Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 5twp_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): TYR 4.A N GLN 7.A OE1 no hydrogen 3.169 N/A TYR 4.A OH GLU 282.A OE2 no hydrogen 2.445 N/A ALA 5.A N GLU 274.A OE1 no hydrogen 2.961 N/A CYS 6.A SG GLU 274.A O no hydrogen 3.913 N/A GLN 7.A N TYR 4.A O no hydrogen 3.012 N/A ARG 8.A N ALA 5.A O no hydrogen 3.419 N/A ARG 8.A NH1 PRO 2.A O no hydrogen 2.849 N/A THR 10.A N GLN 322.A O no hydrogen 2.842 N/A ASN 16.A N HIS 14.A ND1 no hydrogen 3.113 N/A ASN 16.A ND2 LEU 49.A O no hydrogen 3.276 N/A ASN 16.A ND2 SER 54.A O no hydrogen 3.022 N/A SER 20.A N ASN 16.A O no hydrogen 3.012 N/A SER 20.A OG.A ASN 16.A O no hydrogen 3.304 N/A SER 20.A OG.A THR 17.A O no hydrogen 2.919 N/A SER 20.A OG.B ALA 46.A O no hydrogen 2.752 N/A GLU 21.A N THR 17.A O no hydrogen 2.966 N/A ALA 22.A N GLY 18.A O no hydrogen 3.196 N/A LEU 23.A N LEU 19.A O no hydrogen 3.165 N/A GLU 24.A N SER 20.A O no hydrogen 2.910 N/A ILE 25.A N GLU 21.A O no hydrogen 3.036 N/A LEU 26.A N ALA 22.A O no hydrogen 3.351 N/A ALA 27.A N LEU 23.A O no hydrogen 2.949 N/A GLU 28.A N GLU 24.A O no hydrogen 2.956 N/A ALA 29.A N ILE 25.A O no hydrogen 2.944 N/A ALA 30.A N LEU 26.A O no hydrogen 2.964 N/A GLY 31.A N ALA 27.A O no hydrogen 3.060 N/A PHE 32.A N GLU 28.A O no hydrogen 3.033 N/A GLU 33.A N ALA 30.A O no hydrogen 3.078 N/A GLY 34.A N GLY 31.A O no hydrogen 3.119 N/A SER 35.A N ALA 30.A O no hydrogen 2.908 N/A GLU 36.A N GLY 34.A O no hydrogen 3.136 N/A LEU 39.A N SER 35.A O no hydrogen 3.036 N/A LEU 40.A N GLU 36.A O no hydrogen 3.018 N/A THR 41.A N GLY 37.A O no hydrogen 3.044 N/A PHE 42.A N ARG 38.A O no hydrogen 2.957 N/A CYS 43.A N LEU 39.A O no hydrogen 2.849 N/A CYS 43.A SG LEU 39.A O no hydrogen 3.513 N/A ARG 44.A N LEU 40.A O no hydrogen 2.862 N/A ARG 44.A NE GLU 274.A OE2 no hydrogen 3.037 N/A ALA 45.A N THR 41.A O no hydrogen 2.894 N/A ALA 46.A N PHE 42.A O no hydrogen 3.017 N/A SER 47.A N CYS 43.A O no hydrogen 2.961 N/A SER 47.A OG.A ALA 325.A OXT no hydrogen 3.131 N/A SER 47.A OG.B ARG 44.A O no hydrogen 2.776 N/A VAL 48.A N ARG 44.A O no hydrogen 2.920 N/A LEU 49.A N ALA 45.A O no hydrogen 3.283 N/A LYS 50.A N ALA 46.A O no hydrogen 3.229 N/A LYS 50.A NZ GLU 24.A OE2 no hydrogen 2.713 N/A LYS 50.A NZ ALA 325.A OXT no hydrogen 2.977 N/A ALA 51.A N SER 47.A O no hydrogen 3.129 N/A ALA 51.A N VAL 48.A O no hydrogen 3.070 N/A LEU 52.A N LEU 49.A O no hydrogen 3.369 N/A VAL 56.A N ASN 16.A OD1 no hydrogen 2.696 N/A THR 57.A N GLN 61.A OE1 no hydrogen 2.618 N/A