Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6hx4_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 6.A N ILE 2.A O no hydrogen 2.888 N/A ALA 7.A N THR 3.A O no hydrogen 2.620 N/A GLU 8.A N PRO 4.A O no hydrogen 3.280 N/A PHE 9.A N ASN 5.A O no hydrogen 3.214 N/A ALA 10.A N LEU 6.A O no hydrogen 2.944 N/A PHE 11.A N ALA 7.A O no hydrogen 3.200 N/A SER 12.A N GLU 8.A O no hydrogen 3.115 N/A SER 12.A OG GLU 8.A O no hydrogen 2.869 N/A SER 12.A OG PHE 9.A O no hydrogen 3.071 N/A LEU 13.A N PHE 9.A O no hydrogen 2.932 N/A TYR 14.A N ALA 10.A O no hydrogen 2.806 N/A TYR 14.A OH GLU 229.A OE1 no hydrogen 2.365 N/A ARG 15.A N PHE 11.A O no hydrogen 2.608 N/A ARG 15.A NE GLU 229.A O no hydrogen 3.015 N/A ARG 15.A NH2 GLU 229.A O no hydrogen 3.423 N/A GLN 16.A N SER 12.A O no hydrogen 3.292 N/A LEU 17.A N TYR 14.A O no hydrogen 2.783 N/A ALA 18.A N TYR 14.A O no hydrogen 3.038 N/A GLN 20.A N GLN 16.A O no hydrogen 3.472 N/A ASN 24.A ND2 ASN 341.A O no hydrogen 2.913 N/A ILE 25.A N LYS 338.A O no hydrogen 3.076 N/A PHE 26.A N TYR 262.A OH no hydrogen 3.098 N/A PHE 27.A N MET 336.A O no hydrogen 3.234 N/A SER 28.A N HIS 299.A NE2 no hydrogen 3.078 N/A SER 28.A OG LEU 334.A O no hydrogen 3.021 N/A SER 31.A N SER 28.A OG no hydrogen 3.214 N/A SER 31.A OG ASN 155.A OD1 no hydrogen 2.725 N/A ILE 32.A N SER 28.A O no hydrogen 3.056 N/A ALA 33.A N PRO 29.A O no hydrogen 2.894 N/A THR 34.A N VAL 30.A O no hydrogen 2.820 N/A THR 34.A OG1 VAL 30.A O no hydrogen 2.661 N/A THR 34.A OG1 SER 31.A O no hydrogen 2.978 N/A ALA 35.A N SER 31.A O no hydrogen 2.990 N/A PHE 36.A N ILE 32.A O no hydrogen 3.334 N/A ALA 37.A N ALA 33.A O no hydrogen 2.940 N/A MET 38.A N THR 34.A O no hydrogen 2.863 N/A LEU 39.A N ALA 35.A O no hydrogen 3.001 N/A SER 40.A N PHE 36.A O no hydrogen 2.938 N/A SER 40.A OG ALA 37.A O no hydrogen 2.333 N/A LEU 41.A N MET 38.A O no hydrogen 3.163 N/A GLY 42.A N LEU 39.A O no hydrogen 3.260 N/A THR 43.A N SER 40.A O no hydrogen 3.269 N/A THR 43.A OG1 SER 40.A O no hydrogen 2.492 N/A THR 43.A OG1 HIS 48.A ND1 no hydrogen 2.987 N/A LYS 44.A N ASP 282.A O no hydrogen 3.281 N/A HIS 48.A N LYS 44.A O no hydrogen 2.344 N/A HIS 48.A ND1 SER 40.A O no hydrogen 2.703 N/A HIS 48.A ND1 THR 43.A OG1 no hydrogen 2.987 N/A ASP 49.A N ALA 45.A O no hydrogen 2.850 N/A LEU 52.A N HIS 48.A O no hydrogen 3.479 N/A GLU 53.A N ASP 49.A O no hydrogen 