Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6qyq_C.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 5.A NE2 ARG 243.A O no hydrogen 2.572 N/A GLU 7.A N HIS 5.A ND1 no hydrogen 3.185 N/A LEU 8.A N HIS 5.A O no hydrogen 3.134 N/A GLN 9.A N GLY 6.A O no hydrogen 2.685 N/A GLN 9.A NE2 GLY 6.A O no hydrogen 3.345 N/A GLN 9.A NE2 ARG 36.A O no hydrogen 2.729 N/A TYR 10.A OH MET 188.A O no hydrogen 2.716 N/A LEU 11.A N GLU 7.A O no hydrogen 3.096 N/A GLY 12.A N LEU 8.A O no hydrogen 2.989 N/A GLN 13.A N GLN 9.A O no hydrogen 2.812 N/A ILE 14.A N TYR 10.A O no hydrogen 2.951 N/A GLN 15.A N LEU 11.A O no hydrogen 2.985 N/A HIS 16.A N GLY 12.A O no hydrogen 3.036 N/A ILE 17.A N GLN 13.A O no hydrogen 3.084 N/A LEU 18.A N ILE 14.A O no hydrogen 2.938 N/A ARG 19.A N GLN 15.A O no hydrogen 2.826 N/A VAL 21.A N SER 29.A O no hydrogen 2.919 N/A LYS 23.A N THR 27.A O no hydrogen 3.124 N/A THR 27.A N LYS 23.A O no hydrogen 3.348 N/A LEU 28.A N ILE 226.A O no hydrogen 2.957 N/A SER 29.A OG ASP 223.A OD1 no hydrogen 3.552 N/A VAL 30.A N ALA 224.A O no hydrogen 3.063 N/A GLY 32.A N GLY 222.A O no hydrogen 2.874 N/A MET 33.A N LEU 221.A O no hydrogen 3.161 N/A GLN 34.A NE2 THR 220.A OG1 no hydrogen 3.023 N/A ALA 35.A N HIS 219.A O no hydrogen 2.979 N/A ARG 36.A N GLN 9.A OE1 no hydrogen 2.860 N/A ARG 36.A NH2 ASP 216.A OD2 no hydrogen 3.155 N/A TYR 37.A N PHE 217.A O no hydrogen 2.726 N/A LEU 39.A N GLY 215.A O no hydrogen 2.824 N/A ARG 40.A N SER 38.A OG no hydrogen 3.034 N/A ARG 40.A NE GLU 176.A OE1 no hydrogen 2.922 N/A ARG 40.A NH1 SER 38.A OG no hydrogen 3.150 N/A ARG 40.A NH1 ASP 216.A OD1 no hydrogen 2.833 N/A ARG 40.A NH2 GLU 176.A OE1 no hydrogen 3.454 N/A ARG 40.A NH2 ASP 216.A OD2 no hydrogen 2.984 N/A PHE 43.A N PRO 246.A O no hydrogen 2.720 N/A LEU 45.A N PHE 43.A O no hydrogen 2.668 N/A THR 47.A N GLU 7.A OE1 no hydrogen 3.005 N/A THR 47.A N GLU 7.A OE2 no hydrogen 2.992 N/A THR 47.A OG1 GLU 7.A OE2 no hydrogen 2.976 N/A THR 47.A OG1 ARG 243.A O no hydrogen 3.222 N/A THR 48.A N GLU 7.A OE1 no hydrogen 2.833 N/A THR 48.A OG1 GLU 7.A OE1 no hydrogen 2.718 N/A LYS 49.A NZ GLY 189.A O no hydrogen 2.801 N/A VAL 51.A N TYR 270.A OH no hydrogen 3.057 N/A LYS 54.A NZ LYS 76.A O no hydrogen 3.360 N/A VAL 56.A N PHE 52.A O no hydrogen 3.026 N/A LEU 57.A N TRP 53.A O no hydrogen 2.963 N/A GLU 58.A N LYS 54.A O no hydrogen 2.853 N/A GLU 59.A N GLY 55.A O no hydrogen 