Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7bwz_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 6.A N PRO 3.A O no hydrogen 3.046 N/A LEU 7.A N PRO 3.A O no hydrogen 3.440 N/A GLN 8.A N PRO 4.A O no hydrogen 2.692 N/A GLN 8.A NE2 ASP 5.A O no hydrogen 2.859 N/A GLN 8.A NE2 ILE 6.A O no hydrogen 3.639 N/A GLU 11.A N GLN 8.A O no hydrogen 3.175 N/A PHE 12.A N LEU 7.A O no hydrogen 3.050 N/A GLU 13.A N LEU 50.A O no hydrogen 2.901 N/A ILE 15.A N ALA 48.A O no hydrogen 2.882 N/A TYR 16.A OH HIS 45.A ND1 no hydrogen 2.642 N/A PHE 17.A N PHE 46.A O no hydrogen 3.099 N/A GLN 18.A N SER 279.A O.A no hydrogen 2.962 N/A GLN 18.A N SER 279.A O.B no hydrogen 2.959 N/A GLN 18.A NE2 TYR 16.A OH no hydrogen 2.874 N/A THR 19.A N ARG 44.A O no hydrogen 2.895 N/A ASN 20.A N VAL 281.A O no hydrogen 2.903 N/A THR 22.A N LYS 42.A O no hydrogen 3.047 N/A THR 22.A OG1 ASN 20.A O no hydrogen 2.775 N/A TYR 23.A OH LYS 113.A O no hydrogen 2.645 N/A ILE 24.A N THR 40.A O no hydrogen 2.924 N/A SER 26.A OG ILE 28.A O no hydrogen 2.619 N/A ILE 28.A N SER 26.A OG no hydrogen 3.161 N/A HIS 29.A N VAL 212.A O.A no hydrogen 3.025 N/A HIS 29.A N VAL 212.A O.B no hydrogen 2.999 N/A ASP 39.A N ILE 67.A O no hydrogen 3.163 N/A THR 40.A OG1 GLN 66.A OE1 no hydrogen 2.386 N/A VAL 41.A N LEU 65.A O no hydrogen 2.952 N/A LYS 42.A N THR 22.A O no hydrogen 2.758 N/A ILE 43.A N VAL 63.A O no hydrogen 2.878 N/A ARG 44.A N THR 19.A OG1 no hydrogen 2.850 N/A HIS 45.A N VAL 61.A O no hydrogen 2.761 N/A HIS 45.A ND1 TYR 16.A OH no hydrogen 2.642 N/A HIS 45.A NE2 TYR 110.A OH no hydrogen 2.789 N/A PHE 46.A N PHE 17.A O no hydrogen 2.980 N/A PHE 47.A N LEU 59.A O no hydrogen 2.828 N/A ALA 48.A N ILE 15.A O no hydrogen 2.785 N/A LEU 49.A N LEU 57.A O no hydrogen 3.062 N/A LEU 50.A N GLU 13.A O no hydrogen 2.622 N/A HIS 51.A N LEU 54.A O no hydrogen 2.833 N/A HIS 51.A ND1 GLU 87.A OE1 no hydrogen 2.873 N/A HIS 51.A NE2 GLU 11.A OE2 no hydrogen 2.752 N/A LEU 54.A N HIS 51.A O no hydrogen 3.036 N/A VAL 56.A N LEU 49.A O no hydrogen 2.752 N/A GLY 58.A N ASP 82.A O no hydrogen 2.901 N/A LEU 59.A N PHE 47.A O no hydrogen 2.839 N/A GLU 60.A N LYS 80.A O no hydrogen 2.806 N/A VAL 61.A N HIS 45.A O no hydrogen 2.930 N/A PHE 62.A N TYR 77.A O no hydrogen 2.859 N/A VAL 63.A N ILE 43.A O no hydrogen 2.848 N/A TYR 64.A N TYR 75.A O no hydrogen 2.764 N/A LEU 65.A N VAL 41.A O no hydrogen 2.779 N/A GLN 66.A N GLU 73.A O no hydrogen 2.760 N/A GLN 66.A NE2 SER 26.A OG no hydrogen 3.124 N/A ILE 67.A N ASP 39.A O no hydrogen 2.720 N/A TYR 68.A N PHE 71.A O no hydrogen 2.862 N/A VAL 72.A N THR 125.A O no hydrogen 2.834 N/A GLU 73.A N GLN 66.A O no hydrogen 2.899 N/A LYS 74.A N ASN 127.A O no hydrogen 2.839 N/A LYS 74.A NZ ILE 105.A O no