Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6tx2_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 3.A N HIS 1.A ND1 no hydrogen 3.251 N/A ARG 4.A N HIS 1.A O no hydrogen 3.110 N/A ARG 4.A NH1 GLU 17.A OE1 no hydrogen 3.474 N/A ARG 4.A NH2 GLU 17.A OE1 no hydrogen 3.196 N/A ARG 4.A NH2 GLU 17.A OE2 no hydrogen 2.695 N/A VAL 7.A N LEU 3.A O no hydrogen 3.066 N/A GLU 8.A N ARG 4.A O no hydrogen 3.220 N/A ASN 9.A N LYS 5.A O no hydrogen 2.945 N/A HIS 10.A N GLU 6.A O no hydrogen 3.050 N/A HIS 10.A ND1 GLU 6.A O no hydrogen 3.174 N/A TYR 11.A N VAL 7.A O no hydrogen 3.095 N/A LEU 15.A N GLU 8.A OE2 no hydrogen 3.123 N/A PHE 19.A N PRO 16.A O no hydrogen 3.072 N/A TYR 20.A OH GLU 8.A OE2 no hydrogen 2.983 N/A HIS 21.A N GLU 17.A O no hydrogen 2.985 N/A PHE 22.A N ASP 18.A O no hydrogen 2.871 N/A TRP 23.A N PHE 19.A O no hydrogen 3.230 N/A LYS 24.A N TYR 20.A O no hydrogen 3.183 N/A PHE 25.A N HIS 21.A O no hydrogen 2.866 N/A CYS 26.A N PHE 22.A O no hydrogen 2.900 N/A CYS 26.A SG PHE 22.A O no hydrogen 3.414 N/A GLU 27.A N TRP 23.A O no hydrogen 2.816 N/A GLU 28.A N LYS 24.A O no hydrogen 3.028 N/A LEU 29.A N PHE 25.A O no hydrogen 3.055 N/A ASP 30.A N CYS 26.A O no hydrogen 2.862 N/A LYS 33.A N ASP 30.A O no hydrogen 3.081 N/A LYS 33.A NZ ASP 30.A OD2 no hydrogen 2.650 N/A ASP 36.A N LYS 33.A O no hydrogen 2.923 N/A SER 37.A N PRO 34.A O no hydrogen 3.075 N/A SER 37.A OG PRO 34.A O no hydrogen 2.914 N/A SER 39.A N ASP 36.A O no hydrogen 3.021 N/A LEU 42.A N LEU 38.A O no hydrogen 2.886 N/A GLY 43.A N SER 39.A O no hydrogen 2.876 N/A LEU 44.A N LEU 38.A O no hydrogen 3.417 N/A GLN 45.A N ILE 80.A O no hydrogen 2.918 N/A LEU 46.A N SER 35.A O no hydrogen 3.009 N/A VAL 47.A N ILE 78.A O no hydrogen 2.828 N/A TYR 50.A N VAL 47.A O no hydrogen 3.295 N/A TYR 50.A OH PHE 19.A O no hydrogen 2.956 N/A ASP 51.A N GLY 48.A O no hydrogen 3.036 N/A ILE 52.A N PRO 49.A O no hydrogen 2.730 N/A LEU 53.A N PRO 49.A O no hydrogen 3.183 N/A ALA 54.A N TYR 50.A O no hydrogen 2.793 N/A GLY 55.A N ILE 52.A O no hydrogen 2.751 N/A LYS 56.A N ASP 51.A O no hydrogen 2.966 N/A LYS 56.A NZ SER 35.A OG no hydrogen 3.060 N/A HIS 57.A N HIS 57.A ND1 no hydrogen 2.840 N/A HIS 57.A NE2 GLU 6.A OE2 no hydrogen 2.557 N/A LYS 58.A N GLY 55.A O no hydrogen 3.297 N/A LYS 58.A NZ GLU 6.A OE1 no hydrogen 2.966 N/A LYS 58.A NZ GLU 6.A OE2 no hydrogen 2.906 N/A ASN 61.A N ASP 302.A OD2 no hydrogen 3.440 N/A ASN 61.A ND2 GLU 291.A OE1 no hydrogen 2.752 N/A ASN 63.A N ASN 61.A OD1 no hydrogen 2.981 N/A ASN 63.A ND2 GLU 291.A OE1 no hydrogen 2.978 N/A LEU 64.A N ASN 61.A O no hydrogen 3.159 N/A HIS 65.A N PHE 62.A O no hydrogen 3.355 N/A HIS 65.A NE2 ASP 51.A OD2 no hydrogen 2.642 N/A TRP 66.A N ASN 300.A O no hydrogen 2.794 N/A