Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6c49_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASN 2.A ND2 GLU 25.A OE2.A no hydrogen 2.789 N/A ILE 4.A N PHE 21.A O no hydrogen 2.893 N/A GLN 5.A N ASP 125.A OD1 no hydrogen 3.072 N/A GLN 5.A NE2 ASP 125.A OD2 no hydrogen 2.904 N/A GLN 5.A NE2 ALA 337.A O no hydrogen 3.405 N/A ALA 6.A N TYR 19.A O no hydrogen 2.746 N/A TYR 7.A N PHE 123.A O no hydrogen 2.931 N/A ALA 8.A N VAL 17.A O no hydrogen 2.945 N/A ALA 9.A N VAL 59.A O no hydrogen 3.015 N/A GLU 14.A N GLN 11.A O no hydrogen 3.450 N/A LEU 16.A N ASN 315.A OD1 no hydrogen 2.844 N/A VAL 17.A N ALA 8.A O no hydrogen 2.825 N/A TYR 19.A N ALA 6.A O no hydrogen 2.906 N/A PHE 21.A N ILE 4.A O no hydrogen 2.985 N/A ALA 23.A N ASN 2.A O no hydrogen 2.809 N/A GLY 24.A N ASP 22.A OD1 no hydrogen 2.964 N/A GLN 27.A N GLN 30.A OE1 no hydrogen 2.895 N/A GLN 27.A NE2 GLU 25.A O no hydrogen 2.902 N/A HIS 29.A NE2 GLU 92.A OE1 no hydrogen 2.856 N/A GLN 30.A N GLN 27.A O no hydrogen 2.993 N/A GLN 30.A NE2 GLU 92.A OE2 no hydrogen 2.888 N/A VAL 31.A N ALA 129.A O no hydrogen 2.818 N/A GLU 32.A N ALA 71.A O no hydrogen 2.964 N/A VAL 33.A N VAL 127.A O no hydrogen 2.819 N/A LYS 34.A N ARG 68.A O no hydrogen 2.801 N/A VAL 35.A N ASP 125.A O no hydrogen 2.944 N/A GLU 36.A N ILE 66.A O no hydrogen 2.809 N/A TYR 37.A N ILE 66.A O no hydrogen 3.004 N/A CYS 38.A N LEU 332.A O no hydrogen 2.876 N/A CYS 38.A SG GLY 39.A O no hydrogen 3.479 N/A GLY 39.A N GLU 64.A O no hydrogen 2.898 N/A LEU 40.A N ILE 330.A O no hydrogen 2.901 N/A CYS 41.A N ASP 44.A OD2 no hydrogen 3.135 N/A CYS 41.A SG HIS 63.A NE2 no hydrogen 3.526 N/A CYS 41.A SG GLU 64.A OE2 no hydrogen 3.472 N/A ASP 44.A N CYS 41.A O no hydrogen 3.039 N/A SER 46.A N HIS 42.A O no hydrogen 2.871 N/A SER 46.A OG HIS 42.A O no hydrogen 3.309 N/A SER 46.A OG GLU 51.A OE1 no hydrogen 2.974 N/A VAL 47.A N SER 43.A O no hydrogen 3.093 N/A LEU 48.A N ASP 44.A O no hydrogen 2.788 N/A ASN 49.A N ILE 45.A O no hydrogen 2.868 N/A ASN 50.A N VAL 47.A O no hydrogen 2.932 N/A GLU 51.A N SER 46.A O no hydrogen 2.876 N/A HIS 53.A N ASN 50.A O no hydrogen 3.202 N/A THR 55.A N ASN 50.A OD1 no hydrogen 3.081 N/A THR 55.A OG1 VAL 47.A O no hydrogen 2.585 N/A THR 55.A OG1 ASN 50.A OD1 no hydrogen 3.467 N/A TYR 57.A OH LEU 48.A O no hydrogen 2.650 N/A VAL 59.A N ALA 9.A O no hydrogen 3.064 N/A GLY 62.A N ASP 44.A OD1 no hydrogen 2.907 N/A HIS 63.A ND1 ASP 44.A OD1 no hydrogen 2.802 N/A ILE 65.A N ILE 87.A O no hydrogen 2.906 N/A ILE 66.A N TYR 37.A O no hydrogen 2.891 N/A GLY 67.A N VAL 85.A O no hydrogen 3.052 N/A ARG 68.A N LYS 34.A O no hydrogen 3.109 N/A ARG 68.A NH1 GLY 82.A O no hydrogen 2.867 N/A ILE 69.A N