Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7sx8_D.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 3.A N GLU 3.A OE1 no hydrogen 2.785 N/A TYR 7.A N GLU 4.A OE2 no hydrogen 2.816 N/A PHE 9.A N LYS 6.A O no hydrogen 3.285 N/A VAL 10.A N TYR 7.A O no hydrogen 3.072 N/A ASN 11.A ND2 ASN 30.A O no hydrogen 3.007 N/A TRP 12.A N ALA 8.A O no hydrogen 2.942 N/A ILE 13.A N PHE 9.A O no hydrogen 2.881 N/A ASN 14.A N VAL 10.A O no hydrogen 2.898 N/A ASN 14.A ND2 VAL 10.A O no hydrogen 2.685 N/A ASN 14.A ND2 PRO 28.A O no hydrogen 2.441 N/A LYS 15.A N ASN 11.A O no hydrogen 2.928 N/A LYS 15.A NZ GLU 18.A OE1 no hydrogen 3.483 N/A LYS 15.A NZ GLU 18.A OE2 no hydrogen 2.842 N/A ALA 16.A N TRP 12.A O no hydrogen 2.923 N/A LEU 17.A N ILE 13.A O no hydrogen 2.848 N/A ASN 19.A ND2 ALA 16.A O no hydrogen 3.577 N/A ASN 19.A ND2 ASP 164.A OD2 no hydrogen 2.865 N/A ASP 20.A N LEU 17.A O no hydrogen 3.043 N/A ASP 22.A N ASP 20.A OD1 no hydrogen 3.414 N/A CYS 23.A N ASP 20.A O no hydrogen 3.099 N/A CYS 23.A SG ASP 20.A OD2 no hydrogen 3.040 N/A CYS 23.A SG VAL 45.A O no hydrogen 3.828 N/A ARG 24.A N PRO 21.A O no hydrogen 3.035 N/A ARG 24.A NH2 MET 29.A O no hydrogen 2.557 N/A HIS 25.A N ASP 22.A O no hydrogen 3.292 N/A HIS 25.A ND1 GLU 60.A OE1 no hydrogen 2.868 N/A VAL 26.A N CYS 23.A O no hydrogen 2.859 N/A ILE 27.A N CYS 23.A O no hydrogen 2.939 N/A ASN 30.A ND2 MET 29.A O no hydrogen 2.559 N/A ASN 32.A ND2 ASN 11.A OD1 no hydrogen 3.181 N/A THR 33.A N PRO 31.A O no hydrogen 2.627 N/A THR 33.A OG1 PRO 31.A O no hydrogen 3.524 N/A LYS 38.A NZ ASP 42.A OD1 no hydrogen 3.463 N/A LYS 38.A NZ ASP 42.A OD2 no hydrogen 3.361 N/A VAL 40.A N LEU 36.A O no hydrogen 2.892 N/A GLY 41.A N PHE 37.A O no hydrogen 2.915 N/A ASP 42.A N LYS 38.A O no hydrogen 3.297 N/A ASP 42.A N ALA 39.A O no hydrogen 3.050 N/A GLY 43.A N VAL 40.A O no hydrogen 2.815 N/A ILE 44.A N ALA 39.A O no hydrogen 3.517 N/A LEU 46.A N GLY 43.A O no hydrogen 3.222 N/A CYS 47.A SG GLY 43.A O no hydrogen 3.794 N/A CYS 47.A SG ALA 80.A O no hydrogen 3.223 N/A LYS 48.A N ILE 44.A O no hydrogen 3.070 N/A LYS 48.A NZ ASP 22.A O no hydrogen 2.872 N/A LYS 48.A NZ ASP 22.A OD2 no hydrogen 2.371 N/A LYS 48.A NZ HIS 25.A ND1 no hydrogen 3.343 N/A LYS 48.A NZ GLU 60.A OE1 no hydrogen 2.315 N/A MET 49.A N VAL 45.A O no hydrogen 2.890 N/A ASN 51.A N LYS 48.A O no hydrogen 2.936 N/A ASN 51.A ND2 LYS 