Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8cxh_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 1.A N ASP 42.A OD2 no hydrogen 3.066 N/A SER 7.A OG VAL 6.A O no hydrogen 2.438 N/A ARG 9.A NH2 THR 315.A OG1 no hydrogen 3.363 N/A ARG 9.A NH2 GLU 367.A OE1 no hydrogen 3.495 N/A ASP 10.A N CYS 30.A O no hydrogen 2.895 N/A VAL 12.A N THR 32.A O no hydrogen 2.925 N/A GLY 14.A N MET 34.A O no hydrogen 2.621 N/A VAL 21.A N LEU 283.A O no hydrogen 2.925 N/A LEU 25.A N LEU 279.A O no hydrogen 2.834 N/A VAL 31.A N ILE 43.A O no hydrogen 2.965 N/A THR 32.A N ASP 10.A O no hydrogen 2.904 N/A VAL 33.A N VAL 41.A O no hydrogen 2.865 N/A MET 34.A N VAL 12.A O no hydrogen 2.976 N/A LYS 38.A NZ MET 285.A O no hydrogen 2.563 N/A THR 40.A OG1 ILE 349.A O no hydrogen 2.706 N/A VAL 41.A N VAL 33.A O no hydrogen 2.994 N/A ASP 42.A N SER 142.A O no hydrogen 2.886 N/A ILE 43.A N VAL 31.A O no hydrogen 2.861 N/A GLU 44.A N MET 140.A O no hydrogen 2.930 N/A VAL 46.A N ARG 138.A O no hydrogen 2.957 N/A THR 48.A N LEU 274.A O no hydrogen 3.103 N/A THR 48.A OG1 LEU 274.A O no hydrogen 3.176 N/A THR 49.A N GLU 136.A O no hydrogen 2.969 N/A VAL 50.A N GLY 272.A O no hydrogen 2.860 N/A SER 51.A N ASN 134.A O no hydrogen 3.328 N/A SER 51.A OG ASN 134.A O no hydrogen 2.503 N/A VAL 56.A N GLY 127.A O no hydrogen 2.877 N/A ARG 57.A NH2 TYR 59.A OH no hydrogen 3.207 N/A TYR 59.A N MET 125.A O no hydrogen 2.659 N/A TYR 59.A OH PHE 208.A O no hydrogen 2.847 N/A CYS 60.A SG GLU 62.A O no hydrogen 3.552 N/A SER 64.A N ALA 120.A O no hydrogen 2.818 N/A SER 66.A OG ASP 67.A OD1 no hydrogen 3.134 N/A ASP 67.A N SER 66.A OG no hydrogen 2.581 N/A ALA 69.A N CYS 116.A O no hydrogen 2.910 N/A ASP 71.A N VAL 114.A O no hydrogen 2.903 N/A ARG 73.A N SER 112.A O no hydrogen 3.216 N/A ALA 80.A N SER 112.A OG no hydrogen 2.517 N/A GLN 85.A N LEU 82.A O no hydrogen 2.997 N/A SER 86.A OG ASP 83.A O no hydrogen 3.163 N/A VAL 91.A N ALA 117.A O no hydrogen 2.897 N/A CYS 92.A SG LYS 84.A O no hydrogen 3.890 N/A LYS 93.A N THR 115.A O no hydrogen 2.918 N/A ARG 94.A NH2 ALA 80.A O no hydrogen 2.235 N/A THR 95.A N LEU 113.A O no hydrogen 2.884 N/A VAL 97.A N GLY 111.A O no hydrogen 2.876 N/A ASP 98.A N ALA 240.A O no hydrogen 2.821 N/A TRP 101.A N CYS 105.A O no hydrogen 2.511 N/A ASN 103.A ND2 ASP 98.A O no hydrogen 3.579 N/A LEU 107.A N CYS 105.A O no hydrogen 2.969 N/A LYS 110.A NZ ASP 98.A OD1 no hydrogen 2.901 N/A GLY 111.A N VAL 97.A O no hydrogen 2.884 N/A LEU 113.A N THR 95.A O no hydrogen 2.875 N/A VAL 114.A N ASP 71.A O no hydrogen 2.910 N/A THR 115.A N LYS 93.A O no hydrogen 2.943 N/A THR 115.A OG1 LYS 93.A O no hydrogen 3.547 N/A THR 115.A OG1 GLN 243.A OE1 no hydrogen 2.283 N/A CYS 116.A N ALA 69.A O no hydrogen 