Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6tia_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 4.A N LEU 84.A O no hydrogen 3.157 N/A PHE 6.A N PHE 86.A O no hydrogen 2.853 N/A TYR 9.A N SER 7.A OG no hydrogen 3.388 N/A GLU 10.A N SER 7.A O no hydrogen 3.052 N/A LYS 12.A N PHE 8.A O no hydrogen 2.842 N/A THR 15.A N LEU 11.A O no hydrogen 3.313 N/A THR 15.A OG1 LEU 11.A O no hydrogen 2.916 N/A ASN 16.A ND2 ASP 19.A OD2 no hydrogen 3.164 N/A ASN 17.A N LYS 12.A O no hydrogen 2.709 N/A PHE 18.A N THR 15.A OG1 no hydrogen 3.362 N/A ASP 19.A N THR 15.A O no hydrogen 3.437 N/A GLY 26.A N PRO 22.A O no hydrogen 3.080 N/A GLY 27.A N PRO 22.A O no hydrogen 2.791 N/A ASN 28.A N ASP 19.A O no hydrogen 3.033 N/A ASN 28.A ND2 LYS 40.A O no hydrogen 2.866 N/A LYS 29.A N ASP 19.A O no hydrogen 2.969 N/A LYS 29.A N ARG 21.A O no hydrogen 3.208 N/A MET 30.A N VAL 38.A O no hydrogen 3.010 N/A GLY 33.A N GLY 36.A O no hydrogen 3.011 N/A VAL 37.A N LYS 52.A O no hydrogen 3.035 N/A VAL 38.A N GLY 31.A O no hydrogen 3.026 N/A TYR 39.A N VAL 50.A O no hydrogen 2.722 N/A LYS 40.A N ASN 28.A O no hydrogen 2.761 N/A LYS 40.A NZ TYR 42.A OH no hydrogen 3.410 N/A GLY 41.A N VAL 48.A O no hydrogen 2.821 N/A VAL 43.A N THR 46.A O no hydrogen 2.981 N/A THR 46.A N VAL 43.A O no hydrogen 3.255 N/A THR 46.A OG1 VAL 43.A O no hydrogen 2.724 N/A VAL 48.A N GLY 41.A O no hydrogen 2.709 N/A ALA 49.A N TYR 97.A O no hydrogen 2.845 N/A VAL 50.A N TYR 39.A O no hydrogen 2.740 N/A LYS 51.A N LEU 95.A O no hydrogen 2.737 N/A LYS 51.A NZ GLY 34.A O no hydrogen 3.046 N/A LYS 52.A N VAL 37.A O no hydrogen 2.895 N/A LEU 53.A N LEU 93.A O no hydrogen 2.855 N/A LEU 61.A N THR 57.A O no hydrogen 2.952 N/A LYS 62.A N THR 58.A O no hydrogen 3.161 N/A GLN 63.A N GLU 59.A O no hydrogen 3.325 N/A GLN 64.A N GLU 60.A O no hydrogen 3.259 N/A PHE 65.A N LEU 61.A O no hydrogen 3.013 N/A ASP 66.A N LYS 62.A O no hydrogen 3.022 N/A GLN 67.A N GLN 63.A O no hydrogen 2.782 N/A GLU 68.A N GLN 64.A O no hydrogen 2.876 N/A ILE 69.A N PHE 65.A O no hydrogen 3.309 N/A LYS 70.A N ASP 66.A O no hydrogen 2.957 N/A VAL 71.A N GLN 67.A O no hydrogen 2.934 N/A MET 72.A N GLU 68.A O no hydrogen 2.923 N/A ALA 73.A N ILE 69.A O no hydrogen 2.827 N/A LYS 74.A N LYS 70.A O no hydrogen 3.346 N/A CYS 75.A N VAL 71.A O no hydrogen 2.759 N/A CYS 75.A SG VAL 71.A O no hydrogen 3.366 N/A GLN 76.A NE2 GLU 82.A OE1 no hydrogen 3.209 N/A ASN 79.A N HIS 77.A ND1 no hydrogen 2.901 N/A ASN 79.A ND2 ALA 160.A O no hydrogen 2.819 N/A LEU 80.A N HIS 77.A O no hydrogen 3.130 N/A VAL 81.A N ILE 162.A O no hydrogen 2.865 N/A LEU 84.A N VAL 96.A O no hydrogen 2.764 N/A GLY 85.A N VAL 96.A O no hydrogen 3.333 N/A PHE 86.A N HIS 4.A O no hydrogen 3.184 N/A SER 87.A N CYS 94.A O no hydrogen 2.890 N/A CYS 94.A N SER 87.A O no hydrogen 3.243 N/A LEU 95.A N LYS 51.A O no hydrogen 2.923 N/A VAL 96.A N GLY 85.A