Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7akv_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): CYS 2.A SG PRO 3.A O no hydrogen 4.027 N/A CYS 9.A SG SER 10.A O no hydrogen 3.579 N/A LEU 12.A N SER 10.A OG no hydrogen 3.362 N/A SER 14.A N ASP 11.A O no hydrogen 3.066 N/A SER 16.A OG GLU 13.A OE1 no hydrogen 2.005 N/A THR 17.A OG1 GLU 13.A O no hydrogen 3.342 N/A LEU 21.A N THR 17.A O no hydrogen 2.726 N/A GLY 22.A N GLU 18.A O no hydrogen 2.874 N/A ASP 23.A N ALA 19.A O no hydrogen 2.969 N/A ALA 24.A N VAL 20.A O no hydrogen 2.914 N/A LEU 25.A N LEU 21.A O no hydrogen 2.855 N/A VAL 26.A N GLY 22.A O no hydrogen 2.936 N/A ASP 27.A N ASP 23.A O no hydrogen 2.969 N/A PHE 28.A N ALA 24.A O no hydrogen 2.873 N/A SER 29.A N LEU 25.A O no hydrogen 2.824 N/A SER 29.A OG LEU 25.A O no hydrogen 3.499 N/A SER 29.A OG VAL 26.A O no hydrogen 2.635 N/A LEU 30.A N VAL 26.A O no hydrogen 2.987 N/A LYS 31.A N ASP 27.A O no hydrogen 2.982 N/A LEU 32.A N PHE 28.A O no hydrogen 2.856 N/A TYR 33.A N SER 29.A O no hydrogen 2.860 N/A HIS 34.A N LEU 30.A O no hydrogen 2.966 N/A ALA 35.A N LYS 31.A O no hydrogen 2.987 N/A PHE 36.A N LEU 32.A O no hydrogen 2.866 N/A SER 37.A N TYR 33.A O no hydrogen 2.870 N/A SER 37.A OG TYR 33.A O no hydrogen 2.900 N/A SER 37.A OG HIS 34.A O no hydrogen 2.729 N/A ALA 38.A N HIS 34.A O no hydrogen 2.942 N/A MET 39.A N ALA 35.A O no hydrogen 2.928 N/A LYS 40.A N PHE 36.A O no hydrogen 2.826 N/A THR 44.A OG1 LYS 41.A O no hydrogen 2.519 N/A MET 46.A N ARG 373.A O no hydrogen 2.934 N/A ALA 47.A N THR 284.A OG1 no hydrogen 3.292 N/A PHE 48.A N MET 371.A O no hydrogen 2.925 N/A SER 49.A OG SER 52.A OG no hydrogen 3.092 N/A SER 49.A OG VAL 369.A O no hydrogen 3.192 N/A PHE 51.A N VAL 369.A O no hydrogen 3.399 N/A SER 52.A OG SER 49.A OG no hydrogen 3.092 N/A ILE 53.A N SER 49.A O no hydrogen 3.018 N/A ALA 54.A N PRO 50.A O no hydrogen 2.870 N/A SER 55.A N PHE 51.A O no hydrogen 2.898 N/A LEU 56.A N SER 52.A O no hydrogen 2.929 N/A LEU 57.A N ILE 53.A O no hydrogen 2.904 N/A THR 58.A N ALA 54.A O no hydrogen 2.842 N/A THR 58.A OG1 ALA 54.A O no hydrogen 3.235 N/A THR 58.A OG1 SER 55.A O no hydrogen 2.274 N/A GLN 59.A N SER 55.A O no hydrogen 2.918 N/A VAL 60.A N LEU 56.A O no hydrogen 2.975 N/A LEU 61.A N LEU 57.A O no hydrogen 2.850 N/A LEU 62.A N THR 58.A O no hydrogen 2.863 N/A GLY 63.A N GLN 59.A O no hydrogen 2.955 N/A ALA 64.A N LEU 61.A O no hydrogen 2.459 N/A GLY 65.A N ASN 305.A O no hydrogen 3.183 N/A THR 68.A OG1 ASP 299.A OD2 no hydrogen 2.643 N/A THR 70.A N GLU 66.A O no hydrogen 2.915 N/A THR 70.A OG1 ASN 67.A O no hydrogen 2.691 N/A ASN 71.A N ASN 67.A O no hydrogen 