Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6d8x_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASN 4.A N SER 7.A OG no hydrogen 2.872 N/A SER 7.A N ASN 4.A OD1 no hydrogen 2.799 N/A SER 7.A OG GLN 2.A O no hydrogen 3.362 N/A SER 7.A OG ASN 4.A O no hydrogen 2.941 N/A SER 7.A OG ASN 4.A OD1 no hydrogen 3.244 N/A ALA 8.A N ASN 4.A O no hydrogen 2.970 N/A ASP 9.A N PRO 5.A O no hydrogen 3.107 N/A LEU 10.A N GLU 6.A O no hydrogen 3.117 N/A ARG 11.A N SER 7.A O no hydrogen 2.899 N/A ARG 11.A NH1 GLN 219.A OE1 no hydrogen 2.953 N/A ARG 11.A NH2 GLN 219.A OE1 no hydrogen 3.046 N/A ALA 12.A N ALA 8.A O no hydrogen 2.919 N/A LEU 13.A N ASP 9.A O no hydrogen 3.021 N/A ALA 14.A N LEU 10.A O no hydrogen 3.085 N/A LYS 15.A N ARG 11.A O no hydrogen 3.035 N/A HIS 16.A N ALA 12.A O no hydrogen 2.924 N/A HIS 16.A NE2 SER 101.A O no hydrogen 2.566 N/A LEU 17.A N LEU 13.A O no hydrogen 3.044 N/A TYR 18.A N ALA 14.A O no hydrogen 2.942 N/A ASP 19.A N LYS 15.A O no hydrogen 2.936 N/A SER 20.A N HIS 16.A O no hydrogen 3.133 N/A SER 20.A OG HIS 16.A O no hydrogen 2.869 N/A SER 20.A OG SER 101.A OG.B no hydrogen 2.426 N/A TYR 21.A N LEU 17.A O no hydrogen 2.823 N/A TYR 21.A OH ASP 180.A OD1 no hydrogen 2.747 N/A ILE 22.A N TYR 18.A O no hydrogen 2.802 N/A LYS 23.A N ASP 19.A O no hydrogen 3.091 N/A LYS 23.A NZ ASP 19.A O no hydrogen 3.153 N/A SER 24.A N SER 20.A O no hydrogen 2.904 N/A SER 24.A N TYR 21.A O no hydrogen 3.311 N/A SER 24.A OG SER 20.A O no hydrogen 3.067 N/A SER 24.A OG GLU 97.A OE1 no hydrogen 3.276 N/A PHE 25.A N TYR 21.A O no hydrogen 3.101 N/A LYS 29.A N ASP 180.A OD1 no hydrogen 2.971 N/A LYS 29.A NZ LEU 178.A O no hydrogen 2.679 N/A ALA 30.A N ASP 180.A OD2 no hydrogen 2.992 N/A LYS 31.A N THR 28.A OG1 no hydrogen 3.259 N/A LYS 31.A NZ ASP 42.A OD1 no hydrogen 3.266 N/A ALA 32.A N THR 28.A O no hydrogen 2.930 N/A ARG 33.A N LYS 29.A O no hydrogen 2.739 N/A ARG 33.A NE SER 131.A O no hydrogen 3.242 N/A ARG 33.A NH1 MET 133.A O no hydrogen 3.185 N/A ARG 33.A NH2 SER 131.A O no hydrogen 2.732 N/A ARG 33.A NH2 MET 133.A O no hydrogen 2.410 N/A ALA 34.A N ALA 30.A O no hydrogen 3.129 N/A ILE 35.A N LYS 31.A O no hydrogen 3.074 N/A LEU 36.A N ALA 32.A O no hydrogen 2.849 N/A THR 37.A N ARG 33.A O no hydrogen 2.921 N/A THR 37.A OG1 ARG 33.A O no hydrogen 2.610 N/A THR 37.A OG1 ALA 34.A O no hydrogen 3.428 N/A GLY 38.A N ILE 35.A O no hydrogen 3.140 N/A LYS 39.A N ALA 34.A O no hydrogen 2.916 N/A LYS 39.A NZ THR 37.A O no hydrogen 3.317 N/A THR 41.A OG1 LYS 43.A O no