Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4zb4_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 4.A N GLU 8.A OE1 no hydrogen 2.721 N/A ARG 6.A NH1 ILE 180.A O no hydrogen 3.128 N/A GLU 8.A N THR 5.A OG1 no hydrogen 2.905 N/A PHE 9.A N THR 5.A O no hydrogen 3.060 N/A LEU 10.A N ARG 6.A O no hydrogen 2.821 N/A GLN 11.A N GLU 7.A O no hydrogen 3.314 N/A GLY 12.A N GLU 8.A O no hydrogen 3.213 N/A LEU 13.A N PHE 9.A O no hydrogen 2.945 N/A LEU 14.A N LEU 10.A O no hydrogen 3.097 N/A GLN 15.A N GLN 11.A O no hydrogen 3.072 N/A GLN 15.A NE2 GLN 15.A O no hydrogen 3.277 N/A GLN 15.A NE2 ASP 19.A OD1 no hydrogen 3.336 N/A SER 16.A N GLY 12.A O no hydrogen 3.108 N/A SER 17.A N LEU 13.A O no hydrogen 2.901 N/A SER 17.A OG ASP 198.A O no hydrogen 2.803 N/A ARG 18.A N LEU 14.A O no hydrogen 2.851 N/A ASP 19.A N GLN 15.A O no hydrogen 2.964 N/A PHE 20.A N SER 17.A O no hydrogen 3.349 N/A ARG 23.A N PHE 20.A O no hydrogen 3.156 N/A ARG 23.A NE ASP 19.A O no hydrogen 3.358 N/A LEU 26.A N MET 61.A O no hydrogen 3.094 N/A LYS 35.A N THR 353.A O no hydrogen 3.068 N/A ASN 36.A N THR 353.A O no hydrogen 2.998 N/A GLU 38.A N ALA 351.A O no hydrogen 2.987 N/A LEU 40.A N ILE 349.A O no hydrogen 2.725 N/A GLN 43.A N PHE 347.A O no hydrogen 3.031 N/A TYR 45.A N ASP 345.A O no hydrogen 3.359 N/A TYR 45.A OH THR 343.A O no hydrogen 3.167 N/A SER 46.A N CYS 70.A O no hydrogen 2.813 N/A ASN 48.A ND2 HIS 102.A ND1 no hydrogen 3.636 N/A ILE 49.A N SER 46.A O no hydrogen 3.253 N/A LYS 50.A N ALA 104.A O no hydrogen 3.132 N/A THR 51.A OG1 CYS 68.A O no hydrogen 2.774 N/A PHE 52.A N ILE 106.A O no hydrogen 3.346 N/A TYR 54.A N TRP 66.A O no hydrogen 3.035 N/A TYR 54.A OH ASN 152.A OD1 no hydrogen 2.478 N/A LYS 55.A N TYR 149.A OH no hydrogen 3.227 N/A LYS 55.A NZ ASP 239.A OD1 no hydrogen 2.950 N/A LYS 55.A NZ ASP 285.A OD2 no hydrogen 2.632 N/A GLU 56.A N ASP 64.A O no hydrogen 3.035 N/A LEU 57.A N GLU 153.A OE2 no hydrogen 2.754 N/A ASN 58.A N TYR 62.A O no hydrogen 3.005 N/A ASN 58.A ND2 ASP 64.A OD1 no hydrogen 3.371 N/A SER 60.A N ASN 58.A OD1 no hydrogen 2.827 N/A MET 61.A N ASN 58.A O no hydrogen 3.074 N/A TYR 62.A N ASN 58.A OD1 no hydrogen 3.227 N/A ASP 64.A N GLU 56.A O no hydrogen 2.791 N/A LYS 65.A NZ ASP 285.A OD1 no hydrogen 2.652 N/A TRP 66.A N TYR 54.A O no hydrogen 2.861 N/A VAL 67.A N LEU 82.A O no hydrogen 2.962 N/A CYS 68.A SG MET 69.A O no