Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7e35_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 5.A N VAL 21.A O no hydrogen 2.971 N/A VAL 7.A N GLN 19.A O no hydrogen 3.006 N/A PHE 8.A N LYS 53.A O no hydrogen 3.137 N/A THR 9.A N HIS 17.A O no hydrogen 2.696 N/A THR 9.A OG1 GLN 19.A OE1 no hydrogen 3.268 N/A THR 10.A N PHE 55.A O no hydrogen 2.934 N/A THR 10.A OG1 ASN 15.A O no hydrogen 2.482 N/A ASP 12.A N THR 10.A OG1 no hydrogen 3.177 N/A ASN 13.A N THR 10.A OG1 no hydrogen 3.007 N/A ILE 14.A N ASP 12.A OD1 no hydrogen 2.706 N/A ASN 15.A N ASP 12.A OD1 no hydrogen 2.820 N/A HIS 17.A N THR 9.A O no hydrogen 2.781 N/A HIS 17.A NE2 GLU 67.A OE1 no hydrogen 2.973 N/A GLN 19.A N VAL 7.A O no hydrogen 2.933 N/A VAL 21.A N ILE 5.A O no hydrogen 2.812 N/A MET 23.A N ARG 3.A O no hydrogen 2.679 N/A MET 25.A N ASP 22.A O no hydrogen 2.929 N/A THR 26.A OG1 THR 42.A O no hydrogen 2.907 N/A THR 26.A OG1 ILE 44.A O no hydrogen 2.842 N/A TYR 27.A N ILE 44.A O no hydrogen 2.984 N/A TYR 27.A OH HIS 50.A ND1 no hydrogen 2.366 N/A GLY 28.A N THR 42.A O no hydrogen 2.562 N/A GLN 29.A N THR 26.A O no hydrogen 3.164 N/A GLN 30.A N TYR 27.A O no hydrogen 2.928 N/A GLN 30.A NE2 ASP 22.A O no hydrogen 3.024 N/A GLN 30.A NE2 MET 25.A O no hydrogen 2.743 N/A PHE 31.A N TYR 27.A O no hydrogen 2.882 N/A PHE 31.A N GLY 28.A O no hydrogen 3.234 N/A GLY 32.A N GLY 28.A O no hydrogen 2.507 N/A THR 34.A N THR 42.A OG1 no hydrogen 2.832 N/A THR 34.A OG1 GLY 32.A O no hydrogen 2.907 N/A TYR 35.A N TYR 56.A O no hydrogen 3.384 N/A LEU 36.A N ALA 39.A O no hydrogen 2.955 N/A ALA 39.A N LEU 36.A O no hydrogen 2.765 N/A VAL 41.A N THR 34.A O no hydrogen 2.563 N/A THR 42.A OG1 THR 34.A O no hydrogen 3.479 N/A ILE 44.A N VAL 41.A O no hydrogen 3.362 N/A HIS 47.A N HIS 50.A ND1 no hydrogen 3.442 N/A HIS 50.A N HIS 47.A O no hydrogen 2.945 N/A HIS 50.A ND1 TYR 27.A OH no hydrogen 2.366 N/A GLU 51.A N ASN 48.A O no hydrogen 3.393 N/A GLY 52.A N LYS 6.A O no hydrogen 3.030 N/A LYS 53.A N HIS 50.A O no hydrogen 3.000 N/A PHE 55.A N PHE 8.A O no hydrogen 2.760 N/A TYR 56.A N TYR 35.A O no hydrogen 3.276 N/A VAL 57.A N THR 10.A O no hydrogen 2.915 N/A ARG 65.A N ASP 61.A O no hydrogen 3.000 N/A VAL 66.A N ASP 62.A O no hydrogen 3.005 N/A GLU 67.A N THR 63.A O no hydrogen 3.005 N/A ALA 68.A N LEU 64.A O no hydrogen 2.827 N/A PHE 69.A N ARG 65.A O no hydrogen 2.927 N/A GLU 70.A N VAL 66.A O no hydrogen 2.898 N/A TYR 71.A N GLU 67.A O no hydrogen 