Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8e4j_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 3.A NZ GLU 286.A OE1 no hydrogen 3.276 N/A PHE 6.A N SER 111.A OG no hydrogen 2.783 N/A SER 8.A OG GLU 12.A OE2 no hydrogen 2.557 N/A VAL 11.A N SER 8.A O no hydrogen 3.022 N/A GLU 12.A N SER 8.A O no hydrogen 2.899 N/A GLY 13.A N GLY 9.A O no hydrogen 3.350 N/A CYS 14.A N VAL 11.A O no hydrogen 2.864 N/A CYS 14.A SG LYS 10.A O no hydrogen 3.605 N/A MET 15.A N GLU 12.A O no hydrogen 3.366 N/A VAL 16.A N GLY 27.A O no hydrogen 2.912 N/A GLN 17.A N GLN 67.A O no hydrogen 2.916 N/A VAL 18.A N LEU 25.A O no hydrogen 2.965 N/A THR 19.A N LEU 65.A O no hydrogen 2.790 N/A THR 19.A OG1 THR 24.A OG1 no hydrogen 3.238 N/A CYS 20.A N THR 23.A O no hydrogen 2.877 N/A CYS 20.A SG ASN 63.A O no hydrogen 3.694 N/A THR 23.A N CYS 20.A O no hydrogen 2.985 N/A THR 23.A OG1 CYS 42.A O no hydrogen 3.117 N/A THR 24.A OG1 THR 19.A OG1 no hydrogen 3.238 N/A LEU 25.A N VAL 18.A O no hydrogen 3.008 N/A ASN 26.A N CYS 143.A O.A no hydrogen 2.964 N/A ASN 26.A N CYS 143.A O.B no hydrogen 2.953 N/A ASN 26.A ND2 CYS 115.A O no hydrogen 3.119 N/A ASN 26.A ND2 GLY 141.A O no hydrogen 2.982 N/A ASN 26.A ND2 CYS 143.A O.A no hydrogen 2.961 N/A ASN 26.A ND2 CYS 143.A O.B no hydrogen 2.989 N/A GLY 27.A N VAL 16.A O no hydrogen 2.810 N/A LEU 28.A N TYR 35.A O no hydrogen 2.842 N/A TRP 29.A N CYS 14.A O no hydrogen 2.754 N/A LEU 30.A N VAL 33.A O no hydrogen 2.986 N/A ASP 31.A N THR 96.A OG1 no hydrogen 2.902 N/A VAL 33.A N LEU 30.A O no hydrogen 3.112 N/A VAL 34.A N LEU 87.A O no hydrogen 2.663 N/A TYR 35.A N LEU 28.A O no hydrogen 2.790 N/A CYS 36.A N LEU 85.A O no hydrogen 3.102 N/A CYS 36.A SG PRO 37.A O no hydrogen 3.861 N/A ARG 38.A N CYS 83.A O no hydrogen 3.015 N/A ARG 38.A NE ASP 185.A OD2 no hydrogen 2.673 N/A ARG 38.A NH2 ASP 185.A OD1 no hydrogen 3.047 N/A ARG 38.A NH2 ASP 185.A OD2 no hydrogen 3.465 N/A VAL 40.A N PRO 37.A O no hydrogen 3.183 N/A ILE 41.A N ARG 38.A O no hydrogen 3.116 N/A CYS 42.A N ALA 39.A O no hydrogen 3.073 N/A THR 43.A N ASP 46.A OD2 no hydrogen 2.910 N/A THR 43.A OG1 ASP 46.A OD2 no hydrogen 3.078 N/A ASP 46.A N THR 43.A OG1 no hydrogen 3.227 N/A MET 47.A N THR 43.A O no hydrogen 3.196 N/A LEU 48.A N GLU 45.A O no hydrogen 3.380 N/A ASN 49.A N ASP 46.A O no hydrogen 3.015 N/A TYR 52.A OH ASP 185.A O no hydrogen 2.655 N/A LEU 55.A N ASN 51.A O no hydrogen 3.084 N/A LEU 56.A N TYR 52.A O no hydrogen 3.002 N/A ILE 57.A N GLU 53.A O no hydrogen 3.245 N/A ARG 58.A N ASP 54.A O no hydrogen 3.335 N/A LYS 59.A N LEU 56.A O no hydrogen 3.064 N/A LYS 59.A NZ ILE 41.A O no hydrogen 3.047 N/A SER 60.A N ASN 63.A OD1 no hydrogen 3.047 N/A SER 