Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 7xyk_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 6.A N GLU 3.A O no hydrogen 3.218 N/A GLN 7.A N GLY 4.A O no hydrogen 2.894 N/A GLN 7.A NE2 MET 2.A O no hydrogen 2.797 N/A TYR 8.A N GLU 5.A O no hydrogen 3.000 N/A TYR 8.A OH VAL 195.A O no hydrogen 2.604 N/A LEU 9.A N GLU 5.A O no hydrogen 3.047 N/A ASN 10.A N HIS 6.A O no hydrogen 2.767 N/A ASN 10.A ND2 ALA 1.A O no hydrogen 3.083 N/A LEU 11.A N GLN 7.A O no hydrogen 3.244 N/A VAL 12.A N TYR 8.A O no hydrogen 2.967 N/A ARG 13.A N LEU 9.A O no hydrogen 2.987 N/A GLU 14.A N ASN 10.A O no hydrogen 2.835 N/A ILE 15.A N LEU 11.A O no hydrogen 2.950 N/A LEU 16.A N VAL 12.A O no hydrogen 2.984 N/A GLU 17.A N ARG 13.A O no hydrogen 2.849 N/A ARG 18.A N GLU 14.A O no hydrogen 2.783 N/A GLY 19.A N ILE 15.A O no hydrogen 2.780 N/A VAL 20.A N SER 32.A O no hydrogen 2.946 N/A LYS 22.A N THR 30.A O no hydrogen 2.878 N/A LYS 22.A NZ ASP 230.A OD2 no hydrogen 2.666 N/A THR 26.A N ASP 24.A OD2 no hydrogen 2.933 N/A THR 26.A OG1 ASP 24.A OD1 no hydrogen 3.267 N/A THR 26.A OG1 ASP 24.A OD2 no hydrogen 2.669 N/A THR 26.A OG1 THR 28.A OG1 no hydrogen 3.029 N/A GLY 27.A N ASP 24.A O no hydrogen 2.961 N/A THR 28.A N THR 26.A OG1 no hydrogen 3.250 N/A THR 28.A OG1 THR 26.A OG1 no hydrogen 3.029 N/A GLY 29.A N ASP 24.A OD1 no hydrogen 2.795 N/A THR 30.A N LYS 22.A O no hydrogen 2.801 N/A THR 30.A OG1 LYS 22.A O no hydrogen 3.090 N/A LEU 31.A N ILE 233.A O no hydrogen 2.931 N/A SER 32.A N VAL 20.A O no hydrogen 3.015 N/A SER 32.A OG ASP 230.A OD1 no hydrogen 2.938 N/A ILE 33.A N ALA 231.A O no hydrogen 2.996 N/A GLY 35.A N GLY 229.A O no hydrogen 2.960 N/A GLN 37.A NE2 GLN 187.A OE1 no hydrogen 3.235 N/A GLN 37.A NE2 THR 227.A OG1 no hydrogen 3.089 N/A MET 38.A N LEU 226.A O no hydrogen 2.874 N/A ARG 39.A N GLN 7.A OE1 no hydrogen 2.865 N/A ARG 39.A NE GLU 223.A OE2 no hydrogen 2.850 N/A ARG 39.A NH1 GLU 223.A OE1 no hydrogen 3.096 N/A ARG 39.A NH1 GLU 223.A OE2 no hydrogen 3.513 N/A ARG 39.A NH2 GLN 37.A OE1 no hydrogen 3.110 N/A PHE 40.A N PHE 224.A O no hydrogen 2.830 N/A LEU 42.A N GLY 222.A O no hydrogen 2.809 N/A ARG 43.A N SER 41.A OG no hydrogen 3.215 N/A THR 46.A N ARG 43.A O no hydrogen 3.040 N/A THR 46.A OG1 ARG 43.A O no hydrogen 3.077 N/A ILE 47.A N PRO 253.A O no hydrogen 3.054 N/A VAL 49.A N ILE 47.A O no hydrogen 2.867 N/A THR 51.A N GLU 5.A OE1 no hydrogen 2.967 N/A THR 51.A OG1 GLU 5.A OE1 no hydrogen 2.777 N/A THR 51.A OG1 ARG 250.A O no hydrogen 3.351 N/A THR 52.A N GLU 5.A OE2 no hydrogen 2.881 N/A THR 52.A OG1 GLU 5.A OE2 no hydrogen 2.661 N/A ILE 55.A N TYR 277.A OH no hydrogen 2.902 N/A TRP 57.A N ILE 55.A O no hydrogen 2.858 