2.920 N/A ALA 117.A N VAL 91.A O no hydrogen 2.920 N/A PHE 119.A N GLN 89.A O no hydrogen 2.868 N/A ALA 120.A N SER 64.A O no hydrogen 2.916 N/A CYS 121.A SG GLU 62.A O no hydrogen 3.654 N/A CYS 121.A SG SER 122.A O no hydrogen 3.742 N/A SER 122.A N GLU 62.A O no hydrogen 2.954 N/A SER 122.A OG GLU 62.A O no hydrogen 3.454 N/A MET 125.A N TYR 59.A O no hydrogen 2.765 N/A THR 126.A N THR 195.A O no hydrogen 2.943 N/A THR 126.A OG1 THR 195.A OG1 no hydrogen 3.137 N/A LYS 128.A N TYR 193.A O no hydrogen 2.883 N/A SER 129.A N ALA 54.A O no hydrogen 2.899 N/A SER 129.A OG ALA 54.A O no hydrogen 3.405 N/A ASN 134.A ND2 GLN 131.A OE1 no hydrogen 3.603 N/A GLU 136.A N THR 49.A O no hydrogen 2.959 N/A TYR 137.A N ILE 159.A O no hydrogen 2.891 N/A TYR 137.A OH PRO 182.A O no hydrogen 2.916 N/A ARG 138.A N THR 47.A O no hydrogen 3.097 N/A ILE 139.A N VAL 157.A O no hydrogen 2.894 N/A MET 140.A N GLU 44.A O no hydrogen 2.893 N/A LEU 141.A N ALA 155.A O no hydrogen 2.968 N/A SER 142.A N ASP 42.A O no hydrogen 2.905 N/A SER 142.A OG ILE 1.A O no hydrogen 2.791 N/A VAL 143.A N ASN 153.A O no hydrogen 2.839 N/A HIS 144.A N THR 40.A O no hydrogen 3.231 N/A SER 146.A OG THR 356.A OG1 no hydrogen 3.397 N/A ALA 155.A N LEU 141.A O no hydrogen 2.885 N/A LYS 156.A NZ GLU 158.A OE2 no hydrogen 2.691 N/A VAL 157.A N ILE 139.A O no hydrogen 2.869 N/A ILE 159.A N TYR 137.A O no hydrogen 2.911 N/A SER 163.A N THR 160.A O no hydrogen 2.764 N/A SER 163.A OG SER 163.A O no hydrogen 2.404 N/A ALA 166.A N LEU 178.A O no hydrogen 2.905 N/A ALA 168.A N LEU 176.A O no hydrogen 2.918 N/A LEU 170.A N GLY 174.A O no hydrogen 2.919 N/A PHE 173.A N LEU 170.A O no hydrogen 2.921 N/A SER 175.A N LYS 287.A O no hydrogen 3.290 N/A SER 175.A OG GLU 167.A OE1 no hydrogen 3.533 N/A LEU 176.A N ALA 168.A O no hydrogen 2.926 N/A GLY 177.A N LYS 284.A O no hydrogen 2.997 N/A LEU 178.A N ALA 166.A O no hydrogen 2.893 N/A ASP 179.A N ARG 282.A O no hydrogen 2.944 N/A CYS 180.A N PRO 164.A O no hydrogen 3.116 N/A GLU 181.A N LYS 280.A O no hydrogen 2.873 N/A ARG 183.A NH2 GLU 133.A OE2 no hydrogen 2.980 N/A SER 189.A N ASP 187.A O no hydrogen 2.334 N/A ASP 190.A N ASP 187.A O no hydrogen 3.331 N/A TYR 192.A N VAL 203.A O no hydrogen 2.814 N/A TYR 193.A N LYS 128.A O no hydrogen 2.852 N/A TYR 193.A OH GLU 266.A O no hydrogen 2.677 N/A LEU 194.A N TRP 201.A O no hydrogen 2.883 N/A THR 195.A N THR 126.A O no hydrogen 2.908 N/A THR 195.A OG1 THR 126.A O no hydrogen 3.443 N/A MET 196.A N LYS 199.A O no hydrogen 3.271 N/A TRP 201.A N LEU 194.A O no hydrogen 2.828 N/A LEU 202.A N LEU 263.A O no hydrogen 2.795 N/A VAL 203.A N TYR 192.A O no hydrogen 2.926 N/A HIS 204.A ND1 LYS 205.A O no hydrogen 2.228 N/A LYS 205.A N ASP 190.A O no hydrogen 2.353 