Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7xc0_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 4.A N LEU 250.A O no hydrogen 2.731 N/A ALA 6.A N GLY 248.A O no hydrogen 2.914 N/A GLU 7.A N GLU 7.A OE1 no hydrogen 2.586 N/A ASP 8.A N PRO 5.A O no hydrogen 2.796 N/A PHE 9.A N ALA 6.A O no hydrogen 3.228 N/A HIS 12.A N ASP 8.A O no hydrogen 3.215 N/A VAL 13.A N PHE 9.A O no hydrogen 2.996 N/A ARG 14.A N ALA 10.A O no hydrogen 3.238 N/A LYS 15.A N ASP 11.A O no hydrogen 2.959 N/A ASN 16.A N HIS 12.A O no hydrogen 3.125 N/A ASN 16.A ND2 GLU 27.A OE2 no hydrogen 2.971 N/A GLU 17.A N VAL 13.A O no hydrogen 3.028 N/A GLU 17.A N ARG 14.A O no hydrogen 3.329 N/A SER 20.A OG ASP 19.A O no hydrogen 2.809 N/A SER 20.A OG SER 20.A O no hydrogen 2.349 N/A ASN 21.A N GLU 17.A O no hydrogen 2.818 N/A ALA 22.A N ARG 18.A O no hydrogen 2.862 N/A PHE 24.A N ASN 16.A O no hydrogen 3.196 N/A ALA 25.A N ASN 21.A O no hydrogen 2.865 N/A ASP 26.A N ALA 22.A O no hydrogen 3.237 N/A GLU 27.A N GLY 23.A O no hydrogen 3.060 N/A TYR 28.A N PHE 24.A O no hydrogen 2.860 N/A TYR 28.A OH VAL 267.A O no hydrogen 2.638 N/A GLN 29.A N ALA 25.A O no hydrogen 2.833 N/A GLN 30.A N ASP 26.A O no hydrogen 2.993 N/A LEU 31.A N GLU 27.A O no hydrogen 2.895 N/A SER 32.A N TYR 28.A O no hydrogen 2.934 N/A SER 32.A OG TYR 28.A O no hydrogen 2.805 N/A LEU 33.A N GLN 30.A O no hydrogen 3.256 N/A VAL 34.A N LEU 31.A O no hydrogen 3.158 N/A HIS 36.A NE2 SER 32.A O no hydrogen 2.600 N/A GLN 38.A NE2 GLY 35.A O no hydrogen 3.134 N/A GLN 38.A NE2 GLU 261.A O no hydrogen 2.883 N/A SER 39.A OG ASP 61.A OD2 no hydrogen 2.532 N/A GLN 40.A NE2 LEU 58.A O no hydrogen 2.893 N/A MET 41.A N ASP 61.A OD2 no hydrogen 2.897 N/A VAL 42.A N ASP 61.A OD1 no hydrogen 2.984 N/A SER 44.A N GLN 40.A O no hydrogen 3.019 N/A SER 44.A OG GLN 40.A O no hydrogen 2.866 N/A ALA 45.A N VAL 42.A O no hydrogen 3.141 N/A GLU 47.A N GLU 47.A OE1 no hydrogen 3.090 N/A ASN 48.A N ALA 45.A O no hydrogen 2.921 N/A ASN 48.A ND2 VAL 42.A O no hydrogen 2.947 N/A ASN 49.A N SER 46.A O no hydrogen 3.288 N/A LYS 51.A N ASN 48.A O no hydrogen 3.141 N/A LYS 51.A NZ ASN 48.A OD1 no hydrogen 2.884 N/A ASN 52.A ND2 ALA 43.A O no hydrogen 3.076 N/A ARG 53.A N GLN 97.A OE1 no hydrogen 2.877 N/A ARG 53.A NE GLY 98.A O no hydrogen 2.968 N/A ARG 53.A NH2 GLY 98.A O no hydrogen 3.102 N/A ARG 53.A NH2 PRO 99.A O no hydrogen 2.772 N/A TYR 54.A OH SER 225.A OG no hydrogen 2.707 N/A VAL 57.A N TYR 54.A O no hydrogen 3.129 N/A ASP 61.A N SER 39.A O no hydrogen 2.905 N/A TRP 62.A NE1 GLU 261.A O no hydrogen 2.919 N/A