Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 6xed_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 4.A N MET 1.A O no hydrogen 2.983 N/A LYS 5.A N MET 1.A O no hydrogen 3.197 N/A GLU 6.A N GLU 2.A O no hydrogen 2.822 N/A PHE 7.A N MET 3.A O no hydrogen 2.750 N/A GLU 8.A N GLU 4.A O no hydrogen 3.105 N/A GLN 9.A N LYS 5.A O no hydrogen 3.052 N/A ILE 10.A N GLU 6.A O no hydrogen 2.908 N/A ASP 11.A N PHE 7.A O no hydrogen 2.918 N/A LYS 12.A N GLU 8.A O no hydrogen 2.821 N/A SER 13.A N GLN 9.A O no hydrogen 3.008 N/A SER 13.A OG GLN 9.A O no hydrogen 3.127 N/A SER 13.A OG ILE 10.A O no hydrogen 3.232 N/A SER 13.A OG SER 15.A OG no hydrogen 2.732 N/A GLY 14.A N ASP 11.A O no hydrogen 3.160 N/A SER 15.A N ILE 10.A O no hydrogen 3.143 N/A SER 15.A OG SER 13.A OG no hydrogen 2.732 N/A TRP 16.A NE1 ASP 11.A OD1 no hydrogen 2.695 N/A ILE 19.A N SER 15.A O no hydrogen 2.958 N/A TYR 20.A N TRP 16.A O no hydrogen 2.896 N/A TYR 20.A OH ILE 260.A O no hydrogen 2.631 N/A GLN 21.A N ALA 17.A O no hydrogen 2.851 N/A ASP 22.A N ALA 18.A O no hydrogen 2.994 N/A ILE 23.A N ILE 19.A O no hydrogen 3.230 N/A ARG 24.A N TYR 20.A O no hydrogen 3.076 N/A ARG 24.A NE GLN 21.A OE1 no hydrogen 3.120 N/A ARG 24.A NH1 GLN 21.A OE1 no hydrogen 3.358 N/A HIS 25.A N GLN 21.A O no hydrogen 2.887 N/A GLU 26.A N ASP 22.A O no hydrogen 2.911 N/A ALA 27.A N ARG 24.A O no hydrogen 3.444 N/A CYS 32.A SG PHE 30.A O no hydrogen 3.899 N/A CYS 32.A SG SER 50.A O no hydrogen 3.882 N/A CYS 32.A SG PRO 51.A O no hydrogen 3.207 N/A ARG 33.A N ASP 53.A OD2 no hydrogen 2.841 N/A VAL 34.A N ASP 53.A OD1 no hydrogen 3.045 N/A LYS 36.A N CYS 32.A O no hydrogen 3.237 N/A LYS 36.A NZ ARG 47.A O no hydrogen 2.892 N/A LEU 37.A N VAL 34.A O no hydrogen 3.061 N/A ASN 40.A N LEU 37.A O no hydrogen 2.900 N/A ASN 40.A ND2 VAL 34.A O no hydrogen 2.918 N/A LYS 41.A N PRO 38.A O no hydrogen 3.153 N/A ARG 43.A N ASN 40.A O no hydrogen 2.899 N/A ARG 43.A NH1 TYR 65.A O no hydrogen 2.932 N/A ASN 44.A N LYS 41.A O no hydrogen 3.260 N/A ASN 44.A ND2 ALA 35.A O no hydrogen 2.933 N/A ARG 45.A N GLN 84.A OE1 no hydrogen 2.831 N/A ARG 45.A NE GLY 85.A O no hydrogen 2.913 N/A ARG 45.A NH2 GLY 85.A O no hydrogen 3.101 N/A ARG 45.A NH2 PRO 86.A O no hydrogen 2.810 N/A TYR 46.A OH SER 215.A OG no hydrogen 2.635 N/A ARG 47.A NE ASP 48.A OD1 no hydrogen 3.091 N/A ARG 47.A NH1 ASP 48.A OD1 no hydrogen 3.568 N/A ARG 47.A NH1 ASP 48.A OD2 no hydrogen 3.537 N/A VAL 49.A N TYR 46.A O no hydrogen 3.234 N/A