hydrogen 3.019 N/A LYS 43.A N THR 41.A OG1 no hydrogen 3.090 N/A LYS 43.A NZ GLU 142.A O no hydrogen 3.060 N/A PHE 46.A N GLN 144.A O no hydrogen 3.000 N/A ILE 48.A N PHE 146.A O no hydrogen 2.710 N/A TYR 49.A N SER 53.A OG no hydrogen 2.895 N/A ASP 50.A N SER 53.A OG no hydrogen 2.941 N/A SER 53.A N ASP 50.A OD1 no hydrogen 2.845 N/A SER 53.A OG ASP 50.A O no hydrogen 2.901 N/A SER 53.A OG ASP 50.A OD1 no hydrogen 2.662 N/A LEU 54.A N ASP 50.A O no hydrogen 2.980 N/A MET 55.A N MET 51.A O no hydrogen 3.134 N/A MET 56.A N ASN 52.A O no hydrogen 3.077 N/A GLY 57.A N LEU 54.A O no hydrogen 3.221 N/A GLU 58.A N MET 55.A O no hydrogen 3.333 N/A LYS 60.A N GLY 57.A O no hydrogen 3.300 N/A ILE 61.A N GLU 58.A O no hydrogen 3.177 N/A LYS 64.A N GLN 82.A OE1 no hydrogen 2.885 N/A GLN 72.A N GLN 72.A OE1 no hydrogen 3.176 N/A GLU 75.A N GLU 71.A O no hydrogen 2.957 N/A VAL 76.A N GLN 72.A O no hydrogen 3.004 N/A ALA 77.A N SER 73.A O no hydrogen 3.290 N/A ILE 78.A N LYS 74.A O no hydrogen 3.070 N/A ARG 79.A N GLU 75.A O no hydrogen 3.221 N/A ARG 79.A NE GLU 75.A OE2 no hydrogen 3.007 N/A ARG 79.A NH2 GLU 75.A OE2 no hydrogen 2.389 N/A ILE 80.A N VAL 76.A O no hydrogen 3.202 N/A PHE 81.A N ALA 77.A O no hydrogen 2.918 N/A GLN 82.A N ILE 78.A O no hydrogen 2.892 N/A GLY 83.A N ARG 79.A O no hydrogen 2.930 N/A CYS 84.A N ILE 80.A O no hydrogen 2.879 N/A GLN 85.A N PHE 81.A O no hydrogen 2.988 N/A GLN 85.A NE2 SER 263.A O no hydrogen 3.314 N/A PHE 86.A N GLN 82.A O no hydrogen 3.102 N/A ARG 87.A N GLY 83.A O no hydrogen 3.236 N/A ARG 87.A NH2 GLU 94.A OE1 no hydrogen 3.132 N/A SER 88.A N CYS 84.A O no hydrogen 2.853 N/A VAL 89.A N GLN 85.A O no hydrogen 3.004 N/A GLU 90.A N PHE 86.A O no hydrogen 2.988 N/A ALA 91.A N ARG 87.A O no hydrogen 2.685 N/A VAL 92.A N SER 88.A O no hydrogen 2.903 N/A GLN 93.A N VAL 89.A O no hydrogen 3.465 N/A GLN 93.A NE2 VAL 89.A O no hydrogen 3.497 N/A GLU 94.A N GLU 90.A O no hydrogen 3.247 N/A ILE 95.A N ALA 91.A O no hydrogen 3.023 N/A THR 96.A N VAL 92.A O no hydrogen 2.970 N/A THR 96.A OG1 VAL 92.A O no hydrogen 3.247 N/A THR 96.A OG1 GLN 93.A O no hydrogen 3.123 N/A GLU 97.A N GLN 93.A O no hydrogen 3.132 N/A TYR 98.A N GLU 94.A O no hydrogen 3.042 N/A TYR 98.A OH ALA 184.A O no hydrogen 2.528 N/A ALA 99.A N ILE 95.A O no hydrogen 2.904 N/A LYS 100.A N GLU 97.A O no hydrogen 3.268 N/A SER 101.A N TYR 98.A O no hydrogen 3.134 N/A SER 101.A OG.A TYR 98.A O no hydrogen 2.481 N/A SER 101.A OG.B HIS 16.A NE2 no hydrogen 2.795 N/A SER 101.A OG.B SER 20.A OG