Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8ei4_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 1.A N GLU 244.A OE2 no hydrogen 3.062 N/A MET 2.A N GLU 362.A OE1 no hydrogen 3.381 N/A PHE 4.A N MET 2.A O no hydrogen 2.981 N/A LYS 7.A N GLY 3.A O no hydrogen 3.337 N/A LYS 7.A NZ TYR 239.A O no hydrogen 2.799 N/A LEU 8.A N PHE 4.A O no hydrogen 3.109 N/A ALA 9.A N ARG 5.A O no hydrogen 3.301 N/A HIS 10.A N TRP 6.A O no hydrogen 3.115 N/A PHE 11.A N LYS 7.A O no hydrogen 3.269 N/A ARG 12.A N LEU 8.A O no hydrogen 2.755 N/A ARG 12.A NH1 PHE 117.A O no hydrogen 3.515 N/A ARG 12.A NH2 PHE 117.A O no hydrogen 3.150 N/A TYR 13.A N ALA 9.A O no hydrogen 3.033 N/A LEU 14.A N HIS 10.A O no hydrogen 2.985 N/A CYS 15.A N PHE 11.A O no hydrogen 3.061 N/A CYS 15.A SG PHE 11.A O no hydrogen 3.395 N/A GLN 16.A N ARG 12.A O no hydrogen 2.978 N/A SER 17.A N TYR 13.A O no hydrogen 3.057 N/A SER 17.A OG TYR 13.A O no hydrogen 3.212 N/A SER 17.A OG LEU 14.A O no hydrogen 3.444 N/A ASN 18.A N LEU 14.A O no hydrogen 3.135 N/A ASN 18.A N CYS 15.A O no hydrogen 2.984 N/A ASN 18.A ND2 LEU 14.A O no hydrogen 2.569 N/A ALA 19.A N GLN 16.A O no hydrogen 3.415 N/A LEU 20.A N ARG 50.A O no hydrogen 3.145 N/A HIS 23.A N SER 22.A OG no hydrogen 2.783 N/A VAL 24.A N ARG 52.A O no hydrogen 2.975 N/A ILE 26.A N TYR 54.A O no hydrogen 2.767 N/A ASN 27.A N GLN 40.A OE1 no hydrogen 2.748 N/A SER 29.A N ASP 36.A OD2 no hydrogen 3.369 N/A GLN 31.A N GLN 31.A OE1 no hydrogen 3.048 N/A THR 32.A OG1 ASP 36.A OD2 no hydrogen 2.264 N/A ASP 36.A N THR 32.A O no hydrogen 3.154 N/A SER 37.A N LEU 33.A O no hydrogen 3.086 N/A SER 37.A OG LEU 33.A O no hydrogen 2.870 N/A PHE 38.A N PHE 34.A O no hydrogen 3.147 N/A GLN 39.A N GLU 35.A O no hydrogen 3.177 N/A GLN 39.A NE2 GLU 35.A OE2 no hydrogen 3.553 N/A GLN 40.A N ASP 36.A O no hydrogen 3.012 N/A ILE 41.A N SER 37.A O no hydrogen 2.884 N/A MET 42.A N PHE 38.A O no hydrogen 2.980 N/A ALA 43.A N GLN 39.A O no hydrogen 3.157 N/A LEU 44.A N ILE 41.A O no hydrogen 2.849 N/A LYS 45.A N ASP 48.A OD2 no hydrogen 3.127 N/A ASP 48.A N LYS 45.A O no hydrogen 2.912 N/A LEU 49.A N PRO 46.A O no hydrogen 3.037 N/A ARG 50.A N TYR 47.A O no hydrogen 3.148 N/A ARG 50.A NE VAL 231.A O no hydrogen 3.019 N/A ARG 50.A NH2 VAL 231.A O no hydrogen 2.826 N/A ARG 51.A N ASP 48.A O no hydrogen 3.248 N/A ARG 51.A NE ASP 48.A OD1 no hydrogen 3.158 N/A ARG 51.A NH1 PRO 21.A O no hydrogen 2.650 N/A ARG 51.A NH2 ASP 48.A OD1 no hydrogen 3.408 