ASP 53.A N PRO 31.A O no hydrogen 2.864 N/A HIS 54.A NE2 LYS 254.A O no hydrogen 2.822 N/A SER 55.A OG PHE 255.A O no hydrogen 2.606 N/A ARG 56.A NH1 ASP 64.A OD1 no hydrogen 2.897 N/A ARG 56.A NH2 ASP 64.A OD1 no hydrogen 3.125 N/A ARG 56.A NH2 ASP 64.A OD2 no hydrogen 3.262 N/A ILE 57.A N ALA 68.A O no hydrogen 3.036 N/A LEU 59.A N ASP 64.A O no hydrogen 2.899 N/A HIS 60.A N GLU 100.A OE1 no hydrogen 2.878 N/A ASN 63.A ND2 ASN 40.A OD1 no hydrogen 2.819 N/A TYR 65.A N ASN 63.A OD1 no hydrogen 2.992 N/A TYR 65.A OH ASN 44.A OD1 no hydrogen 2.586 N/A ASN 67.A ND2 ASN 44.A OD1 no hydrogen 2.972 N/A ASN 67.A ND2 VAL 49.A O no hydrogen 2.899 N/A SER 69.A N LEU 82.A O no hydrogen 2.855 N/A LEU 70.A N SER 55.A O no hydrogen 2.837 N/A ILE 71.A N TYR 80.A O no hydrogen 2.725 N/A MET 73.A N ARG 78.A O no hydrogen 3.056 N/A GLN 77.A N GLU 74.A O no hydrogen 3.296 N/A ARG 78.A N MET 73.A O no hydrogen 3.335 N/A ARG 78.A NH1 ASP 228.A OD2 no hydrogen 2.909 N/A TYR 80.A N ILE 71.A O no hydrogen 3.009 N/A TYR 80.A OH ASP 228.A OD2 no hydrogen 2.523 N/A TYR 80.A OH THR 229.A OG1 no hydrogen 2.884 N/A ILE 81.A N VAL 210.A O no hydrogen 2.884 N/A LEU 82.A N SER 69.A O no hydrogen 2.947 N/A THR 83.A N VAL 212.A O no hydrogen 3.103 N/A THR 83.A OG1 ASN 67.A O no hydrogen 2.654 N/A THR 83.A OG1 GLN 84.A O no hydrogen 3.565 N/A GLN 84.A N ASN 67.A O no hydrogen 3.377 N/A GLN 84.A NE2 ARG 43.A O no hydrogen 2.926 N/A GLY 85.A N SER 215.A O no hydrogen 2.785 N/A LEU 87.A N THR 90.A OG1 no hydrogen 2.823 N/A ASN 89.A ND2 ASN 42.A O no hydrogen 3.051 N/A THR 90.A N LEU 87.A O no hydrogen 2.917 N/A THR 90.A OG1 LEU 87.A O no hydrogen 3.512 N/A CYS 91.A SG LEU 87.A O no hydrogen 3.340 N/A PHE 94.A N THR 90.A O no hydrogen 2.851 N/A TRP 95.A N CYS 91.A O no hydrogen 3.116 N/A TRP 95.A NE1 TYR 123.A O no hydrogen 2.918 N/A GLU 96.A N GLY 92.A O no hydrogen 2.840 N/A MET 97.A N HIS 93.A O no hydrogen 2.878 N/A VAL 98.A N PHE 94.A O no hydrogen 2.992 N/A TRP 99.A N TRP 95.A O no hydrogen 2.848 N/A GLU 100.A N GLU 96.A O no hydrogen 2.813 N/A GLN 101.A N MET 97.A O no hydrogen 2.874 N/A LYS 102.A N TRP 99.A O no hydrogen 3.069 N/A SER 103.A N VAL 98.A O no hydrogen 3.252 N/A SER 103.A OG PRO 209.A O no hydrogen 2.688 N/A ARG 104.A NH1 LYS 102.A O no hydrogen 3.095 N/A VAL 106.A N LEU 171.A O no hydrogen 2.839 N/A VAL 107.A N VAL 211.A O no hydrogen 2.691 N/A MET 108.A N PHE 173.A O no hydrogen 2.814 N/A LEU 109.A N HIS 213.A O no hydrogen 2.926 N/A ASN 110.A ND2 ARG 