Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7esd_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLN 2.A N SER 1.A OG no hydrogen 2.408 N/A CYS 3.A SG SER 1.A O no hydrogen 3.253 N/A ARG 9.A NH1 THR 32.A OG1 no hydrogen 2.909 N/A ASP 10.A N CYS 30.A O no hydrogen 2.776 N/A ILE 12.A N THR 32.A O no hydrogen 3.339 N/A GLN 13.A NE2 GLN 13.A O no hydrogen 3.615 N/A VAL 23.A N CYS 289.A O no hydrogen 3.125 N/A LEU 25.A N LEU 287.A O no hydrogen 2.852 N/A CYS 30.A SG GLY 29.A O no hydrogen 3.153 N/A THR 32.A N ASP 10.A O no hydrogen 2.906 N/A THR 32.A OG1 ASP 42.A OD1 no hydrogen 2.707 N/A ILE 33.A N ILE 41.A O no hydrogen 2.816 N/A THR 40.A OG1 ILE 33.A O no hydrogen 2.628 N/A ILE 41.A N ILE 33.A O no hydrogen 2.805 N/A ASP 42.A N SER 142.A O no hydrogen 2.917 N/A ARG 44.A N ALA 140.A O no hydrogen 2.860 N/A VAL 46.A N THR 138.A O no hydrogen 2.897 N/A ALA 54.A N ALA 129.A O no hydrogen 3.202 N/A TYR 59.A N MET 125.A O no hydrogen 3.411 N/A CYS 60.A SG GLU 62.A O no hydrogen 3.342 N/A LEU 61.A N LYS 123.A O no hydrogen 2.800 N/A SER 64.A N ALA 120.A O no hydrogen 2.903 N/A SER 66.A N LYS 118.A O no hydrogen 3.411 N/A GLY 73.A N SER 112.A O no hydrogen 2.980 N/A GLU 79.A N GLU 79.A OE1 no hydrogen 2.579 N/A ALA 80.A N SER 112.A OG no hydrogen 2.901 N/A ASN 82.A N ASP 114.A OD2 no hydrogen 2.871 N/A ASN 82.A ND2 ASP 114.A O no hydrogen 3.237 N/A LYS 84.A N ASN 82.A OD1 no hydrogen 3.363 N/A ARG 85.A N ASN 82.A O no hydrogen 3.095 N/A ARG 85.A NE ASP 114.A OD1 no hydrogen 3.305 N/A ARG 85.A NE ASP 114.A OD2 no hydrogen 3.063 N/A ARG 85.A NH2 ASP 114.A OD1 no hydrogen 2.636 N/A ARG 85.A NH2 ASP 114.A OD2 no hydrogen 3.397 N/A TYR 90.A N ASP 87.A O no hydrogen 3.151 N/A LEU 91.A N VAL 117.A O no hydrogen 2.759 N/A GLU 93.A N THR 115.A O no hydrogen 3.409 N/A SER 95.A N LEU 113.A O no hydrogen 3.237 N/A GLY 100.A N ASN 103.A OD1 no hydrogen 2.837 N/A GLY 104.A N TRP 101.A O no hydrogen 3.255 N/A CYS 105.A N GLY 100.A O no hydrogen 3.398 N/A GLY 109.A N ARG 99.A O no hydrogen 3.437 N/A GLY 111.A N PRO 97.A O no hydrogen 2.942 N/A SER 112.A N GLY 73.A O no hydrogen 3.187 N/A LEU 113.A N SER 95.A O no hydrogen 2.578 N/A ASP 114.A N VAL 71.A O no hydrogen 3.291 N/A THR 115.A N GLU 93.A O no hydrogen 3.420 N/A THR 115.A OG1 GLN 249.A OE1 no hydrogen 2.638 N/A VAL 117.A N LEU 91.A O no hydrogen 2.686 N/A LYS 118.A N GLU 67.A O no hydrogen 3.146 N/A PHE 119.A N THR 89.A O no hydrogen 3.108 N/A CYS 121.A SG GLU 62.A O no hydrogen 3.287 N/A CYS 121.A SG LYS 123.A O no hydrogen 3.225 N/A SER 122.A OG GLU 62.A OE1 no hydrogen 2.241 N/A LYS 123.A NZ ASP 256.A OD2 no hydrogen 3.196 N/A LYS 123.A NZ GLU 258.A OE1 no hydrogen 2.404 N/A ALA 129.A N ALA 54.A O no hydrogen 2.673 N/A ASN 134.A ND2 ASN 52.A O no hydrogen 3.487 N/A VAL 136.A N GLU 49.A O no hydrogen 3.060 N/A THR 138.A N LYS 47.A O no hydrogen 3.206 N/A ALA 139.A N LEU 166.A O no hydrogen 3.230 N/A ALA 140.A N ARG 44.A O no hydrogen 2.758 