Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 5twz_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): TYR 4.A N SER 1.A O no hydrogen 3.281 N/A ASP 5.A N LYS 2.A O no hydrogen 3.211 N/A LEU 7.A N TYR 4.A O no hydrogen 3.098 N/A LEU 8.A N TYR 4.A O no hydrogen 2.823 N/A TYR 10.A N LEU 7.A O no hydrogen 2.718 N/A TYR 11.A N LEU 7.A O no hydrogen 3.116 N/A TYR 11.A OH HIS 71.A ND1 no hydrogen 2.614 N/A GLU 12.A N CYS 26.A O no hydrogen 3.040 N/A HIS 14.A N LEU 24.A O no hydrogen 2.602 N/A HIS 14.A ND1 LEU 13.A O no hydrogen 2.673 N/A ILE 17.A N VAL 22.A O no hydrogen 2.885 N/A LYS 21.A N ILE 38.A O no hydrogen 3.101 N/A LYS 23.A N ILE 36.A O no hydrogen 2.983 N/A LEU 24.A N GLU 15.A O no hydrogen 2.956 N/A ALA 25.A N VAL 34.A O no hydrogen 3.143 N/A CYS 26.A N GLU 12.A O no hydrogen 2.909 N/A CYS 26.A SG HIS 27.A O no hydrogen 3.756 N/A HIS 27.A N GLU 32.A O no hydrogen 3.057 N/A HIS 27.A ND1 THR 30.A OG1 no hydrogen 3.270 N/A HIS 27.A NE2 HIS 292.A NE2 no hydrogen 2.836 N/A ILE 28.A N TYR 10.A O no hydrogen 3.342 N/A THR 30.A OG1 HIS 27.A ND1 no hydrogen 3.270 N/A GLY 31.A N HIS 27.A O no hydrogen 2.820 N/A GLU 32.A N THR 30.A OG1 no hydrogen 3.101 N/A VAL 34.A N ALA 25.A O no hydrogen 2.860 N/A ALA 35.A N LEU 83.A O no hydrogen 3.181 N/A ILE 36.A N LYS 23.A O no hydrogen 3.051 N/A LYS 37.A N MET 81.A O no hydrogen 2.666 N/A LYS 37.A NZ ASP 147.A OD1 no hydrogen 2.927 N/A ILE 38.A N LYS 21.A O no hydrogen 2.604 N/A MET 39.A N ILE 79.A O no hydrogen 3.037 N/A LYS 41.A NZ GLU 74.A OE2 no hydrogen 2.430 N/A LYS 41.A NZ THR 75.A O no hydrogen 3.156 N/A LYS 41.A NZ ALA 76.A O no hydrogen 3.562 N/A ASN 42.A N ASP 40.A OD1 no hydrogen 2.964 N/A LYS 52.A N LEU 48.A O no hydrogen 2.429 N/A THR 53.A N PRO 49.A O no hydrogen 2.979 N/A GLU 54.A N ARG 50.A O no hydrogen 3.162 N/A ILE 55.A N ILE 51.A O no hydrogen 2.691 N/A GLU 56.A N LYS 52.A O no hydrogen 2.883 N/A ALA 57.A N THR 53.A O no hydrogen 3.200 N/A LEU 58.A N GLU 54.A O no hydrogen 3.119 N/A LYS 59.A N ILE 55.A O no hydrogen 3.010 N/A LYS 59.A NZ GLU 56.A OE1 no hydrogen 2.951 N/A ASN 60.A N ALA 57.A O no hydrogen 2.548 N/A ASN 60.A ND2 GLU 56.A O no hydrogen 2.987 N/A LEU 61.A N LEU 58.A O no hydrogen 3.234 N/A ARG 62.A N TYR 119.A OH no hydrogen 3.154 N/A ARG 62.A NE TYR 290.A OH no hydrogen 3.500 N/A ARG 62.A NH1 PRO 258.A O no hydrogen 3.511 N/A ARG 62.A NH2 TYR 290.A OH no hydrogen 3.096 N/A HIS 63.A NE2 TRP 253.A O no hydrogen 