N/A ARG 52.A N SER 22.A O no hydrogen 3.210 N/A TYR 54.A N VAL 24.A O no hydrogen 2.994 N/A ILE 56.A N ILE 26.A O no hydrogen 3.135 N/A ARG 64.A NH1 GLY 60.A O no hydrogen 3.311 N/A GLU 65.A N GLY 61.A O no hydrogen 2.931 N/A TRP 66.A N LEU 62.A O no hydrogen 2.892 N/A TRP 66.A NE1 SER 37.A OG no hydrogen 3.024 N/A PHE 67.A N ALA 63.A O no hydrogen 2.939 N/A PHE 68.A N ARG 64.A O no hydrogen 3.018 N/A LEU 69.A N GLU 65.A O no hydrogen 3.209 N/A LEU 70.A N TRP 66.A O no hydrogen 2.921 N/A SER 71.A OG THR 124.A OG1 no hydrogen 2.432 N/A HIS 72.A N PHE 68.A O no hydrogen 3.199 N/A GLU 73.A N LEU 69.A O no hydrogen 3.137 N/A VAL 74.A N LEU 70.A O no hydrogen 3.001 N/A ASN 76.A N GLU 73.A O no hydrogen 3.293 N/A GLU 83.A N GLN 90.A O no hydrogen 2.807 N/A LYS 87.A NZ GLY 86.A O no hydrogen 3.526 N/A GLN 90.A N GLU 83.A O no hydrogen 3.191 N/A GLN 90.A NE2 TYR 84.A O no hydrogen 2.752 N/A ASN 92.A N LEU 81.A O no hydrogen 2.848 N/A ALA 94.A N ASN 92.A OD1 no hydrogen 2.682 N/A SER 95.A N ASN 92.A O no hydrogen 3.244 N/A SER 95.A OG ASN 92.A O no hydrogen 3.111 N/A ILE 97.A N ALA 94.A O no hydrogen 3.290 N/A ASN 98.A N SER 95.A O no hydrogen 3.071 N/A ASP 100.A N ASN 98.A OD1 no hydrogen 3.259 N/A HIS 101.A N ASN 98.A O no hydrogen 3.191 N/A SER 103.A N ASP 100.A O no hydrogen 2.841 N/A TYR 104.A N ASP 100.A O no hydrogen 3.138 N/A PHE 105.A N HIS 101.A O no hydrogen 2.896 N/A CYS 106.A N LEU 102.A O no hydrogen 3.205 N/A PHE 107.A N SER 103.A O no hydrogen 3.262 N/A ILE 108.A N TYR 104.A O no hydrogen 2.948 N/A GLY 109.A N PHE 105.A O no hydrogen 3.096 N/A ARG 110.A N CYS 106.A O no hydrogen 3.036 N/A ARG 110.A NH1 GLU 230.A OE1 no hydrogen 3.280 N/A PHE 111.A N PHE 107.A O no hydrogen 2.847 N/A ILE 112.A N ILE 108.A O no hydrogen 2.876 N/A ALA 113.A N GLY 109.A O no hydrogen 2.978 N/A MET 114.A N ARG 110.A O no hydrogen 2.981 N/A ALA 115.A N PHE 111.A O no hydrogen 3.146 N/A LEU 116.A N ILE 112.A O no hydrogen 3.262 N/A PHE 117.A N ALA 113.A O no hydrogen 2.893 N/A HIS 118.A N MET 114.A O no hydrogen 2.836 N/A HIS 118.A NE2 LEU 49.A O no hydrogen 2.733 N/A GLY 119.A N LEU 116.A O no hydrogen 3.223 N/A LYS 120.A N ALA 115.A O no hydrogen 2.864 N/A LYS 120.A NZ HIS 118.A O no hydrogen 2.393 N/A ILE 122.A N LEU 249.A O no hydrogen 3.050 N/A ASP 123.A N SER 71.A OG no hydrogen 3.133 N/A THR 124.A N SER 71.A OG no hydrogen 3.081 N/A THR 124.A OG1 SER 71.A O no hydrogen 3.281 N/A THR 124.A OG1 SER 71.A OG no hydrogen 2.432 N/A PHE 