SER 63.A OG SER 262.A O no hydrogen 2.542 N/A ARG 64.A NH1 ASP 77.A O no hydrogen 3.067 N/A ARG 64.A NH2 ASP 77.A OD2 no hydrogen 2.753 N/A VAL 65.A N ALA 81.A O no hydrogen 3.054 N/A LEU 67.A N ASP 77.A O no hydrogen 2.823 N/A LYS 68.A N GLU 113.A OE1 no hydrogen 2.895 N/A ILE 70.A N SER 76.A OG no hydrogen 2.920 N/A SER 76.A N GLU 73.A O no hydrogen 3.142 N/A SER 76.A OG ILE 70.A O no hydrogen 3.425 N/A SER 76.A OG GLU 73.A O no hydrogen 2.615 N/A TYR 78.A N GLY 75.A O no hydrogen 3.091 N/A TYR 78.A OH ASN 52.A OD1 no hydrogen 2.512 N/A ASN 80.A ND2 ASN 52.A OD1 no hydrogen 3.019 N/A ASN 80.A ND2 VAL 57.A O no hydrogen 3.092 N/A SER 82.A N ALA 95.A O no hydrogen 2.818 N/A PHE 83.A N SER 63.A O no hydrogen 2.796 N/A MET 84.A N PHE 93.A O no hydrogen 2.832 N/A GLY 86.A N SER 89.A O no hydrogen 2.787 N/A LEU 87.A N GLU 92.A OE2 no hydrogen 2.908 N/A TRP 88.A N GLU 92.A OE1 no hydrogen 2.839 N/A GLN 91.A N SER 89.A OG no hydrogen 2.991 N/A PHE 93.A N MET 84.A O no hydrogen 3.154 N/A ILE 94.A N PRO 220.A O no hydrogen 2.998 N/A ALA 95.A N SER 82.A O no hydrogen 2.941 N/A THR 96.A N VAL 222.A O no hydrogen 3.055 N/A THR 96.A OG1 ASN 80.A O no hydrogen 2.588 N/A GLN 97.A N ASN 80.A O no hydrogen 3.357 N/A GLN 97.A NE2 LYS 51.A O no hydrogen 2.844 N/A GLY 98.A N SER 225.A O no hydrogen 2.925 N/A LEU 100.A N THR 103.A OG1 no hydrogen 2.985 N/A GLN 102.A N GLN 102.A OE1 no hydrogen 2.641 N/A GLN 102.A NE2 ALA 50.A O no hydrogen 2.735 N/A THR 103.A N LEU 100.A O no hydrogen 2.979 N/A THR 103.A OG1 LEU 100.A O no hydrogen 3.489 N/A PHE 107.A N THR 103.A O no hydrogen 2.862 N/A TRP 108.A N VAL 104.A O no hydrogen 3.132 N/A TRP 108.A NE1 TYR 136.A O no hydrogen 2.917 N/A ARG 109.A N GLY 105.A O no hydrogen 3.008 N/A ARG 109.A NH1 LYS 68.A O no hydrogen 2.726 N/A ARG 109.A NH1 GLU 113.A OE2 no hydrogen 2.959 N/A ARG 109.A NH2 SER 76.A O no hydrogen 2.770 N/A LEU 110.A N ASP 106.A O no hydrogen 2.837 N/A VAL 111.A N PHE 107.A O no hydrogen 3.001 N/A TRP 112.A N TRP 108.A O no hydrogen 2.881 N/A GLU 113.A N ARG 109.A O no hydrogen 2.855 N/A GLN 114.A N LEU 110.A O no hydrogen 3.041 N/A GLN 115.A N TRP 112.A O no hydrogen 3.006 N/A GLN 115.A NE2 TRP 112.A O no hydrogen 2.812 N/A SER 116.A N VAL 111.A O no hydrogen 3.268 N/A SER 116.A OG.A PRO 219.A O no hydrogen 2.872 N/A SER 116.A OG.B PRO 219.A O no hydrogen 2.661 N/A LEU 119.A N ARG 181.A O no hydrogen 2.888 N/A VAL 120.A N ILE 221.A O no hydrogen 2.867 N/A MET 121.A N PHE 183.A O no hydrogen 2.829 N/A LEU 122.A N HIS 223.A O no hydrogen 2.961 N/A THR 123.A OG1 ASN 124.A O no hydrogen 