Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8e3x_B.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLN 4.A NE2 GLU 8.A OE1 no hydrogen 3.402 N/A LEU 5.A N GLU 1.A O no hydrogen 3.113 N/A ARG 6.A N LEU 2.A O no hydrogen 2.905 N/A GLN 7.A N ASP 3.A O no hydrogen 2.906 N/A GLU 8.A N GLN 4.A O no hydrogen 2.906 N/A ALA 9.A N LEU 5.A O no hydrogen 2.899 N/A GLU 10.A N ARG 6.A O no hydrogen 2.904 N/A GLN 11.A N GLN 7.A O no hydrogen 2.902 N/A LEU 12.A N GLU 8.A O no hydrogen 2.910 N/A LYS 13.A N ALA 9.A O no hydrogen 2.894 N/A ASN 14.A N GLU 10.A O no hydrogen 2.920 N/A GLN 15.A N GLN 11.A O no hydrogen 2.890 N/A ILE 16.A N LEU 12.A O no hydrogen 2.915 N/A ARG 17.A N LYS 13.A O no hydrogen 2.901 N/A ARG 17.A NH2 ASN 14.A OD1 no hydrogen 3.035 N/A ASP 18.A N ASN 14.A O no hydrogen 2.885 N/A ALA 19.A N GLN 15.A O no hydrogen 2.908 N/A ARG 20.A N ILE 16.A O no hydrogen 2.909 N/A ARG 20.A NH2 THR 219.A O no hydrogen 3.095 N/A ARG 20.A NH2 ASP 256.A OD1 no hydrogen 2.923 N/A LYS 21.A N ARG 17.A O no hydrogen 2.895 N/A ALA 22.A N ASP 18.A O no hydrogen 2.898 N/A CYS 23.A N ALA 19.A O no hydrogen 2.904 N/A ALA 24.A N LYS 21.A O no hydrogen 3.235 N/A THR 27.A N GLN 30.A OE1 no hydrogen 3.245 N/A THR 27.A OG1 SER 29.A OG no hydrogen 3.215 N/A SER 29.A OG THR 27.A OG1 no hydrogen 3.215 N/A ILE 31.A N THR 27.A O no hydrogen 3.272 N/A THR 32.A N LEU 28.A O no hydrogen 2.912 N/A THR 32.A OG1 LEU 28.A O no hydrogen 2.546 N/A THR 32.A OG1 SER 29.A O no hydrogen 3.194 N/A THR 32.A OG1 LEU 298.A O no hydrogen 2.540 N/A ASN 33.A N GLN 30.A O no hydrogen 3.462 N/A ILE 35.A N THR 32.A O no hydrogen 3.318 N/A ILE 41.A N ALA 303.A O no hydrogen 3.123 N/A ARG 44.A NH1 MET 43.A O no hydrogen 3.502 N/A ARG 44.A NH2 GLN 42.A OE1 no hydrogen 3.547 N/A ARG 47.A N ILE 336.A O no hydrogen 2.970 N/A ARG 47.A NE SER 82.A O no hydrogen 3.389 N/A ARG 47.A NH2 TYR 83.A O no hydrogen 2.671 N/A LEU 49.A N LEU 334.A O no hydrogen 2.873 N/A HIS 52.A NE2 SER 70.A OG no hydrogen 2.547 N/A LEU 53.A N ASP 74.A OD2 no hydrogen 2.858 N/A ILE 56.A N SER 329.A O no hydrogen 3.443 N/A TYR 57.A N ALA 71.A O no hydrogen 2.976 N/A HIS 60.A N VAL 69.A O no hydrogen 3.036 N/A THR 63.A OG1 PRO 105.A O no hydrogen 2.932 N/A SER 65.A N GLY 62.A O no hydrogen 3.070 N/A SER 65.A OG ASP 321.A OD1 no hydrogen 3.055 N/A ARG 66.A N ASP 64.A OD1 no hydrogen 3.475 N/A ARG 66.A NE ASP 81.A OD1 no hydrogen 3.121 N/A