Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6x4i_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 5.A N GLU 5.A OE1 no hydrogen 2.630 N/A ASN 6.A N SER 3.A OG.A no hydrogen 3.243 N/A ASN 6.A N SER 3.A OG.B no hydrogen 2.519 N/A ASN 6.A ND2 GLN 20.A O no hydrogen 2.780 N/A ASN 6.A ND2 GLY 22.A O no hydrogen 2.880 N/A VAL 7.A N SER 3.A O.A no hydrogen 2.928 N/A VAL 7.A N SER 3.A O.B no hydrogen 3.048 N/A ALA 8.A N LEU 4.A O no hydrogen 3.051 N/A PHE 9.A N GLU 5.A O no hydrogen 3.012 N/A ASN 10.A N ASN 6.A O no hydrogen 3.059 N/A ASN 10.A ND2 ASN 6.A O no hydrogen 2.880 N/A ASN 10.A ND2 GLN 20.A O no hydrogen 2.956 N/A VAL 11.A N VAL 7.A O no hydrogen 2.996 N/A VAL 12.A N ALA 8.A O no hydrogen 2.932 N/A ASN 13.A N PHE 9.A O no hydrogen 2.939 N/A ASN 13.A ND2 PHE 9.A O no hydrogen 2.884 N/A LYS 14.A N ASN 10.A O no hydrogen 2.674 N/A GLY 15.A N VAL 11.A O no hydrogen 2.985 N/A PHE 17.A N ALA 61.A O no hydrogen 2.827 N/A ASP 18.A N ASN 10.A OD1 no hydrogen 2.951 N/A GLN 20.A N ASN 10.A OD1 no hydrogen 2.906 N/A GLN 20.A NE2 ASP 18.A O no hydrogen 3.504 N/A GLN 20.A NE2 ASP 18.A OD2 no hydrogen 3.020 N/A VAL 24.A N GLU 5.A O no hydrogen 3.397 N/A SER 27.A N TYR 34.A O no hydrogen 2.899 N/A ILE 29.A N.A THR 32.A O.A no hydrogen 3.069 N/A ILE 29.A N.A THR 32.A O.B no hydrogen 3.194 N/A ILE 29.A N.B THR 32.A O.A no hydrogen 3.052 N/A ILE 29.A N.B THR 32.A O.B no hydrogen 3.187 N/A THR 32.A N.A ILE 29.A O.A no hydrogen 2.980 N/A THR 32.A N.A ILE 29.A O.B no hydrogen 2.786 N/A THR 32.A N.B ILE 29.A O.A no hydrogen 2.994 N/A THR 32.A N.B ILE 29.A O.B no hydrogen 2.863 N/A THR 32.A OG1.A ASN 30.A O.B no hydrogen 3.036 N/A THR 32.A OG1.B ILE 29.A O.A no hydrogen 3.025 N/A THR 32.A OG1.B ILE 29.A O.B no hydrogen 2.438 N/A THR 32.A OG1.B TYR 34.A OH no hydrogen 3.365 N/A VAL 33.A N PHE 45.A O no hydrogen 2.818 N/A TYR 34.A N SER 27.A O no hydrogen 2.727 N/A THR 35.A N VAL 42.A O no hydrogen 2.890 N/A THR 35.A OG1 PRO 25.A O no hydrogen 2.686 N/A LYS 36.A N PRO 25.A O no hydrogen 3.303 N/A VAL 37.A N VAL 40.A O no hydrogen 2.756 N/A VAL 40.A N VAL 37.A O no hydrogen 3.350 N/A VAL 42.A N THR 35.A O no hydrogen 2.780 N/A LEU 44.A N VAL 33.A O no hydrogen 2.745 N/A PHE 45.A N VAL 33.A O no hydrogen 3.355 N/A ASN 47.A N ASN 31.A O.A no hydrogen 2.727 N/A ASN 47.A N ASN 31.A O.B no hydrogen 2.977 N/A ASN 47.A ND2 ASN 31.A OD1.A no hydrogen 2.970 N/A ASN 47.A ND2 ASN 31.A OD1.B no hydrogen 2.996 N/A ASN 47.A ND2 LEU 