THR 57.A OG1 GLN 61.A OE1 no hydrogen 3.271 N/A THR 58.A N GLN 61.A OE1 no hydrogen 3.038 N/A THR 58.A OG1 SER 60.A OG no hydrogen 3.327 N/A SER 60.A OG THR 58.A OG1 no hydrogen 3.327 N/A GLN 61.A N THR 58.A O no hydrogen 3.060 N/A LEU 62.A N LEU 59.A O no hydrogen 2.884 N/A GLN 63.A N SER 60.A O no hydrogen 3.142 N/A LEU 65.A N LEU 62.A O no hydrogen 3.009 N/A HIS 67.A NE2 ALA 3.A O no hydrogen 2.839 N/A PHE 68.A N LEU 65.A O no hydrogen 3.465 N/A HIS 71.A NE2 GLU 87.A OE1 no hydrogen 2.692 N/A SER 73.A N GLY 69.A O no hydrogen 3.071 N/A SER 73.A OG GLY 69.A O no hydrogen 2.838 N/A ARG 74.A N GLU 70.A O no hydrogen 3.109 N/A ARG 74.A NH1 GLU 87.A OE1 no hydrogen 3.160 N/A ARG 74.A NH2 GLU 87.A OE1 no hydrogen 3.277 N/A VAL 75.A N HIS 71.A O no hydrogen 3.037 N/A VAL 76.A N SER 72.A O no hydrogen 3.077 N/A GLN 77.A N SER 73.A O no hydrogen 2.767 N/A GLN 77.A NE2 GLU 81.A OE2 no hydrogen 2.944 N/A GLU 78.A N ARG 74.A O no hydrogen 2.985 N/A LEU 79.A N VAL 75.A O no hydrogen 3.196 N/A LEU 80.A N VAL 76.A O no hydrogen 2.843 N/A GLU 81.A N GLN 77.A O no hydrogen 2.897 N/A HIS 82.A N GLU 78.A O no hydrogen 2.802 N/A GLY 83.A N LEU 79.A O no hydrogen 2.855 N/A GLU 86.A N GLU 78.A OE1 no hydrogen 3.120 N/A GLU 89.A N CYS 85.A O no hydrogen 2.951 N/A ARG 90.A N GLU 86.A O no hydrogen 2.890 N/A VAL 91.A N GLU 87.A O no hydrogen 3.045 N/A ARG 92.A N VAL 88.A O no hydrogen 2.924 N/A ARG 92.A NE GLU 89.A OE2 no hydrogen 3.034 N/A ARG 93.A N GLU 89.A O no hydrogen 3.081 N/A ARG 93.A NH2 GLU 86.A OE2 no hydrogen 3.403 N/A SER 94.A N ARG 90.A O no hydrogen 3.103 N/A SER 94.A N VAL 91.A O no hydrogen 3.000 N/A SER 94.A OG VAL 91.A O no hydrogen 2.785 N/A ARG 96.A NE GLU 33.A OE2 no hydrogen 2.639 N/A ARG 96.A NH1 ASP 115.A OD1 no hydrogen 2.946 N/A ARG 96.A NH2 PHE 32.A O no hydrogen 2.995 N/A ARG 96.A NH2 GLU 33.A OE2 no hydrogen 3.386 N/A ARG 96.A NH2 ASP 115.A OD1 no hydrogen 2.717 N/A TYR 97.A N SER 94.A OG no hydrogen 3.107 N/A TYR 97.A OH GLU 28.A OE1 no hydrogen 2.487 N/A GLN 98.A N SER 94.A O no hydrogen 3.156 N/A GLN 98.A NE2 ARG 92.A O no hydrogen 2.820 N/A THR 99.A N GLU 95.A O no hydrogen 2.958 N/A THR 99.A OG1 GLU 95.A O no hydrogen 2.714 N/A MET 100.A N ARG 96.A O no hydrogen 2.924 N/A LYS 101.A N TYR 97.A O no hydrogen 2.819 N/A LYS 101.A NZ GLU 28.A OE2 no hydrogen 2.684 N/A LEU 102.A N GLN 98.A O no hydrogen 2.987 N/A PHE 103.A N THR 99.A O no hydrogen 2.828 N/A THR 104.A N MET 100.A O no hydrogen 2.878 N/A THR 104.A OG1 MET 100.A O no hydrogen 2.668 N/A THR 104.A OG1 LYS 101.A O no hydrogen 