Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 8f8e_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 2.A N GLU 291.A O no hydrogen 3.051 N/A ILE 4.A N LEU 289.A O no hydrogen 2.820 N/A SER 5.A N LEU 289.A O no hydrogen 3.464 N/A PHE 7.A N CYS 287.A O no hydrogen 2.810 N/A ARG 8.A NH1 ASP 284.A OD2 no hydrogen 3.469 N/A ARG 8.A NH2 ASP 284.A OD1 no hydrogen 2.995 N/A GLU 9.A N SER 15.A OG no hydrogen 3.133 N/A SER 15.A N ASP 284.A OD1 no hydrogen 2.788 N/A SER 15.A OG THR 285.A O no hydrogen 2.996 N/A GLY 16.A N GLU 9.A OE1 no hydrogen 2.669 N/A PHE 17.A N THR 285.A O no hydrogen 3.258 N/A THR 18.A N GLY 32.A O no hydrogen 2.876 N/A THR 18.A OG1 ILE 59.A O no hydrogen 2.615 N/A CYS 20.A N ASP 265.A OD2 no hydrogen 2.912 N/A CYS 20.A SG ALA 276.A O no hydrogen 3.800 N/A ALA 21.A N MET 30.A O no hydrogen 2.965 N/A SER 23.A N PHE 28.A O no hydrogen 2.865 N/A SER 23.A OG PHE 28.A O no hydrogen 3.109 N/A GLU 26.A N SER 23.A O no hydrogen 2.815 N/A PHE 28.A N SER 23.A OG no hydrogen 3.060 N/A LEU 29.A N TYR 41.A O no hydrogen 2.853 N/A MET 30.A N ALA 21.A O no hydrogen 2.731 N/A LEU 31.A N LYS 39.A O no hydrogen 2.811 N/A GLY 32.A N CYS 19.A O no hydrogen 3.051 N/A THR 33.A N GLN 37.A O no hydrogen 2.880 N/A THR 33.A OG1 THR 35.A OG1 no hydrogen 3.117 N/A CYS 34.A N GLY 16.A O no hydrogen 2.823 N/A CYS 34.A SG GLY 16.A O no hydrogen 3.757 N/A THR 35.A N THR 33.A OG1 no hydrogen 3.195 N/A THR 35.A OG1 THR 33.A OG1 no hydrogen 3.117 N/A GLY 36.A N THR 33.A O no hydrogen 3.094 N/A GLN 37.A N THR 33.A OG1 no hydrogen 3.158 N/A GLN 37.A NE2 SER 51.A OG no hydrogen 2.996 N/A LEU 38.A N TYR 52.A O no hydrogen 2.822 N/A LYS 39.A N LEU 31.A O no hydrogen 2.790 N/A LYS 39.A NZ GLU 48.A OE2 no hydrogen 3.407 N/A LYS 39.A NZ SER 51.A OG no hydrogen 2.468 N/A LEU 40.A N ALA 50.A O no hydrogen 2.887 N/A TYR 41.A N LEU 29.A O no hydrogen 2.890 N/A TYR 41.A OH ARG 8.A O no hydrogen 3.349 N/A ASN 42.A N GLN 47.A O no hydrogen 2.880 N/A ASN 42.A ND2 GLU 49.A OE2 no hydrogen 3.251 N/A VAL 43.A N ARG 27.A O no hydrogen 3.194 N/A SER 45.A N ASN 42.A OD1 no hydrogen 2.870 N/A GLY 46.A N ASN 42.A O no hydrogen 2.796 N/A GLN 47.A N SER 45.A OG no hydrogen 3.183 N/A GLU 49.A N LEU 40.A O no hydrogen 2.757 N/A TYR 52.A N LEU 38.A O no hydrogen 2.787 N/A CYS 54.A N GLY 36.A O no hydrogen 2.993 N/A CYS 54.A SG TYR 52.A O no hydrogen 4.030 N/A