2.937 N/A GLY 54.A N GLU 50.A O no hydrogen 2.643 N/A LEU 55.A N LEU 52.A O no hydrogen 3.082 N/A ASN 56.A N GLU 53.A O no hydrogen 3.172 N/A PHE 57.A N LEU 52.A O no hydrogen 3.182 N/A HIS 64.A ND1 TYR 107.A OH no hydrogen 2.465 N/A GLY 66.A N GLN 62.A O no hydrogen 3.052 N/A PHE 67.A N ILE 63.A O no hydrogen 2.535 N/A GLN 68.A N HIS 64.A O no hydrogen 2.524 N/A GLU 69.A N GLU 65.A O no hydrogen 2.460 N/A LEU 70.A N GLY 66.A O no hydrogen 2.949 N/A LEU 71.A N PHE 67.A O no hydrogen 2.736 N/A ARG 72.A N GLN 68.A O no hydrogen 2.592 N/A THR 73.A N GLU 69.A O no hydrogen 2.725 N/A THR 73.A OG1 GLU 69.A O no hydrogen 2.866 N/A LEU 74.A N LEU 70.A O no hydrogen 2.848 N/A ASN 75.A N ARG 72.A O no hydrogen 3.051 N/A SER 77.A OG ASN 75.A O no hydrogen 2.570 N/A THR 82.A N PHE 158.A O no hydrogen 2.976 N/A GLY 84.A N TYR 156.A O no hydrogen 3.210 N/A GLY 86.A N VAL 154.A O no hydrogen 2.800 N/A LEU 87.A N GLU 110.A O no hydrogen 2.985 N/A PHE 88.A N ALA 152.A O no hydrogen 2.862 N/A LEU 89.A N PHE 112.A O no hydrogen 2.934 N/A SER 90.A N VAL 150.A O no hydrogen 3.335 N/A GLU 91.A N VAL 114.A O no hydrogen 2.768 N/A VAL 96.A N VAL 286.A O no hydrogen 3.016 N/A PHE 99.A N VAL 96.A O no hydrogen 3.281 N/A VAL 103.A N PHE 99.A O no hydrogen 3.087 N/A LYS 104.A N GLU 101.A O no hydrogen 3.169 N/A LYS 105.A N GLU 101.A O no hydrogen 2.876 N/A LEU 106.A N ASP 102.A O no hydrogen 2.993 N/A TYR 107.A OH HIS 64.A ND1 no hydrogen 2.465 N/A HIS 108.A N LYS 104.A O no hydrogen 3.216 N/A SER 109.A N VAL 103.A O no hydrogen 2.907 N/A GLU 110.A N ASN 85.A O no hydrogen 3.283 N/A PHE 112.A N LEU 87.A O no hydrogen 2.743 N/A VAL 114.A N LEU 89.A O no hydrogen 2.718 N/A GLY 117.A N ASN 115.A OD1 no hydrogen 3.046 N/A ASP 118.A N ASN 115.A O no hydrogen 3.297 N/A THR 119.A OG1 LEU 145.A O no hydrogen 3.139 N/A GLU 121.A N ASP 118.A OD1 no hydrogen 3.199 N/A ALA 122.A N ASP 118.A O no hydrogen 2.937 N/A LYS 123.A N THR 119.A O no hydrogen 3.208 N/A LYS 123.A NZ GLU 120.A OE2 no hydrogen 3.203 N/A LYS 124.A N GLU 120.A O no hydrogen 3.281 N/A GLN 125.A N GLU 121.A O no hydrogen 3.073 N/A ILE 126.A N ALA 122.A O no hydrogen 3.121 N/A ASN 127.A N LYS 123.A O no hydrogen 3.057 N/A ASN 127.A ND2 VAL 142.A O no hydrogen 3.250 N/A ASP 128.A N LYS 124.A O no hydrogen 2.910 N/A TYR 129.A N GLN 125.A O no hydrogen 3.089 N/A VAL 130.A N ILE 126.A O no hydrogen 3.123 N/A GLU 