Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8cum_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 4.A OG GLU 8.A OE2 no hydrogen 2.626 N/A GLN 6.A N SER 3.A OG no hydrogen 2.917 N/A HIS 7.A N SER 3.A O no hydrogen 3.088 N/A HIS 7.A ND1 ASN 239.A OD1 no hydrogen 2.671 N/A GLU 8.A N SER 4.A O no hydrogen 2.827 N/A LYS 9.A N GLN 5.A O no hydrogen 2.877 N/A ALA 10.A N GLN 6.A O no hydrogen 2.842 N/A ILE 11.A N HIS 7.A O no hydrogen 2.921 N/A LYS 12.A N GLU 8.A O no hydrogen 2.999 N/A LYS 12.A NZ ASP 16.A OD2 no hydrogen 2.808 N/A SER 13.A N LYS 9.A O no hydrogen 2.957 N/A SER 13.A OG ALA 10.A O no hydrogen 2.670 N/A TYR 14.A N ALA 10.A O no hydrogen 3.216 N/A TYR 14.A N ILE 11.A O no hydrogen 3.042 N/A ASP 16.A N LYS 12.A O no hydrogen 2.968 N/A GLU 17.A N SER 13.A O no hydrogen 2.785 N/A ALA 18.A N TYR 14.A O no hydrogen 3.295 N/A GLN 19.A N ASP 16.A O no hydrogen 2.912 N/A THR 20.A N PHE 15.A O no hydrogen 3.303 N/A THR 20.A OG1 GLU 219.A O no hydrogen 2.466 N/A GLY 22.A N ASN 37.A OD1 no hydrogen 2.824 N/A VAL 23.A N ASN 217.A O no hydrogen 2.816 N/A ILE 24.A N TYR 35.A O no hydrogen 2.780 N/A ILE 25.A N SER 215.A O no hydrogen 2.849 N/A ILE 26.A N SER 33.A O no hydrogen 2.828 N/A LYS 27.A N PRO 213.A O no hydrogen 2.941 N/A LYS 27.A NZ ASN 149.A OD1 no hydrogen 2.835 N/A LYS 27.A NZ ASP 152.A OD2 no hydrogen 2.839 N/A GLU 28.A N ASN 31.A O no hydrogen 2.906 N/A ASN 31.A N GLU 28.A O no hydrogen 3.000 N/A SER 33.A N ILE 26.A O no hydrogen 2.783 N/A SER 33.A OG.B ILE 26.A O no hydrogen 3.338 N/A TYR 35.A N ILE 24.A O no hydrogen 2.937 N/A ASN 37.A N GLY 22.A O no hydrogen 3.032 N/A ASN 37.A ND2 ASP 16.A OD1 no hydrogen 2.836 N/A ASN 37.A ND2 THR 20.A O no hydrogen 2.933 N/A ALA 38.A N GLY 22.A O no hydrogen 3.026 N/A ARG 41.A N ALA 38.A O no hydrogen 3.026 N/A ARG 41.A NE ASN 217.A OD1 no hydrogen 2.859 N/A ARG 41.A NH1 GLU 219.A OE1 no hydrogen 3.423 N/A ARG 41.A NH2 ASN 217.A OD1 no hydrogen 2.846 N/A ALA 42.A N LEU 39.A O no hydrogen 3.017 N/A LYS 44.A N ARG 41.A O no hydrogen 3.163 N/A TYR 46.A N ILE 142.A O no hydrogen 2.947 N/A SER 50.A OG SER 96.A OG no hydrogen 2.987 N/A THR 51.A N PRO 48.A O no hydrogen 3.147 N/A THR 51.A OG1 PRO 48.A O no hydrogen 2.684 N/A THR 51.A OG1 GLU 147.A OE1 no hydrogen 3.446 N/A THR 51.A OG1 GLU 147.A OE2 no hydrogen 2.639 N/A