hydrogen 3.777 N/A MET 69.A N THR 80.A O no hydrogen 3.060 N/A ARG 71.A N HIS 78.A O no hydrogen 2.793 N/A ARG 71.A NH1 GLN 43.A OE1 no hydrogen 2.908 N/A ARG 71.A NH1 ASN 44.A O no hydrogen 3.223 N/A CYS 72.A N SER 46.A OG no hydrogen 3.255 N/A CYS 72.A SG GLY 100.A O no hydrogen 3.971 N/A GLU 73.A N ALA 76.A O no hydrogen 3.100 N/A ALA 76.A N GLU 73.A O no hydrogen 2.766 N/A LEU 77.A N THR 93.A O no hydrogen 2.721 N/A HIS 78.A N ARG 71.A O no hydrogen 2.754 N/A HIS 78.A ND1 THR 92.A OG1 no hydrogen 2.970 N/A PHE 79.A N ILE 91.A O no hydrogen 2.728 N/A THR 80.A N MET 69.A O no hydrogen 2.986 N/A GLN 81.A N THR 89.A O no hydrogen 3.011 N/A LEU 82.A N VAL 67.A O no hydrogen 3.256 N/A LYS 83.A N THR 87.A OG1 no hydrogen 3.114 N/A LYS 83.A NZ ASP 84.A OD2 no hydrogen 2.903 N/A ASP 84.A N THR 87.A OG1 no hydrogen 3.082 N/A SER 85.A N GLY 336.A O no hydrogen 3.138 N/A LYS 86.A N ASP 84.A OD1 no hydrogen 3.173 N/A THR 87.A OG1 ASP 84.A O no hydrogen 3.517 N/A THR 87.A OG1 ASP 84.A OD1 no hydrogen 2.558 N/A THR 89.A N GLN 81.A O no hydrogen 3.134 N/A ILE 91.A N PHE 79.A O no hydrogen 2.806 N/A THR 92.A OG1 HIS 78.A ND1 no hydrogen 2.970 N/A THR 93.A N LEU 77.A O no hydrogen 2.991 N/A ASN 95.A N GLY 75.A O no hydrogen 2.848 N/A ASN 95.A ND2 GLU 101.A O no hydrogen 2.888 N/A ARG 97.A N ASN 95.A OD1 no hydrogen 3.258 N/A GLU 101.A N THR 98.A O no hydrogen 3.261 N/A ALA 104.A N LEU 117.A O no hydrogen 2.680 N/A ILE 105.A N LEU 117.A O no hydrogen 3.494 N/A ILE 106.A N LYS 50.A O no hydrogen 2.820 N/A SER 107.A N LEU 115.A O no hydrogen 3.054 N/A SER 107.A OG MET 148.A O no hydrogen 2.650 N/A ARG 108.A NH1 GLN 81.A OE1 no hydrogen 3.318 N/A GLY 109.A N ARG 113.A O no hydrogen 2.863 N/A ARG 113.A N GLY 109.A O no hydrogen 3.331 N/A ARG 113.A NH1 PRO 110.A O no hydrogen 3.136 N/A LEU 114.A N LEU 126.A O no hydrogen 2.691 N/A LEU 115.A N SER 107.A O no hydrogen 2.677 N/A LEU 116.A N THR 124.A O no hydrogen 2.812 N/A LEU 117.A N ILE 105.A O no hydrogen 2.932 N/A TYR 118.A N GLN 122.A O no hydrogen 2.795 N/A TYR 118.A OH ASN 95.A OD1 no hydrogen 2.660 N/A ASN 121.A ND2 SER 141.A O no hydrogen 3.035 N/A ASN 121.A ND2 ASN 143.A O no hydrogen 2.857 N/A GLN 122.A N TYR 118.A O no hydrogen 3.191 N/A ILE 123.A N ILE 137.A O no hydrogen 2.626 N/A THR 124.A N LEU 116.A O no hydrogen 2.820 N/A THR 124.A OG1 GLU 136.A OE1 no hydrogen 3.153 N/A ILE 125.A N ARG 135.A O no