126.A N TYR 131.A OH no hydrogen 3.328 N/A TYR 131.A N SER 127.A O no hydrogen 3.112 N/A LYS 132.A N LEU 128.A O no hydrogen 2.911 N/A LYS 132.A NZ LYS 138.A O no hydrogen 3.022 N/A LYS 132.A NZ ASP 143.A OD2 no hydrogen 2.654 N/A LYS 132.A NZ GLU 365.A OE1 no hydrogen 2.832 N/A ARG 133.A N PRO 129.A O no hydrogen 3.094 N/A ARG 133.A NH1 ARG 133.A O no hydrogen 3.074 N/A MET 134.A N PHE 130.A O no hydrogen 3.074 N/A LEU 135.A N TYR 131.A O no hydrogen 3.127 N/A LEU 135.A N LYS 132.A O no hydrogen 2.999 N/A SER 136.A N ARG 133.A O no hydrogen 3.260 N/A LYS 137.A N LYS 132.A O no hydrogen 2.999 N/A LYS 137.A NZ PHE 240.A O no hydrogen 3.496 N/A THR 140.A N ASP 143.A OD2 no hydrogen 3.119 N/A THR 140.A OG1 ASP 143.A OD2 no hydrogen 3.224 N/A LYS 142.A NZ SER 335.A OG no hydrogen 3.016 N/A ASP 143.A N THR 140.A OG1 no hydrogen 3.239 N/A LEU 144.A N THR 140.A O no hydrogen 3.306 N/A GLU 145.A N ILE 141.A O no hydrogen 3.140 N/A SER 146.A N LYS 142.A O no hydrogen 3.262 N/A SER 146.A N ASP 143.A O no hydrogen 3.097 N/A SER 146.A OG LYS 142.A O no hydrogen 3.264 N/A SER 146.A OG THR 337.A OG1 no hydrogen 2.831 N/A ILE 147.A N ASP 143.A O no hydrogen 3.360 N/A ILE 147.A N LEU 144.A O no hydrogen 3.016 N/A ASP 148.A N LEU 144.A O no hydrogen 2.861 N/A PHE 151.A N ASP 148.A OD1 no hydrogen 3.284 N/A TYR 152.A N ASP 148.A O no hydrogen 2.753 N/A ASN 153.A N THR 149.A O no hydrogen 2.780 N/A SER 154.A OG GLU 150.A O no hydrogen 3.370 N/A LEU 155.A N PHE 151.A O no hydrogen 3.345 N/A ILE 156.A N TYR 152.A O no hydrogen 3.038 N/A TRP 157.A N ASN 153.A O no hydrogen 3.086 N/A ILE 158.A N SER 154.A O no hydrogen 3.124 N/A ARG 159.A N LEU 155.A O no hydrogen 3.049 N/A ARG 159.A N ILE 156.A O no hydrogen 2.952 N/A ASP 160.A N ILE 156.A O no hydrogen 3.359 N/A TYR 171.A OH GLU 169.A OE2 no hydrogen 2.626 N/A SER 173.A N TYR 171.A O no hydrogen 2.798 N/A VAL 174.A N HIS 185.A O no hydrogen 3.079 N/A MET 176.A N THR 183.A O no hydrogen 3.178 N/A LYS 181.A NZ ILE 178.A O no hydrogen 3.419 N/A THR 183.A N MET 176.A O no hydrogen 2.790 N/A SER 184.A OG ASP 175.A OD2 no hydrogen 3.050 N/A LEU 187.A N PHE 172.A O no hydrogen 2.973 N/A LYS 188.A NZ GLU 203.A OE1 no hydrogen 3.475 N/A GLY 191.A N LYS 188.A O no hydrogen 3.151 N/A SER 192.A OG ASN 193.A OD1 no hydrogen 3.127 N/A ASN 193.A N GLY 190.A O no hydrogen 3.244 N/A ILE 194.A N GLY 191.A O no hydrogen 3.296 N/A VAL 196.A N MET 170.A O no hydrogen 2.482 N/A THR 197.A N ASN 200.A OD1 no hydrogen 2.684 