O no hydrogen 2.844 N/A TYR 97.A N ALA 49.A O no hydrogen 2.773 N/A TYR 99.A N THR 47.A O no hydrogen 3.183 N/A ASN 102.A N LEU 154.A O no hydrogen 3.220 N/A ASN 102.A ND2 ASP 155.A O no hydrogen 2.955 N/A GLY 103.A N MET 100.A O no hydrogen 3.078 N/A LEU 105.A N ILE 152.A O no hydrogen 2.785 N/A LEU 106.A N SER 149.A O no hydrogen 3.188 N/A ARG 108.A N SER 104.A O no hydrogen 3.118 N/A ARG 108.A NE THR 115.A OG1 no hydrogen 2.911 N/A ARG 108.A NH1 LEU 112.A O no hydrogen 2.947 N/A ARG 108.A NH2 ASN 102.A O no hydrogen 2.776 N/A LEU 109.A N LEU 105.A O no hydrogen 2.973 N/A SER 110.A N LEU 106.A O no hydrogen 3.233 N/A SER 110.A OG LEU 106.A O no hydrogen 3.178 N/A SER 110.A OG ASP 107.A O no hydrogen 3.199 N/A CYS 111.A SG ARG 108.A O no hydrogen 3.877 N/A LEU 112.A N ASP 107.A O no hydrogen 2.991 N/A GLY 114.A N CYS 111.A O no hydrogen 3.253 N/A THR 115.A OG1 LEU 112.A O no hydrogen 3.491 N/A TRP 120.A N ASP 247.A OD1 no hydrogen 2.847 N/A TRP 120.A NE1 SER 252.A OG no hydrogen 2.827 N/A HIS 121.A N ASP 247.A OD2 no hydrogen 3.026 N/A MET 122.A N SER 119.A OG no hydrogen 3.114 N/A ARG 123.A N SER 119.A O no hydrogen 2.952 N/A ARG 123.A NE LEU 118.A O no hydrogen 2.859 N/A ARG 123.A NH1 ILE 207.A O no hydrogen 2.804 N/A ARG 123.A NH1 ASP 242.A OD2 no hydrogen 2.819 N/A ARG 123.A NH2 LEU 118.A O no hydrogen 2.977 N/A ARG 123.A NH2 ASP 242.A OD2 no hydrogen 2.916 N/A CYS 124.A N TRP 120.A O no hydrogen 3.033 N/A CYS 124.A SG TRP 120.A O no hydrogen 3.340 N/A LYS 125.A N HIS 121.A O no hydrogen 3.351 N/A ILE 126.A N MET 122.A O no hydrogen 3.018 N/A ALA 127.A N ARG 123.A O no hydrogen 3.065 N/A GLN 128.A N CYS 124.A O no hydrogen 3.014 N/A GLY 129.A N LYS 125.A O no hydrogen 2.889 N/A ALA 130.A N ILE 126.A O no hydrogen 2.952 N/A ALA 131.A N ALA 127.A O no hydrogen 3.007 N/A ASN 132.A N GLN 128.A O no hydrogen 3.005 N/A ASN 132.A ND2 ASN 79.A OD1 no hydrogen 3.555 N/A GLY 133.A N GLY 129.A O no hydrogen 3.112 N/A ILE 134.A N ALA 130.A O no hydrogen 3.001 N/A ASN 135.A N ALA 131.A O no hydrogen 2.912 N/A PHE 136.A N ASN 132.A O no hydrogen 3.082 N/A LEU 137.A N GLY 133.A O no hydrogen 3.344 N/A HIS 138.A N ILE 134.A O no hydrogen 2.887 N/A HIS 138.A NE2 ASP 196.A OD2 no hydrogen 2.917 N/A GLU 139.A N ASN 135.A O no hydrogen 2.890 N/A ASN 140.A N PHE 136.A O no hydrogen 3.048 N/A HIS 141.A N HIS 138.A O no hydrogen 3.331 N/A HIS 142.A N LEU 137.A O no hydrogen 2.751 N/A HIS 142.A ND1 ASN 140.A O no hydrogen 2.948 N/A ILE 143.A N ARG 169.A O no hydrogen 2.803 N/A HIS 144.A N ASP 196.A OD2 no hydrogen 2.876 N/A HIS 144.A NE2 SER 163.A O no hydrogen 2.786 N/A ARG 145.A N ASP 196.A OD1 no hydrogen 3.052 N/A ARG 145.A NE LEU 167.A O no hydrogen 2.787 N/A ARG 145.A NH2 LEU 167.A O no hydrogen 3.158 N/A ASP 146.A N HIS 144.A ND1 no hydrogen 2.933 N/A LYS 148.A NZ THR 178.A OG1 no hydrogen 3.086 N/A SER 149.A OG TYR 181.A OH no