hydrogen 3.085 N/A LEU 126.A N LEU 114.A O no hydrogen 2.899 N/A ASP 127.A N LYS 132.A O no hydrogen 3.001 N/A SER 128.A N ASN 112.A O no hydrogen 2.995 N/A SER 128.A OG ASN 112.A O no hydrogen 3.478 N/A LYS 129.A N ASP 127.A OD1 no hydrogen 2.815 N/A THR 130.A N ASP 127.A OD1 no hydrogen 3.282 N/A ASN 131.A N ASP 127.A O no hydrogen 2.731 N/A LEU 134.A N ILE 125.A O no hydrogen 2.747 N/A ARG 135.A N ILE 125.A O no hydrogen 3.365 N/A ARG 135.A NH1 SER 172.A O no hydrogen 3.071 N/A ARG 135.A NH1 TYR 173.A O no hydrogen 2.942 N/A ARG 135.A NH1 ASP 175.A O no hydrogen 3.168 N/A ILE 137.A N ILE 123.A O no hydrogen 2.733 N/A VAL 139.A N ASN 121.A O no hydrogen 3.105 N/A SER 141.A OG ASP 163.A OD2 no hydrogen 2.853 N/A ILE 145.A N ASN 121.A OD1 no hydrogen 3.004 N/A ILE 146.A N ALA 162.A O no hydrogen 2.810 N/A TYR 147.A N ALA 162.A O no hydrogen 3.176 N/A TYR 149.A N ILE 160.A O no hydrogen 2.887 N/A TYR 149.A OH PRO 53.A O no hydrogen 3.403 N/A HIS 151.A NE2 LYS 197.A O no hydrogen 2.908 N/A ASN 152.A ND2 GLU 153.A OE2 no hydrogen 2.848 N/A GLU 153.A N HIS 151.A ND1 no hydrogen 3.087 N/A VAL 154.A N HIS 151.A ND1 no hydrogen 3.066 N/A ASN 155.A N SER 16.A OG no hydrogen 2.836 N/A TYR 158.A N ASN 155.A O no hydrogen 3.206 N/A PHE 159.A N GLN 171.A O no hydrogen 2.947 N/A ILE 160.A N TYR 149.A O no hydrogen 2.651 N/A TRP 161.A N GLY 169.A O no hydrogen 3.065 N/A ALA 162.A N TYR 147.A O no hydrogen 2.989 N/A ASP 163.A N THR 167.A O no hydrogen 3.083 N/A ASN 164.A N GLU 144.A O no hydrogen 2.900 N/A ARG 165.A N ASP 163.A OD1 no hydrogen 3.121 N/A ARG 165.A NE GLU 189.A OE1 no hydrogen 3.057 N/A ARG 165.A NH2 GLU 189.A OE1 no hydrogen 2.585 N/A GLY 166.A N ASP 163.A O no hydrogen 3.255 N/A THR 167.A N ASP 163.A OD1 no hydrogen 2.823 N/A THR 167.A OG1 ASP 163.A OD1 no hydrogen 3.512 N/A THR 167.A OG1 ASP 163.A OD2 no hydrogen 3.040 N/A ILE 168.A N HIS 182.A O no hydrogen 2.868 N/A GLY 169.A N TRP 161.A O no hydrogen 3.110 N/A PHE 170.A N TYR 179.A O no hydrogen 2.845 N/A GLN 171.A N PHE 159.A O no hydrogen 2.935 N/A GLN 171.A NE2 SER 172.A O no hydrogen 2.878 N/A SER 172.A N SER 177.A O no hydrogen 2.956 N/A SER 172.A OG ASP 175.A O no hydrogen 3.531 N/A TYR 173.A N GLU 157.A O no hydrogen 2.974 N/A GLU 174.A N SER 172.A OG no hydrogen 3.321 N/A ASP 175.A N SER 172.A OG no hydrogen 2.961 N/A TYR 179.A N PHE 170.A O no hydrogen 3.025 N/A TYR 179.A OH ALA 