3.350 N/A GLN 105.A N.A LYS 101.A O no hydrogen 3.160 N/A GLN 105.A N.B LYS 101.A O no hydrogen 3.165 N/A GLN 105.A NE2.B HIS 146.A NE2 no hydrogen 2.947 N/A ILE 106.A N PHE 103.A O no hydrogen 2.981 N/A VAL 109.A N ILE 106.A O no hydrogen 3.030 N/A ALA 114.A N GLY 110.A O no hydrogen 2.981 N/A ASP 115.A N VAL 111.A O no hydrogen 2.823 N/A ARG 116.A N LYS 112.A O no hydrogen 3.252 N/A ARG 116.A NH1 GLU 120.A OE2 no hydrogen 3.034 N/A TRP 117.A N THR 113.A O no hydrogen 2.994 N/A TYR 118.A N ALA 114.A O no hydrogen 2.790 N/A ARG 119.A N ASP 115.A O no hydrogen 2.939 N/A ARG 119.A NE ASP 115.A OD2 no hydrogen 2.928 N/A ARG 119.A NH2 ASP 115.A OD2 no hydrogen 3.399 N/A GLU 120.A N ARG 116.A O no hydrogen 2.931 N/A GLY 121.A N TYR 118.A O no hydrogen 3.043 N/A LEU 122.A N TRP 117.A O no hydrogen 3.024 N/A ARG 123.A N ASP 127.A OD2 no hydrogen 2.863 N/A ARG 123.A NH1 TYR 118.A O no hydrogen 2.779 N/A ARG 123.A NH1 LEU 122.A O no hydrogen 2.785 N/A THR 124.A N ASP 127.A OD2 no hydrogen 2.954 N/A ASP 127.A N THR 124.A OG1 no hydrogen 3.123 N/A LEU 128.A N LEU 125.A O no hydrogen 3.049 N/A ARG 129.A N LEU 125.A O no hydrogen 3.009 N/A ARG 129.A NH1 ASP 126.A OD1 no hydrogen 3.263 N/A ARG 129.A NH2 LEU 143.A O no hydrogen 3.088 N/A GLU 130.A N ASP 126.A O no hydrogen 2.913 N/A GLN 131.A N LEU 128.A O no hydrogen 3.330 N/A LYS 134.A N GLN 131.A O no hydrogen 3.441 N/A LEU 135.A N PRO 132.A O no hydrogen 3.401 N/A THR 136.A N GLN 139.A OE1 no hydrogen 3.075 N/A GLN 139.A N THR 136.A OG1 no hydrogen 2.907 N/A GLN 139.A NE2 GLY 108.A O no hydrogen 2.803 N/A LYS 140.A N THR 136.A O no hydrogen 2.766 N/A ALA 141.A N GLN 137.A O no hydrogen 2.939 N/A GLY 142.A N GLN 138.A O no hydrogen 2.803 N/A LEU 143.A N GLN 139.A O no hydrogen 2.835 N/A GLN 144.A N LYS 140.A O no hydrogen 2.965 N/A HIS 145.A N ALA 141.A O no hydrogen 2.984 N/A HIS 146.A N LEU 143.A O no hydrogen 3.247 N/A LEU 149.A N HIS 145.A O no hydrogen 2.974 N/A SER 150.A N GLN 147.A O no hydrogen 3.271 N/A SER 150.A OG GLN 147.A O no hydrogen 2.828 N/A THR 151.A N ASP 148.A O no hydrogen 2.957 N/A THR 151.A OG1 GLN 147.A O no hydrogen 3.300 N/A VAL 153.A N GLY 191.A O no hydrogen 2.765 N/A LEU 154.A N ASP 157.A OD2 no hydrogen 2.988 N/A ARG 155.A NH2.A PHE 184.A O no hydrogen 2.713 N/A ARG 155.A NH2.B ASP 159.A OD2 no hydrogen 3.380 N/A VAL 158.A N LEU 154.A O no hydrogen 3.191 N/A VAL 158.A N ARG 155.A O.A no hydrogen 2.939 N/A VAL 158.A N ARG 155.A O.B no hydrogen 2.877 N/A ASP 159.A N ARG 155.A O.A no hydrogen 3.270 N/A ASP 159.A N ARG 155.A