Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8eua_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 3.A N VAL 19.A O no hydrogen 3.425 N/A VAL 5.A N GLN 17.A O no hydrogen 3.364 N/A PHE 6.A N LYS 51.A O no hydrogen 3.116 N/A THR 7.A N HIS 15.A O no hydrogen 3.218 N/A THR 7.A OG1 HIS 15.A O no hydrogen 3.552 N/A THR 8.A N PHE 53.A O no hydrogen 2.958 N/A THR 8.A OG1 ASN 13.A O no hydrogen 2.813 N/A ASP 10.A N THR 8.A OG1 no hydrogen 3.102 N/A ASN 11.A N THR 8.A OG1 no hydrogen 2.930 N/A ASN 11.A ND2 TYR 54.A OH no hydrogen 3.360 N/A ILE 12.A N ASP 10.A OD1 no hydrogen 2.956 N/A ASN 13.A N ASP 10.A OD1 no hydrogen 3.064 N/A ASN 13.A ND2 ASP 10.A OD2 no hydrogen 3.015 N/A GLN 17.A N VAL 5.A O no hydrogen 2.752 N/A GLN 17.A NE2 THR 16.A O no hydrogen 2.954 N/A VAL 19.A N ILE 3.A O no hydrogen 3.094 N/A MET 21.A N ARG 1.A O no hydrogen 3.341 N/A SER 22.A N ASP 20.A OD1 no hydrogen 3.016 N/A SER 22.A OG ASP 20.A OD1 no hydrogen 2.679 N/A MET 23.A N ASP 20.A OD1 no hydrogen 2.901 N/A THR 24.A N GLN 27.A OE1 no hydrogen 2.840 N/A THR 24.A OG1 THR 40.A O no hydrogen 3.495 N/A TYR 25.A N ILE 42.A O no hydrogen 3.263 N/A TYR 25.A OH HIS 48.A ND1 no hydrogen 2.932 N/A GLY 26.A N THR 40.A O no hydrogen 2.776 N/A GLN 27.A N THR 24.A O no hydrogen 3.327 N/A GLN 28.A NE2 ASP 20.A O no hydrogen 2.691 N/A GLN 28.A NE2 MET 23.A O no hydrogen 3.427 N/A GLN 28.A NE2 THR 24.A O no hydrogen 3.620 N/A PHE 29.A N TYR 25.A O no hydrogen 2.939 N/A THR 32.A N THR 40.A OG1 no hydrogen 3.314 N/A THR 32.A OG1 GLY 30.A O no hydrogen 2.907 N/A TYR 33.A N TYR 54.A O no hydrogen 2.841 N/A LEU 34.A N ALA 37.A O no hydrogen 2.783 N/A ALA 37.A N LEU 34.A O no hydrogen 2.715 N/A VAL 39.A N THR 32.A O no hydrogen 2.890 N/A THR 40.A N ASP 38.A OD1 no hydrogen 2.977 N/A THR 40.A OG1 ASP 38.A OD1 no hydrogen 2.501 N/A ILE 42.A N VAL 39.A O no hydrogen 3.271 N/A LYS 43.A NZ SER 22.A O no hydrogen 3.195 N/A HIS 48.A N HIS 45.A O no hydrogen 3.331 N/A HIS 48.A ND1 TYR 25.A OH no hydrogen 2.932 N/A GLU 49.A N ASN 46.A O no hydrogen 3.373 N/A GLY 50.A N LYS 4.A O no hydrogen 2.753 N/A LYS 51.A N HIS 48.A O no hydrogen 3.311 N/A PHE 53.A N PHE 6.A O no hydrogen 2.787 N/A TYR 54.A N TYR 33.A O no hydrogen 2.848 N/A VAL 55.A N THR 8.A O no hydrogen 2.901 N/A LEU 56.A N PRO 31.A O no hydrogen 3.405 N/A ARG 63.A N ASP 59.A O no hydrogen 3.145 N/A VAL 64.A N ASP 60.A O no hydrogen 2.994 