2.841 N/A GLN 64.A N GLN 64.A OE1 no hydrogen 2.769 N/A GLN 64.A NE2 GLN 254.A O no hydrogen 3.379 N/A HIS 65.A N HIS 63.A ND1 no hydrogen 3.170 N/A HIS 65.A ND1 LEU 143.A O no hydrogen 2.833 N/A ILE 66.A N HIS 63.A O no hydrogen 3.010 N/A CYS 67.A N LEU 145.A O no hydrogen 2.912 N/A CYS 67.A SG GLU 84.A O no hydrogen 3.814 N/A GLN 68.A N GLU 84.A OE2 no hydrogen 3.167 N/A GLN 68.A NE2 LEU 61.A O no hydrogen 3.644 N/A GLN 68.A NE2 ILE 66.A O no hydrogen 3.384 N/A TYR 70.A N VAL 82.A O no hydrogen 2.739 N/A HIS 71.A ND1 TYR 11.A OH no hydrogen 2.614 N/A VAL 72.A N TYR 290.A O no hydrogen 3.008 N/A LEU 73.A N PHE 80.A O no hydrogen 2.899 N/A THR 75.A N LYS 78.A O no hydrogen 3.040 N/A THR 75.A OG1 ASP 3.A OD1 no hydrogen 3.110 N/A ALA 76.A N THR 75.A OG1 no hydrogen 2.755 N/A ILE 79.A N MET 39.A O no hydrogen 2.881 N/A PHE 80.A N LEU 73.A O no hydrogen 2.753 N/A MET 81.A N LYS 37.A O no hydrogen 2.927 N/A VAL 82.A N HIS 71.A O no hydrogen 2.905 N/A LEU 83.A N ALA 35.A O no hydrogen 2.649 N/A CYS 86.A SG GLU 84.A O no hydrogen 3.629 N/A GLY 88.A N PHE 137.A O no hydrogen 2.808 N/A LEU 91.A N LEU 135.A O no hydrogen 2.959 N/A TYR 94.A N GLU 90.A O no hydrogen 3.171 N/A TYR 94.A OH GLU 105.A OE1 no hydrogen 2.429 N/A TYR 94.A OH GLU 105.A OE2 no hydrogen 3.202 N/A ILE 95.A N LEU 91.A O no hydrogen 3.075 N/A ILE 96.A N PHE 92.A O no hydrogen 3.166 N/A SER 97.A N ASP 93.A O no hydrogen 2.947 N/A SER 97.A OG TYR 94.A O no hydrogen 2.867 N/A GLN 98.A N TYR 94.A O no hydrogen 3.231 N/A ASP 99.A N ILE 96.A O no hydrogen 3.198 N/A ARG 100.A N GLN 98.A O no hydrogen 2.606 N/A LEU 101.A N LEU 182.A O no hydrogen 3.221 N/A SER 102.A OG GLU 104.A OE1 no hydrogen 2.368 N/A GLU 104.A N SER 102.A OG no hydrogen 2.791 N/A GLU 104.A N GLU 104.A OE1 no hydrogen 2.724 N/A GLU 105.A N SER 102.A OG no hydrogen 3.249 N/A THR 106.A N SER 102.A O no hydrogen 3.113 N/A THR 106.A OG1 SER 102.A O no hydrogen 2.775 N/A THR 106.A OG1 GLU 103.A O no hydrogen 2.761 N/A ARG 107.A N GLU 103.A O no hydrogen 3.057 N/A ARG 107.A NE TRP 242.A O no hydrogen 2.876 N/A ARG 107.A NH1 GLU 103.A OE1 no hydrogen 3.285 N/A ARG 107.A NH1 ASP 246.A OD2 no hydrogen 2.302 N/A ARG 107.A NH2 GLU 103.A OE1 no hydrogen 2.539 N/A VAL 108.A N GLU 104.A O no hydrogen 3.117 N/A VAL 109.A N GLU 105.A O no hydrogen 2.906 N/A PHE 110.A N THR 106.A O no hydrogen 2.437 N/A ARG 111.A N ARG 107.A O no hydrogen 2.975 N/A ARG 111.A NE ILE 243.A O no hydrogen 