N/A PHE 208.A N HIS 204.A O no hydrogen 3.372 N/A LEU 213.A N ILE 211.A O no hydrogen 3.147 N/A HIS 216.A N SER 58.A O no hydrogen 3.008 N/A ASP 220.A N ASP 220.A OD1 no hydrogen 2.411 N/A ASN 227.A N TRP 215.A O no hydrogen 3.146 N/A ASN 227.A ND2 TRP 215.A O no hydrogen 3.462 N/A LYS 229.A NZ THR 88.A O no hydrogen 2.575 N/A GLU 230.A N ASN 228.A O no hydrogen 2.360 N/A GLU 234.A N VAL 246.A O no hydrogen 2.846 N/A ALA 240.A N ALA 238.A O no hydrogen 2.473 N/A THR 244.A N LYS 236.A O no hydrogen 2.869 N/A THR 244.A OG1 LYS 236.A O no hydrogen 3.459 N/A VAL 246.A N GLU 234.A O no hydrogen 2.964 N/A LEU 248.A N LEU 232.A O no hydrogen 2.999 N/A SER 250.A N LEU 248.A O no hydrogen 3.142 N/A SER 250.A OG GLU 62.A OE2 no hydrogen 3.547 N/A GLN 251.A N GLY 249.A O no hydrogen 2.696 N/A VAL 255.A N GLN 251.A O no hydrogen 3.381 N/A HIS 256.A N GLU 252.A O no hydrogen 3.374 N/A THR 257.A OG1 ALA 254.A O no hydrogen 3.191 N/A ALA 258.A N ALA 254.A O no hydrogen 2.936 N/A LEU 259.A N VAL 255.A O no hydrogen 2.795 N/A LEU 263.A N LEU 202.A O no hydrogen 3.020 N/A ALA 265.A N HIS 200.A O no hydrogen 2.912 N/A GLU 266.A N ARG 273.A O no hydrogen 2.971 N/A ASP 268.A N LYS 271.A O no hydrogen 2.895 N/A LYS 271.A N ASP 268.A O no hydrogen 2.941 N/A GLY 272.A N VAL 50.A O no hydrogen 2.897 N/A ARG 273.A N GLU 266.A O no hydrogen 2.850 N/A LEU 274.A N THR 48.A O no hydrogen 2.837 N/A SER 275.A OG SER 275.A O no hydrogen 2.376 N/A LEU 279.A N LEU 25.A O no hydrogen 2.897 N/A LYS 280.A NZ ASP 22.A OD2 no hydrogen 3.203 N/A LYS 280.A NZ GLU 181.A OE2 no hydrogen 3.256 N/A CYS 281.A N VAL 23.A O no hydrogen 2.884 N/A ARG 282.A N ASP 179.A O no hydrogen 2.834 N/A ARG 282.A NE ASP 22.A OD1 no hydrogen 2.966 N/A LEU 283.A N VAL 21.A O no hydrogen 2.863 N/A LYS 284.A N GLY 177.A O no hydrogen 2.817 N/A MET 285.A N THR 19.A O no hydrogen 3.264 N/A ARG 289.A N PHE 173.A O no hydrogen 2.815 N/A LYS 291.A NZ GLU 152.A OE2 no hydrogen 2.390 N/A SER 294.A OG VAL 293.A O no hydrogen 2.324 N/A CYS 298.A N LYS 330.A O no hydrogen 3.033 N/A CYS 298.A SG LYS 330.A O no hydrogen 3.070 N/A THR 299.A OG1 THR 299.A O no hydrogen 2.423 N/A THR 303.A N GLN 321.A O no hydrogen 2.960 N/A THR 305.A N GLU 319.A O no hydrogen 3.157 N/A THR 305.A OG1 GLU 319.A O no hydrogen 3.357 N/A LYS 306.A NZ SER 149.A OG no hydrogen 3.100 N/A ALA 309.A N THR 317.A O no hydrogen 2.945 N/A THR 311.A N THR 315.A O no hydrogen 2.945 N/A THR 311.A OG1 THR 315.A O no hydrogen 3.530 N/A THR 311.A OG1 THR 315.A OG1 no hydrogen 2.512 N/A THR 315.A OG1 THR 311.A OG1 no hydrogen 2.512 N/A THR 315.A OG1 GLU 367.A OE2 no hydrogen 2.274 N/A VAL 316.A N LEU 368.A O no hydrogen 2.892 N/A THR 317.A N ALA 309.A O no hydrogen 2.898 N/A VAL 318.A N LEU 366.A