N/A GLU 65.A N THR 61.A O no hydrogen 3.013 N/A ALA 66.A N LEU 62.A O no hydrogen 3.054 N/A PHE 67.A N ARG 63.A O no hydrogen 3.270 N/A GLU 68.A N VAL 64.A O no hydrogen 3.042 N/A TYR 69.A N GLU 65.A O no hydrogen 3.228 N/A TYR 70.A N ALA 66.A O no hydrogen 2.877 N/A TYR 70.A OH VAL 9.A O no hydrogen 2.817 N/A HIS 71.A N PHE 67.A O no hydrogen 2.577 N/A ASP 74.A N THR 72.A OG1 no hydrogen 3.252 N/A SER 76.A N ASP 74.A OD1 no hydrogen 2.714 N/A SER 76.A OG ASP 74.A OD1 no hydrogen 3.117 N/A SER 76.A OG ASP 74.A OD2 no hydrogen 3.301 N/A ARG 80.A N SER 76.A O no hydrogen 3.064 N/A ARG 80.A NE SER 76.A OG no hydrogen 3.063 N/A ARG 80.A NH1 ALA 151.A O no hydrogen 2.472 N/A ARG 80.A NH2 ASP 74.A OD2 no hydrogen 3.395 N/A TYR 81.A N PHE 77.A O no hydrogen 2.767 N/A MET 82.A N LEU 78.A O no hydrogen 3.014 N/A SER 83.A N GLY 79.A O no hydrogen 2.686 N/A SER 83.A OG GLY 79.A O no hydrogen 3.440 N/A ALA 84.A N ARG 80.A O no hydrogen 3.322 N/A LEU 85.A N TYR 81.A O no hydrogen 2.934 N/A ASN 86.A N MET 82.A O no hydrogen 3.137 N/A HIS 87.A N ALA 84.A O no hydrogen 2.660 N/A THR 88.A N ALA 84.A O no hydrogen 2.884 N/A THR 88.A OG1 ALA 84.A O no hydrogen 3.560 N/A THR 88.A OG1 LEU 85.A O no hydrogen 3.538 N/A THR 88.A OG1 ALA 143.A O no hydrogen 2.922 N/A LYS 89.A N LEU 85.A O no hydrogen 2.775 N/A LYS 89.A NZ ASP 35.A O no hydrogen 2.916 N/A LYS 89.A NZ ASN 86.A OD1 no hydrogen 3.083 N/A LYS 90.A N HIS 87.A O no hydrogen 2.734 N/A LYS 90.A NZ ASN 86.A O no hydrogen 3.283 N/A TRP 91.A N HIS 87.A O no hydrogen 3.371 N/A TYR 93.A OH THR 88.A O no hydrogen 3.002 N/A GLN 95.A NE2 THR 100.A OG1 no hydrogen 2.777 N/A VAL 96.A N LEU 99.A O no hydrogen 2.636 N/A THR 100.A N GLN 119.A OE1 no hydrogen 3.365 N/A THR 100.A OG1 ALA 137.A O no hydrogen 2.946 N/A SER 101.A N PRO 94.A O no hydrogen 3.056 N/A SER 101.A OG GLY 285.A O no hydrogen 2.643 N/A LYS 103.A N LYS 92.A O no hydrogen 2.808 N/A ASN 108.A ND2 LYS 103.A O no hydrogen 3.292 N/A CYS 109.A SG HIS 270.A ND1 no hydrogen 3.922 N/A ALA 112.A N ASN 108.A O no hydrogen 3.107 N/A THR 113.A N CYS 109.A O no hydrogen 3.067 N/A THR 113.A OG1 CYS 109.A O no hydrogen 3.181 N/A ALA 114.A N TYR 110.A O no hydrogen 2.918 N/A LEU 115.A N LEU 111.A O no hydrogen 2.669 N/A LEU 116.A N ALA 112.A O no hydrogen 2.888 N/A THR 117.A N THR 113.A O no hydrogen 2.850 N/A THR 117.A OG1 THR 113.A O no hydrogen 3.005 N/A LEU 118.A N LEU 115.A