N/A ARG 58.A NH1 LYS 80.A O no hydrogen 2.936 N/A ARG 58.A NH2 LYS 80.A O no hydrogen 2.894 N/A VAL 60.A N PHE 56.A O no hydrogen 2.908 N/A VAL 61.A N TRP 57.A O no hydrogen 2.929 N/A GLU 62.A N ARG 58.A O no hydrogen 2.985 N/A GLU 63.A N GLY 59.A O no hydrogen 2.865 N/A LEU 64.A N VAL 60.A O no hydrogen 2.988 N/A LEU 65.A N VAL 61.A O no hydrogen 2.931 N/A TRP 66.A N GLU 62.A O no hydrogen 2.998 N/A TRP 66.A NE1 ASP 73.A O no hydrogen 3.043 N/A PHE 67.A N GLU 63.A O no hydrogen 2.917 N/A ILE 68.A N LEU 64.A O no hydrogen 2.811 N/A ARG 69.A N LEU 65.A O no hydrogen 2.991 N/A ARG 69.A NE ASN 71.A OD1 no hydrogen 3.025 N/A GLY 70.A N PHE 67.A O no hydrogen 2.804 N/A ASN 71.A N TRP 66.A O no hydrogen 2.970 N/A THR 72.A OG1 TYR 122.A OH no hydrogen 2.780 N/A ALA 74.A N GLY 105.A O no hydrogen 2.825 N/A LYS 75.A N ASP 73.A OD1 no hydrogen 2.885 N/A LYS 75.A NZ ASP 73.A OD1 no hydrogen 2.782 N/A LYS 75.A NZ ASP 73.A OD2 no hydrogen 3.465 N/A LYS 75.A NZ GLU 104.A O no hydrogen 2.748 N/A GLU 76.A N ASP 73.A O no hydrogen 3.133 N/A ALA 78.A N ALA 74.A O no hydrogen 2.933 N/A LYS 79.A N LYS 75.A O no hydrogen 2.926 N/A LYS 79.A NZ GLU 76.A OE1 no hydrogen 2.884 N/A LYS 80.A N LEU 77.A O no hydrogen 2.925 N/A LYS 81.A N ALA 78.A O no hydrogen 2.884 N/A ILE 82.A N LEU 77.A O no hydrogen 2.920 N/A TRP 85.A NE1 GLU 63.A OE2 no hydrogen 2.791 N/A ASN 86.A N HIS 83.A O no hydrogen 3.059 N/A ASN 86.A ND2 HIS 83.A ND1 no hydrogen 3.074 N/A GLY 89.A N TRP 85.A O no hydrogen 3.268 N/A GLY 89.A N ASN 86.A O no hydrogen 3.091 N/A SER 90.A N ALA 87.A O no hydrogen 3.205 N/A SER 90.A OG ALA 87.A O no hydrogen 3.101 N/A ARG 91.A N GLU 104.A OE2 no hydrogen 2.818 N/A ARG 91.A NE ASP 95.A OD1 no hydrogen 2.966 N/A ARG 91.A NE ASP 95.A OD2 no hydrogen 3.315 N/A ARG 91.A NH1 ASP 95.A OD1 no hydrogen 3.079 N/A ARG 91.A NH1 ARG 102.A O no hydrogen 2.868 N/A ARG 91.A NH2 ARG 102.A O no hydrogen 2.851 N/A PHE 93.A N SER 90.A OG no hydrogen 3.115 N/A LEU 94.A N SER 90.A O no hydrogen 2.821 N/A ASP 95.A N ARG 91.A O no hydrogen 2.865 N/A SER 96.A N GLU 92.A O no hydrogen 2.974 N/A SER 96.A OG PHE 93.A O no hydrogen 2.622 N/A ARG 97.A N PHE 93.A O no hydrogen 3.196 N/A ARG 97.A N LEU 94.A O no hydrogen 3.026 N/A ARG 97.A NE MET 166.A O no hydrogen 3.021 N/A ARG 97.A NH2 MET 166.A O no hydrogen 2.787 N/A GLY 98.A N ASP 95.A O no hydrogen 2.896 N/A LEU 99.A N LEU 94.A O no hydrogen 2.900 N/A ARG 102.A N LEU 99.A O no hydrogen 3.199 N/A ARG 102.A NH1 ASP 106.A O no hydrogen 3.117 N/A ARG 102.A NH1 LEU 165.A O no hydrogen 3.114 N/A ARG 102.A NH2 LEU 165.A O no hydrogen 2.756 N/A GLY 105.A N GLY 89.A O no hydrogen 2.730 N/A ASP 106.A N ALA 103.A O no hydrogen 3.009 N/A LEU 107.A