48.A O no hydrogen 2.384 N/A LEU 52.A N MET 49.A O no hydrogen 3.256 N/A ILE 58.A N THR 57.A OG1 no hydrogen 2.719 N/A ARG 61.A NE ASN 64.A O no hydrogen 3.427 N/A ARG 61.A NH2 ASN 64.A O no hydrogen 3.348 N/A ALA 62.A N ASP 59.A O no hydrogen 3.150 N/A ILE 63.A N ASP 59.A O no hydrogen 3.154 N/A LYS 66.A NZ LEU 68.A O no hydrogen 2.352 N/A ASN 76.A ND2 ASP 42.A OD2 no hydrogen 2.783 N/A ALA 80.A N ASN 76.A O no hydrogen 2.914 N/A LEU 81.A N LEU 77.A O no hydrogen 2.910 N/A ASN 82.A N ASN 78.A O no hydrogen 3.037 N/A SER 83.A N ALA 80.A O no hydrogen 3.394 N/A ALA 84.A N LEU 81.A O no hydrogen 3.285 N/A GLY 88.A N ALA 86.A O no hydrogen 2.370 N/A LEU 99.A N GLY 95.A O no hydrogen 3.318 N/A ARG 100.A NH1 GLU 97.A OE2 no hydrogen 2.627 N/A ARG 100.A NH2 GLU 97.A OE1 no hydrogen 3.267 N/A ARG 100.A NH2 GLU 97.A OE2 no hydrogen 3.317 N/A ALA 101.A N ASP 98.A O no hydrogen 3.372 N/A GLY 102.A N ASP 98.A O no hydrogen 3.065 N/A VAL 107.A N LYS 103.A O no hydrogen 2.869 N/A LEU 108.A N PRO 104.A O no hydrogen 2.914 N/A GLY 109.A N HIS 105.A O no hydrogen 2.879 N/A LEU 110.A N LEU 106.A O no hydrogen 2.966 N/A LEU 111.A N VAL 107.A O no hydrogen 2.864 N/A TRP 112.A N LEU 108.A O no hydrogen 2.899 N/A ILE 114.A N LEU 110.A O no hydrogen 2.998 N/A ILE 115.A N LEU 111.A O no hydrogen 2.853 N/A LYS 116.A N TRP 112.A O no hydrogen 2.906 N/A ILE 117.A N GLN 113.A O no hydrogen 2.953 N/A GLY 118.A N ILE 114.A O no hydrogen 2.887 N/A LEU 126.A N GLU 122.A O no hydrogen 2.883 N/A ARG 127.A N GLU 123.A O no hydrogen 2.924 N/A ARG 127.A NH2 GLU 123.A OE1 no hydrogen 2.308 N/A ALA 129.A N LEU 126.A O no hydrogen 2.977 N/A ASN 130.A N LEU 126.A O no hydrogen 2.912 N/A ASN 130.A ND2 ASN 142.A O no hydrogen 3.007 N/A PHE 131.A N ARG 127.A O no hydrogen 2.933 N/A LEU 133.A N ASN 130.A O no hydrogen 3.005 N/A TRP 138.A N GLU 134.A OE2 no hydrogen 3.020 N/A ASN 142.A ND2 ASP 147.A OD2 no hydrogen 2.694 N/A PHE 144.A N ASN 143.A OD1 no hydrogen 2.486 N/A SER 145.A OG GLY 192.A O no hydrogen 2.712 N/A ALA 146.A N ASN 143.A O no hydrogen 3.227 N/A LYS 152.A NZ ASP 150.A OD2 no hydrogen 2.333 N/A PHE 155.A N SER 151.A O no hydrogen 2.889 N/A HIS 156.A N LYS 152.A O no hydrogen 2.939 N/A LEU 157.A N ALA 153.A O no hydrogen 2.935 N/A LEU 158.A N TYR 154.A O no hydrogen 2.816 N/A ASN 159.A N PHE 155.A O no hydrogen 2.952 N/A GLN 160.A N LEU 157.A O no hydrogen 2.983 N/A ILE 