Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7dxq_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 3.A NZ SER 15.A O no hydrogen 3.054 N/A LYS 3.A NZ HIS 16.A O no hydrogen 3.243 N/A LYS 3.A NZ SER 199.A O no hydrogen 3.160 N/A MET 4.A N LEU 19.A O no hydrogen 3.080 N/A THR 6.A N ASP 12.A OD1 no hydrogen 2.762 N/A THR 6.A OG1 ASP 12.A OD1 no hydrogen 2.899 N/A MET 7.A N ASP 12.A OD2 no hydrogen 3.009 N/A ILE 8.A N THR 6.A OG1 no hydrogen 3.274 N/A PHE 11.A N ILE 8.A O no hydrogen 2.781 N/A ILE 14.A N GLY 10.A O no hydrogen 3.331 N/A SER 15.A N PHE 11.A O no hydrogen 2.875 N/A SER 15.A OG PHE 11.A O no hydrogen 2.867 N/A SER 15.A OG ASP 12.A O no hydrogen 3.234 N/A SER 15.A OG GLY 18.A O no hydrogen 3.071 N/A HIS 16.A N ASP 13.A O no hydrogen 3.251 N/A GLY 17.A N ASP 12.A O no hydrogen 2.763 N/A LEU 19.A N MET 4.A O no hydrogen 3.174 N/A ILE 21.A N ALA 2.A O no hydrogen 2.905 N/A GLY 22.A N THR 147.A OG1 no hydrogen 2.980 N/A THR 25.A N THR 148.A O no hydrogen 2.954 N/A LEU 26.A N ASN 173.A O no hydrogen 2.733 N/A VAL 27.A N MET 150.A O no hydrogen 2.958 N/A SER 28.A N VAL 175.A O no hydrogen 3.365 N/A SER 28.A OG ILE 161.A O no hydrogen 2.608 N/A THR 30.A OG1 GLU 157.A OE1 no hydrogen 3.357 N/A THR 30.A OG1 GLU 157.A OE2 no hydrogen 3.146 N/A THR 33.A OG1 THR 30.A O no hydrogen 2.720 N/A LYS 35.A NZ GLY 29.A O no hydrogen 2.750 N/A LYS 35.A NZ THR 30.A O no hydrogen 3.026 N/A THR 36.A OG1 ASP 119.A OD1 no hydrogen 3.031 N/A PHE 38.A N GLY 34.A O no hydrogen 2.893 N/A SER 39.A OG THR 36.A O no hydrogen 2.547 N/A ILE 40.A N THR 36.A O no hydrogen 3.239 N/A GLN 41.A N LEU 37.A O no hydrogen 3.058 N/A PHE 42.A N PHE 38.A O no hydrogen 3.103 N/A LEU 43.A N SER 39.A O no hydrogen 3.392 N/A TYR 44.A N ILE 40.A O no hydrogen 2.961 N/A ASN 45.A N GLN 41.A O no hydrogen 3.162 N/A ASN 45.A ND2 THR 6.A O no hydrogen 3.387 N/A ASN 45.A ND2 GLN 41.A O no hydrogen 3.081 N/A GLY 46.A N PHE 42.A O no hydrogen 3.368 N/A ILE 47.A N LEU 43.A O no hydrogen 3.065 N/A ILE 47.A N TYR 44.A O no hydrogen 2.945 N/A ILE 48.A N TYR 44.A O no hydrogen 2.764 N/A ASP 51.A N ILE 47.A O no hydrogen 2.556 N/A GLU 52.A N GLY 46.A O no hydrogen 3.263 N/A GLY 54.A N LYS 85.A O no hydrogen 3.342 N/A VAL 55.A N ARG 115.A O no hydrogen 2.832 N/A PHE 56.A N PHE 87.A O no hydrogen 3.062 N/A VAL 57.A N SER 117.A O no hydrogen 3.008 N/A THR 58.A N LEU 89.A O no hydrogen 3.398 N/A THR 58.A OG1 GLU 61.A O no hydrogen 3.119 N/A THR 62.A OG1 ASP 65.A OD2 no hydrogen 2.726 N/A ASP 65.A N THR 62.A OG1 no hydrogen 3.293 