N/A THR 197.A OG1 GLU 199.A OE2 no hydrogen 3.553 N/A GLU 198.A N GLU 198.A OE1 no hydrogen 2.475 N/A ASN 200.A N THR 197.A O no hydrogen 2.700 N/A ASN 200.A ND2 LEU 195.A O no hydrogen 3.483 N/A LYS 201.A NZ ILE 158.A O no hydrogen 3.043 N/A LYS 201.A NZ ASN 161.A O no hydrogen 2.952 N/A TYR 204.A N ASN 200.A O no hydrogen 3.270 N/A ILE 205.A N LYS 201.A O no hydrogen 2.894 N/A GLY 206.A N ASP 202.A O no hydrogen 2.978 N/A LEU 207.A N GLU 203.A O no hydrogen 2.705 N/A MET 208.A N TYR 204.A O no hydrogen 2.677 N/A THR 209.A N ILE 205.A O no hydrogen 2.942 N/A THR 209.A OG1 ILE 205.A O no hydrogen 2.781 N/A GLU 210.A N GLY 206.A O no hydrogen 2.986 N/A TRP 211.A N LEU 207.A O no hydrogen 2.858 N/A ARG 212.A N MET 208.A O no hydrogen 3.072 N/A ARG 212.A N THR 209.A O no hydrogen 3.191 N/A ARG 212.A NE ASP 148.A OD2 no hydrogen 2.988 N/A ARG 212.A NH1 ARG 212.A O no hydrogen 2.672 N/A ARG 212.A NH2 ASP 148.A OD2 no hydrogen 3.067 N/A GLN 220.A N GLN 220.A OE1 no hydrogen 2.800 N/A GLN 220.A NE2 SER 95.A OG no hydrogen 2.933 N/A GLN 220.A NE2 GLY 216.A O no hydrogen 3.165 N/A THR 221.A N VAL 217.A O no hydrogen 2.853 N/A THR 221.A OG1 VAL 217.A O no hydrogen 2.662 N/A LYS 222.A N GLN 218.A O no hydrogen 2.775 N/A LYS 222.A NZ ASP 226.A OD2 no hydrogen 3.144 N/A ALA 223.A N GLU 219.A O no hydrogen 2.979 N/A PHE 224.A N GLN 220.A O no hydrogen 3.031 N/A LEU 225.A N THR 221.A O no hydrogen 3.009 N/A ASP 226.A N LYS 222.A O no hydrogen 2.993 N/A GLY 227.A N ALA 223.A O no hydrogen 3.031 N/A PHE 228.A N PHE 224.A O no hydrogen 2.944 N/A ASN 229.A N LEU 225.A O no hydrogen 2.867 N/A GLU 230.A N ASP 226.A O no hydrogen 3.258 N/A GLU 230.A N GLY 227.A O no hydrogen 3.156 N/A VAL 231.A N PHE 228.A O no hydrogen 2.867 N/A VAL 232.A N PHE 228.A O no hydrogen 3.042 N/A LEU 234.A N ASN 229.A OD1 no hydrogen 3.020 N/A TRP 236.A N PRO 233.A O no hydrogen 3.044 N/A LEU 237.A N LEU 234.A O no hydrogen 2.988 N/A PHE 240.A N LEU 237.A O no hydrogen 3.164 N/A ASP 241.A N GLU 244.A OE1 no hydrogen 2.880 N/A GLU 242.A N GLU 242.A OE1 no hydrogen 2.543 N/A LYS 243.A NZ GLU 365.A O no hydrogen 2.926 N/A GLU 244.A N ASP 241.A OD1 no hydrogen 2.795 N/A LEU 245.A N ASP 241.A O no hydrogen 2.978 N/A GLU 246.A N GLU 242.A O no hydrogen 3.003 N/A VAL 247.A N LYS 243.A O no hydrogen 3.312 N/A MET 248.A N GLU 244.A O no hydrogen 3.003 N/A LEU 249.A N LEU 245.A O no hydrogen 3.213 N/A CYS 250.A N GLU 246.A O no hydrogen 2.804 N/A CYS 250.A SG THR 124.A O no