3.A O no hydrogen 2.855 N/A VAL 181.A N ILE 168.A O no hydrogen 2.878 N/A HIS 182.A N ILE 168.A O no hydrogen 3.364 N/A HIS 182.A NE2 ASN 215.A O no hydrogen 2.784 N/A LYS 185.A N ARG 165.A O no hydrogen 3.250 N/A TYR 190.A N ASN 164.A O no hydrogen 2.955 N/A TYR 190.A OH ASP 212.A OD2 no hydrogen 2.734 N/A TYR 190.A OH TYR 214.A OH no hydrogen 2.651 N/A SER 191.A N TYR 205.A O no hydrogen 2.810 N/A SER 191.A OG TYR 205.A O no hydrogen 3.383 N/A SER 192.A N TYR 205.A O no hydrogen 3.227 N/A SER 192.A OG TYR 205.A OH no hydrogen 3.400 N/A GLY 193.A N SER 192.A OG no hydrogen 2.628 N/A VAL 194.A N ALA 203.A O no hydrogen 2.998 N/A HIS 196.A N LEU 201.A O no hydrogen 2.938 N/A HIS 196.A NE2 GLY 241.A O no hydrogen 2.817 N/A LYS 197.A NZ PHE 20.A O no hydrogen 3.101 N/A LYS 197.A NZ ARG 23.A O no hydrogen 3.200 N/A LYS 197.A NZ TYR 63.A OH no hydrogen 3.311 N/A LYS 197.A NZ ASP 198.A OD1 no hydrogen 2.734 N/A ASP 198.A N HIS 196.A ND1 no hydrogen 3.049 N/A SER 199.A N HIS 196.A O no hydrogen 2.848 N/A SER 199.A OG SER 199.A O no hydrogen 2.509 N/A LEU 202.A N TYR 214.A O no hydrogen 2.970 N/A ALA 203.A N VAL 194.A O no hydrogen 2.992 N/A LEU 204.A N ASP 212.A O no hydrogen 2.827 N/A TYR 205.A N SER 192.A O no hydrogen 3.196 N/A SER 206.A N ILE 210.A O no hydrogen 3.202 N/A ASP 212.A N LEU 204.A O no hydrogen 2.935 N/A VAL 213.A N SER 224.A O no hydrogen 2.859 N/A TYR 214.A N LEU 202.A O no hydrogen 2.729 N/A TYR 214.A OH TYR 190.A OH no hydrogen 2.651 N/A LEU 216.A N LEU 200.A O no hydrogen 2.791 N/A SER 217.A N ASN 215.A OD1 no hydrogen 3.134 N/A SER 217.A OG ASN 215.A OD1 no hydrogen 2.860 N/A SER 218.A OG GLN 221.A OE1 no hydrogen 3.109 N/A ASP 220.A N VAL 181.A O no hydrogen 2.884 N/A GLN 221.A N SER 218.A O no hydrogen 3.294 N/A SER 224.A N VAL 213.A O no hydrogen 3.041 N/A ARG 225.A NE ASP 212.A OD1 no hydrogen 2.921 N/A ARG 225.A NH1 ASP 187.A OD2 no hydrogen 3.027 N/A ARG 225.A NH2 ASP 187.A OD2 no hydrogen 3.191 N/A ARG 225.A NH2 ASP 212.A OD2 no hydrogen 3.146 N/A PHE 226.A N LEU 211.A O no hydrogen 2.888 N/A LYS 231.A NZ ASP 208.A OD1 no hydrogen 2.589 N/A ILE 232.A N PRO 207.A O no hydrogen 2.911 N/A LYS 233.A N GLU 247.A O no hydrogen 2.893 N/A LYS 233.A NZ GLU 247.A OE1 no hydrogen 3.197 N/A LYS 233.A NZ TYR 281.A O no hydrogen 2.961 N/A GLU 234.A N GLU 247.A O no hydrogen 3.240 N/A VAL 235.A N TYR 205.A OH no hydrogen 3.449 N/A LYS 