N/A ILE 66.A N THR 62.A O no hydrogen 2.953 N/A ILE 67.A N PRO 63.A O no hydrogen 3.010 N/A LYS 68.A N GLN 64.A O no hydrogen 2.882 N/A ASN 69.A N ASP 65.A O no hydrogen 2.778 N/A ALA 70.A N ILE 66.A O no hydrogen 2.509 N/A ARG 71.A N LYS 68.A O no hydrogen 3.308 N/A GLY 74.A N ARG 71.A O no hydrogen 2.714 N/A LEU 77.A N TRP 75.A O no hydrogen 2.785 N/A LEU 80.A N ASP 76.A O no hydrogen 3.319 N/A VAL 81.A N LEU 77.A O no hydrogen 3.162 N/A ASP 82.A N ALA 78.A O no hydrogen 3.025 N/A GLU 83.A N LYS 79.A O no hydrogen 2.378 N/A LEU 86.A N LEU 80.A O no hydrogen 3.034 N/A PHE 87.A N GLY 54.A O no hydrogen 3.300 N/A LEU 89.A N PHE 56.A O no hydrogen 2.753 N/A ALA 91.A N ASP 90.A OD1 no hydrogen 2.597 N/A SER 92.A N ASP 90.A OD1 no hydrogen 3.006 N/A SER 92.A OG ASP 90.A OD1 no hydrogen 2.719 N/A LEU 100.A N LEU 97.A O no hydrogen 3.206 N/A ILE 101.A N LEU 97.A O no hydrogen 3.407 N/A GLU 102.A N SER 98.A O no hydrogen 2.868 N/A ARG 103.A N ALA 99.A O no hydrogen 2.798 N/A ILE 104.A N ILE 101.A O no hydrogen 3.158 N/A ASN 105.A N ILE 101.A O no hydrogen 2.877 N/A TYR 106.A N GLU 102.A O no hydrogen 3.202 N/A ILE 108.A N ILE 104.A O no hydrogen 2.735 N/A GLN 109.A N ASN 105.A O no hydrogen 2.988 N/A LYS 110.A N TYR 106.A O no hydrogen 2.798 N/A TYR 111.A N ALA 107.A O no hydrogen 3.121 N/A ALA 113.A N ILE 108.A O no hydrogen 2.972 N/A ARG 114.A N PRO 53.A O no hydrogen 3.346 N/A ARG 115.A NH1 PHE 42.A O no hydrogen 2.557 N/A ARG 115.A NH2 ARG 5.A O no hydrogen 2.523 N/A VAL 116.A N THR 147.A O no hydrogen 3.210 N/A SER 117.A N VAL 55.A O no hydrogen 3.072 N/A SER 117.A OG SER 39.A O no hydrogen 3.168 N/A SER 120.A OG SER 123.A OG no hydrogen 2.884 N/A SER 120.A OG GLU 153.A OE1 no hydrogen 3.417 N/A VAL 121.A N THR 151.A O no hydrogen 3.099 N/A SER 123.A N SER 120.A OG no hydrogen 3.411 N/A SER 123.A OG SER 120.A O no hydrogen 2.259 N/A SER 123.A OG SER 120.A OG no hydrogen 2.884 N/A GLN 126.A N VAL 124.A O no hydrogen 2.324 N/A ARG 131.A N SER 127.A O no hydrogen 2.999 N/A GLU 133.A N VAL 129.A O no hydrogen 3.486 N/A LEU 134.A N VAL 130.A O no hydrogen 2.846 N/A PHE 135.A N ARG 131.A O no hydrogen 2.880 N/A ARG 136.A N ARG 132.A O no hydrogen 2.911 N/A LEU 137.A N GLU 133.A O no hydrogen 3.370 N/A VAL 138.A N LEU 134.A O no hydrogen 3.296 N/A ALA 139.A N PHE 135.A O no hydrogen 2.898 N/A ARG 140.A N ARG 136.A O no hydrogen 3.061 N/A LEU 141.A N LEU 137.A O no hydrogen 3.251 N/A LYS 142.A N VAL 138.A O no hydrogen 3.232 N/A LYS 142.A N ALA 139.A O no hydrogen 2.878 N/A GLN 143.A NE2 