111.A O no hydrogen 2.939 N/A ARG 111.A N GLU 114.A OE1 no hydrogen 2.847 N/A ARG 111.A NE GLY 176.A O no hydrogen 2.449 N/A ARG 111.A NH2 GLY 176.A O no hydrogen 3.216 N/A GLU 114.A N SER 117.A O no hydrogen 2.979 N/A LYS 115.A NZ ASP 180.A OD1 no hydrogen 2.705 N/A LYS 115.A NZ ASP 180.A OD2 no hydrogen 3.517 N/A SER 117.A N GLU 114.A O no hydrogen 3.029 N/A LYS 119.A N VAL 112.A O no hydrogen 2.773 N/A CYS 120.A SG ALA 121.A O no hydrogen 3.437 N/A ALA 121.A N PRO 86.A O no hydrogen 2.863 N/A GLN 122.A NE2 TRP 124.A O no hydrogen 2.898 N/A TYR 123.A OH HIS 172.A NE2 no hydrogen 2.791 N/A TYR 123.A OH HIS 213.A NE2 no hydrogen 2.633 N/A GLU 128.A N GLU 128.A OE1 no hydrogen 2.685 N/A GLU 129.A N GLU 129.A OE1 no hydrogen 2.639 N/A LYS 130.A N LYS 127.A O no hydrogen 3.049 N/A GLU 131.A N GLU 131.A OE1 no hydrogen 2.727 N/A MET 132.A N LEU 141.A O no hydrogen 2.872 N/A PHE 134.A N LEU 139.A O no hydrogen 2.719 N/A THR 137.A OG1 GLY 92.A O no hydrogen 3.399 N/A ASN 138.A ND2 THR 163.A OG1 no hydrogen 2.521 N/A LEU 139.A N PHE 134.A O no hydrogen 3.231 N/A LYS 140.A N GLU 160.A O no hydrogen 2.965 N/A LEU 141.A N MET 132.A O no hydrogen 2.747 N/A THR 142.A N GLU 158.A O no hydrogen 2.960 N/A ILE 144.A N GLN 156.A O no hydrogen 2.814 N/A SER 145.A N GLN 156.A O no hydrogen 3.376 N/A SER 145.A OG GLN 156.A OE1 no hydrogen 3.208 N/A ASP 147.A N VAL 154.A O no hydrogen 2.734 N/A LYS 149.A N TYR 152.A O no hydrogen 2.788 N/A LYS 149.A NZ ASP 297.A OD1 no hydrogen 3.058 N/A SER 150.A N GLU 296.A O no hydrogen 2.734 N/A SER 150.A OG HIS 295.A O no hydrogen 2.666 N/A TYR 151.A OH SER 189.A O no hydrogen 2.686 N/A TYR 152.A OH GLU 296.A OE1 no hydrogen 2.592 N/A THR 153.A N HIS 174.A O no hydrogen 2.910 N/A VAL 154.A N ASP 147.A O no hydrogen 2.944 N/A ARG 155.A N HIS 172.A O no hydrogen 2.811 N/A ARG 155.A NE GLU 146.A OE1 no hydrogen 2.912 N/A ARG 155.A NH1 HIS 172.A ND1 no hydrogen 2.984 N/A ARG 155.A NH1 HIS 174.A ND1 no hydrogen 2.989 N/A ARG 155.A NH2 HIS 174.A ND1 no hydrogen 3.410 N/A GLN 156.A N SER 145.A O no hydrogen 2.841 N/A LEU 157.A N ILE 170.A O no hydrogen 2.844 N/A GLU 158.A N THR 142.A O no hydrogen 2.879 N/A LEU 159.A N ARG 168.A O no hydrogen 2.881 N/A GLU 160.A N LYS 140.A O no hydrogen 2.833 N/A ASN 161.A N GLU 166.A O no hydrogen 2.919 N/A LEU 162.A N ASN 138.A O no hydrogen 2.888 N/A THR 163.A N ASN 161.A OD1 no hydrogen 3.098 N/A THR 164.A N ASN 161.A O no hydrogen 3.259 N/A GLN 165.A N ASN 161.A O no hydrogen 2.633 N/A