131.A N ASN 127.A O no hydrogen 2.691 N/A LYS 132.A N ASP 128.A O no hydrogen 2.760 N/A GLY 133.A N TYR 129.A O no hydrogen 2.870 N/A THR 134.A N VAL 130.A O no hydrogen 2.738 N/A THR 134.A OG1 VAL 130.A O no hydrogen 2.650 N/A THR 134.A OG1 ILE 138.A O no hydrogen 3.337 N/A GLY 136.A N GLU 131.A O no hydrogen 3.286 N/A LYS 137.A N THR 134.A O no hydrogen 3.108 N/A ILE 138.A N THR 134.A OG1 no hydrogen 3.211 N/A VAL 142.A N ASN 127.A OD1 no hydrogen 2.750 N/A ASP 148.A N ASP 146.A OD1 no hydrogen 3.069 N/A THR 149.A OG1 ASP 146.A O no hydrogen 2.764 N/A VAL 150.A N SER 295.A OG no hydrogen 3.040 N/A ALA 152.A N PHE 88.A O no hydrogen 2.861 N/A LEU 153.A N LYS 296.A O no hydrogen 2.922 N/A VAL 154.A N GLY 86.A O no hydrogen 2.914 N/A ASN 155.A N VAL 298.A O no hydrogen 2.958 N/A ASN 155.A ND2 SER 31.A OG no hydrogen 2.562 N/A ASN 155.A ND2 ASN 85.A OD1 no hydrogen 2.275 N/A TYR 156.A N GLY 84.A O no hydrogen 3.233 N/A ILE 157.A N LYS 300.A O no hydrogen 2.949 N/A PHE 158.A N THR 82.A O no hydrogen 2.748 N/A PHE 159.A N VAL 302.A O no hydrogen 3.182 N/A LYS 160.A N GLN 80.A O no hydrogen 3.488 N/A TRP 163.A NE1 ASP 306.A O no hydrogen 2.552 N/A GLU 164.A N LYS 208.A O no hydrogen 3.201 N/A THR 169.A OG1 GLU 307.A OE2 no hydrogen 3.021 N/A GLU 170.A N MET 185.A O no hydrogen 3.112 N/A GLU 172.A N VAL 183.A O no hydrogen 2.779 N/A PHE 174.A N VAL 181.A O no hydrogen 2.351 N/A HIS 175.A N ASN 318.A O no hydrogen 2.642 N/A ASP 177.A N THR 179.A OG1 no hydrogen 2.491 N/A THR 179.A OG1 ASP 177.A O no hydrogen 2.859 N/A THR 180.A N THR 179.A OG1 no hydrogen 2.893 N/A THR 180.A OG1 THR 179.A O no hydrogen 2.533 N/A THR 180.A OG1 THR 180.A O no hydrogen 2.546 N/A VAL 181.A N PHE 174.A O no hydrogen 2.768 N/A VAL 183.A N GLU 172.A O no hydrogen 2.786 N/A MET 185.A N GLU 170.A O no hydrogen 2.512 N/A MET 186.A N LEU 253.A O no hydrogen 2.774 N/A ARG 188.A N LEU 251.A O no hydrogen 3.000 N/A GLY 190.A N ALA 249.A O no hydrogen 3.125 N/A PHE 192.A N ARG 247.A O no hydrogen 2.904 N/A GLN 195.A N VAL 204.A O no hydrogen 3.046 N/A GLN 195.A NE2 HIS 196.A O no hydrogen 2.886 N/A HIS 196.A NE2 ASP 221.A OD1 no hydrogen 3.099 N/A CYS 197.A N SER 202.A O no hydrogen 3.027 N/A SER 201.A OG ASP 221.A OD2 no hydrogen 2.981 N/A SER 202.A OG LEU 200.A O no hydrogen 3.036 N/A TRP 203.A N LEU 219.A O no hydrogen 2.658 N/A VAL 204.A N GLN 195.A O no hydrogen 