Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6npn_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): PHE 3.A N TYR 28.A OH no hydrogen 3.386 N/A ALA 4.A N GLU 7.A OE2 no hydrogen 3.018 N/A GLY 6.A N VAL 19.A O no hydrogen 2.977 N/A GLU 7.A N ALA 4.A O no hydrogen 2.973 N/A ILE 9.A N TRP 17.A O no hydrogen 2.824 N/A ASP 11.A N ALA 15.A O no hydrogen 2.888 N/A MET 12.A N SER 92.A O no hydrogen 2.893 N/A ALA 13.A N ASP 11.A OD1 no hydrogen 2.935 N/A ALA 14.A N ASP 11.A O no hydrogen 2.923 N/A ALA 15.A N ASP 11.A OD1 no hydrogen 2.952 N/A TRP 17.A N ILE 9.A O no hydrogen 2.819 N/A TRP 17.A NE1 ASP 11.A OD2 no hydrogen 2.928 N/A LYS 18.A N ASP 31.A O no hydrogen 2.766 N/A LYS 18.A NZ SER 34.A O no hydrogen 2.461 N/A LYS 18.A NZ GLU 36.A O no hydrogen 3.059 N/A VAL 19.A N GLU 7.A O no hydrogen 2.954 N/A GLY 20.A N LEU 29.A O no hydrogen 2.779 N/A ILE 23.A N ILE 27.A O no hydrogen 3.015 N/A TYR 28.A N VAL 46.A O no hydrogen 2.975 N/A LEU 29.A N LEU 21.A O no hydrogen 3.041 N/A ALA 30.A N CYS 44.A O no hydrogen 2.950 N/A ASP 31.A N LYS 18.A O no hydrogen 3.040 N/A MET 32.A N ASP 31.A OD1 no hydrogen 2.726 N/A ASN 33.A N ALA 16.A O no hydrogen 3.167 N/A SER 34.A OG GLU 36.A O no hydrogen 3.320 N/A ALA 42.A N GLY 39.A O no hydrogen 3.324 N/A CYS 44.A N ALA 30.A O no hydrogen 3.278 N/A VAL 45.A N MET 107.A O no hydrogen 2.858 N/A VAL 46.A N TYR 28.A O no hydrogen 2.804 N/A LYS 47.A N MET 105.A O no hydrogen 2.882 N/A LYS 47.A NZ GLU 59.A OE1 no hydrogen 2.729 N/A LYS 47.A NZ GLU 59.A OE2 no hydrogen 3.488 N/A VAL 48.A N CYS 26.A O no hydrogen 3.047 N/A GLU 49.A N ARG 103.A O no hydrogen 3.040 N/A SER 51.A N SER 101.A O no hydrogen 3.009 N/A ASN 53.A N PRO 50.A O no hydrogen 3.053 N/A LEU 56.A N ASN 53.A OD1 no hydrogen 2.985 N/A THR 58.A N GLY 54.A O no hydrogen 2.978 N/A THR 58.A OG1 GLY 54.A O no hydrogen 3.336 N/A GLU 59.A N PRO 55.A O no hydrogen 2.892 N/A LEU 60.A N LEU 56.A O no hydrogen 2.785 N/A LYS 61.A N PHE 57.A O no hydrogen 2.984 N/A PHE 62.A N THR 58.A O no hydrogen 3.056 N/A TYR 63.A N GLU 59.A O no hydrogen 2.952 N/A GLN 64.A N LEU 60.A O no hydrogen 2.874 N/A GLN 64.A NE2 TYR 89.A OH no hydrogen 3.210 N/A ARG 65.A N LYS 61.A O no hydrogen 2.949 N/A ARG 65.A NH1 TYR 149.A OH no hydrogen 2.666 N/A ALA 66.A N PHE 62.A O no hydrogen 2.895 N/A ALA 67.A N TYR 63.A O no hydrogen 2.928 N/A LYS 68.A N GLN 71.A OE1 no hydrogen 3.170 N/A LYS 68.A NZ GLN 64.A