161.A N LEU 157.A O no hydrogen 2.916 N/A ILE 161.A N LEU 158.A O no hydrogen 3.187 N/A ASP 164.A N ASN 19.A OD1 no hydrogen 2.921 N/A LEU 165.A N ASP 163.A OD1 no hydrogen 3.039 N/A LYS 166.A N ASP 163.A O no hydrogen 2.786 N/A LYS 166.A NZ ASP 163.A OD2 no hydrogen 2.828 N/A ARG 167.A N ASP 163.A O no hydrogen 2.502 N/A ARG 167.A NH1 LYS 15.A O no hydrogen 3.371 N/A ARG 167.A NH1 ASP 164.A OD1 no hydrogen 2.351 N/A ARG 167.A NH2 LYS 15.A O no hydrogen 3.250 N/A ALA 168.A N ASP 164.A O no hydrogen 2.891 N/A GLU 169.A N LYS 166.A O no hydrogen 3.263 N/A SER 170.A N ARG 167.A O no hydrogen 3.220 N/A SER 170.A OG ARG 167.A O no hydrogen 3.054 N/A LEU 172.A N ALA 168.A O no hydrogen 2.923 N/A GLN 173.A NE2 SER 170.A O no hydrogen 2.900 N/A GLN 174.A NE2 MET 171.A O no hydrogen 2.589 N/A ALA 175.A N LEU 172.A O no hydrogen 2.821 N/A ASP 176.A N LEU 172.A O no hydrogen 2.633 N/A LEU 178.A N ALA 175.A O no hydrogen 3.365 N/A GLY 179.A N ASP 176.A O no hydrogen 3.388 N/A CYS 180.A N ALA 175.A O no hydrogen 3.077 N/A CYS 180.A SG LEU 178.A O no hydrogen 3.995 N/A THR 185.A OG1 ASP 188.A OD2 no hydrogen 2.584 N/A VAL 189.A N THR 185.A O no hydrogen 2.823 N/A VAL 190.A N PRO 186.A O no hydrogen 2.900 N/A SER 191.A N ALA 187.A O no hydrogen 2.989 N/A SER 191.A OG ALA 187.A O no hydrogen 2.510 N/A GLY 192.A N VAL 189.A O no hydrogen 3.354 N/A ASN 193.A N ASP 188.A O no hydrogen 2.952 N/A ASN 193.A ND2 ASP 188.A OD1 no hydrogen 3.372 N/A LEU 196.A N ASN 193.A OD1 no hydrogen 3.530 N/A ASN 197.A N ASN 193.A O no hydrogen 3.285 N/A ASN 197.A ND2 ASN 193.A O no hydrogen 2.277 N/A LEU 198.A N PRO 194.A O no hydrogen 2.909 N/A PHE 200.A N LEU 196.A O no hydrogen 3.289 N/A VAL 201.A N ASN 197.A O no hydrogen 3.025 N/A ALA 202.A N LEU 198.A O no hydrogen 2.911 N/A ASN 203.A N ALA 199.A O no hydrogen 2.924 N/A TYR 208.A N PHE 205.A O no hydrogen 3.298 N/A THR 212.A OG1 ASP 210.A OD1 no hydrogen 3.243 N/A GLU 215.A N GLU 215.A OE1 no hydrogen 2.706 N/A THR 218.A N GLU 221.A OE1 no hydrogen 3.138 N/A ARG 222.A N THR 218.A O no hydrogen 3.023 N/A ARG 222.A NH1 THR 212.A O no hydrogen 2.327 N/A THR 223.A N ARG 219.A O no hydrogen 2.894 N/A THR 223.A OG1 ARG 219.A O no hydrogen 2.713 N/A PHE 224.A N GLU 220.A O no hydrogen 2.943 N/A ARG 225.A N GLU 221.A O no hydrogen 2.908 N/A ASN 226.A N ARG 222.A O no hydrogen 2.908 N/A TRP 227.A N THR 223.A O no hydrogen 2.902 