LEU 68.A N TRP 80.A O no hydrogen 2.953 N/A VAL 69.A N HIS 60.A O no hydrogen 3.151 N/A SER 70.A N ILE 78.A O no hydrogen 2.900 N/A SER 70.A OG HIS 52.A NE2 no hydrogen 2.547 N/A SER 70.A OG ILE 78.A O no hydrogen 3.475 N/A ALA 71.A N ALA 58.A O no hydrogen 3.014 N/A SER 72.A N LYS 76.A O no hydrogen 2.993 N/A SER 72.A OG ALA 54.A O no hydrogen 2.836 N/A SER 72.A OG LYS 55.A O no hydrogen 3.000 N/A SER 72.A OG ASP 74.A OD1 no hydrogen 3.210 N/A GLN 73.A N LYS 55.A O no hydrogen 3.085 N/A LEU 77.A N ILE 91.A O no hydrogen 2.943 N/A ILE 78.A N SER 70.A O no hydrogen 2.904 N/A ILE 79.A N HIS 89.A O no hydrogen 2.867 N/A TRP 80.A N LEU 68.A O no hydrogen 2.845 N/A ASP 81.A N ASN 86.A O no hydrogen 3.017 N/A SER 82.A N ARG 66.A O no hydrogen 2.895 N/A SER 82.A OG ARG 66.A O no hydrogen 2.619 N/A THR 84.A OG1 ASP 81.A OD2 no hydrogen 3.061 N/A LYS 87.A NZ ARG 50.A O no hydrogen 3.355 N/A VAL 88.A N ILE 79.A O no hydrogen 2.760 N/A HIS 89.A N ILE 79.A O no hydrogen 2.973 N/A ILE 91.A N LEU 77.A O no hydrogen 2.880 N/A LEU 93.A N GLY 75.A O no hydrogen 2.762 N/A MET 99.A N GLY 113.A O no hydrogen 2.889 N/A THR 100.A N GLY 113.A O no hydrogen 3.311 N/A CYS 101.A SG VAL 69.A O no hydrogen 3.952 N/A ALA 102.A N ALA 111.A O no hydrogen 3.335 N/A TYR 103.A N HIS 60.A ND1 no hydrogen 3.022 N/A ALA 104.A N TYR 109.A O no hydrogen 2.990 N/A SER 106.A OG ASP 152.A OD1 no hydrogen 2.567 N/A SER 106.A OG ASP 152.A OD2 no hydrogen 3.002 N/A GLY 107.A N ALA 104.A O no hydrogen 2.922 N/A ASN 108.A N SER 106.A OG no hydrogen 3.429 N/A ASN 108.A ND2 ASP 152.A OD2 no hydrogen 3.398 N/A VAL 110.A N TYR 122.A O no hydrogen 2.927 N/A ALA 111.A N ALA 102.A O no hydrogen 2.816 N/A CYS 112.A N SER 120.A O no hydrogen 2.886 N/A LEU 115.A N TRP 97.A O no hydrogen 3.221 N/A ASN 117.A N GLY 114.A O no hydrogen 3.310 N/A ILE 118.A N ASP 116.A OD1 no hydrogen 3.435 N/A CYS 119.A N LEU 137.A O no hydrogen 3.266 N/A CYS 119.A SG CYS 112.A O no hydrogen 3.679 N/A SER 120.A OG GLU 136.A OE1 no hydrogen 3.031 N/A ILE 121.A N ARG 135.A O no hydrogen 2.896 N/A TYR 122.A N VAL 110.A O no hydrogen 2.900 N/A ASN 123.A N ARG 132.A O no hydrogen 3.312 N/A ASN 123.A ND2 LYS 125.A O no hydrogen 3.446 N/A LEU 124.A N ASN 108.A O no hydrogen 2.807 N/A LYS 125.A N ASN 123.A OD1 no hydrogen 3.282 N/A LYS 125.A NZ ASN 108.A OD1 no hydrogen 2.427 N/A THR 126.A N LEU 124.A O no hydrogen 3.000 N/A THR 126.A OG1 ASN 