O.B no hydrogen 3.256 N/A LEU 161.A N ASP 157.A O no hydrogen 3.128 N/A GLN 162.A N VAL 158.A O no hydrogen 2.850 N/A GLN 162.A NE2 GLU 166.A OE2 no hydrogen 2.967 N/A GLN 163.A N ASP 159.A O no hydrogen 3.146 N/A VAL 164.A N ALA 160.A O no hydrogen 3.273 N/A VAL 165.A N LEU 161.A O no hydrogen 2.923 N/A GLU 166.A N GLN 162.A O no hydrogen 2.835 N/A GLU 167.A N GLN 163.A O no hydrogen 2.998 N/A ALA 168.A N VAL 164.A O no hydrogen 3.154 N/A VAL 169.A N VAL 165.A O no hydrogen 2.835 N/A GLY 170.A N GLU 166.A O no hydrogen 2.709 N/A GLN 171.A N GLU 167.A O no hydrogen 3.172 N/A ALA 172.A N ALA 168.A O no hydrogen 2.901 N/A LEU 173.A N VAL 169.A O no hydrogen 2.871 N/A ALA 176.A N LEU 173.A O no hydrogen 3.009 N/A THR 177.A N THR 199.A O no hydrogen 2.848 N/A THR 179.A N LEU 197.A O no hydrogen 2.764 N/A THR 181.A N ASP 195.A O no hydrogen 2.815 N/A THR 181.A OG1.A ASP 195.A O no hydrogen 3.149 N/A THR 181.A OG1.B THR 266.A OG1 no hydrogen 2.722 N/A GLY 182.A N THR 181.A OG1.B no hydrogen 2.707 N/A GLY 182.A N TRP 265.A O.A no hydrogen 2.956 N/A GLY 182.A N TRP 265.A O.B no hydrogen 2.883 N/A ARG 185.A N GLY 182.A O no hydrogen 3.065 N/A ARG 185.A NH1 THR 266.A OG1 no hydrogen 2.904 N/A ARG 185.A NH1 GLU 306.A OE1 no hydrogen 3.302 N/A ARG 185.A NH1 GLU 306.A OE2 no hydrogen 2.943 N/A ARG 185.A NH2 GLU 306.A OE1 no hydrogen 2.887 N/A ARG 186.A N GLY 183.A O no hydrogen 2.958 N/A ARG 186.A NE ASN 324.A OD1 no hydrogen 2.816 N/A ARG 186.A NH1 THR 266.A O no hydrogen 2.836 N/A GLY 187.A N PHE 184.A O no hydrogen 3.064 N/A LYS 188.A N GLY 183.A O no hydrogen 3.199 N/A GLY 191.A N VAL 153.A O no hydrogen 2.978 N/A VAL 194.A N ARG 247.A O no hydrogen 3.012 N/A PHE 196.A N ASP 249.A O no hydrogen 2.889 N/A LEU 197.A N THR 179.A O no hydrogen 2.804 N/A ILE 198.A N VAL 251.A O no hydrogen 2.678 N/A THR 199.A N THR 177.A O no hydrogen 3.264 N/A THR 199.A OG1 ALA 253.A O no hydrogen 2.669 N/A HIS 200.A NE2 PRO 174.A O no hydrogen 2.962 N/A LYS 202.A N HIS 200.A ND1 no hydrogen 3.066 N/A GLY 204.A N GLU 206.A OE1 no hydrogen 2.792 N/A GLN 205.A N LYS 202.A O no hydrogen 3.006 N/A GLU 206.A N GLU 206.A OE1 no hydrogen 2.735 N/A ALA 207.A N GLY 204.A O no hydrogen 3.221 N/A LEU 209.A N GLU 206.A O no hydrogen 3.087 N/A ARG 212.A NE ALA 172.A O no hydrogen 2.990 N/A ARG 212.A NH2 ALA 172.A O no hydrogen 2.782 N/A VAL 213.A N LEU 209.A O no hydrogen 2.953 N/A MET 214.A N LEU 210.A O no hydrogen 2.779 N/A CYS 215.A N PRO 211.A O no hydrogen 2.841 N/A CYS 215.A SG.B PRO 211.A O no hydrogen 3.400 N/A ARG 216.A N