O no hydrogen 2.878 N/A LYS 68.A NZ ARG 65.A O no hydrogen 3.299 N/A LYS 68.A NZ GLN 71.A OE1 no hydrogen 3.180 N/A GLU 70.A N GLU 70.A OE1 no hydrogen 2.734 N/A GLN 71.A NE2 ARG 65.A O no hydrogen 2.840 N/A ILE 72.A N LYS 68.A O no hydrogen 3.005 N/A GLN 73.A N PRO 69.A O no hydrogen 2.895 N/A LYS 74.A N GLU 70.A O no hydrogen 2.874 N/A TRP 75.A N GLN 71.A O no hydrogen 3.279 N/A ILE 76.A N ILE 72.A O no hydrogen 3.029 N/A ARG 77.A N GLN 73.A O no hydrogen 3.039 N/A THR 78.A N LYS 74.A O no hydrogen 2.927 N/A THR 78.A OG1 LYS 74.A O no hydrogen 2.965 N/A ARG 79.A N TRP 75.A O no hydrogen 2.831 N/A ARG 79.A NH2 GLU 142.A OE2 no hydrogen 3.083 N/A LYS 80.A N ARG 77.A O no hydrogen 3.368 N/A LEU 81.A N ILE 76.A O no hydrogen 3.004 N/A TYR 83.A OH VAL 169.A O no hydrogen 2.675 N/A VAL 86.A N LEU 84.A O no hydrogen 2.934 N/A LYS 88.A N ASP 108.A OD2 no hydrogen 2.964 N/A LYS 88.A NZ GLN 73.A OE1 no hydrogen 3.162 N/A TYR 89.A N ALA 67.A O no hydrogen 3.056 N/A TYR 89.A OH SER 92.A OG no hydrogen 2.699 N/A TRP 90.A N ILE 106.A O no hydrogen 2.877 N/A TRP 90.A NE1 ASP 108.A OD1 no hydrogen 2.958 N/A SER 92.A OG TYR 89.A OH no hydrogen 2.699 N/A GLY 93.A N PHE 104.A O no hydrogen 3.122 N/A HIS 95.A N TYR 102.A O no hydrogen 2.826 N/A HIS 95.A NE2 GLU 7.A OE1 no hydrogen 2.729 N/A LYS 97.A N LYS 100.A O no hydrogen 3.233 N/A LYS 100.A N LYS 97.A O no hydrogen 3.032 N/A TYR 102.A N HIS 95.A O no hydrogen 2.799 N/A ARG 103.A N GLU 49.A O no hydrogen 2.784 N/A ARG 103.A NH1 SER 51.A O no hydrogen 2.848 N/A PHE 104.A N GLY 93.A O no hydrogen 2.990 N/A MET 105.A N LYS 47.A O no hydrogen 2.934 N/A ILE 106.A N GLY 91.A O no hydrogen 2.699 N/A MET 107.A N VAL 45.A O no hydrogen 2.937 N/A ASP 108.A N LYS 88.A O no hydrogen 3.418 N/A ARG 109.A N PRO 43.A O no hydrogen 3.030 N/A ARG 109.A NE PHE 110.A O no hydrogen 3.011 N/A ARG 109.A NH1 SER 40.A O no hydrogen 3.250 N/A ARG 109.A NH2 SER 40.A O no hydrogen 2.922 N/A ARG 109.A NH2 ALA 42.A O no hydrogen 2.992 N/A GLY 111.A N LEU 161.A O no hydrogen 2.790 N/A SER 112.A OG ASP 113.A O no hydrogen 2.931 N/A LEU 114.A N ALA 156.A O no hydrogen 3.299 N/A LEU 114.A N LEU 159.A O no hydrogen 2.855 N/A GLN 115.A NE2 GLU 119.A OE1 no hydrogen 2.993 N/A LYS 116.A N ASP 113.A OD2 no hydrogen 3.005 N/A TYR 118.A N LEU 114.A O no hydrogen 2.740 N/A TYR 118.A OH LYS 123.A O no hydrogen 3.317 N/A TYR 118.A OH GLN 229.A O no hydrogen 2.736 N/A GLU 119.A