130.A O no hydrogen 2.586 N/A GLY 129.A N THR 126.A O no hydrogen 3.342 N/A SER 134.A N ILE 121.A O no hydrogen 2.786 N/A ARG 135.A N ILE 121.A O no hydrogen 2.933 N/A ARG 135.A NE ILE 169.A O no hydrogen 2.880 N/A ARG 135.A NE GLU 170.A O no hydrogen 3.452 N/A ARG 135.A NH2 GLU 170.A O no hydrogen 3.279 N/A HIS 140.A NE2 THR 157.A OG1 no hydrogen 3.083 N/A THR 141.A N ASP 161.A OD2 no hydrogen 3.317 N/A THR 141.A OG1 ASP 161.A OD2 no hydrogen 3.019 N/A TYR 143.A OH ASP 184.A OD2 no hydrogen 2.786 N/A LEU 144.A N GLY 114.A O no hydrogen 2.999 N/A SER 145.A N SER 158.A O no hydrogen 2.904 N/A SER 145.A OG SER 158.A O no hydrogen 3.289 N/A SER 145.A OG SER 158.A OG no hydrogen 2.797 N/A SER 145.A OG VAL 185.A O no hydrogen 2.364 N/A CYS 146.A N SER 158.A O no hydrogen 3.509 N/A CYS 146.A SG LEU 188.A O no hydrogen 3.660 N/A CYS 147.A SG THR 100.A OG1 no hydrogen 3.584 N/A ARG 148.A N VAL 156.A O no hydrogen 2.884 N/A ARG 148.A NH1 CYS 101.A O no hydrogen 3.386 N/A ARG 148.A NH1 CYS 147.A O no hydrogen 2.425 N/A LEU 150.A N GLN 154.A O no hydrogen 3.074 N/A ASP 151.A N GLN 154.A O no hydrogen 3.267 N/A ASN 153.A N ASP 151.A OD1 no hydrogen 3.257 N/A GLN 154.A N ASP 151.A OD1 no hydrogen 2.598 N/A ILE 155.A N TRP 167.A O no hydrogen 2.950 N/A VAL 156.A N ARG 148.A O no hydrogen 2.948 N/A THR 157.A N ALA 165.A O no hydrogen 2.891 N/A THR 157.A OG1 HIS 140.A NE2 no hydrogen 3.083 N/A THR 157.A OG1 ALA 165.A O no hydrogen 3.321 N/A SER 158.A N CYS 146.A O no hydrogen 2.891 N/A SER 158.A OG SER 145.A OG no hydrogen 2.797 N/A SER 158.A OG CYS 146.A O no hydrogen 3.474 N/A SER 159.A N THR 163.A O no hydrogen 3.329 N/A SER 159.A OG TYR 143.A O no hydrogen 3.357 N/A SER 159.A OG ASP 161.A OD1 no hydrogen 2.937 N/A GLY 160.A N TYR 143.A O no hydrogen 2.722 N/A ASP 161.A N SER 159.A OG no hydrogen 3.245 N/A THR 162.A OG1 ASP 161.A O no hydrogen 2.470 N/A THR 163.A N ASP 161.A OD1 no hydrogen 3.361 N/A THR 163.A OG1 ASP 161.A OD1 no hydrogen 2.789 N/A THR 163.A OG1 ASP 161.A OD2 no hydrogen 3.179 N/A CYS 164.A N PHE 178.A O no hydrogen 2.919 N/A ALA 165.A N THR 157.A O no hydrogen 2.906 N/A LEU 166.A N THR 176.A O no hydrogen 2.865 N/A TRP 167.A N ILE 155.A O no hydrogen 2.855 N/A ASP 168.A N GLN 173.A O no hydrogen 3.406 N/A ILE 169.A N ASN 153.A O no hydrogen 2.639 N/A THR 171.A N ASP 168.A OD2 no hydrogen 3.034 N/A THR 171.A OG1 ASP 168.A O no hydrogen 3.484 N/A THR 