60.A OG ASN 63.A OD1 no hydrogen 3.354 N/A ASN 61.A ND2 ILE 76.A O no hydrogen 2.618 N/A ASN 63.A N SER 60.A O no hydrogen 2.908 N/A PHE 64.A N ASN 61.A O no hydrogen 2.925 N/A LEU 65.A N THR 19.A O no hydrogen 2.895 N/A GLN 67.A N GLN 17.A O no hydrogen 2.905 N/A ALA 68.A N VAL 71.A O no hydrogen 2.837 N/A VAL 71.A N ALA 68.A O no hydrogen 3.170 N/A GLN 72.A NE2 GLN 67.A OE1 no hydrogen 3.649 N/A LEU 73.A N VAL 66.A O no hydrogen 2.845 N/A ARG 74.A N ASP 90.A OD1 no hydrogen 3.364 N/A ARG 74.A NE ASP 90.A OD2 no hydrogen 3.125 N/A ILE 76.A N LYS 88.A O no hydrogen 2.777 N/A GLY 77.A N LYS 88.A O no hydrogen 3.505 N/A HIS 78.A ND1 ASN 61.A OD1 no hydrogen 3.023 N/A SER 79.A N LYS 86.A O no hydrogen 3.054 N/A GLN 81.A N VAL 84.A O no hydrogen 2.904 N/A ASN 82.A ND2 GLU 176.A O no hydrogen 2.869 N/A CYS 83.A N GLY 177.A O no hydrogen 2.966 N/A CYS 83.A SG ASP 185.A OD1 no hydrogen 3.821 N/A CYS 83.A SG ASP 185.A OD2 no hydrogen 3.559 N/A VAL 84.A N GLN 81.A O no hydrogen 3.018 N/A LEU 85.A N CYS 36.A O no hydrogen 2.768 N/A LYS 86.A N SER 79.A O no hydrogen 2.777 N/A LYS 86.A NZ GLN 81.A OE1 no hydrogen 3.328 N/A LEU 87.A N VAL 34.A O no hydrogen 2.802 N/A LYS 88.A N GLY 77.A O no hydrogen 3.005 N/A LYS 88.A NZ ASP 32.A OD1 no hydrogen 2.851 N/A LYS 88.A NZ ASP 32.A OD2 no hydrogen 3.066 N/A VAL 89.A N ASP 32.A O no hydrogen 2.987 N/A ASP 90.A N ARG 74.A O no hydrogen 3.067 N/A THR 91.A OG1 ASP 90.A OD1 no hydrogen 3.362 N/A ASN 93.A N ASP 31.A O no hydrogen 2.802 N/A ASN 93.A ND2 GLY 13.A O no hydrogen 3.156 N/A ASN 93.A ND2 TRP 29.A O no hydrogen 2.920 N/A LYS 95.A N ASN 93.A OD1 no hydrogen 2.973 N/A THR 96.A N ASN 93.A O no hydrogen 3.150 N/A THR 96.A OG1 ASN 93.A O no hydrogen 2.737 N/A TYR 99.A OH ASP 31.A OD2 no hydrogen 3.200 N/A LYS 100.A N VAL 155.A O no hydrogen 2.982 N/A VAL 102.A N PHE 157.A O no hydrogen 2.944 N/A ARG 103.A NH1 ASP 174.A OD2 no hydrogen 2.903 N/A ARG 103.A NH1 ASN 178.A O no hydrogen 3.224 N/A ARG 103.A NH1 PHE 179.A O no hydrogen 3.484 N/A ARG 103.A NH2 PHE 179.A O no hydrogen 3.009 N/A ILE 104.A N TYR 180.A OH no hydrogen 3.110 N/A GLN 105.A N GLN 108.A OE1 no hydrogen 2.584 N/A GLY 107.A N MET 128.A O.A no hydrogen 2.759 N/A GLY 107.A N MET 128.A O.B no hydrogen 2.763 N/A GLN 108.A N GLN 105.A O no hydrogen 3.107 N/A THR 109.A OG1 ASP 293.A OD1 no hydrogen 3.342 N/A THR 109.A OG1 ASP 293.A OD2 no hydrogen 2.698 N/A PHE 110.A N CYS 126.A O no hydrogen 2.950 N/A SER 111.A N PHE 148.A O no hydrogen 2.880 N/A SER 111.A OG GLN 125.A OE1 no hydrogen 2.639 N/A VAL 112.A N TYR 124.A O no hydrogen 2.778 N/A LEU 113.A N VAL 146.A O no hydrogen 3.095 N/A ALA 114.A N GLY 122.A O no hydrogen 2.783 N/A CYS 115.A N SER 145.A