2.964 N/A TYR 71.A OH ASP 134.A OD1 no hydrogen 3.284 N/A TYR 72.A N ALA 68.A O no hydrogen 2.887 N/A TYR 72.A OH VAL 11.A O no hydrogen 2.670 N/A HIS 73.A N PHE 69.A O no hydrogen 2.906 N/A ASP 76.A N THR 74.A OG1 no hydrogen 3.282 N/A SER 78.A N ASP 76.A OD1 no hydrogen 2.783 N/A PHE 79.A N ASP 76.A O no hydrogen 2.976 N/A ARG 82.A N SER 78.A O no hydrogen 2.957 N/A ARG 82.A NH1 ASP 76.A OD2 no hydrogen 3.091 N/A ARG 82.A NH2 ALA 153.A O no hydrogen 2.575 N/A TYR 83.A N PHE 79.A O no hydrogen 2.790 N/A MET 84.A N LEU 80.A O no hydrogen 2.884 N/A SER 85.A N GLY 81.A O no hydrogen 2.921 N/A SER 85.A OG GLY 81.A O no hydrogen 3.024 N/A SER 85.A OG ARG 82.A O no hydrogen 2.689 N/A ALA 86.A N ARG 82.A O no hydrogen 3.009 N/A LEU 87.A N TYR 83.A O no hydrogen 2.868 N/A ASN 88.A N MET 84.A O no hydrogen 2.988 N/A HIS 89.A N ALA 86.A O no hydrogen 2.745 N/A THR 90.A N ALA 86.A O no hydrogen 2.920 N/A THR 90.A OG1 ALA 145.A O no hydrogen 2.880 N/A LYS 91.A N LEU 87.A O no hydrogen 2.945 N/A LYS 91.A NZ ASP 37.A O no hydrogen 2.612 N/A LYS 92.A N HIS 89.A O no hydrogen 2.618 N/A TRP 93.A N THR 90.A O no hydrogen 3.273 N/A TRP 93.A NE1 ASP 108.A OD2 no hydrogen 3.061 N/A TYR 95.A OH THR 90.A O no hydrogen 2.726 N/A GLN 97.A NE2 THR 102.A OG1 no hydrogen 2.603 N/A VAL 98.A N LEU 101.A O no hydrogen 2.877 N/A LEU 101.A N VAL 98.A O no hydrogen 3.208 N/A THR 102.A N GLN 121.A OE1 no hydrogen 2.756 N/A THR 102.A OG1 GLN 121.A OE1 no hydrogen 3.557 N/A THR 102.A OG1 ALA 139.A O no hydrogen 2.644 N/A THR 102.A OG1 ARG 140.A O no hydrogen 3.303 N/A SER 103.A N PRO 96.A O no hydrogen 3.026 N/A SER 103.A OG GLY 287.A O no hydrogen 2.908 N/A LYS 105.A N LYS 94.A O no hydrogen 2.808 N/A TRP 106.A NE1 SER 111.A OG no hydrogen 3.243 N/A ALA 107.A N ASN 110.A OD1 no hydrogen 3.180 N/A ASN 109.A ND2 GLY 160.A O no hydrogen 3.265 N/A ASN 110.A N ALA 107.A O no hydrogen 3.028 N/A ASN 110.A ND2 LYS 105.A O no hydrogen 3.513 N/A SER 111.A OG HIS 272.A ND1 no hydrogen 2.707 N/A ALA 114.A N ASN 110.A O no hydrogen 3.076 N/A THR 115.A N SER 111.A O no hydrogen 3.063 N/A ALA 116.A N TYR 112.A O no hydrogen 2.810 N/A LEU 117.A N LEU 113.A O no hydrogen 2.734 N/A LEU 118.A N ALA 114.A O no hydrogen 2.955 N/A THR 119.A N THR 115.A O no hydrogen 2.917 N/A THR 119.A OG1 THR 115.A O no hydrogen 2.932 N/A LEU 120.A N ALA 116.A O no hydrogen 2.772 N/A GLN 121.A N LEU 117.A O no hydrogen 3.149 N/A GLN 121.A N LEU 118.A O no hydrogen 2.953 N/A GLN 121.A NE2 THR 