2.823 N/A LEU 205.A N PHE 217.A O no hydrogen 2.935 N/A LEU 206.A N ASN 193.A O no hydrogen 3.063 N/A MET 207.A N ALA 215.A O no hydrogen 3.042 N/A TYR 209.A N ALA 213.A O no hydrogen 2.451 N/A LEU 210.A N LYS 162.A O no hydrogen 2.411 N/A THR 214.A N ILE 326.A O no hydrogen 2.730 N/A ALA 215.A N MET 207.A O no hydrogen 2.802 N/A ILE 216.A N LEU 324.A O no hydrogen 2.542 N/A PHE 217.A N LEU 205.A O no hydrogen 2.838 N/A PHE 218.A N VAL 322.A O no hydrogen 2.550 N/A LEU 219.A N TRP 203.A O no hydrogen 2.861 N/A ASP 221.A N SER 201.A O no hydrogen 3.100 N/A HIS 227.A NE2 LYS 199.A O no hydrogen 3.188 N/A LEU 228.A N LYS 224.A O no hydrogen 3.214 N/A GLU 229.A N LEU 225.A O no hydrogen 3.237 N/A ASN 230.A N GLN 226.A O no hydrogen 3.226 N/A GLU 231.A N HIS 227.A O no hydrogen 3.060 N/A ILE 236.A N THR 233.A OG1 no hydrogen 3.321 N/A THR 238.A N HIS 234.A O no hydrogen 3.178 N/A THR 238.A OG1 HIS 234.A O no hydrogen 3.393 N/A THR 238.A OG1 ASP 235.A O no hydrogen 2.636 N/A LYS 239.A N ASP 235.A O no hydrogen 3.282 N/A PHE 240.A N ILE 236.A O no hydrogen 3.217 N/A LEU 241.A N ILE 237.A O no hydrogen 2.729 N/A GLU 242.A N THR 238.A O no hydrogen 2.831 N/A ASN 243.A N PHE 240.A O no hydrogen 3.210 N/A ASN 243.A ND2 ASP 245.A OD2 no hydrogen 3.444 N/A ARG 247.A N PHE 192.A O no hydrogen 3.064 N/A ALA 249.A N GLY 190.A O no hydrogen 3.037 N/A SER 250.A N PRO 313.A O no hydrogen 3.039 N/A LEU 251.A N ARG 188.A O no hydrogen 2.907 N/A HIS 252.A N VAL 315.A O no hydrogen 2.960 N/A LEU 253.A N MET 186.A O no hydrogen 2.820 N/A LYS 255.A N PRO 184.A O no hydrogen 3.306 N/A SER 257.A OG LEU 303.A O no hydrogen 3.410 N/A ILE 258.A N LEU 303.A O no hydrogen 3.133 N/A GLY 260.A N ALA 301.A O no hydrogen 2.673 N/A TYR 262.A N HIS 299.A O no hydrogen 2.951 N/A LEU 264.A N ALA 297.A O no hydrogen 2.508 N/A SER 266.A N ASP 263.A O no hydrogen 3.223 N/A SER 266.A OG ASP 263.A O no hydrogen 2.967 N/A VAL 267.A N ASP 263.A O no hydrogen 3.497 N/A LEU 268.A N LEU 264.A O no hydrogen 2.997 N/A GLY 269.A N LYS 265.A O no hydrogen 3.082 N/A GLN 270.A N SER 266.A O no hydrogen 3.385 N/A LEU 271.A N LEU 268.A O no hydrogen 3.074 N/A GLY 272.A N GLY 269.A O no hydrogen 3.427 N/A ILE 273.A N LEU 268.A O no hydrogen 3.061 N/A THR 274.A N GLU 50.A OE1 no hydrogen 2.967 N/A THR 274.A OG1 GLU 50.A OE1 no hydrogen 3.454 N/A THR 274.A OG1 GLU 50.A OE2 no hydrogen 3.519 N/A