3.085 N/A GLN 112.A N VAL 109.A O no hydrogen 3.182 N/A ILE 113.A N VAL 109.A O no hydrogen 3.364 N/A VAL 114.A N PHE 110.A O no hydrogen 2.956 N/A SER 115.A N ARG 111.A O no hydrogen 3.054 N/A SER 115.A OG GLU 252.A O no hydrogen 2.901 N/A ALA 116.A N GLN 112.A O no hydrogen 2.985 N/A VAL 117.A N ILE 113.A O no hydrogen 2.815 N/A ALA 118.A N VAL 114.A O no hydrogen 2.779 N/A TYR 119.A N SER 115.A O no hydrogen 3.131 N/A VAL 120.A N ALA 116.A O no hydrogen 3.071 N/A HIS 121.A N VAL 117.A O no hydrogen 3.135 N/A HIS 121.A NE2 ASP 171.A OD2 no hydrogen 2.954 N/A SER 122.A N ALA 118.A O no hydrogen 3.111 N/A SER 122.A OG TYR 119.A O no hydrogen 2.623 N/A GLN 123.A N TYR 119.A O no hydrogen 3.386 N/A GLN 123.A NE2 SER 122.A OG no hydrogen 3.359 N/A GLY 124.A N HIS 121.A O no hydrogen 2.801 N/A TYR 125.A N VAL 120.A O no hydrogen 3.075 N/A HIS 127.A N ASP 171.A OD2 no hydrogen 2.903 N/A HIS 127.A NE2 ILE 146.A O no hydrogen 2.840 N/A ARG 128.A N ASP 171.A OD1 no hydrogen 2.754 N/A ASP 129.A N HIS 127.A ND1 no hydrogen 3.037 N/A GLU 133.A N GLU 133.A OE2 no hydrogen 3.043 N/A ASN 134.A N LYS 131.A O no hydrogen 2.909 N/A ASN 134.A ND2 ASP 129.A O no hydrogen 2.624 N/A LEU 135.A N PRO 132.A O no hydrogen 3.359 N/A LEU 136.A N LYS 144.A O no hydrogen 2.800 N/A PHE 137.A N GLY 89.A O no hydrogen 2.877 N/A ASP 138.A N LYS 142.A O no hydrogen 2.999 N/A HIS 141.A N ASP 138.A O no hydrogen 3.078 N/A LYS 142.A N ASP 138.A OD1 no hydrogen 2.729 N/A LEU 143.A N GLN 112.A OE1 no hydrogen 2.669 N/A LYS 144.A N LEU 136.A O no hydrogen 2.688 N/A LYS 144.A NZ GLN 64.A O no hydrogen 2.663 N/A LYS 144.A NZ GLU 84.A OE1 no hydrogen 3.157 N/A LEU 145.A N HIS 65.A O no hydrogen 2.875 N/A ILE 146.A N ASN 134.A O no hydrogen 3.098 N/A ALA 155.A N LEU 152.A O no hydrogen 3.175 N/A GLU 158.A N GLU 158.A OE2 no hydrogen 2.640 N/A ILE 160.A N ALA 156.A O no hydrogen 2.920 N/A GLN 161.A N PRO 157.A O no hydrogen 2.895 N/A GLY 162.A N LEU 159.A O no hydrogen 3.380 N/A LYS 163.A N GLU 158.A O no hydrogen 3.024 N/A ALA 170.A N LEU 166.A O no hydrogen 3.199 N/A ASP 171.A N GLY 167.A O no hydrogen 3.171 N/A VAL 172.A N SER 168.A O no hydrogen 2.947 N/A TRP 173.A N GLU 169.A O no hydrogen 2.991 N/A SER 174.A N ALA 170.A O no hydrogen 2.943 N/A SER 174.A OG TYR 154.A O no hydrogen 2.949 N/A SER 174.A OG ALA 170.A O no hydrogen 2.971 N/A MET 175.A N ASP 171.A O no hydrogen 2.723 N/A GLY 176.A N VAL 172.A O no hydrogen 2.973 N/A