ARG 140.A O no hydrogen 3.106 N/A GLY 145.A N LYS 142.A O no hydrogen 3.305 N/A THR 147.A N ARG 114.A O no hydrogen 3.310 N/A MET 150.A N THR 25.A O no hydrogen 3.134 N/A THR 151.A N ILE 118.A O no hydrogen 2.952 N/A THR 151.A OG1 LYS 35.A O no hydrogen 3.506 N/A THR 152.A N VAL 27.A O no hydrogen 3.104 N/A ARG 154.A N GLY 29.A O no hydrogen 2.879 N/A ARG 154.A NE PRO 160.A O no hydrogen 3.206 N/A ARG 154.A NH1 GLU 157.A O no hydrogen 3.192 N/A ARG 154.A NH2 GLU 157.A O no hydrogen 3.019 N/A ARG 154.A NH2 PRO 160.A O no hydrogen 3.331 N/A ARG 163.A N GLU 167.A OE1 no hydrogen 3.040 N/A TYR 164.A N GLU 167.A OE1 no hydrogen 2.922 N/A VAL 166.A N GLU 167.A OE2 no hydrogen 2.613 N/A GLU 167.A N GLU 167.A OE2 no hydrogen 2.342 N/A VAL 170.A N VAL 166.A O no hydrogen 2.980 N/A SER 171.A N GLU 167.A O no hydrogen 3.239 N/A ASN 173.A ND2 THR 25.A OG1 no hydrogen 2.916 N/A VAL 174.A N LYS 194.A O no hydrogen 3.004 N/A VAL 175.A N LEU 26.A O no hydrogen 2.829 N/A ILE 176.A N GLU 191.A O no hydrogen 2.666 N/A LEU 177.A N SER 28.A O no hydrogen 3.181 N/A ARG 178.A N THR 189.A O no hydrogen 2.982 N/A ARG 178.A NE GLU 157.A O no hydrogen 3.224 N/A ARG 178.A NH2 GLU 191.A OE2 no hydrogen 3.303 N/A ASN 179.A N GLU 157.A OE2 no hydrogen 2.893 N/A VAL 180.A N ARG 187.A O no hydrogen 2.971 N/A GLU 182.A N ARG 185.A O no hydrogen 2.590 N/A ARG 186.A NH1 ASN 179.A O no hydrogen 2.366 N/A ARG 187.A N VAL 180.A O no hydrogen 2.973 N/A ARG 188.A NH1 GLY 32.A O no hydrogen 3.195 N/A ARG 188.A NH2 GLY 32.A O no hydrogen 3.550 N/A THR 189.A N ARG 178.A O no hydrogen 3.293 N/A THR 189.A OG1 GLU 204.A OE1 no hydrogen 2.995 N/A LEU 190.A N TYR 205.A O no hydrogen 2.734 N/A GLU 191.A N ILE 176.A O no hydrogen 2.958 N/A LYS 194.A N VAL 174.A O no hydrogen 3.434 N/A LYS 194.A NZ GLU 168.A O no hydrogen 3.149 N/A LYS 194.A NZ SER 171.A O no hydrogen 2.847 N/A ARG 196.A N ASP 172.A O no hydrogen 3.433 N/A THR 198.A N LEU 195.A O no hydrogen 3.177 N/A THR 198.A OG1 LEU 195.A O no hydrogen 3.495 N/A MET 201.A N ILE 14.A O no hydrogen 2.741 N/A TYR 205.A N LEU 190.A O no hydrogen 2.667 N/A TYR 205.A OH LYS 202.A O no hydrogen 3.331 N/A PHE 207.A N ARG 188.A O no hydrogen 3.246 N/A THR 210.A N GLY 213.A O no hydrogen 2.835 N/A THR 210.A OG1 GLY 213.A O no hydrogen 3.336 N/A ILE 214.A N GLN 41.A OE1 no hydrogen 2.621 N/A ASN 215.A N THR 208.A O no hydrogen 3.049 N/A ILE 216.A N GLU 9.A O no hydrogen 2.855 N/A PHE 217.A N PRO 206.A O no hydrogen 2.911 N/A ARG 228.A NH2 SER 425.A OG no hydrogen 2.322 N/A VAL 229.A N PHE 