51.A O no hydrogen 2.853 N/A THR 49.A N ASN 47.A OD1 no hydrogen 2.871 N/A THR 49.A OG1 ASN 47.A OD1 no hydrogen 2.712 N/A LEU 51.A N THR 49.A OG1 no hydrogen 2.942 N/A ALA 56.A N PRO 52.A O no hydrogen 2.906 N/A PHE 57.A N VAL 53.A O no hydrogen 2.942 N/A GLU 58.A N ASN 54.A O no hydrogen 3.279 N/A LEU 59.A N VAL 55.A O no hydrogen 3.036 N/A TRP 60.A N ALA 56.A O no hydrogen 2.884 N/A ALA 61.A N PHE 57.A O no hydrogen 2.926 N/A LYS 62.A N GLU 58.A O no hydrogen 2.984 N/A LYS 62.A N LEU 59.A O no hydrogen 3.225 N/A LYS 62.A NZ GLU 58.A OE2 no hydrogen 2.899 N/A LYS 62.A NZ VAL 103.A O no hydrogen 2.657 N/A ARG 63.A N TRP 60.A O no hydrogen 3.113 N/A ARG 63.A NH1 TRP 60.A O no hydrogen 2.872 N/A ASN 64.A N VAL 86.A O no hydrogen 2.787 N/A ASN 64.A ND2 THR 85.A OG1 no hydrogen 3.263 N/A LYS 66.A N ASN 64.A OD1 no hydrogen 2.827 N/A LYS 66.A NZ ASP 126.A OD2 no hydrogen 2.921 N/A VAL 68.A N SER 163.A O no hydrogen 2.852 N/A LYS 72.A N ASP 274.A OD2 no hydrogen 2.893 N/A LYS 72.A NZ THR 197.A OG1 no hydrogen 2.816 N/A LYS 72.A NZ SER 199.A OG no hydrogen 2.755 N/A ILE 73.A N GLU 70.A O no hydrogen 2.929 N/A LEU 74.A N GLU 70.A O no hydrogen 3.300 N/A ASN 75.A N VAL 71.A O no hydrogen 2.799 N/A ASN 76.A N LYS 72.A O no hydrogen 2.966 N/A ASN 76.A ND2 THR 276.A OG1 no hydrogen 2.954 N/A ASN 76.A ND2 ASP 325.A O no hydrogen 2.952 N/A LEU 77.A N ILE 73.A O no hydrogen 2.986 N/A GLY 78.A N ASN 75.A O no hydrogen 3.013 N/A VAL 79.A N LEU 74.A O no hydrogen 2.961 N/A ASP 80.A N THR 122.A O no hydrogen 2.888 N/A ALA 83.A N PHE 124.A O no hydrogen 3.014 N/A ASN 84.A ND2 LYS 111.A O no hydrogen 3.413 N/A ASP 89.A N ALA 94.A O no hydrogen 2.752 N/A LYS 91.A N ASP 89.A OD1 no hydrogen 2.976 N/A ARG 92.A N ASP 89.A O no hydrogen 3.252 N/A ARG 92.A N ASP 89.A OD1 no hydrogen 3.191 N/A ARG 92.A NH2 ASP 89.A OD2 no hydrogen 3.419 N/A ARG 92.A NH2 PRO 95.A O no hydrogen 2.972 N/A ALA 94.A N ASP 89.A O no hydrogen 3.165 N/A ALA 96.A N ILE 87.A O no hydrogen 2.832 N/A THR 100.A N THR 107.A O no hydrogen 3.206 N/A THR 100.A OG1 THR 107.A OG1 no hydrogen 2.661 N/A THR 100.A OG1 ASP 108.A OD1 no hydrogen 2.637 N/A GLY 102.A N ALA 110.A O no hydrogen 2.805 N/A VAL 103.A N ASP 108.A OD1 no hydrogen 2.853 N/A CYS 104.A N ASP 108.A OD1 no hydrogen 3.018 N/A THR 107.A N CYS 104.A O no hydrogen 3.140 N/A THR 107.A OG1 THR 100.A OG1 no hydrogen 2.661 N/A ASP 108.A N CYS 104.A O no hydrogen 2.706 N/A ILE 109.A N THR 100.A O no hydrogen 