GLN 83.A O no hydrogen 2.900 N/A VAL 70.A N GLU 32.A O no hydrogen 2.784 N/A ALA 71.A N GLU 32.A O no hydrogen 3.302 N/A GLY 73.A N GLN 30.A O no hydrogen 2.812 N/A GLU 75.A N PRO 28.A O no hydrogen 2.896 N/A ALA 76.A N GLY 73.A O no hydrogen 3.042 N/A GLN 80.A N GLN 83.A OE1 no hydrogen 3.048 N/A GLY 82.A N ILE 69.A O no hydrogen 2.791 N/A GLN 83.A N GLN 80.A O no hydrogen 3.167 N/A ARG 84.A NE GLU 36.A OE1 no hydrogen 2.830 N/A ARG 84.A NH2 GLU 36.A OE2 no hydrogen 2.927 N/A VAL 85.A N GLY 67.A O no hydrogen 2.812 N/A GLY 86.A N ILE 135.A O no hydrogen 2.754 N/A ILE 87.A N ILE 65.A O no hydrogen 2.936 N/A ALA 91.A N ILE 113.A O no hydrogen 2.891 N/A GLU 92.A N ILE 113.A O no hydrogen 3.039 N/A CYS 97.A SG GLU 99.A OE1 no hydrogen 3.735 N/A CYS 100.A SG SER 93.A OG no hydrogen 3.623 N/A ILE 101.A N CYS 97.A O no hydrogen 2.869 N/A GLY 102.A N ASP 98.A O no hydrogen 3.069 N/A GLY 103.A N CYS 100.A O no hydrogen 3.085 N/A GLN 104.A N GLU 99.A O no hydrogen 2.770 N/A GLN 105.A N GLN 105.A OE1 no hydrogen 2.722 N/A VAL 106.A N SER 286.A OG no hydrogen 2.968 N/A LEU 107.A N GLN 104.A O no hydrogen 2.845 N/A CYS 108.A N GLN 105.A O no hydrogen 3.146 N/A CYS 108.A SG GLU 111.A O no hydrogen 3.761 N/A THR 109.A OG1 GLU 99.A OE1 no hydrogen 2.788 N/A ASN 112.A ND2 GLY 110.A O no hydrogen 3.061 N/A ILE 113.A N GLU 92.A O no hydrogen 2.854 N/A THR 115.A N TRP 89.A O no hydrogen 2.778 N/A THR 115.A OG1 GLY 88.A O no hydrogen 2.683 N/A VAL 117.A N ALA 114.A O no hydrogen 3.102 N/A HIS 119.A ND1 THR 115.A O no hydrogen 2.835 N/A GLY 121.A N VAL 60.A O no hydrogen 2.900 N/A GLY 122.A N GLY 62.A O no hydrogen 2.742 N/A PHE 123.A N ALA 61.A O no hydrogen 2.979 N/A ASP 125.A N GLN 5.A O no hydrogen 2.880 N/A LYS 126.A NZ THR 3.A O no hydrogen 3.446 N/A VAL 127.A N VAL 33.A O no hydrogen 2.934 N/A ARG 128.A NE GLU 32.A OE2 no hydrogen 2.777 N/A ARG 128.A NH1 GLY 24.A O no hydrogen 2.776 N/A ARG 128.A NH2 ASN 2.A OD1 no hydrogen 3.027 N/A ARG 128.A NH2 GLY 24.A O no hydrogen 3.096 N/A ARG 128.A NH2 GLU 32.A OE2 no hydrogen 3.246 N/A ALA 129.A N VAL 31.A O no hydrogen 3.155 N/A GLY 130.A N ALA 91.A O no hydrogen 2.737 N/A TRP 131.A N HIS 29.A O no hydrogen 2.994 N/A GLN 132.A N GLN 132.A OE1.A no hydrogen 2.866 N/A GLN 132.A NE2.A SER 93.A O no hydrogen 3.503 N/A GLN 132.A NE2.A SER 93.A OG no hydrogen 3.160 N/A TRP 133.A N GLY 130.A O no hydrogen 2.956 N/A TRP 133.A NE1 SER 93.A OG no hydrogen 3.122 N/A ALA 134.A N TRP 131.A O no hydrogen 3.307 N/A ILE 135.A N GLY 86.A O no hydrogen 2.782 N/A LEU 137.A N ARG 84.A O no hydrogen 3.084 N/A LEU 141.A N PRO 138.A O no hydrogen 3.191 N/A GLU 144.A N ASP 142.A OD1 no hydrogen 3.056 N/A LEU 149.A N ALA 146.A O no hydrogen 