244.A O no hydrogen 2.474 N/A ASP 237.A N VAL 233.A O no hydrogen 3.021 N/A GLU 238.A N VAL 234.A O no hydrogen 3.280 N/A MET 239.A N ARG 235.A O no hydrogen 2.885 N/A CYS 240.A N LEU 236.A O no hydrogen 3.156 N/A CYS 240.A SG LEU 236.A O no hydrogen 3.290 N/A GLY 241.A N GLU 238.A O no hydrogen 3.227 N/A GLY 242.A N ASP 237.A O no hydrogen 3.074 N/A PHE 244.A N VAL 229.A O no hydrogen 2.874 N/A LYS 246.A N VAL 227.A O no hydrogen 2.781 N/A SER 248.A OG PHE 245.A O no hydrogen 2.518 N/A ILE 249.A N ASP 399.A OD2 no hydrogen 2.980 N/A ILE 250.A N GLY 376.A O no hydrogen 2.771 N/A ALA 252.A N PHE 378.A O no hydrogen 3.028 N/A THR 253.A N ILE 402.A O no hydrogen 2.782 N/A GLY 254.A N ASN 380.A O no hydrogen 3.436 N/A THR 258.A OG1 ALA 255.A O no hydrogen 3.201 N/A LYS 260.A NZ ALA 255.A O no hydrogen 2.943 N/A LYS 260.A NZ THR 381.A OG1 no hydrogen 2.549 N/A THR 261.A OG1 ASP 344.A OD2 no hydrogen 3.274 N/A LEU 263.A N GLY 259.A O no hydrogen 3.181 N/A VAL 264.A N LYS 260.A O no hydrogen 3.113 N/A SER 265.A N LEU 262.A O no hydrogen 2.598 N/A SER 265.A OG THR 261.A O no hydrogen 2.830 N/A SER 265.A OG LEU 262.A O no hydrogen 2.853 N/A ARG 266.A N LEU 262.A O no hydrogen 3.269 N/A ARG 266.A NE GLY 232.A O no hydrogen 2.970 N/A PHE 267.A N LEU 263.A O no hydrogen 2.844 N/A VAL 268.A N VAL 264.A O no hydrogen 3.008 N/A GLU 269.A N SER 265.A O no hydrogen 3.053 N/A ASN 270.A N ARG 266.A O no hydrogen 2.877 N/A CYS 272.A SG VAL 268.A O no hydrogen 3.532 N/A CYS 272.A SG LEU 309.A O no hydrogen 3.391 N/A ALA 273.A N GLU 269.A O no hydrogen 3.162 N/A LYS 275.A N CYS 272.A O no hydrogen 3.337 N/A GLU 276.A N ALA 271.A O no hydrogen 2.760 N/A ARG 277.A NE PHE 336.A O no hydrogen 2.596 N/A ARG 277.A NE LYS 337.A O no hydrogen 3.211 N/A ARG 277.A NH2 LYS 337.A O no hydrogen 2.938 N/A LEU 280.A N LYS 311.A O no hydrogen 2.898 N/A PHE 281.A N ALA 342.A O no hydrogen 3.042 N/A TYR 283.A N ASP 344.A O no hydrogen 2.810 N/A GLN 289.A N SER 286.A OG no hydrogen 3.384 N/A LEU 290.A N SER 286.A O no hydrogen 3.031 N/A LEU 291.A N ARG 287.A O no hydrogen 3.009 N/A ARG 292.A N ALA 288.A O no hydrogen 2.945 N/A ASN 293.A N GLN 289.A O no hydrogen 2.828 N/A ASN 293.A ND2 GLN 289.A O no hydrogen 2.556 N/A ALA 294.A N LEU 290.A O no hydrogen 2.326 N/A TYR 295.A N LEU 291.A O no hydrogen 2.769 N/A SER 296.A N ARG 292.A O no hydrogen 2.914 N/A SER 296.A OG ARG 292.A O no hydrogen 3.323 N/A GLY 298.A N TYR 295.A O no hydrogen 2.554 N/A GLU 303.A N ASP 300.A O no hydrogen 3.110 N/A MET 304.A N ASP 300.A O no