N GLN 115.A O no hydrogen 2.944 N/A ALA 120.A N LYS 116.A O no hydrogen 2.983 N/A ASN 121.A N ILE 117.A O no hydrogen 3.073 N/A ASN 121.A N TYR 118.A O no hydrogen 3.123 N/A ASN 121.A ND2 ARG 124.A O no hydrogen 2.647 N/A ALA 122.A N GLU 119.A O no hydrogen 3.085 N/A LYS 123.A N TYR 118.A O no hydrogen 2.865 N/A ARG 124.A NH1 LYS 123.A O no hydrogen 2.905 N/A PHE 125.A N TRP 230.A O no hydrogen 2.925 N/A SER 126.A OG THR 129.A OG1 no hydrogen 2.936 N/A ARG 127.A NE GLU 274.A OE2 no hydrogen 2.835 N/A ARG 127.A NH2 GLU 274.A OE1 no hydrogen 2.666 N/A ARG 127.A NH2 GLU 274.A OE2 no hydrogen 3.510 N/A LYS 128.A NZ GLN 132.A OE1 no hydrogen 2.781 N/A LYS 128.A NZ SER 309.A OG no hydrogen 2.965 N/A LYS 128.A NZ ASP 312.A OD1 no hydrogen 2.769 N/A THR 129.A N SER 126.A OG no hydrogen 3.018 N/A THR 129.A OG1 SER 126.A OG no hydrogen 2.936 N/A THR 129.A OG1 LEU 315.A O no hydrogen 2.650 N/A THR 129.A OG1 ASP 316.A O no hydrogen 3.344 N/A VAL 130.A N SER 126.A O no hydrogen 2.886 N/A LEU 131.A N ARG 127.A O no hydrogen 2.946 N/A GLN 132.A N LYS 128.A O no hydrogen 2.974 N/A GLN 132.A NE2 ASP 311.A OD1 no hydrogen 3.003 N/A LEU 133.A N THR 129.A O no hydrogen 2.751 N/A SER 134.A N VAL 130.A O no hydrogen 2.929 N/A SER 134.A OG VAL 130.A O no hydrogen 2.711 N/A LEU 135.A N LEU 131.A O no hydrogen 2.995 N/A ARG 136.A N GLN 132.A O no hydrogen 3.440 N/A ARG 136.A NE ASP 139.A OD2 no hydrogen 3.105 N/A ARG 136.A NH1 ASP 311.A OD1 no hydrogen 3.101 N/A ARG 136.A NH2 ASP 311.A OD2 no hydrogen 3.173 N/A ILE 137.A N LEU 133.A O no hydrogen 2.908 N/A LEU 138.A N SER 134.A O no hydrogen 2.927 N/A ASP 139.A N LEU 135.A O no hydrogen 3.200 N/A ILE 140.A N ARG 136.A O no hydrogen 3.101 N/A LEU 141.A N ILE 137.A O no hydrogen 2.797 N/A GLU 142.A N LEU 138.A O no hydrogen 2.946 N/A TYR 143.A N ASP 139.A O no hydrogen 3.056 N/A TYR 143.A OH ALA 66.A O no hydrogen 2.456 N/A ILE 144.A N ILE 140.A O no hydrogen 2.933 N/A HIS 145.A N LEU 141.A O no hydrogen 2.836 N/A HIS 145.A ND1 TYR 293.A OH no hydrogen 2.664 N/A HIS 145.A NE2 ASP 219.A OD2 no hydrogen 2.755 N/A GLU 146.A N GLU 142.A O no hydrogen 2.943 N/A HIS 147.A N TYR 143.A O no hydrogen 3.148 N/A HIS 147.A N ILE 144.A O no hydrogen 2.915 N/A HIS 147.A ND1 TYR 143.A O no hydrogen 2.699 N/A GLU 148.A N HIS 145.A O no hydrogen 3.045 N/A TYR 149.A N ILE 144.A O no hydrogen 2.951 N/A VAL 150.A N TYR 178.A O no hydrogen 2.898 N/A HIS 151.A N