ARG 212.A O no hydrogen 3.213 N/A ARG 216.A NH1 ARG 212.A O no hydrogen 3.189 N/A LEU 217.A N VAL 213.A O no hydrogen 2.919 N/A GLN 218.A N MET 214.A O no hydrogen 2.948 N/A ASP 219.A N CYS 215.A O no hydrogen 2.999 N/A GLN 220.A N ARG 216.A O no hydrogen 3.277 N/A GLN 220.A N LEU 217.A O no hydrogen 3.081 N/A GLY 221.A N GLN 218.A O no hydrogen 2.918 N/A LEU 222.A N LEU 217.A O no hydrogen 3.351 N/A LEU 224.A N ILE 234.A O no hydrogen 2.821 N/A TYR 225.A N ILE 234.A O no hydrogen 3.306 N/A SER 231.A N LEU 250.A O no hydrogen 2.823 N/A CYS 233.A N VAL 248.A O no hydrogen 2.876 N/A CYS 233.A SG SER 231.A OG no hydrogen 2.579 N/A ILE 234.A N TYR 225.A O no hydrogen 2.811 N/A PHE 235.A N VAL 246.A O no hydrogen 2.689 N/A ARG 236.A N LEU 222.A O no hydrogen 2.767 N/A LEU 237.A N LYS 244.A O no hydrogen 2.897 N/A GLN 239.A N SER 242.A O no hydrogen 2.907 N/A SER 242.A N GLN 239.A O no hydrogen 2.975 N/A LYS 244.A N LEU 237.A O no hydrogen 2.863 N/A LYS 244.A NZ ASP 157.A OD2 no hydrogen 2.850 N/A ALA 245.A N ASP 148.A OD2 no hydrogen 2.869 N/A VAL 246.A N PHE 235.A O no hydrogen 2.904 N/A ARG 247.A NH1 CYS 233.A O no hydrogen 2.951 N/A ARG 247.A NH1 VAL 248.A O no hydrogen 3.367 N/A ARG 247.A NH1 ASP 249.A OD1 no hydrogen 2.882 N/A ARG 247.A NH2 ASP 249.A OD1 no hydrogen 2.801 N/A ARG 247.A NH2 ASP 249.A OD2 no hydrogen 3.322 N/A VAL 248.A N CYS 233.A O no hydrogen 3.015 N/A ASP 249.A N VAL 194.A O no hydrogen 2.875 N/A LEU 250.A N SER 231.A O no hydrogen 2.934 N/A VAL 251.A N PHE 196.A O no hydrogen 3.068 N/A VAL 252.A N GLU 229.A O no hydrogen 2.947 N/A ALA 253.A N ILE 198.A O no hydrogen 3.014 N/A SER 256.A N GLU 203.A OE1 no hydrogen 2.911 N/A SER 256.A OG GLU 203.A OE1 no hydrogen 3.382 N/A SER 256.A OG GLU 203.A OE2 no hydrogen 2.730 N/A GLN 257.A N PRO 254.A O no hydrogen 2.808 N/A PHE 258.A N VAL 255.A O no hydrogen 3.089 N/A ALA 261.A N GLN 257.A O no hydrogen 3.069 N/A LEU 262.A N PHE 258.A O no hydrogen 2.769 N/A LEU 263.A N PRO 259.A O no hydrogen 2.938 N/A GLY 264.A N PHE 260.A O no hydrogen 2.935 N/A TRP 265.A N.A ALA 261.A O no hydrogen 2.822 N/A TRP 265.A N.B ALA 261.A O no hydrogen 2.824 N/A THR 266.A N LEU 262.A O no hydrogen 3.036 N/A THR 266.A OG1 THR 181.A OG1.B no hydrogen 2.722 N/A THR 266.A OG1 LEU 262.A O no hydrogen 2.697 N/A SER 268.A N ARG 323.A O no hydrogen 3.062 N/A SER 268.A OG ARG 323.A O no hydrogen 3.322 N/A SER 268.A OG ALA 325.A O no hydrogen 2.812 N/A PHE 271.A N SER 268.A OG no hydrogen 3.045 N/A GLN 272.A N SER 268.A O no hydrogen 2.847 N/A GLN 272.A NE2 GLY 