ARG 67.A N LEU 64.A O no hydrogen 3.153 N/A ARG 67.A NE ASN 63.A O no hydrogen 2.758 N/A ARG 67.A NH1 ASP 71.A O no hydrogen 3.121 N/A ARG 67.A NH1 PRO 72.A O no hydrogen 2.858 N/A ARG 67.A NH1 PHE 75.A O no hydrogen 3.100 N/A ARG 67.A NH2 PHE 75.A O no hydrogen 3.313 N/A PHE 68.A N ASP 71.A OD2 no hydrogen 2.913 N/A TYR 69.A OH GLY 261.A O no hydrogen 2.506 N/A ASP 71.A N PHE 68.A O no hydrogen 3.018 N/A GLU 74.A N GLU 74.A OE1 no hydrogen 2.792 N/A PHE 75.A N PRO 72.A O no hydrogen 2.893 N/A GLN 76.A N TYR 91.A O no hydrogen 2.837 N/A THR 77.A OG1 TRP 66.A O no hydrogen 2.765 N/A ILE 78.A N MET 89.A O no hydrogen 2.829 N/A ILE 79.A N MET 89.A O no hydrogen 3.249 N/A ILE 80.A N GLN 45.A O no hydrogen 2.911 N/A GLY 81.A N TYR 87.A O no hydrogen 2.834 N/A LYS 84.A N ASP 82.A OD1 no hydrogen 3.315 N/A LYS 84.A NZ ASP 82.A OD1 no hydrogen 2.499 N/A THR 85.A OG1 ASP 82.A O no hydrogen 3.416 N/A GLN 86.A NE2 GLN 298.A O no hydrogen 3.170 N/A TYR 87.A N ASP 82.A O no hydrogen 3.131 N/A HIS 88.A N ASN 106.A O no hydrogen 2.956 N/A HIS 88.A ND1 GLN 86.A O no hydrogen 2.859 N/A HIS 88.A NE2 ASP 71.A OD1 no hydrogen 2.711 N/A MET 89.A N ILE 79.A O no hydrogen 2.775 N/A GLY 90.A N GLY 104.A O no hydrogen 2.904 N/A TYR 91.A N GLN 76.A O no hydrogen 2.894 N/A TYR 91.A OH ASP 18.A OD2 no hydrogen 2.604 N/A PHE 92.A N TYR 102.A O no hydrogen 2.886 N/A ARG 93.A N GLU 74.A O no hydrogen 2.901 N/A ARG 93.A NH1 GLN 76.A OE1 no hydrogen 2.841 N/A ARG 93.A NH2 SER 14.A O no hydrogen 3.084 N/A ARG 93.A NH2 GLN 76.A OE1 no hydrogen 2.888 N/A ASP 97.A N SER 95.A OG no hydrogen 3.298 N/A GLU 98.A N SER 95.A O no hydrogen 3.133 N/A VAL 101.A N PHE 92.A O no hydrogen 2.786 N/A TYR 102.A OH ALA 185.A O no hydrogen 3.408 N/A VAL 103.A N GLY 118.A O no hydrogen 2.884 N/A GLY 104.A N GLY 90.A O no hydrogen 2.799 N/A ILE 105.A N VAL 115.A O no hydrogen 2.841 N/A ASN 106.A N HIS 88.A O no hydrogen 3.040 N/A ASN 106.A ND2 ASN 111.A O no hydrogen 2.875 N/A ASN 106.A ND2 ILE 113.A O no hydrogen 2.924 N/A ALA 108.A N GLN 86.A O no hydrogen 3.208 N/A LYS 109.A N THR 85.A O no hydrogen 3.076 N/A LYS 109.A NZ ASN 83.A O no hydrogen 3.310 N/A LYS 110.A N GLU 107.A O no hydrogen 2.908 N/A LYS 110.A NZ GLU 107.A OE1 no hydrogen 3.396 N/A LYS 110.A NZ GLU 107.A OE2 no hydrogen 3.203 N/A ASN 111.A N GLU 107.A O no hydrogen 3.191 N/A CYS 112.A SG PHE 182.A O no hydrogen 3.722 N/A ILE 113.A N ASN 111.A OD1 no hydrogen 2.933 N/A ILE 114.A N HIS 183.A O no hydrogen 3.038 N/A VAL 115.A N ILE 105.A O no hydrogen 2.874 N/A ASN 117.A N VAL 103.A O no hydrogen 2.785 N/A ASN 117.A ND2 ALA 124.A O no hydrogen 3.040 N/A GLY 118.A N GLN 165.A O no hydrogen 3.040 N/A ASN 120.A ND2 ASP 119.A OD1 no hydrogen 2.803 N/A ASN 120.A ND2 SER 162.A O no hydrogen 