3.024 N/A LYS 111.A N GLU 115.A OE1 no hydrogen 2.694 N/A LYS 112.A N GLU 115.A OE1 no hydrogen 3.005 N/A GLU 115.A N LYS 112.A O no hydrogen 3.214 N/A CYS 118.A N GLU 115.A O no hydrogen 3.071 N/A CYS 118.A SG LYS 112.A O no hydrogen 3.971 N/A ALA 119.A N THR 116.A O no hydrogen 3.037 N/A LEU 121.A N CYS 118.A O no hydrogen 3.074 N/A THR 122.A N ASP 80.A OD2 no hydrogen 2.981 N/A VAL 123.A N ASN 141.A O no hydrogen 3.293 N/A PHE 124.A N ILE 81.A O no hydrogen 2.806 N/A PHE 125.A N VAL 143.A O no hydrogen 2.702 N/A ASP 126.A N GLN 132.A OE1 no hydrogen 2.720 N/A GLY 127.A N ILE 145.A O no hydrogen 2.741 N/A ARG 128.A N ASP 126.A OD1 no hydrogen 3.063 N/A ARG 128.A NE ASP 126.A OD1 no hydrogen 2.882 N/A ARG 128.A NE ASP 126.A OD2 no hydrogen 3.299 N/A ARG 128.A NH1 PRO 67.A O no hydrogen 2.754 N/A ARG 128.A NH2 PRO 67.A O no hydrogen 2.698 N/A ARG 128.A NH2 ASP 126.A OD2 no hydrogen 2.851 N/A VAL 129.A N ASP 126.A O no hydrogen 2.922 N/A GLN 132.A N VAL 129.A O no hydrogen 3.212 N/A GLN 132.A NE2 ALA 83.A O no hydrogen 3.300 N/A LEU 135.A N GLY 131.A O no hydrogen 3.061 N/A PHE 136.A N GLN 132.A O no hydrogen 2.924 N/A ARG 137.A N VAL 133.A O no hydrogen 2.970 N/A ARG 137.A NH1 LYS 151.A O no hydrogen 3.410 N/A ARG 137.A NH2 LYS 151.A O no hydrogen 2.698 N/A ASN 138.A N ASP 134.A O no hydrogen 3.144 N/A ALA 139.A N PHE 136.A O no hydrogen 3.115 N/A ASN 141.A ND2 ALA 119.A O no hydrogen 2.863 N/A GLY 142.A N LYS 183.A O no hydrogen 3.172 N/A VAL 143.A N VAL 123.A O no hydrogen 2.848 N/A LEU 144.A N TYR 181.A O no hydrogen 2.851 N/A ILE 145.A N PHE 125.A O no hydrogen 3.134 N/A THR 146.A N ASN 179.A O no hydrogen 3.064 N/A THR 146.A OG1 GLY 148.A O no hydrogen 2.731 N/A LEU 153.A N VAL 150.A O no hydrogen 3.177 N/A SER 156.A N TYR 180.A O no hydrogen 3.110 N/A SER 156.A OG TYR 326.A OH no hydrogen 2.858 N/A GLY 158.A N PHE 178.A O no hydrogen 2.922 N/A GLN 161.A N GLN 161.A OE1 no hydrogen 2.712 N/A GLN 161.A NE2 THR 197.A O no hydrogen 2.766 N/A GLN 161.A NE2 SER 199.A OG no hydrogen 3.149 N/A ALA 162.A N LEU 169.A O no hydrogen 3.025 N/A SER 163.A N VAL 68.A O no hydrogen 2.815 N/A LEU 164.A N VAL 167.A O no hydrogen 2.826 N/A VAL 167.A N LEU 164.A O no hydrogen 2.919 N/A THR 168.A OG1 GLU 70.A OE2 no hydrogen 2.829 N/A LEU 169.A N ALA 162.A O no hydrogen 2.939 N/A GLY 171.A N THR 176.A OG1 no hydrogen 2.825 N/A LYS 175.A NZ GLU 147.A O no hydrogen 3.112 N/A LYS 175.A NZ GLN 177.A O no hydrogen 2.893 N/A THR 