2.936 N/A ASN 71.A ND2 ASN 67.A OD1 no hydrogen 3.212 N/A LEU 72.A N THR 68.A O no hydrogen 2.888 N/A GLU 73.A N LYS 69.A O no hydrogen 2.872 N/A SER 74.A N THR 70.A O no hydrogen 2.928 N/A SER 74.A OG THR 70.A O no hydrogen 3.166 N/A SER 74.A OG ASN 71.A O no hydrogen 2.424 N/A ILE 75.A N ASN 71.A O no hydrogen 2.923 N/A LEU 76.A N LEU 72.A O no hydrogen 2.896 N/A SER 77.A N SER 74.A O no hydrogen 2.882 N/A SER 77.A OG LEU 76.A O no hydrogen 2.262 N/A TYR 78.A N GLU 73.A O no hydrogen 3.084 N/A VAL 85.A N PHE 82.A O no hydrogen 3.214 N/A HIS 86.A N THR 83.A O no hydrogen 2.964 N/A HIS 86.A ND1 THR 83.A O no hydrogen 3.100 N/A ALA 88.A N CYS 84.A O no hydrogen 2.239 N/A LEU 89.A N VAL 85.A O no hydrogen 2.281 N/A LYS 90.A N HIS 86.A O no hydrogen 3.136 N/A LYS 90.A NZ THR 93.A OG1 no hydrogen 3.173 N/A GLY 91.A N GLN 87.A O no hydrogen 3.171 N/A PHE 92.A N ALA 88.A O no hydrogen 3.298 N/A THR 93.A N LEU 89.A O no hydrogen 3.279 N/A THR 93.A N LYS 90.A O no hydrogen 3.058 N/A THR 93.A OG1 LEU 89.A O no hydrogen 3.534 N/A THR 93.A OG1 LYS 90.A O no hydrogen 3.398 N/A THR 98.A N TYR 173.A O no hydrogen 2.938 N/A THR 98.A OG1 TYR 173.A O no hydrogen 3.331 N/A VAL 100.A N ALA 171.A O no hydrogen 2.868 N/A GLN 102.A N LEU 169.A O no hydrogen 2.902 N/A ILE 103.A N GLN 102.A OE1 no hydrogen 3.304 N/A PHE 104.A N VAL 167.A O no hydrogen 2.892 N/A HIS 105.A N ARG 128.A O no hydrogen 3.231 N/A HIS 105.A ND1 ARG 128.A O no hydrogen 2.612 N/A SER 106.A N ARG 165.A O no hydrogen 3.242 N/A LEU 109.A N SER 106.A OG no hydrogen 2.903 N/A ARG 112.A NE GLU 311.A OE2 no hydrogen 2.227 N/A VAL 116.A N ARG 112.A O no hydrogen 3.180 N/A ASN 117.A N ASP 113.A O no hydrogen 2.894 N/A ALA 118.A N THR 114.A O no hydrogen 2.941 N/A SER 119.A N PHE 115.A O no hydrogen 2.871 N/A SER 119.A OG PHE 115.A O no hydrogen 2.643 N/A SER 119.A OG VAL 116.A O no hydrogen 2.791 N/A ARG 120.A N VAL 116.A O no hydrogen 2.920 N/A THR 121.A N ASN 117.A O no hydrogen 2.900 N/A THR 121.A OG1 ASN 117.A O no hydrogen 3.318 N/A THR 121.A OG1 ALA 118.A O no hydrogen 2.308 N/A LEU 122.A N ALA 118.A O no hydrogen 2.922 N/A SER 125.A OG TYR 123.A O no hydrogen 3.369 N/A LEU 130.A N HIS 105.A O no hydrogen 2.472 N/A SER 131.A N ASN 137.A OD1 no hydrogen 2.291 N/A SER 131.A OG ASN 133.A O no hydrogen 3.085 N/A SER 131.A OG ASN 137.A OD1 no hydrogen 2.845 N/A ALA 136.A N ASP 135.A OD1 no hydrogen 2.420 N/A ASN 137.A ND2 SER 131.A O no hydrogen 2.832 N/A LEU 138.A N SER 134.A O no hydrogen 2.628 N/A GLU 139.A N ASP 135.A O no hydrogen 2.972 N/A LEU 140.A N ALA 136.A O no hydrogen 2.875 N/A ILE 141.A N ASN 137.A O no hydrogen 2.865 N/A ASN 142.A N LEU 138.A