OG no hydrogen 2.933 N/A CYS 115.A SG LEU 113.A O no hydrogen 3.774 N/A TYR 116.A N SER 119.A O no hydrogen 3.012 N/A GLY 118.A N ASN 26.A OD1 no hydrogen 2.728 N/A SER 119.A N TYR 116.A O no hydrogen 2.900 N/A SER 121.A N ALA 114.A O no hydrogen 2.840 N/A GLY 122.A N ALA 114.A O no hydrogen 3.345 N/A TYR 124.A N VAL 112.A O no hydrogen 3.125 N/A TYR 124.A OH SER 137.A O no hydrogen 3.281 N/A CYS 126.A N PHE 110.A O no hydrogen 2.940 N/A CYS 126.A SG.A PHE 110.A O no hydrogen 3.974 N/A ALA 127.A N GLU 288.A OE1 no hydrogen 3.322 N/A MET 128.A N.A GLN 108.A O no hydrogen 3.055 N/A MET 128.A N.B GLN 108.A O no hydrogen 3.051 N/A ARG 129.A N THR 133.A O no hydrogen 2.935 N/A ARG 129.A NE ASP 195.A OD2 no hydrogen 2.727 N/A ARG 129.A NH1 ASP 287.A OD1 no hydrogen 3.035 N/A ARG 129.A NH1 ASP 287.A OD2 no hydrogen 3.422 N/A ARG 129.A NH1 GLU 288.A OE2 no hydrogen 3.029 N/A ARG 129.A NH2 ASP 195.A OD2 no hydrogen 3.406 N/A ARG 129.A NH2 THR 196.A O no hydrogen 3.054 N/A ARG 129.A NH2 ASP 287.A OD2 no hydrogen 2.891 N/A ASN 131.A N ASP 195.A OD1 no hydrogen 3.400 N/A ASN 131.A ND2 GLY 193.A O no hydrogen 3.051 N/A PHE 132.A N ARG 129.A O no hydrogen 2.838 N/A THR 133.A N ASN 131.A OD1 no hydrogen 3.220 N/A THR 133.A OG1 ASN 131.A OD1 no hydrogen 2.737 N/A ILE 134.A N.A HIS 170.A O no hydrogen 3.006 N/A ILE 134.A N.B HIS 170.A O no hydrogen 2.970 N/A SER 137.A N TYR 124.A OH no hydrogen 3.251 N/A LEU 139.A N TYR 116.A OH no hydrogen 2.945 N/A SER 142.A N LEU 139.A O no hydrogen 3.238 N/A SER 142.A OG.A LEU 139.A O no hydrogen 2.545 N/A SER 142.A OG.B SER 145.A OG no hydrogen 3.290 N/A CYS 143.A SG.A HIS 162.A O no hydrogen 3.431 N/A CYS 143.A SG.B HIS 161.A O no hydrogen 3.771 N/A CYS 143.A SG.B HIS 162.A O no hydrogen 3.626 N/A GLY 144.A N HIS 161.A O no hydrogen 2.875 N/A SER 145.A N SER 142.A O no hydrogen 3.117 N/A SER 145.A OG SER 142.A O no hydrogen 2.837 N/A SER 145.A OG SER 142.A OG.B no hydrogen 3.290 N/A GLY 147.A N TYR 159.A O no hydrogen 2.834 N/A PHE 148.A N SER 111.A O no hydrogen 2.741 N/A ASN 149.A N SER 156.A O no hydrogen 2.990 N/A ASN 149.A ND2 THR 109.A O no hydrogen 3.155 N/A ASP 151.A N CYS 154.A O no hydrogen 2.791 N/A CYS 154.A N ASP 151.A O no hydrogen 3.014 N/A CYS 154.A SG LYS 98.A O no hydrogen 3.967 N/A VAL 155.A N LYS 98.A O no hydrogen 2.877 N/A SER 156.A N ASN 149.A O no hydrogen 2.857 N/A SER 156.A OG ASP 151.A OD2 no hydrogen 3.367 N/A PHE 157.A N LYS 100.A O no hydrogen 2.917 N/A CYS 158.A N GLY 147.A O no hydrogen 3.035 N/A TYR 159.A OH HIS 161.A ND1 no hydrogen 3.236 N/A MET 160.A N THR 173.A O no hydrogen 2.824 N/A HIS 161.A N SER 145.A O no hydrogen 2.837 N/A HIS 161.A ND1 TYR 159.A OH no hydrogen 3.236 N/A HIS 