102.A O no hydrogen 2.646 N/A GLN 121.A NE2 LEU 117.A O no hydrogen 2.936 N/A GLN 122.A N THR 119.A O no hydrogen 2.844 N/A GLN 122.A NE2 LEU 118.A O no hydrogen 3.317 N/A GLN 122.A NE2 HIS 275.A NE2 no hydrogen 2.741 N/A PHE 127.A N GLN 133.A OE1 no hydrogen 3.065 N/A ASN 128.A N HIS 175.A O no hydrogen 3.081 N/A ALA 131.A N TYR 71.A O no hydrogen 2.974 N/A GLN 133.A N PRO 129.A O no hydrogen 3.038 N/A ASP 134.A N PRO 130.A O no hydrogen 2.831 N/A ALA 135.A N ALA 131.A O no hydrogen 2.869 N/A TYR 136.A N LEU 132.A O no hydrogen 2.722 N/A TYR 136.A OH LEU 120.A O no hydrogen 2.412 N/A TYR 137.A N GLN 133.A O no hydrogen 3.083 N/A ARG 138.A N ASP 134.A O no hydrogen 3.083 N/A ALA 139.A N ALA 135.A O no hydrogen 2.795 N/A ARG 140.A N TYR 136.A O no hydrogen 2.882 N/A ALA 141.A N TYR 137.A O no hydrogen 3.093 N/A GLY 142.A N ALA 139.A O no hydrogen 2.900 N/A GLU 143.A N ARG 138.A O no hydrogen 2.961 N/A ASN 146.A ND2 TYR 83.A OH no hydrogen 2.656 N/A CYS 148.A N ALA 144.A O no hydrogen 2.945 N/A CYS 148.A SG TYR 95.A OH no hydrogen 3.622 N/A CYS 148.A SG ALA 144.A O no hydrogen 3.561 N/A ALA 149.A N ALA 145.A O no hydrogen 2.869 N/A LEU 150.A N ASN 146.A O no hydrogen 2.906 N/A ILE 151.A N PHE 147.A O no hydrogen 3.008 N/A LEU 152.A N CYS 148.A O no hydrogen 2.987 N/A ALA 153.A N ALA 149.A O no hydrogen 2.938 N/A TYR 154.A N LEU 150.A O no hydrogen 2.843 N/A TYR 154.A OH TYR 72.A O no hydrogen 2.407 N/A CYS 155.A N ILE 151.A O no hydrogen 2.923 N/A CYS 155.A SG ILE 151.A O no hydrogen 3.080 N/A ASN 156.A N ALA 153.A O no hydrogen 3.117 N/A LYS 157.A N LEU 152.A O no hydrogen 3.053 N/A THR 158.A N GLU 161.A OE1 no hydrogen 2.298 N/A THR 158.A OG1 GLU 161.A OE1 no hydrogen 2.513 N/A GLU 161.A N THR 158.A O no hydrogen 3.246 N/A VAL 165.A N TYR 273.A OH no hydrogen 3.008 N/A ARG 166.A N ASP 164.A OD1 no hydrogen 3.099 N/A THR 168.A N ASP 164.A O no hydrogen 3.194 N/A THR 168.A OG1 ASP 164.A O no hydrogen 3.120 N/A THR 168.A OG1 VAL 165.A O no hydrogen 2.626 N/A MET 169.A N VAL 165.A O no hydrogen 2.908 N/A SER 170.A N ARG 166.A O no hydrogen 3.059 N/A SER 170.A OG ARG 166.A O no hydrogen 3.272 N/A SER 170.A OG GLU 167.A O no hydrogen 2.654 N/A TYR 171.A N GLU 167.A O no hydrogen 2.934 N/A LEU 172.A N THR 168.A O no hydrogen 2.890 N/A PHE 173.A N MET 169.A O no hydrogen 2.760 N/A GLN 174.A N SER 170.A O no hydrogen 3.002 N/A GLN 174.A N TYR 171.A O no hydrogen 3.096 N/A HIS 175.A N LEU 172.A O no hydrogen 2.832 N/A ALA 176.A