176.A OG1 LYS 160.A O no hydrogen 2.702 N/A GLN 177.A NE2 GLY 158.A O no hydrogen 3.071 N/A ASN 179.A N THR 146.A O no hydrogen 2.855 N/A ASN 179.A ND2 GLY 148.A O no hydrogen 3.099 N/A TYR 180.A N SER 156.A O no hydrogen 2.769 N/A TYR 181.A N LEU 144.A O no hydrogen 2.933 N/A LYS 182.A NZ LEU 77.A O no hydrogen 2.895 N/A LYS 183.A N GLY 142.A O no hydrogen 2.928 N/A LYS 183.A NZ PHE 136.A O no hydrogen 3.186 N/A LYS 183.A NZ ALA 139.A O no hydrogen 2.702 N/A VAL 184.A N VAL 187.A O no hydrogen 2.951 N/A ASP 185.A N ASN 141.A OD1 no hydrogen 2.856 N/A GLY 186.A N ARG 140.A O no hydrogen 2.761 N/A VAL 187.A N VAL 184.A O no hydrogen 2.989 N/A GLN 189.A N LYS 182.A O no hydrogen 2.757 N/A GLN 189.A NE2 VAL 187.A O no hydrogen 2.869 N/A THR 194.A OG1 TYR 195.A O no hydrogen 2.718 N/A TYR 195.A N THR 323.A O no hydrogen 2.933 N/A TYR 195.A OH GLU 306.A OE1 no hydrogen 2.564 N/A THR 197.A N ASP 325.A OD1 no hydrogen 2.948 N/A THR 197.A OG1 ASP 325.A OD1 no hydrogen 3.338 N/A THR 197.A OG1 ASP 325.A OD2 no hydrogen 2.671 N/A GLN 198.A N ASP 298.A O no hydrogen 2.763 N/A GLN 198.A NE2 PHE 196.A O no hydrogen 3.555 N/A SER 199.A OG GLU 70.A OE1 no hydrogen 2.416 N/A SER 199.A OG GLU 70.A OE2 no hydrogen 3.354 N/A ARG 200.A N ASP 298.A OD2 no hydrogen 2.863 N/A ARG 200.A NE ASP 298.A OD1 no hydrogen 3.408 N/A ARG 200.A NE ASP 298.A OD2 no hydrogen 3.160 N/A ARG 200.A NH1 LYS 206.A O no hydrogen 3.072 N/A ARG 200.A NH1 GLU 212.A OE1 no hydrogen 2.685 N/A ARG 200.A NH1 GLU 212.A OE2 no hydrogen 3.543 N/A ARG 200.A NH2 GLU 212.A OE2 no hydrogen 3.000 N/A ARG 200.A NH2 ASP 298.A OD1 no hydrogen 2.944 N/A ASN 201.A ND2 GLU 204.A OE2 no hydrogen 3.463 N/A GLU 204.A N ASN 201.A OD1 no hydrogen 3.153 N/A ARG 208.A N GLU 212.A OE1 no hydrogen 2.836 N/A ARG 208.A NH1 GLN 198.A O no hydrogen 3.035 N/A ARG 208.A NH1 GLN 198.A OE1 no hydrogen 2.763 N/A SER 209.A OG ASP 302.A OD1 no hydrogen 2.532 N/A GLN 210.A NE2 ASP 214.A OD1 no hydrogen 2.932 N/A GLU 212.A N SER 209.A OG no hydrogen 3.242 N/A ILE 213.A N SER 209.A O no hydrogen 3.050 N/A ASP 214.A N GLN 210.A O no hydrogen 2.890 N/A PHE 215.A N MET 211.A O no hydrogen 2.827 N/A LEU 216.A N GLU 212.A O no hydrogen 3.079 N/A GLU 217.A N ILE 213.A O no hydrogen 2.973 N/A LEU 218.A N ASP 214.A O no hydrogen 2.786 N/A ALA 219.A N GLU 222.A OE2 no hydrogen 3.201 N/A PHE 223.A N ALA 219.A O no hydrogen 3.002 N/A ILE 224.A N MET 220.A O no hydrogen 3.097 N/A GLU 225.A N ASP 221.A O