hydrogen 2.788 N/A LYS 74.A NZ TYR 107.A O no hydrogen 3.245 N/A LYS 74.A NZ ASN 108.A OD1.B no hydrogen 2.996 N/A TYR 75.A N TYR 64.A O no hydrogen 2.809 N/A VAL 76.A N ARG 129.A O no hydrogen 2.703 N/A TYR 77.A N PHE 62.A O no hydrogen 2.817 N/A TYR 77.A OH PRO 219.A O no hydrogen 2.683 N/A VAL 78.A N CYS 131.A O no hydrogen 3.054 N/A SER 79.A N GLU 60.A O no hydrogen 2.858 N/A SER 79.A OG GLU 60.A OE1 no hydrogen 2.688 N/A LYS 80.A N GLU 60.A O no hydrogen 3.199 N/A LYS 80.A NZ ASP 220.A OD2 no hydrogen 2.694 N/A CYS 81.A SG GLY 58.A O no hydrogen 4.048 N/A ASP 82.A N GLY 58.A O no hydrogen 3.027 N/A THR 83.A N ASP 82.A OD1 no hydrogen 2.808 N/A VAL 84.A N VAL 56.A O no hydrogen 2.981 N/A SER 89.A OG ILE 91.A O no hydrogen 3.144 N/A LYS 95.A N LYS 92.A O no hydrogen 2.960 N/A VAL 96.A N ILE 93.A O no hydrogen 2.952 N/A ILE 97.A N ILE 93.A O no hydrogen 2.935 N/A GLY 98.A N GLY 94.A O no hydrogen 3.001 N/A VAL 100.A N VAL 96.A O no hydrogen 3.083 N/A LEU 101.A N ILE 97.A O no hydrogen 2.796 N/A GLN 102.A N GLY 98.A O no hydrogen 2.885 N/A TYR 103.A N PRO 99.A O no hydrogen 2.920 N/A TYR 103.A OH ASP 276.A OD2 no hydrogen 2.525 N/A ILE 104.A N VAL 100.A O no hydrogen 2.982 N/A ILE 105.A N LEU 101.A O no hydrogen 2.931 N/A ASN 106.A N GLN 102.A O no hydrogen 2.989 N/A ASN 106.A ND2 GLN 102.A O no hydrogen 2.933 N/A TYR 107.A N ILE 104.A O no hydrogen 3.338 N/A TYR 107.A OH ASP 276.A O no hydrogen 2.810 N/A ASN 108.A ND2.A THR 272.A O no hydrogen 3.176 N/A TYR 110.A OH HIS 45.A NE2 no hydrogen 2.789 N/A LYS 111.A NZ TYR 273.A OH.B no hydrogen 2.643 N/A LYS 115.A NZ ASP 39.A OD1 no hydrogen 2.721 N/A TYR 119.A N GLU 118.A OE1 no hydrogen 3.040 N/A ARG 120.A N ILE 112.A O no hydrogen 2.628 N/A ARG 120.A NH1 TYR 23.A OH no hydrogen 3.025 N/A ARG 120.A NH1 ASP 39.A OD2 no hydrogen 2.813 N/A ARG 120.A NH2 ASP 39.A OD2 no hydrogen 3.348 N/A GLN 126.A N LEU 269.A O no hydrogen 2.862 N/A GLN 126.A NE2 ASN 108.A OD1.A no hydrogen 3.287 N/A GLN 126.A NE2 ASN 108.A OD1.B no hydrogen 3.338 N/A GLN 126.A NE2 TYR 273.A OH.A no hydrogen 2.347 N/A ASN 127.A N VAL 72.A O no hydrogen 2.797 N/A ASN 127.A ND2 GLU 73.A OE2 no hydrogen 2.940 N/A LEU 128.A N LYS 266.A O no hydrogen 2.733 N/A ARG 129.A N LYS 74.A O no hydrogen 2.807 N/A ARG 129.A NE GLU 73.A OE1 no hydrogen 3.049 N/A ARG 129.A NH1 LEU 128.A O no hydrogen 2.982 N/A ARG 129.A NH1 GLU 267.A OE1 no hydrogen 3.320 N/A ARG 129.A NH1 GLU 267.A OE2 no hydrogen 2.786 N/A ARG 129.A NH2 GLU 73.A OE1 no hydrogen 3.218 N/A ARG 129.A NH2 GLU 267.A OE1 no hydrogen 3.004 N/A LEU 130.A N CYS 264.A O no hydrogen 2.784 N/A CYS 131.A N VAL 76.A O no hydrogen 2.838 N/A VAL 132.A N ILE 262.A O no hydrogen 2.994 N/A THR 134.A N SER 260.A O no hydrogen 2.796 N/A ALA 