N/A MET 228.A N PHE 224.A O no hydrogen 3.006 N/A ASN 229.A N ARG 225.A O no hydrogen 2.902 N/A ASN 229.A ND2 VAL 237.A O no hydrogen 3.572 N/A SER 230.A N ASN 226.A O no hydrogen 2.884 N/A SER 230.A OG ASN 226.A O no hydrogen 2.773 N/A LEU 231.A N TRP 227.A O no hydrogen 2.925 N/A ASN 234.A N GLN 252.A OE1 no hydrogen 3.180 N/A HIS 236.A ND1 ASN 238.A OD1 no hydrogen 2.814 N/A ASN 238.A N ASP 243.A OD2 no hydrogen 2.771 N/A HIS 239.A N ASP 243.A OD2 no hydrogen 3.100 N/A TYR 241.A OH GLU 221.A OE2 no hydrogen 2.431 N/A ALA 242.A N HIS 239.A O no hydrogen 3.452 N/A ASP 243.A N HIS 239.A O no hydrogen 3.106 N/A GLN 245.A NE2 TYR 241.A O no hydrogen 3.152 N/A ALA 247.A N LEU 244.A O no hydrogen 3.296 N/A LEU 248.A N ASP 246.A OD1 no hydrogen 3.449 N/A LEU 251.A N ALA 247.A O no hydrogen 3.176 N/A GLN 252.A N LEU 248.A O no hydrogen 2.918 N/A LEU 253.A N VAL 249.A O no hydrogen 2.900 N/A TYR 254.A N ILE 250.A O no hydrogen 2.920 N/A TYR 254.A N LEU 251.A O no hydrogen 3.064 N/A TYR 254.A OH ALA 287.A O no hydrogen 2.915 N/A ARG 256.A N LEU 253.A O no hydrogen 3.200 N/A ILE 257.A N TYR 254.A O no hydrogen 3.207 N/A LYS 258.A N GLU 255.A O no hydrogen 3.153 N/A VAL 259.A N TYR 254.A O no hydrogen 3.075 N/A SER 264.A OG ASP 262.A OD2 no hydrogen 2.313 N/A LYS 265.A N ASP 262.A O no hydrogen 3.439 N/A VAL 266.A N TRP 263.A O no hydrogen 3.268 N/A LYS 279.A N GLY 275.A O no hydrogen 2.998 N/A LYS 280.A N ALA 276.A O no hydrogen 2.918 N/A LEU 281.A N ASN 277.A O no hydrogen 2.900 N/A GLU 282.A N MET 278.A O no hydrogen 2.881 N/A ASN 283.A N LYS 279.A O no hydrogen 2.896 N/A CYS 284.A N LYS 280.A O no hydrogen 2.927 N/A CYS 284.A SG GLN 245.A O no hydrogen 3.223 N/A CYS 284.A SG LYS 280.A O no hydrogen 3.320 N/A ASN 285.A N LEU 281.A O no hydrogen 2.908 N/A TYR 286.A N GLU 282.A O no hydrogen 2.888 N/A TYR 286.A OH GLU 282.A OE2 no hydrogen 3.008 N/A ALA 287.A N ASN 283.A O no hydrogen 2.906 N/A VAL 288.A N CYS 284.A O no hydrogen 2.938 N/A GLU 289.A N ASN 285.A O no hydrogen 2.899 N/A LEU 290.A N TYR 286.A O no hydrogen 2.878 N/A GLY 291.A N ALA 287.A O no hydrogen 2.921 N/A LYS 292.A N VAL 288.A O no hydrogen 2.923 N/A LYS 292.A N GLU 289.A O no hydrogen 3.222 N/A LYS 292.A NZ LEU 299.A O no hydrogen 2.357 N/A HIS 293.A N GLU 289.A O no hydrogen 3.425 N/A LYS 296.A N LYS 292.A O no hydrogen 3.080 N/A LYS 296.A NZ HIS 293.A O no hydrogen 3.281 N/A