2.972 N/A LEU 60.A N VAL 56.A O no hydrogen 3.115 N/A LEU 61.A N LEU 57.A O no hydrogen 3.171 N/A TRP 62.A N GLU 58.A O no hydrogen 2.985 N/A TRP 62.A NE1 ASN 69.A O no hydrogen 3.011 N/A PHE 63.A N GLU 59.A O no hydrogen 2.846 N/A ILE 64.A N LEU 60.A O no hydrogen 2.780 N/A LYS 65.A N LEU 61.A O no hydrogen 2.852 N/A GLY 66.A N PHE 63.A O no hydrogen 2.813 N/A SER 67.A N TRP 62.A O no hydrogen 3.391 N/A SER 67.A OG GLU 72.A OE1 no hydrogen 3.191 N/A THR 68.A OG1 TYR 118.A OH no hydrogen 2.879 N/A ASN 69.A N SER 67.A OG no hydrogen 3.197 N/A ALA 70.A N GLY 101.A O no hydrogen 2.936 N/A LYS 71.A N ASN 69.A OD1 no hydrogen 2.798 N/A GLU 72.A N ASN 69.A O no hydrogen 2.969 N/A LEU 73.A N ALA 70.A O no hydrogen 2.986 N/A SER 74.A N ALA 70.A O no hydrogen 2.916 N/A SER 74.A OG ASP 82.A OD1 no hydrogen 3.387 N/A SER 74.A OG ASP 82.A OD2 no hydrogen 2.620 N/A SER 75.A N LYS 71.A O no hydrogen 3.095 N/A SER 75.A OG LYS 71.A O no hydrogen 3.449 N/A SER 75.A OG GLU 72.A O no hydrogen 3.307 N/A LYS 76.A N LEU 73.A O no hydrogen 2.883 N/A GLY 77.A N SER 74.A O no hydrogen 2.613 N/A TRP 81.A NE1 GLU 59.A OE2 no hydrogen 2.702 N/A ASP 82.A N LYS 79.A O no hydrogen 2.986 N/A ASN 84.A N TRP 81.A O no hydrogen 3.036 N/A GLY 85.A N ASP 82.A O no hydrogen 3.007 N/A SER 86.A OG ALA 83.A O no hydrogen 3.405 N/A ARG 87.A N GLU 100.A OE1 no hydrogen 2.931 N/A ARG 87.A NE ARG 87.A O no hydrogen 3.170 N/A ARG 87.A NE ASP 91.A OD1 no hydrogen 2.897 N/A ARG 87.A NE ASP 91.A OD2 no hydrogen 3.271 N/A ARG 87.A NH1 ARG 98.A O no hydrogen 3.096 N/A ARG 87.A NH2 ASP 91.A OD1 no hydrogen 2.835 N/A ARG 87.A NH2 ARG 98.A O no hydrogen 3.080 N/A LEU 90.A N SER 86.A O no hydrogen 2.889 N/A ASP 91.A N ARG 87.A O no hydrogen 2.721 N/A SER 92.A N ASP 88.A O no hydrogen 2.572 N/A LEU 93.A N LEU 90.A O no hydrogen 2.941 N/A GLY 94.A N ASP 91.A O no hydrogen 3.119 N/A PHE 95.A N LEU 90.A O no hydrogen 2.942 N/A ARG 98.A N PHE 95.A O no hydrogen 3.343 N/A ARG 98.A NH1 LEU 160.A O no hydrogen 2.997 N/A ARG 98.A NH2 ASP 102.A O no hydrogen 3.451 N/A ARG 98.A NH2 LEU 160.A O no hydrogen 3.001 N/A GLY 101.A N GLY 85.A O no hydrogen 2.981 N/A ASP 102.A N GLU 99.A O no hydrogen 3.267 N/A LEU 103.A N THR 68.A O no hydrogen 3.071 N/A GLY 104.A N ASP 102.A OD1 no hydrogen 3.028 N/A VAL 106.A N GLY 104.A O no hydrogen 2.838 N/A GLN 110.A N VAL 106.A O no hydrogen 2.990 N/A GLN 110.A NE2 PRO 105.A O no hydrogen 3.160 N/A