2.970 N/A VAL 121.A N ASP 18.A OD2 no hydrogen 2.881 N/A ALA 123.A N ASN 120.A OD1 no hydrogen 2.936 N/A ALA 124.A N ASN 120.A O no hydrogen 3.051 N/A VAL 125.A N VAL 121.A O no hydrogen 3.017 N/A LYS 126.A N PHE 122.A O no hydrogen 2.986 N/A LYS 126.A NZ ASP 149.A OD1 no hydrogen 2.581 N/A LEU 127.A N ALA 123.A O no hydrogen 2.773 N/A PHE 128.A N ALA 124.A O no hydrogen 3.083 N/A LEU 129.A N VAL 125.A O no hydrogen 2.722 N/A THR 130.A N LYS 126.A O no hydrogen 2.894 N/A THR 130.A OG1 LYS 126.A O no hydrogen 2.922 N/A LYS 131.A N LEU 127.A O no hydrogen 3.162 N/A LYS 132.A N PHE 128.A O no hydrogen 2.812 N/A LEU 133.A N LEU 129.A O no hydrogen 2.783 N/A LYS 134.A N LYS 131.A O no hydrogen 3.215 N/A GLU 135.A N LYS 132.A O no hydrogen 2.953 N/A ILE 136.A N LEU 133.A O no hydrogen 3.234 N/A LYS 141.A N ASP 138.A OD2 no hydrogen 2.605 N/A ILE 142.A N ASP 138.A O no hydrogen 2.880 N/A ASN 143.A N LYS 139.A O no hydrogen 2.843 N/A LEU 144.A N LYS 140.A O no hydrogen 2.887 N/A LEU 145.A N LYS 141.A O no hydrogen 2.873 N/A LYS 146.A N ILE 142.A O no hydrogen 2.972 N/A ASN 147.A N ASN 143.A O no hydrogen 3.065 N/A ILE 148.A N LEU 144.A O no hydrogen 3.009 N/A ASP 149.A N LEU 145.A O no hydrogen 2.715 N/A GLU 150.A N LYS 146.A O no hydrogen 2.911 N/A LYS 151.A N ASN 147.A O no hydrogen 2.964 N/A LEU 152.A N ILE 148.A O no hydrogen 2.822 N/A THR 153.A N ASP 149.A O no hydrogen 2.910 N/A THR 153.A OG1 ASP 149.A O no hydrogen 2.719 N/A THR 153.A OG1 ASP 149.A OD1 no hydrogen 3.297 N/A GLU 154.A N GLU 150.A O no hydrogen 3.000 N/A ALA 155.A N LYS 151.A O no hydrogen 2.957 N/A ALA 156.A N LEU 152.A O no hydrogen 2.842 N/A ARG 157.A N THR 153.A O no hydrogen 2.825 N/A GLU 158.A N GLU 154.A O no hydrogen 2.856 N/A LEU 159.A N ALA 155.A O no hydrogen 3.072 N/A GLY 160.A N ARG 157.A O no hydrogen 3.123 N/A TYR 161.A N ALA 156.A O no hydrogen 2.941 N/A TYR 161.A OH HIS 21.A ND1 no hydrogen 3.348 N/A GLU 164.A N SER 162.A OG no hydrogen 2.969 N/A GLN 165.A NE2 PRO 116.A O no hydrogen 2.875 N/A THR 167.A OG1 ASP 119.A OD2 no hydrogen 3.304 N/A LYS 169.A NZ VAL 101.A O no hydrogen 2.674 N/A MET 170.A N THR 167.A OG1 no hydrogen 3.288 N/A LYS 171.A N THR 167.A O no hydrogen 2.928 N/A GLN 172.A N VAL 168.A O no hydrogen 2.690 N/A ARG 173.A N LYS 169.A O no hydrogen 2.843 N/A ARG 173.A NE ASP 94.A OD2 no hydrogen 2.896 N/A ARG 173.A NH1 ALA 185.A O no hydrogen 2.708 N/A ARG 173.A NH2 ASP 94.A OD1 no hydrogen 2.713 N/A ARG 173.A NH2 ALA 185.A O no hydrogen 3.157 N/A ARG 173.A NH2 GLY 186.A O no hydrogen 3.078 N/A ASP 174.A N MET 170.A O no hydrogen 3.060 N/A LYS 175.A N GLN 172.A O no hydrogen 3.085 N/A LYS 176.A N ARG 173.A O no hydrogen 2.747 N/A VAL 177.A N ASP 174.A O no hydrogen 3.165 N/A VAL 178.A N LEU 187.A