171.A OG1 ASP 168.A OD2 no hydrogen 3.127 N/A GLY 172.A N ASP 168.A O no hydrogen 2.772 N/A THR 176.A N LEU 166.A O no hydrogen 2.959 N/A THR 177.A OG1 GLN 174.A OE1 no hydrogen 3.049 N/A PHE 178.A N CYS 164.A O no hydrogen 2.869 N/A HIS 181.A NE2 SER 199.A O no hydrogen 3.154 N/A HIS 181.A NE2 SER 199.A OG no hydrogen 3.026 N/A THR 182.A OG1 ASP 203.A OD2 no hydrogen 3.286 N/A MET 186.A N GLY 200.A O no hydrogen 2.905 N/A SER 187.A OG ASN 228.A O no hydrogen 3.349 N/A SER 189.A N VAL 198.A O no hydrogen 3.022 N/A ALA 191.A N LEU 196.A O no hydrogen 3.154 N/A THR 194.A N ALA 191.A O no hydrogen 2.934 N/A THR 194.A OG1 ASP 193.A O no hydrogen 2.456 N/A ARG 195.A N ASP 193.A OD1 no hydrogen 3.398 N/A PHE 197.A N TRP 209.A O no hydrogen 2.942 N/A VAL 198.A N SER 189.A O no hydrogen 3.281 N/A SER 199.A N LYS 207.A O no hydrogen 2.900 N/A SER 199.A OG HIS 181.A NE2 no hydrogen 3.026 N/A GLY 200.A N SER 187.A O no hydrogen 3.110 N/A CYS 202.A N ASP 184.A O no hydrogen 2.892 N/A CYS 202.A SG ASP 184.A O no hydrogen 3.440 N/A SER 205.A OG ASP 203.A OD1 no hydrogen 3.054 N/A SER 205.A OG ASP 203.A OD2 no hydrogen 2.743 N/A ALA 206.A N PHE 220.A O no hydrogen 2.913 N/A LYS 207.A N SER 199.A O no hydrogen 2.911 N/A LEU 208.A N GLN 218.A O no hydrogen 2.916 N/A TRP 209.A N PHE 197.A O no hydrogen 2.878 N/A TRP 209.A NE1 SER 199.A OG no hydrogen 2.661 N/A ASP 210.A N MET 215.A O no hydrogen 3.269 N/A VAL 211.A N ARG 195.A O no hydrogen 3.046 N/A ARG 212.A N ASP 210.A OD1 no hydrogen 3.342 N/A ARG 212.A NH2 THR 194.A O no hydrogen 3.094 N/A GLY 214.A N ASP 210.A O no hydrogen 2.756 N/A CYS 216.A SG LEU 208.A O no hydrogen 3.789 N/A CYS 216.A SG GLN 218.A O no hydrogen 3.547 N/A CYS 216.A SG THR 219.A OG1 no hydrogen 3.678 N/A ARG 217.A N LEU 208.A O no hydrogen 2.684 N/A ARG 217.A NE ASP 210.A OD2 no hydrogen 3.133 N/A ARG 217.A NH2 ASP 210.A OD2 no hydrogen 2.797 N/A GLN 218.A NE2 LEU 253.A O no hydrogen 2.479 N/A PHE 220.A N ALA 206.A O no hydrogen 2.879 N/A HIS 223.A NE2 THR 241.A O no hydrogen 2.865 N/A HIS 223.A NE2 THR 241.A OG1 no hydrogen 2.760 N/A GLU 224.A N ASP 245.A OD2 no hydrogen 3.176 N/A ASP 226.A N SER 225.A OG no hydrogen 2.741 N/A ILE 227.A N ALA 201.A O no hydrogen 3.367 N/A ASN 228.A N GLY 242.A O no hydrogen 2.924 N/A ASN 228.A ND2 ASP 244.A OD1 no hydrogen 2.851 N/A ASN 228.A ND2 ILE 271.A O no hydrogen 2.813 N/A ALA 229.A N GLY 242.A O no hydrogen 