ASP 219.A OD2 no hydrogen 3.008 N/A HIS 151.A NE2 VAL 172.A O no hydrogen 2.917 N/A GLY 152.A N ASP 219.A OD1 no hydrogen 2.908 N/A ASP 153.A N HIS 151.A ND1 no hydrogen 2.998 N/A LYS 155.A NZ THR 200.A OG1 no hydrogen 2.852 N/A ASN 158.A N LYS 155.A O no hydrogen 2.883 N/A ASN 158.A ND2 ASP 153.A O no hydrogen 2.936 N/A LEU 159.A N ALA 156.A O no hydrogen 3.135 N/A LEU 160.A N TYR 170.A O no hydrogen 2.886 N/A LEU 161.A N SER 112.A O no hydrogen 2.945 N/A ASN 162.A N GLN 168.A O no hydrogen 2.907 N/A ASN 162.A ND2 GLN 168.A OE1 no hydrogen 2.933 N/A LYS 164.A N ASN 162.A OD1 no hydrogen 2.813 N/A ASN 165.A N ASN 162.A O no hydrogen 3.272 N/A ASN 165.A N ASN 162.A OD1 no hydrogen 3.319 N/A ASP 167.A N ASN 165.A OD1 no hydrogen 3.182 N/A GLN 168.A N ASN 165.A O no hydrogen 3.277 N/A VAL 169.A N TYR 83.A OH no hydrogen 2.791 N/A TYR 170.A N LEU 160.A O no hydrogen 2.762 N/A LEU 171.A N GLY 85.A O no hydrogen 2.940 N/A VAL 172.A N ASN 158.A O no hydrogen 2.887 N/A TYR 174.A N GLU 59.A OE2 no hydrogen 2.909 N/A TYR 174.A OH LEU 171.A O no hydrogen 2.857 N/A GLY 175.A N ASP 173.A OD1 no hydrogen 3.198 N/A ALA 177.A N TYR 174.A O no hydrogen 3.040 N/A TYR 178.A N VAL 150.A O no hydrogen 2.970 N/A TYR 178.A OH ASP 192.A OD2 no hydrogen 2.710 N/A ARG 179.A NE GLU 148.A OE1 no hydrogen 3.177 N/A ARG 179.A NH2 GLU 148.A OE1 no hydrogen 3.059 N/A ARG 179.A NH2 GLU 183.A OE2 no hydrogen 3.413 N/A TYR 180.A OH HIS 145.A O no hydrogen 2.616 N/A GLU 183.A N GLU 148.A OE1 no hydrogen 3.473 N/A GLY 184.A N CYS 181.A O no hydrogen 3.086 N/A VAL 185.A N PRO 182.A O no hydrogen 3.147 N/A HIS 186.A ND1 LYS 187.A O no hydrogen 2.721 N/A LYS 187.A N TYR 180.A O no hydrogen 2.957 N/A LYS 194.A N ASP 192.A OD1 no hydrogen 3.151 N/A ARG 195.A N ASP 192.A O no hydrogen 2.957 N/A ARG 195.A NH1 LEU 176.A O no hydrogen 2.836 N/A ARG 195.A NH2 LEU 176.A O no hydrogen 3.510 N/A THR 200.A OG1 ASP 153.A OD1 no hydrogen 2.606 N/A THR 200.A OG1 ASP 153.A OD2 no hydrogen 3.417 N/A GLU 202.A N GLU 202.A OE1 no hydrogen 2.810 N/A PHE 203.A N THR 200.A O no hydrogen 2.845 N/A THR 204.A OG1 ASP 198.A O no hydrogen 2.701 N/A ILE 206.A N GLU 221.A OE2 no hydrogen 2.967 N/A ALA 208.A N SER 205.A OG no hydrogen 2.962 N/A HIS 209.A N SER 205.A O no hydrogen 2.952 N/A ASN 210.A N ILE 206.A O no hydrogen 2.903 N/A GLY 211.A N ALA 208.A O no hydrogen 3.038 N/A VAL 212.A N ASP 207.A O no hydrogen 3.124 N/A ALA 213.A N