O no hydrogen 2.881 N/A THR 179.A OG1 GLU 252.A OE2 no hydrogen 2.862 N/A THR 181.A OG1 LYS 180.A O no hydrogen 2.668 N/A PHE 182.A N ASP 256.A OD1 no hydrogen 2.944 N/A HIS 183.A N THR 181.A OG1 no hydrogen 3.174 N/A GLY 184.A N THR 181.A O no hydrogen 3.152 N/A ALA 185.A N HIS 183.A ND1 no hydrogen 2.999 N/A GLY 186.A N LYS 180.A O no hydrogen 3.079 N/A LEU 187.A N THR 179.A O no hydrogen 2.921 N/A ASP 192.A N VAL 196.A O no hydrogen 3.002 N/A ASN 194.A N ASP 192.A OD1 no hydrogen 2.864 N/A ASP 195.A N ASP 192.A O no hydrogen 3.029 N/A VAL 196.A N ASP 192.A OD1 no hydrogen 2.928 N/A GLY 197.A N ASP 246.A OD1 no hydrogen 2.692 N/A TYR 198.A OH GLU 252.A OE1 no hydrogen 2.534 N/A ARG 199.A NE ASP 246.A OD2 no hydrogen 2.859 N/A ARG 199.A NH2 GLU 244.A OE1 no hydrogen 2.791 N/A ARG 199.A NH2 ASP 246.A OD2 no hydrogen 3.144 N/A ASP 207.A N THR 204.A OG1 no hydrogen 3.212 N/A LEU 208.A N THR 204.A O no hydrogen 2.740 N/A LYS 209.A N ASP 205.A O no hydrogen 2.879 N/A ARG 210.A N ALA 206.A O no hydrogen 3.089 N/A ILE 211.A N ASP 207.A O no hydrogen 2.931 N/A CYS 212.A N LEU 208.A O no hydrogen 2.866 N/A CYS 212.A SG LEU 208.A O no hydrogen 3.444 N/A LYS 213.A N LYS 209.A O no hydrogen 2.860 N/A LYS 213.A NZ GLU 217.A OE2 no hydrogen 3.026 N/A THR 214.A N ARG 210.A O no hydrogen 3.107 N/A THR 214.A OG1 ILE 211.A O no hydrogen 2.744 N/A ILE 215.A N ILE 211.A O no hydrogen 3.287 N/A VAL 216.A N CYS 212.A O no hydrogen 3.068 N/A GLU 217.A N LYS 213.A O no hydrogen 3.030 N/A ALA 218.A N ILE 215.A O no hydrogen 3.217 N/A SER 220.A OG GLU 223.A OE1 no hydrogen 3.086 N/A GLU 223.A N SER 220.A OG no hydrogen 3.134 N/A ARG 224.A N SER 220.A O no hydrogen 2.948 N/A ARG 224.A NH1 ASP 221.A OD1 no hydrogen 2.904 N/A LEU 225.A N ASP 221.A O no hydrogen 2.925 N/A LYS 226.A N GLU 222.A O no hydrogen 3.145 N/A LYS 226.A NZ GLU 222.A OE2 no hydrogen 3.058 N/A ALA 227.A N GLU 223.A O no hydrogen 2.815 N/A PHE 228.A N ARG 224.A O no hydrogen 2.917 N/A PHE 228.A N LEU 225.A O no hydrogen 3.266 N/A ALA 229.A N LYS 226.A O no hydrogen 3.003 N/A GLN 232.A N PHE 228.A O no hydrogen 2.977 N/A GLU 233.A N ALA 229.A O no hydrogen 3.014 N/A MET 234.A N PRO 230.A O no hydrogen 3.065 N/A MET 235.A N ILE 231.A O no hydrogen 2.959 N/A THR 236.A N GLN 232.A O no hydrogen 3.210 N/A THR 236.A OG1 GLN 232.A O no hydrogen 3.383 N/A PHE 237.A N GLU 233.A O no hydrogen 3.007 N/A VAL 238.A N MET 234.A O no hydrogen 2.883 N/A GLN 239.A N MET 235.A O no hydrogen 3.098 N/A PHE 240.A N THR 236.A O no hydrogen 3.213 N/A ALA 241.A N PHE 237.A O no hydrogen 2.933 N/A ASN 242.A N VAL 238.A O no hydrogen 2.706 N/A ASP 243.A N GLN 239.A O no hydrogen 2.965 N/A GLU 244.A N PHE 240.A O no hydrogen 3.138 N/A GLU 244.A N ALA 241.A O no hydrogen 3.075 N/A