137.A N TYR 140.A OH no hydrogen 2.796 N/A TYR 140.A N ASP 82.A OD2 no hydrogen 3.037 N/A TYR 140.A OH LYS 135.A O no hydrogen 3.016 N/A LEU 141.A N ASP 82.A OD2 no hydrogen 3.128 N/A PHE 142.A N ASP 82.A OD2 no hydrogen 3.188 N/A ASN 144.A N GLU 139.A OE1 no hydrogen 2.739 N/A ASN 144.A ND2 ASP 297.A OD1 no hydrogen 3.050 N/A SER 145.A N PHE 142.A O no hydrogen 3.182 N/A SER 145.A OG PHE 142.A O no hydrogen 2.531 N/A ALA 146.A N GLU 139.A OE2 no hydrogen 3.224 N/A ASN 148.A N SER 145.A O no hydrogen 2.993 N/A ASN 148.A ND2 VAL 84.A O no hydrogen 2.873 N/A ASN 148.A ND2 PHE 298.A O no hydrogen 2.810 N/A TYR 150.A N GLY 85.A O no hydrogen 3.030 N/A LYS 151.A N ASN 148.A O no hydrogen 3.412 N/A LYS 151.A NZ ASP 82.A OD1 no hydrogen 2.799 N/A LYS 151.A NZ ASP 82.A OD2 no hydrogen 3.410 N/A LYS 151.A NZ THR 83.A O no hydrogen 3.082 N/A LYS 151.A NZ LYS 138.A O no hydrogen 2.780 N/A LYS 151.A NZ SER 145.A OG no hydrogen 2.833 N/A GLY 156.A N ASP 257.A OD2 no hydrogen 2.796 N/A SER 158.A N ASN 155.A OD1 no hydrogen 2.842 N/A SER 158.A OG ASN 155.A OD1 no hydrogen 2.756 N/A LEU 159.A N ASN 155.A O no hydrogen 2.891 N/A LEU 160.A N GLY 156.A O no hydrogen 2.977 N/A ARG 161.A N.A GLN 157.A O.A no hydrogen 2.962 N/A ARG 161.A N.A GLN 157.A O.B no hydrogen 3.168 N/A ARG 161.A N.B GLN 157.A O.A no hydrogen 2.950 N/A ARG 161.A N.B GLN 157.A O.B no hydrogen 3.157 N/A ARG 161.A NH1.A GLN 157.A OE1.A no hydrogen 2.672 N/A ARG 161.A NH2.A GLN 157.A OE1.A no hydrogen 2.698 N/A TRP 162.A N SER 158.A O no hydrogen 3.001 N/A TRP 163.A N LEU 159.A O no hydrogen 2.942 N/A ILE 164.A N LEU 160.A O no hydrogen 2.856 N/A SER 165.A N ARG 161.A O.A no hydrogen 3.019 N/A SER 165.A N ARG 161.A O.B no hydrogen 3.043 N/A ILE 166.A N.A TRP 162.A O no hydrogen 3.020 N/A ILE 166.A N.B TRP 162.A O no hydrogen 3.050 N/A ILE 167.A N TRP 163.A O no hydrogen 2.865 N/A ASP 168.A N ILE 164.A O no hydrogen 2.860 N/A SER 169.A N SER 165.A O no hydrogen 3.309 N/A SER 169.A OG ILE 166.A O.A no hydrogen 2.631 N/A SER 169.A OG ILE 166.A O.B no hydrogen 2.515 N/A ILE 170.A N ILE 167.A O no hydrogen 3.098 N/A THR 171.A N ASP 168.A O no hydrogen 3.475 N/A THR 171.A OG1 ILE 167.A O no hydrogen 2.655 N/A THR 171.A OG1 HIS 177.A NE2 no hydrogen 3.022 N/A LYS 172.A NZ SER 169.A O no hydrogen 3.567 N/A TRP 174.A N THR 171.A O no hydrogen 3.143 N/A ASN 175.A N CYS 265.A O no hydrogen 2.724 N/A ASN 176.A N CYS 265.A O no hydrogen 3.280 N/A HIS 177.A NE2 THR 171.A O no hydrogen 2.826 N/A LYS 178.A N GLY 263.A O no hydrogen 2.653 N/A LYS 178.A NZ SER 200.A OG no hydrogen 2.768 N/A LYS 178.A NZ GLU 201.A O no hydrogen 3.107 N/A LEU 179.A N SER 200.A O no hydrogen 2.970 N/A MET 180.A N LEU 261.A O no hydrogen 2.895 N/A ALA 184.A N ILE 181.A O