O no hydrogen 2.969 N/A ASN 142.A ND2 LEU 138.A O no hydrogen 2.872 N/A ASN 142.A ND2 LEU 157.A O no hydrogen 2.461 N/A THR 143.A N GLU 139.A O no hydrogen 2.924 N/A THR 143.A OG1 GLU 139.A O no hydrogen 2.949 N/A THR 143.A OG1 LEU 140.A O no hydrogen 2.730 N/A TRP 144.A N LEU 140.A O no hydrogen 2.851 N/A VAL 145.A N ILE 141.A O no hydrogen 2.995 N/A ALA 146.A N ASN 142.A O no hydrogen 2.885 N/A LYS 147.A N THR 143.A O no hydrogen 2.915 N/A LYS 147.A NZ ASN 148.A OD1 no hydrogen 2.789 N/A ASN 148.A N TRP 144.A O no hydrogen 2.946 N/A ASN 148.A N VAL 145.A O no hydrogen 3.310 N/A THR 149.A OG1 VAL 145.A O no hydrogen 3.412 N/A ASN 151.A N ALA 146.A O no hydrogen 2.833 N/A LYS 152.A N THR 149.A O no hydrogen 2.977 N/A LYS 152.A NZ TYR 173.A OH no hydrogen 3.403 N/A ILE 153.A N THR 149.A OG1 no hydrogen 3.206 N/A ARG 155.A NH1 ASP 158.A OD1 no hydrogen 2.378 N/A LEU 157.A N ASN 142.A OD1 no hydrogen 3.028 N/A LEU 160.A N ASP 158.A O no hydrogen 2.801 N/A THR 164.A OG1 PRO 161.A O no hydrogen 3.257 N/A ARG 165.A NH1 ASP 108.A OD2 no hydrogen 3.345 N/A LEU 166.A N SER 318.A OG no hydrogen 3.047 N/A VAL 167.A N PHE 104.A O no hydrogen 2.895 N/A LEU 169.A N GLN 102.A O no hydrogen 2.936 N/A ALA 171.A N VAL 100.A O no hydrogen 2.914 N/A ILE 172.A N GLN 323.A O no hydrogen 3.018 N/A TYR 173.A N THR 98.A O no hydrogen 2.929 N/A LEU 174.A N VAL 325.A O no hydrogen 3.167 N/A SER 175.A N GLY 96.A O no hydrogen 2.589 N/A SER 175.A OG GLY 96.A O no hydrogen 2.177 N/A LYS 177.A N SER 229.A OG no hydrogen 2.571 N/A LYS 179.A N GLN 227.A O no hydrogen 3.493 N/A THR 180.A N TYR 209.A OH no hydrogen 3.204 N/A THR 181.A N GLU 334.A O no hydrogen 2.729 N/A LYS 185.A NZ ASP 183.A OD1 no hydrogen 3.114 N/A LYS 186.A N ASP 183.A OD2 no hydrogen 2.187 N/A THR 187.A N PRO 184.A O no hydrogen 2.834 N/A THR 187.A OG1 MET 203.A O no hydrogen 3.265 N/A ARG 188.A N MET 203.A O no hydrogen 2.903 N/A GLU 190.A N VAL 201.A O no hydrogen 2.920 N/A PHE 192.A N ILE 199.A O no hydrogen 2.890 N/A HIS 193.A N GLN 353.A O no hydrogen 3.037 N/A ILE 199.A N PHE 192.A O no hydrogen 2.955 N/A VAL 201.A N GLU 190.A O no hydrogen 2.906 N/A MET 203.A N ARG 188.A O no hydrogen 2.903 N/A MET 204.A N LEU 277.A O no hydrogen 2.870 N/A SER 206.A N LEU 275.A O no hydrogen 2.865 N/A TYR 209.A OH THR 180.A O no hydrogen 2.544 N/A VAL 211.A N GLN 271.A O no hydrogen 3.190 N/A ALA 212.A N GLN 225.A O no hydrogen 2.959 N/A PHE 214.A N VAL 223.A O no hydrogen 2.971 N/A ASP 216.A N ALA 221.A O no hydrogen 2.896 N/A THR 218.A OG1 ASP 216.A OD2 no hydrogen 2.245 N/A LEU 219.A N ASP 216.A OD2 no hydrogen 3.396 N/A ALA 221.A N ASP 216.A O no hydrogen 2.921 N/A