PHE 52.A N ALA 49.A O no hydrogen 3.032 N/A ASN 55.A N PHE 52.A O no hydrogen 2.811 N/A ASN 55.A ND2 TYR 101.A O no hydrogen 3.140 N/A LEU 57.A N MET 53.A O no hydrogen 3.168 N/A ILE 58.A N LEU 54.A O no hydrogen 2.854 N/A GLY 59.A N ASN 55.A O no hydrogen 2.810 N/A LEU 60.A N ALA 56.A O no hydrogen 2.910 N/A GLU 61.A N LEU 57.A O no hydrogen 2.926 N/A ASN 62.A N ILE 58.A O no hydrogen 3.081 N/A ASN 62.A ND2 ILE 58.A O no hydrogen 2.984 N/A ASN 62.A ND2 GLU 116.A OE1 no hydrogen 2.993 N/A HIS 63.A N LEU 60.A O no hydrogen 3.036 N/A LYS 64.A N GLY 59.A O no hydrogen 2.758 N/A THR 66.A OG1 ASN 68.A OD1 no hydrogen 2.839 N/A GLU 69.A N THR 66.A O no hydrogen 3.371 N/A PHE 71.A N MET 87.A O no hydrogen 2.770 N/A TRP 73.A N ASP 86.A OD1 no hydrogen 2.842 N/A TRP 73.A NE1 LYS 76.A O no hydrogen 2.757 N/A LYS 76.A N ASP 74.A OD1 no hydrogen 2.922 N/A ARG 78.A N GLU 84.A OE2 no hydrogen 2.926 N/A ARG 78.A NH1 ASP 74.A OD1 no hydrogen 2.775 N/A ARG 78.A NH1 ASP 74.A OD2 no hydrogen 3.490 N/A TRP 83.A N TYR 80.A O no hydrogen 3.075 N/A TRP 83.A NE1 LEU 95.A O no hydrogen 2.949 N/A GLU 84.A N PRO 81.A O no hydrogen 2.994 N/A LYS 85.A NZ ASP 86.A O no hydrogen 2.705 N/A LYS 85.A NZ GLU 91.A OE1 no hydrogen 3.500 N/A MET 87.A N PHE 71.A O no hydrogen 2.975 N/A THR 88.A N GLU 91.A OE1 no hydrogen 2.926 N/A GLU 91.A N THR 88.A OG1 no hydrogen 3.113 N/A ALA 92.A N THR 88.A O no hydrogen 2.852 N/A MET 93.A N LEU 89.A O no hydrogen 2.795 N/A ALA 94.A N GLY 90.A O no hydrogen 3.112 N/A LEU 95.A N GLU 91.A O no hydrogen 2.997 N/A SER 96.A N MET 93.A O no hydrogen 3.119 N/A ALA 97.A N ALA 92.A O no hydrogen 2.885 N/A VAL 100.A N ALA 97.A O no hydrogen 3.056 N/A TYR 101.A N ALA 97.A O no hydrogen 3.374 N/A TYR 101.A OH LEU 89.A O no hydrogen 2.768 N/A GLN 102.A N VAL 98.A O no hydrogen 2.804 N/A GLN 102.A NE2 ASP 132.A O no hydrogen 2.894 N/A GLU 103.A N PRO 99.A O no hydrogen 3.038 N/A LEU 104.A N VAL 100.A O no hydrogen 2.948 N/A ALA 105.A N TYR 101.A O no hydrogen 2.867 N/A ARG 106.A N GLN 102.A O no hydrogen 2.889 N/A ARG 106.A NH2 ASP 132.A OD2 no hydrogen 2.726 N/A ARG 107.A N GLU 103.A O no hydrogen 2.972 N/A ARG 107.A NE GLU 103.A OE1 no hydrogen 2.881 N/A ARG 107.A NH1 LYS 64.A O no hydrogen 2.923 N/A ARG 107.A NH1 GLU 69.A OE1 no hydrogen 3.306 N/A ARG 107.A NH1 GLU 69.A OE2 no hydrogen 