N/A VAL 141.A N ALA 164.A O no hydrogen 3.244 N/A SER 142.A N ASP 42.A O no hydrogen 2.821 N/A HIS 144.A N THR 40.A O no hydrogen 3.088 N/A HIS 144.A NE2 ASP 42.A OD2 no hydrogen 2.313 N/A SER 147.A OG ILE 361.A O no hydrogen 2.783 N/A SER 147.A OG ILE 362.A O no hydrogen 3.133 N/A ASP 153.A N GLN 156.A OE1 no hydrogen 3.426 N/A ARG 157.A N ASP 153.A O no hydrogen 2.938 N/A LYS 158.A N ARG 154.A O no hydrogen 2.876 N/A SER 159.A N SER 155.A O no hydrogen 2.905 N/A ARG 160.A N GLN 156.A O no hydrogen 2.916 N/A LYS 161.A N LYS 158.A O no hydrogen 2.900 N/A GLU 162.A N ARG 157.A O no hydrogen 3.187 N/A LEU 166.A N ALA 139.A O no hydrogen 2.829 N/A LEU 166.A N GLU 165.A OE2 no hydrogen 3.340 N/A THR 167.A OG1 THR 167.A O no hydrogen 2.583 N/A ILE 168.A N ILE 137.A O no hydrogen 2.699 N/A SER 172.A OG SER 172.A O no hydrogen 2.370 N/A ALA 177.A N VAL 185.A O no hydrogen 2.863 N/A TYR 182.A N LEU 179.A O no hydrogen 3.304 N/A GLY 183.A N GLY 180.A O no hydrogen 3.409 N/A GLN 186.A N GLN 186.A OE1 no hydrogen 2.479 N/A TYR 201.A N VAL 212.A O no hydrogen 2.874 N/A THR 202.A N HIS 128.A O no hydrogen 3.209 N/A ASP 204.A N ALA 126.A O no hydrogen 3.069 N/A MET 205.A N LYS 208.A O no hydrogen 3.304 N/A GLY 207.A N ASP 204.A OD1 no hydrogen 3.104 N/A ARG 214.A N ASP 199.A O no hydrogen 3.288 N/A TYR 217.A N LYS 213.A O no hydrogen 2.943 N/A TYR 217.A OH ARG 57.A O no hydrogen 2.347 N/A TYR 217.A OH MET 125.A O no hydrogen 3.193 N/A HIS 218.A N ARG 214.A O no hydrogen 2.890 N/A ASP 219.A N ASP 215.A O no hydrogen 2.923 N/A ASP 219.A N TRP 216.A O no hydrogen 3.249 N/A THR 225.A OG1 ALA 229.A O no hydrogen 3.082 N/A ALA 226.A N THR 225.A OG1 no hydrogen 2.600 N/A ASP 230.A N ASP 230.A OD1 no hydrogen 2.475 N/A PHE 231.A N THR 225.A OG1 no hydrogen 2.437 N/A HIS 233.A N TRP 224.A O no hydrogen 3.242 N/A GLU 240.A N TYR 252.A O no hydrogen 2.819 N/A SER 242.A N SER 250.A O no hydrogen 3.037 N/A SER 242.A OG SER 250.A O no hydrogen 2.401 N/A SER 242.A OG SER 250.A OG no hydrogen 2.463 N/A THR 247.A OG1 ALA 246.A O no hydrogen 2.748 N/A GLN 249.A NE2 SER 242.A O no hydrogen 3.296 N/A SER 250.A N SER 242.A OG no hydrogen 2.979 N/A SER 250.A OG SER 242.A OG no hydrogen 2.463 N/A TYR 252.A N GLU 240.A O no hydrogen 3.168 N/A THR 253.A OG1 LEU 238.A O no hydrogen 3.329 N/A LEU 254.A N THR 253.A OG1 no hydrogen 2.591 N/A MET 261.A N GLN 257.A O no hydrogen 2.901 N/A SER 262.A N GLU 258.A O no hydrogen 2.899 N/A SER 262.A OG GLU 258.A O no hydrogen 3.501 N/A SER 262.A OG GLY 259.A O no hydrogen 3.028 N/A THR 263.A N GLY 259.A O no hydrogen 2.901 N/A THR 263.A OG1 GLY 259.A O no hydrogen 3.293 N/A ALA 264.A N ALA 260.A O no hydrogen 2.897 N/A LEU 265.A N MET 261.A O no hydrogen 2.918 N/A GLU 272.A N VAL 281.A O no hydrogen 3.291 N/A MET 274.A N LYS 279.A O no hydrogen 2.726 N/A SER 276.A OG SER 275.A O no hydrogen 2.725 N/A SER 276.A OG SER 276.A O no hydrogen 2.381 N/A SER 278.A OG SER 51.A O no hydrogen 