hydrogen 3.954 N/A CYS 250.A SG GLU 246.A O no hydrogen 3.251 N/A GLY 251.A N VAL 247.A O no hydrogen 2.690 N/A ASP 259.A N ASP 256.A OD1 no hydrogen 3.364 N/A TRP 260.A N ASP 256.A O no hydrogen 2.936 N/A GLN 261.A N LEU 257.A O no hydrogen 2.880 N/A ARG 262.A N ALA 258.A O no hydrogen 3.214 N/A ASN 263.A N TRP 260.A O no hydrogen 3.194 N/A ASN 263.A ND2 ASP 259.A O no hydrogen 2.883 N/A THR 264.A N GLN 261.A O no hydrogen 3.374 N/A THR 264.A OG1 TRP 260.A O no hydrogen 2.783 N/A VAL 265.A N PHE 321.A O no hydrogen 2.715 N/A ARG 267.A N ILE 323.A O no hydrogen 2.805 N/A ARG 267.A NE GLU 324.A OE2 no hydrogen 2.534 N/A ARG 267.A NH2 GLU 324.A OE2 no hydrogen 3.144 N/A TYR 269.A OH LEU 344.A O no hydrogen 2.844 N/A THR 270.A N SER 273.A OG no hydrogen 2.971 N/A SER 273.A N THR 270.A O no hydrogen 3.182 N/A SER 273.A OG THR 270.A O no hydrogen 3.292 N/A GLN 275.A NE2 TYR 347.A O no hydrogen 2.730 N/A ILE 276.A N SER 273.A O no hydrogen 3.001 N/A ILE 277.A N SER 273.A O no hydrogen 2.996 N/A TRP 278.A N LYS 274.A O no hydrogen 2.886 N/A PHE 279.A N GLN 275.A O no hydrogen 2.984 N/A TRP 280.A N ILE 276.A O no hydrogen 2.913 N/A TRP 280.A NE1 TYR 266.A OH no hydrogen 2.865 N/A GLN 281.A N ILE 277.A O no hydrogen 2.995 N/A GLN 281.A NE2 GLU 285.A OE1 no hydrogen 3.029 N/A PHE 282.A N TRP 278.A O no hydrogen 2.741 N/A VAL 283.A N PHE 279.A O no hydrogen 3.136 N/A LYS 284.A N TRP 280.A O no hydrogen 3.317 N/A LYS 284.A N GLN 281.A O no hydrogen 3.252 N/A GLU 285.A N PHE 282.A O no hydrogen 3.137 N/A THR 286.A N PHE 282.A O no hydrogen 3.291 N/A ARG 291.A N ASP 287.A O no hydrogen 3.384 N/A ARG 291.A NE VAL 283.A O no hydrogen 2.827 N/A ARG 291.A NH2 VAL 283.A O no hydrogen 2.736 N/A MET 292.A N ASN 288.A O no hydrogen 3.167 N/A ARG 293.A N GLU 289.A O no hydrogen 3.075 N/A ARG 293.A NE ILE 361.A O no hydrogen 3.016 N/A ARG 293.A NH1 ASP 241.A OD2 no hydrogen 3.532 N/A ARG 293.A NH2 ASP 241.A OD2 no hydrogen 2.826 N/A LEU 294.A N VAL 290.A O no hydrogen 2.890 N/A LEU 295.A N ARG 291.A O no hydrogen 2.945 N/A GLN 296.A N MET 292.A O no hydrogen 2.948 N/A GLN 296.A NE2 LYS 243.A O no hydrogen 3.036 N/A GLN 296.A NE2 GLU 246.A OE1 no hydrogen 2.713 N/A PHE 297.A N ARG 293.A O no hydrogen 2.994 N/A VAL 298.A N LEU 294.A O no hydrogen 3.039 N/A THR 299.A N LEU 295.A O no hydrogen 2.670 N/A THR 299.A OG1 LEU 295.A O no hydrogen 2.874 N/A GLY 300.A N GLN 296.A O no hydrogen 2.835 N/A THR 301.A N THR 299.A OG1 no hydrogen 3.341 N/A THR 301.A OG1 