ILE 177.A N TRP 173.A O no hydrogen 2.866 N/A LEU 178.A N SER 174.A O no hydrogen 2.864 N/A LEU 179.A N MET 175.A O no hydrogen 2.692 N/A TYR 180.A N GLY 176.A O no hydrogen 3.142 N/A TYR 180.A OH ASP 207.A O no hydrogen 2.814 N/A VAL 181.A N ILE 177.A O no hydrogen 3.171 N/A LEU 182.A N LEU 178.A O no hydrogen 3.001 N/A MET 183.A N LEU 179.A O no hydrogen 3.331 N/A CYS 184.A N TYR 180.A O no hydrogen 2.958 N/A CYS 184.A SG TYR 180.A O no hydrogen 3.349 N/A GLY 185.A N VAL 181.A O no hydrogen 2.852 N/A ASN 193.A N ASP 191.A OD2 no hydrogen 2.821 N/A LEU 197.A N ASN 193.A O no hydrogen 3.240 N/A TYR 198.A N VAL 194.A O no hydrogen 2.417 N/A LYS 199.A N MET 195.A O no hydrogen 2.991 N/A LYS 200.A N ALA 196.A O no hydrogen 2.812 N/A ILE 201.A N LEU 197.A O no hydrogen 3.165 N/A ARG 203.A N LYS 199.A O no hydrogen 3.076 N/A GLY 204.A N LYS 200.A O no hydrogen 3.206 N/A TRP 211.A NE1 MET 183.A O no hydrogen 2.922 N/A SER 213.A OG GLU 103.A OE2 no hydrogen 2.249 N/A SER 215.A OG GLN 245.A OE1 no hydrogen 2.707 N/A SER 216.A N SER 213.A O no hydrogen 2.871 N/A SER 216.A OG GLU 103.A OE2 no hydrogen 3.557 N/A ILE 217.A N SER 213.A O no hydrogen 2.927 N/A LEU 220.A N SER 216.A O no hydrogen 3.381 N/A GLN 221.A N ILE 217.A O no hydrogen 3.311 N/A GLN 222.A N LEU 218.A O no hydrogen 2.996 N/A MET 223.A N LEU 219.A O no hydrogen 2.828 N/A LEU 224.A N LEU 220.A O no hydrogen 2.841 N/A LYS 230.A N ASP 227.A O no hydrogen 3.303 N/A ARG 231.A N PRO 228.A O no hydrogen 2.974 N/A ARG 231.A NE GLU 169.A O no hydrogen 2.972 N/A ARG 231.A NH1 GLN 225.A O no hydrogen 2.669 N/A ARG 231.A NH2 GLU 158.A OE2 no hydrogen 2.980 N/A ARG 231.A NH2 GLU 169.A O no hydrogen 3.333 N/A ILE 232.A N GLN 222.A O no hydrogen 3.127 N/A ASN 236.A N SER 233.A OG no hydrogen 3.379 N/A LEU 237.A N SER 233.A O no hydrogen 2.932 N/A LEU 238.A N MET 234.A O no hydrogen 2.897 N/A HIS 240.A N LEU 237.A O no hydrogen 3.288 N/A HIS 240.A NE2 GLN 222.A OE1 no hydrogen 2.780 N/A TRP 242.A N HIS 240.A ND1 no hydrogen 2.978 N/A MET 244.A N HIS 240.A O no hydrogen 2.868 N/A GLN 245.A N TRP 242.A O no hydrogen 3.246 N/A TYR 247.A N GLN 245.A O no hydrogen 2.557 N/A VAL 251.A N LEU 238.A O no hydrogen 3.000 N/A SER 255.A OG ARG 62.A O no hydrogen 2.513 N/A LYS 256.A N GLN 64.A OE1 no hydrogen 3.189 N/A ASN 257.A N SER 255.A OG no hydrogen 3.068 N/A ASP 263.A N TYR 297.A OH no hydrogen 2.785 N/A CYS 266.A N ASP 263.A OD1 no hydrogen 2.958 N/A CYS 