162.A N ALA 171.A O no hydrogen 3.116 N/A HIS 162.A NE2 THR 173.A OG1 no hydrogen 3.089 N/A MET 163.A N ALA 171.A O no hydrogen 3.128 N/A LEU 165.A N VAL 169.A O no hydrogen 2.791 N/A GLY 168.A N LEU 165.A O no hydrogen 2.734 N/A HIS 170.A N ILE 134.A O.A no hydrogen 2.865 N/A HIS 170.A N ILE 134.A O.B no hydrogen 2.807 N/A ALA 171.A N MET 163.A O no hydrogen 2.967 N/A THR 173.A N MET 160.A O no hydrogen 3.009 N/A THR 173.A OG1 HIS 162.A NE2 no hydrogen 3.089 N/A THR 173.A OG1 ASP 174.A O no hydrogen 2.791 N/A ASP 174.A N ASN 178.A O no hydrogen 2.963 N/A GLU 176.A N ASP 174.A OD1 no hydrogen 3.030 N/A GLY 177.A N ASP 174.A O no hydrogen 3.137 N/A ASN 178.A N ASP 174.A OD1 no hydrogen 2.987 N/A TYR 180.A N GLY 172.A O no hydrogen 2.967 N/A TYR 180.A OH CYS 158.A O no hydrogen 2.579 N/A VAL 184.A N GLN 190.A OE1 no hydrogen 3.006 N/A GLN 187.A N MET 47.A O no hydrogen 2.729 N/A THR 188.A N ARG 186.A O no hydrogen 2.997 N/A GLN 190.A NE2 VAL 184.A O no hydrogen 2.977 N/A GLN 190.A NE2 THR 188.A O no hydrogen 3.610 N/A THR 196.A OG1 GLU 238.A OE2 no hydrogen 2.532 N/A THR 197.A N ASN 236.A O no hydrogen 3.067 N/A ILE 198.A N ASP 287.A OD2 no hydrogen 2.887 N/A THR 199.A OG1 GLU 238.A O no hydrogen 2.433 N/A ASN 201.A ND2 GLY 107.A O no hydrogen 3.039 N/A ASN 201.A ND2 ASP 287.A O no hydrogen 2.921 N/A VAL 202.A N ILE 198.A O no hydrogen 3.151 N/A LEU 203.A N THR 199.A O no hydrogen 3.015 N/A ALA 204.A N VAL 200.A O no hydrogen 3.047 N/A TRP 205.A N ASN 201.A O no hydrogen 2.982 N/A LEU 206.A N VAL 202.A O no hydrogen 2.888 N/A TYR 207.A N LEU 203.A O no hydrogen 2.993 N/A TYR 207.A OH ILE 257.A O no hydrogen 2.740 N/A ALA 208.A N ALA 204.A O no hydrogen 3.006 N/A ALA 209.A N TRP 205.A O no hydrogen 2.938 N/A VAL 210.A N LEU 206.A O no hydrogen 3.080 N/A ILE 211.A N TYR 207.A O no hydrogen 2.827 N/A ASN 212.A N ALA 208.A O no hydrogen 2.958 N/A ASN 212.A ND2 ALA 208.A O no hydrogen 2.786 N/A GLY 213.A N VAL 210.A O no hydrogen 2.881 N/A ASP 214.A N ALA 209.A O no hydrogen 2.792 N/A TRP 216.A NE1 THR 278.A O no hydrogen 2.863 N/A LEU 218.A N ARG 215.A O no hydrogen 3.113 N/A ASN 219.A ND2 ALA 264.A O no hydrogen 3.583 N/A PHE 221.A N ASN 219.A OD1 no hydrogen 3.128 N/A THR 222.A OG1 ASP 261.A OD1 no hydrogen 3.086 N/A THR 223.A OG1 THR 224.A O no hydrogen 3.264 N/A ASP 227.A N THR 224.A OG1 no hydrogen 3.014 N/A PHE 228.A N THR 224.A O no hydrogen 2.852 N/A ASN 229.A N LEU 225.A O no hydrogen 2.912 N/A ASN 229.A ND2 LEU 240.A O no hydrogen 2.973 N/A LEU 230.A N ASN 226.A O no hydrogen 3.080 N/A ALA 232.A N PHE 228.A O no hydrogen 2.907 N/A MET 233.A N ASN 229.A O no hydrogen 3.039 N/A LYS 234.A N LEU 230.A O no hydrogen 3.338 N/A TYR 235.A N VAL 