HIS 55.A N GLY 36.A O no hydrogen 2.972 N/A HIS 55.A ND1 PRO 80.A O no hydrogen 3.120 N/A HIS 55.A NE2 THR 73.A OG1 no hydrogen 2.747 N/A ASN 56.A ND2 SER 78.A OG no hydrogen 2.915 N/A SER 57.A OG TRP 77.A O no hydrogen 3.179 N/A ILE 59.A N THR 33.A O no hydrogen 2.991 N/A THR 60.A N SER 74.A O no hydrogen 2.762 N/A THR 60.A OG1 SER 74.A O no hydrogen 3.200 N/A GLU 63.A N LEU 72.A O no hydrogen 2.898 N/A SER 65.A N LEU 70.A O no hydrogen 2.862 N/A SER 65.A OG ASP 67.A OD1 no hydrogen 2.768 N/A SER 65.A OG LEU 70.A O no hydrogen 3.397 N/A ARG 66.A N GLN 110.A OE1 no hydrogen 2.779 N/A ARG 66.A NH1 LYS 107.A O no hydrogen 2.836 N/A ARG 66.A NH2 LYS 107.A O no hydrogen 2.901 N/A ARG 66.A NH2 HIS 108.A O no hydrogen 3.228 N/A GLY 68.A N SER 65.A O no hydrogen 3.270 N/A SER 69.A N ASP 67.A OD1 no hydrogen 3.013 N/A SER 69.A OG ASP 67.A OD1 no hydrogen 2.831 N/A SER 69.A OG ASP 67.A OD2 no hydrogen 3.431 N/A LEU 70.A N SER 65.A OG no hydrogen 3.076 N/A LEU 71.A N TRP 85.A O no hydrogen 2.879 N/A LEU 72.A N GLU 63.A O no hydrogen 2.867 N/A THR 73.A N ALA 83.A O no hydrogen 2.945 N/A THR 73.A OG1 HIS 55.A NE2 no hydrogen 2.747 N/A SER 74.A N HIS 61.A O no hydrogen 2.998 N/A SER 74.A OG SER 82.A OG no hydrogen 2.786 N/A ALA 75.A N LEU 81.A O no hydrogen 2.670 N/A THR 76.A N SER 57.A OG no hydrogen 3.135 N/A THR 76.A OG1 ALA 58.A O no hydrogen 2.883 N/A TRP 77.A N SER 57.A OG no hydrogen 3.078 N/A LEU 81.A N THR 98.A O no hydrogen 3.037 N/A SER 82.A N PHE 97.A O no hydrogen 3.371 N/A SER 82.A OG SER 74.A OG no hydrogen 2.786 N/A SER 82.A OG ASP 100.A O no hydrogen 2.692 N/A ALA 83.A N THR 73.A O no hydrogen 2.949 N/A LEU 84.A N HIS 95.A O no hydrogen 2.854 N/A TRP 85.A N LEU 71.A O no hydrogen 2.774 N/A TRP 85.A NE1 THR 73.A OG1 no hydrogen 2.820 N/A GLY 86.A N ASP 92.A O no hydrogen 2.862 N/A MET 87.A N SER 69.A O no hydrogen 2.842 N/A SER 89.A OG LYS 88.A O no hydrogen 2.667 N/A VAL 90.A N LYS 88.A O no hydrogen 2.886 N/A ASP 92.A N GLY 86.A O no hydrogen 3.453 N/A LYS 94.A N LEU 84.A O no hydrogen 2.778 N/A HIS 95.A N LEU 84.A O no hydrogen 3.306 N/A HIS 95.A NE2 GLN 127.A O no hydrogen 2.923 N/A PHE 97.A N SER 82.A O no hydrogen 2.892 N/A THR 98.A OG1.B GLU 99.A OE2 no hydrogen 3.483 N/A ASP 100.A N PHE 97.A O no hydrogen 3.286 N/A HIS 101.A N.A THR 116.A O no hydrogen 2.999 N/A HIS 101.A N.B THR 116.A O no hydrogen 2.953 N/A TYR 