N THR 72.A O no hydrogen 3.139 N/A GLY 108.A N ASP 106.A OD1 no hydrogen 3.127 N/A VAL 110.A N GLY 108.A O no hydrogen 2.783 N/A PHE 113.A N VAL 110.A O no hydrogen 2.909 N/A GLN 114.A NE2 PRO 109.A O no hydrogen 2.897 N/A GLN 114.A NE2 ASP 162.A OD2 no hydrogen 2.924 N/A TRP 115.A N TYR 111.A O no hydrogen 3.055 N/A ARG 116.A N GLY 112.A O no hydrogen 3.020 N/A ARG 116.A NE ASP 135.A OD1 no hydrogen 2.766 N/A ARG 116.A NE ASP 135.A OD2 no hydrogen 3.424 N/A ARG 116.A NH1 ILE 68.A O no hydrogen 2.810 N/A ARG 116.A NH1 GLU 265.A OE1 no hydrogen 2.979 N/A ARG 116.A NH2 ASP 135.A OD1 no hydrogen 3.376 N/A ARG 116.A NH2 ASP 135.A OD2 no hydrogen 2.927 N/A ARG 116.A NH2 GLU 265.A OE1 no hydrogen 3.143 N/A HIS 117.A N PHE 113.A O no hydrogen 2.796 N/A HIS 117.A ND1 LYS 132.A O no hydrogen 2.868 N/A PHE 118.A N ILE 134.A O no hydrogen 3.037 N/A ALA 120.A N HIS 117.A O no hydrogen 2.965 N/A TYR 122.A OH THR 72.A OG1 no hydrogen 2.780 N/A TYR 122.A OH ASP 106.A OD1 no hydrogen 2.566 N/A ASP 123.A N TYR 129.A OH no hydrogen 2.801 N/A THR 124.A N SER 127.A OG no hydrogen 3.010 N/A THR 124.A OG1 SER 126.A OG no hydrogen 3.124 N/A THR 124.A OG1 SER 127.A OG no hydrogen 3.276 N/A CYS 125.A N ASP 106.A OD2 no hydrogen 2.867 N/A SER 126.A N THR 124.A OG1 no hydrogen 3.125 N/A SER 126.A OG THR 124.A OG1 no hydrogen 3.124 N/A SER 127.A N THR 124.A O no hydrogen 3.290 N/A SER 127.A OG THR 124.A O no hydrogen 3.264 N/A SER 127.A OG THR 124.A OG1 no hydrogen 3.276 N/A TYR 129.A OH THR 124.A O no hydrogen 2.684 N/A THR 130.A N ASP 128.A OD1 no hydrogen 2.941 N/A THR 130.A OG1 ASP 128.A OD1 no hydrogen 2.613 N/A LYS 132.A N TYR 129.A O no hydrogen 2.909 N/A ILE 134.A N PHE 118.A O no hydrogen 2.871 N/A GLN 136.A NE2 GLN 114.A O no hydrogen 2.825 N/A GLN 136.A NE2 THR 156.A O no hydrogen 2.884 N/A LEU 137.A N TRP 115.A O no hydrogen 3.307 N/A ALA 138.A N ASP 135.A OD1 no hydrogen 3.001 N/A ASN 139.A N ASP 135.A O no hydrogen 3.023 N/A ILE 140.A N GLN 136.A O no hydrogen 2.929 N/A LEU 141.A N LEU 137.A O no hydrogen 3.017 N/A LYS 142.A N ALA 138.A O no hydrogen 3.027 N/A THR 143.A N ASN 139.A O no hydrogen 2.909 N/A THR 143.A OG1 ASN 139.A O no hydrogen 2.880 N/A THR 143.A OG1 ASN 139.A OD1.B no hydrogen 3.402 N/A LEU 144.A N ILE 140.A O no hydrogen 2.854 N/A ARG 145.A N LEU 141.A O no hydrogen 3.299 N/A ARG 145.A NH2 MET 216.A O no hydrogen 3.325 N/A GLU 146.A N LYS 142.A O no hydrogen 3.019 N/A ASN 147.A N THR 143.A O no hydrogen 2.717 N/A ASP 150.A N ASN 147.A O no hydrogen 2.994 N/A ARG 152.A N ASP 150.A OD2 no hydrogen 2.829 N/A ILE 154.A N ARG 152.A O no hydrogen 2.820 N/A MET 155.A N ALA 175.A O no hydrogen 2.838 N/A THR 156.A N GLN 136.A OE1 no hydrogen 