hydrogen 3.346 N/A SER 149.A OG GLU 206.A OE1 no hydrogen 3.488 N/A SER 149.A OG GLU 206.A OE2 no hydrogen 2.661 N/A ASN 151.A N LYS 148.A O no hydrogen 2.922 N/A ASN 151.A ND2 ASP 146.A O no hydrogen 2.733 N/A ILE 152.A N SER 149.A O no hydrogen 3.429 N/A LEU 153.A N LYS 161.A O no hydrogen 2.854 N/A LEU 154.A N GLY 103.A O no hydrogen 2.895 N/A ASP 155.A N THR 159.A O no hydrogen 3.318 N/A ALA 157.A N ASP 155.A OD1 no hydrogen 3.159 N/A PHE 158.A N ASP 155.A O no hydrogen 2.800 N/A THR 159.A N ASP 155.A OD1 no hydrogen 2.774 N/A LYS 161.A N LEU 153.A O no hydrogen 2.784 N/A ILE 162.A N ASN 79.A O no hydrogen 3.044 N/A SER 163.A N ASN 151.A O no hydrogen 2.772 N/A SER 163.A OG ASN 151.A O no hydrogen 3.204 N/A PHE 165.A N GLU 68.A OE1 no hydrogen 3.134 N/A PHE 165.A N GLU 68.A OE2 no hydrogen 3.213 N/A ALA 168.A N PHE 165.A O no hydrogen 3.174 N/A ARG 169.A N ILE 143.A O no hydrogen 2.827 N/A THR 178.A OG1 ASP 146.A OD1 no hydrogen 2.689 N/A TYR 181.A N THR 178.A O no hydrogen 2.988 N/A TYR 181.A OH SER 149.A OG no hydrogen 3.346 N/A TYR 181.A OH GLU 206.A OE1 no hydrogen 2.657 N/A TYR 181.A OH GLU 206.A OE2 no hydrogen 3.220 N/A MET 182.A N THR 179.A O no hydrogen 3.333 N/A GLU 185.A N GLU 185.A OE1 no hydrogen 2.923 N/A ALA 186.A N ALA 183.A O no hydrogen 2.961 N/A LEU 187.A N ALA 183.A O no hydrogen 3.189 N/A ARG 188.A N GLU 185.A O no hydrogen 3.122 N/A GLY 189.A N ALA 186.A O no hydrogen 3.255 N/A GLU 190.A N GLU 185.A O no hydrogen 3.000 N/A ILE 191.A N VAL 172.A O no hydrogen 3.074 N/A LYS 194.A NZ THR 192.A OG1 no hydrogen 2.957 N/A SER 195.A N THR 192.A O no hydrogen 3.066 N/A SER 195.A OG GLU 185.A OE2 no hydrogen 3.019 N/A SER 195.A OG THR 192.A O no hydrogen 3.477 N/A SER 199.A N SER 195.A O no hydrogen 3.120 N/A SER 199.A OG TYR 181.A O no hydrogen 2.742 N/A SER 199.A OG SER 195.A O no hydrogen 3.350 N/A PHE 200.A N ASP 196.A O no hydrogen 3.052 N/A GLY 201.A N ILE 197.A O no hydrogen 3.005 N/A VAL 202.A N TYR 198.A O no hydrogen 3.344 N/A VAL 203.A N SER 199.A O no hydrogen 3.259 N/A LEU 204.A N PHE 200.A O no hydrogen 2.981 N/A LEU 205.A N GLY 201.A O no hydrogen 3.257 N/A GLU 206.A N VAL 202.A O no hydrogen 3.000 N/A ILE 207.A N VAL 203.A O no hydrogen 3.129 N/A ILE 208.A N LEU 204.A O no hydrogen 3.102 N/A THR 209.A N LEU 205.A O no hydrogen 3.034 N/A THR 209.A OG1 LEU 205.A O no hydrogen 2.630 N/A GLY 210.A N GLU 206.A O no hydrogen 2.768 N/A LEU 211.A N THR 209.A OG1 no hydrogen 3.163 N/A ASP 215.A N GLN 221.A O no hydrogen 2.984 N/A ARG 218.A NE PRO 220.A O no hydrogen 2.857 N/A ARG 218.A NH1 PRO 212.A O no hydrogen 2.830 N/A ARG 218.A NH2 PRO 212.A O no hydrogen 2.931 N/A ARG 218.A NH2 GLN 221.A O no hydrogen 2.911 N/A GLN 221.A NE2 GLU 216.A O no hydrogen 3.132 N/A LEU 223.A N ALA 213.A O no hydrogen 2.846 N/A ASP 225.A N LEU 222.A O no hydrogen 3.032 N/A ILE 226.A N LEU 223.A O no hydrogen 3.104 N/A LYS 