GLU 166.A N THR 164.A OG1 no hydrogen 3.271 N/A ARG 168.A N LEU 159.A O no hydrogen 2.827 N/A ARG 168.A NE GLU 166.A OE2 no hydrogen 2.956 N/A ARG 168.A NH1 TRP 99.A O no hydrogen 2.865 N/A ARG 168.A NH2 GLU 166.A OE2 no hydrogen 3.391 N/A ILE 170.A N LEU 157.A O no hydrogen 2.877 N/A LEU 171.A N ARG 104.A O no hydrogen 2.976 N/A HIS 172.A N ARG 155.A O no hydrogen 2.867 N/A HIS 172.A NE2 TYR 123.A OH no hydrogen 2.791 N/A PHE 173.A N VAL 106.A O no hydrogen 2.862 N/A HIS 174.A N THR 153.A O no hydrogen 2.828 N/A HIS 174.A NE2 ASN 110.A O no hydrogen 2.785 N/A TYR 175.A N MET 108.A O no hydrogen 2.798 N/A GLY 176.A N TYR 151.A O no hydrogen 2.853 N/A TRP 178.A NE1 THR 182.A O no hydrogen 2.873 N/A GLN 181.A NE2 ASP 180.A OD2 no hydrogen 2.960 N/A THR 182.A OG1 PRO 179.A O no hydrogen 2.833 N/A THR 182.A OG1 ALA 183.A O no hydrogen 3.366 N/A SER 186.A OG SER 189.A OG no hydrogen 2.981 N/A SER 189.A N SER 186.A OG no hydrogen 2.874 N/A SER 189.A OG SER 186.A OG no hydrogen 2.981 N/A PHE 190.A N SER 186.A O no hydrogen 3.164 N/A LEU 191.A N PRO 187.A O no hydrogen 2.764 N/A ASN 192.A N ALA 188.A O no hydrogen 2.810 N/A ASN 192.A ND2 TYR 151.A OH no hydrogen 2.983 N/A ASN 192.A ND2 GLU 296.A OE1 no hydrogen 2.854 N/A PHE 193.A N SER 189.A O no hydrogen 3.188 N/A LEU 194.A N PHE 190.A O no hydrogen 2.836 N/A PHE 195.A N LEU 191.A O no hydrogen 2.859 N/A LYS 196.A N ASN 192.A O no hydrogen 3.034 N/A LYS 196.A NZ TYR 152.A OH no hydrogen 3.143 N/A VAL 197.A N PHE 193.A O no hydrogen 3.042 N/A ARG 198.A N LEU 194.A O no hydrogen 2.945 N/A ARG 198.A NE ASP 228.A OD1 no hydrogen 2.808 N/A ARG 198.A NH2 ASP 228.A O no hydrogen 3.401 N/A ARG 198.A NH2 ASP 228.A OD1 no hydrogen 2.964 N/A GLU 199.A N PHE 195.A O no hydrogen 2.837 N/A SER 200.A N LYS 196.A O no hydrogen 3.184 N/A SER 200.A N VAL 197.A O no hydrogen 3.254 N/A SER 200.A OG VAL 197.A O no hydrogen 2.723 N/A SER 200.A OG SER 202.A OG no hydrogen 2.508 N/A GLY 201.A N ARG 198.A O no hydrogen 3.171 N/A SER 202.A N SER 200.A OG no hydrogen 2.959 N/A SER 202.A OG SER 200.A OG no hydrogen 2.508 N/A SER 204.A N GLY 201.A O no hydrogen 3.101 N/A GLU 206.A N SER 204.A OG no hydrogen 3.065 N/A HIS 207.A N SER 204.A O no hydrogen 3.140 N/A GLY 208.A N LYS 102.A O no hydrogen 2.922 N/A VAL 211.A N GLY 105.A O no hydrogen 3.094 N/A VAL 212.A N ILE 81.A O no hydrogen 2.725 N/A HIS 213.A N VAL 107.A O no hydrogen 2.859 N/A HIS 213.A ND1 CYS 214.A O no hydrogen 2.846 N/A HIS 213.A NE2 TYR 123.A OH no