no hydrogen 2.872 N/A TYR 187.A N ASP 185.A OD2 no hydrogen 2.910 N/A ALA 188.A N ASP 185.A OD2 no hydrogen 3.284 N/A THR 189.A N ASP 185.A O no hydrogen 3.124 N/A THR 189.A OG1 ASP 185.A O no hydrogen 3.175 N/A ARG 190.A N LYS 186.A O no hydrogen 2.824 N/A LYS 191.A N TYR 187.A O no hydrogen 3.079 N/A PHE 192.A N THR 189.A O no hydrogen 3.226 N/A ILE 193.A N ARG 190.A O no hydrogen 3.071 N/A TYR 196.A N ILE 193.A O no hydrogen 2.961 N/A TRP 199.A N TYR 196.A O no hydrogen 3.014 N/A TRP 199.A NE1 ASP 168.A OD1 no hydrogen 2.791 N/A SER 200.A N HIS 177.A O no hydrogen 2.911 N/A GLY 202.A N LEU 179.A O no hydrogen 2.855 N/A PHE 205.A N HIS 203.A ND1 no hydrogen 3.056 N/A LYS 207.A NZ HIS 203.A O no hydrogen 2.426 N/A LYS 207.A NZ PHE 205.A O no hydrogen 2.804 N/A ALA 211.A N MET 238.A O no hydrogen 2.822 N/A GLN 213.A N LEU 210.A O no hydrogen 3.047 N/A ALA 214.A N ALA 211.A O no hydrogen 2.937 N/A ILE 215.A N ALA 211.A O no hydrogen 2.900 N/A LEU 217.A N PRO 27.A O no hydrogen 2.859 N/A ARG 224.A N ASP 221.A O no hydrogen 2.884 N/A ARG 224.A NE GLU 252.A OE1 no hydrogen 2.795 N/A ARG 224.A NH1 ASP 220.A OD1 no hydrogen 2.749 N/A ARG 224.A NH2 GLU 252.A OE2 no hydrogen 2.798 N/A GLU 227.A N GLY 223.A O no hydrogen 2.781 N/A LEU 228.A N ARG 224.A O no hydrogen 3.238 N/A VAL 229.A N PHE 225.A O no hydrogen 2.941 N/A ILE 230.A N LEU 226.A O no hydrogen 3.021 N/A VAL 231.A N GLU 227.A O no hydrogen 2.906 N/A GLU 232.A N LEU 228.A O no hydrogen 2.962 N/A CYS 233.A N ILE 230.A O no hydrogen 2.881 N/A CYS 233.A SG ILE 230.A O no hydrogen 3.943 N/A ARG 234.A N VAL 229.A O no hydrogen 2.786 N/A ARG 234.A NE GLU 232.A OE1 no hydrogen 2.817 N/A ARG 234.A NH1 GLU 232.A OE1 no hydrogen 3.180 N/A LYS 237.A N ARG 234.A O no hydrogen 3.111 N/A MET 238.A N ARG 234.A O no hydrogen 3.240 N/A THR 239.A OG1 SER 241.A OG no hydrogen 3.177 N/A VAL 240.A N GLY 209.A O no hydrogen 2.942 N/A SER 241.A OG THR 239.A OG1 no hydrogen 3.177 N/A ARG 242.A N THR 239.A OG1 no hydrogen 3.115 N/A ARG 242.A NE GLN 245.A OE1 no hydrogen 2.877 N/A PHE 243.A N THR 239.A O no hydrogen 2.919 N/A TYR 244.A N VAL 240.A O no hydrogen 3.112 N/A GLN 245.A N SER 241.A O no hydrogen 2.964 N/A GLU 246.A N ARG 242.A O no hydrogen 2.872 N/A LEU 247.A N PHE 243.A O no hydrogen 2.820 N/A TYR 249.A N GLU 246.A O no hydrogen 2.914 N/A ARG 250.A N.A LEU 247.A O no hydrogen 3.159 N/A ARG 250.A N.B LEU 247.A O no hydrogen 3.189 N/A PHE 253.A N ARG 250.A O.A no hydrogen 3.029 N/A PHE 253.A N ARG 250.A O.B no hydrogen 2.879 N/A LEU 254.A N ARG 250.A O.A no hydrogen 2.826 N/A LEU 254.A N ARG 250.A O.B no hydrogen 2.915 N/A LEU 255.A N GLN 251.A O no hydrogen 2.916 N/A GLY 256.A N PHE 253.A O no hydrogen 3.004 N/A SER 260.A N THR 134.A O no hydrogen 