3.124 N/A SER 278.A OG GLY 277.A O no hydrogen 2.504 N/A LYS 279.A N MET 274.A O no hydrogen 3.125 N/A PHE 282.A N MET 48.A O no hydrogen 3.057 N/A THR 284.A OG1 PHE 282.A O no hydrogen 2.576 N/A LEU 287.A N LEU 25.A O no hydrogen 3.194 N/A LYS 288.A NZ ASP 425.A OD2 no hydrogen 2.572 N/A LYS 292.A N GLN 186.A O no hydrogen 3.212 N/A MET 293.A N THR 19.A O no hydrogen 2.676 N/A GLU 294.A N LYS 292.A O no hydrogen 3.037 N/A ARG 297.A N TYR 182.A O no hydrogen 2.924 N/A LYS 299.A NZ ASP 181.A OD2 no hydrogen 2.542 N/A CYS 306.A N ARG 338.A O no hydrogen 3.288 N/A SER 307.A N ASP 334.A OD2 no hydrogen 3.499 N/A SER 307.A OG ASP 334.A OD2 no hydrogen 3.534 N/A SER 311.A N LYS 329.A O no hydrogen 2.981 N/A LEU 313.A N GLN 327.A O no hydrogen 3.039 N/A ARG 315.A NH1 GLU 393.A OE2 no hydrogen 2.885 N/A THR 317.A N ILE 325.A O no hydrogen 3.353 N/A THR 319.A N THR 323.A O no hydrogen 3.233 N/A THR 319.A OG1 THR 323.A O no hydrogen 2.503 N/A THR 319.A OG1 THR 323.A OG1 no hydrogen 2.837 N/A GLY 322.A N THR 319.A OG1 no hydrogen 3.421 N/A THR 323.A N THR 319.A OG1 no hydrogen 2.679 N/A THR 323.A OG1 THR 319.A OG1 no hydrogen 2.837 N/A THR 323.A OG1 GLU 372.A OE2 no hydrogen 2.509 N/A VAL 324.A N VAL 373.A O no hydrogen 2.698 N/A ILE 325.A N THR 317.A O no hydrogen 3.327 N/A MET 326.A N ILE 371.A O no hydrogen 2.773 N/A VAL 328.A N LEU 369.A O no hydrogen 3.034 N/A LYS 329.A N SER 311.A O no hydrogen 2.944 N/A TYR 330.A N ASP 367.A O no hydrogen 3.430 N/A TYR 330.A OH ASP 334.A OD1 no hydrogen 2.550 N/A ALA 331.A N GLN 332.A OE1 no hydrogen 3.081 N/A GLN 332.A NE2 GLU 309.A O no hydrogen 3.045 N/A CYS 337.A SG ASP 334.A O no hydrogen 3.702 N/A ARG 338.A N MET 304.A O no hydrogen 3.199 N/A ARG 338.A NE TYR 303.A O no hydrogen 2.725 N/A ARG 338.A NH2 TYR 303.A O no hydrogen 3.439 N/A VAL 339.A N PRO 360.A O no hydrogen 3.028 N/A GLY 342.A N GLU 383.A O no hydrogen 2.890 N/A HIS 344.A N VAL 381.A O no hydrogen 3.106 N/A GLU 350.A N GLU 350.A OE2 no hydrogen 2.535 N/A VAL 352.A N VAL 343.A O no hydrogen 2.855 N/A ARG 354.A N GLU 374.A O no hydrogen 3.232 N/A ILE 361.A N HIS 359.A O no hydrogen 2.786 N/A ILE 362.A N CYS 337.A O no hydrogen 3.198 N/A GLN 365.A NE2 ALA 331.A O no hydrogen 2.721 N/A ALA 368.A N GLY 148.A O no hydrogen 2.899 N/A LEU 369.A N VAL 328.A O no hydrogen 2.754 N/A ILE 371.A N MET 326.A O no hydrogen 2.975 N/A VAL 373.A N VAL 324.A O no hydrogen 3.153 N/A GLU 374.A N ARG 354.A O no hydrogen 3.063 N/A SER 380.A N TRP 395.A O no hydrogen 3.079 N/A VAL 381.A N HIS 344.A O no hydrogen 2.727 N/A ILE 382.A N GLU 393.A O no hydrogen 2.705 N/A GLU 383.A N GLY 342.A O no hydrogen 2.913 N/A ILE 384.A N ILE 391.A O no hydrogen 2.875 N/A GLY 385.A N PRO 340.A O no hydrogen 3.355 N/A ILE 391.A N ILE 384.A O no hydrogen 2.754 N/A TRP 395.A N SER 380.A O no hydrogen 2.890 N/A ALA 404.A N SER 400.A O no hydrogen 3.343 N/A ALA 405.A N SER 401.A O no hydrogen 2.913 N/A PHE 406.A N ILE 402.A O no hydrogen 