O no hydrogen 3.076 N/A GLN 119.A N LEU 116.A O no hydrogen 3.317 N/A GLN 119.A NE2 THR 100.A O no hydrogen 2.752 N/A GLN 119.A NE2 LEU 115.A O no hydrogen 3.313 N/A GLN 120.A N THR 117.A O no hydrogen 3.129 N/A GLN 120.A NE2 HIS 273.A NE2 no hydrogen 3.343 N/A LYS 124.A NZ PHE 125.A O no hydrogen 3.554 N/A PHE 125.A N GLN 131.A OE1 no hydrogen 2.573 N/A ASN 126.A N HIS 173.A O no hydrogen 2.914 N/A ALA 129.A N TYR 69.A O no hydrogen 2.810 N/A LEU 130.A N PRO 127.A O no hydrogen 2.860 N/A GLN 131.A N PRO 127.A O no hydrogen 3.072 N/A ASP 132.A N PRO 128.A O no hydrogen 3.005 N/A ALA 133.A N ALA 129.A O no hydrogen 3.127 N/A TYR 134.A N LEU 130.A O no hydrogen 2.791 N/A TYR 134.A OH LEU 118.A O no hydrogen 2.430 N/A TYR 135.A N GLN 131.A O no hydrogen 3.152 N/A ARG 136.A N ASP 132.A O no hydrogen 3.196 N/A ALA 137.A N ALA 133.A O no hydrogen 3.062 N/A ARG 138.A N TYR 134.A O no hydrogen 2.943 N/A ARG 138.A NH1 ARG 138.A O no hydrogen 2.845 N/A ALA 139.A N ARG 136.A O no hydrogen 3.025 N/A GLY 140.A N ALA 137.A O no hydrogen 2.707 N/A CYS 146.A N ALA 142.A O no hydrogen 3.159 N/A CYS 146.A SG ALA 142.A O no hydrogen 3.434 N/A ALA 147.A N ALA 143.A O no hydrogen 2.980 N/A LEU 148.A N ASN 144.A O no hydrogen 3.076 N/A ILE 149.A N PHE 145.A O no hydrogen 2.904 N/A LEU 150.A N CYS 146.A O no hydrogen 2.996 N/A ALA 151.A N ALA 147.A O no hydrogen 2.884 N/A TYR 152.A N LEU 148.A O no hydrogen 2.644 N/A TYR 152.A OH TYR 70.A O no hydrogen 2.732 N/A CYS 153.A N ILE 149.A O no hydrogen 2.954 N/A CYS 153.A N LEU 150.A O no hydrogen 3.015 N/A CYS 153.A SG ILE 149.A O no hydrogen 2.957 N/A ASN 154.A N ALA 151.A O no hydrogen 3.085 N/A LYS 155.A N LEU 150.A O no hydrogen 3.122 N/A THR 156.A OG1 GLU 159.A OE2 no hydrogen 2.715 N/A GLU 159.A N THR 156.A O no hydrogen 3.018 N/A VAL 163.A N TYR 271.A OH no hydrogen 3.008 N/A THR 166.A N ASP 162.A O no hydrogen 3.109 N/A THR 166.A OG1 ASP 162.A O no hydrogen 2.973 N/A MET 167.A N VAL 163.A O no hydrogen 2.841 N/A MET 167.A N ARG 164.A O no hydrogen 3.238 N/A SER 168.A N ARG 164.A O no hydrogen 3.143 N/A SER 168.A OG ARG 164.A O no hydrogen 2.765 N/A SER 168.A OG GLU 165.A O no hydrogen 2.682 N/A TYR 169.A N GLU 165.A O no hydrogen 3.211 N/A LEU 170.A N THR 166.A O no hydrogen 3.411 N/A PHE 171.A N MET 167.A O no hydrogen 2.715 N/A GLN 172.A N SER 168.A O no hydrogen 2.957 N/A HIS 173.A N LEU 170.A O no hydrogen 2.882 