2.916 N/A LEU 150.A N GLY 147.A O no hydrogen 2.966 N/A CYS 151.A N PRO 148.A O no hydrogen 3.221 N/A CYS 151.A SG HIS 63.A NE2 no hydrogen 3.712 N/A GLY 153.A N PRO 148.A O no hydrogen 3.170 N/A ILE 154.A N LEU 149.A O no hydrogen 2.921 N/A THR 155.A N CYS 151.A O no hydrogen 3.132 N/A THR 155.A OG1.A CYS 151.A O no hydrogen 3.208 N/A THR 155.A OG1.A GLY 152.A O no hydrogen 3.012 N/A THR 155.A OG1.B CYS 151.A O no hydrogen 2.421 N/A VAL 156.A N GLY 152.A O no hydrogen 3.373 N/A VAL 156.A N GLY 153.A O no hydrogen 3.178 N/A PHE 157.A N GLY 153.A O no hydrogen 2.845 N/A ASP 158.A N ILE 154.A O no hydrogen 2.900 N/A LEU 160.A N VAL 156.A O no hydrogen 3.427 N/A LEU 161.A N PHE 157.A O no hydrogen 3.070 N/A LYS 162.A N ASP 158.A O no hydrogen 2.803 N/A HIS 163.A N PRO 159.A O no hydrogen 2.902 N/A HIS 163.A NE2 HIS 256.A ND1 no hydrogen 3.176 N/A LYS 164.A N LEU 161.A O no hydrogen 3.143 N/A LYS 164.A NZ LEU 161.A O no hydrogen 2.880 N/A ILE 165.A N LEU 160.A O no hydrogen 3.013 N/A GLN 166.A N HIS 169.A ND1 no hydrogen 2.868 N/A HIS 169.A N GLN 166.A O no hydrogen 2.968 N/A HIS 170.A N ASP 232.A OD2 no hydrogen 2.929 N/A HIS 170.A NE2 THR 195.A OG1 no hydrogen 2.720 N/A VAL 171.A N GLU 193.A O no hydrogen 2.902 N/A GLY 172.A N LEU 233.A O no hydrogen 2.857 N/A VAL 173.A N THR 195.A O no hydrogen 2.836 N/A ILE 174.A N LEU 235.A O no hydrogen 2.794 N/A GLY 175.A N PHE 197.A O no hydrogen 3.003 N/A HIS 181.A N GLY 177.A O no hydrogen 2.972 N/A ILE 182.A N GLY 178.A O no hydrogen 3.106 N/A ALA 183.A N LEU 179.A O no hydrogen 3.015 N/A ILE 184.A N GLY 180.A O no hydrogen 2.957 N/A LYS 185.A N HIS 181.A O no hydrogen 3.226 N/A LYS 185.A NZ ALA 303.A O no hydrogen 2.809 N/A LEU 186.A N ILE 182.A O no hydrogen 3.062 N/A LEU 187.A N ALA 183.A O no hydrogen 2.877 N/A LYS 188.A N ILE 184.A O no hydrogen 2.822 N/A ALA 189.A N LYS 185.A O no hydrogen 3.145 N/A TRP 190.A N LEU 186.A O no hydrogen 2.982 N/A TRP 190.A NE1 ILE 165.A O no hydrogen 2.896 N/A GLY 191.A N LYS 188.A O no hydrogen 3.138 N/A CYS 192.A N LEU 187.A O no hydrogen 3.319 N/A CYS 192.A SG GLN 166.A O no hydrogen 3.485 N/A GLU 193.A N HIS 169.A O no hydrogen 3.030 N/A ILE 194.A N ASP 213.A OD2 no hydrogen 2.764 N/A THR 195.A N VAL 171.A O no hydrogen 3.005 N/A THR 195.A OG1 HIS 170.A NE2 no hydrogen 2.720 N/A ALA 196.A N HIS 214.A O no hydrogen 2.868 N/A PHE 197.A N VAL 173.A O no hydrogen 2.790 N/A SER 198.A N VAL 216.A O no hydrogen 2.990 N/A SER 198.A OG ASN 200.A O no hydrogen 3.321 N/A ASN 200.A N SER 198.A OG no hydrogen 3.189 N/A ASP 202.A N ASN 200.A OD1 no hydrogen 3.126 N/A LYS 203.A N ASN 200.A O no hydrogen 3.242 N/A THR 204.A OG1 PRO 201.A O no hydrogen 3.222 N/A LEU 207.A