hydrogen 3.217 N/A GLU 305.A N PHE 301.A O no hydrogen 3.133 N/A GLN 307.A N GLU 303.A O no hydrogen 3.172 N/A ASN 308.A N GLU 305.A O no hydrogen 3.184 N/A LEU 309.A N MET 304.A O no hydrogen 3.397 N/A LYS 311.A N ALA 278.A O no hydrogen 2.956 N/A VAL 313.A N LEU 280.A O no hydrogen 2.902 N/A CYS 314.A SG GLU 285.A O no hydrogen 4.019 N/A ALA 315.A N ALA 282.A O no hydrogen 3.105 N/A SER 319.A N TYR 316.A O no hydrogen 3.148 N/A SER 319.A OG TYR 316.A O no hydrogen 2.545 N/A HIS 325.A N GLY 321.A O no hydrogen 3.027 N/A HIS 325.A NE2 PRO 317.A O no hydrogen 2.960 N/A LEU 326.A N LEU 322.A O no hydrogen 2.855 N/A GLN 327.A N GLU 323.A O no hydrogen 3.048 N/A ILE 328.A N ASP 324.A O no hydrogen 3.063 N/A ILE 329.A N HIS 325.A O no hydrogen 3.065 N/A LYS 330.A N LEU 326.A O no hydrogen 2.966 N/A SER 331.A N GLN 327.A O no hydrogen 2.828 N/A SER 331.A OG GLN 327.A O no hydrogen 2.713 N/A SER 331.A OG ILE 328.A O no hydrogen 2.993 N/A GLU 332.A N ILE 328.A O no hydrogen 2.671 N/A ILE 333.A N LYS 330.A O no hydrogen 2.662 N/A ASN 334.A N LYS 330.A O no hydrogen 3.180 N/A ASN 334.A ND2 LYS 330.A O no hydrogen 2.442 N/A ASN 334.A ND2 TYR 368.A OH no hydrogen 3.563 N/A LYS 337.A N ILE 333.A O no hydrogen 3.245 N/A ALA 339.A N ARG 277.A O no hydrogen 2.879 N/A ARG 340.A NE PHE 267.A O no hydrogen 3.347 N/A ARG 340.A NH2 SER 230.A O no hydrogen 2.527 N/A ARG 340.A NH2 PHE 267.A O no hydrogen 3.400 N/A ILE 341.A N THR 375.A O no hydrogen 2.523 N/A ALA 342.A N ILE 279.A O no hydrogen 3.071 N/A ILE 343.A N LEU 377.A O no hydrogen 2.965 N/A ASP 344.A N PHE 281.A O no hydrogen 2.988 N/A SER 345.A OG GLU 284.A OE2 no hydrogen 2.501 N/A SER 345.A OG SER 347.A OG no hydrogen 3.098 N/A LEU 346.A N THR 379.A O no hydrogen 2.654 N/A SER 347.A OG SER 345.A OG no hydrogen 3.098 N/A ALA 350.A N LEU 346.A O no hydrogen 2.984 N/A ARG 351.A NH2 ASP 383.A OD1 no hydrogen 3.481 N/A VAL 353.A N ALA 350.A O no hydrogen 3.374 N/A ASN 355.A ND2 SER 394.A O no hydrogen 3.051 N/A ALA 357.A N SER 354.A OG no hydrogen 3.193 N/A PHE 358.A N SER 354.A O no hydrogen 2.987 N/A ARG 359.A N ASN 355.A O no hydrogen 2.910 N/A ARG 359.A NH1 HIS 395.A O no hydrogen 2.601 N/A ARG 359.A NH2 ASN 355.A OD1 no hydrogen 2.849 N/A GLN 360.A N ASN 356.A O no hydrogen 3.063 N/A PHE 361.A N ALA 357.A O no hydrogen 3.149 N/A VAL 362.A N PHE 358.A O no hydrogen 2.825 N/A ILE 363.A N ARG 359.A O no hydrogen 2.946 N/A GLY 364.A N GLN 360.A O no hydrogen 3.407 N/A VAL 365.A N PHE 361.A O no hydrogen 3.005 N/A THR 366.A N VAL 362.A O no hydrogen 