hydrogen 2.633 N/A CYS 214.A SG SER 221.A OG no hydrogen 3.124 N/A SER 215.A OG TYR 46.A OH no hydrogen 2.635 N/A SER 215.A OG LYS 119.A O no hydrogen 2.849 N/A ARG 220.A NH1 GLU 114.A OE1 no hydrogen 2.847 N/A ARG 220.A NH1 GLU 114.A OE2 no hydrogen 3.394 N/A ARG 220.A NH1 TRP 178.A O no hydrogen 2.759 N/A ARG 220.A NH2 GLU 114.A OE2 no hydrogen 3.076 N/A GLY 222.A N ILE 218.A O no hydrogen 3.098 N/A THR 223.A N GLY 219.A O no hydrogen 3.013 N/A THR 223.A OG1 GLY 219.A O no hydrogen 2.923 N/A PHE 224.A N ARG 220.A O no hydrogen 2.981 N/A CYS 225.A N.A SER 221.A O no hydrogen 3.115 N/A CYS 225.A N.B SER 221.A O no hydrogen 3.083 N/A CYS 225.A SG.A SER 221.A O no hydrogen 3.521 N/A LEU 226.A N GLY 222.A O no hydrogen 2.898 N/A ALA 227.A N THR 223.A O no hydrogen 3.141 N/A ASP 228.A N PHE 224.A O no hydrogen 3.130 N/A THR 229.A N CYS 225.A O.A no hydrogen 2.915 N/A THR 229.A N CYS 225.A O.B no hydrogen 2.883 N/A THR 229.A OG1 TYR 80.A OH no hydrogen 2.884 N/A THR 229.A OG1 CYS 225.A O.A no hydrogen 3.066 N/A THR 229.A OG1 CYS 225.A O.B no hydrogen 3.196 N/A CYS 230.A N LEU 226.A O no hydrogen 2.968 N/A CYS 230.A SG LEU 226.A O no hydrogen 3.349 N/A LEU 231.A N ALA 227.A O no hydrogen 3.053 N/A LEU 232.A N ASP 228.A O no hydrogen 2.927 N/A LEU 233.A N THR 229.A O no hydrogen 2.863 N/A MET 234.A N CYS 230.A O no hydrogen 3.118 N/A ASP 235.A N LEU 231.A O no hydrogen 2.878 N/A LYS 236.A N LEU 232.A O no hydrogen 2.918 N/A ARG 237.A N LEU 233.A O no hydrogen 3.253 N/A ARG 237.A NH1 SER 242.A O no hydrogen 2.749 N/A ARG 237.A NH1 SER 242.A OG no hydrogen 2.625 N/A ARG 237.A NH2 GLU 75.A OE2 no hydrogen 2.256 N/A LYS 238.A N ASP 235.A O no hydrogen 3.199 N/A LYS 238.A NZ ASP 235.A O no hydrogen 2.955 N/A LYS 238.A NZ ASP 235.A OD1 no hydrogen 2.871 N/A ASP 239.A N MET 234.A O no hydrogen 3.159 N/A SER 241.A OG ASP 239.A OD1 no hydrogen 2.487 N/A SER 242.A N ASP 239.A O no hydrogen 3.163 N/A SER 242.A OG ASP 239.A O no hydrogen 2.717 N/A VAL 243.A N PRO 240.A O no hydrogen 3.267 N/A LYS 246.A NZ GLU 6.A OE1 no hydrogen 3.462 N/A LYS 246.A NZ GLU 6.A OE2 no hydrogen 2.683 N/A LYS 247.A N ASP 244.A OD1 no hydrogen 3.373 N/A VAL 248.A N ASP 244.A O no hydrogen 2.978 N/A LEU 249.A N ILE 245.A O no hydrogen 2.918 N/A LEU 250.A N LYS 246.A O no hydrogen 2.935 N/A GLU 251.A N LYS 247.A O no hydrogen 2.981 N/A MET 252.A N VAL 248.A O no hydrogen 2.905 N/A ARG 253.A N LEU 249.A O no hydrogen 2.925 N/A ARG 253.A NE LEU 259.A O no hydrogen 2.923 N/A ARG 253.A