GLN 110.A NE2 ASP 157.A OD2 no hydrogen 2.957 N/A TRP 111.A N TYR 107.A O no hydrogen 2.826 N/A ARG 112.A N GLY 108.A O no hydrogen 3.224 N/A ARG 112.A NE ASP 131.A OD1 no hydrogen 2.647 N/A ARG 112.A NH1 ILE 64.A O no hydrogen 2.895 N/A ARG 112.A NH1 ASP 258.A OD2 no hydrogen 3.394 N/A ARG 112.A NH2 ASP 131.A OD1 no hydrogen 3.168 N/A ARG 112.A NH2 ASP 131.A OD2 no hydrogen 2.640 N/A HIS 113.A N PHE 109.A O no hydrogen 2.712 N/A HIS 113.A ND1 GLN 128.A O no hydrogen 2.848 N/A PHE 114.A N VAL 130.A O no hydrogen 2.944 N/A ALA 116.A N HIS 113.A O no hydrogen 3.071 N/A TYR 118.A OH THR 68.A OG1 no hydrogen 2.879 N/A TYR 118.A OH ASP 102.A OD1 no hydrogen 2.633 N/A ARG 119.A N TYR 125.A OH no hydrogen 2.970 N/A ARG 119.A NH1 ASP 124.A O no hydrogen 3.507 N/A ARG 119.A NH2 GLN 128.A OE1 no hydrogen 2.329 N/A MET 121.A N ASP 102.A OD2 no hydrogen 3.298 N/A GLU 122.A N ASP 120.A OD1 no hydrogen 2.636 N/A SER 123.A N ASP 120.A O no hydrogen 3.348 N/A SER 123.A N ASP 120.A OD1 no hydrogen 3.141 N/A TYR 125.A OH ASP 120.A O no hydrogen 2.762 N/A SER 126.A N ASP 124.A OD1 no hydrogen 3.016 N/A SER 126.A OG ASP 124.A OD1 no hydrogen 2.562 N/A GLN 128.A N TYR 125.A O no hydrogen 2.673 N/A VAL 130.A N PHE 114.A O no hydrogen 2.804 N/A GLN 132.A NE2 GLN 110.A O no hydrogen 2.764 N/A LEU 133.A N TRP 111.A O no hydrogen 3.277 N/A GLN 134.A N ASP 131.A OD1 no hydrogen 3.166 N/A GLN 134.A NE2 GLN 134.A O no hydrogen 3.279 N/A GLN 134.A NE2 ASP 138.A OD1 no hydrogen 2.759 N/A ARG 135.A N ASP 131.A O no hydrogen 3.079 N/A VAL 136.A N GLN 132.A O no hydrogen 2.802 N/A ILE 137.A N LEU 133.A O no hydrogen 3.009 N/A ASP 138.A N GLN 134.A O no hydrogen 2.837 N/A THR 139.A N ARG 135.A O no hydrogen 2.932 N/A THR 139.A OG1 ARG 135.A O no hydrogen 3.183 N/A ILE 140.A N VAL 136.A O no hydrogen 2.973 N/A LYS 141.A N ILE 137.A O no hydrogen 3.181 N/A THR 142.A N THR 139.A O no hydrogen 3.163 N/A THR 142.A OG1 ASP 138.A O no hydrogen 3.088 N/A ASN 143.A N THR 139.A O no hydrogen 2.713 N/A ASP 146.A N ASN 143.A O no hydrogen 3.046 N/A CYS 147.A SG ASP 145.A O no hydrogen 3.651 N/A ARG 148.A N ASP 146.A OD1 no hydrogen 2.470 N/A TRP 153.A N ALA 167.A O no hydrogen 3.204 N/A ASN 154.A ND2 GLN 110.A OE1 no hydrogen 3.688 N/A ARG 156.A N ASN 154.A OD1 no hydrogen 3.225 N/A ARG 156.A NE ASP 157.A OD1 no hydrogen 2.991 N/A ARG 156.A NH1 GLY 115.A O no hydrogen 2.965 N/A ARG 156.A NH2 ALA 116.A O no hydrogen 