2.912 N/A THR 123.A OG1 GLU 127.A OE1 no hydrogen 3.045 N/A ASN 124.A N GLU 127.A OE1 no hydrogen 3.341 N/A ASN 124.A ND2 GLN 186.A O no hydrogen 3.146 N/A GLU 127.A N ARG 130.A O no hydrogen 2.827 N/A ARG 130.A N GLU 127.A O no hydrogen 2.926 N/A ARG 130.A NE ALA 128.A O no hydrogen 2.983 N/A LYS 132.A N CYS 125.A O no hydrogen 2.809 N/A LYS 132.A NZ ASP 190.A OD2 no hydrogen 2.792 N/A CYS 133.A N CYS 125.A O no hydrogen 3.131 N/A CYS 133.A SG GLU 134.A O no hydrogen 3.386 N/A GLU 134.A N PRO 99.A O no hydrogen 3.019 N/A TYR 136.A OH HIS 223.A NE2 no hydrogen 2.708 N/A GLN 142.A N LEU 139.A O no hydrogen 3.317 N/A CYS 144.A N VAL 151.A O no hydrogen 3.053 N/A CYS 144.A SG HIS 146.A NE2 no hydrogen 3.603 N/A HIS 146.A N LEU 149.A O no hydrogen 2.875 N/A LEU 149.A N HIS 146.A O no hydrogen 2.822 N/A ARG 150.A N LEU 170.A O no hydrogen 2.927 N/A VAL 151.A N CYS 144.A O no hydrogen 2.797 N/A THR 152.A N LEU 168.A O no hydrogen 2.903 N/A VAL 154.A N GLU 166.A O no hydrogen 2.731 N/A GLY 155.A N GLU 166.A O no hydrogen 3.261 N/A GLU 157.A N VAL 164.A O no hydrogen 2.894 N/A MET 159.A N TRP 162.A O no hydrogen 2.856 N/A THR 163.A N HIS 184.A O no hydrogen 2.874 N/A THR 163.A OG1 GLN 186.A OE1 no hydrogen 2.773 N/A VAL 164.A N GLU 157.A O no hydrogen 2.984 N/A ARG 165.A N GLN 182.A O no hydrogen 2.874 N/A ARG 165.A NE GLU 156.A OE2 no hydrogen 2.963 N/A ARG 165.A NH1 GLN 182.A OE1 no hydrogen 2.726 N/A ARG 165.A NH1 HIS 184.A ND1 no hydrogen 3.086 N/A GLU 166.A N GLY 155.A O no hydrogen 2.798 N/A LEU 167.A N VAL 180.A O no hydrogen 2.725 N/A LEU 168.A N THR 152.A O no hydrogen 2.834 N/A LEU 169.A N LEU 178.A O no hydrogen 2.780 N/A LEU 170.A N ARG 150.A O no hydrogen 2.884 N/A GLN 171.A N LYS 176.A O no hydrogen 2.994 N/A VAL 172.A N HIS 148.A O no hydrogen 2.912 N/A GLU 174.A N GLN 171.A O no hydrogen 3.256 N/A GLU 174.A N GLN 171.A OE1 no hydrogen 2.989 N/A LYS 176.A NZ GLN 115.A OE1 no hydrogen 2.877 N/A LYS 176.A NZ THR 177.A O no hydrogen 3.224 N/A LEU 178.A N LEU 169.A O no hydrogen 2.653 N/A VAL 180.A N LEU 167.A O no hydrogen 2.860 N/A ARG 181.A N HIS 117.A O no hydrogen 2.910 N/A GLN 182.A N ARG 165.A O no hydrogen 2.755 N/A GLN 182.A NE2 TYR 136.A OH no hydrogen 2.959 N/A PHE 183.A N LEU 119.A O no hydrogen 2.768 N/A HIS 184.A N THR 163.A O no hydrogen 2.831 N/A HIS 184.A NE2 THR 123.A O no hydrogen 2.702 N/A TYR 185.A N MET 121.A O no hydrogen 2.767 N/A GLN 186.A N ASN 161.A O no hydrogen 2.906 N/A TRP 188.A NE1 GLY 192.A O no hydrogen 2.874 N/A ASP 190.A N GLU 127.A OE2 no hydrogen 3.037 N/A HIS 191.A ND1 GLN 268.A OE1 no