ALA 190.A O no hydrogen 3.195 N/A SER 215.A OG TYR 287.A O no hydrogen 2.760 N/A ARG 216.A NH2 THR 288.A O no hydrogen 2.939 N/A ARG 217.A NE ASP 207.A OD2 no hydrogen 2.867 N/A ARG 217.A NH1 LEU 285.A O no hydrogen 2.867 N/A ARG 217.A NH2 ASP 207.A OD1 no hydrogen 2.800 N/A ARG 217.A NH2 ASP 207.A OD2 no hydrogen 3.562 N/A LEU 220.A N ARG 216.A O no hydrogen 3.283 N/A GLU 221.A N ARG 217.A O no hydrogen 2.885 N/A ILE 222.A N GLY 218.A O no hydrogen 2.945 N/A LEU 223.A N ASP 219.A O no hydrogen 3.109 N/A GLY 224.A N LEU 220.A O no hydrogen 3.032 N/A TYR 225.A N GLU 221.A O no hydrogen 3.031 N/A TYR 225.A OH GLU 221.A OE2 no hydrogen 2.667 N/A CYS 226.A N ILE 222.A O no hydrogen 2.974 N/A CYS 226.A SG ILE 154.A O no hydrogen 3.375 N/A CYS 226.A SG ILE 222.A O no hydrogen 3.580 N/A MET 227.A N LEU 223.A O no hydrogen 2.822 N/A ILE 228.A N GLY 224.A O no hydrogen 3.201 N/A GLN 229.A N TYR 225.A O no hydrogen 3.038 N/A GLN 229.A NE2 TYR 118.A OH no hydrogen 2.784 N/A TRP 230.A N CYS 226.A O no hydrogen 2.840 N/A LEU 231.A N MET 227.A O no hydrogen 2.937 N/A THR 232.A N ILE 228.A O no hydrogen 2.977 N/A THR 232.A OG1 ILE 228.A O no hydrogen 2.796 N/A GLY 233.A N GLN 229.A O no hydrogen 2.819 N/A HIS 234.A N THR 232.A OG1 no hydrogen 3.069 N/A HIS 234.A ND1 GLU 238.A OE1 no hydrogen 2.559 N/A LEU 235.A N GLU 238.A OE2 no hydrogen 3.253 N/A TRP 237.A NE1 GLU 202.A O no hydrogen 2.922 N/A GLU 238.A N LEU 235.A O no hydrogen 3.189 N/A ASN 240.A N TRP 237.A O no hydrogen 3.098 N/A ASP 243.A N ASN 240.A O no hydrogen 3.094 N/A LYS 245.A N ASP 243.A OD1 no hydrogen 3.164 N/A LYS 245.A NZ ASP 243.A OD1 no hydrogen 2.980 N/A TYR 246.A N ASP 243.A O no hydrogen 3.017 N/A VAL 247.A N ASP 243.A O no hydrogen 3.206 N/A ARG 248.A N PRO 244.A O no hydrogen 2.906 N/A ARG 248.A NH1 ASN 210.A OD1 no hydrogen 2.826 N/A ASP 249.A N LYS 245.A O no hydrogen 2.875 N/A SER 250.A N TYR 246.A O no hydrogen 2.920 N/A LYS 251.A N VAL 247.A O no hydrogen 2.989 N/A LYS 251.A NZ ILE 201.A O no hydrogen 2.848 N/A LYS 251.A NZ THR 204.A O no hydrogen 2.769 N/A LYS 251.A NZ HIS 209.A NE2 no hydrogen 2.942 N/A ILE 252.A N ARG 248.A O no hydrogen 2.884 N/A ARG 253.A N ASP 249.A O no hydrogen 2.969 N/A ARG 253.A NE ASP 249.A OD1 no hydrogen 3.469 N/A ARG 253.A NE ASP 249.A OD2 no hydrogen 3.034 N/A TYR 254.A N SER 250.A O no hydrogen 2.886 N/A ARG 255.A N LYS 251.A O no hydrogen 2.869 N/A GLU 256.A N ILE 252.A