2.813 N/A ARG 156.A NH2 ASP 157.A OD2 no hydrogen 3.127 N/A ASP 157.A N ASN 154.A O no hydrogen 2.865 N/A LEU 158.A N PRO 155.A O no hydrogen 3.396 N/A LEU 160.A N ASP 157.A O no hydrogen 2.986 N/A MET 161.A N LEU 158.A O no hydrogen 2.923 N/A ALA 162.A N LEU 103.A O no hydrogen 2.684 N/A ALA 167.A N TYR 182.A O no hydrogen 2.930 N/A PHE 170.A N ILE 149.A O no hydrogen 2.943 N/A TYR 171.A N SER 178.A O no hydrogen 3.046 N/A VAL 173.A N GLU 176.A O no hydrogen 3.072 N/A GLU 176.A N VAL 173.A O no hydrogen 2.707 N/A LEU 177.A N LYS 213.A O no hydrogen 2.863 N/A SER 178.A N TYR 171.A O no hydrogen 2.833 N/A CYS 179.A N ASP 216.A O no hydrogen 3.135 N/A GLN 180.A N GLN 169.A O no hydrogen 2.793 N/A LEU 181.A N ILE 218.A O no hydrogen 2.989 N/A TYR 182.A N LEU 168.A O no hydrogen 2.828 N/A GLN 183.A N THR 220.A O no hydrogen 2.889 N/A GLN 183.A NE2 SER 185.A O no hydrogen 3.052 N/A GLN 183.A NE2 ASN 195.A OD1 no hydrogen 2.817 N/A ARG 184.A NE PRO 165.A O no hydrogen 2.878 N/A ARG 184.A NH2 PRO 165.A O no hydrogen 3.358 N/A SER 185.A OG HIS 225.A NE2 no hydrogen 3.068 N/A GLY 186.A N ASP 223.A O no hydrogen 2.914 N/A MET 188.A N HIS 225.A O no hydrogen 2.863 N/A LEU 190.A N ASP 187.A OD1 no hydrogen 3.168 N/A GLY 191.A N ASP 187.A O no hydrogen 2.909 N/A VAL 192.A N ASP 187.A O no hydrogen 3.016 N/A ASN 195.A N GLY 191.A O no hydrogen 2.687 N/A ILE 196.A N VAL 192.A O no hydrogen 2.762 N/A ALA 197.A N PRO 193.A O no hydrogen 3.259 N/A SER 198.A N PHE 194.A O no hydrogen 3.070 N/A TYR 199.A N ASN 195.A O no hydrogen 3.266 N/A ALA 200.A N ILE 196.A O no hydrogen 2.975 N/A LEU 201.A N ALA 197.A O no hydrogen 2.791 N/A LEU 202.A N SER 198.A O no hydrogen 3.007 N/A THR 203.A N TYR 199.A O no hydrogen 2.963 N/A THR 203.A OG1 TYR 199.A O no hydrogen 2.780 N/A TYR 204.A N ALA 200.A O no hydrogen 2.951 N/A TYR 204.A OH LEU 39.A O no hydrogen 2.916 N/A TYR 204.A OH GLU 42.A O no hydrogen 2.865 N/A MET 205.A N LEU 201.A O no hydrogen 2.925 N/A ILE 206.A N LEU 202.A O no hydrogen 2.925 N/A ALA 207.A N THR 203.A O no hydrogen 2.810 N/A HIS 208.A N TYR 204.A O no hydrogen 3.037 N/A ILE 209.A N MET 205.A O no hydrogen 3.023 N/A THR 210.A N ILE 206.A O no hydrogen 2.821 N/A THR 210.A OG1 ILE 206.A O no hydrogen 2.834 N/A THR 210.A OG1 ALA 207.A O no hydrogen 3.006 N/A GLY 211.A N HIS 208.A O no hydrogen 3.221 N/A LEU 212.A N ALA 207.A O no hydrogen 2.780 N/A LYS 213.A N SER 175.A O