227.A NZ GLU 231.A OE1 no hydrogen 3.165 N/A LYS 227.A NZ GLU 266.A OE2 no hydrogen 3.530 N/A GLU 228.A N ASP 225.A O no hydrogen 3.084 N/A GLU 229.A N ASP 225.A O no hydrogen 3.408 N/A ILE 230.A N ILE 226.A O no hydrogen 3.048 N/A GLU 231.A N LYS 227.A O no hydrogen 3.081 N/A ASP 232.A N GLU 228.A O no hydrogen 2.850 N/A GLU 233.A N ILE 230.A O no hydrogen 2.930 N/A GLU 234.A N GLU 229.A O no hydrogen 2.809 N/A LYS 235.A N GLU 229.A O no hydrogen 3.152 N/A THR 236.A N ASP 239.A OD2 no hydrogen 2.849 N/A ASP 239.A N THR 236.A OG1 no hydrogen 3.384 N/A TYR 240.A N ILE 237.A O no hydrogen 2.915 N/A TYR 240.A OH GLU 229.A OE2 no hydrogen 2.658 N/A ILE 241.A N ILE 237.A O no hydrogen 3.008 N/A ASP 242.A N ILE 208.A O no hydrogen 2.812 N/A LYS 244.A N ASP 242.A OD1 no hydrogen 3.226 N/A LYS 244.A NZ ASP 242.A OD1 no hydrogen 2.877 N/A SER 250.A OG GLU 238.A OE2 no hydrogen 2.970 N/A SER 252.A N ASP 249.A OD2 no hydrogen 3.408 N/A SER 252.A OG ASP 249.A O no hydrogen 3.399 N/A SER 252.A OG ASP 249.A OD1 no hydrogen 2.704 N/A VAL 253.A N ASP 249.A O no hydrogen 3.090 N/A GLU 254.A N SER 250.A O no hydrogen 3.360 N/A ALA 255.A N THR 251.A O no hydrogen 2.941 N/A MET 256.A N SER 252.A O no hydrogen 2.994 N/A TYR 257.A N VAL 253.A O no hydrogen 2.878 N/A SER 258.A N GLU 254.A O no hydrogen 3.078 N/A SER 258.A OG GLN 262.A OE1 no hydrogen 3.344 N/A VAL 259.A N ALA 255.A O no hydrogen 3.425 N/A ALA 260.A N MET 256.A O no hydrogen 3.065 N/A SER 261.A N TYR 257.A O no hydrogen 2.780 N/A GLN 262.A N SER 258.A O no hydrogen 3.016 N/A CYS 263.A N VAL 259.A O no hydrogen 3.016 N/A CYS 263.A SG VAL 259.A O no hydrogen 3.226 N/A LEU 264.A N ALA 260.A O no hydrogen 2.923 N/A LYS 267.A N HIS 265.A ND1 no hydrogen 3.181 N/A LYS 268.A NZ GLU 190.A OE1 no hydrogen 3.390 N/A LYS 270.A N LYS 267.A O no hydrogen 2.982 N/A ARG 271.A NE HIS 265.A O no hydrogen 2.694 N/A ARG 271.A NH1 GLU 185.A OE1 no hydrogen 3.518 N/A ARG 271.A NH1 GLU 185.A OE2 no hydrogen 2.766 N/A ARG 271.A NH1 LYS 194.A O no hydrogen 2.774 N/A ARG 271.A NH2 GLU 185.A OE1 no hydrogen 2.838 N/A ARG 271.A NH2 HIS 265.A O no hydrogen 2.929 N/A LYS 275.A NZ GLU 139.A OE1 no hydrogen 2.818 N/A LYS 276.A N ASP 273.A O no hydrogen 3.022 N/A LYS 276.A N ASP 273.A OD1 no hydrogen 3.064 N/A LYS 276.A NZ GLN 279.A OE1 no hydrogen 3.023 N/A VAL 277.A N ASP 273.A O no hydrogen 3.025 N/A GLN 278.A N ILE 274.A O no hydrogen 2.921 N/A GLN 278.A NE2 ASN 132.A OD1 no hydrogen 3.058 N/A GLN 279.A N LYS 275.A O no hydrogen 3.198 N/A LEU 280.A N LYS 276.A O no hydrogen 2.846 N/A LEU 281.A N VAL 277.A O no hydrogen 2.941 N/A GLN 282.A N GLN 278.A O no hydrogen 3.060 N/A GLN 282.A NE2 GLN 278.A O no hydrogen 3.598 N/A GLU 283.A N GLN 279.A O no hydrogen 3.226 N/A THR 285.A N GLN 282.A O no hydrogen 3.348 N/A THR 285.A OG1 GLN 128.A OE1 no hydrogen 2.944 N/A THR 285.A OG1 GLN 282.A O no hydrogen 3.372 N/A