O no hydrogen 3.061 N/A ASN 257.A N ARG 253.A O no hydrogen 3.290 N/A SER 260.A OG ASN 257.A O no hydrogen 2.843 N/A LEU 261.A N ASN 257.A O no hydrogen 3.361 N/A MET 262.A N ILE 258.A O no hydrogen 2.936 N/A ASP 263.A N ALA 259.A O no hydrogen 2.884 N/A LYS 264.A N SER 260.A O no hydrogen 2.952 N/A CYS 265.A N LEU 261.A O no hydrogen 2.863 N/A CYS 265.A SG LEU 261.A O no hydrogen 3.268 N/A PHE 266.A N MET 262.A O no hydrogen 2.901 N/A ASN 270.A N PRO 267.A O no hydrogen 2.865 N/A GLU 274.A N GLU 274.A OE1 no hydrogen 2.774 N/A ILE 275.A N PRO 272.A O no hydrogen 3.158 N/A LYS 277.A N GLY 273.A O no hydrogen 2.982 N/A TYR 278.A N GLU 274.A O no hydrogen 2.799 N/A TYR 278.A OH LEU 220.A O no hydrogen 2.742 N/A MET 279.A N ILE 275.A O no hydrogen 2.975 N/A GLU 280.A N ALA 276.A O no hydrogen 2.882 N/A THR 281.A N LYS 277.A O no hydrogen 2.967 N/A THR 281.A OG1 LYS 277.A O no hydrogen 2.745 N/A VAL 282.A N TYR 278.A O no hydrogen 3.039 N/A LYS 283.A N MET 279.A O no hydrogen 2.999 N/A LYS 283.A NZ ARG 255.A O no hydrogen 2.888 N/A LYS 283.A NZ GLU 256.A O no hydrogen 3.144 N/A LEU 284.A N THR 281.A O no hydrogen 3.132 N/A LEU 285.A N VAL 282.A O no hydrogen 3.011 N/A ASP 286.A N GLU 289.A OE1 no hydrogen 2.917 N/A TYR 287.A OH ALA 213.A O no hydrogen 2.438 N/A GLU 289.A N ASP 286.A O no hydrogen 3.149 N/A LYS 290.A NZ GLU 146.A OE2 no hydrogen 3.342 N/A TYR 293.A OH HIS 145.A ND1 no hydrogen 2.664 N/A LEU 296.A N LEU 292.A O no hydrogen 3.199 N/A ARG 297.A N TYR 293.A O no hydrogen 2.931 N/A ARG 297.A NE GLU 294.A OE1 no hydrogen 3.157 N/A ARG 297.A NH1 GLU 142.A OE1 no hydrogen 3.018 N/A ARG 297.A NH2 GLU 142.A OE1 no hydrogen 2.823 N/A ARG 297.A NH2 GLU 294.A OE1 no hydrogen 2.764 N/A ASP 298.A N GLU 294.A O no hydrogen 2.784 N/A ILE 299.A N ASN 295.A O no hydrogen 2.948 N/A LEU 300.A N LEU 296.A O no hydrogen 3.304 N/A LEU 301.A N ARG 297.A O no hydrogen 2.909 N/A GLN 302.A N ASP 298.A O no hydrogen 3.145 N/A LEU 304.A N LEU 300.A O no hydrogen 3.276 N/A LYS 305.A N LEU 301.A O no hydrogen 3.066 N/A ALA 306.A N GLN 302.A O no hydrogen 2.927 N/A ILE 307.A N LEU 304.A O no hydrogen 3.178 N/A GLY 308.A N LYS 305.A O no hydrogen 2.833 N/A SER 309.A N LEU 304.A O no hydrogen 2.840 N/A SER 309.A OG LYS 310.A O no hydrogen 3.428 N/A ASP 312.A N LYS 310.A O no hydrogen 2.907 N/A LYS 314.A N ASP 312.A OD1 no hydrogen 3.121 N/A LEU 315.A N ASP 167.A OD1 no hydrogen 2.953 N/A