N LYS 203.A O no hydrogen 2.945 N/A LYS 208.A N THR 204.A O no hydrogen 3.092 N/A ALA 209.A N GLU 205.A O no hydrogen 3.035 N/A MET 210.A N GLU 206.A O no hydrogen 2.866 N/A GLY 211.A N LEU 207.A O no hydrogen 3.187 N/A GLY 211.A N LYS 208.A O no hydrogen 3.033 N/A ALA 212.A N LEU 207.A O no hydrogen 3.086 N/A ASP 213.A N ILE 194.A O no hydrogen 2.841 N/A HIS 214.A N ILE 194.A O no hydrogen 3.032 N/A HIS 214.A NE2 GLU 193.A OE2 no hydrogen 2.686 N/A VAL 216.A N ALA 196.A O no hydrogen 2.907 N/A SER 218.A N SER 198.A O no hydrogen 3.020 N/A ARG 219.A N ASN 217.A OD1 no hydrogen 2.921 N/A ASP 220.A N ASN 217.A O no hydrogen 3.035 N/A ALA 223.A N ASP 220.A OD1 no hydrogen 3.002 N/A VAL 224.A N ASP 220.A O no hydrogen 3.112 N/A LYS 225.A N THR 221.A O no hydrogen 2.992 N/A ALA 226.A N GLU 222.A O no hydrogen 3.014 N/A GLN 227.A N VAL 224.A O no hydrogen 2.941 N/A GLN 227.A NE2 ALA 223.A O no hydrogen 3.578 N/A LYS 228.A N LYS 225.A O no hydrogen 3.033 N/A GLY 229.A N SER 247.A O no hydrogen 3.002 N/A LYS 230.A N GLN 227.A O no hydrogen 3.341 N/A LYS 230.A NZ GLN 227.A OE1 no hydrogen 2.869 N/A PHE 231.A N THR 248.A O no hydrogen 2.931 N/A ASP 232.A N HIS 170.A O no hydrogen 2.848 N/A LEU 234.A N SER 254.A O no hydrogen 2.918 N/A LEU 235.A N GLY 172.A O no hydrogen 2.801 N/A SER 236.A N HIS 256.A O no hydrogen 3.110 N/A THR 237.A N ILE 174.A O no hydrogen 3.180 N/A THR 237.A OG1 ILE 174.A O no hydrogen 2.713 N/A THR 237.A OG1 GLY 175.A O no hydrogen 3.092 N/A VAL 238.A N SER 236.A OG no hydrogen 3.375 N/A PHE 245.A N ASN 241.A O no hydrogen 3.207 N/A ILE 246.A N TRP 242.A O no hydrogen 2.881 N/A SER 247.A N ARG 243.A O no hydrogen 3.105 N/A SER 247.A OG.A ARG 243.A O no hydrogen 3.229 N/A SER 247.A OG.B ALA 244.A O no hydrogen 2.487 N/A THR 248.A N PHE 245.A O no hydrogen 2.972 N/A THR 248.A OG1 PHE 245.A O no hydrogen 2.685 N/A LEU 249.A N ILE 246.A O no hydrogen 3.112 N/A ALA 250.A N PHE 231.A O no hydrogen 2.739 N/A ASN 252.A N GLY 275.A O no hydrogen 2.927 N/A GLY 253.A N ALA 250.A O no hydrogen 2.828 N/A SER 254.A N ASP 232.A O no hydrogen 3.155 N/A SER 254.A OG.A SER 278.A O no hydrogen 3.493 N/A SER 254.A OG.A SER 278.A OG.B no hydrogen 2.774 N/A SER 254.A OG.B SER 278.A OG.B no hydrogen 2.421 N/A LEU 255.A N SER 278.A O no hydrogen 2.850 N/A HIS 256.A N LEU 234.A O no hydrogen 2.829 N/A HIS 256.A ND1 HIS 163.A NE2 no hydrogen 3.176 N/A HIS 256.A NE2 SER 282.A OG no hydrogen 2.648 N/A PHE 257.A N THR 280.A O no hydrogen 2.857 N/A LEU 258.A N.A SER 236.A O no hydrogen 3.143 N/A LEU 258.A N.B SER 236.A O no hydrogen 3.110 N/A THR 261.A N GLY 259.A O.A no hydrogen 2.836 N/A SER 271.A N SER 268.A O no hydrogen 3.056 N/A SER 271.A N SER 268.A