N PHE 173.A O no hydrogen 2.889 N/A ASN 177.A N LYS 126.A O no hydrogen 3.027 N/A ASP 179.A N ASN 177.A OD1 no hydrogen 3.000 N/A CYS 181.A N LEU 178.A O no hydrogen 2.841 N/A CYS 181.A SG SER 239.A OG no hydrogen 3.550 N/A LYS 182.A N GLU 238.A O no hydrogen 2.946 N/A ARG 183.A N LEU 199.A O no hydrogen 3.035 N/A ARG 183.A NE GLN 237.A OE1 no hydrogen 2.601 N/A ARG 183.A NH2 GLN 237.A OE1 no hydrogen 3.232 N/A VAL 184.A N GLN 236.A O no hydrogen 2.711 N/A LEU 185.A N THR 197.A O no hydrogen 2.863 N/A ASN 186.A N TYR 233.A O no hydrogen 3.310 N/A VAL 187.A N GLN 195.A O no hydrogen 2.938 N/A CYS 189.A N GLY 193.A O no hydrogen 2.866 N/A GLY 193.A N CYS 189.A O no hydrogen 2.903 N/A GLN 195.A N VAL 187.A O no hydrogen 2.935 N/A THR 197.A N LEU 185.A O no hydrogen 2.801 N/A LEU 199.A N ARG 183.A O no hydrogen 2.778 N/A ALA 204.A N GLY 201.A O no hydrogen 2.904 N/A VAL 205.A N VAL 202.A O no hydrogen 3.001 N/A MET 206.A N VAL 202.A O no hydrogen 3.045 N/A TYR 207.A N MET 243.A O no hydrogen 3.159 N/A GLY 209.A N SER 245.A O no hydrogen 2.517 N/A SER 212.A N THR 210.A OG1 no hydrogen 3.297 N/A TYR 213.A N TYR 305.A OH no hydrogen 3.432 N/A TYR 213.A OH GLU 307.A OE1 no hydrogen 2.526 N/A GLN 215.A N SER 212.A OG no hydrogen 2.933 N/A PHE 216.A N SER 212.A O no hydrogen 3.090 N/A LYS 217.A N TYR 213.A O no hydrogen 2.898 N/A LYS 218.A N GLU 214.A O no hydrogen 2.940 N/A GLY 219.A N GLN 215.A O no hydrogen 2.788 N/A VAL 220.A N LYS 232.A O no hydrogen 2.809 N/A ILE 222.A N ALA 230.A O no hydrogen 2.896 N/A CYS 224.A N LYS 228.A O no hydrogen 2.687 N/A GLY 227.A N CYS 224.A O no hydrogen 2.906 N/A ALA 230.A N ILE 222.A O no hydrogen 2.821 N/A LYS 232.A N VAL 220.A O no hydrogen 2.895 N/A TYR 233.A N ASN 186.A O no hydrogen 3.392 N/A LEU 234.A N PHE 216.A O no hydrogen 3.124 N/A VAL 235.A N VAL 184.A O no hydrogen 2.995 N/A GLN 236.A N VAL 184.A O no hydrogen 3.024 N/A GLN 237.A N TYR 310.A O no hydrogen 2.825 N/A GLN 237.A NE2 ALA 204.A O no hydrogen 2.889 N/A GLU 238.A N LYS 182.A O no hydrogen 3.007 N/A SER 239.A N ASN 308.A O no hydrogen 3.102 N/A SER 239.A OG PHE 241.A O no hydrogen 2.742 N/A PHE 241.A N SER 239.A OG no hydrogen 3.344 N/A VAL 242.A N TYR 305.A O no hydrogen 2.938 N/A MET 243.A N VAL 205.A O no hydrogen 3.030 N/A MET 244.A N VAL 303.A O no hydrogen 2.791 N/A SER 245.A N TYR 207.A O no hydrogen 3.114 N/A ALA 246.A N THR 301.A O no hydrogen 2.873 N/A ALA 249.A N ILE 300.A O no hydrogen 3.113 N/A TYR 251.A N