2.810 N/A ARG 107.A NH2 GLU 69.A OE2 no hydrogen 2.954 N/A THR 108.A N LEU 104.A O no hydrogen 3.020 N/A THR 108.A OG1 LEU 104.A O no hydrogen 3.273 N/A GLY 109.A N ALA 105.A O no hydrogen 2.880 N/A MET 113.A N GLY 109.A O no hydrogen 2.906 N/A GLN 114.A N LEU 110.A O no hydrogen 2.884 N/A GLN 114.A NE2 GLN 114.A O no hydrogen 2.875 N/A GLN 114.A NE2 THR 125.A O no hydrogen 2.794 N/A LYS 115.A N GLU 111.A O no hydrogen 3.033 N/A LYS 115.A NZ GLU 111.A OE2 no hydrogen 3.544 N/A GLU 116.A N LEU 112.A O no hydrogen 2.820 N/A VAL 117.A N MET 113.A O no hydrogen 2.821 N/A LYS 118.A N GLN 114.A O no hydrogen 2.934 N/A ARG 119.A N LYS 115.A O no hydrogen 2.817 N/A ARG 119.A NE GLU 116.A OE2 no hydrogen 2.956 N/A ARG 119.A NH1 PRO 160.A O no hydrogen 2.743 N/A ARG 119.A NH2 GLU 116.A OE1 no hydrogen 2.988 N/A ARG 119.A NH2 PRO 160.A O no hydrogen 3.202 N/A VAL 120.A N GLU 116.A O no hydrogen 3.009 N/A ASN 121.A N LYS 118.A O no hydrogen 2.957 N/A PHE 122.A N VAL 117.A O no hydrogen 3.347 N/A ASN 124.A N LYS 141.A O no hydrogen 2.788 N/A ASN 124.A ND2 PRO 139.A O no hydrogen 3.005 N/A THR 125.A N PHE 122.A O no hydrogen 2.926 N/A THR 125.A OG1 ASN 124.A O no hydrogen 2.691 N/A ASN 126.A N ASN 124.A OD1 no hydrogen 3.133 N/A ILE 127.A N GLN 114.A OE1 no hydrogen 3.082 N/A GLY 128.A N ASN 126.A OD1.A no hydrogen 3.028 N/A GLN 130.A NE2.A THR 129.A OG1 no hydrogen 3.074 N/A ASN 133.A N GLN 130.A O no hydrogen 3.462 N/A ASN 133.A ND2 GLN 130.A OE1.B no hydrogen 3.274 N/A LEU 136.A N ASN 133.A O no hydrogen 2.918 N/A VAL 137.A N ASN 133.A O no hydrogen 3.285 N/A LYS 141.A N ASN 124.A OD1 no hydrogen 3.178 N/A ILE 142.A N TYR 46.A O no hydrogen 2.862 N/A THR 143.A N GLN 146.A OE1 no hydrogen 2.945 N/A VAL 145.A N ALA 42.A O no hydrogen 3.157 N/A GLN 146.A N THR 143.A OG1 no hydrogen 2.996 N/A GLU 147.A N THR 143.A O no hydrogen 2.850 N/A VAL 148.A N PRO 144.A O no hydrogen 2.926 N/A ASN 149.A N VAL 145.A O no hydrogen 2.964 N/A PHE 150.A N GLN 146.A O no hydrogen 2.814 N/A ALA 151.A N GLU 147.A O no hydrogen 2.909 N/A ASP 152.A N VAL 148.A O no hydrogen 2.871 N/A ASP 153.A N ASN 149.A O no hydrogen 2.943 N/A LEU 154.A N PHE 150.A O no hydrogen 2.887 N/A ALA 155.A N ALA 151.A O no hydrogen 2.843 N/A HIS 156.A N ASP 152.A O no hydrogen 3.187 N/A HIS 156.A N ASP 153.A O no hydrogen 3.233 