2.942 N/A THR 156.A OG1 MET 173.A O no hydrogen 3.153 N/A THR 156.A OG1 THR 174.A OG1 no hydrogen 2.874 N/A ALA 157.A N MET 173.A O no hydrogen 2.838 N/A TRP 158.A N THR 156.A OG1 no hydrogen 2.978 N/A ASN 159.A ND2 GLN 114.A OE1 no hydrogen 3.248 N/A MET 161.A N ASN 159.A OD1 no hydrogen 3.046 N/A ASP 162.A N ASN 159.A O no hydrogen 2.892 N/A LEU 165.A N ASP 162.A O no hydrogen 2.900 N/A MET 166.A N LEU 163.A O no hydrogen 3.003 N/A ALA 167.A N LEU 107.A O no hydrogen 2.894 N/A CYS 171.A N TYR 111.A OH no hydrogen 2.744 N/A HIS 172.A ND1 TYR 206.A OH no hydrogen 2.713 N/A MET 173.A N TYR 189.A O no hydrogen 3.029 N/A THR 174.A N TYR 189.A O no hydrogen 3.302 N/A THR 174.A OG1 THR 156.A OG1 no hydrogen 2.874 N/A ALA 175.A N MET 155.A O no hydrogen 2.843 N/A GLN 176.A N GLN 187.A O no hydrogen 2.831 N/A PHE 177.A N MET 153.A O no hydrogen 2.951 N/A TYR 178.A N SER 185.A O no hydrogen 3.044 N/A ALA 180.A N GLU 183.A O no hydrogen 3.024 N/A GLU 183.A N ALA 180.A O no hydrogen 2.943 N/A LEU 184.A N LYS 220.A O no hydrogen 2.769 N/A SER 185.A N TYR 178.A O no hydrogen 2.829 N/A CYS 186.A N GLU 223.A O no hydrogen 2.980 N/A GLN 187.A N GLN 176.A O no hydrogen 2.845 N/A LEU 188.A N ILE 225.A O no hydrogen 2.844 N/A TYR 189.A N THR 174.A O no hydrogen 2.737 N/A GLN 190.A N THR 227.A O no hydrogen 2.923 N/A GLN 190.A NE2 SER 192.A O no hydrogen 3.151 N/A GLN 190.A NE2 ASN 202.A OD1 no hydrogen 2.950 N/A ARG 191.A N CYS 171.A O no hydrogen 2.964 N/A ARG 191.A NE PRO 170.A O no hydrogen 2.738 N/A ARG 191.A NH2 PRO 169.A O no hydrogen 3.139 N/A GLY 193.A N ASP 230.A O no hydrogen 2.968 N/A VAL 195.A N HIS 232.A O no hydrogen 2.854 N/A LEU 197.A N ASP 194.A O no hydrogen 3.324 N/A LEU 197.A N ASP 194.A OD1 no hydrogen 3.165 N/A VAL 199.A N ASP 194.A O no hydrogen 2.935 N/A ASN 202.A N GLY 198.A O no hydrogen 2.791 N/A ILE 203.A N VAL 199.A O no hydrogen 2.879 N/A ALA 204.A N PRO 200.A O no hydrogen 3.215 N/A SER 205.A N PHE 201.A O no hydrogen 2.913 N/A TYR 206.A N ASN 202.A O no hydrogen 3.053 N/A TYR 206.A OH HIS 172.A ND1 no hydrogen 2.713 N/A SER 207.A N ILE 203.A O no hydrogen 3.039 N/A SER 207.A OG ILE 203.A O no hydrogen 2.859 N/A LEU 208.A N ALA 204.A O no hydrogen 2.896 N/A LEU 209.A N SER 205.A O no hydrogen 2.879 N/A THR 210.A N TYR 206.A O no hydrogen 2.938 N/A THR 210.A OG1 TYR 206.A O no hydrogen 2.884 N/A HIS 211.A N SER 207.A O no hydrogen 3.037 N/A HIS 211.A NE2 THR 46.A O no hydrogen 2.879 N/A LEU 212.A N LEU 208.A O no hydrogen 2.844 N/A MET 213.A N LEU 209.A O no hydrogen 2.833 N/A ALA 214.A N THR 210.A O no hydrogen 2.946 N/A SER 215.A N HIS 211.A O no hydrogen 3.133 N/A SER 215.A OG LEU 212.A O no hydrogen 2.766 N/A MET 216.A N