no hydrogen 3.179 N/A ARG 226.A N GLU 222.A O no hydrogen 2.969 N/A ARG 226.A NH1 ASP 214.A OD2 no hydrogen 3.291 N/A TYR 227.A N PHE 223.A O no hydrogen 3.140 N/A TYR 227.A OH ASP 214.A OD2 no hydrogen 2.466 N/A LYS 228.A N GLU 225.A O no hydrogen 3.231 N/A LEU 229.A N ILE 224.A O no hydrogen 2.902 N/A GLU 230.A N GLU 230.A OE1 no hydrogen 2.706 N/A TYR 232.A N LEU 229.A O no hydrogen 3.261 N/A GLU 235.A N.A GLU 235.A OE1.A no hydrogen 2.610 N/A HIS 236.A N ALA 233.A O no hydrogen 3.054 N/A ILE 237.A N ALA 233.A O no hydrogen 2.790 N/A VAL 238.A N PHE 234.A O no hydrogen 3.060 N/A TYR 239.A N PHE 234.A O no hydrogen 3.094 N/A ASP 241.A N GLY 248.A O no hydrogen 2.847 N/A SER 243.A N ASP 241.A OD1 no hydrogen 3.041 N/A SER 243.A OG ASP 241.A OD1 no hydrogen 2.698 N/A LEU 247.A N SER 290.A O no hydrogen 2.769 N/A GLY 248.A N ASP 241.A O no hydrogen 2.885 N/A LEU 250.A N HIS 236.A O no hydrogen 3.214 N/A HIS 251.A N ILE 237.A O no hydrogen 2.895 N/A HIS 251.A ND1 SER 295.A O no hydrogen 2.799 N/A LEU 253.A N ILE 297.A O no hydrogen 3.096 N/A GLY 255.A N LEU 252.A O.A no hydrogen 2.910 N/A GLY 255.A N LEU 252.A O.B no hydrogen 2.986 N/A LEU 256.A N LEU 252.A O.A no hydrogen 3.310 N/A LEU 256.A N LEU 252.A O.B no hydrogen 3.291 N/A ALA 257.A N LEU 253.A O no hydrogen 2.768 N/A LYS 258.A N ILE 254.A O no hydrogen 2.958 N/A LYS 258.A NZ PHE 215.A O no hydrogen 3.108 N/A LYS 258.A NZ LEU 218.A O no hydrogen 3.340 N/A ARG 259.A N GLY 255.A O no hydrogen 3.102 N/A ARG 259.A NE ASP 284.A OD1 no hydrogen 3.233 N/A ARG 259.A NH2 ASP 284.A OD1 no hydrogen 3.157 N/A ARG 259.A NH2 ASP 284.A OD2 no hydrogen 2.765 N/A PHE 260.A N LEU 256.A O no hydrogen 2.844 N/A LYS 261.A N ALA 257.A O no hydrogen 3.240 N/A GLU 262.A N ARG 259.A O no hydrogen 3.041 N/A SER 263.A N ARG 259.A O no hydrogen 2.689 N/A GLU 266.A N THR 283.A O no hydrogen 2.867 N/A GLU 268.A N PHE 281.A O no hydrogen 2.881 N/A SER 275.A OG VAL 277.A O no hydrogen 2.583 N/A THR 276.A OG1 ASP 325.A OD2 no hydrogen 2.790 N/A LYS 278.A N VAL 296.A O no hydrogen 3.009 N/A LYS 278.A NZ ASP 269.A OD1 no hydrogen 3.016 N/A LYS 278.A NZ ILE 271.A O no hydrogen 2.925 N/A LYS 278.A NZ MET 273.A O no hydrogen 2.809 N/A TYR 280.A N CYS 294.A O no hydrogen 2.995 N/A PHE 281.A N GLU 268.A O no hydrogen 3.039 N/A ILE 282.A N LYS 291.A O no hydrogen 3.014 N/A THR 283.A N GLU 266.A O no hydrogen 2.991 N/A ASP 284.A N SER 289.A O no hydrogen 2.831 N/A THR 287.A N ASP 284.A OD2 no