NH2 LEU 259.A O no hydrogen 2.967 N/A ARG 253.A NH2 ILE 260.A O no hydrogen 2.892 N/A LYS 254.A N GLU 251.A O no hydrogen 2.994 N/A LYS 254.A NZ GLU 251.A OE2 no hydrogen 2.800 N/A PHE 255.A N MET 252.A O no hydrogen 2.930 N/A ARG 256.A NE GLY 217.A O no hydrogen 2.962 N/A ARG 256.A NH1 ASN 67.A OD1 no hydrogen 3.170 N/A ARG 256.A NH1 SER 69.A OG no hydrogen 3.019 N/A ARG 256.A NH2 ASN 67.A OD1 no hydrogen 3.043 N/A ARG 256.A NH2 ALA 216.A O no hydrogen 2.923 N/A ILE 260.A N ILE 218.A O no hydrogen 2.865 N/A GLN 261.A N GLN 265.A OE1 no hydrogen 2.830 N/A GLN 261.A NE2 GLY 258.A O no hydrogen 2.755 N/A GLN 265.A N THR 262.A OG1 no hydrogen 3.022 N/A GLN 265.A NE2 THR 182.A O no hydrogen 3.021 N/A LEU 266.A N THR 262.A O no hydrogen 3.173 N/A ARG 267.A N ALA 263.A O no hydrogen 2.877 N/A ARG 267.A NE ASP 11.A OD1 no hydrogen 3.025 N/A ARG 267.A NH2 ASP 11.A OD2 no hydrogen 3.002 N/A PHE 268.A N ASP 264.A O no hydrogen 2.793 N/A SER 269.A N GLN 265.A O no hydrogen 3.028 N/A SER 269.A OG GLN 265.A O no hydrogen 2.858 N/A TYR 270.A N LEU 266.A O no hydrogen 3.259 N/A TYR 270.A OH GLU 6.A OE1 no hydrogen 2.743 N/A LEU 271.A N ARG 267.A O no hydrogen 3.142 N/A ALA 272.A N PHE 268.A O no hydrogen 2.800 N/A VAL 273.A N SER 269.A O no hydrogen 2.936 N/A ILE 274.A N TYR 270.A O no hydrogen 2.854 N/A GLU 275.A N LEU 271.A O no hydrogen 3.005 N/A GLY 276.A N ALA 272.A O no hydrogen 2.781 N/A ALA 277.A N VAL 273.A O no hydrogen 2.862 N/A LYS 278.A N GLU 275.A O no hydrogen 3.091 N/A LYS 278.A NZ GLU 275.A OE1 no hydrogen 2.960 N/A PHE 279.A N GLY 276.A O no hydrogen 2.966 N/A ILE 280.A N GLY 276.A O no hydrogen 3.142 N/A MET 281.A N ALA 277.A O no hydrogen 2.954 N/A GLY 282.A N PHE 279.A O no hydrogen 2.983 N/A ASP 283.A N LYS 278.A O no hydrogen 3.003 N/A SER 285.A OG ASP 283.A OD1 no hydrogen 3.218 N/A VAL 286.A N ASP 283.A O no hydrogen 3.123 N/A GLN 287.A N SER 284.A O no hydrogen 3.189 N/A GLN 287.A NE2 GLU 199.A OE1 no hydrogen 2.955 N/A ASP 288.A N SER 285.A O no hydrogen 3.002 N/A GLN 289.A N SER 285.A O no hydrogen 3.346 N/A TRP 290.A N VAL 286.A O no hydrogen 2.969 N/A TRP 290.A NE1 GLU 275.A OE2 no hydrogen 2.918 N/A LYS 291.A N GLN 287.A O no hydrogen 3.143 N/A LYS 291.A NZ GLU 296.A OE2 no hydrogen 3.050 N/A GLU 292.A N ASP 288.A O no hydrogen 3.089 N/A LEU 293.A N GLN 289.A O no hydrogen 2.842 N/A SER 294.A N TRP 290.A O no hydrogen 2.861 N/A SER 294.A OG LYS 291.A O no hydrogen 2.933 N/A HIS 295.A N GLU 292.A O no hydrogen 3.172 N/A