GLY 298.A O no hydrogen 2.735 N/A HIS 255.A NE2 LYS 279.A O no hydrogen 3.066 N/A GLY 256.A N SER 278.A OG no hydrogen 2.991 N/A THR 257.A N LYS 254.A O no hydrogen 3.369 N/A THR 257.A OG1 LYS 254.A O no hydrogen 2.756 N/A THR 259.A N PHE 304.A O no hydrogen 2.881 N/A ALA 261.A N ILE 276.A O no hydrogen 2.789 N/A SER 262.A N ASP 302.A O no hydrogen 2.906 N/A GLU 263.A N LYS 274.A O no hydrogen 2.748 N/A TYR 264.A N PRO 299.A O no hydrogen 2.776 N/A TYR 264.A OH ASN 267.A O no hydrogen 2.393 N/A THR 265.A N HIS 272.A O no hydrogen 2.943 N/A ASN 267.A N CYS 270.A O no hydrogen 2.709 N/A GLN 269.A N ASN 267.A OD1 no hydrogen 2.735 N/A CYS 270.A N ASN 267.A O no hydrogen 3.242 N/A HIS 272.A N THR 265.A O no hydrogen 2.852 N/A HIS 272.A NE2 ASP 286.A OD2 no hydrogen 2.777 N/A TYR 273.A OH ASP 164.A OD1 no hydrogen 2.841 N/A LYS 274.A N GLU 263.A O no hydrogen 2.814 N/A HIS 275.A N ILE 285.A O no hydrogen 2.971 N/A ILE 276.A N ALA 261.A O no hydrogen 2.793 N/A THR 277.A N TYR 283.A O no hydrogen 2.857 N/A THR 277.A OG1 GLN 122.A OE1 no hydrogen 2.923 N/A SER 278.A N THR 259.A O no hydrogen 3.281 N/A LYS 279.A N THR 281.A O no hydrogen 2.765 N/A LYS 279.A NZ ASN 99.A O no hydrogen 2.934 N/A LYS 279.A NZ ASN 99.A OD1 no hydrogen 2.347 N/A GLU 280.A N GLU 280.A OE1 no hydrogen 2.713 N/A THR 281.A OG1 SER 293.A O no hydrogen 3.459 N/A LEU 282.A N SER 293.A O no hydrogen 2.996 N/A TYR 283.A N THR 277.A O no hydrogen 2.900 N/A TYR 283.A OH GLU 280.A OE2 no hydrogen 2.729 N/A CYS 284.A N THR 291.A O no hydrogen 2.874 N/A ILE 285.A N HIS 275.A O no hydrogen 2.867 N/A ASP 286.A N LEU 289.A O no hydrogen 2.747 N/A LEU 289.A N ASP 286.A O no hydrogen 2.969 N/A THR 291.A N CYS 284.A O no hydrogen 2.979 N/A SER 293.A N LEU 282.A O no hydrogen 2.803 N/A SER 293.A OG GLU 295.A O no hydrogen 2.290 N/A TYR 296.A N LEU 253.A O no hydrogen 3.184 N/A GLY 298.A N TYR 251.A O no hydrogen 2.975 N/A ILE 300.A N ALA 249.A O no hydrogen 2.893 N/A THR 301.A N SER 262.A O no hydrogen 2.935 N/A VAL 303.A N MET 244.A O no hydrogen 2.759 N/A PHE 304.A N CYS 260.A O no hydrogen 2.813 N/A TYR 305.A N VAL 242.A O no hydrogen 2.904 N/A TYR 305.A OH LEU 211.A O no hydrogen 2.279 N/A GLU 307.A N PRO 240.A O no hydrogen 3.203 N/A ASN 308.A N GLU 307.A OE2 no hydrogen 2.636 N/A TYR 310.A N GLN 237.A O no hydrogen 2.729 N/A THR 312.A N VAL 235.A O no hydrogen 2.480 N/A THR 312.A OG1 TYR 310.A OH no hydrogen 3.388 N/A ILE 314.A N THR 312.A OG1 no hydrogen 3.201 N/A