O no hydrogen 2.871 N/A VAL 320.A N MET 364.A O no hydrogen 2.872 N/A GLN 321.A N THR 303.A O no hydrogen 2.898 N/A TYR 322.A N SER 362.A O no hydrogen 2.871 N/A TYR 322.A OH ASP 326.A OD2 no hydrogen 3.048 N/A ALA 323.A N ALA 301.A O no hydrogen 3.491 N/A THR 325.A OG1 THR 325.A O no hydrogen 2.507 N/A CYS 329.A N ILE 355.A O no hydrogen 2.745 N/A CYS 329.A SG SER 296.A O no hydrogen 2.999 N/A CYS 329.A SG LYS 330.A O no hydrogen 3.666 N/A LYS 330.A N SER 296.A O no hydrogen 3.131 N/A VAL 331.A N PRO 353.A O no hydrogen 3.131 N/A GLN 334.A N VAL 378.A O no hydrogen 2.957 N/A ALA 336.A N TYR 376.A O no hydrogen 2.871 N/A THR 341.A OG1 THR 341.A O no hydrogen 2.429 N/A THR 343.A OG1 THR 341.A O no hydrogen 3.506 N/A VAL 345.A N MET 335.A O no hydrogen 3.110 N/A ARG 347.A N ASP 369.A O no hydrogen 2.959 N/A THR 350.A N GLU 367.A O no hydrogen 3.001 N/A ILE 355.A N CYS 329.A O no hydrogen 2.621 N/A THR 359.A OG1 SER 362.A OG no hydrogen 3.274 N/A SER 362.A N TYR 322.A O no hydrogen 2.998 N/A SER 362.A OG THR 359.A OG1 no hydrogen 3.274 N/A LYS 363.A NZ GLU 319.A OE2 no hydrogen 2.836 N/A MET 364.A N VAL 320.A O no hydrogen 2.950 N/A LEU 366.A N VAL 318.A O no hydrogen 2.914 N/A LEU 368.A N VAL 316.A O no hydrogen 2.903 N/A ASP 369.A N ARG 347.A O no hydrogen 2.476 N/A SER 375.A N TRP 390.A O no hydrogen 2.919 N/A TYR 376.A N ALA 336.A O no hydrogen 2.870 N/A ILE 377.A N HIS 388.A O no hydrogen 2.853 N/A VAL 378.A N GLN 334.A O no hydrogen 2.903 N/A ILE 379.A N ILE 386.A O no hydrogen 2.936 N/A GLY 380.A N PRO 332.A O no hydrogen 3.365 N/A ILE 386.A N ILE 379.A O no hydrogen 2.891 N/A HIS 388.A N ILE 377.A O no hydrogen 2.948 N/A TRP 390.A N SER 375.A O no hydrogen 2.871 N/A HIS 391.A ND1 ASP 374.A OD1 no hydrogen 2.477 N/A ARG 392.A NH2 PRO 370.A O no hydrogen 2.466 N/A LYS 399.A N SER 395.A O no hydrogen 3.362 N/A ALA 400.A N THR 396.A O no hydrogen 2.918 N/A PHE 401.A N ILE 397.A O no hydrogen 2.948 N/A GLU 402.A N GLY 398.A O no hydrogen 2.902 N/A ALA 403.A N LYS 399.A O no hydrogen 2.892 N/A THR 404.A N ALA 400.A O no hydrogen 2.951 N/A THR 404.A OG1 ALA 400.A O no hydrogen 3.349 N/A THR 404.A OG1 PHE 401.A O no hydrogen 2.604 N/A VAL 405.A N PHE 401.A O no hydrogen 2.943 N/A ARG 406.A N GLU 402.A O no hydrogen 2.900 N/A GLY 407.A N ALA 403.A O no hydrogen 2.908 N/A ALA 408.A N THR 404.A O no hydrogen 2.898 N/A LYS 409.A N VAL 405.A O no hydrogen 2.946 N/A ARG 410.A N ARG 406.A O no hydrogen 2.897 N/A MET 411.A N GLY 407.A O no hydrogen 2.911 N/A ALA 412.A N ALA 408.A O no hydrogen 2.909 N/A VAL 413.A N LYS 409.A O no hydrogen 2.940 N/A LEU 414.A N ARG 410.A O no hydrogen 2.892 N/A GLY 415.A N MET 411.A O no hydrogen 2.861 N/A THR 417.A OG1 LEU 414.A O no hydrogen 3.506 N/A TRP 419.A