236.A N VAL 245.A O no hydrogen 2.801 N/A LYS 236.A NZ GLU 234.A OE1 no hydrogen 3.275 N/A LYS 236.A NZ GLU 234.A OE2 no hydrogen 3.354 N/A LYS 236.A NZ ASP 282.A OD1 no hydrogen 2.992 N/A LYS 236.A NZ ILE 283.A O no hydrogen 3.251 N/A ALA 238.A N TRP 243.A O no hydrogen 3.017 N/A ASP 239.A N ASP 285.A O no hydrogen 2.824 N/A GLY 241.A N ALA 238.A O no hydrogen 3.056 N/A TYR 242.A N ASN 240.A OD1 no hydrogen 3.050 N/A TRP 243.A N ASN 240.A OD1 no hydrogen 3.204 N/A MET 244.A N PHE 255.A O no hydrogen 3.007 N/A VAL 245.A N LYS 236.A O no hydrogen 2.722 N/A VAL 246.A N VAL 253.A O no hydrogen 2.599 N/A GLU 247.A N GLU 234.A O no hydrogen 2.811 N/A CYS 248.A N THR 251.A O no hydrogen 2.897 N/A CYS 248.A SG VAL 246.A O no hydrogen 3.888 N/A ASP 249.A N LYS 231.A O no hydrogen 3.058 N/A VAL 252.A N TYR 269.A O no hydrogen 2.768 N/A VAL 253.A N VAL 246.A O no hydrogen 3.084 N/A PHE 255.A N MET 244.A O no hydrogen 2.942 N/A ASP 256.A N THR 263.A O no hydrogen 2.931 N/A LEU 257.A N TYR 242.A O no hydrogen 2.756 N/A ARG 258.A N ASP 256.A OD1 no hydrogen 3.004 N/A ARG 258.A NE ASP 256.A OD1 no hydrogen 2.915 N/A ARG 258.A NH2 ASP 256.A OD2 no hydrogen 2.742 N/A LYS 259.A N ASP 256.A O no hydrogen 3.228 N/A THR 263.A N ASP 260.A O no hydrogen 2.979 N/A THR 263.A OG1 ASP 260.A O no hydrogen 2.630 N/A ALA 265.A N CYS 254.A O no hydrogen 2.808 N/A TYR 269.A N VAL 252.A O no hydrogen 3.075 N/A ILE 271.A N GLN 250.A O no hydrogen 2.906 N/A LYS 275.A NZ PHE 274.A O no hydrogen 3.356 N/A THR 276.A OG1 THR 276.A O no hydrogen 2.389 N/A VAL 279.A N GLY 277.A O no hydrogen 3.017 N/A THR 280.A N TYR 293.A O no hydrogen 3.189 N/A TYR 281.A OH CYS 248.A O no hydrogen 2.645 N/A ASP 282.A N ILE 291.A O no hydrogen 3.046 N/A ILE 283.A N GLU 247.A OE2 no hydrogen 2.942 N/A ASP 284.A N ASN 289.A O no hydrogen 3.034 N/A SER 286.A OG ASP 284.A OD1 no hydrogen 2.887 N/A SER 286.A OG ASP 284.A OD2 no hydrogen 2.857 N/A GLY 287.A N ASP 284.A O no hydrogen 3.114 N/A LYS 288.A N SER 286.A OG no hydrogen 3.313 N/A ASN 289.A N ASP 284.A OD1 no hydrogen 3.242 N/A ASN 289.A ND2 ASP 284.A OD2 no hydrogen 3.045 N/A MET 290.A N TYR 303.A O no hydrogen 3.046 N/A ILE 291.A N ASP 282.A O no hydrogen 3.132 N/A ALA 292.A N THR 301.A O no hydrogen 2.790 N/A TYR 293.A N THR 280.A O no hydrogen 2.752 N/A SER 294.A N SER 299.A O no hydrogen 3.114 N/A SER 294.A OG SER 297.A OG no hydrogen 3.342 N/A