no hydrogen 2.426 N/A ILE 102.A N ALA 99.A O no hydrogen 2.951 N/A PHE 105.A N ILE 102.A O no hydrogen 2.932 N/A LEU 108.A N PHE 105.A O no hydrogen 3.140 N/A ASN 111.A N ASP 109.A OD1 no hydrogen 2.749 N/A GLN 113.A N ASP 109.A O no hydrogen 3.029 N/A GLN 113.A NE2 VAL 106.A O no hydrogen 2.821 N/A GLN 113.A NE2 LEU 108.A O no hydrogen 2.721 N/A VAL 114.A N LEU 110.A O no hydrogen 3.049 N/A THR 115.A N ASN 111.A O no hydrogen 3.088 N/A THR 115.A OG1 ASN 111.A O no hydrogen 3.095 N/A LEU 116.A N ASP 112.A O no hydrogen 2.820 N/A LEU 117.A N GLN 113.A O no hydrogen 3.080 N/A LYS 118.A N VAL 114.A O no hydrogen 2.743 N/A LYS 118.A NZ ILE 271.A O no hydrogen 2.898 N/A LYS 118.A NZ LYS 273.A O no hydrogen 2.730 N/A TYR 119.A N THR 115.A O no hydrogen 3.114 N/A GLY 120.A N LEU 116.A O no hydrogen 2.990 N/A GLY 120.A N LEU 117.A O no hydrogen 3.301 N/A VAL 121.A N LEU 117.A O no hydrogen 3.140 N/A ILE 124.A N GLY 120.A O no hydrogen 3.018 N/A ILE 125.A N VAL 121.A O no hydrogen 2.736 N/A TYR 126.A N HIS 122.A O no hydrogen 3.062 N/A THR 127.A N GLU 123.A O no hydrogen 3.050 N/A THR 127.A OG1 GLU 123.A O no hydrogen 2.841 N/A MET 128.A N ILE 124.A O no hydrogen 2.858 N/A LEU 129.A N ILE 125.A O no hydrogen 2.816 N/A SER 131.A N MET 128.A O no hydrogen 3.107 N/A LEU 132.A N LEU 129.A O no hydrogen 2.978 N/A MET 133.A N ALA 130.A O no hydrogen 3.063 N/A ASN 134.A N GLY 137.A O no hydrogen 2.978 N/A ASP 136.A N ASN 134.A OD1 no hydrogen 2.926 N/A GLY 137.A N ASN 134.A OD1 no hydrogen 2.990 N/A VAL 138.A N MET 147.A O no hydrogen 2.912 N/A LEU 139.A N LEU 132.A O no hydrogen 2.915 N/A ILE 140.A N GLY 145.A O no hydrogen 2.770 N/A SER 141.A OG LYS 60.A O no hydrogen 2.427 N/A GLY 143.A N ILE 140.A O no hydrogen 3.149 N/A GLN 144.A N SER 141.A O no hydrogen 3.080 N/A GLY 145.A N ILE 140.A O no hydrogen 3.002 N/A PHE 146.A N PHE 46.A O no hydrogen 2.835 N/A MET 147.A N VAL 138.A O no hydrogen 2.969 N/A THR 148.A N ILE 48.A O no hydrogen 3.053 N/A ARG 149.A N ASP 136.A O no hydrogen 2.726 N/A ARG 149.A NE GLU 164.A OE1 no hydrogen 2.694 N/A ARG 149.A NH2 GLU 164.A OE2 no hydrogen 3.398 N/A PHE 151.A N THR 148.A OG1 no hydrogen 3.170 N/A LEU 152.A N THR 148.A O no hydrogen 3.167 N/A LYS 153.A N ARG 149.A O no hydrogen 2.924 N/A LYS 153.A NZ GLU 150.A OE2 no hydrogen 2.810 N/A SER 154.A N PHE 151.A O no hydrogen 3.000 N/A SER 154.A OG GLU 150.A O no hydrogen 3.537 N/A SER 154.A OG PHE 151.A O no hydrogen 2.644 N/A ARG 156.A NH2 SER 73.A OG no hydrogen 2.993 N/A LYS 157.A NZ ASP 161.A OD2 