N/A HIS 156.A ND1 ASP 152.A O no hydrogen 2.908 N/A ASN 157.A N LEU 154.A O no hydrogen 3.028 N/A ASN 157.A ND2 GLU 167.A OE2 no hydrogen 3.126 N/A ARG 158.A N ASP 153.A O no hydrogen 2.784 N/A ARG 158.A NH1 ASP 152.A OD2 no hydrogen 3.162 N/A ARG 158.A NH1 ASP 153.A OD1 no hydrogen 3.152 N/A LEU 159.A N GLN 166.A OE1 no hydrogen 3.137 N/A PHE 161.A N LEU 159.A O no hydrogen 2.817 N/A LYS 162.A N GLU 61.A OE1 no hydrogen 3.050 N/A LYS 162.A N GLU 61.A OE2 no hydrogen 3.290 N/A THR 165.A OG1 GLU 61.A OE1 no hydrogen 2.711 N/A GLN 166.A N LYS 162.A O no hydrogen 3.098 N/A GLN 166.A NE2 ASN 157.A O no hydrogen 3.341 N/A GLN 166.A NE2 PHE 161.A O no hydrogen 3.046 N/A GLU 167.A N LEU 163.A O no hydrogen 2.877 N/A GLU 168.A N GLU 164.A O no hydrogen 2.903 N/A VAL 169.A N THR 165.A O no hydrogen 3.070 N/A LYS 170.A N GLN 166.A O no hydrogen 2.875 N/A LYS 170.A NZ LEU 154.A O no hydrogen 3.414 N/A LYS 170.A NZ ALA 155.A O no hydrogen 3.198 N/A LYS 170.A NZ ASN 157.A OD1 no hydrogen 2.620 N/A LYS 170.A NZ GLU 167.A OE2 no hydrogen 3.457 N/A LYS 171.A N GLU 167.A O no hydrogen 3.054 N/A MET 172.A N VAL 169.A O no hydrogen 2.890 N/A LEU 173.A N LYS 170.A O no hydrogen 2.970 N/A ILE 175.A N ILE 183.A O no hydrogen 2.878 N/A LYS 176.A N ILE 183.A O no hydrogen 3.320 N/A VAL 178.A N SER 181.A O no hydrogen 2.962 N/A SER 181.A N VAL 178.A O no hydrogen 2.585 N/A LYS 182.A N GLU 205.A O no hydrogen 2.929 N/A ILE 183.A N LYS 176.A O no hydrogen 2.806 N/A TYR 184.A N TRP 203.A O no hydrogen 2.923 N/A ALA 185.A N LEU 173.A O no hydrogen 2.889 N/A LYS 186.A N THR 201.A O no hydrogen 2.874 N/A LYS 186.A NZ SER 96.A OG no hydrogen 2.931 N/A LYS 186.A NZ SER 187.A O no hydrogen 2.825 N/A GLY 188.A N TRP 199.A O no hydrogen 2.910 N/A TRP 189.A NE1 GLN 196.A OE1.A no hydrogen 2.911 N/A TRP 189.A NE1 GLN 196.A OE1.B no hydrogen 2.976 N/A GLY 190.A N VAL 197.A O no hydrogen 2.766 N/A MET 191.A SD.B TYR 80.A OH no hydrogen 3.696 N/A THR 194.A OG1.B VAL 193.A O.A no hydrogen 2.797 N/A GLN 196.A N.A MET 220.A O no hydrogen 2.904 N/A GLN 196.A NE2.A GLY 192.A O.A no hydrogen 2.972 N/A GLN 196.A NE2.B GLY 192.A O.A no hydrogen 2.612 N/A GLY 198.A N LEU 218.A O no hydrogen 2.767 N/A TRP 199.A N GLY 188.A O no hydrogen 2.885 N/A TRP 199.A NE1 VAL 47.A O no hydrogen 2.871 N/A LEU 200.A N LEU 216.A O no