N/A HIS 173.A ND1 TYR 169.A O no hydrogen 3.095 N/A ALA 174.A N PHE 171.A O no hydrogen 3.028 N/A ASN 175.A N LYS 124.A O no hydrogen 2.912 N/A ASP 177.A N ASN 175.A OD1 no hydrogen 3.146 N/A CYS 179.A N LEU 176.A O no hydrogen 3.345 N/A LYS 180.A N GLU 236.A O no hydrogen 2.890 N/A LYS 180.A NZ GLN 234.A OE1 no hydrogen 3.399 N/A ARG 181.A N LEU 197.A O no hydrogen 2.700 N/A ARG 181.A NE GLN 235.A OE1 no hydrogen 2.700 N/A ARG 181.A NH1 MET 204.A O no hydrogen 2.830 N/A ARG 181.A NH2 GLN 235.A OE1 no hydrogen 3.153 N/A VAL 182.A N GLN 234.A O no hydrogen 2.946 N/A LEU 183.A N THR 195.A O no hydrogen 2.819 N/A ASN 184.A N TYR 231.A O no hydrogen 3.013 N/A VAL 185.A N GLN 193.A O no hydrogen 2.871 N/A VAL 186.A N THR 229.A O no hydrogen 2.862 N/A CYS 187.A SG GLN 227.A O no hydrogen 3.050 N/A CYS 190.A SG GLN 193.A OE1 no hydrogen 3.362 N/A CYS 190.A SG THR 223.A OG1 no hydrogen 2.351 N/A GLN 193.A N VAL 185.A O no hydrogen 2.874 N/A LEU 197.A N ARG 181.A O no hydrogen 2.773 N/A GLY 199.A N CYS 179.A O no hydrogen 3.157 N/A ALA 202.A N GLY 199.A O no hydrogen 2.909 N/A VAL 203.A N VAL 200.A O no hydrogen 3.086 N/A TYR 205.A N MET 241.A O no hydrogen 3.348 N/A GLY 207.A N SER 243.A O no hydrogen 2.787 N/A SER 210.A N THR 208.A OG1 no hydrogen 3.212 N/A GLN 213.A N SER 210.A OG no hydrogen 2.860 N/A GLN 213.A NE2 GLN 213.A O no hydrogen 3.227 N/A GLN 213.A NE2 GLY 217.A O no hydrogen 3.572 N/A PHE 214.A N SER 210.A O no hydrogen 3.207 N/A LYS 215.A N TYR 211.A O no hydrogen 3.256 N/A LYS 215.A N GLU 212.A O no hydrogen 3.004 N/A LYS 216.A N GLU 212.A O no hydrogen 3.166 N/A GLY 217.A N GLN 213.A O no hydrogen 2.807 N/A VAL 218.A N LYS 230.A O no hydrogen 2.989 N/A ILE 220.A N ALA 228.A O no hydrogen 3.005 N/A CYS 222.A SG LYS 226.A O no hydrogen 3.166 N/A THR 223.A OG1 GLN 193.A OE1 no hydrogen 2.319 N/A THR 229.A N VAL 186.A O no hydrogen 2.930 N/A LYS 230.A N VAL 218.A O no hydrogen 3.131 N/A TYR 231.A N ASN 184.A O no hydrogen 2.829 N/A LEU 232.A N PHE 214.A O no hydrogen 3.226 N/A GLN 234.A N VAL 182.A O no hydrogen 3.171 N/A GLN 235.A N TYR 308.A O no hydrogen 3.153 N/A GLN 235.A NE2 ALA 202.A O no hydrogen 2.893 N/A GLU 236.A N LYS 180.A O no hydrogen 2.873 N/A SER 237.A OG PHE 239.A O no hydrogen 2.713 N/A VAL 240.A N TYR 303.A O no hydrogen 3.089 N/A MET 241.A N VAL 203.A O no hydrogen 2.794 N/A MET 242.A N VAL 301.A O no hydrogen 2.955 N/A