3.369 N/A CYS 231.A N ALA 240.A O no hydrogen 3.157 N/A CYS 231.A SG PHE 232.A O no hydrogen 3.364 N/A PHE 232.A N SER 189.A OG no hydrogen 3.188 N/A PHE 233.A N ALA 238.A O no hydrogen 2.555 N/A ASN 237.A N ASN 235.A O no hydrogen 2.837 N/A ASN 237.A ND2 ASN 235.A OD1 no hydrogen 3.495 N/A PHE 239.A N PHE 251.A O no hydrogen 2.904 N/A ALA 240.A N CYS 231.A O no hydrogen 2.898 N/A THR 241.A N ARG 249.A O no hydrogen 2.899 N/A THR 241.A OG1 HIS 223.A NE2 no hydrogen 2.760 N/A THR 241.A OG1 ARG 249.A O no hydrogen 3.405 N/A GLY 242.A N ALA 229.A O no hydrogen 3.296 N/A SER 243.A N THR 247.A O no hydrogen 2.977 N/A SER 243.A OG ASP 226.A O no hydrogen 2.914 N/A SER 243.A OG ASP 245.A OD1 no hydrogen 3.048 N/A ASP 244.A N ASP 226.A O no hydrogen 2.936 N/A ASP 245.A N SER 243.A OG no hydrogen 3.268 N/A THR 247.A N ASP 245.A OD1 no hydrogen 3.279 N/A THR 247.A OG1 ASP 245.A OD1 no hydrogen 2.599 N/A THR 247.A OG1 ASP 245.A OD2 no hydrogen 3.060 N/A CYS 248.A N TYR 262.A O no hydrogen 2.945 N/A ARG 249.A N THR 241.A O no hydrogen 2.867 N/A ARG 249.A NE HIS 223.A ND1 no hydrogen 3.054 N/A ARG 249.A NH1 GLU 258.A OE1 no hydrogen 2.793 N/A ARG 249.A NH2 ASP 245.A OD2 no hydrogen 3.565 N/A LEU 250.A N MET 260.A O no hydrogen 2.924 N/A PHE 251.A N PHE 239.A O no hydrogen 2.897 N/A LEU 253.A N ASN 237.A O no hydrogen 3.001 N/A ARG 254.A N ASP 252.A OD1 no hydrogen 2.774 N/A ALA 255.A N ASP 252.A OD1 no hydrogen 3.379 N/A ASP 256.A N ASP 252.A O no hydrogen 2.742 N/A LEU 259.A N LEU 250.A O no hydrogen 2.800 N/A THR 261.A OG1 GLU 258.A OE1 no hydrogen 2.796 N/A TYR 262.A N CYS 248.A O no hydrogen 2.843 N/A TYR 262.A OH ALA 297.A O no hydrogen 2.825 N/A ASN 266.A N HIS 264.A ND1 no hydrogen 3.064 N/A ILE 267.A N HIS 264.A O no hydrogen 3.210 N/A ILE 271.A N SER 243.A O no hydrogen 3.060 N/A THR 272.A N GLY 286.A O no hydrogen 2.894 N/A THR 272.A OG1 GLY 286.A O no hydrogen 3.413 N/A THR 272.A OG1 VAL 313.A O no hydrogen 2.496 N/A SER 275.A N LEU 284.A O no hydrogen 2.865 N/A SER 275.A OG PHE 276.A O no hydrogen 3.522 N/A SER 277.A N LEU 282.A O no hydrogen 3.062 N/A LYS 278.A NZ ASP 320.A O no hydrogen 3.283 N/A GLY 280.A N SER 277.A O no hydrogen 3.264 N/A GLY 280.A N SER 277.A OG no hydrogen 3.146 N/A ARG 281.A NE ASP 296.A OD1 no hydrogen 2.603 N/A ARG 281.A NH2 ASP 36.A O no hydrogen 3.332 N/A ARG 281.A NH2 ASP 296.A OD2 no hydrogen 3.112 N/A LEU 283.A N TRP 295.A O no