PHE 297.A N GLY 291.A O no hydrogen 3.267 N/A GLY 303.A N ASP 306.A OD2 no hydrogen 2.420 N/A GLN 305.A N GLN 305.A OE1 no hydrogen 3.032 N/A ASP 306.A N GLY 303.A O no hydrogen 3.289 N/A ASN 308.A N GLY 304.A O no hydrogen 2.910 N/A ASP 309.A N GLN 305.A O no hydrogen 2.719 N/A GLY 310.A N LEU 307.A O no hydrogen 3.244 N/A ASN 311.A N ASP 306.A O no hydrogen 2.840 N/A THR 313.A OG1 GLN 312.A OE1 no hydrogen 2.408 N/A LEU 314.A N ASN 311.A OD1 no hydrogen 3.429 N/A THR 315.A N ASN 311.A O no hydrogen 3.086 N/A THR 315.A OG1 ASN 311.A O no hydrogen 2.656 N/A LEU 316.A N GLN 312.A O no hydrogen 2.921 N/A ALA 317.A N THR 313.A O no hydrogen 2.924 N/A LEU 318.A N LEU 314.A O no hydrogen 3.194 N/A LEU 318.A N THR 315.A O no hydrogen 3.198 N/A VAL 319.A N THR 315.A O no hydrogen 2.942 N/A TRP 320.A N LEU 316.A O no hydrogen 2.970 N/A GLN 321.A NE2 SER 298.A O no hydrogen 3.391 N/A GLN 321.A NE2 ALA 317.A O no hydrogen 2.584 N/A LEU 322.A N LEU 318.A O no hydrogen 2.913 N/A MET 323.A N VAL 319.A O no hydrogen 2.961 N/A ARG 324.A N TRP 320.A O no hydrogen 2.916 N/A ARG 325.A N GLN 321.A O no hydrogen 2.996 N/A ARG 325.A NH1 GLN 321.A OE1 no hydrogen 3.450 N/A TYR 326.A N LEU 322.A O no hydrogen 2.894 N/A THR 327.A N MET 323.A O no hydrogen 2.832 N/A THR 327.A OG1 MET 323.A O no hydrogen 3.018 N/A THR 327.A OG1 TYR 422.A OH no hydrogen 3.205 N/A LEU 328.A N ARG 324.A O no hydrogen 2.947 N/A ASN 329.A N ARG 325.A O no hydrogen 2.875 N/A VAL 330.A N TYR 326.A O no hydrogen 2.928 N/A LEU 331.A N THR 327.A O no hydrogen 2.914 N/A GLU 332.A N LEU 328.A O no hydrogen 2.882 N/A GLU 332.A N ASN 329.A O no hydrogen 3.214 N/A ASP 333.A N ASN 329.A O no hydrogen 2.923 N/A GLY 335.A N GLU 332.A O no hydrogen 3.256 N/A GLY 337.A N ASP 336.A OD1 no hydrogen 2.642 N/A ASP 342.A N ASN 341.A OD1 no hydrogen 2.620 N/A ASN 350.A ND2 ILE 362.A O no hydrogen 3.261 N/A ARG 351.A N ASN 347.A O no hydrogen 2.917 N/A THR 352.A N TRP 348.A O no hydrogen 2.881 N/A LEU 353.A N VAL 349.A O no hydrogen 3.136 N/A SER 354.A N ARG 351.A O no hydrogen 3.293 N/A SER 354.A OG ARG 351.A O no hydrogen 2.426 N/A GLU 355.A N THR 352.A O no hydrogen 3.415 N/A GLY 357.A N LEU 353.A O no hydrogen 2.885 N/A LYS 358.A NZ TYR 390.A OH no hydrogen 2.755 N/A ILE 362.A N ASN 350.A OD1 no hydrogen 3.281 N/A PHE 365.A N SER 364.A OG no hydrogen 2.701 N/A THR 369.A N ASP 367.A OD1 no hydrogen 3.123 