102.A OH GLU 104.A OE2 no hydrogen 2.620 N/A GLU 104.A N ILE 114.A O no hydrogen 2.922 N/A PHE 105.A N GLU 63.A OE1 no hydrogen 2.954 N/A SER 106.A N ARG 112.A O no hydrogen 2.962 N/A SER 106.A OG SER 109.A O no hydrogen 2.591 N/A SER 106.A OG ARG 112.A O no hydrogen 3.325 N/A LYS 107.A N ASP 155.A OD1 no hydrogen 2.687 N/A LYS 107.A NZ.A THR 150.A OG1 no hydrogen 3.104 N/A LYS 107.A NZ.A PHE 151.A O no hydrogen 2.740 N/A LYS 107.A NZ.B PHE 151.A O no hydrogen 2.927 N/A HIS 108.A N ASP 155.A OD1 no hydrogen 3.105 N/A HIS 108.A N ASP 155.A OD2 no hydrogen 3.051 N/A SER 109.A N ASP 155.A OD2 no hydrogen 3.026 N/A GLN 110.A NE2 SER 106.A O no hydrogen 3.316 N/A ARG 112.A N SER 106.A OG no hydrogen 3.183 N/A ARG 112.A NE ASP 111.A OD1 no hydrogen 3.500 N/A VAL 113.A N TYR 124.A O no hydrogen 2.928 N/A ILE 114.A N GLU 104.A O no hydrogen 2.764 N/A GLY 115.A N HIS 122.A O no hydrogen 2.745 N/A THR 116.A N TYR 102.A O no hydrogen 2.898 N/A LYS 117.A N ILE 120.A O no hydrogen 2.914 N/A ILE 120.A N LYS 117.A O no hydrogen 2.937 N/A ALA 121.A N LEU 135.A O no hydrogen 3.107 N/A HIS 122.A N GLY 115.A O no hydrogen 2.800 N/A HIS 122.A ND1 ASP 100.A OD1 no hydrogen 2.645 N/A ILE 123.A N LEU 133.A O no hydrogen 2.828 N/A TYR 124.A N VAL 113.A O no hydrogen 2.872 N/A TYR 124.A OH GLU 99.A OE1 no hydrogen 2.945 N/A TYR 124.A OH ASP 100.A OD2 no hydrogen 2.526 N/A TYR 124.A OH HIS 122.A ND1 no hydrogen 3.370 N/A ASP 125.A N ASN 130.A O no hydrogen 2.931 N/A ILE 126.A N ASP 111.A O no hydrogen 3.118 N/A THR 128.A N ASP 125.A OD2 no hydrogen 3.007 N/A THR 128.A OG1 ASP 125.A OD2 no hydrogen 3.243 N/A GLY 129.A N ASP 125.A O no hydrogen 2.777 N/A ASN 130.A N THR 128.A OG1 no hydrogen 3.037 N/A LEU 132.A N ILE 123.A O no hydrogen 2.719 N/A LEU 133.A N ILE 123.A O no hydrogen 3.290 N/A LEU 135.A N ALA 121.A O no hydrogen 2.827 N/A ASP 139.A N.A ASN 137.A OD1 no hydrogen 2.947 N/A ASP 139.A N.B ASN 137.A OD1 no hydrogen 2.938 N/A LEU 140.A N ASN 137.A O no hydrogen 3.033 N/A ASN 142.A N ASP 161.A OD2 no hydrogen 2.930 N/A ASN 142.A ND2 ASP 161.A O no hydrogen 2.915 N/A ASN 142.A ND2 PHE 176.A O no hydrogen 3.053 N/A ASN 143.A N ASP 161.A OD2 no hydrogen 2.877 N/A ASN 143.A ND2 ASP 119.A OD2 no hydrogen 2.469 N/A TYR 144.A N ASP 161.A OD1 no hydrogen 2.831 N/A LYS 145.A N MET 181.A O no hydrogen 2.966 N/A ARG 146.A N ASN 182.A O no hydrogen 2.955 