CYS 245.A N ASN 242.A O no hydrogen 3.035 N/A CYS 245.A SG TYR 247.A OH no hydrogen 3.805 N/A ASP 246.A N ALA 241.A O no hydrogen 2.810 N/A GLY 248.A N GLY 197.A O no hydrogen 2.959 N/A MET 249.A N ASP 246.A O no hydrogen 3.312 N/A LEU 251.A N TYR 247.A O no hydrogen 3.473 N/A GLU 252.A N GLY 248.A O no hydrogen 2.964 N/A LEU 253.A N MET 249.A O no hydrogen 3.006 N/A GLY 254.A N GLY 250.A O no hydrogen 2.983 N/A MET 255.A N LEU 251.A O no hydrogen 2.913 N/A ASP 256.A N GLU 252.A O no hydrogen 2.929 N/A LEU 257.A N LEU 253.A O no hydrogen 3.003 N/A PHE 258.A N GLY 254.A O no hydrogen 2.883 N/A CYS 259.A N MET 255.A O no hydrogen 2.814 N/A CYS 259.A SG MET 255.A O no hydrogen 3.159 N/A TYR 260.A N ASP 256.A O no hydrogen 2.922 N/A TYR 264.A N SER 262.A OG no hydrogen 3.057 N/A PHE 265.A N SER 262.A O no hydrogen 3.053 N/A HIS 266.A N HIS 263.A O no hydrogen 3.317 N/A ALA 269.A N PHE 265.A O no hydrogen 2.877 N/A GLY 270.A N HIS 266.A O no hydrogen 2.793 N/A GLN 271.A N LYS 267.A O no hydrogen 3.049 N/A GLN 271.A N VAL 268.A O no hydrogen 2.868 N/A LEU 272.A N VAL 268.A O no hydrogen 2.874 N/A LEU 272.A N ALA 269.A O no hydrogen 3.214 N/A LEU 273.A N ALA 269.A O no hydrogen 2.901 N/A ALA 276.A N LEU 272.A O no hydrogen 3.017 N/A TYR 277.A N LEU 273.A O no hydrogen 2.936 N/A TYR 277.A OH GLU 74.A OE1 no hydrogen 3.108 N/A TYR 277.A OH GLU 74.A OE2 no hydrogen 2.550 N/A ASN 278.A N PRO 274.A O no hydrogen 2.920 N/A LEU 279.A N LEU 275.A O no hydrogen 2.801 N/A LEU 280.A N ALA 276.A O no hydrogen 2.922 N/A LYS 281.A N ASN 278.A O no hydrogen 2.785 N/A ARG 282.A N TYR 277.A O no hydrogen 2.698 N/A ARG 282.A NH1 VAL 188.A O no hydrogen 2.989 N/A ARG 282.A NH2 VAL 188.A O no hydrogen 2.777 N/A ASN 283.A ND2 ASN 278.A OD1 no hydrogen 3.429 N/A PHE 285.A N ARG 282.A O no hydrogen 2.867 N/A ALA 286.A N ARG 282.A O no hydrogen 3.429 N/A GLU 287.A N ASN 283.A O no hydrogen 3.124 N/A ILE 288.A N LEU 284.A O no hydrogen 2.926 N/A ILE 289.A N PHE 285.A O no hydrogen 2.962 N/A GLU 290.A N ALA 286.A O no hydrogen 3.165 N/A GLU 291.A N GLU 287.A O no hydrogen 3.120 N/A HIS 292.A N ILE 288.A O no hydrogen 2.813 N/A LEU 293.A N ILE 289.A O no hydrogen 2.836 N/A ALA 294.A N GLU 290.A O no hydrogen 3.057 N/A ASN 295.A N HIS 292.A O no hydrogen 2.979 N/A ARG 296.A NE TYR 69.A O no hydrogen 2.950 N/A ARG 296.A NH1 TYR 69.A O no hydrogen 3.102 N/A ARG 296.A NH1 PHE 258.A O no hydrogen 2.726 N/A ARG 296.A NH2 PHE 258.A O no hydrogen 3.315 N/A ARG 296.A NH2 HIS 266.A NE2 no hydrogen 3.050 N/A SER 297.A N ASN 295.A O no hydrogen 3.039 N/A SER 297.A OG GLU 299.A O no hydrogen 2.860 N/A GLU 299.A N SER 297.A OG no hydrogen 2.925 N/A ASP 302.A N HIS 65.A ND1 no hydrogen 2.998 N/A LEU 304.A N ILE 301.A O no hydrogen 3.151 N/A