ASN 295.A ND2 PHE 325.A O no hydrogen 2.687 N/A SER 297.A OG SER 294.A OG no hydrogen 3.342 N/A ASN 298.A ND2 TYR 293.A OH no hydrogen 3.555 N/A SER 299.A OG LEU 320.A O no hydrogen 2.794 N/A LEU 300.A N LEU 320.A O no hydrogen 2.857 N/A THR 301.A N ALA 292.A O no hydrogen 2.725 N/A TYR 303.A N MET 290.A O no hydrogen 2.819 N/A LYS 304.A N THR 313.A O no hydrogen 3.108 N/A LYS 304.A NZ PHE 305.A O no hydrogen 2.755 N/A PHE 305.A N LYS 288.A O no hydrogen 2.936 N/A ASP 306.A N ASN 311.A O no hydrogen 3.182 N/A LYS 308.A N ASP 306.A OD1 no hydrogen 2.849 N/A THR 309.A OG1 ASN 311.A OD1 no hydrogen 3.153 N/A LYS 310.A N ASP 306.A O no hydrogen 2.717 N/A TRP 312.A NE1 TYR 266.A OH no hydrogen 3.207 N/A THR 313.A N LYS 304.A O no hydrogen 3.180 N/A ASP 315.A N ILE 302.A O no hydrogen 2.776 N/A GLU 316.A N GLU 316.A OE1 no hydrogen 2.655 N/A GLU 317.A N ASP 315.A OD1 no hydrogen 3.345 N/A SER 318.A N ASP 315.A O no hydrogen 3.310 N/A SER 318.A OG LEU 34.A O no hydrogen 2.892 N/A SER 318.A OG ASP 315.A OD2 no hydrogen 3.529 N/A CYS 321.A SG ASN 298.A O no hydrogen 3.728 N/A LEU 322.A N ASN 298.A O no hydrogen 2.962 N/A PHE 325.A N ASN 295.A OD1 no hydrogen 3.027 N/A THR 326.A N LYS 342.A O no hydrogen 2.833 N/A ASP 327.A N LYS 342.A O no hydrogen 3.365 N/A ASP 329.A N ILE 340.A O no hydrogen 3.017 N/A VAL 330.A N ASP 282.A OD2 no hydrogen 3.012 N/A VAL 331.A N ALA 338.A O no hydrogen 2.982 N/A GLY 333.A N LYS 83.A O no hydrogen 2.983 N/A GLY 335.A N ASP 84.A OD2 no hydrogen 3.017 N/A GLY 336.A N GLY 333.A O no hydrogen 3.325 N/A ALA 338.A N VAL 331.A O no hydrogen 2.978 N/A ALA 339.A N VAL 350.A O no hydrogen 2.849 N/A ILE 340.A N ASP 329.A O no hydrogen 2.797 N/A LEU 341.A N ASN 348.A O no hydrogen 2.857 N/A LYS 342.A N ASP 327.A O no hydrogen 2.871 N/A LYS 342.A NZ ASP 329.A OD2 no hydrogen 2.498 N/A THR 343.A N SER 346.A O no hydrogen 2.768 N/A THR 343.A OG1 SER 346.A O no hydrogen 3.389 N/A THR 343.A OG1 SER 346.A OG no hydrogen 2.998 N/A ASP 345.A N THR 343.A OG1 no hydrogen 3.174 N/A SER 346.A OG THR 343.A OG1 no hydrogen 2.998 N/A PHE 347.A N GLN 43.A O no hydrogen 2.822 N/A ASN 348.A N LEU 341.A O no hydrogen 2.754 N/A ILE 349.A N GLN 41.A O no hydrogen 2.952 N/A VAL 350.A N ALA 339.A O no hydrogen 2.850 N/A ALA 351.A N GLU 38.A O no hydrogen 2.924 N/A LEU 352.A N ILE 337.A O no hydrogen 2.829 N/A THR 353.A N ASN 36.A O no hydrogen 3.140 N/A