N/A SER 371.A N LYS 368.A O no hydrogen 3.224 N/A SER 371.A OG VAL 429.A O no hydrogen 3.274 N/A SER 373.A OG ASN 406.A OD1 no hydrogen 2.478 N/A VAL 377.A N SER 373.A O no hydrogen 3.088 N/A ASP 378.A N LEU 374.A O no hydrogen 2.916 N/A LEU 379.A N VAL 376.A O no hydrogen 3.218 N/A ILE 380.A N VAL 376.A O no hydrogen 2.904 N/A ALA 382.A N LEU 379.A O no hydrogen 2.981 N/A CYS 387.A N GLN 384.A O no hydrogen 3.474 N/A CYS 387.A SG ILE 380.A O no hydrogen 3.337 N/A CYS 387.A SG GLN 384.A O no hydrogen 3.144 N/A TYR 390.A OH ASP 381.A OD2 no hydrogen 3.190 N/A ASP 391.A N ASP 391.A OD1 no hydrogen 2.522 N/A LYS 394.A NZ LEU 392.A O no hydrogen 3.398 N/A SER 395.A N ASN 397.A OD1 no hydrogen 3.267 N/A THR 399.A N ASP 402.A OD1 no hydrogen 2.586 N/A THR 399.A N ASP 402.A OD2 no hydrogen 3.099 N/A GLU 400.A N THR 399.A OG1 no hydrogen 2.784 N/A LYS 403.A NZ GLU 400.A O no hydrogen 3.039 N/A HIS 404.A N ASP 401.A O no hydrogen 3.262 N/A ASN 405.A N ASP 402.A O no hydrogen 3.286 N/A ALA 407.A N LYS 403.A O no hydrogen 2.904 N/A LYS 408.A N HIS 404.A O no hydrogen 2.926 N/A TYR 409.A N ASN 405.A O no hydrogen 2.886 N/A TYR 409.A OH ASN 389.A O no hydrogen 2.483 N/A ALA 410.A N ASN 406.A O no hydrogen 2.874 N/A VAL 411.A N ALA 407.A O no hydrogen 2.934 N/A SER 412.A N LYS 408.A O no hydrogen 2.891 N/A SER 412.A OG LYS 408.A O no hydrogen 3.472 N/A SER 412.A OG TYR 409.A O no hydrogen 2.966 N/A ALA 414.A N VAL 411.A O no hydrogen 3.201 N/A ILE 417.A N MET 413.A O no hydrogen 2.953 N/A GLY 418.A N ALA 414.A O no hydrogen 3.076 N/A ALA 419.A N ALA 414.A O no hydrogen 2.567 N/A VAL 421.A N ALA 419.A O no hydrogen 2.696 N/A TYR 422.A OH THR 327.A OG1 no hydrogen 3.205 N/A GLU 426.A N GLU 426.A OE1 no hydrogen 2.723 N/A VAL 429.A N PRO 425.A O no hydrogen 2.891 N/A GLU 430.A N GLU 426.A O no hydrogen 2.894 N/A THR 438.A OG1 MET 435.A O no hydrogen 2.367 N/A VAL 439.A N MET 435.A O no hydrogen 2.929 N/A PHE 440.A N VAL 436.A O no hydrogen 2.928 N/A ALA 441.A N MET 437.A O no hydrogen 2.857 N/A CYS 442.A N THR 438.A O no hydrogen 2.901 N/A CYS 442.A SG ARG 420.A O no hydrogen 3.277 N/A CYS 442.A SG THR 438.A O no hydrogen 3.319 N/A LEU 443.A N VAL 439.A O no hydrogen 2.920 N/A MET 444.A N PHE 440.A O no hydrogen 2.903 N/A GLY 445.A N ALA 441.A O no hydrogen 3.262 N/A GLY 447.A N LEU 443.A O no hydrogen 2.933 N/A MET 448.A N MET 444.A O no hydrogen 3.132 N/A