no hydrogen 2.399 N/A PHE 159.A N ARG 156.A O no hydrogen 2.718 N/A ASP 161.A N PRO 158.A O no hydrogen 3.171 N/A PHE 162.A N PHE 159.A O no hydrogen 3.483 N/A LYS 166.A N MET 163.A O no hydrogen 2.891 N/A LYS 166.A NZ PHE 162.A O no hydrogen 3.052 N/A LYS 166.A NZ HIS 248.A ND1 no hydrogen 2.910 N/A PHE 167.A N MET 163.A O no hydrogen 3.102 N/A GLU 168.A N GLU 164.A O no hydrogen 2.972 N/A PHE 169.A N PRO 165.A O no hydrogen 2.995 N/A ALA 170.A N LYS 166.A O no hydrogen 2.809 N/A VAL 171.A N PHE 167.A O no hydrogen 2.973 N/A PHE 173.A N PHE 169.A O no hydrogen 2.843 N/A ASN 174.A N ALA 170.A O no hydrogen 2.742 N/A ASN 174.A ND2 ALA 130.A O no hydrogen 3.064 N/A ALA 175.A N LYS 172.A O no hydrogen 3.234 N/A LEU 176.A N PHE 173.A O no hydrogen 2.984 N/A GLU 177.A N ASN 174.A O no hydrogen 3.013 N/A ASP 179.A N ASP 182.A OD2 no hydrogen 3.034 N/A SER 181.A OG ASP 179.A OD1 no hydrogen 2.643 N/A ASP 182.A N ASP 179.A OD1 no hydrogen 3.073 N/A LEU 183.A N ASP 179.A O no hydrogen 2.853 N/A ALA 184.A N ASP 180.A O no hydrogen 2.932 N/A PHE 186.A N ASP 182.A O no hydrogen 3.116 N/A ILE 187.A N LEU 183.A O no hydrogen 2.995 N/A VAL 189.A N ILE 185.A O no hydrogen 2.899 N/A ILE 190.A N PHE 186.A O no hydrogen 3.044 N/A ILE 191.A N ILE 187.A O no hydrogen 3.039 N/A LEU 192.A N ALA 188.A O no hydrogen 3.099 N/A SER 193.A OG ILE 190.A O no hydrogen 2.659 N/A ARG 196.A NH1 GLU 123.A OE1 no hydrogen 2.891 N/A ARG 196.A NH1 GLU 123.A OE2 no hydrogen 3.489 N/A ARG 196.A NH2 GLU 123.A OE2 no hydrogen 2.715 N/A ARG 196.A NH2 ILE 190.A O no hydrogen 3.216 N/A LEU 200.A N ASP 112.A OD1 no hydrogen 2.783 N/A LEU 200.A N ASP 112.A OD2 no hydrogen 3.250 N/A ASN 201.A N ASP 112.A OD2 no hydrogen 2.940 N/A LYS 203.A NZ ASP 207.A OD1 no hydrogen 3.257 N/A LYS 203.A NZ ASP 207.A OD2 no hydrogen 3.053 N/A GLU 206.A N VAL 202.A O no hydrogen 2.963 N/A ASP 207.A N LYS 203.A O no hydrogen 2.874 N/A ILE 208.A N PRO 204.A O no hydrogen 3.077 N/A GLN 209.A N ILE 205.A O no hydrogen 2.983 N/A GLN 209.A NE2 VAL 189.A O no hydrogen 2.950 N/A ASP 210.A N GLU 206.A O no hydrogen 2.925 N/A ASN 211.A N ASP 207.A O no hydrogen 3.282 N/A LEU 212.A N ILE 208.A O no hydrogen 2.921 N/A LEU 213.A N GLN 209.A O no hydrogen 2.746 N/A GLN 214.A N ASP 210.A O no hydrogen 3.113 N/A GLN 214.A NE2 ASP 210.A OD1 no hydrogen 2.855 N/A ALA 215.A N ASN 211.A O no hydrogen 3.172 N/A LEU 216.A N LEU 212.A O no hydrogen 2.800 N/A GLU 217.A N LEU 213.A O no hydrogen 2.872 N/A LEU 218.A N GLN 214.A O no hydrogen 3.052 N/A GLN 219.A N