hydrogen 2.623 N/A GLY 192.A N PRO 189.A O no hydrogen 2.959 N/A ASP 198.A N SER 196.A OG no hydrogen 3.160 N/A THR 199.A OG1 TYR 185.A OH no hydrogen 3.164 N/A THR 199.A OG1 SER 196.A O no hydrogen 3.213 N/A LEU 201.A N PRO 197.A O no hydrogen 2.936 N/A ALA 202.A N ASP 198.A O no hydrogen 3.020 N/A PHE 203.A N THR 199.A O no hydrogen 3.107 N/A TRP 204.A N LEU 200.A O no hydrogen 2.807 N/A TRP 204.A NE1 ASP 238.A OD1 no hydrogen 2.757 N/A ARG 205.A N LEU 201.A O no hydrogen 2.821 N/A ARG 205.A NH2 GLN 286.A OE1 no hydrogen 2.492 N/A MET 206.A N ALA 202.A O no hydrogen 3.210 N/A LEU 207.A N PHE 203.A O no hydrogen 2.973 N/A ARG 208.A N TRP 204.A O no hydrogen 2.758 N/A ARG 208.A NE ASP 238.A OD1 no hydrogen 3.004 N/A ARG 208.A NH1 ASP 212.A OD1 no hydrogen 3.143 N/A ARG 208.A NH2 ASP 238.A OD1 no hydrogen 3.422 N/A ARG 208.A NH2 ASP 238.A OD2 no hydrogen 2.902 N/A GLN 209.A N ARG 205.A O no hydrogen 2.935 N/A TRP 210.A N MET 206.A O no hydrogen 3.117 N/A TRP 210.A NE1 THR 118.A OG1 no hydrogen 2.869 N/A LEU 211.A N LEU 207.A O no hydrogen 2.889 N/A ASP 212.A N ARG 208.A O no hydrogen 2.844 N/A GLN 213.A N TRP 210.A O no hydrogen 2.974 N/A THR 214.A N LEU 211.A O no hydrogen 3.197 N/A THR 214.A OG1 TRP 210.A O no hydrogen 3.100 N/A GLU 216.A N GLU 216.A OE1 no hydrogen 3.191 N/A GLY 218.A N GLN 115.A O no hydrogen 2.952 N/A ILE 221.A N THR 118.A O no hydrogen 3.025 N/A VAL 222.A N ILE 94.A O no hydrogen 2.761 N/A HIS 223.A N VAL 120.A O no hydrogen 2.844 N/A HIS 223.A ND1 SER 224.A O no hydrogen 3.185 N/A HIS 223.A NE2 TYR 136.A OH no hydrogen 2.708 N/A SER 224.A OG THR 231.A OG1 no hydrogen 2.917 N/A SER 225.A OG TYR 54.A OH no hydrogen 2.707 N/A SER 225.A OG LYS 132.A O no hydrogen 2.708 N/A GLY 227.A N SER 224.A OG no hydrogen 3.113 N/A ARG 230.A NH1 GLU 127.A OE1 no hydrogen 2.770 N/A ARG 230.A NH1 TRP 188.A O no hydrogen 2.836 N/A THR 231.A OG1 SER 224.A OG no hydrogen 2.917 N/A GLY 232.A N VAL 228.A O no hydrogen 2.956 N/A THR 233.A N GLY 229.A O no hydrogen 3.027 N/A THR 233.A OG1 GLY 229.A O no hydrogen 2.815 N/A LEU 234.A N ARG 230.A O no hydrogen 3.072 N/A ILE 235.A N THR 231.A O no hydrogen 3.038 N/A ALA 236.A N GLY 232.A O no hydrogen 2.982 N/A LEU 237.A N THR 233.A O no hydrogen 2.992 N/A ASP 238.A N LEU 234.A O no hydrogen 3.013 N/A VAL 239.A N ILE 235.A O no hydrogen 2.946 N/A LEU 240.A N ALA 236.A O no hydrogen 2.926 N/A LEU 241.A N LEU 237.A O no hydrogen 3.014 N/A ARG 242.A N ASP 238.A O no hydrogen 3.127 N/A ARG 242.A NE ASP 238.A OD2 no hydrogen 2.963 N/A ARG 242.A NH1 GLU 92.A OE2 no hydrogen 3.190 N/A ARG 