OG no hydrogen 2.928 N/A SER 271.A OG SER 268.A O no hydrogen 2.605 N/A SER 271.A OG SER 268.A OG no hydrogen 3.225 N/A ILE 273.A N VAL 269.A O no hydrogen 2.788 N/A ASP 274.A N GLY 270.A O no hydrogen 3.010 N/A ALA 276.A N ILE 273.A O no hydrogen 3.336 N/A LYS 277.A N LEU 272.A O no hydrogen 2.985 N/A LYS 277.A NZ ILE 246.A O no hydrogen 3.053 N/A LYS 277.A NZ LEU 249.A O no hydrogen 3.390 N/A SER 278.A N GLY 253.A O no hydrogen 3.131 N/A SER 278.A OG.B SER 254.A OG.A no hydrogen 2.774 N/A THR 280.A N LEU 255.A O no hydrogen 2.876 N/A THR 280.A OG1 GLY 281.A O no hydrogen 3.305 N/A SER 282.A OG HIS 256.A NE2 no hydrogen 2.648 N/A LEU 290.A N SER 286.A O no hydrogen 3.052 N/A ARG 291.A N PRO 287.A O no hydrogen 2.899 N/A GLN 292.A N ALA 288.A O no hydrogen 2.935 N/A LEU 293.A N ALA 289.A O no hydrogen 2.875 N/A LEU 294.A N LEU 290.A O no hydrogen 3.111 N/A LYS 295.A N ARG 291.A O no hydrogen 3.060 N/A PHE 296.A N GLN 292.A O no hydrogen 2.887 N/A ALA 297.A N LEU 293.A O no hydrogen 2.844 N/A ALA 298.A N LEU 294.A O no hydrogen 3.026 N/A ARG 299.A N LYS 295.A O no hydrogen 3.319 N/A ARG 299.A N PHE 296.A O no hydrogen 2.998 N/A LYS 300.A N.A PHE 296.A O no hydrogen 2.816 N/A LYS 300.A N.B PHE 296.A O no hydrogen 2.886 N/A LYS 301.A N.B ALA 297.A O no hydrogen 3.201 N/A GLN 305.A N HIS 181.A NE2 no hydrogen 3.214 N/A GLU 307.A N ARG 329.A O no hydrogen 2.820 N/A PHE 309.A N VAL 331.A O no hydrogen 2.934 N/A MET 311.A N LYS 333.A O no hydrogen 2.833 N/A SER 312.A N ASP 335.A OD1 no hydrogen 3.102 N/A SER 312.A OG ASP 335.A OD2 no hydrogen 2.666 N/A GLN 313.A N PRO 310.A O no hydrogen 2.872 N/A LEU 314.A N MET 311.A O no hydrogen 3.111 N/A ASN 315.A ND2 LEU 16.A O no hydrogen 2.965 N/A GLU 316.A N GLU 316.A OE1 no hydrogen 2.682 N/A ALA 317.A N GLN 313.A O no hydrogen 2.939 N/A ILE 318.A N LEU 314.A O no hydrogen 2.841 N/A GLU 319.A N ASN 315.A O no hydrogen 3.033 N/A ARG 320.A N GLU 316.A O no hydrogen 2.957 N/A ARG 320.A NE GLU 307.A OE1 no hydrogen 2.811 N/A ARG 320.A NH2 GLU 307.A OE2 no hydrogen 2.872 N/A LEU 321.A N ALA 317.A O no hydrogen 2.910 N/A HIS 322.A N ILE 318.A O no hydrogen 2.991 N/A SER 323.A N GLU 319.A O no hydrogen 3.044 N/A SER 323.A N ARG 320.A O no hydrogen 3.191 N/A SER 323.A OG ARG 320.A O no hydrogen 2.551 N/A GLY 324.A N LEU 321.A O no hydrogen 3.234 N/A GLN 325.A N SER 323.A OG no hydrogen 3.237 N/A ARG 327.A N GLU 307.A OE2 no hydrogen 3.021 N/A TYR 328.A N GLN 305.A O no hydrogen 2.837 N/A ARG 329.A N GLN 305.A O no hydrogen 3.146 N/A VAL 331.A N GLU 307.A O no hydrogen 2.953 N/A LEU 332.A N CYS 38.A O no hydrogen 2.732 N/A LYS 333.A N PHE 309.A O no hydrogen 2.774 N/A ALA 334.A N GLU 36.A O no hydrogen 3.034 N/A