ALA 215.A O no hydrogen 2.816 N/A GLN 219.A NE2 ASP 182.A OD1 no hydrogen 2.730 N/A LEU 220.A N LEU 216.A O no hydrogen 2.966 N/A LYS 221.A N GLU 217.A O no hydrogen 3.141 N/A LEU 222.A N LEU 218.A O no hydrogen 3.001 N/A ASN 223.A N GLN 219.A O no hydrogen 2.943 N/A ASN 223.A ND2 ASP 179.A OD2 no hydrogen 2.816 N/A ASN 223.A ND2 ASP 182.A OD1 no hydrogen 3.054 N/A ASN 223.A ND2 ASP 182.A OD2 no hydrogen 3.234 N/A ASN 223.A ND2 HIS 224.A NE2 no hydrogen 3.602 N/A HIS 224.A N LEU 220.A O no hydrogen 2.911 N/A HIS 224.A NE2 ASP 182.A OD2 no hydrogen 2.554 N/A SER 227.A N HIS 224.A O no hydrogen 3.330 N/A LYS 233.A N GLN 229.A O no hydrogen 2.916 N/A LYS 233.A NZ SER 228.A O no hydrogen 3.193 N/A LEU 234.A N LEU 230.A O no hydrogen 2.868 N/A LEU 235.A N PHE 231.A O no hydrogen 3.039 N/A GLN 236.A N ALA 232.A O no hydrogen 3.002 N/A LYS 237.A N LYS 233.A O no hydrogen 3.287 N/A LYS 237.A N LEU 234.A O no hydrogen 2.932 N/A MET 238.A N LEU 235.A O no hydrogen 3.102 N/A THR 239.A N GLN 236.A O no hydrogen 3.075 N/A LEU 241.A N LYS 237.A O no hydrogen 2.886 N/A ARG 242.A N MET 238.A O no hydrogen 3.232 N/A ARG 242.A NH1 ASP 195.A OD2 no hydrogen 3.507 N/A ARG 242.A NH2 ASP 195.A OD1 no hydrogen 2.919 N/A ARG 242.A NH2 ASP 195.A OD2 no hydrogen 3.245 N/A GLN 243.A N THR 239.A O no hydrogen 3.249 N/A ILE 244.A N ASP 240.A O no hydrogen 3.107 N/A VAL 245.A N LEU 241.A O no hydrogen 3.101 N/A THR 246.A N ARG 242.A O no hydrogen 3.032 N/A THR 246.A OG1 ARG 242.A O no hydrogen 3.348 N/A GLU 247.A N GLN 243.A O no hydrogen 2.800 N/A HIS 248.A N ILE 244.A O no hydrogen 2.822 N/A VAL 249.A N VAL 245.A O no hydrogen 2.930 N/A GLN 250.A N THR 246.A O no hydrogen 3.229 N/A LEU 251.A N GLU 247.A O no hydrogen 3.230 N/A LEU 252.A N HIS 248.A O no hydrogen 2.956 N/A GLN 253.A N VAL 249.A O no hydrogen 2.957 N/A VAL 254.A N GLN 250.A O no hydrogen 3.368 N/A LYS 256.A N LEU 252.A O no hydrogen 3.245 N/A LYS 257.A N GLN 253.A O no hydrogen 3.151 N/A THR 258.A N VAL 254.A O no hydrogen 2.638 N/A THR 258.A OG1 VAL 254.A O no hydrogen 2.720 N/A GLU 259.A N ILE 255.A O no hydrogen 2.699 N/A HIS 265.A N GLN 85.A OE1 no hydrogen 3.061 N/A LEU 267.A N HIS 265.A ND1 no hydrogen 2.884 N/A GLN 269.A N HIS 265.A O no hydrogen 2.945 N/A GLU 270.A N PRO 266.A O no hydrogen 2.677 N/A ILE 271.A N LEU 267.A O no hydrogen 2.899 N/A TYR 272.A N LEU 268.A O no hydrogen 2.865 N/A LYS 273.A N GLN 269.A O no hydrogen 2.727 N/A LYS 273.A NZ ASP 274.A OD2 no hydrogen 3.560 N/A LEU 275.A N TYR 272.A O no hydrogen 3.034 N/A