N/A ASN 147.A N TYR 144.A O no hydrogen 3.402 N/A ASN 147.A ND2 GLY 118.A O no hydrogen 3.029 N/A ASN 147.A ND2 ASN 160.A OD1 no hydrogen 2.881 N/A CYS 148.A N SER 184.A OG no hydrogen 3.076 N/A CYS 148.A SG ARG 146.A O no hydrogen 3.624 N/A ALA 149.A N THR 116.A OG1 no hydrogen 2.783 N/A THR 150.A N LEU 159.A O no hydrogen 3.031 N/A THR 150.A OG1 GLU 104.A OE1 no hydrogen 2.745 N/A THR 150.A OG1 PHE 151.A O no hydrogen 3.375 N/A ASN 152.A N LEU 157.A O no hydrogen 2.926 N/A ASN 152.A ND2 THR 154.A OG1 no hydrogen 3.005 N/A THR 154.A OG1 ASP 156.A OD2 no hydrogen 2.827 N/A ASP 155.A N ASN 152.A O no hydrogen 2.996 N/A ASP 156.A N THR 154.A OG1 no hydrogen 3.377 N/A LEU 157.A N ASN 152.A OD1 no hydrogen 2.864 N/A VAL 158.A N TRP 165.A O no hydrogen 2.993 N/A LEU 159.A N THR 150.A O no hydrogen 2.937 N/A ASN 160.A N VAL 163.A O no hydrogen 2.903 N/A ASN 160.A ND2 ASP 119.A O no hydrogen 2.853 N/A ASP 161.A N ASN 147.A OD1 no hydrogen 2.759 N/A VAL 163.A N ASN 160.A O no hydrogen 2.850 N/A LEU 164.A N HIS 174.A O no hydrogen 2.768 N/A TRP 165.A N VAL 158.A O no hydrogen 2.806 N/A ASP 166.A N GLN 171.A O no hydrogen 2.924 N/A VAL 167.A N ASP 156.A O no hydrogen 2.939 N/A ARG 168.A NE ASP 166.A OD1 no hydrogen 3.176 N/A ARG 168.A NH2 ASP 166.A OD1 no hydrogen 2.430 N/A SER 169.A N ASP 166.A OD2 no hydrogen 3.012 N/A SER 169.A OG ASP 166.A O no hydrogen 3.552 N/A SER 169.A OG ASP 166.A OD2 no hydrogen 2.812 N/A GLN 171.A N ASP 166.A O no hydrogen 3.392 N/A ILE 173.A N LEU 164.A O no hydrogen 2.774 N/A HIS 174.A N LEU 164.A O no hydrogen 3.380 N/A PHE 176.A N GLY 162.A O no hydrogen 2.945 N/A LYS 178.A NZ ASN 142.A O no hydrogen 2.808 N/A ASN 180.A ND2 ILE 183.A O no hydrogen 3.044 N/A ASN 182.A N ASN 180.A OD1 no hydrogen 2.944 N/A ASN 182.A ND2 GLN 217.A OE1 no hydrogen 2.854 N/A ILE 183.A N ASN 180.A OD1 no hydrogen 2.906 N/A SER 184.A OG ASN 147.A OD1 no hydrogen 3.103 N/A SER 184.A OG CYS 148.A O no hydrogen 3.524 N/A VAL 186.A N ILE 195.A O no hydrogen 2.907 N/A HIS 188.A N GLU 193.A O no hydrogen 3.081 N/A HIS 188.A NE2 ALA 248.A O no hydrogen 2.763 N/A ASN 190.A N HIS 188.A ND1 no hydrogen 2.889 N/A ASN 190.A ND2 GLU 193.A OE2 no hydrogen 3.395 N/A GLY 191.A N HIS 188.A O no hydrogen 3.076 N/A LEU 192.A N ASN 190.A OD1 no hydrogen 2.796 N/A VAL 194.A N.A TRP 201.A O no hydrogen 2.918 N/A VAL 194.A N.B TRP 201.A O no