267.A O no hydrogen 3.395 N/A ARG 273.A N LYS 269.A O no hydrogen 3.077 N/A GLU 274.A N LEU 270.A O no hydrogen 2.897 N/A LEU 275.A N PHE 271.A O no hydrogen 2.855 N/A ARG 276.A N GLN 272.A O no hydrogen 2.906 N/A ARG 277.A N ARG 273.A O no hydrogen 2.870 N/A ARG 277.A NE GLU 274.A OE2 no hydrogen 3.181 N/A ARG 277.A NH2 GLU 274.A OE1 no hydrogen 3.197 N/A ARG 277.A NH2 GLU 274.A OE2 no hydrogen 2.787 N/A PHE 278.A N GLU 274.A O no hydrogen 2.721 N/A SER 279.A N LEU 275.A O no hydrogen 2.889 N/A SER 279.A OG LEU 285.A O no hydrogen 2.760 N/A ARG 280.A N ARG 276.A O no hydrogen 2.975 N/A LYS 281.A N ARG 277.A O no hydrogen 2.827 N/A GLU 282.A N PHE 278.A O no hydrogen 2.822 N/A LYS 283.A N SER 279.A O no hydrogen 3.153 N/A GLY 284.A N ARG 280.A O no hydrogen 3.150 N/A LEU 285.A N SER 279.A O no hydrogen 2.997 N/A TRP 286.A N PHE 293.A O no hydrogen 2.821 N/A ASN 288.A N GLY 291.A O no hydrogen 3.008 N/A HIS 290.A N ASN 288.A OD1 no hydrogen 2.752 N/A HIS 290.A ND1 GLN 257.A OE1 no hydrogen 3.242 N/A GLY 291.A N ASN 288.A OD1 no hydrogen 2.944 N/A PHE 293.A N TRP 286.A O no hydrogen 2.786 N/A ASP 294.A N THR 299.A O no hydrogen 2.874 N/A GLU 296.A N ASP 294.A OD1 no hydrogen 2.821 N/A GLN 297.A N ASP 294.A OD1 no hydrogen 3.276 N/A THR 299.A N ASP 294.A O no hydrogen 3.259 N/A PHE 301.A N.A LEU 292.A O no hydrogen 2.924 N/A PHE 301.A N.B LEU 292.A O no hydrogen 2.932 N/A ALA 304.A N ASP 308.A OD2 no hydrogen 2.983 N/A ASP 308.A N SER 305.A OG no hydrogen 3.014 N/A ILE 309.A N SER 305.A O no hydrogen 3.367 N/A PHE 310.A N GLU 306.A O no hydrogen 3.022 N/A ARG 311.A N GLU 307.A O no hydrogen 2.997 N/A ARG 311.A NH1 GLU 307.A OE1 no hydrogen 3.508 N/A ARG 311.A NH2 ASP 308.A OD1 no hydrogen 2.785 N/A HIS 312.A N.A ASP 308.A O no hydrogen 2.858 N/A HIS 312.A N.B ASP 308.A O no hydrogen 2.905 N/A HIS 312.A NE2.A GLN 302.A O no hydrogen 3.232 N/A LEU 313.A N ILE 309.A O no hydrogen 3.140 N/A GLY 314.A N ARG 311.A O no hydrogen 3.025 N/A LEU 315.A N PHE 310.A O no hydrogen 3.003 N/A GLU 321.A N GLU 321.A OE1.A no hydrogen 2.924 N/A GLU 321.A N GLU 321.A OE1.B no hydrogen 2.687 N/A GLN 322.A N PRO 319.A O no hydrogen 2.820 N/A ARG 323.A N PRO 320.A O no hydrogen 2.979 N/A ARG 323.A NE LEU 318.A O no hydrogen 2.866 N/A ARG 323.A NH1 GLU 306.A OE2 no hydrogen 2.766 N/A ARG 323.A NH2 GLU 306.A OE1 no hydrogen 2.968 N/A ARG 323.A NH2 LEU 318.A O no hydrogen 2.942 N/A ASN 324.A N THR 10.A O no hydrogen 2.990 N/A ASN 324.A ND2 ARG 186.A O no hydrogen 3.379 N/A ASN 324.A ND2 GLU 321.A O no hydrogen 3.086 N/A