.A OG ASP 251.A OD1 no hydrogen 3.276 N/A SER 254.A OG ASP 251.A OD2 no hydrogen 2.612 N/A LYS 256.A N SER 254.A OG no hydrogen 3.043 N/A ALA 257.A N SER 254.A O no hydrogen 3.000 N/A TYR 258.A OH LEU 227.A O no hydrogen 2.621 N/A ARG 259.A NH1 THR 229.A O no hydrogen 2.915 N/A VAL 261.A N ARG 231.A O no hydrogen 2.924 N/A TRP 263.A N LEU 233.A O no hydrogen 2.816 N/A GLY 265.A N ASN 235.A O no hydrogen 3.021 N/A CYS 267.A SG ILE 234.A O no hydrogen 3.570 N/A GLY 270.A N GLU 266.A O.A no hydrogen 2.968 N/A GLY 270.A N GLU 266.A O.B no hydrogen 2.956 N/A CYS 271.A N CYS 267.A O no hydrogen 2.939 N/A CYS 271.A SG CYS 267.A O no hydrogen 3.471 N/A LEU 272.A N ASP 268.A O no hydrogen 3.003 N/A ALA 273.A N GLN 269.A O no hydrogen 2.908 N/A LEU 274.A N GLY 270.A O no hydrogen 2.893 N/A ALA 275.A N CYS 271.A O no hydrogen 2.845 N/A GLU 276.A N LEU 272.A O no hydrogen 2.910 N/A LEU 277.A N ALA 273.A O no hydrogen 3.165 N/A LEU 278.A N LEU 274.A O no hydrogen 3.060 N/A GLY 279.A N GLU 276.A O no hydrogen 3.114 N/A TRP 280.A N ALA 275.A O no hydrogen 2.813 N/A LYS 281.A NZ GLU 276.A OE1 no hydrogen 3.117 N/A LYS 282.A NZ ASP 286.A OD2 no hydrogen 3.039 N/A LEU 284.A N TRP 280.A O no hydrogen 2.848 N/A GLU 285.A N LYS 281.A O no hydrogen 2.886 N/A ASP 286.A N LYS 282.A O no hydrogen 2.863 N/A LEU 287.A N GLU 283.A O no hydrogen 2.941 N/A VAL 288.A N LEU 284.A O no hydrogen 2.929 N/A ARG 289.A N GLU 285.A O no hydrogen 2.948 N/A ARG 290.A N ASP 286.A O no hydrogen 2.974 N/A GLU 291.A N LEU 287.A O no hydrogen 2.925 N/A HIS 292.A N VAL 288.A O no hydrogen 2.834 N/A HIS 292.A NE2 PRO 94.A O no hydrogen 2.747 N/A ALA 293.A N ARG 289.A O no hydrogen 2.968 N/A SER 294.A N ARG 290.A O no hydrogen 2.963 N/A ILE 295.A N GLU 291.A O no hydrogen 2.910 N/A ASP 296.A N HIS 292.A O no hydrogen 2.804 N/A ALA 297.A N ALA 293.A O no hydrogen 2.946 N/A GLN 298.A N ILE 295.A O no hydrogen 3.094 N/A