hydrogen 2.885 N/A ILE 195.A N VAL 186.A O no hydrogen 2.833 N/A ILE 196.A N GLU 199.A O no hydrogen 2.838 N/A ASN 197.A ND2 ASP 216.A OD1 no hydrogen 2.999 N/A THR 198.A OG1 GLU 199.A OE1 no hydrogen 3.387 N/A THR 198.A OG1 GLU 199.A OE2 no hydrogen 2.734 N/A GLU 199.A N ILE 196.A O no hydrogen 2.978 N/A ILE 200.A N HIS 210.A O no hydrogen 2.953 N/A TRP 201.A N VAL 194.A O.A no hydrogen 2.876 N/A TRP 201.A N VAL 194.A O.B no hydrogen 2.927 N/A ASP 202.A N HIS 207.A O no hydrogen 2.846 N/A LEU 203.A N LEU 192.A O no hydrogen 2.955 N/A ARG 204.A N ASP 202.A OD1 no hydrogen 2.842 N/A THR 205.A N ASP 202.A OD1 no hydrogen 2.869 N/A PHE 206.A N ASP 202.A O no hydrogen 2.876 N/A HIS 207.A N THR 205.A OG1 no hydrogen 3.310 N/A LEU 209.A N ILE 200.A O no hydrogen 2.807 N/A HIS 210.A N ILE 200.A O no hydrogen 3.350 N/A VAL 212.A N THR 198.A O no hydrogen 2.784 N/A LEU 215.A N VAL 212.A O no hydrogen 2.990 N/A ASP 216.A N PRO 213.A O no hydrogen 3.157 N/A GLN 217.A N ASN 197.A OD1 no hydrogen 2.691 N/A GLN 217.A NE2 ASN 180.A OD1 no hydrogen 3.115 N/A GLN 217.A NE2 ASP 216.A OD1 no hydrogen 2.987 N/A CYS 218.A N LEU 215.A O no hydrogen 3.017 N/A CYS 218.A SG ALA 214.A O no hydrogen 3.570 N/A CYS 218.A SG ASP 216.A O no hydrogen 3.697 N/A ARG 219.A N ALA 232.A O no hydrogen 3.054 N/A ARG 219.A NH1 TYR 102.A OH no hydrogen 2.976 N/A VAL 221.A N TYR 230.A O no hydrogen 2.978 N/A ASN 223.A N VAL 228.A O no hydrogen 2.930 N/A ASN 223.A ND2 THR 227.A OG1 no hydrogen 2.943 N/A HIS 224.A N ASP 272.A OD2 no hydrogen 2.743 N/A HIS 224.A ND1 ASP 272.A OD2 no hydrogen 2.853 N/A THR 225.A OG1 THR 227.A OG1 no hydrogen 3.210 N/A GLY 226.A N ASN 223.A O no hydrogen 3.031 N/A THR 227.A N ASN 223.A OD1 no hydrogen 2.858 N/A THR 227.A OG1 THR 225.A OG1 no hydrogen 3.210 N/A VAL 228.A N ASN 223.A OD1 no hydrogen 3.061 N/A MET 229.A N PHE 246.A O no hydrogen 2.920 N/A TYR 230.A N VAL 221.A O no hydrogen 2.798 N/A GLY 231.A N ARG 244.A O no hydrogen 2.863 N/A ALA 232.A N ARG 219.A O no hydrogen 3.108 N/A LEU 234.A N GLN 217.A O no hydrogen 2.794 N/A GLN 235.A N PRO 238.A O no hydrogen 2.893 N/A SER 237.A OG PHE 239.A O no hydrogen 2.691 N/A PHE 239.A N ILE 263.A O no hydrogen 3.207 N/A GLY 240.A N MET 233.A O no hydrogen 3.286 N/A SER 241.A OG ASP 258.A OD1 no hydrogen 3.469 N/A PHE 243.A N ILE 257.A O no hydrogen 3.025 N/A ARG 244.A N GLY 231.A O no