LYS 222.A N VAL 238.A O no hydrogen 2.906 N/A LYS 222.A NZ GLU 351.A O no hydrogen 3.513 N/A VAL 223.A N PHE 214.A O no hydrogen 2.873 N/A GLY 224.A N ILE 236.A O no hydrogen 2.921 N/A GLN 225.A N ALA 212.A O no hydrogen 2.856 N/A LEU 226.A N LEU 234.A O no hydrogen 2.906 N/A LEU 228.A N GLN 227.A OE1 no hydrogen 3.069 N/A LEU 228.A N LEU 232.A O no hydrogen 2.870 N/A SER 229.A N LYS 177.A O no hydrogen 2.653 N/A SER 229.A OG LYS 177.A O no hydrogen 3.151 N/A SER 233.A N TRP 361.A O no hydrogen 2.904 N/A SER 233.A OG TRP 361.A O no hydrogen 3.310 N/A LEU 234.A N LEU 226.A O no hydrogen 2.879 N/A VAL 235.A N VAL 359.A O no hydrogen 2.884 N/A ILE 236.A N GLY 224.A O no hydrogen 2.890 N/A LEU 237.A N LEU 357.A O no hydrogen 2.839 N/A VAL 238.A N LYS 222.A O no hydrogen 2.919 N/A GLN 240.A N LYS 220.A O no hydrogen 3.305 N/A GLN 240.A NE2 GLN 217.A OE1 no hydrogen 3.367 N/A LYS 243.A N ASN 241.A OD1 no hydrogen 2.587 N/A HIS 244.A N ASN 241.A OD1 no hydrogen 2.551 N/A ARG 245.A N ASP 248.A OD2 no hydrogen 2.900 N/A GLU 247.A N GLU 247.A OE1 no hydrogen 2.643 N/A ASP 248.A N ARG 245.A O no hydrogen 2.649 N/A MET 249.A N ARG 245.A O no hydrogen 3.380 N/A GLU 250.A N LEU 246.A O no hydrogen 2.895 N/A GLN 251.A N GLU 247.A O no hydrogen 2.910 N/A ALA 252.A N ASP 248.A O no hydrogen 2.896 N/A LEU 253.A N GLU 250.A O no hydrogen 3.101 N/A VAL 257.A N SER 254.A OG no hydrogen 3.389 N/A PHE 258.A N SER 254.A O no hydrogen 2.849 N/A LYS 259.A N PRO 255.A O no hydrogen 2.902 N/A ALA 260.A N SER 256.A O no hydrogen 2.935 N/A ILE 261.A N VAL 257.A O no hydrogen 2.922 N/A MET 262.A N PHE 258.A O no hydrogen 2.898 N/A GLU 263.A N LYS 259.A O no hydrogen 2.948 N/A LYS 264.A N ALA 260.A O no hydrogen 2.916 N/A LEU 265.A N ILE 261.A O no hydrogen 2.900 N/A GLU 266.A N MET 262.A O no hydrogen 2.892 N/A MET 267.A N GLU 263.A O no hydrogen 2.965 N/A SER 268.A N LEU 265.A O no hydrogen 2.694 N/A SER 268.A OG LYS 264.A O no hydrogen 3.128 N/A THR 273.A OG1 GLN 271.A O no hydrogen 3.531 N/A THR 273.A OG1 PRO 272.A O no hydrogen 2.353 N/A THR 273.A OG1 LEU 348.A O no hydrogen 2.606 N/A LEU 275.A N SER 206.A O no hydrogen 2.896 N/A THR 276.A N PHE 350.A O no hydrogen 2.922 N/A THR 276.A OG1 ASN 205.A OD1 no hydrogen 3.475 N/A LEU 277.A N MET 204.A O no hydrogen 2.984 N/A VAL 282.A N LEU 326.A O no hydrogen 2.889 N/A THR 284.A N THR 324.A O no hydrogen 2.932 N/A THR 284.A OG1 THR 283.A O no hydrogen 2.657 N/A SER 285.A OG GLN 321.A OE1 no hydrogen 3.366 N/A GLN 286.A N HIS 322.A O no hydrogen 2.888 N/A GLN 286.A NE2 SER 290.A OG no hydrogen 3.291 N/A MET 288.A N MET 320.A O no hydrogen 3.068 N/A LEU 289.A N ASP 287.A OD1 no hydrogen 