LEU 212.A O no hydrogen 3.158 N/A MET 216.A N MET 213.A O no hydrogen 2.956 N/A VAL 217.A N ALA 214.A O no hydrogen 3.183 N/A LEU 219.A N ALA 214.A O no hydrogen 3.076 N/A LYS 220.A N GLY 182.A O no hydrogen 3.053 N/A GLY 222.A N LEU 184.A O no hydrogen 2.685 N/A GLU 223.A N SER 185.A OG no hydrogen 3.117 N/A PHE 224.A N PHE 40.A O no hydrogen 2.895 N/A ILE 225.A N CYS 186.A O no hydrogen 2.853 N/A LEU 226.A N MET 38.A O no hydrogen 2.851 N/A THR 227.A N LEU 188.A O no hydrogen 2.833 N/A THR 227.A OG1 GLN 187.A OE1 no hydrogen 2.712 N/A LEU 228.A N PRO 36.A O no hydrogen 2.927 N/A GLY 229.A N GLN 190.A O no hydrogen 2.778 N/A ASP 230.A N ARG 191.A O no hydrogen 2.953 N/A ALA 231.A N ILE 33.A O no hydrogen 2.955 N/A HIS 232.A N GLY 193.A O no hydrogen 3.047 N/A HIS 232.A ND1 ASP 230.A OD1 no hydrogen 3.052 N/A ILE 233.A N LEU 31.A O no hydrogen 2.884 N/A ASN 235.A N GLY 29.A O no hydrogen 2.911 N/A ASN 235.A ND2 THR 28.A O no hydrogen 3.651 N/A HIS 237.A N TYR 234.A O no hydrogen 2.857 N/A HIS 237.A NE2 LYS 287.A O no hydrogen 2.862 N/A ILE 238.A N ASN 235.A O no hydrogen 3.418 N/A LEU 241.A N HIS 237.A O no hydrogen 2.941 N/A LYS 242.A N ILE 238.A O no hydrogen 2.917 N/A LYS 243.A N GLU 239.A O no hydrogen 3.122 N/A GLN 244.A N VAL 240.A O no hydrogen 2.936 N/A GLN 244.A NE2 THR 52.A OG1 no hydrogen 2.954 N/A LEU 245.A N LEU 241.A O no hydrogen 2.980 N/A CYS 246.A N LYS 243.A O no hydrogen 3.044 N/A CYS 246.A SG LYS 242.A O no hydrogen 3.665 N/A ARG 247.A N GLN 244.A O no hydrogen 3.012 N/A ARG 247.A NH1 THR 52.A O no hydrogen 2.946 N/A ARG 247.A NH1 GLY 282.A O no hydrogen 3.133 N/A ARG 247.A NH2 GLY 282.A O no hydrogen 2.610 N/A ARG 250.A N THR 51.A OG1 no hydrogen 2.972 N/A ARG 250.A NH1 GLN 278.A O no hydrogen 2.997 N/A LYS 254.A N GLU 275.A O no hydrogen 3.017 N/A LYS 254.A NZ ASP 44.A O no hydrogen 2.761 N/A LEU 255.A N ASP 45.A O no hydrogen 2.793 N/A ARG 256.A N TYR 273.A O no hydrogen 2.911 N/A ARG 256.A NE GLU 275.A OE1 no hydrogen 3.117 N/A ARG 256.A NE GLU 275.A OE2 no hydrogen 3.085 N/A ARG 256.A NH2 GLU 275.A OE1 no hydrogen 2.667 N/A LEU 258.A N MET 271.A O no hydrogen 2.730 N/A GLU 265.A N GLU 265.A OE1 no hydrogen 2.858 N/A ASP 266.A N LYS 263.A O no hydrogen 2.835 N/A PHE 267.A N ILE 264.A O no hydrogen 3.082 N/A ASP 270.A N THR 268.A OG1 no hydrogen 3.343 N/A MET 271.A N THR 268.A O no hydrogen 2.947 N/A TYR 273.A N ARG 256.A O no hydrogen 2.939 N/A GLU 275.A N LYS 254.A O no hydrogen 2.781 N/A TYR 277.A OH LEU 50.A O no hydrogen 2.713 N/A TYR 277.A OH LYS 53.A O no hydrogen 3.416 N/A HIS 280.A N THR 51.A O no hydrogen 2.844 N/A HIS 280.A NE2 VAL 248.A O no hydrogen 2.845 N/A LYS 287.A NZ GLN 285.A O no hydrogen 3.121 N/A