LYS 275.A N GLU 50.A OE1 no hydrogen 2.702 N/A PHE 277.A N THR 274.A O no hydrogen 3.303 N/A SER 278.A N THR 274.A O no hydrogen 3.060 N/A SER 278.A N LYS 275.A O no hydrogen 3.298 N/A SER 278.A OG THR 274.A O no hydrogen 3.516 N/A SER 278.A OG LYS 275.A O no hydrogen 3.050 N/A ASP 282.A N THR 47.A OG1 no hydrogen 3.203 N/A SER 284.A N ASP 282.A OD1 no hydrogen 3.421 N/A SER 284.A OG ASP 282.A OD1 no hydrogen 3.371 N/A VAL 286.A N LEU 283.A O no hydrogen 2.796 N/A THR 287.A N LEU 283.A O no hydrogen 3.162 N/A THR 287.A OG1 LYS 94.A O no hydrogen 3.258 N/A LEU 294.A N VAL 276.A O no hydrogen 2.604 N/A SER 295.A N PHE 151.A O no hydrogen 2.849 N/A LYS 296.A N PHE 151.A O no hydrogen 3.338 N/A LYS 296.A NZ GLU 144.A O no hydrogen 3.353 N/A VAL 298.A N LEU 153.A O no hydrogen 3.086 N/A HIS 299.A N TYR 262.A O no hydrogen 2.937 N/A HIS 299.A ND1 ASN 155.A OD1 no hydrogen 2.553 N/A LYS 300.A N ASN 155.A O no hydrogen 2.866 N/A ALA 301.A N GLY 260.A O no hydrogen 2.832 N/A VAL 302.A N ILE 157.A O no hydrogen 3.061 N/A LEU 303.A N ILE 258.A O no hydrogen 2.772 N/A THR 304.A N PHE 159.A O no hydrogen 3.243 N/A THR 304.A OG1 PHE 159.A O no hydrogen 2.954 N/A ILE 305.A N LEU 256.A O no hydrogen 2.900 N/A GLU 307.A N GLU 307.A OE1 no hydrogen 2.674 N/A VAL 315.A N SER 250.A O no hydrogen 3.045 N/A PHE 317.A N HIS 252.A O no hydrogen 2.843 N/A LYS 319.A NZ PRO 220.A O no hydrogen 2.283 N/A LYS 319.A NZ ASP 221.A O no hydrogen 3.352 N/A PHE 321.A N VAL 339.A O no hydrogen 3.353 N/A VAL 322.A N PHE 218.A O no hydrogen 2.971 N/A PHE 323.A N GLY 337.A O no hydrogen 3.063 N/A LEU 324.A N ILE 216.A O no hydrogen 2.695 N/A MET 325.A N PHE 335.A O no hydrogen 2.977 N/A ILE 326.A N THR 214.A O no hydrogen 2.706 N/A GLU 327.A N SER 332.A O no hydrogen 3.143 N/A GLN 328.A N ASN 212.A O no hydrogen 2.931 N/A THR 330.A OG1 SER 332.A OG no hydrogen 2.657 N/A LYS 331.A N GLU 327.A O no hydrogen 2.631 N/A SER 332.A OG THR 330.A OG1 no hydrogen 2.657 N/A LEU 334.A N MET 325.A O no hydrogen 2.771 N/A PHE 335.A N MET 325.A O no hydrogen 3.232 N/A MET 336.A N PHE 27.A O no hydrogen 3.204 N/A GLY 337.A N PHE 323.A O no hydrogen 3.209 N/A LYS 338.A N ILE 25.A O no hydrogen 2.961 N/A VAL 339.A N PHE 321.A O no hydrogen 3.009 N/A VAL 340.A N ASN 24.A OD1 no hydrogen 2.754 N/A ASN 341.A N ASN 24.A OD1 no hydrogen 3.266 N/A THR 343.A N ASN 341.A OD1 no hydrogen 3.446 N/A