266.A SG ASP 263.A OD1 no hydrogen 3.329 N/A VAL 267.A N ASP 263.A O no hydrogen 3.007 N/A THR 268.A N ASP 264.A O no hydrogen 2.820 N/A THR 268.A OG1 ASP 265.A O no hydrogen 3.270 N/A GLU 269.A N ASP 265.A O no hydrogen 3.164 N/A LEU 270.A N CYS 266.A O no hydrogen 3.027 N/A SER 271.A N VAL 267.A O no hydrogen 2.899 N/A SER 271.A OG VAL 267.A O no hydrogen 2.769 N/A VAL 272.A N THR 268.A O no hydrogen 3.098 N/A HIS 273.A N GLU 269.A O no hydrogen 3.345 N/A HIS 274.A N LEU 270.A O no hydrogen 3.065 N/A HIS 274.A ND1 LEU 270.A O no hydrogen 3.182 N/A ASN 276.A N SER 271.A O no hydrogen 3.041 N/A GLN 279.A NE2 GLN 279.A O no hydrogen 3.175 N/A GLN 279.A NE2 ASP 283.A OD2 no hydrogen 2.475 N/A THR 280.A OG1 ASN 277.A OD1 no hydrogen 2.550 N/A MET 281.A N ASN 277.A O no hydrogen 3.368 N/A GLU 282.A N ARG 278.A O no hydrogen 2.936 N/A ASP 283.A N GLN 279.A O no hydrogen 2.876 N/A LEU 284.A N THR 280.A O no hydrogen 3.186 N/A ILE 285.A N MET 281.A O no hydrogen 2.736 N/A SER 286.A N GLU 282.A O no hydrogen 2.750 N/A SER 286.A OG GLU 282.A O no hydrogen 2.375 N/A TRP 288.A N ILE 285.A O no hydrogen 3.065 N/A TYR 290.A N THR 294.A OG1 no hydrogen 3.057 N/A TYR 290.A OH LYS 59.A O no hydrogen 3.101 N/A HIS 292.A NE2 HIS 27.A NE2 no hydrogen 2.836 N/A THR 294.A N ASP 291.A OD1 no hydrogen 3.487 N/A THR 294.A OG1 ASP 291.A OD1 no hydrogen 3.535 N/A ALA 295.A N ASP 291.A O no hydrogen 3.328 N/A THR 296.A N HIS 292.A O no hydrogen 2.915 N/A THR 296.A OG1 HIS 292.A O no hydrogen 2.685 N/A TYR 297.A N LEU 293.A O no hydrogen 2.812 N/A LEU 298.A N THR 294.A O no hydrogen 2.888 N/A LEU 299.A N ALA 295.A O no hydrogen 2.870 N/A LEU 300.A N THR 296.A O no hydrogen 2.760 N/A LEU 301.A N TYR 297.A O no hydrogen 2.760 N/A ALA 302.A N LEU 298.A O no hydrogen 2.951 N/A LYS 303.A N LEU 299.A O no hydrogen 2.921 N/A LYS 303.A NZ PRO 309.A O no hydrogen 2.674 N/A LYS 304.A N LEU 300.A O no hydrogen 3.214 N/A LYS 304.A NZ ASP 263.A OD1 no hydrogen 3.273 N/A LYS 304.A NZ ASP 263.A OD2 no hydrogen 2.949 N/A LYS 304.A NZ ASP 265.A OD1 no hydrogen 2.914 N/A ALA 305.A N LEU 301.A O no hydrogen 3.192 N/A ARG 306.A N ALA 302.A O no hydrogen 3.129 N/A ARG 306.A NH1 GLU 32.A OE1 no hydrogen 2.859 N/A GLY 307.A N LYS 303.A O no hydrogen 3.388 N/A LYS 308.A N LYS 303.A O no hydrogen 3.239 N/A LYS 308.A NZ GLU 32.A OE2 no hydrogen 2.327 N/A LEU 312.A N GLU 269.A OE1 no hydrogen 2.981 N/A ARG 313.A N LEU 29.A O no hydrogen 2.765 N/A