hydrogen 3.038 N/A THR 287.A OG1 ASP 284.A OD2 no hydrogen 2.684 N/A GLY 288.A N ASP 284.A O no hydrogen 2.884 N/A SER 289.A N THR 287.A OG1 no hydrogen 3.121 N/A SER 289.A OG HIS 244.A O no hydrogen 2.668 N/A SER 290.A N SER 245.A O no hydrogen 3.022 N/A LYS 291.A N ILE 282.A O no hydrogen 2.992 N/A LYS 291.A NZ LEU 247.A O no hydrogen 2.915 N/A LYS 291.A NZ GLY 249.A O no hydrogen 2.963 N/A CYS 294.A N TYR 280.A O no hydrogen 2.800 N/A CYS 294.A SG GLY 249.A O no hydrogen 3.641 N/A CYS 294.A SG LEU 250.A O no hydrogen 3.207 N/A SER 295.A OG HIS 251.A ND1 no hydrogen 3.389 N/A SER 295.A OG PRO 345.A O no hydrogen 2.778 N/A VAL 296.A N LYS 278.A O no hydrogen 2.745 N/A ILE 297.A N HIS 251.A O no hydrogen 3.014 N/A LEU 301.A N GLU 212.A OE2 no hydrogen 2.957 N/A PHE 304.A N LEU 300.A O no hydrogen 2.975 N/A VAL 305.A N LEU 301.A O no hydrogen 2.912 N/A GLU 306.A N ASP 302.A O no hydrogen 3.017 N/A ILE 307.A N ASP 303.A O no hydrogen 2.950 N/A ILE 308.A N PHE 304.A O no hydrogen 3.018 N/A LYS 309.A N VAL 305.A O no hydrogen 2.938 N/A LYS 309.A NZ TYR 227.A O no hydrogen 3.308 N/A SER 310.A N ILE 307.A O no hydrogen 3.038 N/A SER 310.A OG GLU 306.A O no hydrogen 2.530 N/A GLN 311.A NE2 ILE 307.A O no hydrogen 2.941 N/A SER 314.A N ASP 312.A OD1 no hydrogen 2.945 N/A SER 314.A OG ASP 312.A OD1 no hydrogen 2.543 N/A LYS 318.A N LEU 333.A O no hydrogen 3.144 N/A VAL 320.A N PHE 331.A O no hydrogen 2.718 N/A VAL 322.A N ILE 329.A O no hydrogen 2.921 N/A THR 323.A OG1 GLU 328.A OE1 no hydrogen 2.460 N/A THR 323.A OG1 GLU 328.A OE2 no hydrogen 3.470 N/A ILE 324.A N THR 327.A O no hydrogen 2.822 N/A ASP 325.A N TYR 195.A O no hydrogen 2.782 N/A TYR 326.A N THR 194.A OG1 no hydrogen 3.039 N/A TYR 326.A OH SER 156.A OG no hydrogen 2.858 N/A THR 327.A N ILE 324.A O no hydrogen 3.006 N/A ILE 329.A N VAL 322.A O no hydrogen 2.823 N/A PHE 331.A N VAL 320.A O no hydrogen 2.653 N/A MET 332.A N TYR 344.A O no hydrogen 2.898 N/A LEU 333.A N LYS 318.A O no hydrogen 2.964 N/A TRP 334.A N THR 342.A O no hydrogen 2.947 N/A CYS 335.A N VAL 316.A O no hydrogen 2.794 N/A LYS 336.A N HIS 339.A O no hydrogen 2.909 N/A HIS 339.A N LYS 336.A O no hydrogen 3.122 N/A HIS 339.A ND1 VAL 340.A O no hydrogen 3.212 N/A VAL 340.A N GLY 231.A O no hydrogen 2.937 N/A GLU 341.A N TRP 334.A O no hydrogen 2.652 N/A THR 342.A N TRP 334.A O no hydrogen 3.260 N/A TYR 344.A N MET 332.A O no hydrogen 3.114 N/A LYS 346.A N SER 330.A O no hydrogen 2.861 N/A