2.475 N/A SER 290.A OG ASP 287.A O no hydrogen 3.360 N/A MET 292.A N MET 288.A O no hydrogen 2.690 N/A GLU 293.A N LEU 289.A O no hydrogen 2.906 N/A LYS 294.A N SER 290.A O no hydrogen 2.904 N/A LYS 294.A NZ GLU 293.A OE1 no hydrogen 3.232 N/A LEU 295.A N MET 292.A O no hydrogen 3.338 N/A GLU 296.A N GLU 293.A O no hydrogen 3.406 N/A SER 301.A N PHE 298.A O no hydrogen 2.360 N/A SER 301.A OG PHE 298.A O no hydrogen 2.347 N/A TYR 302.A N PHE 298.A O no hydrogen 2.560 N/A ASN 305.A ND2 GLU 66.A OE1 no hydrogen 3.146 N/A CYS 307.A N ASN 305.A OD1 no hydrogen 3.121 N/A LEU 309.A N LEU 306.A O no hydrogen 2.611 N/A THR 310.A N LEU 306.A O no hydrogen 2.872 N/A ASP 314.A N ASP 312.A OD1 no hydrogen 2.458 N/A GLN 316.A NE2 SER 318.A OG no hydrogen 3.264 N/A SER 318.A N LEU 166.A O no hydrogen 2.668 N/A SER 318.A OG LEU 166.A O no hydrogen 2.558 N/A HIS 322.A N GLN 286.A O no hydrogen 2.954 N/A HIS 322.A NE2 THR 324.A OG1 no hydrogen 2.224 N/A GLN 323.A N ASN 170.A O no hydrogen 3.305 N/A THR 324.A N THR 284.A O no hydrogen 2.892 N/A THR 324.A OG1 HIS 322.A NE2 no hydrogen 2.224 N/A VAL 325.A N ILE 172.A O no hydrogen 3.182 N/A LEU 326.A N VAL 282.A O no hydrogen 2.880 N/A LEU 328.A N ILE 280.A O no hydrogen 2.899 N/A THR 329.A OG1 THR 331.A OG1 no hydrogen 3.031 N/A GLU 330.A N GLU 330.A OE1 no hydrogen 3.016 N/A THR 331.A N THR 329.A OG1 no hydrogen 3.416 N/A THR 331.A OG1 THR 329.A OG1 no hydrogen 3.031 N/A GLY 332.A N GLU 330.A O no hydrogen 2.672 N/A VAL 333.A N TRP 178.A O no hydrogen 2.174 N/A ILE 341.A N SER 339.A OG no hydrogen 3.369 N/A SER 342.A N SER 339.A O no hydrogen 3.183 N/A SER 342.A OG SER 339.A O no hydrogen 3.472 N/A PHE 350.A N LEU 274.A O no hydrogen 2.898 N/A VAL 352.A N THR 276.A O no hydrogen 3.313 N/A GLN 353.A NE2 PRO 191.A O no hydrogen 2.634 N/A GLN 354.A NE2 ASN 241.A O no hydrogen 2.804 N/A PHE 356.A N VAL 374.A O no hydrogen 2.963 N/A LEU 357.A N LEU 237.A O no hydrogen 2.972 N/A PHE 358.A N GLY 372.A O no hydrogen 2.907 N/A VAL 359.A N VAL 235.A O no hydrogen 2.904 N/A TRP 361.A N SER 233.A O no hydrogen 2.828 N/A ASP 362.A N PHE 367.A O no hydrogen 3.374 N/A GLN 363.A NE2 GLN 227.A OE1 no hydrogen 3.442 N/A GLN 363.A NE2 ASN 231.A OD1 no hydrogen 3.117 N/A GLN 364.A N ASP 362.A OD1 no hydrogen 3.100 N/A PHE 370.A N LEU 360.A O no hydrogen 3.332 N/A MET 371.A N PHE 48.A O no hydrogen 2.909 N/A GLY 372.A N PHE 358.A O no hydrogen 2.949 N/A ARG 373.A N MET 46.A O no hydrogen 2.911 N/A ARG 373.A NE THR 44.A O no hydrogen 3.402 N/A ARG 373.A NH1 GLU 250.A OE2 no hydrogen 3.170 N/A VAL 374.A N PHE 356.A O no hydrogen 2.934 N/A TYR 375.A OH GLU 247.A OE2 no hydrogen 3.115 N/A