2.899 N/A THR 407.A N GLY 403.A O no hydrogen 2.895 N/A THR 407.A OG1 GLY 403.A O no hydrogen 3.044 N/A THR 407.A OG1 ALA 404.A O no hydrogen 2.558 N/A SER 408.A N ALA 404.A O no hydrogen 2.890 N/A THR 409.A N ALA 405.A O no hydrogen 2.909 N/A THR 409.A OG1 ALA 405.A O no hydrogen 3.460 N/A MET 410.A N PHE 406.A O no hydrogen 2.904 N/A LYS 411.A N THR 407.A O no hydrogen 2.891 N/A GLY 412.A N SER 408.A O no hydrogen 2.897 N/A VAL 413.A N THR 409.A O no hydrogen 2.918 N/A GLU 414.A N MET 410.A O no hydrogen 2.915 N/A ARG 415.A N LYS 411.A O no hydrogen 2.879 N/A ALA 417.A N GLY 412.A O no hydrogen 3.121 N/A LEU 418.A N ARG 415.A O no hydrogen 3.263 N/A HIS 422.A N LEU 419.A O no hydrogen 3.472 N/A HIS 422.A ND1 LEU 419.A O no hydrogen 2.786 N/A HIS 422.A NE2 ASP 192.A OD2 no hydrogen 2.875 N/A ALA 423.A N GLY 420.A O no hydrogen 3.270 N/A SER 435.A OG PHE 432.A O no hydrogen 2.973 N/A MET 436.A N PHE 432.A O no hydrogen 2.913 N/A GLY 437.A N PHE 433.A O no hydrogen 2.922 N/A LYS 438.A N ASN 434.A O no hydrogen 2.899 N/A ALA 439.A N SER 435.A O no hydrogen 2.901 N/A ILE 440.A N MET 436.A O no hydrogen 2.932 N/A HIS 441.A N GLY 437.A O no hydrogen 2.894 N/A SER 442.A N LYS 438.A O no hydrogen 2.906 N/A SER 442.A OG ALA 439.A O no hydrogen 2.947 N/A PHE 444.A N ILE 440.A O no hydrogen 2.962 N/A GLY 445.A N HIS 441.A O no hydrogen 2.843 N/A GLY 446.A N SER 442.A O no hydrogen 2.913 N/A LEU 447.A N VAL 443.A O no hydrogen 2.932 N/A TRP 457.A NE1 SER 494.A O no hydrogen 3.256 N/A LYS 460.A N SER 456.A O no hydrogen 2.860 N/A VAL 461.A N TRP 457.A O no hydrogen 2.936 N/A LEU 462.A N ILE 458.A O no hydrogen 2.945 N/A ILE 463.A N SER 459.A O no hydrogen 2.914 N/A GLY 464.A N LYS 460.A O no hydrogen 2.860 N/A ALA 465.A N VAL 461.A O no hydrogen 2.918 N/A ILE 466.A N LEU 462.A O no hydrogen 2.969 N/A LEU 467.A N ILE 463.A O no hydrogen 2.863 N/A MET 468.A N GLY 464.A O no hydrogen 2.922 N/A TRP 469.A N ALA 465.A O no hydrogen 2.983 N/A LEU 470.A N ILE 466.A O no hydrogen 2.901 N/A GLY 471.A N LEU 467.A O no hydrogen 2.878 N/A VAL 472.A N MET 468.A O no hydrogen 2.890 N/A SER 473.A N TRP 469.A O no hydrogen 2.947 N/A SER 473.A OG TRP 469.A O no hydrogen 3.103 N/A SER 473.A OG SER 473.A O no hydrogen 2.425 N/A ALA 480.A N LYS 477.A O no hydrogen 3.458 N/A SER 482.A N LEU 479.A O no hydrogen 3.168 N/A SER 482.A OG LEU 479.A O no hydrogen 3.207 N/A LEU 483.A N LEU 479.A O no hydrogen 2.907 N/A THR 485.A OG1 MET 481.A O no hydrogen 3.133 N/A VAL 486.A N SER 482.A O no hydrogen 2.730 N/A TYR 492.A N ALA 488.A O no hydrogen 2.905 N/A LEU 493.A N ILE 489.A O no hydrogen 2.902 N/A SER 494.A N LEU 490.A O no hydrogen 2.888 N/A SER 494.A OG LEU 491.A O no hydrogen 2.723 N/A THR 495.A N LEU 491.A O no hydrogen 2.911 N/A THR 495.A OG1 LEU 491.A O no hydrogen 2.870 N/A THR 495.A OG1 TYR 492.A O no hydrogen 3.001 N/A MET 496.A N TYR 492.A O no hydrogen 2.921 N/A THR 497.A OG1 LEU 493.A O no hydrogen 3.371 N/A