3.009 N/A THR 366.A OG1 VAL 362.A O no hydrogen 2.392 N/A GLY 367.A N ILE 363.A O no hydrogen 2.453 N/A TYR 368.A N VAL 365.A O no hydrogen 2.963 N/A TYR 368.A OH ASN 334.A OD1 no hydrogen 3.246 N/A ALA 369.A N VAL 365.A O no hydrogen 3.228 N/A LYS 370.A N THR 366.A O no hydrogen 3.262 N/A LYS 370.A NZ ASP 399.A OD1 no hydrogen 3.510 N/A LYS 370.A NZ ASP 399.A OD2 no hydrogen 2.528 N/A GLU 373.A N LYS 370.A O no hydrogen 2.796 N/A ILE 374.A N ALA 369.A O no hydrogen 2.532 N/A THR 375.A N ALA 339.A O no hydrogen 3.276 N/A THR 375.A OG1 LYS 246.A O no hydrogen 2.946 N/A GLY 376.A N SER 248.A O no hydrogen 3.225 N/A LEU 377.A N ILE 341.A O no hydrogen 3.007 N/A PHE 378.A N ILE 250.A O no hydrogen 2.882 N/A THR 379.A N ILE 343.A O no hydrogen 2.972 N/A THR 379.A OG1 ILE 343.A O no hydrogen 2.975 N/A THR 379.A OG1 ASP 344.A OD1 no hydrogen 2.682 N/A ASN 380.A N ALA 252.A O no hydrogen 3.212 N/A THR 381.A N SER 347.A OG no hydrogen 3.132 N/A SER 382.A N GLY 254.A O no hydrogen 2.917 N/A SER 382.A OG GLN 384.A O no hydrogen 3.559 N/A ILE 396.A N THR 392.A OG1 no hydrogen 3.023 N/A ASP 399.A N ILE 249.A O no hydrogen 2.863 N/A THR 400.A N ILE 249.A O no hydrogen 3.068 N/A ILE 401.A N LYS 421.A O no hydrogen 3.396 N/A ILE 402.A N LEU 251.A O no hydrogen 2.711 N/A LEU 403.A N ASN 418.A O no hydrogen 2.817 N/A LEU 404.A N THR 253.A O no hydrogen 2.792 N/A GLN 405.A N ALA 416.A O no hydrogen 3.292 N/A TYR 406.A OH THR 256.A O no hydrogen 2.664 N/A VAL 407.A N SER 414.A O no hydrogen 2.553 N/A GLU 408.A N GLY 456.A O no hydrogen 2.941 N/A ILE 409.A N GLU 412.A O no hydrogen 3.104 N/A SER 414.A N VAL 407.A O no hydrogen 2.920 N/A ALA 416.A N GLN 405.A O no hydrogen 2.930 N/A LYS 421.A NZ THR 398.A O no hydrogen 3.311 N/A ARG 423.A N ASP 399.A O no hydrogen 3.017 N/A SER 425.A N MET 422.A O no hydrogen 3.333 N/A SER 425.A OG CYS 240.A O no hydrogen 3.183 N/A SER 425.A OG TRP 426.A O no hydrogen 2.974 N/A ASP 428.A N MET 239.A O no hydrogen 2.584 N/A ARG 432.A N ILE 417.A O no hydrogen 2.949 N/A GLU 433.A N ASP 445.A O no hydrogen 3.367 N/A PHE 434.A N ARG 415.A O no hydrogen 3.488 N/A MET 435.A N ASP 442.A O no hydrogen 3.362 N/A SER 437.A N GLY 440.A O no hydrogen 3.225 N/A ASP 442.A N MET 435.A O no hydrogen 3.122 N/A LYS 444.A N GLU 433.A O no hydrogen 2.659 N/A SER 446.A N ASP 445.A OD1 no hydrogen 2.900 N/A SER 455.A OG ARG 452.A O no hydrogen 2.570 N/A GLY 456.A N ILE 453.A O no hydrogen 3.034 N/A THR 459.A N GLU 451.A O no hydrogen 3.127 N/A ILE 461.A N ASN 449.A O no hydrogen 3.002 N/A