242.A NH2 GLU 92.A OE2 no hydrogen 2.497 N/A ARG 242.A NH2 ASP 238.A OD2 no hydrogen 2.970 N/A GLN 243.A N VAL 239.A O no hydrogen 2.762 N/A LEU 244.A N LEU 240.A O no hydrogen 2.768 N/A GLN 245.A N LEU 241.A O no hydrogen 3.140 N/A SER 246.A N ARG 242.A O no hydrogen 2.832 N/A GLU 247.A N GLN 243.A O no hydrogen 2.788 N/A GLY 248.A N LEU 244.A O no hydrogen 2.961 N/A LEU 250.A N ILE 4.A O no hydrogen 2.832 N/A GLY 251.A N GLN 243.A OE1 no hydrogen 3.046 N/A PHE 255.A N GLY 251.A O no hydrogen 2.959 N/A VAL 256.A N PRO 252.A O no hydrogen 2.963 N/A ARG 257.A N PHE 253.A O no hydrogen 2.997 N/A ARG 257.A NH1 GLU 261.A OE1 no hydrogen 2.884 N/A LYS 258.A N SER 254.A O no hydrogen 3.073 N/A LYS 258.A NZ SER 254.A O no hydrogen 2.852 N/A MET 259.A N PHE 255.A O no hydrogen 2.887 N/A ARG 260.A N VAL 256.A O no hydrogen 2.848 N/A ARG 260.A NE MET 266.A O no hydrogen 2.709 N/A ARG 260.A NH2 MET 266.A O no hydrogen 3.106 N/A ARG 260.A NH2 VAL 267.A O no hydrogen 2.850 N/A GLU 261.A N ARG 257.A O no hydrogen 3.088 N/A GLU 261.A N LYS 258.A O no hydrogen 3.190 N/A SER 262.A N MET 259.A O no hydrogen 2.978 N/A ARG 263.A N MET 259.A O no hydrogen 2.985 N/A ARG 263.A NE GLY 227.A O no hydrogen 2.910 N/A ARG 263.A NH1 ASN 80.A OD1 no hydrogen 3.021 N/A ARG 263.A NH1 SER 82.A OG no hydrogen 3.035 N/A ARG 263.A NH2 ASN 80.A OD1 no hydrogen 2.934 N/A ARG 263.A NH2 ALA 226.A O no hydrogen 3.002 N/A VAL 267.A N VAL 228.A O no hydrogen 3.035 N/A GLN 268.A N GLN 272.A OE1 no hydrogen 2.879 N/A THR 269.A N GLN 272.A OE1 no hydrogen 3.250 N/A GLN 272.A N THR 269.A OG1 no hydrogen 2.967 N/A GLN 272.A NE2 GLY 192.A O no hydrogen 3.096 N/A TYR 273.A N THR 269.A O no hydrogen 3.168 N/A TYR 273.A OH GLU 27.A OE1 no hydrogen 2.716 N/A VAL 274.A N GLU 270.A O no hydrogen 2.970 N/A PHE 275.A N ALA 271.A O no hydrogen 2.789 N/A LEU 276.A N GLN 272.A O no hydrogen 2.880 N/A HIS 277.A N TYR 273.A O no hydrogen 3.442 N/A HIS 277.A ND1 TYR 273.A O no hydrogen 2.881 N/A GLN 278.A N VAL 274.A O no hydrogen 3.013 N/A GLN 278.A NE2 GLU 17.A OE2 no hydrogen 3.414 N/A CYS 279.A N PHE 275.A O no hydrogen 2.931 N/A CYS 279.A SG PHE 275.A O no hydrogen 3.590 N/A ILE 280.A N LEU 276.A O no hydrogen 3.278 N/A LEU 281.A N HIS 277.A O no hydrogen 2.936 N/A ARG 282.A N GLN 278.A O no hydrogen 2.951 N/A PHE 283.A N CYS 279.A O no hydrogen 2.868 N/A LEU 284.A N ILE 280.A O no hydrogen 3.048 N/A GLN 285.A N LEU 281.A O no hydrogen 2.881 N/A GLN 286.A N ARG 282.A O no hydrogen 2.679 N/A SER 287.A N LEU 284.A O no hydrogen 3.008 N/A SER 287.A OG PHE 283.A O no hydrogen 2.548 N/A