2.884 N/A SER 260.A OG CYS 258.A O no hydrogen 2.820 N/A LEU 261.A N MET 180.A O no hydrogen 2.798 N/A ILE 262.A N VAL 132.A O no hydrogen 2.771 N/A GLY 263.A N LYS 178.A O no hydrogen 2.987 N/A CYS 264.A N LEU 130.A O no hydrogen 2.902 N/A CYS 265.A N ASN 176.A O no hydrogen 3.120 N/A LYS 266.A N LEU 128.A O no hydrogen 2.910 N/A LYS 266.A NZ GLY 173.A O no hydrogen 3.491 N/A GLU 267.A N ASN 175.A OD1 no hydrogen 2.857 N/A ASN 268.A N ASN 127.A OD1 no hydrogen 2.693 N/A LEU 269.A N GLN 126.A O no hydrogen 2.976 N/A VAL 271.A N LYS 124.A O no hydrogen 2.945 N/A TYR 273.A OH.A PRO 123.A O no hydrogen 2.538 N/A HIS 274.A N ASN 108.A O.A no hydrogen 3.355 N/A HIS 274.A N ASN 108.A O.B no hydrogen 3.108 N/A THR 280.A OG1 ASN 20.A OD1 no hydrogen 3.286 N/A VAL 281.A N GLN 18.A O no hydrogen 2.839 N/A THR 282.A N GLU 285.A OE1 no hydrogen 2.910 N/A GLU 285.A N THR 282.A OG1 no hydrogen 3.050 N/A TYR 286.A N THR 282.A O no hydrogen 2.930 N/A TYR 286.A OH GLU 60.A OE2 no hydrogen 2.666 N/A LYS 287.A N ILE 283.A O.A no hydrogen 2.837 N/A LYS 287.A N ILE 283.A O.B no hydrogen 2.831 N/A GLU 288.A N SER 284.A O no hydrogen 2.874 N/A PHE 289.A N GLU 285.A O no hydrogen 3.044 N/A MET 290.A N TYR 286.A O no hydrogen 2.993 N/A ASN 291.A N LYS 287.A O no hydrogen 2.777 N/A LEU 292.A N GLU 288.A O no hydrogen 2.952 N/A LEU 293.A N PHE 289.A O no hydrogen 3.004 N/A LYS 294.A N MET 290.A O no hydrogen 3.148 N/A LYS 294.A NZ ASN 291.A OD1 no hydrogen 3.146 N/A LEU 295.A N LEU 292.A O no hydrogen 3.161 N/A VAL 296.A N LEU 293.A O no hydrogen 3.125 N/A ASP 297.A N GLU 303.A OE1 no hydrogen 2.914 N/A PHE 298.A N PRO 143.A O no hydrogen 3.005 N/A SER 299.A N ASP 297.A OD1 no hydrogen 2.981 N/A SER 299.A OG ASP 297.A OD1 no hydrogen 2.586 N/A SER 299.A OG ASP 297.A OD2 no hydrogen 3.419 N/A ASP 300.A N ASP 297.A O no hydrogen 2.945 N/A VAL 302.A N ASP 300.A OD1 no hydrogen 2.884 N/A VAL 304.A N ASP 300.A O no hydrogen 3.066 N/A SER 305.A N ARG 301.A O no hydrogen 2.865 N/A SER 305.A OG ARG 301.A O no hydrogen 2.765 N/A ASN 306.A N VAL 302.A O no hydrogen 2.911 N/A PHE 307.A N GLU 303.A O no hydrogen 2.867 N/A VAL 308.A N VAL 304.A O no hydrogen 2.995 N/A SER 309.A N SER 305.A O no hydrogen 2.946 N/A SER 309.A OG ASN 306.A O no hydrogen 3.307 N/A ASN 310.A N ASN 306.A O no hydrogen 2.956 N/A TYR 311.A N PHE 307.A O no hydrogen 2.978 N/A ARG 312.A N VAL 308.A O no hydrogen 3.013 N/A ARG 312.A NH1 ASP 53.A OD1 no hydrogen 2.548 N/A ARG 312.A NH2 GLU 13.A OE1 no hydrogen 2.677 N/A ARG 312.A NH2 GLN 52.A O no hydrogen 2.686 N/A LYS 313.A N SER 309.A O no hydrogen 3.154 N/A SER 314.A N TYR 311.A O no hydrogen 3.065 N/A SER 314.A OG ASN 310.A O no hydrogen 3.421 N/A SER 314.A OG TYR 311.A O no hydrogen 3.547 N/A