N ASP 416.A O no hydrogen 3.270 N/A TRP 419.A NE1 HIS 436.A ND1 no hydrogen 2.988 N/A ASP 420.A N THR 417.A O no hydrogen 2.873 N/A SER 423.A OG ASP 22.A OD2 no hydrogen 3.492 N/A SER 423.A OG ASP 420.A OD1 no hydrogen 3.213 N/A SER 423.A OG SER 423.A O no hydrogen 2.404 N/A VAL 424.A N GLY 422.A O no hydrogen 2.724 N/A ASN 429.A ND2 TRP 419.A O no hydrogen 2.960 N/A SER 430.A N GLY 426.A O no hydrogen 3.015 N/A LEU 431.A N ALA 427.A O no hydrogen 2.900 N/A GLY 432.A N LEU 428.A O no hydrogen 2.927 N/A LYS 433.A N ASN 429.A O no hydrogen 2.934 N/A LYS 433.A NZ ASP 416.A OD2 no hydrogen 3.004 N/A GLY 434.A N SER 430.A O no hydrogen 2.907 N/A ILE 435.A N LEU 431.A O no hydrogen 2.965 N/A HIS 436.A N GLY 432.A O no hydrogen 2.911 N/A GLN 437.A N LYS 433.A O no hydrogen 2.897 N/A GLN 437.A NE2 ASP 416.A OD2 no hydrogen 2.973 N/A ILE 438.A N GLY 434.A O no hydrogen 3.021 N/A PHE 439.A N ILE 435.A O no hydrogen 2.962 N/A GLY 440.A N HIS 436.A O no hydrogen 2.808 N/A ALA 441.A N GLN 437.A O no hydrogen 2.947 N/A ALA 442.A N ILE 438.A O no hydrogen 3.024 N/A PHE 443.A N PHE 439.A O no hydrogen 2.882 N/A LYS 444.A N GLY 440.A O no hydrogen 2.884 N/A SER 445.A N ALA 441.A O no hydrogen 2.949 N/A LEU 446.A N ALA 442.A O no hydrogen 2.950 N/A PHE 447.A N PHE 443.A O no hydrogen 2.897 N/A SER 451.A OG SER 451.A O no hydrogen 2.441 N/A PHE 453.A N SER 451.A O no hydrogen 2.550 N/A LEU 457.A N PHE 453.A O no hydrogen 2.727 N/A ILE 458.A N SER 454.A O no hydrogen 2.922 N/A GLY 459.A N GLN 455.A O no hydrogen 2.833 N/A THR 460.A N ILE 456.A O no hydrogen 2.949 N/A THR 460.A OG1 ILE 456.A O no hydrogen 3.218 N/A LEU 461.A N LEU 457.A O no hydrogen 2.924 N/A LEU 462.A N ILE 458.A O no hydrogen 2.918 N/A MET 463.A N GLY 459.A O no hydrogen 2.848 N/A TRP 464.A N THR 460.A O no hydrogen 2.975 N/A LEU 465.A N LEU 461.A O no hydrogen 2.944 N/A GLY 466.A N LEU 462.A O no hydrogen 2.840 N/A LEU 467.A N MET 463.A O no hydrogen 2.889 N/A ASN 468.A N TRP 464.A O no hydrogen 2.995 N/A GLY 472.A N ASN 471.A OD1 no hydrogen 2.291 N/A MET 477.A N SER 473.A O no hydrogen 3.118 N/A CYS 478.A N ILE 474.A O no hydrogen 2.944 N/A CYS 478.A SG ILE 474.A O no hydrogen 3.546 N/A LEU 479.A N SER 475.A O no hydrogen 2.882 N/A ALA 480.A N LEU 476.A O no hydrogen 3.002 N/A LEU 481.A N MET 477.A O no hydrogen 2.857 N/A GLY 482.A N CYS 478.A O no hydrogen 2.874 N/A GLY 483.A N LEU 479.A O no hydrogen 2.971 N/A VAL 484.A N ALA 480.A O no hydrogen 2.896 N/A LEU 485.A N LEU 481.A O no hydrogen 2.801 N/A ILE 486.A N GLY 482.A O no hydrogen 2.963 N/A PHE 487.A N GLY 483.A O no hydrogen 2.930 N/A LEU 488.A N VAL 484.A O no hydrogen 2.995 N/A SER 489.A N LEU 485.A O no hydrogen 2.893 N/A SER 489.A OG SER 489.A O no hydrogen 2.494 N/A