GLU 246.A OE2 no hydrogen 2.916 N/A CYS 302.A N GLU 246.A OE1 no hydrogen 3.135 N/A ARG 303.A N THR 301.A OG1 no hydrogen 2.996 N/A GLY 308.A N PRO 305.A O no hydrogen 3.290 N/A PHE 309.A N ASP 259.A OD2 no hydrogen 2.743 N/A GLU 311.A N GLY 308.A O no hydrogen 3.238 N/A LEU 312.A N PHE 309.A O no hydrogen 3.205 N/A GLY 314.A N GLY 317.A O no hydrogen 2.969 N/A SER 315.A N CYS 338.A O no hydrogen 2.981 N/A GLY 317.A N SER 315.A O no hydrogen 2.428 N/A GLN 319.A N LEU 312.A O no hydrogen 2.785 N/A LYS 320.A NZ ASN 263.A OD1 no hydrogen 2.806 N/A CYS 322.A N ASN 340.A O no hydrogen 2.969 N/A CYS 322.A SG VAL 265.A O no hydrogen 3.738 N/A CYS 322.A SG ILE 323.A O no hydrogen 4.027 N/A ILE 323.A N VAL 265.A O no hydrogen 3.003 N/A GLU 324.A N LEU 342.A O no hydrogen 2.941 N/A LYS 325.A N ARG 267.A O no hydrogen 3.314 N/A TRP 331.A N LYS 328.A O no hydrogen 2.775 N/A ARG 334.A N ASP 343.A O no hydrogen 3.363 N/A SER 335.A OG PHE 297.A O no hydrogen 2.444 N/A HIS 336.A N ARG 341.A O no hydrogen 3.035 N/A HIS 336.A ND1 GLU 145.A OE2 no hydrogen 2.765 N/A HIS 336.A NE2 ASP 343.A OD2 no hydrogen 2.791 N/A THR 337.A OG1 SER 146.A OG no hydrogen 2.831 N/A CYS 338.A SG GLU 145.A O no hydrogen 3.863 N/A PHE 339.A N HIS 336.A O no hydrogen 2.961 N/A ASN 340.A N THR 337.A O no hydrogen 3.453 N/A ASN 340.A ND2 MET 313.A O no hydrogen 3.150 N/A ASN 340.A ND2 GLN 319.A O no hydrogen 2.690 N/A ARG 341.A N HIS 336.A O no hydrogen 3.280 N/A LEU 342.A N CYS 322.A O no hydrogen 2.706 N/A ASP 343.A N ARG 334.A O no hydrogen 2.737 N/A LEU 344.A N GLU 324.A O no hydrogen 2.787 N/A TYR 347.A N PRO 345.A O no hydrogen 2.909 N/A TYR 347.A OH TRP 331.A O no hydrogen 2.921 N/A LYS 348.A N GLN 352.A OE1 no hydrogen 2.944 N/A TYR 350.A OH GLU 285.A OE2 no hydrogen 3.047 N/A GLN 352.A N SER 349.A OG no hydrogen 3.326 N/A GLN 352.A NE2 ASP 329.A OD1 no hydrogen 3.523 N/A LEU 353.A N SER 349.A O no hydrogen 3.138 N/A LYS 354.A N TYR 350.A O no hydrogen 2.814 N/A GLU 355.A N GLU 351.A O no hydrogen 2.902 N/A LYS 356.A N GLN 352.A O no hydrogen 2.980 N/A LYS 356.A NZ ASP 329.A O no hydrogen 3.313 N/A LYS 356.A NZ TRP 331.A O no hydrogen 2.960 N/A LEU 357.A N LEU 353.A O no hydrogen 2.953 N/A LEU 358.A N LYS 354.A O no hydrogen 3.192 N/A PHE 359.A N GLU 355.A O no hydrogen 3.156 N/A ALA 360.A N LYS 356.A O no hydrogen 3.028 N/A ILE 361.A N LEU 357.A O no hydrogen 2.706 N/A GLU 362.A N LEU 358.A O no hydrogen 3.064 N/A GLU 363.A N PHE 359.A O no hydrogen 2.878 N/A