no hydrogen 2.982 N/A GLY 215.A N LEU 177.A O no hydrogen 2.625 N/A ASP 216.A N SER 178.A OG no hydrogen 2.982 N/A PHE 217.A N TYR 37.A O no hydrogen 2.761 N/A ILE 218.A N CYS 179.A O no hydrogen 2.961 N/A HIS 219.A N ALA 35.A O no hydrogen 2.824 N/A HIS 219.A NE2 GLN 183.A OE1 no hydrogen 2.676 N/A THR 220.A N LEU 181.A O no hydrogen 2.961 N/A THR 220.A OG1 GLN 180.A OE1 no hydrogen 2.617 N/A LEU 221.A N MET 33.A O no hydrogen 3.017 N/A GLY 222.A N GLN 183.A O no hydrogen 2.779 N/A ASP 223.A N ARG 184.A O no hydrogen 2.961 N/A ALA 224.A N VAL 30.A O no hydrogen 2.899 N/A HIS 225.A N GLY 186.A O no hydrogen 3.204 N/A HIS 225.A NE2 SER 185.A OG no hydrogen 3.068 N/A ILE 226.A N LEU 28.A O no hydrogen 2.794 N/A LEU 228.A N GLY 26.A O no hydrogen 3.176 N/A HIS 230.A N TYR 227.A O no hydrogen 2.935 N/A HIS 230.A NE2 GLU 279.A O no hydrogen 2.803 N/A ILE 231.A N LEU 228.A O no hydrogen 3.223 N/A LEU 234.A N HIS 230.A O no hydrogen 2.839 N/A LYS 235.A N ILE 231.A O no hydrogen 2.718 N/A ILE 236.A N GLU 232.A O no hydrogen 3.171 N/A GLN 237.A N PRO 233.A O no hydrogen 2.894 N/A GLN 237.A NE2 THR 48.A OG1 no hydrogen 2.632 N/A LEU 238.A N LEU 234.A O no hydrogen 2.799 N/A GLN 239.A N ILE 236.A O no hydrogen 3.006 N/A ARG 240.A N GLN 237.A O no hydrogen 3.111 N/A ARG 240.A NH1 THR 48.A O no hydrogen 2.873 N/A ARG 240.A NH1 PRO 274.A O no hydrogen 2.889 N/A ARG 243.A N THR 47.A OG1 no hydrogen 3.057 N/A ARG 243.A NH1 ASN 271.A O no hydrogen 3.182 N/A LYS 247.A N GLU 268.A O no hydrogen 3.167 N/A LYS 247.A NZ ASP 41.A OD2 no hydrogen 2.728 N/A ARG 249.A N GLN 266.A O no hydrogen 2.923 N/A ARG 249.A NH2 GLU 268.A OE2 no hydrogen 3.113 N/A LEU 251.A N ASP 264.A O no hydrogen 2.890 N/A ARG 252.A NE ASP 264.A OD1 no hydrogen 2.813 N/A ARG 252.A NH2 ASP 259.A O no hydrogen 3.203 N/A ARG 252.A NH2 ASP 264.A OD1 no hydrogen 3.501 N/A ARG 252.A NH2 ASP 264.A OD2 no hydrogen 2.882 N/A VAL 254.A N HIS 208.A NE2 no hydrogen 3.028 N/A ASP 259.A N LYS 256.A O no hydrogen 2.844 N/A PHE 260.A N ILE 257.A O no hydrogen 3.375 N/A LYS 261.A N ASP 264.A OD2 no hydrogen 2.852 N/A ASP 264.A N LYS 261.A O no hydrogen 2.982 N/A PHE 265.A N ALA 262.A O no hydrogen 3.235 N/A GLN 266.A N ARG 249.A O no hydrogen 2.851 N/A GLU 268.A N LYS 247.A O no hydrogen 2.792 N/A TYR 270.A OH LEU 46.A O no hydrogen 2.514 N/A HIS 273.A N THR 47.A O no hydrogen 2.724 N/A HIS 273.A NE2 GLU 241.A O no hydrogen 2.615 N/A