hydrogen 2.868 N/A THR 245.A N ALA 255.A O no hydrogen 2.905 N/A THR 245.A OG1 ALA 255.A O no hydrogen 3.567 N/A PHE 246.A N MET 229.A O no hydrogen 2.714 N/A ASN 247.A N LYS 252.A O no hydrogen 2.870 N/A ALA 248.A N THR 227.A O no hydrogen 2.891 N/A THR 249.A N ASN 247.A OD1 no hydrogen 2.742 N/A THR 249.A OG1 ASN 247.A OD1 no hydrogen 2.520 N/A ASP 250.A N ASN 247.A OD1 no hydrogen 3.247 N/A TYR 251.A N ASN 247.A O no hydrogen 2.782 N/A TYR 251.A OH GLU 193.A OE2 no hydrogen 2.635 N/A LYS 252.A N ASP 250.A OD1 no hydrogen 2.950 N/A ILE 254.A N THR 245.A O no hydrogen 2.777 N/A ILE 257.A N PHE 243.A O no hydrogen 2.838 N/A VAL 259.A N SER 241.A O no hydrogen 3.010 N/A LYS 260.A N ASP 258.A OD1 no hydrogen 3.168 N/A ARG 261.A NE GLU 279.A OE1 no hydrogen 2.713 N/A ARG 261.A NH2 GLU 279.A OE1 no hydrogen 2.691 N/A ILE 263.A N GLY 240.A O no hydrogen 2.888 N/A PHE 264.A N ILE 278.A O no hydrogen 2.881 N/A LEU 266.A N ASP 265.A OD1 no hydrogen 3.035 N/A CYS 267.A N ALA 276.A O no hydrogen 2.982 N/A THR 268.A OG1 ASP 272.A OD1 no hydrogen 2.686 N/A ASP 269.A N TYR 274.A O no hydrogen 3.435 N/A THR 270.A OG1 GLU 26.A OE2 no hydrogen 2.621 N/A ASP 272.A N ASP 269.A O no hydrogen 2.819 N/A CYS 273.A SG LYS 271.A O no hydrogen 3.860 N/A TYR 274.A N ASP 269.A OD1 no hydrogen 2.850 N/A LEU 275.A N TYR 290.A O no hydrogen 2.895 N/A ALA 276.A N CYS 267.A O no hydrogen 2.852 N/A VAL 277.A N ARG 288.A O no hydrogen 2.942 N/A ILE 278.A N ASP 265.A O no hydrogen 2.985 N/A GLU 279.A N VAL 286.A O no hydrogen 2.920 N/A ASN 280.A N ASN 262.A O no hydrogen 2.872 N/A GLN 281.A N ASP 284.A O no hydrogen 2.841 N/A GLY 282.A N ASN 280.A OD1 no hydrogen 2.901 N/A ASP 284.A N ASN 280.A OD1 no hydrogen 3.040 N/A THR 285.A N SER 15.A O no hydrogen 2.892 N/A THR 285.A OG1 SER 15.A O no hydrogen 3.370 N/A THR 285.A OG1 PHE 17.A O no hydrogen 2.678 N/A VAL 286.A N GLU 279.A O no hydrogen 2.956 N/A CYS 287.A N PHE 7.A O no hydrogen 2.952 N/A ARG 288.A N VAL 277.A O no hydrogen 2.828 N/A ARG 288.A NH1 GLN 281.A OE1 no hydrogen 2.882 N/A ARG 288.A NH2 GLU 279.A OE1 no hydrogen 2.916 N/A ARG 288.A NH2 GLN 281.A OE1 no hydrogen 2.888 N/A LEU 289.A N SER 5.A O no hydrogen 2.869 N/A TYR 290.A N LEU 275.A O no hydrogen 2.765 N/A TYR 290.A OH GLU 279.A OE2 no hydrogen 2.655 N/A GLU 291.A N ARG 2.A O no hydrogen 2.795 N/A VAL 292.A N CYS 273.A O no hydrogen 2.951 N/A