hydrogen 2.920 N/A LEU 284.A N SER 275.A O no hydrogen 2.886 N/A ALA 285.A N ASN 293.A O no hydrogen 2.909 N/A GLY 286.A N SER 273.A O no hydrogen 2.725 N/A TYR 287.A N ASN 291.A O no hydrogen 3.033 N/A ASP 288.A N GLY 270.A O no hydrogen 3.137 N/A ASN 291.A N ASP 289.A OD1 no hydrogen 3.205 N/A CYS 292.A N LEU 306.A O no hydrogen 2.906 N/A CYS 292.A SG ALA 285.A O no hydrogen 3.395 N/A ASN 293.A N ALA 285.A O no hydrogen 2.903 N/A VAL 294.A N GLY 304.A O no hydrogen 2.875 N/A TRP 295.A N LEU 283.A O no hydrogen 2.865 N/A TRP 295.A NE1 TYR 287.A OH no hydrogen 2.870 N/A ASP 296.A N ASP 301.A O no hydrogen 2.624 N/A ALA 297.A N ARG 281.A O no hydrogen 2.810 N/A LEU 298.A N ASP 296.A OD1 no hydrogen 3.405 N/A LYS 299.A N ASP 296.A O no hydrogen 3.328 N/A LYS 299.A NZ THR 32.A O no hydrogen 3.167 N/A LYS 299.A NZ ILE 35.A O no hydrogen 3.052 N/A ALA 300.A N ASP 296.A O no hydrogen 2.892 N/A GLY 304.A N VAL 294.A O no hydrogen 2.937 N/A LEU 306.A N CYS 292.A O no hydrogen 2.880 N/A HIS 309.A NE2 THR 327.A O no hydrogen 3.037 N/A HIS 309.A NE2 THR 327.A OG1 no hydrogen 2.714 N/A ARG 312.A N ASN 311.A OD1 no hydrogen 2.764 N/A SER 314.A N GLY 328.A O no hydrogen 2.855 N/A SER 314.A OG ILE 56.A O no hydrogen 2.344 N/A SER 314.A OG TYR 57.A O no hydrogen 3.006 N/A SER 314.A OG GLY 328.A O no hydrogen 3.404 N/A CYS 315.A N GLY 328.A O no hydrogen 3.106 N/A CYS 315.A SG SER 314.A OG no hydrogen 3.651 N/A GLY 317.A N ALA 326.A O no hydrogen 2.899 N/A THR 319.A N ALA 324.A O no hydrogen 3.331 N/A THR 319.A OG1 ASP 321.A OD1 no hydrogen 2.902 N/A THR 319.A OG1 ALA 324.A O no hydrogen 3.366 N/A ASP 321.A N SER 65.A OG no hydrogen 3.420 N/A GLY 322.A N THR 319.A O no hydrogen 3.052 N/A MET 323.A N ASP 321.A OD1 no hydrogen 3.347 N/A VAL 325.A N TRP 337.A O no hydrogen 2.935 N/A ALA 326.A N GLY 317.A O no hydrogen 2.894 N/A THR 327.A N LYS 335.A O no hydrogen 2.866 N/A THR 327.A OG1 HIS 309.A NE2 no hydrogen 2.714 N/A GLY 328.A N CYS 315.A O no hydrogen 2.949 N/A SER 329.A OG ARG 312.A O no hydrogen 2.692 N/A SER 329.A OG ASP 331.A OD1 no hydrogen 3.323 N/A TRP 330.A N ARG 312.A O no hydrogen 2.514 N/A LEU 334.A N LEU 49.A O no hydrogen 2.925 N/A LYS 335.A N THR 327.A O no hydrogen 2.928 N/A ILE 336.A N ARG 47.A O no hydrogen 2.874 N/A TRP 337.A N VAL 325.A O no hydrogen 2.866 N/A TRP 337.A NE1 THR 327.A OG1 no hydrogen 2.937 N/A ASN 338.A N ARG 44.A O no hydrogen 3.457 N/A