SER 243.A N TYR 205.A O no hydrogen 2.779 N/A SER 243.A OG THR 299.A O no hydrogen 3.542 N/A SER 243.A OG ASP 300.A OD1 no hydrogen 2.341 N/A ALA 244.A N THR 299.A O no hydrogen 2.815 N/A TYR 249.A N GLY 296.A O no hydrogen 2.904 N/A LEU 251.A N TYR 294.A O no hydrogen 2.596 N/A GLY 254.A N SER 276.A OG no hydrogen 2.933 N/A THR 255.A N LYS 252.A O no hydrogen 3.229 N/A THR 255.A OG1 LYS 252.A O no hydrogen 2.972 N/A THR 257.A N PHE 302.A O no hydrogen 2.877 N/A CYS 258.A N PHE 302.A O no hydrogen 3.453 N/A ALA 259.A N ILE 274.A O no hydrogen 2.643 N/A SER 260.A N ASP 300.A O no hydrogen 2.906 N/A SER 260.A OG ASP 300.A OD2 no hydrogen 3.215 N/A GLU 261.A N LYS 272.A O no hydrogen 2.664 N/A TYR 262.A N PRO 297.A O no hydrogen 2.834 N/A TYR 262.A OH ASN 265.A O no hydrogen 2.903 N/A THR 263.A N HIS 270.A O no hydrogen 3.236 N/A THR 263.A OG1 GLU 261.A OE1 no hydrogen 3.400 N/A CYS 268.A N ASN 265.A O no hydrogen 2.848 N/A HIS 270.A N THR 263.A O no hydrogen 2.987 N/A HIS 270.A NE2 ASP 284.A OD1 no hydrogen 2.846 N/A HIS 270.A NE2 ASP 284.A OD2 no hydrogen 3.195 N/A LYS 272.A N GLU 261.A O no hydrogen 2.947 N/A HIS 273.A N ILE 283.A O no hydrogen 2.969 N/A ILE 274.A N ALA 259.A O no hydrogen 2.920 N/A THR 275.A N TYR 281.A O no hydrogen 2.943 N/A THR 275.A OG1 GLN 120.A OE1 no hydrogen 2.969 N/A SER 276.A N THR 257.A O no hydrogen 3.137 N/A GLU 278.A N GLU 278.A OE1 no hydrogen 2.672 N/A THR 279.A OG1 SER 291.A O no hydrogen 3.005 N/A LEU 280.A N SER 291.A O no hydrogen 3.154 N/A TYR 281.A OH GLU 278.A OE2 no hydrogen 2.198 N/A CYS 282.A N THR 289.A O no hydrogen 2.591 N/A CYS 282.A SG HIS 273.A O no hydrogen 3.951 N/A ILE 283.A N HIS 273.A O no hydrogen 2.692 N/A ASP 284.A N LEU 287.A O no hydrogen 3.073 N/A LEU 287.A N ASP 284.A O no hydrogen 2.948 N/A SER 291.A OG GLU 293.A O no hydrogen 2.764 N/A TYR 294.A N LEU 251.A O no hydrogen 3.149 N/A GLY 296.A N TYR 249.A O no hydrogen 3.190 N/A THR 299.A N SER 260.A O no hydrogen 2.943 N/A THR 299.A OG1 ALA 244.A O no hydrogen 2.971 N/A THR 299.A OG1 ASP 300.A OD1 no hydrogen 3.472 N/A VAL 301.A N MET 242.A O no hydrogen 2.654 N/A PHE 302.A N CYS 258.A O no hydrogen 2.896 N/A TYR 303.A N VAL 240.A O no hydrogen 2.890 N/A TYR 303.A OH LEU 209.A O no hydrogen 2.543 N/A GLU 305.A N PRO 238.A O no hydrogen 3.319 N/A TYR 308.A N GLN 235.A O no hydrogen 3.074 N/A THR 310.A OG1 LEU 232.A O no hydrogen 3.298 N/A