231.A O no hydrogen 3.252 N/A TYR 235.A N ALA 232.A O no hydrogen 2.925 N/A ASN 236.A N MET 233.A O no hydrogen 3.286 N/A TYR 237.A N ALA 232.A O no hydrogen 2.983 N/A GLU 238.A N THR 197.A O no hydrogen 2.967 N/A LEU 240.A N ASN 229.A OD1 no hydrogen 2.845 N/A THR 241.A N HIS 244.A ND1 no hydrogen 3.086 N/A GLN 242.A NE2 ASP 246.A OD1 no hydrogen 3.477 N/A HIS 244.A N THR 241.A OG1 no hydrogen 3.165 N/A VAL 245.A N THR 241.A O no hydrogen 3.239 N/A ASP 246.A N GLN 242.A O no hydrogen 3.081 N/A ILE 247.A N ASP 243.A O no hydrogen 3.081 N/A LEU 248.A N HIS 244.A O no hydrogen 3.191 N/A LEU 248.A N VAL 245.A O no hydrogen 3.250 N/A GLY 249.A N ASP 246.A O no hydrogen 2.984 N/A SER 252.A N LEU 248.A O no hydrogen 2.925 N/A SER 252.A OG ILE 257.A O no hydrogen 2.699 N/A ALA 253.A N GLY 249.A O no hydrogen 2.713 N/A GLN 254.A N PRO 250.A O no hydrogen 3.029 N/A GLN 254.A NE2 CYS 298.A O no hydrogen 3.500 N/A THR 255.A N LEU 251.A O no hydrogen 3.181 N/A THR 255.A OG1 LEU 251.A O no hydrogen 2.793 N/A THR 255.A OG1 SER 252.A O no hydrogen 3.504 N/A GLY 256.A N SER 252.A O no hydrogen 2.989 N/A MET 262.A N ALA 258.A O no hydrogen 2.959 N/A CYS 263.A N VAL 259.A O no hydrogen 2.811 N/A CYS 263.A SG VAL 259.A O no hydrogen 3.489 N/A ALA 264.A N LEU 260.A O no hydrogen 3.235 N/A SER 265.A N ASP 261.A O no hydrogen 3.290 N/A SER 265.A OG PHE 217.A O no hydrogen 3.291 N/A LEU 266.A N MET 262.A O no hydrogen 2.956 N/A LYS 267.A N CYS 263.A O no hydrogen 2.800 N/A GLU 268.A N ALA 264.A O no hydrogen 3.293 N/A LEU 269.A N SER 265.A O no hydrogen 3.092 N/A LEU 270.A N LEU 266.A O no hydrogen 2.869 N/A GLN 271.A N LYS 267.A O no hydrogen 3.060 N/A GLN 271.A N GLU 268.A O no hydrogen 3.186 N/A ASN 272.A N GLU 268.A O no hydrogen 2.850 N/A ASN 272.A ND2 GLU 268.A OE1 no hydrogen 3.006 N/A GLY 273.A N LEU 269.A O no hydrogen 2.939 N/A ASN 275.A ND2 ASN 272.A O no hydrogen 3.083 N/A ARG 277.A N MET 274.A O no hydrogen 3.067 N/A ILE 279.A N SER 282.A O no hydrogen 2.932 N/A LEU 280.A N ASP 214.A OD2 no hydrogen 2.921 N/A SER 282.A N ILE 279.A O no hydrogen 2.871 N/A SER 282.A OG LEU 284.A O no hydrogen 2.745 N/A LEU 284.A N SER 282.A OG no hydrogen 3.120 N/A GLU 288.A N GLU 286.A OE1 no hydrogen 3.188 N/A THR 290.A N ASP 293.A OD2 no hydrogen 3.099 N/A ASP 293.A N THR 290.A OG1 no hydrogen 2.946 N/A VAL 294.A N THR 290.A O no hydrogen 3.046 N/A VAL 295.A N PRO 291.A O no hydrogen 2.929 N/A ARG 296.A N PHE 292.A O no hydrogen 2.819 N/A ARG 296.A NH2 ASP 293.A OD1 no hydrogen 2.559 N/A GLN 297.A N ASP 293.A O no hydrogen 3.172 N/A GLN 297.A NE2 ARG 2.A O no hydrogen 3.104 N/A CYS 298.A N VAL 295.A O no hydrogen 3.145 N/A SER 299.A OG VAL 295.A O no hydrogen 2.921 N/A