hydrogen 2.966 N/A THR 201.A N LYS 186.A O no hydrogen 3.085 N/A THR 201.A OG1 GLU 147.A OE1 no hydrogen 2.655 N/A THR 201.A OG1 SER 215.A OG no hydrogen 2.891 N/A GLY 202.A N PHE 214.A O no hydrogen 2.943 N/A TRP 203.A N TYR 184.A O no hydrogen 2.702 N/A VAL 204.A N ILE 212.A O no hydrogen 2.912 N/A GLU 205.A N LYS 182.A O no hydrogen 2.715 N/A GLN 206.A N LYS 210.A O no hydrogen 2.848 N/A GLN 206.A NE2 ILE 242.A O no hydrogen 2.912 N/A GLY 209.A N GLN 206.A O no hydrogen 2.705 N/A LYS 210.A N ASN 208.A OD1 no hydrogen 3.002 N/A LYS 211.A NZ ALA 155.A O no hydrogen 2.973 N/A ILE 212.A N VAL 204.A O no hydrogen 2.869 N/A PHE 214.A N GLY 202.A O no hydrogen 2.882 N/A SER 215.A N ILE 25.A O no hydrogen 2.886 N/A SER 215.A OG THR 201.A OG1 no hydrogen 2.891 N/A LEU 216.A N LEU 200.A O no hydrogen 2.842 N/A ASN 217.A N VAL 23.A O no hydrogen 2.897 N/A LEU 218.A N GLY 198.A O no hydrogen 2.890 N/A GLU 219.A N GLN 21.A O no hydrogen 3.041 N/A MET 220.A N GLN 196.A O.A no hydrogen 2.545 N/A LYS 221.A NZ GLN 21.A OE1.B no hydrogen 2.810 N/A LYS 221.A NZ GLU 219.A OE2 no hydrogen 2.523 N/A MET 224.A N LYS 221.A O no hydrogen 3.141 N/A SER 225.A OG.A SER 227.A OG no hydrogen 2.805 N/A SER 227.A N SER 225.A OG.A no hydrogen 3.134 N/A SER 227.A OG SER 225.A OG.A no hydrogen 2.805 N/A SER 227.A OG GLU 231.A OE2 no hydrogen 3.283 N/A ILE 228.A N SER 225.A O no hydrogen 3.040 N/A ARG 229.A N GLY 226.A O no hydrogen 3.113 N/A ARG 229.A NE GLY 226.A O no hydrogen 2.805 N/A ARG 229.A NH1 GLY 188.A O no hydrogen 2.776 N/A ARG 229.A NH2 GLY 226.A O no hydrogen 3.421 N/A ASN 230.A ND2 TYR 234.A OH no hydrogen 3.114 N/A GLU 231.A N SER 227.A O no hydrogen 2.831 N/A ILE 232.A N ILE 228.A O no hydrogen 2.921 N/A THR 233.A N ARG 229.A O no hydrogen 3.103 N/A THR 233.A OG1 ARG 229.A O no hydrogen 2.780 N/A TYR 234.A N ASN 230.A O no hydrogen 2.812 N/A LYS 235.A N GLU 231.A O no hydrogen 2.977 N/A SER 236.A N ILE 232.A O no hydrogen 2.936 N/A SER 236.A OG ILE 232.A O no hydrogen 2.775 N/A LEU 237.A N THR 233.A O no hydrogen 2.880 N/A GLU 238.A N TYR 234.A O no hydrogen 2.851 N/A ASN 239.A N LYS 235.A O no hydrogen 2.842 N/A LEU 240.A N SER 236.A O no hydrogen 3.091 N/A GLY 241.A N GLU 238.A O no hydrogen 2.894 N/A ILE 242.A N LEU 237.A O no hydrogen 2.820 N/A ILE 243.A N LEU 237.A O no hydrogen 3.489 N/A